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  • MPI Ethno. Forsch.  (477)
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  • Undetermined  (477)
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  • Medicine  (477)
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  • MPI Ethno. Forsch.  (477)
  • HBZ
  • MPI-MMG
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  • 1
    Online Resource
    Online Resource
    Autobiographisches Wiedererzählen : Eine interdisziplinäre Studie im qualitativen Längsschnitt (2024)
    Bielefeld : transcript Verlag
    Details
    ISBN: 9783839471906 , 9783837671902
    Language: Undetermined
    Pages: 1 Online-Ressource (364 p.)
    Series Statement: Medical Humanities
    Keywords: Social, group or collective psychology ; Psychoanalytical theory (Freudian psychology) ; Medicine: general issues ; Biographie ; Erzählung ; Lebensgeschichte ; Wiedererzählung ; Interview ; Narratives Interview ; Identität ; Lebensgestaltung ; Medizin ; Therapie ; Krankheit ; Selbsterzählung ; Kultur ; Sprache ; Sozialpsychologie ; Psychoanalyse ; Kulturwissenschaft ; Biography ; Narrative ; Retelling ; Narrative Interview ; Identity ; Life Design ; Medicine ; Therapy ; Illness ; Culture ; Language ; Social Psychology ; Psychoanalysis ; Cultural Studies
    Abstract: Wie erzählen Menschen ihre Lebensgeschichten? Und wie verändern sich diese Erzählungen im Laufe der Zeit? Shevek K. Selbert widmet sich an der Schnittstelle von Biographieforschung, Psychologie und Erzählforschung vollumfänglich wiederholten biographisch-narrativen Interviews, die im Abstand von zehn Jahren geführt wurden. Als Pionierarbeit qualitativer Längsschnittforschung entwickelt er Methoden, um die Erzählversionen miteinander zu vergleichen - und bietet einen einzigartigen Einblick in die Dynamik sowie die (auch therapeutische) Bedeutung von Selbsterzählungen für die Identitätsbildung und die Lebensgestaltung
    Note: German
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  • 2
    Online Resource
    Online Resource
    Soziale Arbeit in der Rehabilitation : Praxis und Wirkmechanismen Sozialer Arbeit in der medizinischen Rehabilitation (2024)
    Bielefeld : transcript Verlag
    Details
    ISBN: 9783839466049 , 9783837666045
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Series Statement: Gesundheit, Kommunikation und Gesellschaft
    Keywords: Social work ; Medicine: general issues ; Soziale Arbeit ; Medizinische Rehabilitation ; Wirkung ; Gesundheit ; Pflege ; Reha ; Zusammenarbeit ; Teilhabe ; Körper ; Medizin ; Sozialarbeit ; Public Health ; Social Work ; Health-related Rehabilitation ; Effect ; Health ; Care ; Cooperation ; Participation ; Body ; Medicine
    Abstract: Soziale Arbeit ist ein wichtiger Teil der medizinischen Rehabilitation. Die Ausgestaltung ihrer Leistungen und ihre potentielle Wirkung blieben bislang allerdings unklar. An dieser Stelle setzen die Autor*innen an und präsentieren die Ergebnisse des Forschungsprojekts SWIMMER: Im Rahmen eines qualitativen Forschungsprojekts wurde die sozialarbeiterische Praxis von Sozialdiensten medizinischer Reha-Einrichtungen untersucht und ein Wirkmodell der Sozialen Arbeit in diesem Bereich entwickelt. Die vergleichende Darstellung der Resultate richtet sich sowohl an Sozialarbeiter*innen als auch an Verantwortliche in den Reha-Einrichtungen, die ihre eigene Praxis reflektieren und einen tieferen Einblick in gängige Arbeitsstrukturen der Sozialdienste erhalten wollen
    Note: German
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  • 3
    Online Resource
    Online Resource
    Artificial Intelligence and Machine Learning in Health Care and Medical Sciences : Best Practices and Pitfalls (2024)
    Cham : Springer Nature
    Details
    ISBN: 9783031393556 , 9783031393549
    Language: Undetermined
    Pages: 1 Online-Ressource (810 p.)
