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  • MPI Ethno. Forsch.  (132)
  • MEK Berlin
  • MARKK
  • English  (132)
  • Italian
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (132)
  • Medical genetics  (80)
  • Neurology & clinical neurophysiology  (52)
Datasource
  • MPI Ethno. Forsch.  (132)
  • MEK Berlin
  • MARKK
Material
Language
Years
  • 1
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838819200 , 9781838819194 , 9781838819330
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: This book covers the latest developments in the understanding and treatment of traumatic brain injury. Various world experts authored the chapters that comprise a wealth of updated information on intracranial pressure; monitoring and diagnostic methods; neuroinflammatory responses in traumatic brain injury; cerebral palsy and Covid-19-related brain disorder; pathogenesis and prevention of fetal, neonatal, infant, and child brain injury; hyperbaric oxygenation treatment; the engineering and modeling of head injury; systematic review on early-tracheostomy; intracranial aneurysm in tuberous sclerosis complex; and the neurobehavioral and cognitive aspects of brain injury. With these complex topics, every clinician, scientist, and researcher will find this book invaluable in understanding the latest improvements and advances in the diagnosis and treatment of traumatic brain injury
    Note: English
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  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789855425 , 9781789855418 , 9781839627491
    Language: English
    Pages: 1 Online-Ressource (214 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: In the last decade, diverse research areas have developed novel approaches to overcome dysfunctions after a spinal cord injury (SCI). Even though motor restoration attracts the most clinical attention, sensory, autonomic, and mental health are also aspects fundamental to improving the quality of life of SCI patients. Over four sections of therapeutic, rehabilitation, and technological approaches, this book examines preclinical and clinical studies using mesenchymal stem cells and pharmacological or electrical stimulation strategies. Chapters also address the impact of paraplegia and associated loss of autonomic functions, including bowel and sexual dysfunction, as well as the convergence of new technologies aimed at providing postural support and enhancing mobility
    Note: English
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  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839623950 , 9781839623943 , 9781839623967
    Language: English
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Stroke continues to be a major public health issue. It is the third leading cause of death and disability across the globe. Its early identification and treatment along with prevention are major issues that confront a treating physician. We have understood the importance of early intervention and of the quote ‘time is brain’. Our endeavor now should be directed to the public at large and paramedics in particular. Although a stroke is a common condition, the availability of neurologists or stroke specialists is quite scarce. Today, management of a suspected case of stroke is done by a specialist team of medical and paramedical personnel. Advances in imaging, newer therapeutic agents, and endovascular management have revolutionized the management. Currently, we are witnessing a new era in the management of strokes and I am hopeful that continued research will get us to a satisfactory solution. This book along with another book from IntechOpen titled ‘Ischemic Stroke of Brain’ aims to improve the understanding of stroke medicine for postgraduate medical students in medicine and neurology who have an interest in stroke care
    Note: English
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  • 4
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838800420 , 9781838800413 , 9781839621673
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: This edited book, “Genotoxicity and Mutagenicity - Mechanisms and Test Methods”, aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species
    Note: English
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  • 5
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789856569 , 9781789856552 , 9781789857085
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medical genetics
    Abstract: Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics
    Note: English
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  • 6
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839624100 , 9781839624094 , 9781839624117
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: The book, Migraine, covers – to our best belief – the most important topics in migraine study, such as spontaneous primary headache, mostly from a clinical and therapeutic point of view. Special attention was paid to two hot topics in migraine problems: the chronic type of migraine and the new contemporary mode of treatment (for both episodic and chronic types) that is the use of monoclonal antibodies directed against the CGRP complex. The separate chapters cover the problem of medication overuse headaches, which is a growing condition among patients with migraine – especially the chronic migraine. The unique problem touched by the book is rarely discussed in literature of this field and it is the surgical attempts in the therapy of migraine. The authors of the book are widely recognized experts in migraines and related headaches that – we do believe – ensures a high quality of knowledge in the book. We hope that the presented monograph will be both attractive and helpful to all doctors interested not only in migraines but in other problems of idiopathic headaches
    Note: English
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  • 7
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789859805 , 9781789859799 , 9781839689789
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medical genetics
    Abstract: Chromosomes are vital components of genetic material, and, as such, distruption or changes to the structure of chromosomes can result in different health problems and deficits. This book explains chromosomal abnomalities and their effects on living organisms, including humans and plants. Classical and molecular cytogenetics techniques have a considerable number of potential applications, especially in clinical trials and biomedical diagnosis, making them a strong and insightful complement to other molecular and genomic approaches. Chapters cover topics including Down syndrome, fetal ultrasounds, acute myeloid leukemia, and Phelan-McDermid syndrome, among others
    Note: English
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  • 8
    ISBN: 9781789858921 , 9781789858914 , 9781789846225
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medical genetics
    Abstract: The book in your hands presents chapters revealing the magnitude of genetic polymorphisms that exist in different kinds of living beings. Natural populations contain a considerable amount of genetic change, which provides a genomic flexibility that can be used as a raw material for adaptation to changing environmental conditions. The analysis of genetic polymorphisms provides information about DNA sequence changes at a given locus. The increasing availability of PCR-based molecular markers allows for the detailed analyses and the detection of genetic changes influencing some important traits. The purpose of this book is to provide a glimpse into the dynamic process of genetic polymorphisms by presenting the thoughts of scientists engaged in the generation of new ideas and techniques employed for the assessment of genetic polymorphisms. The book should prove useful to students, researchers and experts in the area of molecular genetics
    Note: English
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  • 9
    ISBN: 9781838804404 , 9781838804398 , 9781839692611
    Language: English
    Pages: 1 Online-Ressource (348 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action
    Note: English
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  • 10
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838807740 , 9781838807733 , 9781838808006
    Language: English
    Pages: 1 Online-Ressource (118 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission
    Note: English
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  • 11
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838800321 , 9781838800314 , 9781838803186
    Language: English
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medical genetics
    Abstract: Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits
    Note: English
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  • 12
    ISBN: 9781789853605 , 9781789853599 , 9781789850994
    Language: English
    Pages: 1 Online-Ressource (356 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: “Brain circulation is a true road map that consists of large extended navigation territories and a number of unimagined and undiscovered routes.” Dr. Patricia Bozzetto Ambrosi This book combines an update on the review of cerebrovascular diseases in the form of textbook chapters, which has been carefully reviewed by Dr. Patricia Bozzetto Ambrosi, Drs. Rufai Ahmad and Auwal Abdullahi and Dr. Amit Agrawal, high-performance academic editors with extensive experience in neurodisciplines, including neurology, neurosurgery, neuroscience, and neuroradiology, covering the best standards of neurological practice involving basic and clinical aspects of cerebrovascular diseases. Each topic was carefully revised and prepared using smooth, structured vocabulary, plus superb graphics and scientific illustrations. In emphasizing the most common aspects of cerebrovascular diseases: stroke burden, pathophysiology, hemodynamics, diagnosis, management, repair, and healing, the book is comprehensive but concise and should become the standard reference guide for this neurological approach
