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  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (132)
  • London : Routledge
  • Medical genetics  (132)
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  • 1
    Online Resource
    Online Resource
    BRCA1 and BRCA2 Mutations : Diagnostic and Therapeutic Implications (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803568072 , 9781803568065 , 9781803568089
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: Mutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants
    Note: English
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  • 2
    Online Resource
    Online Resource
    Oligonucleotides : Overview and Applications (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803556284 , 9781803556277 , 9781803556291
    Language: Undetermined
    Pages: 1 Online-Ressource (110 p.)
    Keywords: Medical genetics
    Abstract: Oligonucleotide-based diagnostics and therapeutics are attracting attention from the scientific community. In recent years, the range of applications for oligonucleotides has broadened in innovative and creative directions, such as disease diagnostics, cancer prognosis and more. It played an important role during the COVID pandemic in rapid PCR testing as well as modified mRNA-based life-saving vaccines. Various modifications of natural nucleotide bases have been evaluated for several theranostic applications. The development of nucleotide and oligonucleotide therapeutics has been growing in importance over the past few decades. This book examines new developments in oligonucleotide-based research and provides a comprehensive overview of the state of the art in this exciting discipline
    Note: English
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  • 3
    Online Resource
    Online Resource
    Genetic Diversity : Recent Advances and Applications (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803569451 , 9781803569444 , 9781803569468
    Language: Undetermined
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medical genetics
    Abstract: This book covers the dynamic process of genetic diversity in living organisms. It comprises eight chapters that address various topics, including genetic diversity in crop production, the relationship between viruses and their hosts, patterns of genetic variability in silver carp populations in Pakistan, molecular markers used for wildlife conservation, and more
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  • 4
    Online Resource
    Online Resource
    Epigenetics : Regulation and New Perspectives (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781837683949 , 9781837683932 , 9781837683956
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Medical genetics ; oxidative stress ; dna methylation ; cancer ; biomarkers ; aging ; microrna
    Abstract: Epigenetics plays a crucial role in regulating gene expression, particularly in the field of transcriptomics. Dysfunctions in epigenetics have been identified as key factors in the development of cancer and numerous complex diseases. This book presents the most recent advancements in epigenetics omics technologies and their utilization in understanding the mechanisms of cancer and complex diseases. We hope that this book will serve as an enlightening resource, broadening the horizons of our readers and motivating them to explore the potential of integrating multi-omics data for investigating epigenetic regulations in different biomedical scenarios
    Note: English
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  • 5
    Online Resource
    Online Resource
    Advances in Genetic Polymorphisms (2023)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781837696369 , 9781837696383 , 9781837696376
    Language: Undetermined
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Medical genetics ; SNP ; Mutations ; Genetic Tools ; PCR ; Susceptibility ; Human Diseases ; Prognosis ; Diagnosis ; Association ; Populations ; Precision Medicine ; Pharmacogenomics
    Abstract: The field of single nucleotide polymorphisms (SNPs) analysis has undergone impressive advancement, mainly due to the advent of modern high-throughput genotyping technologies and the emergence of innovative algorithms and computational methods, leading to exciting applications in human health. This book presents fundamental and recent aspects of SNP analysis techniques and applications in the new era of precision medicine. It includes six chapters that discuss a panoply of advanced aspects related to the clinical relevance of SNP analysis in diagnostic, prognostic, and predictive values in human health
    Note: English
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  • 6
    Online Resource
    Online Resource
    Mutagenesis and Mitochondrial-Associated Pathologies (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803551722 , 9781803551715 , 9781803551739
    Language: Undetermined
    Pages: 1 Online-Ressource (116 p.)
    Keywords: Medical genetics
    Abstract: Reactive oxygen species (ROS) and DNA double-strand breaks can result from mitochondrial defects and external sources, such as ionizing radiation. If not repaired properly, pathogenic mutations are generated. Human diseases resulting from inherited mitochondrial defects manifest in organs that physiologically require a high level of ATP synthesis. These diseases are clinically challenging, but new experimental clinical therapies include gene editing and mitochondrial transplants. Pathogenic ROS-associated cellular damage includes DNA double-strand breaks, and mouse models are now available to study multiple repair pathways. This book discusses the clinical manifestations of mitochondrial diseases in both the eye and the kidney, and presents new insights into double-strand break repair pathways and developmental phenotypes of g-ray-associated ontogenic mutations of Drosophila melanogaste
    Note: English
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  • 7
    Online Resource
    Online Resource
    Down Syndrome and Other Chromosome Abnormalities (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839693656 , 9781839693649 , 9781839693663
    Language: Undetermined
    Pages: 1 Online-Ressource (176 p.)
