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  • English  (724)
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  • 2020-2024  (1,155)
  • 1995-1999  (31)
  • Medicine
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  • 1
    Language: English
    Pages: 2 volumes
    Series Statement: Classic reprint series
    Parallel Title: Nachdruck von Winterbottom, Thomas Masterman An account of the native Africans in the neighbourhood of Sierra Leone, to which is added an account of the present state of medicine among them
    Keywords: Medicine
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  • 2
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031594052
    Language: English
    Pages: 1 Online-Ressource(X, 95 p. 1 illus.)
    Edition: 1st ed. 2024.
    Series Statement: SpringerBriefs in Ethics
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Ethics. ; Genetics. ; Islam. ; Medicine ; Biology
    Abstract: This open access book offers unique insights into the key ethical issues faced by practitioners and discussed by ethicists in the field of genomics and incidental findings, with a focus on the Islamic moral tradition. Embark on an enlightening exploration of key ethical challenges in genomics and incidental findings, uniquely tailored to the context of the Muslim Arab world. Following the regional scientific leap in genomic infrastructure, this study provides a timely response to the need for a solid evidence base that pairs scientific research with cutting-edge research in Islamic ethics. A variety of expert perspectives have been incorporated, which produce a holistic overview of the intricate, interwoven systems, including the status quo of genomic research in the Gulf region, related Islamic ethical deliberations, and, finally, the governing jurisdictions and regulations on the ground. This publication stands as a pioneer work for academics interested in various fields, including genomics, bioethics, and Islamic studies. It equally serves as an invaluable guide for practitioners and policy-makers, equipping them to make informed decisions that resonate with the socio-cultural and religio-ethical nuances of the Islamic tradition. Being multidisciplinary in nature, the study is written in such a way that makes it accessible for those without a specialized background in Islamic studies or genomics.
    Note: Open Access
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  • 3
    Online Resource
    Online Resource
    Singapore : Springer Nature Singapore | Singapore : Imprint: Palgrave Macmillan
    ISBN: 9789819714711
    Language: English
    Pages: 1 Online-Ressource (VII, 155 p. 35 illus., 34 illus. in color.)
    Series Statement: Palgrave pivot
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Asia ; Medicine ; Biology ; Technological innovations. ; biotech ; pharmaceutical industry ; biopharmaceutical research ; sino-european trade ; innovation
    Abstract: Chapter 1: The Chinese healthcare and pharmaceutical market: Ignore at your own peril -- Chapter 2: China regulatory and legal reforms: Gateway to innovation and global integration -- Chapter 3: The golden age of the Chinese biopharma: Explosive growth in a thriving ecosystem -- Chapter 4: Innovation in the Chinese biopharma: From me-too to First-in-class -- Chapter 5: The art of the biopharma deal: The China angle -- Chapter 6: End if the first cycle. A drastic rest, future challenges and opportunities.
    Abstract: This book provides an insider’s overview of the emerging Chinese biopharma sector, its dynamics and trends, first bust and boom cycle, long-term perspectives, and how as a foreign company or investor to tap into this. China has gone from a country with no innovation in drug discovery, to a country which starts to out-license its biopharma technology to the rest of the world. The Chinese biopharma sector is only a decade old, but it already has become a new driver of growth and value. The book takes a closer look at what drives Chinese innovation in the biopharma sector, how to deal with this innovation, and what opportunities and challenges this provides for foreign companies. The book also takes a deep dive into its first biopharma boom and bust cycle, and what it means for the sector. It also explains what deals Chinese biopharma companies and investors are looking for, what works and what doesn’t, and how as a foreign company can tap into the world’s second largest healthcare market. Ben Wu has close to 30 years of experience in the pharmaceutical industry, holding senior executive positions in the Asia Pacific region for multinationals like J&J and Sanofi. He was active in several China originated biopharma companies, and is the founding CEO of Citrine Medicine, a venture capital backed biopharma. Originally from Belgium, Sven Agten has been living and working in China since 2004. He is a seasoned business executive working for SMEs and multinationals, with in-depth experience about business in China. He has published several books about China, all related to China business challenges, trends and opportunities.
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  • 4
    ISBN: 9783839471906 , 9783837671902
    Language: Undetermined
    Pages: 1 Online-Ressource (364 p.)
    Series Statement: Medical Humanities
    Keywords: Social, group or collective psychology ; Psychoanalytical theory (Freudian psychology) ; Medicine: general issues ; Biographie ; Erzählung ; Lebensgeschichte ; Wiedererzählung ; Interview ; Narratives Interview ; Identität ; Lebensgestaltung ; Medizin ; Therapie ; Krankheit ; Selbsterzählung ; Kultur ; Sprache ; Sozialpsychologie ; Psychoanalyse ; Kulturwissenschaft ; Biography ; Narrative ; Retelling ; Narrative Interview ; Identity ; Life Design ; Medicine ; Therapy ; Illness ; Culture ; Language ; Social Psychology ; Psychoanalysis ; Cultural Studies
    Abstract: Wie erzählen Menschen ihre Lebensgeschichten? Und wie verändern sich diese Erzählungen im Laufe der Zeit? Shevek K. Selbert widmet sich an der Schnittstelle von Biographieforschung, Psychologie und Erzählforschung vollumfänglich wiederholten biographisch-narrativen Interviews, die im Abstand von zehn Jahren geführt wurden. Als Pionierarbeit qualitativer Längsschnittforschung entwickelt er Methoden, um die Erzählversionen miteinander zu vergleichen - und bietet einen einzigartigen Einblick in die Dynamik sowie die (auch therapeutische) Bedeutung von Selbsterzählungen für die Identitätsbildung und die Lebensgestaltung
    Note: German
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  • 5
    ISBN: 9783031393556 , 9783031393549
    Language: Undetermined
    Pages: 1 Online-Ressource (810 p.)
    Series Statement: Health Informatics
    Keywords: Medical equipment and techniques ; Information technology: general topics ; Nursing and ancillary services ; Computer science ; Biology, life sciences ; Public health and preventive medicine ; Predictive analytics ; Artificial intelligence ; Medicine ; Machine learning ; Causal discovery ; Causal inference ; Genomics ; Medical knowledge discovery ; Clinical risk models ; Clinical risk stratification
    Abstract: This open access book provides a detailed review of the latest methods and applications of artificial intelligence (AI) and machine learning (ML) in medicine. With chapters focusing on enabling the reader to develop a thorough understanding of the key concepts in these subject areas along with a range of methods and resulting models that can be utilized to solve healthcare problems, the use of causal and predictive models are comprehensively discussed. Care is taken to systematically describe the concepts to facilitate the reader in developing a thorough conceptual understanding of how different methods and resulting models function and how these relate to their applicability to various issues in health care and medical sciences. Guidance is also given on how to avoid pitfalls that can be encountered on a day-to-day basis and stratify potential clinical risks. Artificial Intelligence and Machine Learning in Health Care and Medical Sciences: Best Practices and Pitfallsis a comprehensive guide to how AI and ML techniques can best be applied in health care. The emphasis placed on how to avoid a variety of pitfalls that can be encountered makes it an indispensable guide for all medical informatics professionals and physicians who utilize these methodologies on a day-to-day basis. Furthermore, this work will be of significant interest to health data scientists, administrators and to students in the health sciences seeking an up-to-date resource on the topic
    Note: English
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  • 6
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Palgrave Macmillan
    ISBN: 9783031388057
    Language: English
    Pages: 1 Online-Ressource(XV, 223 p. 3 illus.)
    Edition: 1st ed. 2024.
    Series Statement: Medicine and Biomedical Sciences in Modern History
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Imperialism. ; Medicine ; Science ; Europe ; History, Modern.
    Abstract: 1 Introduction: The Age of Empire, The Making of the Modern Nation and the Advancement of Medical Sciences; Mauro Capocci and Daniele Cozzoli- Part I. Tropical Medicine in the Evolution and the Collapse of Empires -- 2. Tropical Medicine and the “Consolidation” of the Portuguese Empire, 1902-1966; Isabel Amaral -- 3. Dutch Colonial Medicine and Empire-building in the Tropics: The Cases of Leprosy and Drug Use in the Dutch East and West Indies; Stephen Snelders -- Part II. Tropical Medical Institutions and Imperial Commercial and Political Expansion -- 4. The Business of Tropical Medicine: Connections between Anti-malarial Campaigns in Sierra Leone, 1899-1901, and Jamaica, 1908; Juanita De Barros -- 5. Leishmaniases in Brazil: A Historical Approach; Jaime Larry Benchimol -- Part III. Circulation of People, Objects and Ideas -- 6. Tropical Medicine, the Nation, and Colonial Expansion in the View of Italian Royal Navy Physicians at the End of the Nineteenth Century; Mauro Capocci and Daniele Cozzoli -- 7. From Universal Rats to Future Jungle Foci: Actors and Places of Plague in Brazil, 1899-1940s; Matheus Alves Duarte da Silva -- 8. Anti-fascist Medicine and the International Peace Campaign against Urban Raids in Spain and China, 1936-1939; Carles Brasó Broggi.
    Abstract: This book investigates the complex relationship between the development of modern empires, nation, and the history of tropical medicine. Broadening existing historiographical perspectives, it explores imperialism outside of the British Empire, drawing on case studies from other colonial experiences in Africa, Asia, and South America in the late-nineteenth and early-twentieth century. Each of these systems adopted different approaches to colonial health and medicine. By studying their diversity, it is possible to obtain a more comprehensive picture of what we now call ‘tropical medicine.’ The authors emphasise that the British model cannot be adapted to all colonial experiences, drawing on relevant cases from both interoceanic and continental empires. The collection comprises three sections. The first examines the role of tropical medicine in the evolution and collapse of empire in countries such as Portugal and the Netherlands. The second part analyses the links between tropical medical institutions and imperial commercial and political expansion in Britain and Brazil. Finally, the authors tackle the crucial interrelated circulation of people, objects, and ideas amongst countries including Brazil, China, Italy, and Spain. Using a medical lens to analyse the inter-connected processes of nation-building and colonial expansion in the late-nineteenth and early-twentieth centuries, this book provides valuable reading for scholars of imperialism and medical history alike.
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  • 7
    ISBN: 9783839467626
    Language: English
    Pages: 1 Online-Ressource, 278 Seiten , 1.31 Mbytes
    Edition: 1. Auflage
    Series Statement: Gesundheit, Kommunikation und Gesellschaft 5
    Series Statement: Gesundheit, Kommunikation und Gesellschaft
    Parallel Title: Erscheint auch als Hope and Uncertainty in Health and Medicine
    DDC: 610
    Keywords: (Produktform)Digital download ; (Produktform (spezifisch))PDF ; (Zielgruppe)Fachpublikum/ Wissenschaft ; (VLB-WN)9753 ; (DDC Deutsch 22)300 ; (DDC Deutsch 22)610 ; (BISAC Subject Heading)SOC002010 ; (BIC subject category)JHMC ; (BIC subject category)JFFH ; (BIC subject category)MBS ; Hope; Uncertainty; Emotion; Imagination; Health Care; Medical Practice; Medicine; Cultural Anthropology; Sociology of Medicine; Pharmacy; Public Health; ; Hope ; Uncertainty ; Emotion ; Imagination ; Health Care ; Medical Practice ; Medicine ; Cultural Anthropology ; Sociology of Medicine ; Pharmacy ; Public Health
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  • 8
    ISBN: 9783839466049 , 9783837666045
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Series Statement: Gesundheit, Kommunikation und Gesellschaft
    Keywords: Social work ; Medicine: general issues ; Soziale Arbeit ; Medizinische Rehabilitation ; Wirkung ; Gesundheit ; Pflege ; Reha ; Zusammenarbeit ; Teilhabe ; Körper ; Medizin ; Sozialarbeit ; Public Health ; Social Work ; Health-related Rehabilitation ; Effect ; Health ; Care ; Cooperation ; Participation ; Body ; Medicine
    Abstract: Soziale Arbeit ist ein wichtiger Teil der medizinischen Rehabilitation. Die Ausgestaltung ihrer Leistungen und ihre potentielle Wirkung blieben bislang allerdings unklar. An dieser Stelle setzen die Autor*innen an und präsentieren die Ergebnisse des Forschungsprojekts SWIMMER: Im Rahmen eines qualitativen Forschungsprojekts wurde die sozialarbeiterische Praxis von Sozialdiensten medizinischer Reha-Einrichtungen untersucht und ein Wirkmodell der Sozialen Arbeit in diesem Bereich entwickelt. Die vergleichende Darstellung der Resultate richtet sich sowohl an Sozialarbeiter*innen als auch an Verantwortliche in den Reha-Einrichtungen, die ihre eigene Praxis reflektieren und einen tieferen Einblick in gängige Arbeitsstrukturen der Sozialdienste erhalten wollen
    Note: German
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  • 9
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Palgrave Macmillan
    ISBN: 9783031128981
    Language: English
    Pages: 1 Online-Ressource(XIII, 296 p. 2 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Palgrave Studies in Medieval and Early Modern Medicine
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Science—History. ; Medicine—History. ; Europe—History—476-1492. ; Philosophy—History. ; Religion—History. ; Science ; Medicine ; Europe ; Philosophy ; Religion
    Abstract: 1. Introduction -- 2. Roger Bacon and the Unnatural State of Man -- 3. Learning to Prolong Life -- 4. The Corpus Equale -- 5. Medicines and their Effects on the Body -- 6. Debate and Authority in the Reshaping of Medicine -- 7. Franciscan Understanding of the Ideal Human Body -- 8. Conclusion.