    Note: English
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  • 13
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839629747 , 9781839629730 , 9781839629754
    Language: English
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Mental disorders can result from disruption of neuronal circuitry, damage to the neuronal and non-neuronal cells, altered circuitry in the different regions of the brain and any changes in the permeability of the blood brain barrier. Early identification of these impairments through investigative means could help to improve the outcome for many brain and behaviour disease states.The chapters in this book describe how these abnormalities can lead to neurological and mental diseases such as ADHD (Attention Deficit Hyperactivity Disorder), anxiety disorders, Alzheimer’s disease and personality and eating disorders. Psycho-social traumas, especially during childhood, increase the incidence of amnesia and transient global amnesia, leading to the temporary inability to create new memories.Early detection of these disorders could benefit many complex diseases such as schizophrenia and depression
    Note: English
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  • 14
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789855326 , 9781789855319 , 9781789856538
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Medical genetics
    Abstract: The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders
    Note: English
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  • 15
    ISBN: 9781838802929 , 9781838802912 , 9781839687723
    Language: English
    Pages: 1 Online-Ressource (274 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Clinical applications of neurostimulation or neuromodulation are experiencing rapid growth, driven by an evolution in neurotechnologies, the limitations of pharmacotherapy, and an improving understanding of brain physiology. New methods are promising for intractable or marginally tractable cognitive diseases and for adjunct therapies, as they offer greatly improved spatial and temporal resolution, thereby promising greater specificity and quicker recovery from disease. This book includes up-to-date and in-depth studies of many of these therapies, with chapters addressing their use in epilepsy, spasticity, pain, neurodegeneration, and spinal cord dysfunctions, among others, illustrating their versatility and therapeutic promise for cognitive dysfunction
    Note: English
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  • 16
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838805814 , 9781838805807 , 9781838805821
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS
    Note: English
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  • 17
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839629389 , 9781838808433 , 9781839629396
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Motor functions such as muscle strength and joint range of motion as well as somatosensory functions that enable a person to interpret bodily sensation are necessary and important for physical activity and exercise. Somatosensory and Motor Research is divided into three sections: “Somatosensory Research,” “Motor Research,” and “Relationship between Somatosensory and Motor Research.” Written by researchers and experts in the field, chapters in this volume address basic anatomy and physiology, treatment of sensory disorders, motor function, and somatic sensations. This book contributes to the understanding of both motor nerve and sensory nerve function and their involvement in the acquisition of movement
    Note: English
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  • 18
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789843323 , 9781789843316 , 9781839685576
    Language: English
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Multiple sclerosis is among the most frequent neurological diseases, which affect seriously the quality of life of a constantly increasing number of patients, inducing physical and mental invalidism with indefinite perspectives. The ongoing investigation of the pathogenetic background and the inconclusive analysis of many pathophysiological mechanisms and serious neuropathological alterations of the disease are dominant crucial topics in the field of neurosciences, aimed at tracing a definite way to a therapeutic approach. The authors of this volume attempt to throw light on the labyrinth of multiple sclerosis, approaching the disease from the viewpoint of epidemiology, autoimmune reactions, symptomatology, mental and physical decline, diagnostic procedures, prognosis, and treatment. The authors submit herein, along with scientific data, their hope of contributing effectively to ameliorating the quality of life of those suffering from multiple sclerosis who wait patiently for the day of recovery
    Note: English
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  • 19
    ISBN: 9781789852585 , 9781789852578 , 9781838803803
    Language: English
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Neuropathies are one of the main neurological problems in everyday life, and they still have many partially understood parts and unknowns both for physicians and patients. Many systemic conditions may exist within them and therefore they may be difficult to treat. In this book we provide current knowledge concerning neuropathies, which we believe you will find interesting. The subject ‘’neuropathies’’ comprises a number of topics, and each and every one could be the subject of a textbook. On the other hand, this book was never designed as one. This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that the book may be an inspiration for many young investigators as well. It contains current approaches and knowledge and we sincerely believe and hope that it will answer your queries regarding new perspectives about neuropathy in general
    Note: English
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  • 20
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789844931 , 9781789844924 , 9781789849820
    Language: English
    Pages: 1 Online-Ressource (294 p.)
    Keywords: Medical genetics
    Abstract: Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general
    Note: English
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  • 21
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789858907 , 9781789858891 , 9781839621185
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Keywords: Medical genetics
    Abstract: This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of phylogenetics. The book includes scholarly contributions by various authors, edited by experts pertinent to the field of phylogenetics. Each contribution comes as a separate chapter but is directly related to the book's topics and objectives. The target audience comprises scholars and specialists in the field
    Note: English
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  • 22
    Online Resource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789847376 , 9781789847369 , 9781789859256
    Language: English
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches
    Note: English
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  • 23
    Online Resource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789840889 , 9781789840872 , 9781838819705
    Language: English
    Pages: 1 Online-Ressource (96 p.)
    Keywords: Medical genetics
    Abstract: Epigenetic changes are heritable and reversible modifications that significantly affect gene expression without any change in DNA sequence. The epigenetic signature is remodelled during the lifespan as a direct consequence of both environment and lifestyle. Therefore, health or disease status strongly depends on epigenetic marks. This book summarizes the current knowledge in the field and includes chapters on epigenetics in plants and epigenetics in health and disease. It is written for a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding of epigenetics
    Note: English
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  • 24
    Online Resource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789844276 , 9781789844269 , 9781838819743
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Medical genetics
    Abstract: Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment
    Note: English
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  • 25
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789845099 , 9781789845082 , 9781838806897
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed
    Note: English
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  • 26
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789843286 , 9781789843279 , 9781789852639
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Keywords: Medical genetics
    Abstract: Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analysis is most commonly used to compare specific pairs of samples, for example, tumor tissue versus its healthy counterpart. In this volume, Dr. Pyo Hong discusses the role of long RNA sequences in transcriptome analysis, Dr. Shinichi describes the next-generation single-cell sequencing technology developed by his team, Dr. Prasanta presents transcriptome analysis applied to rice under various environmental factors, Dr. Xiangyuan addresses the reproductive systems of flowering plants and Dr. Sadovsky compares codon usage in conifers
    Note: English
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  • 27
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789853766 , 9781789853759 , 9781839620461
    Language: English
    Pages: 1 Online-Ressource (64 p.)
