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  • 2015-2019  (47)
  • 1965-1969
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (47)
  • Cambridge [u.a.] : Cambridge Univ. Press
  • Medical genetics  (47)
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Material
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Year
Author, Corporation
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Keywords
  • 1
    Online Resource
    Online Resource
    DNA Repair : An Update (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838807832 , 9781838807825 , 9781838807849
    Language: Undetermined
    Pages: 1 Online-Ressource (232 p.)
    Keywords: Medical genetics
    Abstract: This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability
    Note: English
    URL: kostenfrei
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  • 2
    Online Resource
    Online Resource
    Muscular Dystrophies (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789238464 , 9781789238457 , 9781839622243
    Language: Undetermined
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Medical genetics
    Abstract: Skeletal muscle is a highly plastic organ that is modulated by various pathways controlling protein turnover. Muscle loss is common in muscular dystrophy, in which marked loss of various proteins such as the dystrophin-glycoprotein complex occurs around muscle fibers. This book provides a comprehensive overview of the various muscular dystrophies, including characteristics, diagnosis, and classification. General treatment of drugs (e.g. corticosteroids) and physical therapy for muscular dystrophies are discussed. In addition, current applications for cell and tissue engineering using muscle stem cells or gene therapy are introduced. This book also deals with the recent advances in appropriate models of drug screening using cell cultures or mammalian organs in vitro in this field
    Note: English
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  • 3
    Online Resource
    Online Resource
    Immunogenetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838803483 , 9781838803476 , 9781838811105
    Language: Undetermined
    Pages: 1 Online-Ressource (96 p.)
    Keywords: Medical genetics
    Abstract: Because genetic factors can impact immune responses, and immunogenetic associations serve as a predictor of disease development and as a biological indicator of disease progression, the study of immunogenetics is important to basic genetics and immunology, as well as to translational and individualized medicine.This book addresses a few but important issues on the subject of immunogenetics. First, it will review the role that human leukocyte antigen molecules play in the immune system and then take into consideration the effectiveness of Western blotting for the detection of immunologic proteins. The book will discuss studies on the immunogenetics of cancer and tuberculosis followed by implications for immunotherapy. Working separately, the book will also provide evidence that the application of immunogenetics has improved our understanding of brain and behavior disorders
    Note: English
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  • 4
    Online Resource
    Online Resource
    Plasmid (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838802387 , 9781838802370 , 9781838811266
    Language: Undetermined
    Pages: 1 Online-Ressource (70 p.)
    Keywords: Medical genetics
    Abstract: This book captures in a single volume the wealth of information on the plasmid structure, function, and biology of all organisms that have been examined to date. Plasmids exhibit wide variations in size, modes of replication and transmission, host ranges, and the genes they carry and have provided us with a great understanding of basic life principles at the molecular level. Written by experts in the field, this book is a valuable source of up-to-date information, delivering the latest impacts on studies in the areas of plasmid types, genomes, purification analysis, and expression of recombinant proteins in bacteria. Plasmid utilization in the synthesis of plasmid-based vaccines, plasmids as genetic tools, and their applications in ecology and the evolutionary process are also covered. This book is a single source of valuable information for instructors and students in advanced undergraduate and graduate courses on plasmids. It will also appeal to researchers seeking to find new relationships between biological processes that are linked by plasmids to the environment
    Note: English
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  • 5
    Online Resource
    Online Resource
    In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789857184 , 9781789857177 , 9781839620829
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medical genetics
    Abstract: Ongoing advances in pharmaceutical biotechnology have paved the way to ground-breaking new biological therapeutic modalities, offering the possibility of a durable curative approach for a number of life-threatening diseases, for which the medical need is as yet unmet. Over the past decades, gene therapy has seen a massive transformation from a proof-of-concept approach to a clinical reality culminating in the regulatory approval of state-of-the-art products in the European Union and in the United States. This book captures some of the scientific progresses notably in gene transfer technologies and translational development of in vivo and ex vivo gene therapy interventions in the treatment of a broad range of complex and debilitating non-inherited and inherited disorders such as: human immunodeficiency virus 1 (HIV-1) infection, cancer, cystic fibrosis, hereditary retinopathies, haemophilia B, cardiac diseases, and chronic liver fibrosis
    Note: English
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  • 6
    Online Resource
    Online Resource
    Cytogenetics : Past, Present and Further Perspectives (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838804060 , 9781838804053 , 9781838806439
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Medical genetics
    Abstract: Cytogenetics - Past, Present, and Further Perspectives discusses events that influenced the development of cytogenetics as a specialty within biology, with special attention paid to methodological achievements developed worldwide that have driven the field forward. Improvements to the resolution of chromosome analysis followed closely the introduction of innovative analytical technologies. In that sense, this book reviews and provides a brief account of the structure of chromosomes and stresses the high structural conservation in different species with an emphasis on aspects that require further research. However, it should be kept in mind that the future of cytogenetics will likely depend on improved knowledge of chromosome structure and function
    Note: English
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  • 7
    Online Resource
    Online Resource
    Modulating Gene Expression : Abridging the RNAi and CRISPR-Cas9 Technologies (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838806972 , 9781838806965 , 9781838806989
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders
    Note: English
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  • 8
    Online Resource
    Online Resource
    Gene Expression and Control (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789855180 , 9781789855173 , 9781839621130
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Medical genetics
    Abstract: Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."