    Keywords: Medical genetics
    Abstract: This book provides a concise yet comprehensive source of current information on Down syndrome and other chromosomal abnormalities. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. Key features of this book are as follows: • Mechanisms of aneuploidy. • Effect of sociodemographic factors on different congenital disorders. • Haematological malignancies and congenital heart disease in Down syndrome. • Prenatal screening, management and counselling to detect Down syndrome and other chromosomal abnormalities. While aimed primarily at research workers on Down syndrome and different types of chromosomal disorders, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially the parents and relatives of children suffering from Down syndrome and other chromosomal abnormality syndromes
    Note: English
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  • 8
    Online Resource
    Online Resource
    p53 : A Guardian of the Genome and Beyond (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839681462 , 9781839681455 , 9781839681479
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: p53 is a protein that plays an important role in the regulation of cell division and thereby offers protection to the cell against malignant transformation. This is the most well-studied and most appreciated role of p53, due to which the protein is famously known as the “guardian of the genome.” It is the most studied protein in all forms of cancer research, with much of this research investigating p53’s role in tumor suppression. However, research has also shown that p53 plays a role in a wide range of other cellular functions, like serving as a biomarker for environmental pollution. Even as a tumor suppressor and transcription factor, many aspects of p53 function are still obscure, and research in the field is continually attempting to shed light on these functions. This book examines and discusses the myriad roles of p53 and different aspects of its functions. Chapters examine p53 in cancer prevention, DNA repair, gene regulation, and more
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  • 9
    Online Resource
    Online Resource
    Recent Advances in Noncoding RNAs (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803560151 , 9781803560144 , 9781803560168
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medical genetics
    Abstract: The discovery of noncoding RNAs (ncRNAs) is changed our understanding of genome, transcriptome, and interactions with proteome in a cell. Since the discovery of the first microRNA (miRNA) called lin-4 on Caenorhabditis elegans in 1993, our understanding of gene expression has deepened. Further miRNA discoveries have led to the investigation of new ncRNA families and their function, biogenesis, and interactions with other types of molecules. Recent developments in bioinformatics, public databases, sequencing technologies, and biochemical techniques have increased our understanding of the biogenesis, function, and interactions of ncRNAs. This book provides an overview of current ncRNA research dealing with human diseases and cancer and plant miRNAs
    Note: English
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  • 10
    Online Resource
    Online Resource
    Genetic Polymorphisms : New Insights (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839688119 , 9781839688102 , 9781839688126
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medical genetics
    Abstract: This book provides a glimpse into the dynamic process of genetic polymorphism by presenting studies carried out on different kinds of organisms at the DNA level or gene expression level. Chapters address such topics as genetic polymorphism in animals, gametocyte biomarkers, thrombotic disorders, prostate cancer, and more
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  • 11
    Online Resource
    Online Resource
    Synthetic Genomics : From BioBricks to Synthetic Genomes (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839696398 , 9781839696381 , 9781839696404
    Language: Undetermined
    Pages: 1 Online-Ressource (104 p.)
    Keywords: Medical genetics
    Abstract: The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field
    Note: English
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  • 12
    Online Resource
    Online Resource
    Epigenetics to Optogenetics : A New Paradigm in the Study of Biology (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838811235 , 9781838809935 , 9781838811242
    Language: Undetermined
    Pages: 1 Online-Ressource (176 p.)
    Series Statement: Biochemistry 35
    Keywords: Medical genetics
    Abstract: Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one can be used to change or modify the other. The complexity of the techniques involved in these disciplines often leads to a lack of proper understanding by researchers from other disciplines and the scientific community at large. As such, this book provides simple and easy-to-follow explanations of some of the most exciting areas of research in these disciplines
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  • 13
    Online Resource
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    Molecular Cloning (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803554518 , 9781803554501 , 9781803554525
    Language: Undetermined
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: This book examines the fundamentals of molecular cloning and molecular cloning applications in various areas. Chapters address such topics as tools and methodologies of molecular cloning, molecular cloning for medicine, food and feed, the environment, and the future of molecular cloning
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  • 14
    Online Resource
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    Population Genetics (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803553344 , 9781803553337 , 9781803553351
    Language: Undetermined
    Pages: 1 Online-Ressource (118 p.)
    Keywords: Medical genetics
    Abstract: Population genetics is a theoretical field of biology that studies allelic and genetic frequencies in living organisms, thus allowing us to infer what evolutionary processes are acting on individuals over generations and predict the adaptive consequences of these changes in the gene pool. Knowing the structure and genetic diversity of populations is essential for a proper understanding of the evolution, speciation processes, and dynamics of living beings. This knowledge is extremely useful for some practical applications, such as species management and conservation strategies, vector and pathogen monitoring and control, plant and animal breeding, and genetic improvement. This book includes carefully selected works in population genetics reviewed by geneticists
    Note: English
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  • 15
    Online Resource
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    Gene Expression (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803556222 , 9781803556215 , 9781803556239
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medical genetics
    Abstract: Gene expression is dependent on multiple steps, including transcription, RNA processing, and translation. Importantly, recent studies revealed that gene expression is regulated by chromatin structures and non-coding RNA profiles. Elucidating the molecular mechanisms may contribute to the development of novel therapeutics for aging-related diseases, including cancer and neurodegenerative diseases. This book provides a comprehensive overview of gene expression and its role in human disease. It consists of nine chapters organized into two sections on molecular mechanisms in controlling gene expression and the relationships between transcriptional control and human disease
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  • 16
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    Cytogenetics : Classical and Molecular Strategies for Analysing Heredity Material (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839689420 , 9781839689413 , 9781839689437
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medical genetics
    Abstract: This edited book, Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material, presents recent advances in the field of cytogenetics, paying special attention to methodological achievements developed worldwide that have driven the field forward. The contributors clearly discuss several concepts and approaches useful for understanding chromosomal structure and function at its various levels, highlighting chromosomes as visible carriers of heredity material
    Note: English
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  • 17
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    DNA : Damages and Repair Mechanisms (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838810948 , 9781838810931 , 9781838810955
    Language: Undetermined
    Pages: 1 Online-Ressource (234 p.)
    Keywords: Medical genetics
    Abstract: DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms
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  • 18
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    Genotoxicity and Mutagenicity : Mechanisms and Test Methods (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838800420 , 9781838800413 , 9781839621673
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: This edited book, “Genotoxicity and Mutagenicity - Mechanisms and Test Methods”, aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species
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  • 19
    Online Resource
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    Genetic Variation (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838810979 , 9781838810962 , 9781838811013
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medical genetics
    Abstract: Genetic diversity is one of the measures of biodiversity and has consequences in biological variation. It is crucial to understand the evolutionary and adaptative processes in all living species. This book is an interdisciplinary and integrated work that will contribute to the knowledge of academics from different areas of biological sciences. This collection of scientific papers was chosen and analyzed to offer readers a broad and integrated view of the importance of genetic diversity in the evolution and adaptation of living beings, as well as practical applications of the information needed to analyze this diversity in different organisms. This book was edited by geneticist researchers and provides academics with up-to-date and quality information on the subject
    Note: English
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  • 20
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    Chromatin and Epigenetics (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789844931 , 9781789844924 , 9781789849820
    Language: English
    Pages: 1 Online-Ressource (294 p.)