    Abstract: This book examines Roger Bacon’s alchemical theories, and explains how he believed that the key to extending life lay not in the curricula as taught in the medical faculties of the universities, but in the study of alchemy. Though twelfth- and thirteenth-century alchemy was generally concerned with the transmutation of metals, Bacon’s alchemy was a much larger area of study, and encompassed the generation and corruption of all material things in the sublunary world. It was this aspect of alchemy, which Bacon referred to as speculative alchemy, that explained how the four elements of fire, air, water, and earth interacted with each other to make the basis of reality as man could know it. Thus, the study of alchemy in conjunction with humoral medicine could explain not only how the human body worked, but how it interacted with the materials around it, illuminating the method of prolonging life to extreme lengths. .
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  • 10
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Palgrave Macmillan
    ISBN: 9783030908355
    Language: English
    Pages: 1 Online-Ressource(XVII, 283 p.)
    Edition: 1st ed. 2023.
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Latin America—History. ; Medicine—History. ; Nursing. ; Social history. ; Labor. ; History. ; Latin America ; Medicine
    Abstract: 1. Background: The Struggle for Public Health and Equality -- 2. Nursing in Times of Socialism (1970–1973) -- 3. Nursing Under the Civilian-Military Cooperation (1973–1979) -- 4. Nursing in Times of State Reforms (1980–1982) -- 5. Nursing in Times of Transition and Distinction (1982–1990).
    Abstract: "A much-needed study that reveals the fundamental significance of the nursing profession in the history of public health and traces the important contributions nurses made to the creation of a functioning healthcare system. It explores vital questions of gender, medical practice, and power." —Jadwiga Pieper-Mooney, University of Arizona, USA "The authors convincingly demonstrate the links between nurses, past and present. This is an essential read for both studying processes of yesteryear and reviewing health policy of today." —Karina Ramacciotti, National University of Quilmes, Argentina This book offers the first in-depth account of healthcare policy in Chile across the twentieth century. It charts how nursing and nurses intersected with the political context of healthcare, with a focus on the country’s transition across welfare systems. Drawing on extensive archival research and interviews with nurses and governmental representatives, this book explores how the nursing profession implemented and challenged reform, while policies had an impact on nurses. It analyses nurses’ employment and mobility, and their lobbying through the press and through unions. The authors demonstrate that while Chilean health policy was influenced by US cultural politics, reform depended on the flexibility and willingness of nurses to carry through reforms. By examining the participation of the largest female professional group, the book offers new insights into the privatization of society on the pinnacle of industrial development and seeks to contribute to contemporary debates on Chile’s welfare system. It is a vital read for scholars researching the history of public health. Markus Thulin is based at the Brauweiler Memorial Site of the Rhineland Regional Council, Germany. He has been both a researcher of Latin American history at the University of Cologne and a history lecturer, with his interests revolving around women’s history, history of healthcare and history teaching. Ricardo A. Ayala is a sociologist with a background in history, healthcare and political science. He is a professor of ethics at Universidad de las Américas, Chile, and a research affiliate at Ghent University, Belgium.
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  • 11
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Palgrave Macmillan
    ISBN: 9783031271076
    Language: English
    Pages: 1 Online-Ressource(XIII, 276 p. 6 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Medicine and Biomedical Sciences in Modern History
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Great Britain—History. ; Science—History. ; Medicine—History. ; History, Modern. ; World politics. ; Social history. ; Great Britain ; Science ; Medicine
    Abstract: 1. Introduction -- 2. Alcohol and the Liver in Edwardian Britain -- 3. New Moderationism and the Liver in Interwar Britain -- 4. Cirrhosis as a Nutritional Disorder -- 5. Alcoholic Cirrhosis in the Late Twentieth Century -- 6. Conclusion.
    Abstract: The relationship between alcohol consumption and liver cirrhosis has long been contested by doctors and medical professionals, creating numerous implications for the public reputation of alcohol in Britain. Despite this, it was not until the 1970s that cirrhosis came to be understood as an ‘alcoholic disease’. This book contextualises developments in this debate through the twentieth century by examining the significant influence that medical expertise had on policy responses to alcohol misuse, as well as the social reputation of alcohol consumption. It demonstrates how the degree to which drinking was seen to be responsible for liver disease directly shaped how different groups, such as the temperance movement and the drinks industry, exaggerated or downplayed the destructive properties of alcohol. Covering a series of themes including the science of disease causation, the social standing of medical expertise, and alcohol and public health policy, this book argues that in order to properly understand the trajectory of debates around drinking we need to consider the twentieth-century ‘alcohol problem’ as primarily a medical issue. Contrary to the tendency by existing works to disassociate perceptions and responses to alcohol use from the objective knowledge of its effects on the body, this book shows that medical understandings of liver disease influenced how alcohol was conceptualised in relation to its harms. Offering a fresh perspective on the interaction between scientific knowledge and policy during the twentieth century, this book provides insights for those researching the social, political and cultural history of modern Britain, as well as historians of medicine and health. Ryosuke Yokoe is a JSPS Postdoctoral Fellow based in the Graduate School of Economics at the University of Tokyo, Japan. He is a historian of medicine and previously studied and taught at the University of Sheffield in the UK.
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  • 12
    Online Resource
    Online Resource
    Cham : Springer Nature Switzerland | Cham : Imprint: Palgrave Macmillan
    ISBN: 9783031386732
    Language: English
    Pages: 1 Online-Ressource(VIII, 356 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Medicine and Biomedical Sciences in Modern History
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Africa—History. ; Medicine—History. ; Africa, Sub-Saharan—History. ; Surgery. ; World politics. ; Technology. ; History. ; Africa ; Medicine ; Africa, Sub-Saharan
    Abstract: Chapter One: Introduction -- Part 1: The Face of War -- Chapter Two: Beginnings -- Chapter Three: The Making of a Surgeon -- Chapter Four: The Restoration of a Lost Soul: War -- Chapter Five: A Divine Right to Look Human: Brenthurst and Beyond -- Chapter Six: The Post-War Years: Going Solo -- Part 2: The Surgeon Ambassador -- Chapter Seven: The Heart of Darkness? Albert Schweitzer and Lambarene -- Chapter Eight: Fallen Blossoms: Hiroshima, Nagasaki, Nagashima and an Engagement with Modernity -- Chapter Nine: “The Brotherhood of Pain”: Israel -- Part 3: Utopia? -- Chapter Ten: “A Multitude of Differing Genes”: Intellect, Education and Equality -- Chapter Eleven: “He is My Younger Brother”: Nationalism, Independence and the Cold War -- Chapter Twelve: A Utopian Vision: Jack Penn’s Brave New World.
    Abstract: This book traces the career of pioneering South African plastic and reconstructive surgeon, Jack Penn, from its beginnings during the Second World War. It explores the establishment of Penn’s private practice, and his work in diverse countries, including Gabon, Japan and Israel, as he sought to rectify the injury caused by conflict. It also addresses his role on the President’s Council, established by Prime Minister P.W. Botha to introduce reform to the system of apartheid. Penn’s career is contextualised by modernisation which was a significant feature of twentieth-century South Africa. It was linked with race from the inception of the state in 1910 with racial segregation and paternalism. Penn’s work during the Second World War was part of a “modernist” bent by the state under Jan Smuts to take the lead in promoting science and technological development – which continued during apartheid. Modernisation was also fluid with state priority shifting between the two poles of development and security as apartheid policies were met with hostility both within the state and beyond its borders. Within the context of decolonisation, increasing black urbanisation required a balancing act on the part of the state to uphold the ideology of racial distinction while simultaneously addressing economic challenges – and this was reflected in the reform initiatives under Botha. Plastic and reconstructive surgery as evident in the work of Jack Penn is intertwined with this narrative of apartheid, modernisation and reform. It demonstrated Western prowess, with medicine and development a perceived bulwark against Communism. It also served as a means for the modernising apartheid state to initiate, maintain or enhance alliances with other states in the facing of mounting isolation and international condemnation. The career of Jack Penn, then, is a lens through which the contradictions, complexities and anxieties of twentieth-century South Africa are exposed. Suryakanthie Chetty is Senior Lecturer at Stellenbosch University, South Africa. She published her book, Africa Forms the Key: Alex Du Toit and the History of Continental Drift, with Palgrave in 2021.
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  • 13
    Online Resource
    Online Resource
    Cham : Springer Nature Switzerland | Cham : Imprint: Palgrave Macmillan
    ISBN: 9783031427428
    Language: English
    Pages: 1 Online-Ressource(XI, 329 p. 30 illus., 8 illus. in color.)
    Edition: 1st ed. 2023.
    Series Statement: Mental Health in Historical Perspective
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Science ; Medicine ; Psychology. ; Social sciences ; Imperialism. ; Great Britain
    Abstract: 1.Introduction -- 2. The Medical Certificate: A Technology of Inspection, Identification, and Expertise -- 3. Upon the Following Grounds: The Victorian System of Certification -- 4. Building Expert Certifiers: The Rise of Psychological Physicians -- 5. Facts of Insanity Around the World: Towards an Imperial History of Lunacy Certificates -- 6. A Choreography of Consensus: The Use of Hybrids Templates in Ontario -- 7. Epilogue. .
    Abstract: This book represents the first systematic study of the certification of lunacy in the British Empire. Considering a variety of legal, archival, and published sources, it traces the origins and dissemination of a peculiar method for determining mental unsoundness defined as the ‘Victorian system’. Shaped by the dynamics surrounding the clandestine committal of wealthy Londoners in private madhouses, this system featured three distinctive tenets: standardized forms, independent medical examinations, and written facts of insanity. Despite their complexity, Victorian certificates achieved a remarkable success. Not only did they survive in the UK for more than a century, but they also served as a model for the development of mental health laws around the world. By the start of the Second World War, more than seventy colonial and non-colonial jurisdictions adopted the Victorian formula for making lunacy official with some countries still relying on it to this very day. Using case studies from Europe, the Americas, and the Pacific, this book charts the temporal and geographical trajectory of an imperial technology used to determine a person’s destiny. Shifting the focus from metropolitan policies to colonial dynamics, and from macro developments to micro histories, it explores the perspectives of families, doctors, and public officials as they began to deal with the delicate business of certification. This book will be of interest to scholars working on mental health policy, the history of medicine, disability studies, and the British Empire. Filippo Maria Sposini is a researcher interested in the global history of madness, medicine, and law. He has published on the history of deviance in social sciences, the emergence of confinement procedures in Canada, and the production of psychiatric expertise in Victorian Britain. Previously, he studied at the University of Toronto in Canada and trained as a psychologist in Italy.
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  • 14
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031253157
    Language: English
    Pages: 1 Online-Ressource(XXII, 336 p. 2 illus.)
    Edition: 2nd ed. 2023.