    Note: English
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  • 9
    Online Resource
    Online Resource
    Animal Genetics : Approaches and Limitations (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789853766 , 9781789853759 , 9781839620461
    Language: English
    Pages: 1 Online-Ressource (64 p.)
    Keywords: Medical genetics
    Abstract: Animal genetics is a field of science with important theoretical and practical significance in finding the answers for the actual problems of mankind. We hope that the readers will discover some new facts regarding the relationship between plasma proteins and boar semen freezability, the importance of some behavioral factors that affect reproduction in horses, and also an important chapter regarding the use of genetically modified organisms for the repopulation of species of commercial importance in aquatic environments, their effect on the genetic pool, risks to protected areas, and policies for their proper management
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  • 10
    Online Resource
    Online Resource
    Transcriptome Analysis (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789843286 , 9781789843279 , 9781789852639
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analysis is most commonly used to compare specific pairs of samples, for example, tumor tissue versus its healthy counterpart. In this volume, Dr. Pyo Hong discusses the role of long RNA sequences in transcriptome analysis, Dr. Shinichi describes the next-generation single-cell sequencing technology developed by his team, Dr. Prasanta presents transcriptome analysis applied to rice under various environmental factors, Dr. Xiangyuan addresses the reproductive systems of flowering plants and Dr. Sadovsky compares codon usage in conifers
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  • 11
    Online Resource
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    Epigenetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789840889 , 9781789840872 , 9781838819705
    Language: English
    Pages: 1 Online-Ressource (96 p.)
    Keywords: Medical genetics
    Abstract: Epigenetic changes are heritable and reversible modifications that significantly affect gene expression without any change in DNA sequence. The epigenetic signature is remodelled during the lifespan as a direct consequence of both environment and lifestyle. Therefore, health or disease status strongly depends on epigenetic marks. This book summarizes the current knowledge in the field and includes chapters on epigenetics in plants and epigenetics in health and disease. It is written for a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding of epigenetics
    Note: English
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  • 12
    Online Resource
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    Integrated View of Population Genetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789857788 , 9781789857771 , 9781839620898
    Language: English
    Pages: 1 Online-Ressource (70 p.)