    Keywords: Medical genetics
    Abstract: Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general
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  • 21
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    Non-Coding RNAs (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789856569 , 9781789856552 , 9781789857085
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medical genetics
    Abstract: Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics
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  • 22
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    Gene Expression and Phenotypic Traits (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838800321 , 9781838800314 , 9781838803186
    Language: English
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medical genetics
    Abstract: Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits
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  • 23
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    The Recent Topics in Genetic Polymorphisms (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789858921 , 9781789858914 , 9781789846225
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medical genetics
    Abstract: The book in your hands presents chapters revealing the magnitude of genetic polymorphisms that exist in different kinds of living beings. Natural populations contain a considerable amount of genetic change, which provides a genomic flexibility that can be used as a raw material for adaptation to changing environmental conditions. The analysis of genetic polymorphisms provides information about DNA sequence changes at a given locus. The increasing availability of PCR-based molecular markers allows for the detailed analyses and the detection of genetic changes influencing some important traits. The purpose of this book is to provide a glimpse into the dynamic process of genetic polymorphisms by presenting the thoughts of scientists engaged in the generation of new ideas and techniques employed for the assessment of genetic polymorphisms. The book should prove useful to students, researchers and experts in the area of molecular genetics
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  • 24
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    Chromosomal Abnormalities (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789859805 , 9781789859799 , 9781839689789
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medical genetics
    Abstract: Chromosomes are vital components of genetic material, and, as such, distruption or changes to the structure of chromosomes can result in different health problems and deficits. This book explains chromosomal abnomalities and their effects on living organisms, including humans and plants. Classical and molecular cytogenetics techniques have a considerable number of potential applications, especially in clinical trials and biomedical diagnosis, making them a strong and insightful complement to other molecular and genomic approaches. Chapters cover topics including Down syndrome, fetal ultrasounds, acute myeloid leukemia, and Phelan-McDermid syndrome, among others
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  • 25
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    Mitochondria and Brain Disorders (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789855326 , 9781789855319 , 9781789856538
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Medical genetics
    Abstract: The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders
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  • 26
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    Genes and Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789844276 , 9781789844269 , 9781838819743
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Medical genetics
    Abstract: Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment
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  • 27
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    Animal Genetics : Approaches and Limitations (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789853766 , 9781789853759 , 9781839620461
    Language: English
    Pages: 1 Online-Ressource (64 p.)
    Keywords: Medical genetics
    Abstract: Animal genetics is a field of science with important theoretical and practical significance in finding the answers for the actual problems of mankind. We hope that the readers will discover some new facts regarding the relationship between plasma proteins and boar semen freezability, the importance of some behavioral factors that affect reproduction in horses, and also an important chapter regarding the use of genetically modified organisms for the repopulation of species of commercial importance in aquatic environments, their effect on the genetic pool, risks to protected areas, and policies for their proper management
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    Antisense Therapy (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845334 , 9781789845327 , 9781789852653
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Medical genetics
    Abstract: Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer. Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book summarizes and presents the best updates, therapeutic principles, methods, and applications in the field and offers meaningful information to move treatment discovery forward
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  • 29
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    Transcriptome Analysis (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789843286 , 9781789843279 , 9781789852639
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analysis is most commonly used to compare specific pairs of samples, for example, tumor tissue versus its healthy counterpart. In this volume, Dr. Pyo Hong discusses the role of long RNA sequences in transcriptome analysis, Dr. Shinichi describes the next-generation single-cell sequencing technology developed by his team, Dr. Prasanta presents transcriptome analysis applied to rice under various environmental factors, Dr. Xiangyuan addresses the reproductive systems of flowering plants and Dr. Sadovsky compares codon usage in conifers
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  • 30
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    Recent Advances in Phylogenetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789858907 , 9781789858891 , 9781839621185
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Keywords: Medical genetics
    Abstract: This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of phylogenetics. The book includes scholarly contributions by various authors, edited by experts pertinent to the field of phylogenetics. Each contribution comes as a separate chapter but is directly related to the book's topics and objectives. The target audience comprises scholars and specialists in the field
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  • 31
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    Gene Regulation (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789856842 , 9781789856835 , 9781839620799
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medical genetics
    Abstract: Genes store life data and information in genetic language. In accordance with the Central Dogma, life data are located in DNA sequences in the format of genes and the information is transcribed into transient molecules of RNA and finally the coding RNAs are translated into proteins. But the role of RNAs is pivotal. In other words, gene regulation (including expression or suppression) is an amazing and vital process that is composed of two central networks; DNAs and RNAs. Today, the principal and fundamental role of RNA molecules is revealed and it is known that the regulation of genes is directly controlled by DNA and RNA molecules. The diversity of RNAs in different cells and in particular Eukaryotic cells explains the importance of RNAs in gene regulation
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  • 32
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    Integrated View of Population Genetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789857788 , 9781789857771 , 9781839620898
    Language: English
    Pages: 1 Online-Ressource (70 p.)
    Keywords: Medical genetics
    Abstract: Population genetics is the basis of evolutionary studies, and has been widely used in several researches. This recent field of science has important applications for the management of populations (natural and domesticated), as well as for evolutionary studies of the various factors that affect gene frequencies over time and spatial distribution.In this work, presented in three sections (Population and Quantitative Genetics, Genetic Diversity in Crop Management, Population Genetics for Conservation Studies), the reader will find cutting-edge information in carefully selected and revised works.This book is intended for all researchers, academics, and students who are interested in the intriguing area of population genetics
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  • 33
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    Epigenetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789840889 , 9781789840872 , 9781838819705
    Language: English
    Pages: 1 Online-Ressource (96 p.)