    Series Statement: Health Informatics
    Keywords: Medical equipment and techniques ; Information technology: general topics ; Nursing and ancillary services ; Computer science ; Biology, life sciences ; Public health and preventive medicine ; Predictive analytics ; Artificial intelligence ; Medicine ; Machine learning ; Causal discovery ; Causal inference ; Genomics ; Medical knowledge discovery ; Clinical risk models ; Clinical risk stratification
    Abstract: This open access book provides a detailed review of the latest methods and applications of artificial intelligence (AI) and machine learning (ML) in medicine. With chapters focusing on enabling the reader to develop a thorough understanding of the key concepts in these subject areas along with a range of methods and resulting models that can be utilized to solve healthcare problems, the use of causal and predictive models are comprehensively discussed. Care is taken to systematically describe the concepts to facilitate the reader in developing a thorough conceptual understanding of how different methods and resulting models function and how these relate to their applicability to various issues in health care and medical sciences. Guidance is also given on how to avoid pitfalls that can be encountered on a day-to-day basis and stratify potential clinical risks. Artificial Intelligence and Machine Learning in Health Care and Medical Sciences: Best Practices and Pitfallsis a comprehensive guide to how AI and ML techniques can best be applied in health care. The emphasis placed on how to avoid a variety of pitfalls that can be encountered makes it an indispensable guide for all medical informatics professionals and physicians who utilize these methodologies on a day-to-day basis. Furthermore, this work will be of significant interest to health data scientists, administrators and to students in the health sciences seeking an up-to-date resource on the topic
    Note: English
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  • 4
    Online Resource
    Online Resource
    The 10th International Seminar of Veterinary Medicine : Camelids in Algeria & Maghreb (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574806 , 9783036574813
    Language: Undetermined
    Pages: 1 Online-Ressource (94 p.)
    Keywords: Medicine
    Abstract: This book is a collection of articles focused on recent research covering a species which is emblematic of scientific and commercial interest—the dromedary. The dromedary economy and its sustainability are of a capital importance for the future development of humanity. This research highlights camel productions systems and rearing practices, camel biodiversity and genetics, camel breeding and feeding, dromedary pathologies, anatomy particularities in dromedary, therapeutic virtues of camel products, as well as the industry’s contribution to food security
    Note: English
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  • 5
    Online Resource
    Online Resource
    Dietary Intake and Chronic Disease Prevention (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573090 , 9783036573083
    Language: Undetermined
    Pages: 1 Online-Ressource (292 p.)
    Keywords: Medicine
    Abstract: This reprint describes how lifestyle changes can impact the incidence and progression of chronic non-communicable diseases. In this context, regular physical activity and heathy nutritional habits are very important. Moreover, natural bioactive compounds could represent a new adjuvant therapy in the clinical management of these pathological conditions
    Note: English
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  • 6
    Online Resource
    Online Resource
    Minimally Invasive Urological Procedures and Related Technological Developments—Series 2 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577661 , 9783036577678
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Medicine ; Surgery
    Abstract: We are in the modern era of innovations, technological developments and minimisation in the field of urology. While laparoscopy and robotic surgery have revolutionised pelvic and upper tract oncology, there is continuous evolution and increasing use of these in the field of benign conditions and paediatric urology. As lasers have changed endourology, new minimally invasive surgical techniques (MISTs) have given a new meaning to benign prostate hyperplasia (BPH) surgery. Oncological developments for prostate cancer now include treatments such as robotic prostatectomy, brachytherapy, radiotherapy, cryotherapy and HIFU. Robotic partial nephrectomy and cryotherapy have changed the face of renal cancer. While robotic cystectomy is also gaining popularity for muscle-invasive bladder cancer, new concepts of En-bloc resection of bladder cancer are emerging and being increasingly adopted. MISTs for BPH include laser (Holmium, thulium and green light), water-based treatments (Rezum, Aquablation) and other minimally invasive procedures such as prostate artery embolisation (PAE), TIND and Urolift. There is increasing emphasis on the role of suction in endourological procedures, while the quest for better intrarenal pressure and temperature monitoring continues. The use of Thulium fibre laser (TFL), Moses technology and small disposable ureteroscopes all help in pushing the boundaries of ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL) procedures. These new technological developments have led to improvements in patients’ quality of life (QoL), shorter hospital stays and reductions in complication rates