    Series Statement: The International Library of Bioethics 103
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Medicine—Philosophy. ; Bioethics. ; Medicine
    Abstract: Chapter 1. Assisted Dying and the Proper Role of Patient Autonomy (Emma C. Bullock) -- Chapter 2. Preventing Assistance to Die: Assessing Indirect Paternalism Regarding Voluntary Active Euthanasia and Assisted Suicide (Thomas Schramme) -- Chapter 3. Autonomy, Interests, Justice and Active Medical Euthanasia (Julian Savulescu) -- Chapter 4. Mental Illness, Lack of Autonomy, and Physician-Assisted Death (Jukka Varelius) -- Chapter 5. Assisted Dying for Individuals with Dementia: Challenges for Translating Ethical Positions into Law (Jocelyn Downie) -- Chapter 6. Clinical Ethics Consultation and Physician Assisted Suicide (David M. Adams) -- Chapter 7. License to Kill: A New Model for Excusing Medically Assisted Dying? (Richard Huxtable) -- Chapter 8. Saving Lives with Assisted Suicide and Euthanasia: Organ Donation After Assisted Dying (David M. Shaw) -- Chapter 9. Everyday Attitudes About Euthanasia and the Slippery Slope Argument (Adam Feltz) -- Chapter 10. “You Got Me Into This...”: Procreative Responsibility and Its Implications for Suicide and Euthanasia (Rivka Weinberg) -- Chapter 11. Due Care in the Context of Euthanasia Requests by Persons with Psychiatric Illness: Lessons from a Recent Criminal Trial in Belgium (Marc De Hert) -- Chapter 12. Medical Futility and Assisted Dying (Nancy S. Jecker) -- Chapter 13. Medical Aid in Dying: The Case of Disability (Christopher A. Riddle) -- Chapter 14. A Feminist Approach to Medical Aid in Dying: Identifying a Path Forward (Jennifer A. Parks) -- Chapter 15. Envisioning Markets in Assisted Dying (Michael Cholbi) -- Chapter 16. Robots, AI, and Assisted Dying: Ethical and Philosophical Considerations (Ryan Tonkens) -- Chapter 17. Dying to Live: Transhumanism, Cryonics, and Euthanasia (Adam Buben) -- Chapter 18. When is Self-perceived Burden an Acceptable Reason to Hasten Death? (Michael Gill).
    Abstract: This book provides novel perspectives on ethical justifiability of assisted dying in the revised edition of New Directions in the Ethics of Assisted Suicide and Euthanasia. Going significantly beyond traditional debates about the value of human life, the ethical significance of individual autonomy, the compatibility of assisted dying with the ethical obligations of medical professionals, and questions surrounding intention and causation, this book promises to shift the terrain of the ethical debates about assisted dying. The novel themes discussed in the revised edition include the role of markets, disability, gender, artificial intelligence, medical futility, race, and transhumanism. Ideal for advanced courses in bioethics and healthcare ethics, the book illustrates how social and technological developments will shape debates about assisted dying in the years to come.
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  • 15
    Online Resource
    Online Resource
    Wiesbaden : Springer Fachmedien Wiesbaden | Wiesbaden : Imprint: Springer
    ISBN: 9783658394981
    Language: English
    Pages: 1 Online-Ressource(XIV, 45 p. 214 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Springer essentials
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Medicine—History. ; Ethics. ; Medical Ethics. ; Social medicine. ; Internal medicine. ; Medicine
    Abstract: Senicide in history and ethnography -- The meaning of senicide today -- Forms of senicide -- On the ethics of dealing with senicide.
    Abstract: Raimund Pousset gives in this essential a concise account of senicide, the modern form of cultural killing of the elderly. He sheds light on both the history and the current situation of an ancient method. Practiced for millennia almost everywhere in the world, this custom of actively disposing of old 'useless' people or passively putting oneself to death is increasingly being revived today. Senicide is a nameless and silent scandal in our modern, enlightened society. The author wishes to bring this silent death into the focus of a mindful professional public, for the segregation of old age and the avalanche of costs in health care suggest that senicide will continue to grow in sad significance. The content - Senicide in history and ethnography - The meaning of senicide today - Forms of senicide - On the ethics of dealing with senicide The target groups - Lecturers and students of gerontology, palliative medicine, psychology, sociology, theology, philosophy, ethnology, history, jurisprudence and cultural studies - Doctors, nurses, hospice and euthanasia workers, clergy, social workers, educators and ethicists. The author Raimund Pousset, a qualified educationalist with additional training in supervision and psychotherapy, taught supervision as a senior lecturer at a technical college for organisation and management as well as gerontology and education at a technical college for social education and in geriatric care. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
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  • 16
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031191046
    Language: English
    Pages: 1 Online-Ressource(XI, 262 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Philosophy and Medicine 145
    Parallel Title: Erscheint auch als Chasing Tourette's
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    RVK:
    Keywords: Medicine—Philosophy. ; Social sciences. ; Humanities. ; Psychology, Pathological. ; Medicine
    Abstract: Chapter 1. Introduction -- Chapter 2. Clock Time and Tic Nosology -- Chapter 3. Volition in the Ticcing Brain -- Chapter 4. Freedom in a Tourettic World -- Chapter 5. Agency and Ownership in Tic Disorders -- Chapter 6. Tics as Intentional Actions: A Revised Taxonomy -- Chapter 7. On Reflexes and Stimuli: Tics as Nonactions -- Chapter 8. ‘No ill will’: Ticcing on Moral Grounds -- Chapter 9. Conclusion: Beyond Causes and Cures.
    Abstract: This book offers a philosophical perspective on contemporary Tourette Syndrome scholarship, a field which has exploded over the last thirty years. Despite intense research efforts on this common neurodevelopmental condition in the age of the brain sciences, the syndrome’s causes and potential cures remain intriguingly elusive. How does this lack of progress relate to the tacitly operating philosophical concepts that shape our current thinking about Tourette Syndrome? This book foregrounds these tacit concepts and shows how they relate to “big topics” in philosophy such as time, volition, and the self. By tracing how these topics relate to current research on Tourette’s, it invites us to re-think our approach to research and care. Such re-thinking is urgently needed: individuals and families living with Tourette Syndrome remain under-serviced as pharmacological and behavioural therapies provide relief for some but not all who need support. This book highlights what questions we ask and do not ask in contemporary scholarship, thereby surfacing invisible constraints and opportunities in the field. It is of interest to scholars, health professionals, students, and affected families who want to better understand this burgeoning field of research with its conceptual controversies, approaches to aetiology, and directions for new research and improved clinical care.
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  • 17
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031279454
    Language: English
    Pages: 1 Online-Ressource(XVI, 218 p. 51 illus., 44 illus. in color.)
    Edition: 1st ed. 2023.
    Series Statement: Integrated Science 16
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Biology—Philosophy. ; Medicine—Philosophy. ; Science—Social aspects. ; Bioethics. ; Medicine and the humanities. ; Biology ; Medicine ; Science
    Abstract: Chapter 1 A New Way of Coming-To-Be -- Chapter 2 Biodigital Being(s): Praxis Body Futures -- Chapter 3 Avatar Therapy and Clinical Care in Psychiatry: Underlying Assumptions, Epistemic Challenges, and Ethical Issues -- Chapter 4 Humanity’s In-Betweenness: Towards a Prehistory of Cyborg Life -- Chapter 5 “The Universe of the Person is the Universe of Man?”: Expanding the Schelerian Concepts of Philosophical Anthropology and Personhood into the 21st Century -- Chapter 6 Posthumanizing Relaxation in Science-Fiction ASMR -- Chapter 7 Human and Non-Human Persons in Not Inhuman Civilization -- Chapter 8 The eXtended Uni/Meta/Verse (XV) and the Liminal Spacesof Body, Ownership, and Control -- Chapter 9 Sophia: Potentials and Challenges of a Modern Cyborg -- Chapter 10 From Natural Humans to Artificial Humans and Back Again: An Integrative Neuroscience-AI Perspective on Confluence -- Chapter 11 The Transhuman Unbounded Existence: AI, Nanorobots, and Computational Simulation.
    Abstract: This volume discusses the definitional problems and conceptual strategies involved in defining the human. By crossing the boundaries of disciplines and themes, it offers a transdisciplinary platform for exploring the new ideas of the human and adjusting to the dynamic in which we are plunged. The emerging cyborgs and transhumans call for an urgent reconsideration of humans as individuals and collectives. The identity of the human in the 21st century eludes definitions underpinned by simplifying and simplified dichotomies. Affecting all the spheres of life, the discoveries and achievements of recent decades have challenged the bipolar categorizations of human/nonhuman and human/machine, real/virtual and thus opened the door to transdisciplinary considerations. Ours is a new world where the boundaries of normality and abnormality, a legacy of the long history of philosophy, medicine, and science need dismantling. We are now on our way to re-examine, re-understand, and re-describe what normal-abnormal, human-nonhuman, and I-we-they mean. We find ourselves facing what resembles the liminal stage of a global ritual, a stage of being in-between—between the old anthropocentric order and a new position of blurred boundaries. The volume addresses philosophical, bioethical, sociological, and cognitive approaches developed to transcend the binaries of human-nonhuman, natural-artificial, individual-collective, and real-virtual. .
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  • 18
    Online Resource
    Online Resource
    Cham : Springer Nature Switzerland | Cham : Imprint: Springer
    ISBN: 9783031292392
    Language: English
    Pages: 1 Online-Ressource(IX, 296 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Philosophy and Medicine 133
    Parallel Title: Erscheint auch als Incentives and Disincentives in Organ Donation
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    RVK:
    Keywords: Medicine—Philosophy. ; Ethics. ; Medicine
    Abstract: Part 1. Introduction -- Chapter 1. Towards a New Model of Incentives for Organ Donation (Ruiping Fan) -- Part 2. Beijing papers -- Chapter 2. The Background of Organ Donation in Mainland China (Guangkuan Xie) -- Chapter 3. Mixed Incentives, Different Voices: A Qualitative Study of Organ Donation Incentive Policies in Two Big Chinese Cities (Jian Tang) -- Chapter 4. Organ Donation Incentives in Mainland China: Ethical Commentaries and Reform Recommendations (Jian Tang) -- Part 3. Chicago papers -- Chapter 5. The Concepts and Development of Organ Donation Policy in the United States (Wan-Zi Lu) -- Chapter 6. Interviews in Chicago (Wan-Zi Lu) -- Chapter 7. Ethical Considerations about Three Incentive Models based on Research in Chicago (Wan-Zi Lu) -- Part 4. Tehran papers -- Chapter 8. The Kidney Transplantation Program in Iran (Mitra Mahdavi-Mazdeh) -- Chapter 9. Interview Findings of the Organ Donation in Iran (Mitra Mahdavi-Mazdeh) -- Chapter 10. A Comment on the Barriers and Incentives of Organ Donation in Iran (Mitra Mahdavi-Mazdeh) -- Part 5. Hong Kong papers -- Chapter 11. Organ Donation: The Hong Kong Context (Ho Mun Chan) -- Chapter 12. Incentives for Organ Donation in Hong Kong: In-depth Interviews (T-fai Yeung) -- Chapter 13. Incentives for Organ Donation in Hong Kong: A Survey (Yang Zheng) -- Chapter 14. Organ Donation, Comprehensively Good Incentives, and the Family: A Comment on Hong Kong’s Interview Findings and Survey Results (Ruiping Fan) -- Part 6. Implications for Hong Kong and other societies: Towards a New Model -- Chapter 15. Organ Donation Incentives: A Multicultural Comparison (Lisa M. Rasmussen) -- Chapter 16. Organ Donation Incentives: Implications for Hong Kong and Beyond (Chunyan Ding).
    Abstract: This book provides the first systematic study on three types of incentives for organ donation. It covers extensive research conducted in four culturally different societies: Hong Kong, mainland China, Iran and the United States, and shows on the basis of the research that a new model of incentives can be constructed to enhance organ donation in contemporary societies. The book focuses on three types of incentives: honorary incentives, commonly adopted in the United States and other Western countries by offering things such as a thank-you card and a memorial park for donors to encourage donations motivated by pure altruism; compensationalist incentives, adopted in the Islamic Republic of Iran to encourage donation by providing monetary compensation to unrelated living donors for appreciating their altruistic contribution of donation; and familist incentives, implemented in Israel and mainland China to provide priority to organ transplantation to donors and/or their family members. The book demonstrates that a new model of incentives must go beyond offering only one type of incentives and should rather include different types of incentives that are practically effective, politically legitimate and ethically justifiable for particular societies. This implies that suitable incentive measures may vary from society to society to optimize organ donation. This book provides a clear reference for both the scholars and practitioners in the field of organ transplantation, as well as for general readers interested in bioethics and health care policy.