    Keywords: Medical genetics
    Abstract: Epigenetic changes are heritable and reversible modifications that significantly affect gene expression without any change in DNA sequence. The epigenetic signature is remodelled during the lifespan as a direct consequence of both environment and lifestyle. Therefore, health or disease status strongly depends on epigenetic marks. This book summarizes the current knowledge in the field and includes chapters on epigenetics in plants and epigenetics in health and disease. It is written for a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding of epigenetics
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  • 34
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    Modern Medical Genetics and Genomics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839681431 , 9781839681424 , 9781839681448
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Keywords: Medical genetics
    Abstract: The field of medical genetics and genomics has been constantly revolutionized by new breakthroughs, which bring more knowledge into the etiology and help improve the health care of individuals with either rare or common diseases. Nevertheless, as technologies evolve, novel challenges emerge, both technically and ethically, so they must be prudentially addressed. Among the myriad applications of genomics in medicine, this book depicts a glimpse of the advances achieved that have been leading us to the personalized/precision medicine era
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  • 35
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    Gene Editing : Technologies and Applications (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845099 , 9781789845082 , 9781838806897
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed
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  • 36
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    Modulating Gene Expression : Abridging the RNAi and CRISPR-Cas9 Technologies (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838806972 , 9781838806965 , 9781838806989
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders
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  • 37
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    Cytogenetics : Past, Present and Further Perspectives (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838804060 , 9781838804053 , 9781838806439
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Medical genetics
    Abstract: Cytogenetics - Past, Present, and Further Perspectives discusses events that influenced the development of cytogenetics as a specialty within biology, with special attention paid to methodological achievements developed worldwide that have driven the field forward. Improvements to the resolution of chromosome analysis followed closely the introduction of innovative analytical technologies. In that sense, this book reviews and provides a brief account of the structure of chromosomes and stresses the high structural conservation in different species with an emphasis on aspects that require further research. However, it should be kept in mind that the future of cytogenetics will likely depend on improved knowledge of chromosome structure and function
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  • 38
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    Plasmid (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838802387 , 9781838802370 , 9781838811266
    Language: Undetermined
    Pages: 1 Online-Ressource (70 p.)
    Keywords: Medical genetics
    Abstract: This book captures in a single volume the wealth of information on the plasmid structure, function, and biology of all organisms that have been examined to date. Plasmids exhibit wide variations in size, modes of replication and transmission, host ranges, and the genes they carry and have provided us with a great understanding of basic life principles at the molecular level. Written by experts in the field, this book is a valuable source of up-to-date information, delivering the latest impacts on studies in the areas of plasmid types, genomes, purification analysis, and expression of recombinant proteins in bacteria. Plasmid utilization in the synthesis of plasmid-based vaccines, plasmids as genetic tools, and their applications in ecology and the evolutionary process are also covered. This book is a single source of valuable information for instructors and students in advanced undergraduate and graduate courses on plasmids. It will also appeal to researchers seeking to find new relationships between biological processes that are linked by plasmids to the environment
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  • 39
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    In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789857184 , 9781789857177 , 9781839620829
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medical genetics
    Abstract: Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis
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  • 40
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    Immunogenetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838803483 , 9781838803476 , 9781838811105
    Language: Undetermined
    Pages: 1 Online-Ressource (96 p.)
    Keywords: Medical genetics
    Abstract: Because genetic factors can impact immune responses, and immunogenetic associations serve as a predictor of disease development and as a biological indicator of disease progression, the study of immunogenetics is important to basic genetics and immunology, as well as to translational and individualized medicine.This book addresses a few but important issues on the subject of immunogenetics. First, it will review the role that human leukocyte antigen molecules play in the immune system and then take into consideration the effectiveness of Western blotting for the detection of immunologic proteins. The book will discuss studies on the immunogenetics of cancer and tuberculosis followed by implications for immunotherapy. Working separately, the book will also provide evidence that the application of immunogenetics has improved our understanding of brain and behavior disorders
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  • 41
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    DNA Repair : An Update (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781838807832 , 9781838807825 , 9781838807849
    Language: Undetermined
    Pages: 1 Online-Ressource (232 p.)
    Keywords: Medical genetics
    Abstract: This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability
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  • 42
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    Gene Expression and Control (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789855180 , 9781789855173 , 9781839621130
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Medical genetics
    Abstract: Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."
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  • 43
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    Muscular Dystrophies (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789238464 , 9781789238457 , 9781839622243
    Language: Undetermined
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Medical genetics
    Abstract: Skeletal muscle is a highly plastic organ that is modulated by various pathways controlling protein turnover. Muscle loss is common in muscular dystrophy, in which marked loss of various proteins such as the dystrophin-glycoprotein complex occurs around muscle fibers. This book provides a comprehensive overview of the various muscular dystrophies, including characteristics, diagnosis, and classification. General treatment of drugs (e.g. corticosteroids) and physical therapy for muscular dystrophies are discussed. In addition, current applications for cell and tissue engineering using muscle stem cells or gene therapy are introduced. This book also deals with the recent advances in appropriate models of drug screening using cell cultures or mammalian organs in vitro in this field
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  • 44
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    Antibody Engineering (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535138266 , 9789535138259 , 9789535139751
    Language: Undetermined
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Medical genetics
    Abstract: Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets
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  • 45
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    Mitochondrial Diseases (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789236750 , 9781789236743 , 9781838812720
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medical genetics
    Abstract: Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine
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  • 46
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    Mitochondrial DNA : New Insights (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789842661 , 9781789842654 , 9781838816438
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medical genetics
    Abstract: The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization
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  • 47
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    Advances in Research on Down Syndrome (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535137634 , 9789535137627 , 9789535140412
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medical genetics
    Abstract: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome
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  • 48
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    Gene Expression and Regulation in Mammalian Cells : Transcription Toward the Establishment of Novel Therapeutics (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535138686 , 9789535138679 , 9789535140993
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medical genetics
    Abstract: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases
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  • 49
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    Genetic Diversity and Disease Susceptibility (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789842029 , 9781789842012 , 9781838816711
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms
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  • 50
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    Transcriptional and Post-transcriptional Regulation (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789237924 , 9781789237917 , 9781838816414
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book
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  • 51
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    Gene Expression and Regulation in Mammalian Cells : Transcription From General Aspects (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535138563 , 9789535138556 , 9789535140955
    Language: Undetermined
    Pages: 1 Online-Ressource (334 p.)