    Keywords: Medical genetics
    Abstract: Animal genetics is a field of science with important theoretical and practical significance in finding the answers for the actual problems of mankind. We hope that the readers will discover some new facts regarding the relationship between plasma proteins and boar semen freezability, the importance of some behavioral factors that affect reproduction in horses, and also an important chapter regarding the use of genetically modified organisms for the repopulation of species of commercial importance in aquatic environments, their effect on the genetic pool, risks to protected areas, and policies for their proper management
    Note: English
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  • 28
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789856842 , 9781789856835 , 9781839620799
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medical genetics
    Abstract: Genes store life data and information in genetic language. In accordance with the Central Dogma, life data are located in DNA sequences in the format of genes and the information is transcribed into transient molecules of RNA and finally the coding RNAs are translated into proteins. But the role of RNAs is pivotal. In other words, gene regulation (including expression or suppression) is an amazing and vital process that is composed of two central networks; DNAs and RNAs. Today, the principal and fundamental role of RNA molecules is revealed and it is known that the regulation of genes is directly controlled by DNA and RNA molecules. The diversity of RNAs in different cells and in particular Eukaryotic cells explains the importance of RNAs in gene regulation
    Note: English
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  • 29
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838811921 , 9781838811914 , 9781838811938
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Knowledge of the structure and function of the complex and interwoven network of nerves is inexhaustible and has not been fully determined. The physiological basis of many neuropathic symptoms continues to pursue experts in this field, and in many of the pathological changes related to neuropathies. In the last few decades, there has been increasing interest in new tools applied to diseases involving nerves of the nervous system, which have changed this state of affairs. Microscopic studies, new quantitative histometric methods, and refined physiologic techniques have already expanded our knowledge of structure and function of nerves and rapidly advancing techniques in the fields of immunology and molecular genetics to clarify entire categories of polyneuropathy. Although polyneuropathy is among the most challenging categories of neurological diseases, effective forms of treatment for polyneuropathy have been introduced during the last few decades. This book intends to provide the reader with a broad overview of polyneuropathy, featuring considerations and diagnostic approaches to patients, specific neuropathic syndromes and new related entities, pathogenic mechanisms, and pathological reactions brought to bear to the therapeutic and new clinical applications. All this is important evidence to support present and future directions in this challenging topic
    Note: English
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  • 30
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789857788 , 9781789857771 , 9781839620898
    Language: English
    Pages: 1 Online-Ressource (70 p.)
    Keywords: Medical genetics
    Abstract: Population genetics is the basis of evolutionary studies, and has been widely used in several researches. This recent field of science has important applications for the management of populations (natural and domesticated), as well as for evolutionary studies of the various factors that affect gene frequencies over time and spatial distribution.In this work, presented in three sections (Population and Quantitative Genetics, Genetic Diversity in Crop Management, Population Genetics for Conservation Studies), the reader will find cutting-edge information in carefully selected and revised works.This book is intended for all researchers, academics, and students who are interested in the intriguing area of population genetics
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  • 31
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    ISBN: 9781839681431 , 9781839681424 , 9781839681448
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Keywords: Medical genetics
    Abstract: The field of medical genetics and genomics has been constantly revolutionized by new breakthroughs, which bring more knowledge into the etiology and help improve the health care of individuals with either rare or common diseases. Nevertheless, as technologies evolve, novel challenges emerge, both technically and ethically, so they must be prudentially addressed. Among the myriad applications of genomics in medicine, this book depicts a glimpse of the advances achieved that have been leading us to the personalized/precision medicine era
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  • 32
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    ISBN: 9781789845334 , 9781789845327 , 9781789852653
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Keywords: Medical genetics
    Abstract: Antisense Therapy offers a comprehensive, state-of-the art perspective on the role of antisense therapy in the treatment of human disease, with a special focus on cancer. Use of antisense oligonucleotides is a growing field of pharmaceutical and biotech companies and research programs for treatment of several diseases. This book summarizes and presents the best updates, therapeutic principles, methods, and applications in the field and offers meaningful information to move treatment discovery forward
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  • 33
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    ISBN: 9781789238266 , 9781789238259 , 9781789843712
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Series Statement: Physiology 6
    Keywords: Neurology & clinical neurophysiology
    Abstract: Nowadays, neurodevelopmental disorders comprise a large proportion of mental health diagnoses. These disorders, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, include intellectual disabilities, communication disorders, autism spectrum disorders, attention deficit hyperactivity disorders, specific learning disorders, and motor disorders. Current research is pointing in the direction of schizophrenia, bipolar disorders, and other disorders being included in the category of neurodevelopmental disorders as well. There is a great deal of overlap among these disorders and they are best understood in a dimensional fashion. This book sets out the future of psychiatry in relation to these disorders and what is basically a new understanding of psychiatry in recent decades. Chapters cover topics such as early recognition of schizophrenia, epilepsy, and the genetics of ataxia telangiectasia. Also included is an examination of the complex issue of systems biology and neurodevelopment
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  • 34
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    ISBN: 9781838812348 , 9781838812331 , 9781838812355
    Language: English
    Pages: 1 Online-Ressource (100 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: This Edited Volume Recent Advances in Neurodegeneration is a is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of neurodegeneration. The book comprises single chapters authored by various researchers and edited by an expert active in the neurodegeneration research area. All chapters are complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on neurodegeneration, and open new possible research paths for further novel developments
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  • 35
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    ISBN: 9781789238686 , 9781789238679 , 9781839625701
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Epilepsy is the most common neurological disorder globally, affecting approximately 50 million people of all ages. It is one of the oldest diseases described in literature from remote ancient civilizations 2000-3000 years ago. Despite its long history and wide spread, epilepsy is still surrounded by myth and prejudice, which can only be overcome with great difficulty. The term epilepsy is derived from the Greek verb epilambanein, which by itself means to be seized and to be overwhelmed by surprise or attack. Therefore, epilepsy is a condition of getting over, seized, or attacked. The twelve very interesting chapters of this book cover various aspects of epileptology from the history and milestones of epilepsy as a disease entity, to the most recent advances in understanding and diagnosing epilepsy
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  • 36
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    ISBN: 9781789844153 , 9781789844146 , 9781838817442
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: The book contains four chapters discussing dystonia from a new perspective. Dystonia may result from either diffuse or localized pathology of the cerebral cortex, brain stem, or spinal cord. Management of dystonia is challenging, and specific goals should be identified. Dystonia is considered one of the most disabling conditions in the pediatric age group, which may remain until adulthood; treatment is usually unsatisfactory. Meige's syndrome, or "oromandibular dystonia," may be misdiagnosed as temporomandibular joint or psychogenic disorder, which will alter management and delay proper treatment. Dystonia with non-motor disorders includes sleep, cognitive, pain, sensory, and psychiatric disorders, and their pathophysiological and biochemical mechanisms and specific treatment are discussed. This book will be of interest to GPs, neurologists, family physicians, and internal medicine specialists
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  • 37
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    ISBN: 9789535125693 , 9789535125686 , 9789535154488
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Medical genetics
    Abstract: Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation
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  • 38
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    ISBN: 9789535126577 , 9789535126560 , 9789535173106
    Language: English
    Pages: 1 Online-Ressource (338 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease characterized by progressive demyelination and neurodegeneration of the central nervous system (CNS), constituting the most common demyelinating disease of the CNS in humans. Although intensive research over many decades has unveiled many pathophysiological mechanisms in the development of MS, the cause is still unknown. Nevertheless, it does seem clear that genetic susceptibility and environmental factors play crucial roles. Trending Topics in Multiple Sclerosis is a book that provides an insight into some of the main problems currently debated in this area of research, focusing on topics that deal with genetic and environmental risk factors, pathophysiological mechanisms, neurocognitive findings, and neuroprotective strategies
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  • 39
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    ISBN: 9789535125518 , 9789535125501 , 9789535154457
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medical genetics
    Abstract: Flow cytometry - Select Topics is a collection of chapters that illustrate the constantly evolving application of flow cytometry to diverse areas of research or clinical investigations. It includes chapters on the utilization of flow cytometry in the fields of human reproduction and fertility, platelet function, apoptosis, inflammation research, leukemia immunophenotyping, and transplantation
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  • 40
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    ISBN: 9789535122401 , 9789535154198
    Language: English
    Pages: 1 Online-Ressource (464 p.)
