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  • MPI Ethno. Forsch.  (195)
  • HeBIS
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (195)
  • Oncology  (195)
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  • MPI Ethno. Forsch.  (195)
  • HeBIS
Material
Language
Years
Author, Corporation
Publisher
Keywords
  • 1
    Online Resource
    Online Resource
    Cervical Cancer : Recent Advances and New Perspectives (2024)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781837693375 , 9781837693399 , 9781837693382
    Language: Undetermined
    Pages: 1 Online-Ressource (86 p.)
    Keywords: Oncology ; Tumor Biology ; Treatment ; Indications ; Limits ; Fertility Sparing Management ; SLN ; Neoadjuvant Treatment ; Radical Surgery ; Targeted Therapy ; Endoscopic Surgery ; Robotic Surgery ; HPV
    Abstract: Cervical Cancer - Recent Advances and New Perspectives is a review of interesting and clinically important advances in the tumor biology and treatment of cervical cancer. The book covers major aspects of scientific progress in the treatment of cervical cancer, focusing on new knowledge due to advances in molecular techniques, understanding of tumor biology, and innovative new treatment options. This book brings together an interesting collection of innovations in the treatment of cervical cancer and opinions from specialists in this field from around the world
    Note: English
    URL: kostenfrei
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  • 2
    Online Resource
    Online Resource
    Molecular Biology and Treatment Strategies for Gliomas (2024)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781837698493 , 9781837698516 , 9781837698509
    Language: Undetermined
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Oncology ; MicroRNAs ; Angiogenesis ; Cytokine Gene Expression ; Checkpoint Inhibitors ; Antigenic Expression ; Immune Evasion ; DNA Vaccines ; Dendritic Cells ; Surgery ; Radiation Therapy ; Immune Modulators ; Gene Therapy
    Abstract: A dramatic increase in knowledge regarding the molecular biology of gliomas has been established over the past few years, and this has led to the development of novel therapeutic strategies for these patients. This book describes some improvements in the surgical management of gliomas, including segmentation of brain MRI images using 4D MRI volumes to help with the diagnosis and monitoring of patients. Another novel topic reviewed involves the applications of photosensitizers and their efficacy in the generation of anti-tumor responses in photodynamic therapy. A review of the application of nanoparticles and their ability to deliver drugs to the tumor site with a reduction in systemic toxicity is another developing therapy discussed. The book also describes novel approaches involving the development of the use of microRNAs, which are non-coding RNAs that can be used as tumor suppressors that potentially can be developed to control the growth of gliomas. The book examines a large number of molecular interactions of signals in gliomas, which should lead to biomarkers of potential importance that could be manipulated in the development of clinical trials. Molecular networks need to be better understood for the development of therapeutic strategies. Finally, the book reviews immunotherapeutic strategies potentially useful in treating brain tumors that involve either poxviruses engineered to secrete IL-15- or IL-2-secreting fibroblasts transfected with tumor DNA. The stimulation of the immune system to selectively attack malignant cells should lead to the prolongation of survival of brain tumor patients without a decline in cognitive functions or other side effects. It is hoped that this new information will lead to improved and efficacious treatment strategies for these challenging tumors
    Note: English
    URL: kostenfrei
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  • 3
    Online Resource
    Online Resource
    Supportive and Palliative Care and Quality of Life in Oncology (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803561868 , 9781803561851 , 9781803561875
    Language: Undetermined
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Oncology
    Abstract: This book examines supportive and palliative care and quality of life in cancer patients. Chapters address such topics as anxiety, depression, and delirium in terminally ill cancer patients, ethics in palliative care, palliative care medications, assisted suicide and euthanasia, and much more
    Note: English
    URL: kostenfrei
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  • 4
    Online Resource
    Online Resource
    Recent Updates on Multiple Myeloma (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803560939 , 9781803560922 , 9781803560946
    Language: Undetermined
    Pages: 1 Online-Ressource (176 p.)
    Keywords: Oncology
    Abstract: This book provides a comprehensive overview of multiple myeloma. It is organized into three sections with chapters addressing topics such as diagnosis, risk stratification, and management of multiple myeloma; treatment of multiple myeloma at diagnosis and at relapse; management of disease complications; and stem cell therapies, including autologous and allogeneic hematopoietic stem cell transplantation with a focus on autologous grafting using non-cryopreserved stem cells and performance of stem cell transplantation in outpatient settings
    Note: English
    URL: kostenfrei
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  • 5
    Online Resource
    Online Resource
    Thyroid Cancer : The Road From Genes to Successful Treatment (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803562858 , 9781803562841 , 9781803562865
    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Oncology
    Abstract: Thyroid cancer is the most common endocrine cancer, although it is relatively rare compared to other cancers. Standard treatment involves thyroidectomy and radioiodine administration followed by life-long thyroxine administration. However, until recently, there was no medical treatment for advanced thyroid cancer. Advances in the genetics of thyroid cancer and in the treatment of other forms of cancer with tyrosine kinase inhibitors have revolutionized the treatment of advanced thyroid cancer. This book provides a comprehensive overview of thyroid cancer. It is organized into two sections on genetics and treatment. Chapters address such topics as the genetic susceptibility to differentiated thyroid cancer, the molecular basis of radioiodine treatment in thyroid cancer, recent developments in the medical treatment of advanced thyroid cancer, systemic therapy in thyroid cancer, and much more
    Note: English
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  • 6
    Online Resource
    Online Resource
    Glioblastoma : Current Evidence (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803561295 , 9781803561288 , 9781803561301
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Oncology
    Abstract: Glioblastoma (GBM) is a common and aggressive brain cancer with features of necrosis and endothelial proliferation in the histopathologic examination. Its presentation and management depend on tumor location, size, grade, and underlying histopathological characteristics. GBM tumors have clinical features of increased intracranial pressure, focal neurological deficits, or seizures (generalized or partial) with rapid progression. This book discusses GBM and its diagnosis, treatment, and management
    Note: English
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  • 7
    Online Resource
    Online Resource
    Leukemia : From Biology to Clinic (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803569062 , 9781803569055 , 9781803569079
    Language: Undetermined
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Oncology
    Abstract: Medical professionals and researchers in the field of leukemias are faced with the need to continuously update their knowledge in a wide range of areas, ranging from fundamental molecular processes and mechanisms to a thorough understanding of clinical features and modern approaches to achieve maximum therapeutic results. This book does not have the ambition to present comprehensively the problems of leukemias, but it is an attempt to acquaint the audience of specialists involved in clinical management and experimental research with some modern advances and concepts in the three main directions: biology, clinical presentation and treatment. The biological aspects of the origin, development and therapy resistance of leukemias are within the scope of the first section. Comprehensive and concise information on the clinical assessment and treatment of leukemia patients is provided, as well as on some specific interdisciplinary clinical scenarios such as leukemic retinopathy, in the second section. Finally, challenges, current standards and recent advances in the therapy of acute leukemias comprise the third section of the book
    Note: English
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  • 8
    Online Resource
    Online Resource
    Clinical Diagnosis and Management of Squamous Cell Carcinoma (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803555416 , 9781803555409 , 9781803555423
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Oncology
    Abstract: Squamous cell carcinoma remains a significant cause of morbidity and mortality. It is a heterogeneous disease with complex molecular abnormalities. Head and neck squamous cell carcinomas (SCC) represent the most frequent human solid tumors and are a major cause of cancer mortality. Highly heterogeneous tumors arise from closely interconnected epithelial cell populations whose intrinsic self-renewal potential is inversely related to the stratified differentiation program. Cancer prevention strategies are theoretically appealing although often difficult to implement, owing to the multifactorial pathogenesis of most cancers. This book focuses on significant variations of squamous cell carcinoma, including squamous cell carcinoma of the vagina, bladder, head and neck
    Note: English
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  • 9
    Online Resource
    Online Resource
    Liver Cancer : Genesis, Progression and Metastasis (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803564142 , 9781803564135 , 9781803564159
    Language: Undetermined
    Pages: 1 Online-Ressource (146 p.)
