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  • 1
    Online Resource
    Online Resource
    Test No. 205: Avian Dietary Toxicity Test (1984)
    Paris : OECD Publishing
    Details
    ISBN: 9789264070004
    Language: English
    Pages: Online-Ressource (10 p.)
    Series Statement: OECD Guidelines for the Testing of Chemicals, Section 2
    Parallel Title: Parallelausg. Essai n 205; Oiseaux, essai de toxicité liée au régime alimentaire
    Parallel Title: Parallelausg. Essai n 205: Oiseaux, essai de toxicité liée au régime alimentaire
    Keywords: Environment
    Abstract: The purpose of this Test Guideline is to determine the effects of a substance administered with food to birds. Birds are fed a diet containing the test substance at a range of concentrations for a period of five days. Two control groups and one treatment group for each of the, at least, five dietary levels of the test substance should be used. Each group consists of 10 birds. The minimum duration of the test is eight days: five days on the test diet followed by a minimum of three days on normal diet. Suitable facilities for holding birds indoors are necessary. These include mechanisms for temperature, humidity and light control as required, as well as pens of suitable capacity for rearing the birds. Mortalities and signs of toxicity are recorded daily. The following observations should be made during the test: signs of intoxication and other abnormal behaviour; mortality; body weights; food consumption.
    DOI: 10.1787/9789264070004-en
    URL: Volltext
    URL: lizenzpflichtig
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  • 2
    Online Resource
    Online Resource
    Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test (1984)
    Paris : OECD Publishing
    Details
    ISBN: 9789264071360
    Language: English
    Pages: Online-Ressource (6 p.)
    Series Statement: OECD Guidelines for the Testing of Chemicals, Section 4
    Parallel Title: Parallelausg. Essai n 478; Toxicologie génétique; Essai de mutation létale dominante chez le rongeur
    Parallel Title: Parallelausg. Essai n 478: Toxicologie génétique: Essai de mutation létale dominante chez le rongeur
    Keywords: Environment
    Abstract: Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, …) indicates that the substance has affected germinal tissue of the test species. Dominant lethals are generally accepted to be the result of chromosomal aberrations (structural and numerical anomalies), but gene mutations and toxic effects cannot be excluded. This Test Guideline recommends rats or mice as the test species. Generally, male animals are exposed to the test substance and mated to untreated virgin females. The most widely used is the single administration of the test substance by oral or by intraperitoneal injection. Normally, three dose levels should be used. The various germ cell stages can be tested separately by the use of sequential mating intervals. The females are sacrificed after an appropriate period of time, and the contents of the uteri are examined to determine the numbers of implants and live and dead embryos. The calculation of the dominant lethal effect is based on comparison of the live implants per female in the treated group to the live implants per female in the control group.
    DOI: 10.1787/9789264071360-en
    URL: Volltext
    URL: lizenzpflichtig
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  • 3
    Online Resource
    Online Resource
    Test No. 206: Avian Reproduction Test (1984)
    Paris : OECD Publishing
    Details
    ISBN: 9789264070028
    Language: English
    Pages: Online-Ressource (12 p.)
    Series Statement: OECD Guidelines for the Testing of Chemicals, Section 2
    Parallel Title: Parallelausg. Essai n 206; Oiseaux, essai de reproduction
    Parallel Title: Parallelausg. Essai n 206: Oiseaux, essai de reproduction
    Keywords: Environment
    Abstract: The purpose of this Test Guideline is to determine the effects on the reproduction of a substance administered with food to birds.Birds are fed a diet containing the test substance in various concentrations for a period of not less than 20 weeks. A minimum of three dietary concentrations of the test substance is required. The maximum recommended test concentration is 1000 ppm. Birds may be kept in pens as pairs (at least 12 pens per test group) or as groups of one male and two or three females (at least 8-12 pens per group). Birds are induced, by photoperiod manipulation, to lay eggs. Eggs are collected over a ten-week period, artificially incubated and hatched, and the young maintained for 14 days. Suitable facilities for rearing birds, preferably indoors, are necessary. Mortality of adults, egg production, cracked eggs, egg shell thickness (at least two eggs from each pen), viability, hatchability and effects on young birds are observed during the study.
    DOI: 10.1787/9789264070028-en
    URL: Volltext
    URL: lizenzpflichtig
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  • 4
    Online Resource
    Online Resource
    Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster (1984)
    Paris : OECD Publishing
    Details
    ISBN: 9789264071346
    Language: English
    Pages: Online-Ressource (6 p.)
    Series Statement: OECD Guidelines for the Testing of Chemicals, Section 4
    Parallel Title: Parallelausg. Essai n 477; Toxicologie génétique; Essai de mutation létale récessive liée au sexe chez Drosophila melanogaster
    Parallel Title: Parallelausg. Essai n 477: Toxicologie génétique: Essai de mutation létale récessive liée au sexe chez Drosophila melanogaster
    Keywords: Environment
    Abstract: Following the OECD Council decision, the Test Guideline 477 ‘Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster’ was deleted on 2nd April 2014.
    DOI: 10.1787/9789264071346-en
    URL: Volltext
    URL: lizenzpflichtig
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  • 5
    Online Resource
    Online Resource
    Test No. 207: Earthworm, Acute Toxicity Tests (1984)
    Paris : OECD Publishing
    Details
    ISBN: 9789264070042
    Language: English
    Pages: Online-Ressource (9 p.)
    Series Statement: OECD Guidelines for the Testing of Chemicals, Section 2
    Parallel Title: Parallelausg. Essai n 207; Ver de terre, essais de toxicité aigue͏̈
    Parallel Title: Parallelausg. Essai n 207: Ver de terre, essais de toxicité aigue͏̈
    Keywords: Environment
    Abstract: This Test Guideline includes two methods: a paper contact toxicity test and an artificial soil test. The recommended specie is Eisenia foetida (Michaelsen). The initial screening test (filter paper contact test) involves exposing earthworms to test substances on moist filter paper in order to identify potentially toxic chemicals to earthworms in soil. Five or more treatment levels in a geometric series and, at least, ten replicates (one worm per vial) for each treatment should be used. Tests are done in the dark and for a period of 48 hours. The artificial soil test gives toxicity data more representative of natural exposure of earthworms to chemicals. It involves keeping earthworms in samples of a precisely defined artificial soil. Five concentrations, in a geometric series, of the test substance have been applied. One concentration resulting in no mortality and one resulting in total mortality should be used. Four replicates for each treatment are recommended. Mortality is assessed 7 and 14 days after application.
    DOI: 10.1787/9789264070042-en
    URL: Volltext
    URL: lizenzpflichtig
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  • 6
    Online Resource
    Online Resource
    Test No. 204: Fish, Prolonged Toxicity Test: 14-Day Study (1984)
    Paris : OECD Publishing
    Details
    ISBN: 9789264069985
    Language: English
    Pages: Online-Ressource (9 p.)
    Series Statement: OECD Guidelines for the Testing of Chemicals, Section 2
    Parallel Title: Parallelausg. Essai n 204; Poisson, toxicité prolongée étude sur 14 jours
    Parallel Title: Parallelausg. Essai n 204: Poisson, toxicité prolongée étude sur 14 jours
    Keywords: Environment
    Abstract: Following the OECD Council decision, the Test Guideline 204 ‘Fish, Prolonged Toxicity Test: 14-Day Study’ was deleted on 2nd April 2014.
    DOI: 10.1787/9789264069985-en
    URL: Volltext
    URL: lizenzpflichtig
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