    Keywords: Medical genetics
    Abstract: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences
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  • 41
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    ISBN: 9789535124641 , 9789535124634 , 9789535172918
    Language: English
    Pages: 1 Online-Ressource (400 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Parkinson's disease is a common neurological disease and affects 2% population of more than 65 years of age and 5% more than 85 years of age. Pathomechanism of this disease is still not fully understood. This book is a sum up of knowledge on the genetic factors and neuronal death mechanisms induced by excitotoxic and inflammatory agents. The authors summarize the pathophysiology observed both in patients with Parkinson's disease and in experimental models. The book also contains the latest views on drug therapy used in the treatment of parkinsonism and other therapeutic approaches for Parkinson's disease. The book ''Challenges in Parkinson's Disease'' was made as a compendium on contemporary challenges in Parkinson's disease
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  • 42
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    ISBN: 9789535124566 , 9789535124559 , 9789535154402
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Medical genetics
    Abstract: Plant genomics aims to sequence, characterize, and study the genetic compositions, structures, organizations, functions, and interactions/networks of an entire plant genome. Its development and advances are tightly interconnected with proteomics, metabolomics, metagenomics, transgenomics, genomic selection, bioinformatics, epigenomics, phenomics, system biology, modern instrumentation, and robotics sciences. Plant genomics has significantly advanced over the past three decades in the land of inexpensive, high-throughput sequencing technologies and fully sequenced over 100 plant genomes. These advances have broad implications in every aspect of plant biology and breeding, powered with novel genomic selection and manipulation tools while generating many grand challenges and tasks ahead. This Plant genomics provides some updated discussions on current advances, challenges, and future perspectives of plant genome studies and applications
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  • 43
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    ISBN: 9789535126492 , 9789535126485 , 9789535173120
    Language: English
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Nowadays, cerebral palsy (CP) rehabilitation, along with medical and surgical interventions in children with CP, leads to better motor and postural control and can ensure ambulation and functional independence. In achieving these improvements, many modern practices may be used, such as comprehensive multidisciplinary assessment, clinical decision making, multilevel surgery, botulinum toxin applications, robotic ambulation applications, treadmill, and other walking aids to increase the quality and endurance of walking. Trainings are based on neurodevelopmental therapy, muscle training and strength applications, adaptive equipment and orthotics, communication, technological solves, and many others beyond the scope of this book. In the years of clinical and academic experiences, children with cerebral palsy have shown us that the world needs a book to give clinical knowledge to health professionals regarding these important issue. This book is an attempt to fulfill and to give “current steps” about CP. The book is intended for use by physicians, therapists, and allied health professionals who treat/rehabilitate children with CP. We focus on the recent concepts in the treatment of body and structure problems and describe the associated disability, providing suggestions for further reading. All authors presented the most frequently used and accepted treatment methods with scientifically proven efficacy and included references at the end of each chapter
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  • 44
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    ISBN: 9789535122722 , 9789535146148 , 9789535154297
    Language: English
    Pages: 1 Online-Ressource (458 p.)
    Keywords: Medical genetics
    Abstract: RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment
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  • 45
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    ISBN: 9789535121374 , 9789535172420
    Language: English
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease
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  • 46
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    ISBN: 9789535121527 , 9789535172482
    Language: English
    Pages: 1 Online-Ressource (392 p.)