    Keywords: Oncology
    Abstract: Hepatocellular carcinoma (HCC) is a common tumor type arising from several distinct etiologies. It is usually diagnosed late and is difficult to treat. This volume presents an overview of selected aspects of HCC pathogenesis, and research aimed at developing diagnostic biomarkers. It points to a number of putative therapeutic targets, including signal transduction pathways, metabolic and epigenetic alterations in tumor cells, the tumor microenvironment, the gut microbiome, and functions of immune effector cells. Given the multi-step nature of most cancers, including HCC, future drug development will most likely require combination therapies that will simultaneously target multiple steps in hepatocarcinogenesis
    Note: English
    URL: kostenfrei
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  • 10
    Online Resource
    Online Resource
    Melanoma : Standard of Care, Challenges, and Updates in Clinical Research (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803563992 , 9781803563985 , 9781803564005
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Oncology
    Abstract: Melanoma is an aggressive type of cancer for which treatment has dramatically evolved during the last 15 years, improving response and survival figures. This book, written by a diverse panel of experts, presents a description of the most relevant aspects of the epidemiology, diagnosis, local treatment, prognostic biomarkers and treatment for advanced disease, including the most recent research on novel molecules that are either approved or are undergoing clinical development. It includes insights on such challenging topics as when immunotherapy should be started in BRAF mutant patients, or which is the most appropriate treatment algorithm in those cases, as well as how to handle difficult and poor-prognosis melanoma cases, such as patients with brain metastases or patients with the uveal disease
    Note: English
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  • 11
    Online Resource
    Online Resource
    Central Nervous System Tumors : Primary and Secondary (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803567532 , 9781803567525 , 9781803567549
    Language: Undetermined
    Pages: 1 Online-Ressource (264 p.)
    Keywords: Oncology
    Abstract: Central nervous system (CNS) tumors are a heterogeneous group consisting of more than 100 tumor types originating from the brain, cerebellum, brain stem, spinal cord, and meninges. Despite the positive developments of recent years, especially in the treatment of high-grade brain tumors, treatment outcomes have not yet reached an acceptable level. However, due to advances in clinical and experimental studies, the genetic and molecular structures of many high-grade CNS tumors are now better understood. The World Health Organization’s 2021 Classification of CNS Tumors has aided the understanding of the genetic, molecular and immunological structures of these tumors as well as their interactions with their microenvironment. Targeted therapies and vaccines developed with immunotherapy protocols are promising developments. This book explores the natural history of CNS tumors and discusses relevant treatment protocols
    Note: English
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  • 12
    Online Resource
    Online Resource
    Cancer Metastasis : Molecular Mechanism and Clinical Therapy (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803561622 , 9781803561615 , 9781803561639
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Oncology
    Abstract: Cancer mortality and morbidity are primarily brought on by metastasis. The ability of neoplastic cells to spread and colonize distant tissues is their most dangerous trait. Most malignancies are curable when they are detected early and have not spread outside of the original tissue. However, cancer is frequently incurable when tumor cells have created colonies elsewhere. Thus, the book content This book provides comprehensive information on cancer metastasis, along with references to specific cancer cases. The topics discussed include invasion by perturbation of cell-cell and cell-matrix adhesion, matrix degradation, motility, intravasation, extravasation, metastatic colonization, metastasis and angiogenesis. Molecular mechanisms, the metastatic process, and palliative bone metastasis therapy are also considered
    Note: English
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  • 13
    Online Resource
    Online Resource
    Pancreatic Cancer : Updates in Pathogenesis, Diagnosis and Therapies (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803559223 , 9781803559216 , 9781803559230
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Oncology ; pancreas ; obesity ; epidemiology ; risk factors ; screening ; pathology
    Abstract: Pancreatic Cancer - Updates in Pathogenesis, Diagnosis and Therapies presents the most recent knowledge on pancreatic cancer, which is a deadly, challenging and catastrophic tumor with a high mortality rate. It is the seventh leading cause of cancer-related mortality worldwide. Pancreatic cancer can be diagnosed clinically, by laboratory measures, by imaging, and by pathological detection. Understanding tumor pathogenesis as well as tumor risk factors is necessary for successful treatment, as is early detection and multidisciplinary treatment. This book provides a comprehensive overview of pancreatic cancer in four sections. Chapters address such topics as prevention, screening, and detection; pathogenesis and risk factors; and pathology and management
    Note: English
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  • 14
    Online Resource
    Online Resource
    Tumor Microenvironment : New Insights (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839693809 , 9781839693793 , 9781839693816
    Language: Undetermined
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Oncology ; cancer ; metabolism ; lung cancer ; nutrients ; minimally invasive surgery ; liquid biopsy
    Abstract: This book offers outstanding approaches to understanding the role of the tumor microenvironment (TME) in cancer development and metastasis. The TME, with its multifaced role, is fundamental in the control and exacerbation of almost all cancer types. The outcome of many solid tumors is dependent on the modulation of the TME. Local tumor immunity, which is crucial in the control of cancer promotion, is one of the leading compounds of the TME. This book presents new insights and provides detailed and updated descriptions of the role of the TME in the control and the development of almost all cancer types. This book is an authentic source of knowledge, useful for researchers, medical doctors, students, and all individuals interested in understanding the mechanisms of cancer control and development
    Note: English
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  • 15
    Online Resource
    Online Resource
    Renal Cell Carcinoma : Recent Advances, New Perspectives and Applications (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839694707 , 9781839694691 , 9781839694714
    Language: Undetermined
    Pages: 1 Online-Ressource (118 p.)