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  • 19
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031312717
    Language: English
    Pages: 1 Online-Ressource(XXI, 375 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: History, Philosophy and Theory of the Life Sciences 32
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Biology—Philosophy. ; Technology—Philosophy. ; Medicine—Philosophy. ; Biology ; Technology ; Medicine
    Abstract: Introduction to the English version* -- Original introduction -- PART 1 - CONCEPTUAL AND HISTORICAL PROBLEMS. Section 1. Origins of functional discourse in the life sciences Chapter 1 - Biological Function: A Brief Slice of History (James G. Lennox) -- Chapter 2 - The Structure-Function Relationship in the Advent of Biology (François Duchesneau) -- Chapter 3 - Tissues, Properties, Functions: The Term Function in French Biology in the Early 19th Century (Laurent Clauzade) -- Chapter 4 - « Design », History of the Word and the Concept: Natural Sciences, History, Theology, Aesthetics (Daniel Becquemont) -- Chapter 5 - Function and Purpose: Review of the “Written Symposium” (1976-1984) Organized by the Institut de la Méthode of the Ferdinand Gonseth Association (Pierre-Marie Pouget) * -- Section 2. Function, selection, adaptation Chapter 6 - How are Traits Typed for the Purpose of Ascribing Functions to Them? (Karen Neander) -- Chapter 7 - Attribution of Functions and Levels of Organization in Biology (Jean Gayon) -- Chapter 8 - Function and Adaptation: A Conceptual Demarcation, Instigated by Borderline Cases for Etiological Theory (Philippe Huneman) -- Chapter 9 - Function, Adaptation, and Design in Biology (Gustavo Caponi)* -- Chapter 10 - Ecological Functions, External Teleology and Between-Species Beneficial Relations (or How Aristotle and Kant Can Help us Understand Functions in Ecology) (Antoine C. Dussault)* -- PART 2 - FUNCTIONS IN BIOLOGY. Section 3. Structures and functions in morphology and paleontology Chapter 11 - The Problem of Complex Causality at the Origin of the Structure-Function Relationship 1/ Generality, 2/ The Case Of Bone Tissue (Armand de Ricqlès and Jorge Cubo) -- Chapter 12 - Structure, Function and Evolution of the Middle Ear of Extant and Extinct Vertebrates: Paleobiological and Phylogenetic Interpretations (Michel Laurin) -- Section 4. Attributions of function in experimental biology Chapter 13 - The History of Integration: From Spencer to Sherrington and Later (Jean-Claude Dupont) -- Chapter 14 - Assigning Functions to Individual Macromolecules: A Complex History that Reflects the Transformations of Biology (Michel Morange) -- Chapter 15 - Function, Functioning, Multifunctionality: Genetics of Development and Evolution (Charles Galperin) -- Chapter 16 - Does the Immune System have a Function? (Thomas Pradeu) -- Section 5: Functions and the Origins of Life Chapter 17 - Functions in Chemistry (Aurore Dupin)* -- Chapter 18 - Heterotrophy vs. Autotrophy: Carbon Metabolism in the Debate on the Origins of Life in the Middle of the 20th Century (Stéphane Tirard) -- Chapter 19 - What are Ribozymes for? Arguing for Function Pluralism (Christophe Malaterre) -- Section 6. Functions in Psychology and Neuroscience Chapter 20 - Functionalist Psychologists From the School of Chicago and the Beginnings of Behaviorism (Françoise Parot) -- Chapter 21 - Face Recognition and Functional Analysis (Denis Forest) -- PART 3 - FUNCTION AND DYSFUNCTION IN MEDICINE AND IN TECHNOLOGY. Section 7. Function and Malfunction Chapter 22 - Dys-, Mal- and Non-: the Other Side of Functionality (Ulrich Krohs) -- Chapter 23 - Functional Reasoning in Psychiatry (Arnaud Plagnol) -- Section 8. The Same Functional Reasoning in Engineering and Biology? Chapter 24 - The Idea of Function in Biology and Robotics as Reflected in the “RoboCoq” Project (Anick Abourachid and Vincent Hugel) -- Chapter 25 - Theories of Technical Functions: Sophisticated Combinations of Three Archetypes (Wybo Houkes and Pieter E. Vermaas) -- Chapter 26 - What a Functional Explanation Explains: the Case of Bio-Artifacts (Françoise Longy) -- Chapter 27 - Technical Function, Use and Functioning in Simondon’s Ontogenetic Thought (Jean-Hugues Barthélémy)*.
    Abstract: This book, originally published in French, examines the philosophical debates on functions over the last forty years and proposes new ways of analysis. Pervasive throughout the life sciences, the concept of function has the air of an epistemological scandal: ascribing a function to a biological structure or process amounts to suggesting that it is explained by its effects. This book confronts the debates on function with the use of the notion in a wide range of disciplines, such as biology, psychology, and medicine. It also raises the question of whether this notion, which is as old in the history of technology as it is in the life sciences, has the same meaning in these two domains.
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  • 20
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031294365
    Language: English
    Pages: 1 Online-Ressource(XVI, 227 p. 219 illus.)
    Edition: 1st ed. 2023.
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als Buick, Adam Intellectual property rights in pharmaceutical test data
    RVK:
    Keywords: Information technology—Law and legislation. ; Mass media—Law and legislation. ; Medicine—Research. ; Biology—Research. ; Medical laws and legislation. ; Mass media ; Information technology ; Medicine ; Biology
    Abstract: Chapter 1 – Introduction -- Chapter 2 – An overview of the protection of submitted test data -- Chapter 3 – The origins of test data exclusivity -- Chapter 4 – The protection of submitted test data and the TRIPS Agreement -- Chapter 5 – The globalisation of test data exclusivity -- Chapter 6 – Approaches to the Implementation of the Protection of Submitted Test Data -- Chapter 7 – The impact of test data exclusivity -- Chapter 8 – The Impact of Test Data Exclusivity on Measures for the Protection of Public Health -- Chapter 9 – Conclusion.
    Abstract: This book considers the intellectual property protection of clinical test data that has been submitted to governments, in particular through test data exclusivity rights. It focuses on how these intellectual property rights first emerged in the early 1980s, how they have globalised over the past four decades, and what impact they have had upon access to medicine. This book makes a number of significant and original contributions to the literature around the protection of submitted test data. First, the book draws upon the theory of regulatory globalisation to provide an explanation of how intellectual property rights in submitted pharmaceutical test data have become nearly ubiquitous in the legal systems of most major economies. Second, through a comprehensive analysis and synthesis of provisions on the protection of submitted test data in free trade agreements, as well as a comparison of a range of national approaches to the protection of submitted test data, it reveals the broader global regulatory pattern that has given rise to these intellectual property rights. Third, by analysing data on drug approvals in the US, it provides an empirical insight into the impact of test data exclusivity in national pharmaceutical markets. Fourth, the book covers a number of developments regarding test data exclusivity that have occurred as a result of responses to the COVID-19 pandemic, both at the national level as well as at the World Trade Organisation (WTO). This book will appeal to academics researching the intersection of intellectual property and the life sciences, civil society activists working to promote access to medicines, and students (particularly those at the post-graduate level) studying the relationship between intellectual property and medicine.
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  • 21
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031418242
    Language: English
    Pages: 1 Online-Ressource(XI, 210 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Philosophy and Medicine 148
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Medicine ; Environmental health. ; Sociology.
    Abstract: Part 1. Critical history and critical phenomenology of Health and Well-being -- Chapter 1. Global Health and the Collateral Damage Utilitarianism (Kelly Oliver) -- Chapter 2. Why does mental illness exist? Considerations on anthropological vulnerability (Thomas Fuchs) -- Part 2. Well-Being, Health and Embodiment -- Chapter 3. The Ontological and Ethical Value of Vulnerability (Valeria Bizzari) -- Chapter 4. Well-Being, Health, and Human Embodiment: The Familial Lifeworld (Mark J. Cherry) -- Part 3. Well-Being, Health and the Environment -- Chapter 5. Being and Aging: A Phenomenology of Time, Place and Illness (Marjolein Oele) -- Chapter 6. Vulnerability, Mutual Aid, Empathy (Gerard Kuperus) -- Part 4. The Vulnerability of the Human World and Responsibility -- Chapter 7. Pandemic Discrimination and Responsibility for Culturally Vulnerable Groups. A Phenomenological and Bioethical Perspective (Geoffrey Dierckxsens) -- Chapter 8. Interdependency, responsibility and the care for the living (Elodie Boublil) -- Part 5. The vulnerability of the human world. Health, technology and the environment -- Chapter 9. From digital medicine to embodied care (Francesca Brencio) -- Chapter 10. Aiming at Well-Being with Brain Implants: Any risk of Implanting Unprecedented Vulnerabilities? (Frederic Gilbert) -- Chapter 11. Phenomenology of algorithms and emotions in cases of early re-hospitalization (Susi Ferrarello) -- Chapter 12. Conclusion.
    Abstract: This book contains the most recent papers problematizing the notions of health, vulnerability, and well-being for individuals and their environment. Organized in 5 sections the book takes into consideration the critical and phenomenological history of well-being and health, their technological manipulation, how these notions connect with the body and the specific vulnerability of the human being, and what responsible direction we can take to improve people's relation to themselves, to other living beings and their environment. In order to address the issue of the vulnerability of the human world and how to respond to its specific challenges, the contributions in this book discuss the topic from a broad range of perspectives, including anthropological, psychological, sociological, philosophical, and environmental.
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  • 22
    Online Resource
    Online Resource
    Cham : Springer Nature Switzerland | Cham : Imprint: Springer
    ISBN: 9783031457661
    Language: English
    Pages: 1 Online-Ressource(XIV, 188 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: Ethics of Science and Technology Assessment 53
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Medicine ; Medical Ethics. ; Knowledge, Theory of.
    Abstract: Introduction -- Finding Value in Concepts -- Meaning as Definition and Meaning as Use -- Locating the Conceptual Change in Scientific Research -- The Concept of Disease in the Traditional Debates -- Evolution and Evolutionary Medicine in Disease -- New Developments in Evolutionary Theory and Evolutionary Medicine, New Frontiers for Evolutionary Medicine -- Conclusion.
    Abstract: This book analyses the concept of disease, as defined in the context of evolutionary medicine. Upon introducing the reader to evolutionary medicine in its current form and describing its approach to disease instances, the book leverages thoughts and instruments of knowledge of epistemology, social sciences, and ethics to answer the question: “How can we build a timely and appropriate concept of disease?” At first, it looks at the social concerns of medicalization, for example focusing on the suffering of people who have not been diagnosed, or whose suffering is not caused by certain elements that falls under the definitions of disease. In turn, it merges different, both conceptual and empirical considerations in one comprehensive analysis, with the aim of fostering a multidisciplinary understanding of the phenomenon of disease. This book also highlights certain kinds of epistemic injustices that are taking place in the healthcare system, as this is currently conceived in post-industrial societies, thus offering a timely contribution to the current debate around social justice in healthcare.
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  • 23
    ISBN: 9783031429446
    Language: English
    Pages: 1 Online-Ressource(XV, 650 p. 1 illus.)
    Edition: 1st ed. 2023.
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Medical laws and legislation. ; Medicine ; Biology ; Information technology ; Mass media ; Data protection.
