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  • 1
    Online Resource
    Online Resource
    Transcriptome Analysis (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789843286 , 9781789843279 , 9781789852639
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analysis is most commonly used to compare specific pairs of samples, for example, tumor tissue versus its healthy counterpart. In this volume, Dr. Pyo Hong discusses the role of long RNA sequences in transcriptome analysis, Dr. Shinichi describes the next-generation single-cell sequencing technology developed by his team, Dr. Prasanta presents transcriptome analysis applied to rice under various environmental factors, Dr. Xiangyuan addresses the reproductive systems of flowering plants and Dr. Sadovsky compares codon usage in conifers
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 2
    Online Resource
    Online Resource
    Microorganisms (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838801885 , 9781838801878 , 9781838803636
    Language: English
    Pages: 1 Online-Ressource (318 p.)
    Keywords: Pathology
    Abstract: The recent breakthrough in microbial studies has applied next-generation sequencing (NGS), a massive omics analysis, to the composition and structure of microbial communities. NGS can identify microbes without the need for their cultivation. Their mere presence can be ascertained and often quantitated, and even their metabolic capabilities of microbial constituents predicted. This breakthrough led to an explosive growth in research on microbes. Many important advances have been made in human health-related studies. Indeed, gut microbial communities have been extensively analyzed and differences between healthy and diseased microbiomes have been determined. Studies of the effects of changes of diet, of antibiotic treatments, and of probiotics have been published. Specific attention has been devoted to human pathogens, their mechanisms of causing disease, and the potentials for their management and treatment. Microbiome studies of natural habitats, terrestrial and aquatic, have also benefited from NGS methodology. Increased understanding of the microbial communities has led to the use microbes as antagonists of pathogens, i.e. as treatments. Moreover, novel uses of microbes in industrial processes, either for synthesis of important compounds or for degradation and handling of waste, are being devised. In this volume, chapters dealing with the cutting-edge research in all these fields are presented
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 3
    Online Resource
    Online Resource
    Melanin (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535129806 , 9789535129790 , 9789535154723
    Language: Undetermined
    Pages: 1 Online-Ressource (114 p.)
    Keywords: Medical microbiology & virology
    Abstract: The word melanin refers to dark natural pigments produced by the oxidative degradation of tyrosine, catalyzed by tyrosinase, and polymerized into insoluble granular substance. The main function of melanin is to protect from harmful agents, primarily UV radiation, but also from oxidation, heavy metals, etc. In this volume, chapters deal with production of melanin in human oral mucosa (Liviu et al.), the regulation of melanin action (Cecile et al.), production and potential technological application of fungal melanins (Pombiero-Sponchiado et al.) and an innovative method for measuring melanin in various samples (Zdybel et al.). In conclusion, this volume presents various biological and industrial aspects of melanin production, uses and analysis
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 4
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    Online Resource
    Keratin (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789848052 , 9781789848045 , 9781838817275
    Language: Undetermined
    Pages: 1 Online-Ressource (180 p.)
    Series Statement: Biochemistry 2
    Keywords: Cellular biology (cytology)
    Abstract: Keratin is the proteinaceous body covering layer produced by mammals, birds, fish, reptiles, and amphibians. Hair and wool, horns, claws, hooves, feathers, and scales are made of keratin. Keratin is insoluble in water and is resistant to proteolysis. Importantly, keratin is also the intracellular structural protein that protects living epithelial cells from mechanical damage or stress. The fundamental keratin functions are revealed in congenital human skin diseases caused by mutations in keratin genes, e.g., Epidermolysis bullosa simplex or Epidermolytic hyperkeratosis. Most keratin gene mutations have a dominant-negative effect disrupting the filamentous structure formation even from the natural allele, and leaving the cell with a deficient cytoskeleton. However, industrial scale meat production results in vast quantities of keratin byproduct. Processing this byproduct is, on the one hand a major challenge, and on the other hand, a potential for useful recycling and exploitation
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 5
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    Online Resource
    Human Skin Cancers : Pathways, Mechanisms, Targets and Treatments (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789230956 , 9781789230949 , 9781838812782
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Oncology
    Abstract: Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 6
    Online Resource
    Online Resource
    Human Skin Cancer, Potential Biomarkers and Therapeutic Targets (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535127116 , 9789535127109 , 9789535173175
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Oncology
    Abstract: Skin cancers, basal and squamous cell carcinomas, malignant melanomas, and Merkel cell carcinomas, constitute arguably the most common and increasingly prevalent human neoplasms. Here we discuss the epigenetic changes in DNA and chromatin, which are increasingly associated with melanoma. Several chapters focus on the posttranscriptional modification of the proteins at the melanocyte cell surface, their role in tumorigenesis, and their potential as therapeutic targets. Specifically, extracellular modifications of integrins, glycosylation of cell surface proteins, and changes of cadherins are presented. In a very interesting approach, a potential to target the mitochondria of melanoma cells is investigated. In conclusion, this volume presents various aspects of human skin cancers, components of the large worldwide effort to combat and eradicate this growing health concern
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
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