    Keywords: Oncology ; immunotherapy ; genetics ; ultrasound ; mri ; targeted therapy ; epigenetic
    Abstract: In the past decade, we have witnessed innovation in surgical treatment for renal cell carcinoma (RCC), including robotic platforms with integration of imaging approaches, and advances in targeted therapy, immunotherapy, and combination therapy to treat patients with advanced RCC. This book presents updated information on the epidemiology, genetics, diagnosis, screening, and advances in the treatment and management of RCC. It is a useful resource for any clinician involved in the management of patients with RCC, as well as other physicians, researchers, and patients
    Note: English
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  • 16
    Online Resource
    Online Resource
    Neurofibromatosis : Diagnosis and Treatments (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781837695799 , 9781837695812 , 9781837695805
    Language: Undetermined
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Oncology ; Neurofibromatosis 1 ; Schwannomatosis ; Risk Factors ; Neurofibromatosis 2 ; Epidemiology ; Diagnosis ; Cancer Therapies ; Physiological Dysfunction ; Chemotherapy ; Surgery ; Monitoring ; Gene Immunotherapy
    Abstract: This book describes and discusses numerous new concepts and procedures for the diagnosis and management of all types of neurofibromatosis (NF). It includes five chapters that address numerous topics in the field, including the management of toxicities associated with NF treatment modalities. It provides useful information and data for both researchers and practitioners to develop new approaches for the management of NF
    Note: English
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  • 17
    Online Resource
    Online Resource
    Brain Tumors (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839698040 , 9781839698033 , 9781839698057
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Oncology
    Abstract: Brain tumors comprise a spectrum of histological patterns. Their presentation and management depend on their location, size, and grade of lesions. This book is a collection of high-quality research work from global experts on brain tumors, including meningiomas, and their treatment
    Note: English
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  • 18
    Online Resource
    Online Resource
    Hepatocellular Carcinoma : Challenges and Opportunities of a Multidisciplinary Approach (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839691119 , 9781839691102 , 9781839691126
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Oncology
    Abstract: Hepatocellular carcinoma (HCC) represents one of the most significant global health issues, given its high prevalence and the challenging nature and physiology of the liver and hepatic surgery, in its many forms. This means that the most appropriate management for HCC should incorporate a multidisciplinary approach, combining the expertise from several different specialties. This book showcases the various steps in the development, diagnosis, staging, and management of HCC and provides views and thoughts from true experts in the field. As such, it is a useful resource for any physician or surgeon, whether training or practicing, who is interested in caring for patients with HCC
    Note: English
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  • 19
    Online Resource
    Online Resource
    Mesothelioma : Diagnostics, Treatment and Basic Research (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803553498 , 9781803553481 , 9781803553504
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Oncology
    Abstract: This book is devoted to the state of the art, pitfalls and perspectives in the diagnosis and treatment of mesothelioma – a peculiar malignant tumour arising from mesothelial cells that line the pleura, the pericardium and the peritoneum. Mesothelioma is known for its strong association with asbestos exposure, difficult surgical treatment and dismal prognosis. However, recent years have yielded significant discoveries on, for example, germline mutations in BAP1 gene coding BRCA1-associated protein 1, the pathogenetic role of inflammation, and innovative treatment approaches such as immune checkpoint inhibitors. The volume is intended to summarise classic views and innovations in the pathogenetic concepts, diagnostics, treatment and scientific studies of mesothelioma, resulting in a comprehensive reference work as well as a source of ideas for relevant clinical and basic research
    Note: English
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  • 20
    Online Resource
    Online Resource
    Recent Understanding of Colorectal Cancer Treatment (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803561325 , 9781803561318 , 9781803561332
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Oncology
    Abstract: From surgery to chemotherapy and radiotherapy, attempts to conquer colorectal cancer have been ongoing for a century. Due to these efforts, the mortality rate of colorectal cancer has decreased by about 3% per year for the past 10 years. Progress in reducing mortality from colorectal cancer can be accelerated by improving screening and the use of standard care in all populations. In recent years, advanced knowledge and technologies for better efficiency in targeting colorectal cancer have been developed to improve conventional therapeutics or to propose new therapies as standard regimens. This book discusses diagnostics as well as surgical techniques using robotics, immunotherapy, and radiology-based therapy for colorectal cancer. The section on diagnostics provides information on proteomics, organoid culture techniques, and various candidate markers. The section on treatment discusses robotic surgical techniques for rectal cancer care and multidisciplinary approaches for colorectal cancer treatment. The book also examines the latest in supportive care from a nutritional and metabolic point of view
    Note: English
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  • 21
    Online Resource
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    Cancer Bioinformatics (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839691089 , 9781839691072 , 9781839691096
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Series Statement: Biomedical Engineering 12
    Keywords: Oncology
    Abstract: This book discusses the application of bioinformatics in cancer disease management. It covers general aspects of cancer as a disease but also as a success story in the translation of omics data in clinical settings. It provides an overview of the specific applications of bioinformatics tools in cancer epidemiology, prevention, and screening and in the identification of novel genetic and molecular biomarkers involved in cancer development. This is accomplished through the inclusion of numerous examples of the use of bioinformatics in precision oncology
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  • 22
    Online Resource
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    Central Nervous System Tumors (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839693076 , 9781839693069 , 9781839693083
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Oncology
    Abstract: Though the treatment of central nervous system (CNS) tumors has been challenging, new advances have helped us better understand the molecular and genetic makeup of many tumor types, and new chemotherapies and immunotherapies have extended survival in patients with aggressive primary CNS tumors. This book discusses pediatric and adult tumors of the CNS, the classification schemes used to categorize them, advances in surgical techniques, and several important genetic alterations found in these tumors. We hope this book contributes to the reader's understanding of these tumors and provides the most up-to-date and cutting-edge discoveries in this exciting field
    Note: English
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  • 23
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    Oral Cancer : Current Concepts and Future Perspectives (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789846713 , 9781789846706 , 9781789856576
    Language: Undetermined
    Pages: 1 Online-Ressource (136 p.)
    Keywords: Oncology
    Abstract: Oral cancer is a common disease with a high incidence of morbidity and mortality. Despite technological advancements in diagnosis and treatment, the five-year survival rate is low. Researchers worldwide are attempting to identify new and novel methods for early diagnosis and better treatment of oral cancer to improve survival rate and quality of life post recovery. This book examines current concepts in oral cancer and emphasizes future perspectives for diagnosis and treatment of disease for better clinical outcomes and patient care
    Note: English
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  • 24
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    Lymphoma (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839681127 , 9781839681110 , 9781839681172
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Oncology
    Abstract: Lymphoma is a group of malignant diseases caused by the clonal proliferation of lymphocytes. Current treatment options include chemotherapy, radiotherapy, and bone marrow/stem cell transplantation. Development of new treatment options for cancer medications include small molecules and monoclonal antibodies for immunotherapy. In addition, the discovery of new phytochemical agents used in complementary and alternative medicine adds perspective to the treatment of lymphoma. This book highlights recent developments in the treatment of lymphoma. Chapters discuss different types of lymphomas, such as follicular lymphoma, gastrointestinal lymphoma, splenic B-cell lymphoma, and others, as well as the available treatment options for each
    Note: English
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  • 25
    Online Resource
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    Tumor Angiogenesis and Modulators (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803558356 , 9781803558349 , 9781803558363
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Oncology
    Abstract: Tumor angiogenesis is critical for tumor growth and progression. It is a multistep and complicated process, and the mechanism underlying tumor angiogenesis is not fully elucidated. Recent advances in tumor angiogenesis research have led to improved diagnosis, drug treatment, and clinical management of cancer. However, novel strategies for cancer treatment are urgently needed, especially biomarker discovery for diagnosis, prognosis, and targeted therapy. This book presents the most recent advances in tumor angiogenesis
    Note: English
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  • 26
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    Advances in Soft Tissue Tumors (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803557243 , 9781803557236 , 9781803557250
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Oncology
    Abstract: This book aims to foster collaboration between world-class bench scientists and clinicians in the fields of oncology, surgery, and pathology as they come together to highlight the complexity and diversity of soft tissue tumors as well as recent advances in their diagnosis and clinical management
    Note: English
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  • 27
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    Our Journey Beyond Sunset Boulevard : Evidence-based Analysis of Tumor-Targeted Gene- and Immuno-Therapies Shine a Critical Spotlight on 'True' Long-Term Cancer-Free Survival (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839694165 , 9781839694158 , 9781839694172
    Language: English
    Pages: 1 Online-Ressource (56 p.)