    Keywords: Medical genetics
    Abstract: "Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells
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  • 52
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    Chromosomal Abnormalities : A Hallmark Manifestation of Genomic Instability (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535134749 , 9789535134732 , 9789535146872
    Language: Undetermined
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Medical genetics
    Abstract: This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process
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  • 53
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    Progress in Understanding Cystic Fibrosis (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535132929 , 9789535132912 , 9789535147367
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medical genetics
    Abstract: Congenital defects in humans are of greater concern, and in that line, cystic fibrosis (CF) has been one of the most complex diseases posing treatment challenge till date. Though it is a chronic condition, CF is closely associated with dysfunction of various organ systems of the human body, which in turn results in secondary infections by microbes. Decades of research by scientists worldwide has narrowed down the cause of CF to a single target gene. But the complexity of the disease is the prime impediment to finding a single-shot cure. Fortunately, the multidisciplinary approach toward understanding and management of the CF condition has certainly increased the level of life expectancy among CF patients. In particular, the "omics" and the "systems biology" approach have greatly widened the focal area for better understanding of the disease. This book includes a collection of interesting chapters contributed by eminent scientists around the world who have been striving to improve the life of those affected by CF
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    Phylogenetics (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535135029 , 9789535134992 , 9789535146636
    Language: Undetermined
    Pages: 1 Online-Ressource (120 p.)
    Keywords: Medical genetics
    Abstract: Phylogenetics aims to study the evolutionary relatedness of living organisms in our planet. Its application is extended to the key areas such as evolution, classification and taxonomy of living organisms; ecology, diversity, and conservation biology of agrobiocenosis; monitoring of pathogen spread, outbreaks and source of transmissions, forensic analyses, etc. Historically, phylogenetics studies were prevalently based on morphological features of species that helped to classify the 'Tree of Life' on Earth. Modern phylogenetics studies, however, rely more heavily on DNA sequences. In this Phylogenetics book, we aimed to present readers the latest developments in phylogenetics studies that highlight multi-kingdom systems, reticulated evolution and conservation biology of living organisms as well as 'omics'-based phylogenetics advances
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  • 55
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    The Role of Matrix Metalloproteinase in Human Body Pathologies (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535137184 , 9789535137177 , 9789535140139
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Medical genetics
    Abstract: Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body
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  • 56
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    Genetic Diversity (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535129509 , 9789535129493 , 9789535154709
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: Genetic diversity is the entire amount of genes and genotypes in a group of organisms and is of vital importance for their adaptation to different living conditions. If, for example, all humans were identical, the extinction of the entire kind could happen very fast. Let us care and nourish differences! The goal of this book is to present some of the contemporary thoughts on understandings of the genetic diversity patterns and their altering in a changing world. The book is aimed to the ones inspired to study and contemplate genetic diversity and to the audience beyond any frames
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  • 57
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    Senescence : Physiology or Pathology (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535134626 , 9789535134619 , 9789535146780
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medical genetics
    Abstract: In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence
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  • 58
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    Applications of RNA-Seq and Omics Strategies : From Microorganisms to Human Health (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535135043 , 9789535135036 , 9789535146520
    Language: Undetermined
    Pages: 1 Online-Ressource (328 p.)
    Keywords: Medical genetics
    Abstract: The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine
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  • 59
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    Genetic Polymorphisms (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535135166 , 9789535135159 , 9789535146735
    Language: Undetermined
    Pages: 1 Online-Ressource (280 p.)
    Keywords: Medical genetics
    Abstract: The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis
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  • 60
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    Flow Cytometry : Select Topics (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535125518 , 9789535125501 , 9789535154457
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: Flow cytometry - Select Topics is a collection of chapters that illustrate the constantly evolving application of flow cytometry to diverse areas of research or clinical investigations. It includes chapters on the utilization of flow cytometry in the fields of human reproduction and fertility, platelet function, apoptosis, inflammation research, leukemia immunophenotyping, and transplantation
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  • 61
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    Molecular Mechanisms of the Aging Process and Rejuvenation (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535125693 , 9789535125686 , 9789535154488
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Medical genetics
    Abstract: Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation
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  • 62
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    Plant Genomics (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535124566 , 9789535124559 , 9789535154402
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Medical genetics
    Abstract: Plant genomics aims to sequence, characterize, and study the genetic compositions, structures, organizations, functions, and interactions/networks of an entire plant genome. Its development and advances are tightly interconnected with proteomics, metabolomics, metagenomics, transgenomics, genomic selection, bioinformatics, epigenomics, phenomics, system biology, modern instrumentation, and robotics sciences. Plant genomics has significantly advanced over the past three decades in the land of inexpensive, high-throughput sequencing technologies and fully sequenced over 100 plant genomes. These advances have broad implications in every aspect of plant biology and breeding, powered with novel genomic selection and manipulation tools while generating many grand challenges and tasks ahead. This Plant genomics provides some updated discussions on current advances, challenges, and future perspectives of plant genome studies and applications
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    Next Generation Sequencing : Advances, Applications and Challenges (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122401 , 9789535154198
    Language: English
    Pages: 1 Online-Ressource (464 p.)