    Abstract: Introduction -- Medical research and data protection in Europe. The emergence of general legal principles -- Part I Syllabus of the burning questions -- Anonymisation (Part I) ‘What is the state-of-the-art of anonymisation in data-driven health research and its role in the “European Health Data Space Regulation”?’ -- Anonymisation - The trap for biobanking (Part II) ‘Why the anonymisation could be a trap for the biobanking activity? Can there really be anonymisation in the research biobanks?’ -- Applying national law in cross-border research activity ‘Which national law should be applied in cross-border research activity in the local implementation of GDPR?’ -- Archived tissue ‘What is the potential use for research under GDPR for archived tissue specimens obtained in a diagnostic or therapeutic pattern?’ -- Blockchain and dynamic consent ‘Can the blockchain realise proper support for dynamic consent?’ -- Brexit effects ‘What are the “Brexit effects” on the exchange of data and biological samples with the UK?’ -- Broad consent ‘Do patients have to be informed about the concrete research projects for which their data and biosamples are to be used? Is so-called broad consent adequate?’ -- Cloud ‘How is it possible to exchange research and personal data using the cloud without being a danger to patients?’ -- Consent requirements ‘What are the terms and conditions of informed consent?’ -- Consent and assent by children ‘Management of assent and consent by children. What should be done when they reach the appropriate age: Obligations and recommendations?’ -- Consent & Technology ‘Is dynamic consent the solution or can an interactive website solve the problem of consent?’ -- Consent from children and vulnerable people ‘What protection is provided to people who are not able to give consent or are restricted in their ability to give consent, for example, children or people with disabilities?’ -- Consent withdrawal ‘What is the procedure if consent will later be withdrawn?’ -- Covid-19 ‘Are the rules of the GDPR on scientific research - if correctly applied - able to guarantee personal health data in the context of Covid-19 research activities?’ -- Dynamic consent ‘According to sentence three of recital 33, persons whose data are to be stored for future research projects should be given the opportunity to provide their consent to only certain areas of research or parts of research projects to the extent permitted by the purpose pursued. How can this be realised?’ -- Ethics committees ‘To what extent are ethics committees relevant for the activities of the biobank?’ -- Ethic & Biobanks ‘What are the steps needed to implement bioethical issues in a population-based and disease-based biobank?’ -- Ethical principles and legal provisions ‘What ethical principles apply to biobanking activities?’ -- EU legislation and health data protection ‘For the processing of medical personal data in biobanking activities, is the GDPR the sole reference legislation in the EU?’ -- Forensic databases (Part I) ‘Forensic use of research biobanks: How does the GDPR regulate the issue?’ -- Forensic databases (Part II) ‘How does EU law address issues concerning access for forensic purposes to research biobanks?’ -- Future research ‘How to deal with the problem that future research may often not be able to be defined in narrow and specific terms, as it depends on the current state of research?’ -- Genetic data ‘What are the ethical–legal consequences entailed in the exceptional nature of genetic information?’ -- Granularity ‘When processing personal data and biological material in research activities, is it possible to derogate from the general rules and, in particular, from the rule of granularity of consent?’ -- Imaging biobank ‘What are the areas of the GDPR bearing on an image biobank?’ -- Industry perspective ‘Contracting in the light of the GDPR: What are the key considerations for transfers of biosamples and data from an industry perspective?’ -- Joint controller agreement ‘What is the function of the joint controller agreement in sharing personal data with a large research consortium or biobank infrastructures?’ -- Legitimate interests ‘Are legitimate interests lawful grounds for processing retrospective health data and tumour tissue?’ -- Ownership of human biological material ‘To whom does the “ownership” of the human body and its parts belong? Who has the right to dispose of it and for what purpose?’ -- Paediatric biobanks (general overview) ‘How to tackle the protection of personal data and other ethical issues in a paediatric biobank? -- Public Interest Who decides on the existence of a public interest?’ -- Rare diseases and data protection (Part I) ‘How to enable research on rare diseases while protecting personal data?’ -- Rare diseases and legal, ethical, technical and societal needs (Part II) ‘Why are biobanks and research networks able to support data protection issues in rare disease research?’ -- Rare paediatric diseases ‘Does the GDPR support dynamic consent/assent strategies for rare paediatric diseases?’ -- Residual material ‘What applies to the processing of residual material with its associated data? Is explicit consent required for this?’ -- Retention time - conservation of personal data (Part I) ‘How long can personal data be stored in a biobank?’ -- Retention time - conservation of tissues (Part II) ‘How long can tissues be stored in a biobank?’ -- Retrospective research ‘Is the use of broad consent for retrospective research on data and tissue possible in the framework of GDPR?’ -- Scientific research and the biomedical sector. Requirements and methods for planning and managing a “data protection by design” project. ‘How can a scientific research project be planned and managed to comply “by design” with GDPR?’ -- Secondary use (Part I) ‘What does secondary use mean for research using tissue specimens obtained in a diagnostic or therapeutic setting, in the light of the GDPR?’ -- Secondary use and dual use of biomaterial samples (Part II) ‘Does broad consent include the reuse and dual use of biomaterial samples and their associated personal data?’ -- Transfer of the personal data for research purposes towards non-EU countries ‘How is it possible to transfer personal data for research purposes to non-EU countries? -- Users ‘Who are the users in the context of biobanks? What are the factors to consider when dealing with the human component?’ -- Part II Biobanking legal and ethical requirements across Europe: National reports (in alphabetic order) -- Instead of a preface Towards regulation for the European health data research: A comparative analysis -- National report: Austria -- National report: Belgium -- National report: Bulgaria -- National report: Croatia -- National report: Cyprus -- National report: Czech Republic -- National report: Denmark -- National report: Estonia -- National report: Finland -- National report: France -- National report: Germany -- National report: Greece -- National report: Hungary -- National report: Ireland -- National report: Italy -- National report: Latvia -- National report: Lithuania -- National report: Luxemburg -- National report: Malta -- National report: Netherlands -- National report: Poland -- National report: Portugal -- National report: Romania -- National report: Slovakia -- National report: Slovenia -- National report: Spain -- National report: Sweden -- National report: United Kingdom -- Conclusion.
    Abstract: The book deals with the effective operation of the rules related to biomedical research and pays attention to the activities of the national legislatures of the 27 Member States in the field of scientific research. This multilevel system has an impact on biobanking activity. The book answers questions realized by operators on the main biobanks around the EU in the field of GDPR. The authors and editors used the questions born from brainstorming among members of the Association European, Middle East & Africa for Biopreservation and Biobanking (ESBB) to offer to the operators in biobanking activity and researchers quickly answer to their daily questions, but with authors highest quality. Further the book provides a comprehensive review of the rapidly expanding field of biobanking. It provides researchers and scholars working on biobanking and bio-sharing and more in general in the university hospitals and clinical trial consortiums, and companies, biomedical researchers, but also jurists and the professionals (in particular judges, lawyers, officers) an instrument rigorous but easy to use of the GDPR in the case of biobanking activities. The book identifies a methodological path to tackle the legal or ethical problem on a specific scientific-technological to verify existing solutions and give ideas for future applications. The importance of the legal solution influences the implementation of the development of the biobanking activity service itself.
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  • 24
    Online Resource
    Online Resource
    Montreal : McGill-Queen’s University Press (mqup)
    ISBN: 9780228017523 , 9780228017530 , 9780228017905 , 9780228018605
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Series Statement: Intoxicating Histories
    Parallel Title: Erscheint auch als Bhattacharya, Nandini Disparate remedies
    Keywords: 1870-1960 ; Pharmaindustrie ; Arzneimittelmarkt ; Pharmahandel ; Arzneimittel ; Traditionelle Medizin ; Kolonialismus ; Indien ; Medicine
    Abstract: At present India is a leading producer, distributor, and consumer of generic medicines globally. Disparate Remedies traces the genealogy of this development and examines the public cultures of medicine in the country between 1870 and 1960. The book begins by discussing the expansion of medical consumerism in late nineteenth-century India when British-owned firms extended their sales into remote towns. As a result, laboratory-produced drugs competed with traditional remedies through side-by-side production of Western and Indian drugs by pharmaceutical companies. The emergent middle classes, the creation of a public sphere, and nationalist politics transformed the medical culture of modern India and generated conflict between Western and Indigenous medical systems and their practitioners. Nandini Bhattacharya demonstrates that these disparate therapies were sustained through the tropes of purity or adulteration, potency or lack of it, and epistemic heritage, even when their material configuration often differed little. Uniquely engaging with the cultures of both consumption and production in the country, Disparate Remedies follows the evolution of medicine in colonial India as it confronted Indian modernity and changing public attitudes surrounding health and drugs
    Note: English
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  • 25
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    ISBN: 9783031126048
    Language: English
    Pages: 1 Online-Ressource(VIII, 269 p. 1 illus.)
    Edition: 1st ed. 2023.
    Series Statement: History, Philosophy and Theory of the Life Sciences 29
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Parallel Title: Erscheint auch als
    Keywords: Biology—Philosophy. ; Medicine—History. ; Life sciences. ; Biology ; Medicine
    Abstract: 1. Brooke Holmes (Princeton): The Two-Soul Problem: Aristotle, the Stoics, Galen -- 2. Hannah Landecker: Metabolic Materialism -- 3. Christopher Donohue (NIH): “Concerning the Tenacious Adherence of Animal Spirit to Matter" -- 4. Crystal Hall (Bowdoin College) and Erik L. Peterson (University of Alabama): Who were the vitalists and where did they go? -- 5. Jane Maienschein (ASU): Early Twentieth Century Accounts of the Individuality of Organized Whole Organisms -- 6. Bohang Chen (Ghent): Hans Driesch and vitalism: the standpoint of logical empiricism -- 7. Mazviita Chirimuuta (Pittsburgh): The Critical Difference between Holism and Vitalism in Cassirer’s Philosophy of Science -- 8. Tano S. Posteraro (Penn State): Vitalism and the Problem of Individuation: Another Look at Bergson’s Élan Vital -- 9. Sebastjan Vörös (Ljubljana): Is there not a truth of vitalism? Transcendental vitalism in light of Goldstein, Merleau-Ponty, and Varela -- 10. Arantza Exteberria (IAS, San Sebastian) and Charles T. Wolfe (Ghent): Canguilhem and the logic of life -- 11. Phillip Honenberger (UNLV): All Knowing is Orientation: Marjorie Grene's Ecological Epistemology -- 12. Alvaro Moreno (IAS, San Sebastian): What is life? The historical dimension of biological organization -- 13. Cécilia Bognon-Küss (Louvain-La Neuve): The concept of metabolism, biological identity and the challenges from microbiome research.
    Abstract: This Open Access book combines philosophical and historical analysis of various forms of alternatives to mechanism and mechanistic explanation, focusing on the 19th century to the present. It addresses vitalism, organicism and responses to materialism and its relevance to current biological science. In doing so, it promotes dialogue and discussion about the historical and philosophical importance of vitalism and other non-mechanistic conceptions of life. It points towards the integration of genomic science into the broader history of biology. It details a broad engagement with a variety of nineteenth, twentieth and twenty-first century vitalisms and conceptions of life. In addition, it discusses important threads in the history of concepts in the United States and Europe, including charting new reception histories in eastern and south-eastern Europe. While vitalism, organicism and similar epistemologies are often the concern of specialists in the history and philosophy of biology and of historians of ideas, the range of the contributions as well as the geographical and temporal scope of the volume allows for it to appeal to the historian of science and the historian of biology generally. .
    Note: Open Access
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  • 26
    ISBN: 978-3-8394-6377-2
    Language: English
    Pages: 1 Online-Ressource (248 Seiten) : , Illustrationen, Diagramme.
    Series Statement: Science studies
    Parallel Title: Erscheint auch als
    RVK:
    RVK:
    RVK:
    RVK:
    RVK:
    Keywords: Klima. ; Klimaänderung. ; Technologie. ; Nachhaltigkeit. ; Ressourcen. ; Technology and Society ; Big Societal Challenges ; Transdisciplinary Research ; Lightweight Design ; Sustainability ; Technology ; Economy ; Gender ; Sociology of Technology ; Gender Studies ; Medicine ; Sociology ; Klima ; Klimaänderung ; Technologie ; Nachhaltigkeit ; Ressourcen
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 27
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    Nijmegen : Radboud University Press
    Language: Undetermined
    Pages: 1 Online-Ressource (38 p.)
    Keywords: History ; Medicine
    Abstract: On 15 October 2020, in the middle of the COVID-19 pandemic, Dr. Souha Kanj received a Radboud honorary doctorate in recognition of her achievements in the field of infection control and prevention, efforts in antimicrobial stewardship, and research on various infectious diseases, particularly antimicrobial resistant (AMR) bacteria. This edition includes the laudatio and the speech of our honorary doctor. Kanj published the first overview of antibiotic resistance in Arab countries and discovered differences between neighboring countries in the epidemiology of antimicrobial resistance. She also developed infection prevention monitoring and education programs for healthcare workers, and private organizations in the Arab world. Thanks to her efforts, Lebanon has signed the WHO pledge for hand hygiene. Kanj is not only commended for her expertise, didactic skills, and contribution to medicine, but also for her resilience and strong belief in making a positive impact, despite the difficult journey she has been through, having studied during the Lebanese civil war and being faced with numerous challenges that hit Lebanon and the region after that
    Note: English
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  • 28
    ISBN: 9783036564111 , 9783036564104
    Language: Undetermined
    Pages: 1 Online-Ressource (334 p.)
    Keywords: Medicine
    Abstract: Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells
    Note: English
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  • 29
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036564678 , 9783036564661
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine
    Abstract: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars
    Note: English
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  • 30
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    [Erscheinungsort nicht ermittelbar] : University of California Press
    ISBN: 9780520388710
    Language: Undetermined
    Pages: 1 Online-Ressource (217 p.)