    Keywords: Oncology
    Abstract: The revival of DeltaRex-G (formerly Rexin-G)'”the first proactive tumor-hunting/tumor-killing biomedicine of this kind in history'”returned active tumor surveillance and a precision-guided 'silver bullet' (dnG1 killer gene) to the cancer clinic with 'Expanded Access' in 2019. Empowered by US Right-to-Try legislation, while honoring ethical principles of 'informed consent,' this unique graphic/picturesque presentation of clinical and translational medicine is intended for postmodern (post-Enlightenment) layman readers, including cancer patients, students, researchers, and future practitioners in the field of precision gene-based medicine. Confronting logical fallacies in popular opinion, the authors present newsworthy, up-to-date clinical research documenting the successful management of refractory metastatic cancers with tumor-targeted gene therapy vectors'”validating 'pathotropic' (disease-seeking) tumor targeting avant la lettre
    Note: English
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  • 28
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    Pheochromocytoma, Paraganglioma and Neuroblastoma (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839689482 , 9781839689475 , 9781839689499
    Language: Undetermined
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Oncology
    Abstract: Pheochromocytoma, paraganglioma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. These neoplasms are associated with significant morbidity and mortality. Some international studies currently underway are researching and evaluating the presence of any similarities and differences between these tumors. Hopefully, future results will reveal several potential novel genes and pathways that might have major roles in the pathogenesis and progression of these neoplasms. This book discusses epidemiology, genetics, and treatment of these malignancies
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  • 29
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    Translational Research in Cancer (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838805357 , 9781838805340 , 9781789848373
    Language: English
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Oncology
    Abstract: Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer
    Note: English
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  • 30
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    Acute Leukemias (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838811693 , 9781838811686 , 9781838811730
    Language: English
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Oncology
    Abstract: Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia
    Note: English
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  • 31
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    Protein Kinases : Promising Targets for Anticancer Drug Research (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838809072 , 9781838809065 , 9781838809089
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Series Statement: Biochemistry 24
    Keywords: Oncology
    Abstract: For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and anticancer activity of protein kinase inhibitors on various cancer types. They also discuss new opportunities, challenges, and future perspectives in the field
    Note: English
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  • 32
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    Multiple Myeloma (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839686214 , 9781839686207 , 9781839686221
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Oncology
    Abstract: This book deals with the diagnosis and treatment of multiple myeloma. Multiple myeloma is a plasma cell disorder, the prognosis of which has dramatically improved in the last years thanks to new immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies, in relapsed/refractory disease and a diagnosis. Chapters cover such topics as prognostic and predictive factors in newly diagnosed multiple myeloma, treatment approaches, antibody therapies, and three-dimensional (3D) models mimicking multiple myeloma bone marrow-microenvironment interactions
    Note: English
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  • 33
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    Colorectal Cancer (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838811037 , 9781838811020 , 9781838811174
    Language: English
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Oncology
    Abstract: Colorectal cancer is the third most common cancer diagnosed in both men and women worldwide. This book examines state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. It emphasizes the importance of a multidisciplinary approach involving multiple specialties, including surgery, gastroenterology, radiology, biology, oncology, radiotherapy, nuclear medicine, and physiotherapy
    Note: English
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  • 34
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    Advances in Precision Medicine Oncology (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839688683 , 9781839688676 , 9781839688690
    Language: Undetermined
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Oncology
    Abstract: Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects
    Note: English
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  • 35
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    Melanoma (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838808792 , 9781838808785 , 9781838808808
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Oncology
    Abstract: Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making it one of the most significant cancers responsible for productive years of life lost. Fortunately, there has been unprecedented progress in the treatment of advanced melanoma, largely through advances in understanding how to manipulate immune responses and target selective genetic mutations in melanoma patients. Clinical benefits to patients with advanced melanoma have been nevertheless limited by the development of innate and acquired drug resistance, and numerous efforts are focusing on the elucidation of these mechanisms. Combination strategies are being actively investigated to overcome drug resistance, by awakening existing anti-tumor mechanisms disabled by a cancer-promoting microenvironment. This book explores the advances and challenges associated with melanoma today, particularly those related to its diagnosis and management. It also proposes new avenues for therapeutic opportunities based on sustained research efforts and ever-growing technological advances. This is a relevant source of knowledge, very useful for researchers, medical doctors, health providers and all individuals interested in learning more about this devastating disease
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  • 36
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    Challenges in Pancreatic Cancer (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839629594 , 9781839629587 , 9781839629600
    Language: Undetermined
    Pages: 1 Online-Ressource (114 p.)
    Keywords: Oncology
    Abstract: Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance
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  • 37
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    Lung Cancer : Modern Multidisciplinary Management (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789855760 , 9781789855753 , 9781789856385
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Oncology
    Abstract: Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts
    Note: English
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  • 38
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    Our Journey Beyond Sunset Boulevard : Evidence-based Analysis of Tumor-Targeted Gene- and Immuno-Therapies Shine a Critical Spotlight on “True” Long-Term Cancer-Free Survival (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839694165 , 9781839694158 , 9781839694172
    Language: Undetermined
    Pages: 1 Online-Ressource (56 p.)
    Keywords: Oncology
    Abstract: The revival of DeltaRex-G (formerly Rexin-G)—the first proactive tumor-hunting/tumor-killing biomedicine of this kind in history—returned active tumor surveillance and a precision-guided “silver bullet” (dnG1 killer gene) to the cancer clinic with “Expanded Access” in 2019. Empowered by US Right-to-Try legislation, while honoring ethical principles of “informed consent,” this unique graphic/picturesque presentation of clinical and translational medicine is intended for postmodern (post-Enlightenment) layman readers, including cancer patients, students, researchers, and future practitioners in the field of precision gene-based medicine. Confronting logical fallacies in popular opinion, the authors present newsworthy, up-to-date clinical research documenting the successful management of refractory metastatic cancers with tumor-targeted gene therapy vectors—validating “pathotropic” (disease-seeking) tumor targeting avant la lettre
    Note: English
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  • 39
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    Cutaneous Melanoma (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789841404 , 9781789841398 , 9781789856521
    Language: English
    Pages: 1 Online-Ressource (100 p.)
    Keywords: Oncology
    Abstract: According to the American Cancer Society, skin cancer is the most common cancer of all cancer types. Although melanoma represents only about 1% of all skin cancers, this tumour is still responsible for most skin cancer deaths and its incidence is steadily on the rise.The first section of this book covers the topic of genetic and epigenetic regulation of the melanoma progression. The second section focuses on special melanoma scenarios: melanoma in pregnancy and subungual melanoma. The third section follows the emerging trend of implementing mathematic models in skin cancer diagnosis. I hope that this book, written by international experts, will be a useful resource for both clinicians and researchers in the field
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  • 40
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    Tumor Progression and Metastasis (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789853506 , 9781789853490 , 9781789851465
    Language: English
    Pages: 1 Online-Ressource (318 p.)
    Series Statement: Physiology 8
    Keywords: Oncology
    Abstract: This book offers significant coverage on different aspects of cancer from risk factors to the mechanisms leading to tumor progression and metastasis. Although tremendous progress has been made in cancer research and treatment, cancer metastasis remains a major unmet clinical need. The life and death of many cancer patients hangs on the degree of metastasis. This book provides new perspectives for diagnosis and cancer therapy. It includes new technologies and a new basis for current cancer therapies. To guarantee the high quality of this book, important topics are included and rigorously discussed in a simple and authentic way. The book addresses important challenges governing tumor progression and metastasis and brings new responses to both diagnosis and therapy. This book is a great source of knowledge and will be useful for researchers, medical doctors, oncologists, graduate and medical students, continued medical educators, health care providers, and all individuals interested in understanding cancer and its challenges
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  • 41
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    Current Cancer Treatment (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789859683 , 9781789859676 , 9781838809980
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Oncology
    Abstract: This book is a collection of in-depth chapters on many aspects of contemporary cancer treatment. Written by experts worldwide, each chapter provides a detailed summary of the state-of-the art knowledge in the area, with extensive references and clear and informative diagrams. The volume is divided into two sections: “Basic Science” and “Clinical Challenges.” The five chapters in the first section cover MicroRNA, the role of angiogenesis in the tumor microenvironment, microbial metabolites in the gastrointestinal microenvironment, the role of dendritic cells in anti-tumor immunity, and challenges of current cancer biomarkers. The two chapters in the second section cover pediatric CNS tumors and the role of sentinel node biopsy in endometrial cancer. The information in this book is designed for cancer clinicians and interested readers to whom this knowledge is important for focusing research and improving patient outcomes
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  • 42
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    Brain and Spinal Tumors : Primary and Secondary (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789841589 , 9781789841572 , 9781839627941
    Language: English
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Oncology
    Abstract: Numerous new concepts and procedures are reviewed and discussed in this book and allude to the transport of drugs to the brain. New radiation concepts are also presented, plus management of toxicities associated with both treatment modalities. It is the goal of this book to provide information and data that will be useful for both researchers and practitioners to develop new approaches for the management of CNS malignancies
    Note: English
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  • 43
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    Neurofibromatosis : Current Trends and Future Directions (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789855302 , 9781789855296 , 9781838805760
    Language: English
    Pages: 1 Online-Ressource (120 p.)