    Keywords: Medical genetics
    Abstract: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences
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  • 64
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    RNA Interference (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122722 , 9789535146148 , 9789535154297
    Language: English
    Pages: 1 Online-Ressource (458 p.)
    Keywords: Medical genetics
    Abstract: RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment
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  • 65
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    Restricted Growth : Clinical, Genetic and Molecular Aspects (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535126959 , 9789535126942 , 9789535173151
    Language: Undetermined
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Medical genetics
    Abstract: Restricted growth conditions are a group of genetic disorders with primary effect on growth (short stature); it is very heterogeneous and comprises two important categories: skeletal dysplasia and different genetic syndromes with primary effect on growth. It could also be caused by a medical condition. The book contains chapters regarding different aspects of the study of restricted growth that are divided into three broad sections. Section I: Defining Restricted Growth, Section II: Genetics and Diagnosis of Restricted Growth, and Section III: Signaling Pathways and Molecular Mechanisms of Restricted Growth. The book presents comprehensive reviews of each topic written by experts in the field. It will be the most valuable tool for physicians and life science researchers and students. We hope that the book will motivate discussion and research in this important health problem, setting the path for better therapeutic approaches
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    Telomere : A Complex End of a Chromosome (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535127536 , 9789535127529 , 9789535141501
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medical genetics
    Abstract: This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled
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    Microsatellite Markers (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535127987 , 9789535127970 , 9789535154600
    Language: Undetermined
    Pages: 1 Online-Ressource (252 p.)
    Keywords: Medical genetics
    Abstract: Microsatellite or so-called simple sequence repeat (SSR) markers have been one of the most reliable molecular markers derived from the DNA molecule, which were widely and successfully used for more than 25 years in the genetic studies of environmental, agricultural, and biomedical sciences. The objective of this Microsatellite Markers book is to rehighlight and provide some updates on previous and recent utilization of microsatellite markers for various applications in agriculture and medicine, which void emerging opinion on "full death" of microsatellites as useful genetic markers. Chapters presented here demonstrate the future benefit of SSRs in many genetic studies as well as disease diagnosis and prognosis
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    Gene Therapy : Principles and Challenges (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122210 , 9789535172680
    Language: English
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medical genetics
    Abstract: Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression
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    Health Problems in Down Syndrome (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535121541 , 9789535172529
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on diseases associated with Down syndrome. Inside, you will find state-of-the-art information on diseases associated with Down syndrome; improvement of cognitive skills in Down syndrome; and research approaches on Down syndrome. Although aimed primarily at research workers on Down syndrome, we hope that the appeal of this book extends beyond the narrow confines of academic interest and reaches a wider audience, especially parents, relatives, and health care providers who work with infants and children with Down syndrome
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    Plants for the Future (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535121855 , 9789535154099
    Language: English
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medical genetics
    Abstract: The world has come to understand only recently the importance of plants in our life. Therefore, we have brought together such book chapters that will help strengthen the scientific background of the readers on plants and deliver the message regarding plants for the future, in food security, health, industry, and other areas. This book will add to the scientific knowledge of the readers on the molecular aspects of plants
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    Cystic Fibrosis in the Light of New Research (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535121527 , 9789535172482
    Language: English
    Pages: 1 Online-Ressource (392 p.)
    Keywords: Medical genetics
    Abstract: Cystic Fibrosis in the Light of New Research provides the latest research and clinical evidence that will be useful for clinicians, scientists and researchers to further their knowledge around this fascinating condition. The authors have brought along their expertise and wealth of knowledge to produce this book, including the basic science that underlies the disease, the burden of bacterial and viral infections, immunologic aspects of CF, a variety of clinical measurements to predict prognosis and novel therapies including gene therapy. This book will be invaluable and entertaining for anyone who is involved in the care of patients with cystic fibrosis
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    Advances in DNA Repair (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122098 , 9789535142133
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medical genetics
    Abstract: This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair
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    Epigenetics and Epigenomics (2014)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535113638 , 9789535153917
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medical genetics
    Abstract: The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current understanding of the potential etiologies of Autism Spectrum Disorders. Additional chapters are devoted to DNA methylation, genomic imprinting and human reproduction. A discussion of the role of the epigenome in cancer prevention and polyphenols is also included. Authors provide research findings from both human data and animal model studies. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of epigenetics and epigenomics
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    Down Syndrome (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110361 , 9789535171102
    Language: English
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Medical genetics
    Abstract: Down syndrome, the most cutting-edge book in the field congenital disorders. This book features up-to-date, well referenced research and review articles on Down syndrome. Research workers, scientists, medical graduates and pediatricians will find it to be an excellent source for references and review. It is hoped that such individuals will view this book as a resource that can be consulted during all stages of their research and clinical investigations. Key features of this book are: Common diseases in Down syndrome Molecular Genetics Neurological Disorders Prenatal Diagnosis and Genetic Counselling Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents, relatives and health-care providers who work with infants and children with Down syndrome
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  • 75
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    Meiosis (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535111979 , 9789535153856
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: Meiosis is the key process underlying sexual reproduction in eukaryotes, occurring in single-celled eukaryotes and in most multicellular eukaryotes including animals and most plants. Thus meiosis is of considerable interest, both at the scientific level and at the level of natural human curiosity about sexual reproduction. Improved understanding of important aspects of meiosis has emerged in recent years and major questions are starting to be answered, such as: How does meiosis occur at the molecular level, How did meiosis and sex arise during evolution, What is the major adaptive function of meiosis and sex. In addition, changing perspectives on meiosis and sex have led to the question: How should meiosis be taught. This book proposes answers to these questions, with extensive supporting references to the current literature
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    The Mechanisms of DNA Replication (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535109914 , 9789535153573
    Language: English
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Medical genetics
    Abstract: DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations
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    Senescence and Senescence-Related Disorders (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535109976 , 9789535153580
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medical genetics
    Abstract: Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions
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    Chromatin Remodelling (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110873 , 9789535153672
    Language: English
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medical genetics
    Abstract: The term "chromatin remodelling" is widely used to describe changes in chromatin structure which is controlled by histone-modifying enzymes, chromatin remodelling complexes, non-histone DNA-binding proteins and noncoding RNAs. Many human diseases such as cancer, various genetic syndromes, autism and infectious disease have been linked to the disruption of these control processes by genetic, environmental or microbial factors. Therefore, to unravel the mechanisms by which they operate is one of the most exciting and rapid developing fields of modern biology and will contribute to new ways in treatment of these diseases. The chapters in this book will focus on recent advances in our understanding of the mechanisms that govern the dynamic structural of chromatin, thereby providing important insights into gene regulation, DNA repair, and human diseases
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    Gene Therapy : Tools and Potential Applications (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110149 , 9789535153627
    Language: English
    Pages: 1 Online-Ressource (756 p.)