    Keywords: Political economy ; Medicine
    Abstract: Capitalizing a Cure takes readers into the struggle over a medical breakthrough to investigate the power of finance over business, biomedicine, and public health. When curative treatments for hepatitis C launched in 2013, sticker shock over their prices intensified the global debate over access to new medicines. Weaving historical research with insights from political economy and science and technology studies, Victor Roy demystifies an oft-missed dynamic in this debate: the reach of financialized capitalism into how medicines are made, priced, and valued. Roy’s account moves between public and private labs, Wall Street and corporate board rooms, and public health meetings and health centers to trace the ways in which curative medicines became financial assets dominated by strategies of speculation and extraction at the expense of access and care. Provocative and sobering, this book illuminates the harmful impact of allowing financial markets to determine who heals and who suffers and points to the necessary work of building more equitable futures. “An important voice on the links between finance and health ecosystems, Victor Roy makes a valuable contribution to building an economy that is based on providing health for all.” — Mariana Mazzucato, author of The Value of Everything: Making and Taking in the Global Economy and Chair of the WHO Council on the Economics of Health for All “This book is a riveting read that will strike fear in the heart of anybody who cares about the right to health or thinks that the drive for profits should not supersede democracy or human need.” — Salmaan Keshavjee, author of Blind Spot: How Neoliberalism Infiltrated Global Health “The best piece of nonfiction I have read in a long time. This book offers a fantastic, relevant, and necessary case study to understand how the financialization of the economy has affected the organization of industrial sectors.” — Marc-André Gagnon, Professor of Public Policy and Political Economy, Carleton University
    Note: English
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  • 31
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036569604 , 9783036569611
    Language: Undetermined
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Medicine
    Abstract: Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments
    Note: English
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  • 32
    ISBN: 9783036566726 , 9783036566733
    Language: Undetermined
    Pages: 1 Online-Ressource (672 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint covers some significant impacts in the recent research in both the private and public sectors of cancer diagnosis and therapy, in which Artificial Intelligence (AI) and Machine Learning are significant. This reprint is also a collection of forty different complex and challenging problems arranged in five groups: AI in prognosis, grading, and prediction, AI in clinical image analysis, AI models for pathological diagnosis, ML and statistical models for molecular cancer diagnostics and genetics, and AI in triage, risk stratification, and screening cancer, which are all focused on using AI in cancer diagnosis and therapy. All the necessary concepts, solutions, methodologies, and references are supplied except for some fundamental knowledge that is well-known in the general fields of AI and cancer diagnosis and therapy. The readers may, therefore, gain the main concepts of each chapter, with as little of a need as possible to refer to the concepts of the other chapters and references. The readers may hence start to read one or more chapters of the book for their own interests
    Note: English
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  • 33
    ISBN: 9783036572017 , 9783036572000
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The Special Issue "Focus on Antibiotics - New Challenges and Steps Forward in Discovery and Development" addresses the latest efforts towards discovering new antibiotics. The articles in this Special Issue cover various topics concerning antibacterial drugs. They provide valuable insights into the challenges and opportunities facing the field of antibiotic research and offer innovative solutions to tackle the growing problem of antibiotic resistance. The content of this Special Issue addresses antibacterial quinolones of the latest generation, new tetracyclines (such as glycylcyclines, aminomethylcyclines, and fluorocyclines), metal complexes (Ru (II/III) frameworks and Co(III) complexes with diamine chelate ligands), various nanoparticles (gold, silver and titanium dioxide nanoparticles), bioactive compounds produced by Mixobacterials species, anti-mycobacterial compounds acting as phosphopantetheinyl transferase inhibitors. The research in this Special Issue will contribute to pharmaceutics and ultimately contribute to developing new and effective antibiotics. We are grateful to the authors for their contributions and hope this Special Issue will stimulate further research and discussion on antibiotics. We also thank the reviewers for their time and expertise, and the editorial team for supporting this Special Issue. Finally, we hope this Special Issue will serve as a valuable resource for researchers, clinicians, and policymakers working towards a future where antibiotics remain vital in our fight against infectious diseases
    Note: English
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  • 34
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036568966 , 9783036568973
    Language: Undetermined
    Pages: 1 Online-Ressource (320 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs
    Note: English
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  • 35
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036570624 , 9783036570631
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Medicine
    Abstract: Diet contributes to the development of many chronic conditions including obesity, cardiovascular disease, hypertension, stroke, type 2 diabetes, metabolic syndrome, some cancers, non-alcoholic fatty liver disease, and potentially some neurological diseases. This reprint addresses associations between diet (and specific nutrients including vitamin D) and various chronic diseases including obesity, cardiovascular disease, hypertension, stroke, diabetes, metabolic syndrome, non-alcoholic fatty liver disease, neurological conditions, and age-related macular degeneration. More specifically, the impacts of plant-based diets, dairy products, and ketogenic diets are explored in relation to chronic disease risk as well as some benefits of the consumption of oral nutritional supplements in the prevention of malnutrition and sarcopenia and in the treatment of wounds in individuals with diabetes. Additional topics that are covered include some roles of the fatty acid arachidonic acid in the body and the impact of cellular mitochondrial dysfunction on the progression of age-related macular degeneration. The effectiveness of a variety of nutraceuticals is covered as a means for the prevention or treatment of age-related macular degeneration. Lastly, the use of olive oil in reducing gut permeability in those with pre-diabetes is addressed, as well as the complex relationships of diet/food and of disease (metabolic syndrome) with the gut microbiota
    Note: English
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  • 36
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036569161 , 9783036569178
    Language: Undetermined
    Pages: 1 Online-Ressource (274 p.)
    Keywords: Medicine ; Oncology
    Abstract: Tumor progression is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors. Inflammatory infiltration contributes to tumor progression and metastatic process, and there are many reports of associations between tumor inflammatory infiltration, progression and prognosis. New therapeutic approaches have been developed with the aim to control tumor progression through the targeting of different components of the tumor microenvironment. This reprint will be useful for anyone who wants to learn about cancer: professors and students at universities, scientists at research institutes, biotechnology, and pharmaceutical labs, and lawyers trying to understand the patent literature
    Note: English
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  • 37
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036567402 , 9783036567419
    Language: Undetermined
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic
    Note: English
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  • 38
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036569369 , 9783036569376
    Language: Undetermined
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medicine
    Abstract: The objective of this reprint is to present the main evidence-based data on new developments and knowledge in diagnostic and treatment technologies in the orofacial field used in both children and adults. The published content has been met with great success in interdisciplinary fields, stimulating international authors to submit their original articles, reviews, or case reports based on various aspects of orthodontics as well as on the diagnosis and management of temporomandibular disorders and orofacial pain. Among the current highly debated topics, this reprint focuses on multiple disciplines as follows: gingival recessions and periodontal status after orthodontic treatment; a rare case of impacted central incisors; predictors of analgesic consumption in orthodontic patients; a systematic review about different dentoskeletal class III treatment approaches; evaluation of upper airway volumes; and cephalometric values in JIA patients
    Note: English
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  • 39
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036562773 , 9783036562780
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed
    Note: English
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  • 40
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036563381 , 9783036563398
    Language: Undetermined
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medicine
    Abstract: Hepatic encephalopathy (HE) is a complex neurological syndrome, characteristic of patients with liver disease, that causes a wide and complex spectrum of nonspecific neurological and psychiatric manifestations, ranging from a subclinical entity such as minimal or covert hepatic encephalopathy to a deep form in which a complete alteration of consciousness can be observed: overt hepatic encephalopathy. Both minimal and overt hepatic encephalopathy have a high impact on patients, caregivers, and national health services, driving substantial consumption of economic resources. In this Special Issue, we discussed the current state-of-the-art research, address ongoing knowledge gaps, and ongoing controversies related to the pathogenesis, diagnosis, and therapeutic management of hepatic encephalopathy
    Note: English
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  • 41
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036561042 , 9783036561035
    Language: Undetermined
    Pages: 1 Online-Ressource (242 p.)
    Keywords: Medicine
    Abstract: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration
    Note: English
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  • 42
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036559698 , 9783036559704
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches
    Note: English
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  • 43
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036563855 , 9783036563848
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: This reprint is a compilation of ten publications, including original-research and review articles, and the accompanying editorial within the scope of a Special Issue entitled: "State of the Art in Idiopathic Pulmonary Fibrosis" published in Cells
    Note: English
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  • 44
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036570068 , 9783036570075
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint aims to provide an update on the biomedical imaging technologies that can be used for cardiovascular diseases, including Doppler echocardiography, magnetic resonance imaging and positron emission tomography. Cardiovascular disease imaging assessment includes anatomy, hemodynamics, and tissue biomarkers, which aid the stratification of patient risk and therapy. In addition, this Special Issue includes articles that discuss the recent integration of artificial intelligence and machine learning, in order to support novel approaches to personalized image-based diagnosis
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  • 45
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036568522 , 9783036568539
    Language: Undetermined
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint focuses on field studies aimed at unraveling the complex networks created by interactions between parasites and hosts in a given ecosystem. Since most transboundary diseases have been propagated from the wilderness to anthropized areas, societies are increasingly concerned about the relevance of wildlife as it pertains to global health. In this respect, research on parasites that may affect the biology and population equilibrium of wildlife is of major interest, especially when a One Health perspective is considered. The studies compiled in the present Special Issue fall within several areas of interest, such as epidemiology, diagnosis, emerging zoonoses, food safety, conservation issues, parasite–host interactions, and the pathology of infections caused by parasites in wild host species
    Note: English
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  • 46
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036568881 , 9783036568898
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine ; Pharmacology ; Research & information: general ; Chemistry
    Abstract: The Special Issue reprint covers a wide range of applications of 3D-printing in dentistry. Five out of eleven research papers deal with applications of 3D printing in orthodontics, one study presents a 3D-printed fitting system for the FFP2 that were applied during the COVID-19 pandemic, and the others address applications in prosthodontics and restorative dentistry
    Note: English
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  • 47
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036570037 , 9783036570020
    Language: Undetermined
    Pages: 1 Online-Ressource (360 p.)
    Keywords: Medicine
    Abstract: Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones
    Note: English
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  • 48
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036570457 , 9783036570440
    Language: Undetermined
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Medicine
    Abstract: This reprint, guest edited by Anne-Marie Caminade, gives an impressionist overview of the current state of the art about “Personalized and Precision Medicine”. Twenty contributions illustrate the diversity of the topic, including new approaches about cancers, neurodegenerative diseases, infectious diseases, lungs obstruction, skeletal diseases, intestinal microbiomes, new tools such as ultra-high-frequency ultrasound or non-oncological radiotherapy, and a new class of drugs (dendrimers). This reprint is an illustration of the present and future impact of Personalized and Precision Medicine on all the therapeutic domains
    Note: English
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  • 49
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036575988 , 9783036575995
    Language: Undetermined
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke
    Note: English
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  • 50
    ISBN: 9783036574806 , 9783036574813
    Language: Undetermined
    Pages: 1 Online-Ressource (94 p.)