    Keywords: Oncology
    Abstract: Neurofibromatosis, one of the most common genetic disorders, is a group of three conditions—Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis—that share some clinical features, such as the presence of cranial and spinal nerve sheet tumors. However, they differ in type of genetic disorder, age of clinical onset, manifestations, management and prognosis. Due to multisystem involvement, a multidisciplinary treatment approach that includes research is ideal. This book provides a systematic, comprehensive and updated outline of Neurofibromatosis. It is a useful reference for clinicians, researchers and students
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  • 44
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    Gynaecological Malignancies : Updates and Advances (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838803063 , 9781838803056 , 9781838802790
    Language: English
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Oncology
    Abstract: “Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored
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  • 45
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    Mesothelioma (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839681554 , 9781839681547 , 9781839681561
    Language: English
    Pages: 1 Online-Ressource (118 p.)
    Keywords: Oncology
    Abstract: Mesothelioma is an aggressive cancer with very poor survival and lack of treatment options. This book, written by a diverse panel of experts, presents a description of the most relevant topics on epidemiology, diagnosis, biomarkers, and treatment updates, including interesting discussion on molecular mechanisms, prognostic features, and novel therapies that are either approved or under clinical development for this challenging disease. It also discusses and explains genetic biomarkers, as there may be a role for some nuclear regulatory genes and proteins in development of mesothelioma, although targeted therapies so far have had limited impact
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  • 46
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    Squamous Cell Carcinoma : Hallmark and Treatment Modalities (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789843248 , 9781789843231 , 9781789855920
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Oncology
    Abstract: With the support of multinational specialists, each with different background and separate field of expertise in oncology, this book had the occasion to emerge and to offer physicians, researchers and academics efficient, well-organized and updated scientific information related to the characteristics and treatment modalities of squamous cell carcinoma. It provided in-depth information regarding the comprehension of the molecular interaction of signalling pathways and new phenotypes that might result and lead to further cell proliferation and metastases. It also emphasized on the management and individualization of treatment strategies in different types of SCC, applying molecular profiling and approved protocols in order to identify new treatment opportunities. This book also discussed the potential therapeutic modalities that might arise upon understanding and exploring the role of key regulatory proteins that govern the process of cutaneous SCC progression. And Lastly, it underlined the molecular aberrations present in SCC of different organs and the possibility of emerging new therapeutic drugs by targeting these abnormalities. It is really an innovative record that combined novel information from various medical sources and mixed it to become unified in its scientific profit
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  • 47
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    Normal and Malignant B-Cell (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789856019 , 9781789854305 , 9781789856026
    Language: English
    Pages: 1 Online-Ressource (162 p.)
    Keywords: Oncology
    Abstract: Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology
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  • 48
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    Asbestos-related Diseases (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838808334 , 9781838808327 , 9781838808341
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Keywords: Oncology
    Abstract: The issue of asbestos exposure and the resulting health problems is now a global problem. The World Health Organization (WHO) has made recommendations on the eradication of asbestos-related diseases. However, malignant mesothelioma, mainly due to asbestos exposure, is a refractory malignant tumor, and technological innovation in diagnosis and treatment is required. In this context, this book describes the immunological effects of asbestos exposure, blood biomarkers, the pathology of malignant mesothelioma, and the status of immune checkpoint drugs in the treatment of malignant mesothelioma, along with the status of MMP mesothelioma. Concerns about health hazards associated with asbestos exposure may persist for many years to come. We hope this book will help researchers in this area
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  • 49
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    Germ Line Mutations Associated Leukemia (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789840247 , 9781789840230 , 9781789844030
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Keywords: Oncology
    Abstract: In the current practice of modern medicine, the treatment of infectious and nutritional disorders is well established. In contrast, currently genetic disorders/diseases and cancer constitute a substantial load in the clinic. The care of genetic-based diseases and cancer has become a major task in medical practices worldwide and it is unprecedented. It will be rare for any family to be entirely free of genetic disease, therefore genetic diseases impose a huge burden upon individuals, families, and societies. Modern medicine is at the crossroads in the new genomic era with the development of more and more modern technologies. Remarkable advances have been well achieved in defining and classifying these genetic-associated diseases. The identification of the genetic landscape of germ line mutations-associated leukemia caused by either inherited gene mutations or syndromes has led to a deep understanding of leukemogenesis, recognition of clinical diagnosis, and translation into clinical practice in its specific management strategies
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  • 50
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    Prevention, Detection and Management of Oral Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845037 , 9781789845020 , 9781789846041
    Language: English
    Pages: 1 Online-Ressource (114 p.)
    Keywords: Oncology
    Abstract: Up to 70% of oral cancers are preceded by premalignant oral lesions, such as persistent red or white patches in the mouth. Survival rates for oral cancer can be improved through early detection. It is therefore essential that oral health professionals such as dentists, dental hygienists, dental therapists, and oral health therapists understand the importance of conducting a thorough oral screening examination for malignant and potentially malignant lesions as part of their routine clinical assessments, even in younger populations considered at lower risk for oral cancer. Key features of the book include: laser treatment techniques ,human genome sequencing, early detection and multidisciplinary approach ,management strategies and mechanisms of proliferation and energy metabolism in oral cancer
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  • 51
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    Advances in Hematologic Malignancies (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789239423 , 9781789239416 , 9781839626579
    Language: English
    Pages: 1 Online-Ressource (176 p.)
    Keywords: Oncology
    Abstract: The book Advances in Hematologic Malignancies presents new knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic, and genomic changes that have influenced the current outlook toward hematological malignancies. This book provides a unique, practical, and concise guide that is focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. Advances in Hematologic Malignancies is designed and organized as an essential reference source for the hematologist, hematologic oncologist, hematopathologist, and trainee
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  • 52
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    Gene Expression Profiling in Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838801762 , 9781838801755 , 9781789853834
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Oncology
    Abstract: The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer
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  • 53
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    Cancer Immunotherapy and Biological Cancer Treatments (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789848632 , 9781789848625 , 9781789843668
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Oncology
    Abstract: In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy
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  • 54
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    Tyrosine Kinases as Druggable Targets in Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789848090 , 9781789848083 , 9781839622199
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Oncology
    Abstract: Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment
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  • 55
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    Multidisciplinary Approach for Colorectal Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789844009 , 9781789843996 , 9781839680434
    Language: English
    Pages: 1 Online-Ressource (106 p.)