    Keywords: Medical genetics
    Abstract: Cystic Fibrosis in the Light of New Research provides the latest research and clinical evidence that will be useful for clinicians, scientists and researchers to further their knowledge around this fascinating condition. The authors have brought along their expertise and wealth of knowledge to produce this book, including the basic science that underlies the disease, the burden of bacterial and viral infections, immunologic aspects of CF, a variety of clinical measurements to predict prognosis and novel therapies including gene therapy. This book will be invaluable and entertaining for anyone who is involved in the care of patients with cystic fibrosis
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  • 47
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    ISBN: 9789535121541 , 9789535172529
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: This book provides a concise yet comprehensive source of current information on Down syndrome. It focuses on exciting areas of research on diseases associated with Down syndrome. Inside, you will find state-of-the-art information on diseases associated with Down syndrome; improvement of cognitive skills in Down syndrome; and research approaches on Down syndrome. Although aimed primarily at research workers on Down syndrome, we hope that the appeal of this book extends beyond the narrow confines of academic interest and reaches a wider audience, especially parents, relatives, and health care providers who work with infants and children with Down syndrome
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  • 48
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    ISBN: 9789535121855 , 9789535154099
    Language: English
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medical genetics
    Abstract: The world has come to understand only recently the importance of plants in our life. Therefore, we have brought together such book chapters that will help strengthen the scientific background of the readers on plants and deliver the message regarding plants for the future, in food security, health, industry, and other areas. This book will add to the scientific knowledge of the readers on the molecular aspects of plants
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  • 49
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    ISBN: 9789535122210 , 9789535172680
    Language: English
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medical genetics
    Abstract: Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression
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  • 50
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    ISBN: 9789535113638 , 9789535153917
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medical genetics
    Abstract: The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current understanding of the potential etiologies of Autism Spectrum Disorders. Additional chapters are devoted to DNA methylation, genomic imprinting and human reproduction. A discussion of the role of the epigenome in cancer prevention and polyphenols is also included. Authors provide research findings from both human data and animal model studies. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of epigenetics and epigenomics
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  • 51
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    ISBN: 9789535113836 , 9789535172086
    Language: English
    Pages: 1 Online-Ressource (428 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Pharmacology and Nutritional Intervention in the Treatment of Disease is a book dealing with an important research field that has worldwide significance. Its aim is to strengthen the research base of this field of investigation as it yields knowledge that has important implications for biomedicine, public health and biotechnology. The book has brought together an interdisciplinary group of contributors and prominent scholars from different parts of the world. The basic purpose of this book was to promote interaction and discussion of problems of mutual interests among people in related fields everywhere. The main subjects of the book include nutrition, mechanisms underlying treatments, physiological aspects of vitamins and trace elements, antioxidants: regulation, signalling, infection and inflammation, and degenerative and chronic diseases
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  • 52
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    ISBN: 9789535112297 , 9789535171980
    Language: English
    Pages: 1 Online-Ressource (232 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert
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  • 53
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    ISBN: 9789535109198 , 9789535170624
    Language: English
    Pages: 1 Online-Ressource (418 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: This book brings together an international array of stars of the mental health professions to create a cutting edge volume that sheds light on many important and heretofore poorly understood issues in psychopathology. Mental Disorders-Theoretical and Empirical perspectives will be an important addition to the libraries of scholars and clinicians
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  • 54
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    ISBN: 9789535109914 , 9789535153573
    Language: English
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Medical genetics
    Abstract: DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations
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  • 55
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    ISBN: 9789535109976 , 9789535153580
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medical genetics
    Abstract: Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions
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  • 56
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    ISBN: 9789535110873 , 9789535153672
    Language: English
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medical genetics
    Abstract: The term "chromatin remodelling" is widely used to describe changes in chromatin structure which is controlled by histone-modifying enzymes, chromatin remodelling complexes, non-histone DNA-binding proteins and noncoding RNAs. Many human diseases such as cancer, various genetic syndromes, autism and infectious disease have been linked to the disruption of these control processes by genetic, environmental or microbial factors. Therefore, to unravel the mechanisms by which they operate is one of the most exciting and rapid developing fields of modern biology and will contribute to new ways in treatment of these diseases. The chapters in this book will focus on recent advances in our understanding of the mechanisms that govern the dynamic structural of chromatin, thereby providing important insights into gene regulation, DNA repair, and human diseases
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  • 57
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    ISBN: 9789535110972 , 9789535153689
    Language: English
    Pages: 1 Online-Ressource (396 p.)
    Keywords: Medical genetics
    Abstract: Current Progress in Biological Research presents new insights into key topics from different areas of the biological sciences. Some of the topics covered in the book are antibiotic susceptibility, genomic rearrangement, historical biogeography, biogeographic patterns, endemism and the use of microorganisms for pest control. The book is an interesting collection of 16 original research articles written by respected experts in their fields. It is hoped that readers will be stimulated and challenged by the contents of this book
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  • 58
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    ISBN: 9789535109945 , 9789535153528
    Language: English
    Pages: 1 Online-Ressource (464 p.)
    Keywords: Medical genetics
    Abstract: This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research
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  • 59
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    ISBN: 9789535109662 , 9789535170853
    Language: English
    Pages: 1 Online-Ressource (406 p.)
    Keywords: Medical genetics
    Abstract: Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancer
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  • 60
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    ISBN: 9789535110361 , 9789535171102
    Language: English
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Medical genetics
    Abstract: Down syndrome, the most cutting-edge book in the field congenital disorders. This book features up-to-date, well referenced research and review articles on Down syndrome. Research workers, scientists, medical graduates and pediatricians will find it to be an excellent source for references and review. It is hoped that such individuals will view this book as a resource that can be consulted during all stages of their research and clinical investigations. Key features of this book are: Common diseases in Down syndrome Molecular Genetics Neurological Disorders Prenatal Diagnosis and Genetic Counselling Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents, relatives and health-care providers who work with infants and children with Down syndrome
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    ISBN: 9789535111955 , 9789535171799
    Language: English
    Pages: 1 Online-Ressource (266 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions
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  • 62
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    ISBN: 9789535111979 , 9789535153856
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medical genetics
    Abstract: Meiosis is the key process underlying sexual reproduction in eukaryotes, occurring in single-celled eukaryotes and in most multicellular eukaryotes including animals and most plants. Thus meiosis is of considerable interest, both at the scientific level and at the level of natural human curiosity about sexual reproduction. Improved understanding of important aspects of meiosis has emerged in recent years and major questions are starting to be answered, such as: How does meiosis occur at the molecular level, How did meiosis and sex arise during evolution, What is the major adaptive function of meiosis and sex. In addition, changing perspectives on meiosis and sex have led to the question: How should meiosis be taught. This book proposes answers to these questions, with extensive supporting references to the current literature
    Note: English
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  • 63
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    ISBN: 9789535111146 , 9789535153757
    Language: English
    Pages: 1 Online-Ressource (674 p.)
    Keywords: Medical genetics
    Abstract: This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair
    Note: English
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  • 64
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    ISBN: 9789535110149 , 9789535153627
    Language: English
    Pages: 1 Online-Ressource (756 p.)