    Keywords: Medicine
    Abstract: This book is a collection of articles focused on recent research covering a species which is emblematic of scientific and commercial interest—the dromedary. The dromedary economy and its sustainability are of a capital importance for the future development of humanity. This research highlights camel productions systems and rearing practices, camel biodiversity and genetics, camel breeding and feeding, dromedary pathologies, anatomy particularities in dromedary, therapeutic virtues of camel products, as well as the industry’s contribution to food security
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  • 51
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036575261 , 9783036575278
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas, between 5°N and 5°S latitudes, spanning over 118 countries. The special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for the metabolic pathway via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have taken the limelight as an attractive biodiversity hotspot, attracting significant attention from organic chemists and pharmacologists. Additionally, many unique and novel chemical structures with a wide range of structural classes have suggested various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles describing recent studies and pertinent reviews focusing on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of putting together a group of top researchers whose work we would like to feature in this collection, and we would like you to participate
    Note: English
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  • 52
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036577081 , 9783036577098
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases
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  • 53
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036574349 , 9783036574356
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Recently, Chinese researchers have made significant progress in animal venom research in comprehending the diversity and complexity of these molecules and their potential applications in medicine, biotechnology, and as research tools. Advancements in 'omics' technologies such as proteomics, genomics, and transcriptomics have empowered Chinese researchers to identify and analyze venom-coded genes and proteins, revealing a kaleidoscope of novel peptide toxins with diverse functions and activities. The reprint focus on the perspective on some of the most recent and dynamic contributions of animal toxins research by Chinese researchers. The purpose of this reprint is to provide the latest work by Chinese researchers on the discovery of animal toxins, the mechanism underlining their actions, the mining of drug leads from peptide toxins, and the diagnosis and treatment of bites or stings by venomous animals
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  • 54
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036577005 , 9783036577012
    Language: Undetermined
    Pages: 1 Online-Ressource (162 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Dual disorders, meaning the coexistence in the same individual of a substance use disorder and another mental disorder, have become an area of great interest in the fields of psychiatry and addiction and in health overall due to their high prevalence, clinical relevance and multicultural presence. This book includes a compilation of papers published between the end of 2021 and the beginning of 2023 focused on recent advances in dual disorders. The contributions present a broad look at various relevant aspects. Among them are the characterization of patients treated in different services, with special interest in the risk of overdoses, suicidal attempts and HIV, as well as the so-forgotten gender perspective and the impact of the COVID-19 pandemic on the attention of addiction centers. One of the first studies to consider the comorbidity of gambling disorders with substance use is also presented. The possible usefulness of explanatory models of machine learning for diagnosis and for performing chronobiological measurements that allow a more individualized treatment stand out among the novel contributions to the field of dual disorders. The aim of each of the contributions of this reprint is to be transferred for the benefit of clinical practice
    Note: English
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  • 55
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036557311 , 9783036557328
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine
    Abstract: This book follows up on the previous volume focusing on the different biomarkers for neurodegenerative diseases. It includes original research works and review articles focusing on an improved understanding of disease mechanisms. It also aims to identify aspects of early therapeutic intervention for enhanced disease management. Some critical approaches include studies involving human tissue samples, mouse disease models, and different imaging techniques. These studies present the essential information necessary to address such pathological conditions in the future
    Note: English
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  • 56
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036575926 , 9783036575933
    Language: Undetermined
    Pages: 1 Online-Ressource (508 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Arthritis has a high prevalence globally and includes over 100 types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features of the disease, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used in the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of heart attack and other cardiovascular problems. It is therefore crucial that we continue to research the pathogenesis of arthritis and seek to discover novel modes of therapy. This reprint summarizes the themes of the 29 articles published in our Special Issue “Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0”. This reprint details important novel research discoveries that contribute to our current understanding of arthritis
    Note: English
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  • 57
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036576992 , 9783036576985
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery
    Note: English
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  • 58
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036575759 , 9783036575742
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint, edited by Prof. Gaetano Santulli, MD, PhD, collects the most up-to-date peer-reviewed scientific papers dealing with cardiovascular medicine, from basic science to pre-clinical and clinical investigations, highlighting the fundamental importance of translational medicine in the challenging quest for new therapies to cure cardiovascular disease. Indeed, cardiovascular disease is the leading cause of death worldwide, and the search for novel mechanisms and therapeutics is desperately needed. Therefore, both basic and translational studies in the cardiovascular field represent a paramount strategy to identify novel therapeutic targets and improve the quality of life of patients with cardiovascular disorders
    Note: English
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  • 59
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036574660 , 9783036574677
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine
    Abstract: There is growing evidence that among persons with disordered eating behavior, the identification of an “addictive-like eating” phenotype for some persons could be relevant and improve our ability to design better tailored interventions. This “addictive-like eating behavior” phenotype encompasses different terms or concepts, including “food addiction”, “eating addiction”, “compulsive eating behavior”, and “food craving”, but also applies to some persons with binge eating disorder, bulimia nervosa, anorexia nervosa, or binge eating symptoms. Although these terms may theoretically refer to different underlying causes or conceptualizations of addictive-like eating, all agree on the complex and multifaceted public health problem it represents and on the similarities it shares with other addictive disorders in terms of etiology, epidemiology, and treatment. Addictive-like eating behavior can deleteriously impact the patient’s outcome and may lead to poorer weight loss evolution, increased prevalence of co-occurring medical and/or psychiatric disorders, and/or lower quality of life. One of the key challenges for the present and future research is to better identify this subpopulation of patients exhibiting this addictive-like eating phenotype, and to identify the psychological/psychiatric factors and biological mechanisms underlying this increased vulnerability to addictive-like eating. Such preliminary knowledge is crucial for enabling the development of interventions targeting these vulnerability risk factors and, ultimately, improving patient outcomes
    Note: English
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  • 60
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036575056 , 9783036575049
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine
    Abstract: Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma
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  • 61
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036576794 , 9783036576787
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Since the introduction of robotic surgery in the early 2000s, several studies have demonstrated its safety and feasibility in various complicated procedures, including esophageal, gastric, and colorectal surgery (for both benign and malignant pathologies), hepatobiliopancreatic surgery, and gynecological and urological procedures.Robot-assisted surgery provides the advantages of a magnified tridimensional view and movement stability without a tremor, which facilitate a precise dissection. The EndoWrist instrument also facilitates dissection at difficult angles, thus enabling surgery in complex conditions.Even if some of the advantages of robotic surgery have been defined, we are still far from clearly recognizing precise indications for a robotic approach in gastrointestinal surgery.With this Special Issue, we aim to investigate the conditions that support the robotic approach in gastrointestinal surgery toward the definition of gold-standard robotic procedures, as established in urological surgery for prostatectomy
    Note: English
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  • 62
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036568683 , 9783036568690
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Medicine
    Abstract: Insects are the most diverse group of organisms, representing approximately 80 percent of the world's species. It is estimated that there are some ten quintillion individual insects alive. During millions of years of evolution, insects developed extraordinary adaptations that allowed them to reside in different habitats. As with all other organisms, insects encounter a wide range of microbes. Although lacking adaptive immunity, they rely on robust innate immune systems to combat these microbes to maintain organismal homeostasis. Conversely, some microbial communities can benefit the host and profoundly affect the host's physiology and overall fitness. Microbiotas have been proven to provide nutrients, promote host defense, and mediate host reproductive behavior. In recent decades, the emergence of high-throughput sequencing has enabled researchers to study host–microbe interactions from the whole microbiome level rather than single microbial species, greatly expanding our knowledge of insect biology
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  • 63
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    Nijmegen : Radboud University Press
    ISBN: 9789493296022
    Language: Undetermined
    Pages: 1 Online-Ressource (378 p.)
    Keywords: Anatomy ; Diseases & disorders ; History ; Medicine ; Pathology
    Abstract: This book offers exciting and often surprising insights into one hundred diseases that have emerged over the past century. The authors focus on the period from 1923, when Radboud University was founded, to 2023, the university's centennial anniversary. All of the diseases included in this book have left an indelible mark on the century in which they emerged, in either a scientific and/or socio-historic sense. This book can therefore be read as a series of descriptions of time-specific degenerative disorders, inflammations, infections, malignant neoplasms, immunological diseases, developmental disorders, genetic diseases and psychiatric disorders. All of the descriptions are accompanied by vivid illustrations, the majority of which come from the Museum of Anatomy and Pathology at Radboud university medical center. Each disease description also includes a critical commentary and a brief historical framework. Scientific findings by Dutch and Nijmegen researchers are highlighted, where applicable. Finally, each disease description also includes an English summary. The book A Century of Diseases is accessible to a wide audience of readers with an interest in pathology, ranging from students and staff at Radboud University and Radboud university medical center to those involved in all facets of healthcare, from professionals to patients
    Note: English , Dutch
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  • 64
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036573274 , 9783036573267
    Language: Undetermined
    Pages: 1 Online-Ressource (352 p.)
    Keywords: Medicine
    Abstract: In this Special Issue, "Pathogenesis of Pregnancy-Related Complications", 4 reviews, 13 original papers, 1 communication, and 1 case report are compiled. These papers were published by scientific teams from 24 countries, including China, Tunisia, Canada, France, Serbia, Portugal, Spain, Chile, Singapore, Australia, the USA, Mexico, the Czech Republic, Germany, Sweden, Finland, the United Kingdom, Norway, Poland, Greece, Japan, Italy, Switzerland, and Israel, which is a really great achievement
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  • 65
    ISBN: 9783036582405 , 9783036582412
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: Nanomedicine is a special medical field focused on the application of nanotechnology to provide innovations for healthcare in different areas, including the treatment of a wide variety of diseases, including cancer, infections, and auto-immune disorders. The field emerged during the 1980s, aligning with the approval of the first regulatory-agency-approved nanomedical oncological drugs. Additionally, nanotechnology has played a pivotal role in the development of mRNA vaccines utilized during the COVID-19 pandemic, further establishing its enduring significance in the domains of science and biomedical innovation. The reasons for the use of nanotechnology in biomedicine can vary but are mostly the protection and/or delivery of bioactive molecules to target tissues. The general idea is to create nanoscopic platforms that can interact differently with biological systems, either through pharmacokinetic modifications or through the preferential activation of some biological pathway. The intricate biomolecular interactions that underlie the functioning of the biological system take place within the nanoscale. So, nanoparticles can be designed to be similar in size to key biological structures like large biomolecules or small organelles, enabling them to interact with biological systems in unique ways, which can improve the effects of drugs used in the treatment of certain diseases. In other words, highly distinct and improved biological effects can emerge from such interactions
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  • 66
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036562636 , 9783036562643
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Globally, the impact of differentiated thyroid cancers has significantly increased in the last decade, resulting in growth of public health spending. Many international scientific societies are actively involved in the difficult process of building updated guidelines in response to scientific research, especially in the genetic and immunohistochemistry fields. The watch, wait, and see policy has added a new possibility for patients in selected cases. Considering the recognized international interest in this disease, this Special Issue aims to analyze the most recent acquisitions in terms of the diagnosis and therapy of differentiated thyroid cancer. It will offer the reader an updated point of view of the most illustrious endocrinology and endocrine-surgery international schools
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  • 67
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036562377 , 9783036562384
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The importance of studying pollution via potentially toxic elements (PTEs) is becoming a key challenge considering the increasing concern about the presence of PTEs in the environment and their potential impacts on ecosystem functioning and public health due to their persistence and biotoxicity. Regional geochemical research, together with geostatistical computations which are used to identify source patterns of different pollutants related to the underlying geological features and/or anthropogenic activities, is the best approach for characterizing this pollution issue. The collection of research in this Special Issue, “Potentially Toxic Element Pollution in Urban and Suburban Environments”, represents the need of the scientific community to characterize the behavior, transport, fate, and ecotoxicological state of PTEs in environmental matrices in both urban and suburban settings. All the case studies collected are of relevant significance due to their quality, both in the methodologies and the achieved results, and interest to different environmental studies, from China to South Africa to Europe. My role as Guest Editor of this Special Issue was exciting and stimulating. I would like to express my appreciation to all the authors for submitting their original contributions and to the reviewers for their essential role in the process. I would like to thank the editors of Toxics and, in particular, Selena Li for her precious and tireless support
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  • 68
    ISBN: 9783036562124 , 9783036562117
    Language: Undetermined
    Pages: 1 Online-Ressource (214 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD
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  • 69
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036560878 , 9783036560885
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The Special Issue provides twelve contributions, of which three original articles, seven narrative reviews, one systematic review, and one meta-analysis that, altogether, offer a multifaceted and multidisciplinary overview that allows to draw a picture as intriguing and fascinating as possible on the benefits of curcumin and also to suggest potential fields of activities still to be explored. Among the biological activities exerted by curcumin, the anti-oxidative and anti-inflammatory properties reported in many studies make it a potential effective tool in preventing and counteracting chronic-degenerative diseases, very often associated with obesity and aging, such as cardiovascular diseases, T2D, metabolic dysfunctions, neurodegenerative diseases, and cancer, all of them characterized by the presence of oxidative and inflammatory processes. The main concerns that arise from the evaluation of the preventive/therapeutic effects of curcumin are, first of all, the still small number of randomized placebo-control studies available; in addition, small sample sizes have generally been considered, and different protocols and different formulations as well as different routes of administration of curcumin have been used. Thus, it is quite difficult to compare the results and to provide a standard protocol for the use of this promising natural compound. For these reasons, and taking in account the growing use of curcumin by the general population, further investigations to confirm and expand current findings are mandatory and research on curcumin and its effects on human health have to be fostered and promoted
    Note: English
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  • 70
    ISBN: 9783036562261 , 9783036562254
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated
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  • 71
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036563213 , 9783036563206
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases
    Note: English
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  • 72
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036564470 , 9783036564463
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine
    Abstract: The majority of newborns do not need medical interventions to manage the neonatal transition after birth. However, every year millions of newborns worldwide require respiratory support immediately after birth, and another considerable number of newborns additionally require extensive resuscitation including chest compressions and drug administration. Despite a significant increase in knowledge and development of enhanced therapy strategies over the past few years, morbidity and mortality caused by failures in neonatal transition remain an important health issue. The purpose of this reprint is to support or introduce novel concepts and add information in the area of the “Stabilization and Resuscitation of Newborns”, aiming to improve neonatal care and, as the major objective, to enhance neuro-developmental outcomes
    Note: English
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  • 73
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036564289 , 9783036564296
    Language: Undetermined
    Pages: 1 Online-Ressource (358 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
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  • 74
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036565477 , 9783036565460
    Language: Undetermined
    Pages: 1 Online-Ressource (294 p.)