    Keywords: Medical genetics
    Abstract: Population genetics is the basis of evolutionary studies, and has been widely used in several researches. This recent field of science has important applications for the management of populations (natural and domesticated), as well as for evolutionary studies of the various factors that affect gene frequencies over time and spatial distribution.In this work, presented in three sections (Population and Quantitative Genetics, Genetic Diversity in Crop Management, Population Genetics for Conservation Studies), the reader will find cutting-edge information in carefully selected and revised works.This book is intended for all researchers, academics, and students who are interested in the intriguing area of population genetics
    Note: English
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  • 13
    Online Resource
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    Modern Medical Genetics and Genomics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839681431 , 9781839681424 , 9781839681448
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Keywords: Medical genetics
    Abstract: The field of medical genetics and genomics has been constantly revolutionized by new breakthroughs, which bring more knowledge into the etiology and help improve the health care of individuals with either rare or common diseases. Nevertheless, as technologies evolve, novel challenges emerge, both technically and ethically, so they must be prudentially addressed. Among the myriad applications of genomics in medicine, this book depicts a glimpse of the advances achieved that have been leading us to the personalized/precision medicine era
    Note: English
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  • 14
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    Antisense Therapy (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845334 , 9781789845327 , 9781789852653
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Medical genetics
    Abstract: Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer. Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book summarizes and presents the best updates, therapeutic principles, methods, and applications in the field and offers meaningful information to move treatment discovery forward
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  • 15
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    Gene Regulation (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789856842 , 9781789856835 , 9781839620799
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medical genetics
    Abstract: Genes store life data and information in genetic language. In accordance with the Central Dogma, life data are located in DNA sequences in the format of genes and the information is transcribed into transient molecules of RNA and finally the coding RNAs are translated into proteins. But the role of RNAs is pivotal. In other words, gene regulation (including expression or suppression) is an amazing and vital process that is composed of two central networks; DNAs and RNAs. Today, the principal and fundamental role of RNA molecules is revealed and it is known that the regulation of genes is directly controlled by DNA and RNA molecules. The diversity of RNAs in different cells and in particular Eukaryotic cells explains the importance of RNAs in gene regulation
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  • 16
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    Genes and Cancer (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789844276 , 9781789844269 , 9781838819743
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Medical genetics
    Abstract: Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment
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  • 17
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    Recent Advances in Phylogenetics (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789858907 , 9781789858891 , 9781839621185
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Keywords: Medical genetics
    Abstract: This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of phylogenetics. The book includes scholarly contributions by various authors, edited by experts pertinent to the field of phylogenetics. Each contribution comes as a separate chapter but is directly related to the book's topics and objectives. The target audience comprises scholars and specialists in the field
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  • 18
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    Gene Editing : Technologies and Applications (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845099 , 9781789845082 , 9781838806897
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed
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  • 19
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    Gene Expression and Regulation in Mammalian Cells : Transcription Toward the Establishment of Novel Therapeutics (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535138686 , 9789535138679 , 9789535140993
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medical genetics
    Abstract: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases
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  • 20
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    Transcriptional and Post-transcriptional Regulation (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789237924 , 9781789237917 , 9781838816414
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book
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  • 21
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    Gene Expression and Regulation in Mammalian Cells : Transcription From General Aspects (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535138563 , 9789535138556 , 9789535140955
    Language: Undetermined
    Pages: 1 Online-Ressource (334 p.)
    Keywords: Medical genetics
    Abstract: "Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells
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  • 22
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    Antibody Engineering (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535138266 , 9789535138259 , 9789535139751
    Language: Undetermined
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Medical genetics
    Abstract: Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets
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  • 23
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    Advances in Research on Down Syndrome (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535137634 , 9789535137627 , 9789535140412
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medical genetics
    Abstract: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on chromosome editing, neurogenomics and diseases associated with Down syndrome. Research workers, scientists, medical graduates and physicians will find this book as an excellent source for consultation and references. Key features of this book are chromosome engineering in Down syndrome, mental retardation and cognitive disability, prenatal diagnosis and diseases associated with Down syndrome. Although aimed primarily for research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be exciting to wider audience, especially parents, relatives and health care providers who work with infants and children with Down syndrome
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  • 24
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    Mitochondrial Diseases (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789236750 , 9781789236743 , 9781838812720
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medical genetics
    Abstract: Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine
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  • 25
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    Genetic Diversity and Disease Susceptibility (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789842029 , 9781789842012 , 9781838816711
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms
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  • 26
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    Mitochondrial DNA : New Insights (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789842661 , 9781789842654 , 9781838816438
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medical genetics
    Abstract: The very short genomes of mitochondria summarize the complexity of molecular biology and its interactions with cellular and whole organism biology. Studies of mitogenomes contribute to the understanding of molecular biology and evolution, and to health management. Despite or even due to their small sizes, mitogenomes continue to surprise us. Studies of mitogenomes reveal the details of molecular organization and its evolution under constraints for miniaturization
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  • 27
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    The Role of Matrix Metalloproteinase in Human Body Pathologies (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535137184 , 9789535137177 , 9789535140139
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Medical genetics
    Abstract: Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body
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    Genetic Diversity (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535129509 , 9789535129493 , 9789535154709
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: Genetic diversity is the entire amount of genes and genotypes in a group of organisms and is of vital importance for their adaptation to different living conditions. If, for example, all humans were identical, the extinction of the entire kind could happen very fast. Let us care and nourish differences! The goal of this book is to present some of the contemporary thoughts on understandings of the genetic diversity patterns and their altering in a changing world. The book is aimed to the ones inspired to study and contemplate genetic diversity and to the audience beyond any frames
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  • 29
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    Senescence : Physiology or Pathology (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535134626 , 9789535134619 , 9789535146780
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medical genetics
    Abstract: In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence
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  • 30
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    Applications of RNA-Seq and Omics Strategies : From Microorganisms to Human Health (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535135043 , 9789535135036 , 9789535146520
    Language: Undetermined
    Pages: 1 Online-Ressource (328 p.)