    Keywords: Medical genetics
    Abstract: The Gene Therapy field is living exciting times after more than 20 years of poor results. Scientist and clinicians working in the gene therapy field have encountered many problems in the past that are now starting to be solved. The development of safer and more efficient gene transfer vectors and the advances on the cell therapy field have open new opportunities to tackle different diseases. The aim of this book is to bring together information about the different gene therapy tools, the clinical successes of gene therapy and the future applications
    Note: English
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  • 65
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    ISBN: 9789535110095 , 9789535171003
    Language: English
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Alzheimer's dementia (AD) affects 6 million Europeans with 10% of people over age 65 and more than a quarter over 85. Given the steady aging of European societies, dementia and cognitive decline have developed into a major health problem with an enormous socioeconomic impact for patients, their families and caregivers, national health care systems, and society. Without any means to prevent or delay disease onset, the number of people with dementia is predicted to double by 2030 and triple by 2050. There is an urgent need for innovative strategies to increase understanding of pathological events that would translate into the development of successful prevention or, possibly, novel treatment strategies. Progresses in understanding pathological events in AD have been possible by using cell cultures, genetically modified organisms and animal models that lack the complexity of events occurring in humans. We need to overcome this limitation also by using data from humans - for studying pathological pathways in AD in a multidisciplinary setting
    Note: English
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  • 66
    ISBN: 9789535110606 , 9789535171201
    Language: English
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Understanding the rapid changes in the evaluation and management of peripheral neuropathies, as well as the complexity of their mechanism, is a mandatory requirement for the practitioner to optimize patient's care. The objective of this book is to update health care professionals on recent advances in the pathogenesis, diagnosis and treatment of peripheral neuropathy. This work was written by a group of clinicians and scientists with large expertise in the field
    Note: English
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  • 67
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    ISBN: 9789535109594 , 9789535170709
    Language: English
    Pages: 1 Online-Ressource (298 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Mood disorders are a crucial group of mental disorders that last for a life time, cause psychosocial dysfunction, disrupts interpersonal relationships and are overall highly restrictive. The facts that mood disorders are seen as high as 3-5% of the society and 70% of the patients' first psychiatric application puts forward that they are not well known show that these are a serious type of mental illness. The average time to make the right diagnose is reported as 10 years. The delays in diagnose and beginning of treatment lays a heavy burden on the patient, their relatives and society in general. After the diagnose begins the process of selecting the right treatment method of each individual which is of high importance as to enable the patient go through their treatment period without mental exhaustion. Protecting treatment planning and management in long term treatments are significant for the control of the disorder. Difficulties are frequently experience during diagnose, treatment and follow up for mood disorders. Professional constantly seek for innovations to resolve these issues in treating mood disorders. In this context, we hope that this book will become an important resource of some new researches for clinicians
    Note: English
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  • 68
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    ISBN: 9789535110286 , 9789535171140
    Language: English
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medical genetics
    Abstract: Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity
    Note: English
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  • 69
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    ISBN: 9789535110880 , 9789535171461
    Language: English
    Pages: 1 Online-Ressource (640 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking
    Note: English
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  • 70
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    ISBN: 9789535108863 , 9789535170617
    Language: English
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medical genetics
    Abstract: Human genetics is the medical field with the most rapid progress. This book aims to provide an overview on some of the latest developments in several genetic diseases. It contains 14 chapters focused on various genetic disorders addressing epidemiology, etiology, molecular basis and novel treatment options for these diseases. The chapters were written by 41 collaborators, from 8 different countries in Europe, Asia, and America, with great expertise in their field. Chapters are heterogeneous, offering a welcomed personalized view on each particular subject. The book does not offer a systematic overview of human genetic disorders. However, they are a valuable resource for medical practitioners, researchers, biologists and students in various medical sciences
    Note: English
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  • 71
    ISBN: 9789535106937 , 9789535170204
    Language: English
    Pages: 1 Online-Ressource (404 p.)
    Keywords: Medical genetics
    Abstract: Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases
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  • 72
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    ISBN: 9789535106036 , 9789535169949
    Language: English
    Pages: 1 Online-Ressource (556 p.)
    Keywords: Medical genetics
    Abstract: With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders. This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. This book discusses the currently available diagnostic approaches that have revolutionized clinical research. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed. Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies
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  • 73
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    ISBN: 9789535103318 , 9789535152507
    Language: English
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medical genetics
    Abstract: This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world
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  • 74
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    ISBN: 9789533078656 , 9789535167334
    Language: English
    Pages: 1 Online-Ressource (406 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Intellectual and Developmental Disabilities presents reports on a wide range of areas in the field of neurological and intellectual disability, including habitual human quadrupedal locomotion with associated cognitive disabilities, Fragile X syndrome, autism spectrum disorders, Down syndrome, and intellectual developmental disability among children in an African setting. Studies are presented from researchers around the world, looking at aspects as wide-ranging as the genetics behind the conditions to new and innovative therapeutic approaches
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  • 75
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    ISBN: 9789535107019 , 9789535153115
    Language: English
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medical genetics
    Abstract: This book looks at the latest research studies on apoptosis in medicine. It is divided into three sections for convenient and easy reading. The first section which comprises two chapters is an introduction of the subject of apoptosis to the uninitiated. The second section which comprises a single solitary chapter looks at apoptosis in normal physiology during bone resorption under mechanical stress. The third and the final section reviews apoptosis in a number of pathological conditions with an emphasis on cancer
    Note: English
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  • 76
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    ISBN: 9789535105428 , 9789535169772
    Language: English
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medical genetics
    Abstract: The purpose of this book has been to depict as many biochemical, genetic and molecular advances as possible, in the vast field of the spinocerebellar ataxias
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  • 77
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    ISBN: 9789535100799 , 9789535152132
    Language: English
    Pages: 1 Online-Ressource (384 p.)
    Keywords: Medical genetics
    Abstract: In a classical approach materials science is mainly dealing with interatomic interactions within molecules, without paying much interest on weak intermolecular interactions. However, the variety of structures actually is the result of weak ordering because of noncovalent interactions. Indeed, for self-assembly to be possible in soft materials, it is evident that forces between molecules must be much weaker than covalent bonds between the atoms of a molecule. The weak intermolecular interactions responsible for molecular ordering in soft materials include hydrogen bonds, coordination bonds in ligands and complexes, ionic and dipolar interactions, van der Waals forces, and hydrophobic interactions. Recent evolutions in nanosciences and nanotechnologies provide strong arguments to support the opportunity and importance of the topics approached in this book, the fundamental and applicative aspects related to molecular interactions being of large interest in both research and innovative environments. We expect this book to have a strong impact at various education and research training levels, for young and experienced researchers from both academia and industry
    Note: English
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  • 78
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    ISBN: 9789535108818 , 9789535153412
    Language: English
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Medical genetics
    Abstract: Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain
    Note: English
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  • 79
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    ISBN: 9789535108061 , 9789535153320
    Language: English