    Keywords: Oncology
    Abstract: A multidisciplinary understanding of the various processes leading to colorectal cancer progression is important for creating promising methods of therapy. Therefore it is necessary to scrutinize the progression of cancer and the therapeutic process through various academic theories. This book examines colorectal cancer - its prevention, pathogenesis, and treatment - through a multidisciplinary lens in an effort to advance understanding of the disease and improve therapeutic efficacy
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  • 56
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    Advances in the Molecular Understanding of Colorectal Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789850604 , 9781789850598 , 9781839620041
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Oncology
    Abstract: An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer
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  • 57
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    Primary Intracranial Tumors (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789854060 , 9781789854053 , 9781839620805
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Oncology
    Abstract: This book covers specific chapters with fundamental and current concepts about the main primary intracranial tumors, aimed at general neurosurgeons, neurologists, oncologists, radiotherapists, and residents. They are everyday situations from the subspecialist routine that can become challenging for professionals outside referenced centers or working alone
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  • 58
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    Cancer Survivorship (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789849073 , 9781789849066 , 9781838817893
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Oncology
    Abstract: This book is a marvelous compendium of eight articles that cover a wide range of topics, including breast cancer: management and survivorship, rectal cancer intersphincteric resection, head and neck cancer diagnosis and radiotherapy, synthetic peptides as antitumor agents, and recent advances in thyroid cancer. It has been a wonderful opportunity to co-edit this special edition. We are greatly appreciative of the work of all the contributors to the book, who brought with them tremendous diversity of perspectives and fields truly reflective of the complexity of the topic and who, through coming together in this project, serve as a nidus of the multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies that have provided the information that has advanced the field so greatly in recent years
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  • 59
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    Bile Duct Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789238761 , 9781789238754 , 9781839622151
    Language: Undetermined
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Oncology
    Abstract: Cholangiocarcinoma is a type of malignant tumor that affects the biliary system. It can arise anywhere in the bile ducts, manifesting itself as obstructive jaundice. It has an annual incidence of 1-2 cases per 100,000 people. One variety of the disease, the Klatskin tumor, occurs in the hepatic hilum and is characterized by poor prognosis. Generally, cholangiocarcinomas are slow-growing tumors with late metastases. Localized tumors are treated surgically, but intervention is discouraged when they are extensive. The disease affects both sexes, but most cases occur in patients aged over 60 years. Primary sclerosing cholangitis, chronic biliary infection, and choledochal cysts are associated with an increased risk of cholangiocarcinoma
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  • 60
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    Recent Developments in Myelodysplastic Syndromes (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789854787 , 9781789854770 , 9781839620409
    Language: Undetermined
    Pages: 1 Online-Ressource (120 p.)
    Keywords: Oncology
    Abstract: This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit
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  • 61
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    Update on Multiple Myeloma (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789852189 , 9781789852172 , 9781839620287
    Language: Undetermined
    Pages: 1 Online-Ressource (234 p.)
    Keywords: Oncology
    Abstract: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries
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  • 62
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    Prostatectomy (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838806859 , 9781838806842 , 9781838806866
    Language: Undetermined
    Pages: 1 Online-Ressource (184 p.)
    Keywords: Oncology
    Abstract: The prostate gland is one of the male organs that have changed over the years. Those changes lead to a disruption of the quality of life and risk of prostate cancer in men over 50 years of age. In the era of prostate-specific antigen it is possible to overcome prostate cancer through early diagnosis. This made it possible to treat the diagnosis of prostate cancer and prevent the development of prostate cancer disease in the patient. In addition, early diagnosis has led to advances in the technological development of the basic surgical technique - prostatectomy. This book contains the efforts of a number of doctors and scientists interested in the prostate gland from different countries around the world. Some of these studies are likely to pose new challenges and trends in the diagnosis of the prostate gland and basic surgical technique
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  • 63
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    Glioma : Contemporary Diagnostic and Therapeutic Approaches (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789849547 , 9781789849530 , 9781838816551
    Language: Undetermined
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Oncology
    Abstract: The past three decades have been marked with huge enthusiasm from scientists and professionals in an effort to find a cure for glioma disease. Methods to confirm the kinds and grades of glioma have taken a path from classical macro- to microscopic pathohystological confirmation of tumors, through morphological-histological, molecular, and genetic diagnosis. Surgically, progress was made possible with the development and use of technological aids, for example neuronavigation, cortical mapping, electrocorticography, neuromonitoring, functional and intraoperative MRI, magnetoencephalography, etc. Great hope was placed on the extension of tumor resection and popular supratotal resection. Significant progress has been made generally in glioma treatment with the use of modern radiotherapy and new chemotherapeutics. What do we want to see for the future? By way of stem cells, a specific medicine will be produced, individualized for the particular patient, and by using a microcapsule it will be implanted into the brain zone affected by the tumor by way of robot surgery and injection needle. This is not at all an unrealistic expectation in the next decade or two
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  • 64
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    Oncogenes and Carcinogenesis (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789851724 , 9781789851717 , 9781839620621
    Language: Undetermined
    Pages: 1 Online-Ressource (106 p.)
    Keywords: Oncology
    Abstract: Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis
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  • 65
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    Peripheral T-cell Lymphomas (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838812263 , 9781838812256 , 9781838812270
    Language: Undetermined
    Pages: 1 Online-Ressource (132 p.)
    Keywords: Oncology
    Abstract: In this book the reader will find a collection of chapters written by different research teams describing different aspects of peripheral T-cell lymphoma pathobiology, classification, and treatment. This work is mainly addressed to researchers already working in this area, but it is also accessible to anyone with a scientific background who desires to have an updated overview of the recent progress in this domain. It will also be valuable to scientists and physicians who have become newly involved in this field. Each chapter is self-contained and can be read independently of the others. This book intends to provide highlights of the current research as well as the current gold standards for diagnosis and treatment of these diseases, showing the recent advances in the personalized approach to T-cell derived lymphomas
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  • 66
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    Gastric Cancer : An Update (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789857467 , 9781789857450 , 9781839620959
    Language: Undetermined
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Oncology
    Abstract: This book, Gastric Cancer - An Update, is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of gastric cancer. The book is comprised of single chapters authored by various researchers and it is edited by experts active in this field of study. All chapters are complete in itself but united under a common research topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on gastric cancer, and opening new possible research paths for further novel developments
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  • 67
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    Current Trends in Cancer Management (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838800062 , 9781838800055 , 9781839622076
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Oncology
    Abstract: The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques
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  • 68
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    Knowledges on Thyroid Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789239843 , 9781789239836 , 9781838818913
    Language: Undetermined
    Pages: 1 Online-Ressource (116 p.)
    Keywords: Oncology
    Abstract: Thyroid cancer is being increasingly diagnosed nowadays. This situation has attracted the attention of scientists and physicians alike and new applications in diagnosis and treatment are being developed and used. There are many cases associated with thyroid cancer and in this book, thyroid cancer is examined in various aspects
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  • 69
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    Cancer Prognosis (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789847758 , 9781789847741 , 9781838817220
    Language: English
    Pages: 1 Online-Ressource (76 p.)
    Keywords: Oncology
    Abstract: Cancer is a DNA disease in which the early stage is represented by the inactivation of suppressor genes and activation of oncogenes, which result in transformed cells that grow out of biological control. Tumor progression is locally favored by mitogenic effects of hormones, or growth factors that stimulate the tumor's growth, or by inducing angiogenesis. The book contains chapters written by experts in the topic, and exhibits current developments in the methodology of cell and molecular biology, which have deeply advanced the understanding of cancer's prevention and prognosis. We hope that it will be helpful for physicians, researchers, and students in life sciences, and will stimulate discussion and research for new therapeutic approaches against cancer
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  • 70
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    Neoplasm (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789237788 , 9781789237771 , 9781838813932
    Language: Undetermined
    Pages: 1 Online-Ressource (254 p.)
    Keywords: Oncology
    Abstract: Neoplasm refers to an abnormal tissue growth that arises as a consequence of rapid cell proliferation and continues to grow abnormally even after terminating the stimuli that had instigated the change. It lacks partial or complete functional coordination with that of the normal tissues. Neoplasms are classified depending on the degree and type of tissues involved. Carcinogenesis is a multistep process where a plethora of endogenous and exogenous factors turns out genetic and epigenetic modifications, which collectively amend some critical cellular pathways controlling the proliferation, apoptosis, and differentiation. The cells having aberrant modifications are transformed into malignant ones of which the clonal expansion results in the development of cancer. This book provides the reader with a comprehensive overview of various cancer types along with their molecular mechanisms of initiation and progression. It also describes the current knowledge about the state-of-the-art measures being employed in cancer diagnosis and therapeutics. Particular attention is paid to make this book equally useful for students, practitioners, and expert scientists
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  • 71
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    Cancer Causing Substances (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789231410 , 9781789231403 , 9781838812959
    Language: Undetermined
    Pages: 1 Online-Ressource (80 p.)