    Keywords: Medical genetics
    Abstract: The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine
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  • 31
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    Chromosomal Abnormalities : A Hallmark Manifestation of Genomic Instability (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535134749 , 9789535134732 , 9789535146872
    Language: Undetermined
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Medical genetics
    Abstract: This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process
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  • 32
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    Genetic Polymorphisms (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535135166 , 9789535135159 , 9789535146735
    Language: Undetermined
    Pages: 1 Online-Ressource (280 p.)
    Keywords: Medical genetics
    Abstract: The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis
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  • 33
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    Phylogenetics (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535135029 , 9789535134992 , 9789535146636
    Language: Undetermined
    Pages: 1 Online-Ressource (120 p.)
    Keywords: Medical genetics
    Abstract: Phylogenetics aims to study the evolutionary relatedness of living organisms in our planet. Its application is extended to the key areas such as evolution, classification and taxonomy of living organisms; ecology, diversity, and conservation biology of agrobiocenosis; monitoring of pathogen spread, outbreaks and source of transmissions, forensic analyses, etc. Historically, phylogenetics studies were prevalently based on morphological features of species that helped to classify the 'Tree of Life' on Earth. Modern phylogenetics studies, however, rely more heavily on DNA sequences. In this Phylogenetics book, we aimed to present readers the latest developments in phylogenetics studies that highlight multi-kingdom systems, reticulated evolution and conservation biology of living organisms as well as 'omics'-based phylogenetics advances
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  • 34
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    Progress in Understanding Cystic Fibrosis (2017)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535132929 , 9789535132912 , 9789535147367
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medical genetics
    Abstract: Congenital defects in humans are of greater concern, and in that line, cystic fibrosis (CF) has been one of the most complex diseases posing treatment challenge till date. Though it is a chronic condition, CF is closely associated with dysfunction of various organ systems of the human body, which in turn results in secondary infections by microbes. Decades of research by scientists worldwide has narrowed down the cause of CF to a single target gene. But the complexity of the disease is the prime impediment to finding a single-shot cure. Fortunately, the multidisciplinary approach toward understanding and management of the CF condition has certainly increased the level of life expectancy among CF patients. In particular, the "omics" and the "systems biology" approach have greatly widened the focal area for better understanding of the disease. This book includes a collection of interesting chapters contributed by eminent scientists around the world who have been striving to improve the life of those affected by CF
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  • 35
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    Molecular Mechanisms of the Aging Process and Rejuvenation (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535125693 , 9789535125686 , 9789535154488
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Medical genetics
    Abstract: Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation
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  • 36
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    Plant Genomics (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535124566 , 9789535124559 , 9789535154402
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Medical genetics
    Abstract: Plant genomics aims to sequence, characterize, and study the genetic compositions, structures, organizations, functions, and interactions/networks of an entire plant genome. Its development and advances are tightly interconnected with proteomics, metabolomics, metagenomics, transgenomics, genomic selection, bioinformatics, epigenomics, phenomics, system biology, modern instrumentation, and robotics sciences. Plant genomics has significantly advanced over the past three decades in the land of inexpensive, high-throughput sequencing technologies and fully sequenced over 100 plant genomes. These advances have broad implications in every aspect of plant biology and breeding, powered with novel genomic selection and manipulation tools while generating many grand challenges and tasks ahead. This Plant genomics provides some updated discussions on current advances, challenges, and future perspectives of plant genome studies and applications
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  • 37
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    Flow Cytometry : Select Topics (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535125518 , 9789535125501 , 9789535154457
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: Flow cytometry - Select Topics is a collection of chapters that illustrate the constantly evolving application of flow cytometry to diverse areas of research or clinical investigations. It includes chapters on the utilization of flow cytometry in the fields of human reproduction and fertility, platelet function, apoptosis, inflammation research, leukemia immunophenotyping, and transplantation
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  • 38
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    RNA Interference (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535122722 , 9789535146148 , 9789535154297
    Language: English
    Pages: 1 Online-Ressource (458 p.)