    Keywords: Medical genetics
    Abstract: The Gene Therapy field is living exciting times after more than 20 years of poor results. Scientist and clinicians working in the gene therapy field have encountered many problems in the past that are now starting to be solved. The development of safer and more efficient gene transfer vectors and the advances on the cell therapy field have open new opportunities to tackle different diseases. The aim of this book is to bring together information about the different gene therapy tools, the clinical successes of gene therapy and the future applications
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    Genes and Autoimmunity : Intracellular Signaling and Microbiome Contribution (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110286 , 9789535171140
    Language: English
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medical genetics
    Abstract: Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity
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    Current Progress in Biological Research (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110972 , 9789535153689
    Language: English
    Pages: 1 Online-Ressource (396 p.)
    Keywords: Medical genetics
    Abstract: Current Progress in Biological Research presents new insights into key topics from different areas of the biological sciences. Some of the topics covered in the book are antibiotic susceptibility, genomic rearrangement, historical biogeography, biogeographic patterns, endemism and the use of microorganisms for pest control. The book is an interesting collection of 16 original research articles written by respected experts in their fields. It is hoped that readers will be stimulated and challenged by the contents of this book
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    Novel Gene Therapy Approaches (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535109662 , 9789535170853
    Language: English
    Pages: 1 Online-Ressource (406 p.)
    Keywords: Medical genetics
    Abstract: Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancer
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    Genetic Manipulation of DNA and Protein : Examples from Current Research (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535109945 , 9789535153528
    Language: English
    Pages: 1 Online-Ressource (464 p.)
    Keywords: Medical genetics
    Abstract: This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research
    Note: English
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    New Research Directions in DNA Repair (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535111146 , 9789535153757
    Language: English
    Pages: 1 Online-Ressource (674 p.)
    Keywords: Medical genetics
    Abstract: This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair
    Note: English
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    Genetic Disorders (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535108863 , 9789535170617
    Language: English
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medical genetics
    Abstract: Human genetics is the medical field with the most rapid progress. This book aims to provide an overview on some of the latest developments in several genetic diseases. It contains 14 chapters focused on various genetic disorders addressing epidemiology, etiology, molecular basis and novel treatment options for these diseases. The chapters were written by 41 collaborators, from 8 different countries in Europe, Asia, and America, with great expertise in their field. Chapters are heterogeneous, offering a welcomed personalized view on each particular subject. The book does not offer a systematic overview of human genetic disorders. However, they are a valuable resource for medical practitioners, researchers, biologists and students in various medical sciences
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    Reviews on Selected Topics of Telomere Biology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535108498 , 9789535153399
    Language: English
    Pages: 1 Online-Ressource (306 p.)
    Keywords: Medical genetics
    Abstract: Telomeres, located at the ends of linear chromosomes, are essential for genome stability and integrity. Advances in telomere researches have linked telomere dysfunction with cellular aging and a number of age-related human diseases. Recent studies further expanded our knowledge of telomere functions - telomeres are shown to be important for microbial pathogen virulence and telomere proteins have important non-telomeric cellular functions. This book includes current opinions on selected aspects of telomere research and their implication, in hope to help us focus better on future studies and enhance our research progress
    Note: English
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  • 87
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    Autoimmune Diseases : Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106937 , 9789535170204
    Language: English
    Pages: 1 Online-Ressource (404 p.)
    Keywords: Medical genetics
    Abstract: Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases
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  • 88
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    DNA Methylation : From Genomics to Technology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535103202 , 9789535152446
    Language: English
    Pages: 1 Online-Ressource (402 p.)
    Keywords: Medical genetics
    Abstract: Epigenetics is one of the most exciting and rapidly developing areas of modern genetics with applications in many disciplines from medicine to agriculture. The most common form of epigenetic modification is DNA methylation, which plays a key role in fundamental developmental processes such as embryogenesis and also in the response of organisms to a wide range of environmental stimuli. Indeed, epigenetics is increasing regarded as one of the major mechanisms used by animals and plants to modulate their genome and its expression to adapt to a wide range of environmental factors. This book brings together a group of experts at the cutting edge of research into DNA methylation and highlights recent advances in methodology and knowledge of underlying mechanisms of this most important of genetic processes. The reader will gain an understanding of the impact, significance and recent advances within the field of epigenetics with a focus on DNA methylation
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  • 89
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    Molecular Interactions (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100799 , 9789535152132
    Language: English
    Pages: 1 Online-Ressource (384 p.)