    Keywords: Medicine ; Oncology
    Abstract: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human development.In clinics, despite advances of diagnosis and surgical procedures, 20% of the patients with CRC present with metastasis at the time of diagnosis, caused by residual tumor cells that have spread to distant organs prior to surgery, affecting the patient survival rate. Standard systemic chemotherapy, alternative therapies that target mechanisms involved in cancer progression and metastasis, immunotherapy, and combination therapies are the major CRC-treatment strategies. In the advanced stage of CRC the transforming growth factor-beta (TGF-β) plays an oncogenic role by promoting cancer cell proliferation, cancer cell self-renewal, epithelial-to-mesenchymal transition, invasion, tumor progression, metastatic spread, and immune escape. Furthermore, high levels of TGF-β1 confers poor prognosis and is associated with early recurrence after surgery, resistance to chemo- or immunotherapy, and shorter survival. Based on the body of experimental evidence indicating that TGF-β signaling has the potential to be a good therapeutic target in CRC, several anti-TGF-β drugs have been investigated in cancer clinical trials. Here, we presented a comprehensive collection of manuscripts regarding studies on targeting the TGF-β signaling in CRC to improve patient’s prognosis and personalized treatments
    Note: English
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  • 75
    ISBN: 9783036563183 , 9783036563190
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories
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  • 76
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036562698 , 9783036562704
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins
    Note: English
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  • 77
    ISBN: 9783036561349 , 9783036561332
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions
    Note: English
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  • 78
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036564173 , 9783036564166
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB)
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  • 79
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036562148 , 9783036562131
    Language: Undetermined
    Pages: 1 Online-Ressource (282 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders
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  • 80
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036569680 , 9783036569697
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine ; Oncology
    Abstract: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit
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  • 81
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036567846 , 9783036567853
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medicine
    Abstract: The Special Issue “Marine Anti-Inflammatory and Antioxidants Agents 2.0” collects in vitro and/or in vivo experimental investigations highlighting the role of marine-derived bioactive compounds as modulators of inflammation and/or oxidative stress, papers describing the mechanisms of action and molecular interactions of compounds isolated from marine organisms, and comprehensive review articles summarizing knowledge on marine anti-inflammatory and/or antioxidant agents in support of human health
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  • 82
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036567693 , 9783036567686
    Language: Undetermined
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Medicine
    Abstract: This reprint is an excellent collection of articles that deal with difficult-to-treat infections in the ICU environment. Multiresistant bacteria and fungi create severe treatment problems to the physician charged with their care. We hope that this book will help everyday dilemmas and add useful information on difficult topics
    Note: English
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  • 83
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036550374 , 9783036550381
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: In this Special Issue of Toxics entitled, “Chemical and biological threats, hazard potential and countermeasures”. In this special issue we would like to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally or on purpose endanger human health. Besides the characterization of such threats and their biological consequences we will focus on the available and novel experimental countermeasures capable to protect from and/or threat such exposures
    Note: English
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  • 84
    ISBN: 9783036573519 , 9783036573502
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medicine
    Abstract: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research
    Note: English
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  • 85
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036570907 , 9783036570914
    Language: Undetermined
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The lifestyle associated with good quality of food is well known for its widely recognized health benefits, especially when rich in bioactive compounds. Reduced risks of some types of cancer and other diseases have been associated with the adoption of such a diet, as have increased antioxidants, inhibitors of lipid peroxidation, decrease of pro-inflammatory cytokine production, etc. The focus of this Special Issue of Toxins was to gather advances related to the cytotoxicity of natural toxins and the potential for the cytoprotection of natural compounds present in food or plants. In this context, this Special Issue of Toxins comprises eight original contributions. Special attention is given to Fridericia chica (Bignoniaceae) leaves grown in Colombia, extract from Polygonum cuspidatum, Artemisia annua and coffee extracts against mycotoxins´ effects. Studies of mycotoxins in different animal and human cell lines are also presented for zearalenone, beauvericin, α-zearalenol and β-zearalenol, among others
    Note: English
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  • 86
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036573281 , 9783036573298
    Language: Undetermined
    Pages: 1 Online-Ressource (290 p.)
    Keywords: Medicine
    Abstract: This Special Issue covers current and relevant information about the applied anatomy of domestic animals, new companion animals and wild animals. It includes recent research and review articles on diverse topics based on the use of different diagnostic imaging techniques and more classic anatomical methods, providing a deeper insight into the healthy anatomy of diverse structures, which is crucial in high-quality medicine
    Note: English
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  • 87
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036574141 , 9783036574158
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Psychopathology, including functional psychiatric disorders, such as schizophrenia, bipolar disorder, major depressive disorder and anxiety disorders, and also dementia and challenging behaviour, is common in people with neurodevelopmental disorders (NDDs), such as intellectual and developmental disabilities (IDD), autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and is the cause for a major public health concern. Much research has been conducted in the last three decades to understand this issue and develop effective interventions. Still, a lot remains unknown, for which high-quality translational research is urgently needed. In this Special Issue, we drew together research on recent advances addressing these issues. The areas covered included life expectancy among people with and without intellectual disabilities, the social and emotional development of people with intellectual disabilities and ASD, the influence of external environmental factors in determining aggressive behaviour in people with intellectual disabilities, parent and child training for children with autism and intellectual disabilities, how the presence of deafness influences quality of life, the views of prescribers on the deprescribing of antipsychotics among adults with intellectual disabilities, the views of people with intellectual disabilities who took part in the deprescribing, the views of direct-care workers on the causes of challenging behaviours in people with intellectual disabilities, and the validation of tools to detect cognitive decline in adults with intellectual disabilities
    Note: English
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  • 88
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036574592 , 9783036574585
    Language: Undetermined
    Pages: 1 Online-Ressource (266 p.)
    Keywords: Medicine
    Abstract: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond
    Note: English
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  • 89
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036572550 , 9783036572543
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medicine
    Abstract: This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship;Diagnostic stewardship;Influence of antimicrobial utilisation changes in antimicrobial resistance;Impact of antimicrobial stewardship on quality performance measures and patient outcomes;Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers;Behavioural change approaches to antimicrobial stewardship;Collaborative practice agreements in antimicrobial stewardship;Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology);Tackling AMR through antimicrobial stewardship in low- and middle-income countries;Antimicrobial stewardship for animal health;Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals);Antimicrobial use and stewardship in the context of the COVID-19 pandemic;Global collaborations to tackle AMR through antimicrobial stewardship
    Note: English
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  • 90
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036572888 , 9783036572895
    Language: Undetermined
    Pages: 1 Online-Ressource (98 p.)
    Keywords: Medicine
    Abstract: Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, “Carbazole derivatives: latest progress and prospects”, recent studies on carbazole derivatives that are utilized, such as β1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported
    Note: English
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  • 91
    ISBN: 9783036571850 , 9783036571843
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine ; Oncology
    Abstract: Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease
    Note: English
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  • 92
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036571836 , 9783036571829
    Language: Undetermined
    Pages: 1 Online-Ressource (378 p.)
    Keywords: Medicine
    Abstract: Billions of people suffer from dental problems. Paradoxically, the deteriorating state of teeth is accompanied by the ever-increasing desire to preserve the best facial appearance, which is significantly influenced by teeth aesthetics. This favors the development of dental materials and manufacturing technologies for dental prosthetics, needed to achieve expected effects of clinical treatment.This reprint focus on enhancing antimicrobial and mechanical properties of polymeric materials and composites for dentistry. In recent years, special attention has been focused on the possibility of giving materials new or improved properties by the introduction of nano or submicron size additives, fibers or whiskers. Using agents such as natural oils to enhance antimicrobial properties remains an exciting idea. Another area of research is the application of antibacterial monomers, which can be copolymerized in resins to kill oral pathogenic microflora. The use of new monomers or new compilations of various monomers to improve mechanical properties has also aroused interest. In addition, we are currently looking for new data regarding colonization of dental materials by pathogenic microbes and their influence on the other properties. Further, there are many new commercially available materials which should be investigated to verify their properties, which is important from the point of view of clinical practice. Original new research and reviews related to any of the topics mentioned above indicate the current directions of development of dental materials. We hope that the presented work will be of interest to readers
    Note: English
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  • 93
    ISBN: 9783036569345 , 9783036569352
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: It is a great pleasure to provide you this Special Issue of Nutrients related to the 5th International Conference “Vitamin D—Minimum, Maximum, Optimum”, under the auspices of the European Vitamin D Association (EVIDAS). The conference and the forthcoming papers serve as an international forum for the presentation and discussion of current basic and clinical research in the field of vitamin D. Organizing this subsequent Special Issue was truly challenging, given that vitamin D has recently been shown by prestigious medical journals to be an epiphenomenon that coincides with diseases, and that the correction of vitamin D deficits has limited clinical meaning. On the other hand, it was recognized that vitamin D deficiency is a global health problem with potential negative consequences on health, welfare, and morbidity during growth and adulthood, therefore influencing healthcare services worldwide. Thus, due to mutually exclusive conclusions, it was essential to discuss and share scientific reports and evidence demonstrating both the benefits and lack thereof in relation to human health. Prof. Dr. Pawel Pludowski Guest Editor
    Note: English
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  • 94
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036572765 , 9783036572772
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine
    Abstract: Today, a great variety of contraceptive techniques are available to women; this, coupled with improving the educational levels of female children and adults, is hastening a decline in fertility and consequently, population growth. With the advent of sustained fertility rates lower than replacement levels in many countries, including China and India, we are already witnessing major economic, social, environmental, and geopolitical consequences. Given this situation, today, the promotion of the use of contraception means improving health, not demography, placing emphasis on individuals and not just on methods alone; on the quality of services, and not simply on availability. Indeed, there is an increasing awareness that contraception can help women reduce health risks that are associated with reproductive events and specifically, with unwanted pregnancies. This means that, no matter how ideal a method may be from a purely scientific viewpoint, it must be submitted to the free, decision-making of well-informed women. To contribute to this new user-centric perspective, this reprint presents a series of articles in which technology is considered withing the broader concept of women’s health. Five articles deal with issues related to the users’ and providers’ perspectives; three discuss a modality that is receiving increasing attention, the so-called Long-Acting Reversible Contraception (LARC); and the last three contributions highlight the new advances in oral hormonal contraception
    Note: English
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  • 95
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036572697 , 9783036572680
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors
    Note: English
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  • 96
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036570617 , 9783036570600
    Language: Undetermined
    Pages: 1 Online-Ressource (304 p.)
    Keywords: Medicine
    Abstract: By joining the two previous editions, this Special Issue completes the trilogy of Special Issues entitled "Biological and Pharmacological Activity of Plant Natural Compounds", which deal with the properties and effects of phytonatural products in preclinical models. This third edition has also remained focused on their therapeutic potential, with the aim of increasing and contributing to the expansion of our scientific knowledge on plants in human health. We hope readers will enjoy this Special Issue as much as the previous publications
    Note: English
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  • 97
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036566917 , 9783036566900
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Oncology
    Abstract: Based on this evidence, a deep understanding of the immunological status and biological targets modulating immunological microenvironments should be quite informative for the development of future immunotherapy in HCC. From this point of view, this Special Issue will highlight the current state of the art in the immunotherapy of HCC from both the basic and clinical perspectives, and outline future perspectives for improving therapies
    Note: English
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  • 98
    ISBN: 9783036578460 , 9783036578477
    Language: Undetermined
    Pages: 1 Online-Ressource (256 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: This reprint focuses on relevant findings in the field of neuroscience, ranging from cognitive neuroscience, including studies on human consciousness, to clinical neurology, including studies on autism and epilepsy. Furthermore, the latest methods in the expanding field of neuroscience from cognitive to clinical subdisciplines will also be available to the readers
    Note: English
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  • 99
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036563619 , 9783036563602
    Language: Undetermined
    Pages: 1 Online-Ressource (366 p.)
    Keywords: Medicine
    Abstract: Biomaterials are an integral component of tissue engineering, and their development is crucial to the progress of new and efficient approaches in the regenerative medicine of bone, cartilage, tendons and ligaments, skin, soft-tissue wounds, cardiac muscle, vascular tissues, and neural tissues.Polymer-based biomaterials are extensively studied in the field of tissue engineering due to their biocompatible and biodegradable properties. This Special Issue is devoted to recent developments of synthetic and/or natural biomaterial scaffolds, hydrogels, polypeptides, polymer-based composites, and composites based on polymers and inorganic materials, such as bioactive ceramics and glasses. New technologies (e.g., bioprinting, additive manufacturing, etc.) used to form biomaterials for tissue engineering of three-dimensional (3D) constructs are of particular interest
    Note: English
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  • 100
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    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    ISBN: 9783036565750 , 9783036565743
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries
    Note: English
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