    Keywords: Medical genetics
    Abstract: RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment
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  • 39
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    Next Generation Sequencing : Advances, Applications and Challenges (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535122401 , 9789535154198
    Language: English
    Pages: 1 Online-Ressource (464 p.)
    Keywords: Medical genetics
    Abstract: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences
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  • 40
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    Telomere : A Complex End of a Chromosome (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535127536 , 9789535127529 , 9789535141501
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medical genetics
    Abstract: This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled
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  • 41
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    Microsatellite Markers (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535127987 , 9789535127970 , 9789535154600
    Language: Undetermined
    Pages: 1 Online-Ressource (252 p.)
    Keywords: Medical genetics
    Abstract: Microsatellite or so-called simple sequence repeat (SSR) markers have been one of the most reliable molecular markers derived from the DNA molecule, which were widely and successfully used for more than 25 years in the genetic studies of environmental, agricultural, and biomedical sciences. The objective of this Microsatellite Markers book is to rehighlight and provide some updates on previous and recent utilization of microsatellite markers for various applications in agriculture and medicine, which void emerging opinion on "full death" of microsatellites as useful genetic markers. Chapters presented here demonstrate the future benefit of SSRs in many genetic studies as well as disease diagnosis and prognosis
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  • 42
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    Restricted Growth : Clinical, Genetic and Molecular Aspects (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535126959 , 9789535126942 , 9789535173151
    Language: Undetermined
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Medical genetics
    Abstract: Restricted growth conditions are a group of genetic disorders with primary effect on growth (short stature); it is very heterogeneous and comprises two important categories: skeletal dysplasia and different genetic syndromes with primary effect on growth. It could also be caused by a medical condition. The book contains chapters regarding different aspects of the study of restricted growth that are divided into three broad sections. Section I: Defining Restricted Growth, Section II: Genetics and Diagnosis of Restricted Growth, and Section III: Signaling Pathways and Molecular Mechanisms of Restricted Growth. The book presents comprehensive reviews of each topic written by experts in the field. It will be the most valuable tool for physicians and life science researchers and students. We hope that the book will motivate discussion and research in this important health problem, setting the path for better therapeutic approaches
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  • 43
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    Plants for the Future (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535121855 , 9789535154099
    Language: English
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medical genetics
    Abstract: The world has come to understand only recently the importance of plants in our life. Therefore, we have brought together such book chapters that will help strengthen the scientific background of the readers on plants and deliver the message regarding plants for the future, in food security, health, industry, and other areas. This book will add to the scientific knowledge of the readers on the molecular aspects of plants
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  • 44
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    Health Problems in Down Syndrome (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535121541 , 9789535172529
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on diseases associated with Down syndrome. Inside, you will find state-of-the-art information on diseases associated with Down syndrome; improvement of cognitive skills in Down syndrome; and research approaches on Down syndrome. Although aimed primarily at research workers on Down syndrome, we hope that the appeal of this book extends beyond the narrow confines of academic interest and reaches a wider audience, especially parents, relatives, and health care providers who work with infants and children with Down syndrome
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  • 45
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    Gene Therapy : Principles and Challenges (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122210 , 9789535172680
    Language: English
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medical genetics
    Abstract: Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression
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  • 46
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    Cystic Fibrosis in the Light of New Research (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535121527 , 9789535172482
    Language: English
    Pages: 1 Online-Ressource (392 p.)
    Keywords: Medical genetics
    Abstract: Cystic Fibrosis in the Light of New Research provides the latest research and clinical evidence that will be useful for clinicians, scientists and researchers to further their knowledge around this fascinating condition. The authors have brought along their expertise and wealth of knowledge to produce this book, including the basic science that underlies the disease, the burden of bacterial and viral infections, immunologic aspects of CF, a variety of clinical measurements to predict prognosis and novel therapies including gene therapy. This book will be invaluable and entertaining for anyone who is involved in the care of patients with cystic fibrosis
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    Advances in DNA Repair (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122098 , 9789535142133
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medical genetics
    Abstract: This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair
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