    Keywords: Oncology
    Abstract: Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches
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  • 72
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    Cancer Metastasis (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789846331 , 9781789846324 , 9781838818012
    Language: Undetermined
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Oncology
    Abstract: Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis
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  • 73
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    Hepatocellular Carcinoma : Advances in Diagnosis and Treatment (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789842746 , 9781789842739 , 9781838814151
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Oncology
    Abstract: Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed
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  • 74
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    Myeloid Leukemia (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789231038 , 9781789231021 , 9781838813666
    Language: Undetermined
    Pages: 1 Online-Ressource (190 p.)
    Keywords: Oncology
    Abstract: This book offers a remarkable coverage of myeloid leukemia from diagnosis to treatment. It provides an updated and new vision of this multifaceted disease, regrouping a variety of myeloid disorders. To ensure the high quality of this book, important insights are included and rigorously discussed in a simple and authentic way. This book is a relevant source of knowledge, very useful for researchers, medical doctors, nurses, students and individuals interested in this complex disease
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    Advances in Pancreatic Cancer (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789236415 , 9781789236408 , 9781838816834
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Oncology
    Abstract: Pancreatic cancer is a growing source of cancer-related death and has poor survival rates, which have not improved in the last few decades. Its high-mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis, and lack of standardized international guidelines in assessing the pancreatic masses. This book aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of the available diagnostic technology and therapy. The main modalities for diagnosis are imaging with HCT, MRI, USE, and PET. Some chapters review the improvements in the techniques used. Timely and accurate diagnosis of pancreatic cancer can lead to improve in the current poor outcome of this disease
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  • 76
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    Hematology : Latest Research and Clinical Advances (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789233513 , 9781789233506 , 9781838814717
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Oncology
    Abstract: Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of blood diseases. This has in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options in hematology requires a frequent update of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research in hematological diseases with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients, as well as on some molecular and pathogenetic mechanisms and the respective translation into novel therapies
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  • 77
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    Cervical Cancer : Screening, Treatment and Prevention - Universal Protocols for Ultimate Control (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789231458 , 9781789231441 , 9781838814670
    Language: Undetermined
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Oncology
    Abstract: This book entitled Cervical Cancer - Screening, Treatment and Prevention Universal Protocols for Ultimate Control is the fourth successful endeavor of the Editor with InTech publisher. The four books serve as four pillars in cervical cancer control, globally. This book is unique and sensational. Public health "topics" are assuming a status of "phenomenon," through deliberations and research. Screening is riddled with global limitations of availability, affordability, acceptability, and accessibility. The treatment of precancers has questionable efficiency. Prevention is costly with the inclusion of HPV vaccine. This book helps to find the solutions. The authors, editor, and InTech publisher wish the readers a pleasant and purposeful reading. This book is a "readers' feast," "receivers' choice," and "respondents' delight." Enjoy and treasure the international facts and flavors
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  • 78
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    Thalassemia and Other Hemolytic Anemias (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789233674 , 9781789233667 , 9781838813406
    Language: Undetermined
    Pages: 1 Online-Ressource (138 p.)
    Keywords: Oncology
    Abstract: Thalassemia is a very common disease first described by pediatrician Thomas Benton Cooley in 1925 who described it in a patient of Italian origin. At that time, it was designated as Cooley's anemia. George Hoyt Whipple, a Nobel prize winner, and W. L. Bradford, a professor of pediatrics at the University of Rochester, coined the term thalassemia in 1936, which in Greek means anemia of the sea (Thalassa means "sea", and emia means "blood"), due to the fact that it is very common in the area of the Mediterranean Sea. This name is actually misleading because it can occur everywhere in the world. Thalassemia is not a single disease; it is rather a group of hereditary disorders of the production of globulin chain of the hemoglobin. Throughout the world, thalassemia affects approximately 4.4 of every 10,000 live births. It represents a major social and emotional impact on the patient and his family and a major burden on health services where the prevalence is high
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  • 79
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    Liver Cancer (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789844498 , 9781789844481 , 9781838817541
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Oncology
    Abstract: This book offers remarkable coverage of liver cancer from etiology to prevention and treatment. It provides an updated and new vision of this major cancer that continues to affect hundreds of thousands of people and remains one of the leading causes of cancer deaths around the world. To ensure the high quality of this book, important insights are included and rigorously discussed in a simple and authentic way. The book includes detailed and updated descriptions of the main causes of liver cancer and also the prevention and treatment of this disease. This book is a relevant source of knowledge, very useful for researchers, medical doctors, medical residents, students, healthcare providers, public health decision makers, and all individuals interested in the prevention of this disease
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  • 80
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    Brain Tumors : An Update (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789235579 , 9781789235562 , 9781838815097
    Language: Undetermined
    Pages: 1 Online-Ressource (248 p.)
    Keywords: Oncology
    Abstract: We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book "Brain Tumor - An Update" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book
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  • 81
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    Esophageal Cancer and Beyond (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789844139 , 9781789844122 , 9781838817602
    Language: Undetermined
    Pages: 1 Online-Ressource (92 p.)
    Keywords: Oncology
    Abstract: Human life relies on two basic supplies from nature: oxygen and food. Oxygen can be utilized directly, but food has to go through a process of digestion to become usable nutrients. The esophagus represents the beginning of this long journey. Because of its critical location, esophageal cancer is one of the deadliest malignancies in the world, and furthermore its incidence has been rising steadily year after year while other cancers are declining. It is predicted that by the year 2035 the esophageal cancer population will increase by 77.4% and become one of top global concerns. This book covers many aspects of esophageal cancer, through which we hope to raise the awareness of professionals as well as non-professionals about this disease
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  • 82
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    Ovarian Cancer : From Pathogenesis to Treatment (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789843347 , 9781789843330 , 9781838812669
    Language: Undetermined
    Pages: 1 Online-Ressource (364 p.)