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Including some of the newest advances in the field of neurophysiology, this book can be considered as one of the treasures that interested scientists would like to collect. It discusses many disciplines of clinical neurophysiology that are, currently, crucial in the practice as they explain methods and findings of techniques that help to improve diagnosis and to ensure better treatment. While trying to rely on evidence-based facts, this book presents some new ideas to be applied and tested in the clinical practice. Advances in Clinical Neurophysiology is important not only for the neurophysiologists but also for clinicians interested or working in wide range of specialties such as neurology, neurosurgery, intensive care units, pediatrics and so on. Generally, this book is written and designed to all those involved in, interpreting or requesting neurophysiologic tests
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  • 80
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    ISBN: 9789535105886 , 9789535169895
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Medical genetics
    Abstract: This book deals with central concepts in population genetics, describing the main evolutionary processes that influence the allele frequency distribution and change. The different chapters discuss topics such as population size and structure, migration, inbreeding and interbreeding, mechanisms of extinction and speciation, along with different data techniques and molecular methods used for detecting DNA sequence variation in the study of genetic polymorphisms. Part of the book includes statistical and computational methods commonly used to process population genetics data, which constitute an essential tool for understanding the concepts discussed. The book will be a useful reference for graduate students and researchers working on population genetics, and other related areas including microbiology, genetics, molecular biology, ecology, anthropology and others
    Note: English
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  • 81
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    ISBN: 9789535106173 , 9789535152996
    Language: English
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: If one asks what neuroscience is, the answer can be found in this book. Neuroscience embraces not only anatomical and physiological studies but also cell biology, computer science, and biochemistry. Equally important for neuroscientific research are other disciplines, such as psychology, psychiatry, neurology and additional recent ones, such as neuroeconomics and social neuroscience. This book comprises chapters on diverse topics in neuroscience ranging from cellular, computational, cognitive, and clinical neuroscience. Individual chapters focus on recent advances in specific areas including social neuroscience, which is a relatively new field that studies the neural basis of social interactions. Other chapters focus on technological developments such as optical tools to study the function of the brain. All chapters represent recent contributions to the rapidly developing field of neuroscience and illustrate the range of research conducted under the umbrella of the truly interdisciplinary neurosciences
    Note: English
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  • 82
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    ISBN: 9789535104070 , 9789535169345
    Language: English
    Pages: 1 Online-Ressource (290 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Peripheral nerve disorders are comprising one of the major clinical topics in neuromusculoskeletal disorders. Sharp nerve injuries, chronic entrapment syndromes, and peripheral neuropathic processes can be classified in this common medical topic. Different aspects of these disorders including anatomy, physiology, pathophysiology, injury mechanisms, and different diagnostic and management methods need to be addressed when discussing this topic. The goal of preparing this book was to gather such pertinent chapters to cover these aspects
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  • 83
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    [Erscheinungsort nicht ermittelbar] : IntechOpen | Rijeka : IntechOpen
    ISBN: 9789535152002
    Language: English
    Pages: 1 Online-Ressource (XII, 236 Seiten)
    Keywords: Neurology & clinical neurophysiology ; Aufsatzsammlung
    Abstract: Despite significant technological advances in recent years, their impact on our overall health and social, well-being is not always clear to see. Perhaps, one of the best examples of this can be highlighted by the fact that mortality rates as a result of cerebrovascular diseases have hardly changed, if at all. This places cerebrovascular diseases as one of the most prominent causes of both disability and death. In Cuba, for instance, a total of 22,000 cases of cerebrovascular diseases are reported each year in a country where life expectancy should increase to 80 years in the near future. In such a situation, to have a book that includes in a clear and summarized way, a group of topics directly related to the preclinical investigations advances and the therapeutic procedures for the cerebrovascular disease in its acute phase constitutes a useful tool for the wide range of the contributors to this affection's problems solution. In this group is included students, professors, researchers, and health policy makers whose work represents one of the greatest social and human impact challenges of the XXI century basic and clinical neurosciences
    Note: Literaturangaben , English
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  • 84
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    ISBN: 9789535107583 , 9789535153191
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Medical genetics
    Abstract: Proteins are essential for all cellular events. They bind or interact with additional players such as other proteins, peptides, DNA, and RNA to exert their functions. Revealing protein binding partners is important in understanding the mechanisms through which they function in the cells and the organism. These interactions are essential in the regulation of cell fates and could be important in drugs development. For example proteins can bind mRNA to regulate stability and translation. They also bind other proteins for degradation or proteolysis. These mRNAs and proteins could be involved in cellular processes such as cell survival or apoptosis. This book contains review articles dealing with protein interactions with the above mentioned factors. The enclosed articles could be informative and stimulating for readers interested in protein binding partners and the consequences of such interactions
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  • 85
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    ISBN: 9789535101185 , 9789535152187
    Language: English
    Pages: 1 Online-Ressource (474 p.)
    Keywords: Medical genetics
    Abstract: Meiosis, the process of forming gametes in preparation for sexual reproduction, has long been a focus of intense study. Meiosis has been studied at the cytological, genetic, molecular and cellular levels. Studies in model systems have revealed common underlying mechanisms while in parallel, studies in diverse organisms have revealed the incredible variation in meiotic mechanisms. This book brings together many of the diverse strands of investigation into this fascinating and challenging field of biology
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  • 86
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    ISBN: 9789535103202 , 9789535152446
    Language: English
    Pages: 1 Online-Ressource (402 p.)
    Keywords: Medical genetics
    Abstract: Epigenetics is one of the most exciting and rapidly developing areas of modern genetics with applications in many disciplines from medicine to agriculture. The most common form of epigenetic modification is DNA methylation, which plays a key role in fundamental developmental processes such as embryogenesis and also in the response of organisms to a wide range of environmental stimuli. Indeed, epigenetics is increasing regarded as one of the major mechanisms used by animals and plants to modulate their genome and its expression to adapt to a wide range of environmental factors. This book brings together a group of experts at the cutting edge of research into DNA methylation and highlights recent advances in methodology and knowledge of underlying mechanisms of this most important of genetic processes. The reader will gain an understanding of the impact, significance and recent advances within the field of epigenetics with a focus on DNA methylation
    Note: English
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  • 87
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    ISBN: 9789533078762 , 9789535167419
    Language: English
    Pages: 1 Online-Ressource (606 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process
    Note: English
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  • 88
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    ISBN: 9789535106081 , 9789535152965
    Language: English
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Medical genetics
    Abstract: Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies
    Note: English
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  • 89
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    ISBN: 9789535105022 , 9789535169611
    Language: English
    Pages: 1 Online-Ressource (376 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Currently, the human population is on a collision course for a social and economic burden. As a consequence of changing demographics and an increase in human individuals over the age of 60, age-related neurodegenerative disorders are likely to become more prevalent. It is therefore essential to increase our understanding of such neurodegenerative disorders in order to be more pro-active in managing these diseases processes. The focus of this book is to provide a snapshot of recent advancements in the understanding of basic biological processes that modulate the onset and progression of neurodegenerative processes. This is tackled at the molecular, cellular and whole organism level. We hope that some of the recent discoveries outlined in this book will help to better define the basic biological mechanisms behind neurodegenerative processes and, in the long term, help in the development of novel therapeutic approaches
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  • 90
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    ISBN: 9789535105640 , 9789535152804
    Language: English
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medical genetics
    Abstract: This book illustrates methods of DNA sequencing and its application in plant, animal and medical sciences. It has two distinct sections. The one includes 2 chapters devoted to the DNA sequencing methods and the second includes 6 chapters focusing on various applications of this technology. The content of the articles presented in the book is guided by the knowledge and experience of the contributing authors. This book is intended to serve as an important resource and review to the researchers in the field of DNA sequencing
    Note: English
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  • 91
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    ISBN: 9789535108498 , 9789535153399
    Language: English
    Pages: 1 Online-Ressource (306 p.)