    Keywords: Medical genetics
    Abstract: In a classical approach materials science is mainly dealing with interatomic interactions within molecules, without paying much interest on weak intermolecular interactions. However, the variety of structures actually is the result of weak ordering because of noncovalent interactions. Indeed, for self-assembly to be possible in soft materials, it is evident that forces between molecules must be much weaker than covalent bonds between the atoms of a molecule. The weak intermolecular interactions responsible for molecular ordering in soft materials include hydrogen bonds, coordination bonds in ligands and complexes, ionic and dipolar interactions, van der Waals forces, and hydrophobic interactions. Recent evolutions in nanosciences and nanotechnologies provide strong arguments to support the opportunity and importance of the topics approached in this book, the fundamental and applicative aspects related to molecular interactions being of large interest in both research and innovative environments. We expect this book to have a strong impact at various education and research training levels, for young and experienced researchers from both academia and industry
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  • 90
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    Aneuploidy in Health and Disease (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106081 , 9789535152965
    Language: English
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Medical genetics
    Abstract: Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies
    Note: English
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  • 91
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    Point Mutation (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535103318 , 9789535152507
    Language: English
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medical genetics
    Abstract: This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world
    Note: English
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  • 92
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    Clinical Flow Cytometry : Emerging Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105756 , 9789535152958
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Medical genetics
    Abstract: "Clinical Flow Cytometry - Emerging Applications" contains a collection of reviews and original papers that illustrate the relevance of flow cytometry for the study of specific diseases and clinical evaluations. The chapters have been contributed by authors from a wide variety of countries showing the broad application and importance of this technology in medicine. Examples include chapters on autoimmune disease, cancer, and the evaluation of new drugs. The book is intended to give newcomers a helpful introduction, but also to provide experienced flow cytometrists with novel insights and a better understanding of clinical cytometry
    Note: English
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  • 93
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    Meiosis : Molecular Mechanisms and Cytogenetic Diversity (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101185 , 9789535152187
    Language: English
    Pages: 1 Online-Ressource (474 p.)
    Keywords: Medical genetics
    Abstract: Meiosis, the process of forming gametes in preparation for sexual reproduction, has long been a focus of intense study. Meiosis has been studied at the cytological, genetic, molecular and cellular levels. Studies in model systems have revealed common underlying mechanisms while in parallel, studies in diverse organisms have revealed the incredible variation in meiotic mechanisms. This book brings together many of the diverse strands of investigation into this fascinating and challenging field of biology
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    Antimicrobial Agents (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535107231 , 9789535153177
    Language: English
    Pages: 1 Online-Ressource (434 p.)
    Keywords: Medical genetics
    Abstract: This book contains precisely referenced chapters, emphasizing antibacterial agents with clinical practicality and alternatives to synthetic antibacterial agents through detailed reviews of diseases and their control using alternative approaches. The book aims at explaining bacterial diseases and their control via synthetic drugs replaced by chemicals obtained from different natural resources which present a future direction in the pharmaceutical industry. The book attempts to present emerging low cost and environmentally friendly drugs that are free from side effects studied in the overlapping disciplines of medicinal chemistry, biochemistry, microbiology and pharmacology
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    Osteogenesis (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100300 , 9789535168096
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Medical genetics
    Abstract: This book provides an in-depth overview of current knowledge about Osteogenesis, including molecular mechanisms, transcriptional regulators, scaffolds, cell biology, mechanical stimuli, vascularization and osteogenesis related diseases. Hopefully, the publication of this book will help researchers in this field to decide where to focus their future efforts, and provide an overview for surgeons and clinicians who wish to be directed in the developments related to this fascinating subject
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    Apoptosis and Medicine (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535107019 , 9789535153115
    Language: English
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medical genetics
    Abstract: This book looks at the latest research studies on apoptosis in medicine. It is divided into three sections for convenient and easy reading. The first section which comprises two chapters is an introduction of the subject of apoptosis to the uninitiated. The second section which comprises a single solitary chapter looks at apoptosis in normal physiology during bone resorption under mechanical stress. The third and the final section reviews apoptosis in a number of pathological conditions with an emphasis on cancer
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  • 97
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    Spinocerebellar Ataxia (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105428 , 9789535169772
    Language: English
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medical genetics
    Abstract: The purpose of this book has been to depict as many biochemical, genetic and molecular advances as possible, in the vast field of the spinocerebellar ataxias
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  • 98
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    Methylation : From DNA, RNA and Histones to Diseases and Treatment (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535108818 , 9789535153412
    Language: English
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Medical genetics
    Abstract: Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain
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    Studies in Population Genetics (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105886 , 9789535169895
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Medical genetics
    Abstract: This book deals with central concepts in population genetics, describing the main evolutionary processes that influence the allele frequency distribution and change. The different chapters discuss topics such as population size and structure, migration, inbreeding and interbreeding, mechanisms of extinction and speciation, along with different data techniques and molecular methods used for detecting DNA sequence variation in the study of genetic polymorphisms. Part of the book includes statistical and computational methods commonly used to process population genetics data, which constitute an essential tool for understanding the concepts discussed. The book will be a useful reference for graduate students and researchers working on population genetics, and other related areas including microbiology, genetics, molecular biology, ecology, anthropology and others
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    Recent Trends in Cytogenetic Studies : Methodologies and Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101789 , 9789535152231
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Keywords: Medical genetics
    Abstract: Recent Trends in Cytogenetic Studies - Methodologies and Applications deals with recent trends in cytogenetics with minute details of methodologies that can be adopted in clinical laboratories. The chapters deal with basic methods of primary cultures, cell lines and their applications; microtechnologies and automations; array CGH for the diagnosis of fetal conditions; approaches to acute lymphoblastic and myeloblastic leukemias in patients and survivors of atomic bomb exposure; use of digital image technology and using chromosomes as tools to discover biodiversity. While concentrating on the advanced methodologies in cytogenetic studies and their applications, authors have pointed out the need to develop cytogenetic labs with modern tools to facilitate precise and effective diagnosis to benefit the patient population
    Note: English
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