    Keywords: Oncology
    Abstract: Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management
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  • 83
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    Human Skin Cancers : Pathways, Mechanisms, Targets and Treatments (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789230956 , 9781789230949 , 9781838812782
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Oncology
    Abstract: Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas
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  • 84
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    Lung Cancer : Strategies for Diagnosis and Treatment (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789843507 , 9781789843491 , 9781838816391
    Language: Undetermined
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Oncology
    Abstract: Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance development to current therapies, among others. Together with advances in the understanding of molecular features, factors, and mechanisms involved in initiation and tumor progression, important improvements have occurred in diagnostics and therapeutics in the shape of advances in molecular genotyping, procedures for sampling, new potential, and less invasive sources of samples for the diagnosis and development of new targeted therapies. The aim of this book is to provide an exciting read on strategies in the diagnosis and therapy of lung cancer
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  • 85
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    Cancer Management and Therapy (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789232998 , 9781789232981 , 9781838813017
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Oncology
    Abstract: There are many different types of cancer. Some are very common; others are rare. Having some similar features, each cancer has its own characteristics and symptoms, which vary according to the type of cancer and where it is in the body. The treatment selected may be influenced by the patient's age, concurrent health problems, life expectancy, characteristics of the individual's cancer, the patient's goals of treatment, and the bias of the treating physician. In preparing this book, we have considered and reflected on the concept of the recent advances in cancer management and therapy as well as molecular applications in cancer therapy. The readers can find detailed information about the treatment and management of specific cancers in these book chapters
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  • 86
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    Head and Neck Cancer : Diagnosis and Management of (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535134961 , 9789535134954 , 9789535146599
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Oncology
    Abstract: This book includes useful and recent information to the readers regarding the following topics: Signs and symptoms and etiology and risk factors of head and neck cancer, Epidemiology and the role of microRNAs in nasopharyngeal carcinoma and oral carcinogenesis, History, classifications, and managements of salivary gland cancer, Considerations, classifications, and managements of thyroid gland cancer, Updates in the diagnosis and management of medullary thyroid carcinoma, Interventional techniques used for the relief of head and neck cancer pain, Oral side effects of head and neck irradiation, Health-related quality of life in maxillectomy patients rehabilitated with obturator prostheses
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  • 87
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    Neuroblastoma : Current State and Recent Updates (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535135845 , 9789535135838 , 9789535146193
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Oncology
    Abstract: Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma
    Note: English
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  • 88
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    Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535133360 , 9789535133353 , 9789535147459
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Oncology
    Abstract: The aim of this book is to provide an overview of the importance of exosomes in the biomedical field, which involves in novel implications of exosomes in diagnosis and treatment of cancer and infectious diseases. The book would definitely be an ideal source of scientific information of exosomes to researchers and scientists involved in biomedicine, biology, and other areas involving cancer and infectious diseases
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  • 89
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    Updates in Liver Cancer (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535130642 , 9789535130635 , 9789535148852
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Oncology
    Abstract: Liver cancers result in considerable amount of financial and social burden. On the other hand, researches and clinical studies related to liver cancers continue to advance at a rapid pace. The chapters in this book provide state-of-the-art reviews on the current knowledge and advances in research and management of liver cancers. It includes the most recent advances in that field, particularly, hepatocarcinogenesis and the potential role of intestinal microbiota, nonalcoholic steatohepatitis, cancer stem cells, aldehyde dehydrogenase-1, and hepatitis B virus. This book also discusses the methods of diagnosis of HCC, the minimally invasive therapies for liver cancers, living donor liver transplantation for HCC, surgical management of liver metastases from colorectal cancers, and assessment and optimization for the future liver remnant
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  • 90
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    Neurooncology : Newer Developments (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535124269 , 9789535124252 , 9789535172857
    Language: English
    Pages: 1 Online-Ressource (488 p.)
    Keywords: Oncology
    Abstract: The book contains the information of various aspects of newer developments and recent advances in the field of central nervous system (CNS) tumor molecular biology, tumor progression, clinical presentation, imaging and management. The authors from different reputed institutions shared their knowledge on this open access platform to disseminate their knowledge at global level. As it is obvious in the current text, the field of neurooncology is heterogeneous and under continuous development with addition of new knowledge and information on regular basis. The collective contributions from experts attempt to provide updates regarding ongoing research and developments pertaining to CNS tumor genetics and molecular aspects and their applied aspect in reference to patient management
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  • 91
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    Thyroid Cancer : Advances in Diagnosis and Therapy (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535125891 , 9789535125884 , 9789535172987
    Language: English
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Oncology
    Abstract: Thyroid cancer is the eighth most common type of cancer and is most frequently diagnosed among people aged 45-54. Nearly three out of four cases are found in women, while about 2% of thyroid cancers occur in children and teenagers. This book is for medical doctors with experience in the field of thyroid cancer. It comprises different subjects, especially the advances in the diagnosis of thyroid cancer with PET imaging and elastography, as well as the new therapeutic approaches with tyrosine kinase inhibitors
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  • 92
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    New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122531 , 9789535143826 , 9789535172758
    Language: English
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Oncology
    Abstract: Written by an international team of experts in the field of human carcinogenesis, this book discusses recent advances in cancer research, which include the following topics: basic molecular and cellular mechanisms behind cancer growth, new approaches in cancer therapy, and cancer diagnostic. The book serves as a useful source of reference for cancer biologists, medical doctors, and clinical researchers in the fields of cancer diagnosis, prevention, and treatment
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  • 93
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    Role of Biomarkers in Medicine (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535125068 , 9789535125051 , 9789535154433
    Language: English
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Oncology
    Abstract: The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management
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  • 94
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    Free Radicals and Diseases (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535127475 , 9789535127468 , 9789535141655
    Language: Undetermined
    Pages: 1 Online-Ressource (386 p.)
    Keywords: Oncology
    Abstract: The current volume entitled, "Free Radicals and Diseases" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions
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  • 95
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    Human Skin Cancer, Potential Biomarkers and Therapeutic Targets (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535127116 , 9789535127109 , 9789535173175
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Oncology
    Abstract: Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several chapters focus on the posttranscriptional modification of the proteins at the melanocyte cell surface, their role in tumorigenesis, and their potential as therapeutic targets. Specifically, extracellular modifications of integrins, glycosylation of cell surface proteins, and changes of cadherins are presented. In a very interesting approach, a potential to target the mitochondria of melanoma cells is investigated. In conclusion, this volume presents various aspects of human skin cancers, components of the large worldwide effort to combat and eradicate this growing health concern
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  • 96
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    Tumor Metastasis (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535126317 , 9789535126300 , 9789535141815
    Language: Undetermined
    Pages: 1 Online-Ressource (266 p.)
    Keywords: Oncology
    Abstract: Metastasis is the major cause of cancer-related death. It is a multistep process. The mechanism underlying metastasis is complicated and poorly understood. Recent advances in tumor metastasis research have led to improved diagnosis and clinical management of cancer. However, new strategies on metastasis treatment are urgently needed, especially the novel biomarkers discovery and targeted therapy. This book is designed to present the most recent advances in tumor metastasis
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  • 97
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    Human Papillomavirus : Research in a Global Perspective (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535124405 , 9789535124399 , 9789535141976
    Language: Undetermined
    Pages: 1 Online-Ressource (318 p.)
    Keywords: Oncology
    Abstract: This book is a feast of knowledge, yet a balanced diet of healthy foods. There are high values of rich essential nutrients from top-quality medical research. But they are made easily digestible and absorbable, even by health care providers and planners, working in resource-limited settings, in all parts of the world, through social implications and community applications. All the chapters are value-added master pieces. The book would serve both as a scientific reference guide and a practical work manual. The authors, editor, and Intech publishers, together, are pleased to provide the readers a precious blend of scientific excellence and social relevance, for health empowerment, globally. We wish the readers great success, savoring science and sociology together
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  • 98
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    Drug Discovery and Development : From Molecules to Medicine (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535121282 , 9789535142225
    Language: Undetermined
    Pages: 1 Online-Ressource (330 p.)
    Keywords: Oncology
    Abstract: It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology
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  • 99
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    Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535120315 , 9789535172352
    Language: English
    Pages: 1 Online-Ressource (434 p.)
    Keywords: Oncology
    Abstract: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided
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  • 100
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    Contemporary Issues in Head and Neck Cancer Management (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535121350 , 9789535172468
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Oncology
    Abstract: While the management of head and neck cancer has evolved over the last few decades, there are still several challenges and unanswered questions that need solutions. This book is a small compilation of some topical aspects regarding head and neck cancer treatment, including the etiology of HPV-positive oropharyngeal cancers and risk factors in the young population, the challenge of surgical margin definition and the perennial problem of systemic treatment due to distant metastases. Radiobiological aspects are also covered through the Rs of radiotherapy, with a couple of chapters being dedicated to radioresistance and tumour microenvironment. Contemporary Issues in Head and Neck Cancer Management comes as an addition to the existing literature that aims to tackle this radiobiologically challenging tumour
    Note: English
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