    Keywords: Medical genetics
    Abstract: Telomeres, located at the ends of linear chromosomes, are essential for genome stability and integrity. Advances in telomere researches have linked telomere dysfunction with cellular aging and a number of age-related human diseases. Recent studies further expanded our knowledge of telomere functions - telomeres are shown to be important for microbial pathogen virulence and telomere proteins have important non-telomeric cellular functions. This book includes current opinions on selected aspects of telomere research and their implication, in hope to help us focus better on future studies and enhance our research progress
    Note: English
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  • 92
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    ISBN: 9789535105756 , 9789535152958
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Medical genetics
    Abstract: "Clinical Flow Cytometry - Emerging Applications" contains a collection of reviews and original papers that illustrate the relevance of flow cytometry for the study of specific diseases and clinical evaluations. The chapters have been contributed by authors from a wide variety of countries showing the broad application and importance of this technology in medicine. Examples include chapters on autoimmune disease, cancer, and the evaluation of new drugs. The book is intended to give newcomers a helpful introduction, but also to provide experienced flow cytometrists with novel insights and a better understanding of clinical cytometry
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  • 93
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    ISBN: 9789535107279 , 9789535153160
    Language: English
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medical genetics
    Abstract: This book titled "Functional Genomics" contains a selection of chapters focused on crucial topics in functional genomics, from the analysis of the genetic code, to the understanding of the role of the different genes and to the proteomic implications. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Covering all the aspects involved in such a broad theme as functional genomics and in all its applications would be impossible within the same book. The different chapters represent a brief introduction to the topic, connecting the most promising developments in functional genomics technologies, focusing on specific applications in biomedicine, agro-food technologies and zootechniques
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  • 94
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    ISBN: 9789535106265 , 9789535153030
    Language: English
    Pages: 1 Online-Ressource (512 p.)
    Keywords: Medical genetics
    Abstract: "Flow Cytometry - Recent Perspectives" is a compendium of comprehensive reviews and original scientific papers. The contents illustrate the constantly evolving application of flow cytometry to a multitude of scientific fields and technologies as well as its broad use as demonstrated by the international composition of the contributing author group. The book focuses on the utilization of the technology in basic sciences and covers such diverse areas as marine and plant biology, microbiology, immunology, and biotechnology. It is hoped that it will give novices a valuable introduction to the field, but will also provide experienced flow cytometrists with novel insights and a better understanding of the subject
    Note: English
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  • 95
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535101444 , 9789535143406
    Language: English
    Pages: 1 Online-Ressource (864 p.)
    Keywords: Medical genetics
    Abstract: The book "Senescence" is aimed to describe all the phenomena related to aging and senescence of all forms of life on Earth, i.e. plants, animals and the human beings. The book contains 36 carefully reviewed chapters written by different authors, aiming to describe the aging and senescent changes of living creatures, i.e. plants and animals
    Note: English
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  • 96
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535100935 , 9789535152149
    Language: English
    Pages: 1 Online-Ressource (374 p.)
    Keywords: Medical genetics
    Abstract: Analysis of Genetic Variation in Animals includes chapters revealing the magnitude of genetic variation existing in animal populations. The genetic diversity between and within populations displayed by molecular markers receive extensive interest due to the usefulness of this information in breeding and conservation programs. In this concept molecular markers give valuable information. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in animals and also, the detection of genes influencing economically important traits. The purpose of the book is to provide a glimpse into the dynamic process of genetic variation in animals by presenting the thoughts of scientists who are engaged in the generation of new idea and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of conservation biology, genetic diversity, and molecular biology
    Note: English
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  • 97
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535101789 , 9789535152231
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Keywords: Medical genetics
    Abstract: Recent Trends in Cytogenetic Studies - Methodologies and Applications deals with recent trends in cytogenetics with minute details of methodologies that can be adopted in clinical laboratories. The chapters deal with basic methods of primary cultures, cell lines and their applications; microtechnologies and automations; array CGH for the diagnosis of fetal conditions; approaches to acute lymphoblastic and myeloblastic leukemias in patients and survivors of atomic bomb exposure; use of digital image technology and using chromosomes as tools to discover biodiversity. While concentrating on the advanced methodologies in cytogenetic studies and their applications, authors have pointed out the need to develop cytogenetic labs with modern tools to facilitate precise and effective diagnosis to benefit the patient population
    Note: English
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  • 98
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535106968 , 9789535170211
    Language: English
    Pages: 1 Online-Ressource (284 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Neuromuscular Disorders is an interesting compendium of diverse and fairly inclusive topics in disorders of nerve and muscle, with a spectrum of generally well written and pertinent chapters referencing specific categories of neuromuscular diseases. The expected emphasis on understanding the implications, diagnosis and treatment of the specific muscle and nerve diseases is well done. It contains a basic introductory chapter which is very well-done, and a large range of topics, well-summarized, making it a good reference manual as well as an aid to diagnosis and treatment contained in a relatively small volume. Its accessibility on the internet may make it especially appealing to the younger of us, making it simple to access without necessitating the book's presence in the office
    Note: English
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  • 99
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535103035 , 9789535169024
    Language: English
    Pages: 1 Online-Ressource (256 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: This book presents recent advances in the field of Neurological disorders research. It consists of 9 chapters encompassing a wide range of areas including bioengineering, stem cell transplantation, gene therapy, proteomic analysis, alternative treatment and neuropsychiatry analysis. It highlights the development of multiple discipline approaches in neurological researches. The book brings together leading researchers in neurological disorders and it presents an essential reference for researchers working in the neurological disorders, as well as for students and industrial users who are interested in current developments in neurological researches
    Note: English
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  • 100
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535100669 , 9789535168232
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Neurology & clinical neurophysiology
    Abstract: Over the last two decades we have seen extensive progress within the practice of neurology. We have refined our understanding of the etiology and pathogenesis for both peripheral and central nervous system diseases, and developed new therapeutic approaches towards these diseases. Peripheral neuropathy is a common disorder seen by many specialists and can pose a diagnostic dilemma. Many etiologies, including drugs that are used to treat other diseases, can cause peripheral neuropathy. However, the most common cause is Diabetes Mellitus, a disease all physicians encounter. Disability due to peripheral neuropathy can be severe, as the patients suffer from symptoms daily. This book addresses the advances in the diagnosis and therapies of peripheral neuropathy over the last decade. The basics of different peripheral neuropathies is briefly discussed, however, the book focuses on topics that address new approaches to peripheral neuropathies
    Note: English
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