    Note: English
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  • 7
    Online Resource
    Online Resource
    The Role of Toll-Like Receptors (TLR) in Infection and Inflammation (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576152 , 9783036576145
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: Toll-like receptors (TLRs) represent a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for the induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental, leading to hyper-inflammation, sepsis, and loss of tissue integrity. The involvement of TLRs in inflammation and bacterial infection has been recognized for a long time. There is an increasing number of reports demonstrating the involvement of TLR activation in a variety of viral infections, associated with protective immunity, but also immune hyper activation and even viral replication. Recent data show the involvement of TLR activation in various acute respiratory viral infections, including SARS-CoV-2 and indicate an essential role in COVID-19 pathology. It aimed to gather newest data and hypotheses regarding molecular and cellular mechanisms of TLR triggering and activation and their downstream signaling pathways by viral infections, and their correlation to immunology and pathophysiology of the associated diseases, to facilitate translational research resulting in new targets for the treatment of viral infectious diseases including COVID-19
    Note: English
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  • 8
    Online Resource
    Online Resource
    Biomarkers in Neurodegenerative Diseases 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036557311 , 9783036557328
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine
    Abstract: This book follows up on the previous volume focusing on the different biomarkers for neurodegenerative diseases. It includes original research works and review articles focusing on an improved understanding of disease mechanisms. It also aims to identify aspects of early therapeutic intervention for enhanced disease management. Some critical approaches include studies involving human tissue samples, mouse disease models, and different imaging techniques. These studies present the essential information necessary to address such pathological conditions in the future
    Note: English
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  • 9
    Online Resource
    Online Resource
    The Digital Health in the Pandemic Era (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577333 , 9783036577326
    Language: Undetermined
    Pages: 1 Online-Ressource (298 p.)
    Keywords: Medicine ; Mental health services
    Abstract: Digital health, virtual assistance, and telemedicine are terms often used interchangeably to refer to remote medical assistance, monitoring and care. Several studies and insights have developed these issues, analyzing the advantages and disadvantages and successes and failures and offering reflections on the implications and issues of these technologies in the health domain. The results of these investigations are affecting the redesign of hospital and outpatient management based on digital innovation using eHealth and mHealth. During the COVID-19 pandemic, this approach made it possible to offer assistance and continue care at home, protecting patients, preserving health workers, limiting the spread of the virus, and reducing the need for hospitalization. This reprint contains contributions dealing with the development of DH during the COVID-19 pandemic. The contributions are from various experts in different fields regarding the application of digital health, which, in some cases is also integrated with artificial intelligence, including digital contact tracing, mHealth, virtual reality, mental health, physiology, and rehabilitation
    Note: English
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  • 10
    Online Resource
    Online Resource
    Optic Neuropathies : Current and Future Strategies for Optic Nerve Protection and Repair (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575056 , 9783036575049
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine
    Abstract: Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma
    Note: English
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  • 11
    Online Resource
    Online Resource
    Update on Robotic Gastrointestinal Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576794 , 9783036576787
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Since the introduction of robotic surgery in the early 2000s, several studies have demonstrated its safety and feasibility in various complicated procedures, including esophageal, gastric, and colorectal surgery (for both benign and malignant pathologies), hepatobiliopancreatic surgery, and gynecological and urological procedures.Robot-assisted surgery provides the advantages of a magnified tridimensional view and movement stability without a tremor, which facilitate a precise dissection. The EndoWrist instrument also facilitates dissection at difficult angles, thus enabling surgery in complex conditions.Even if some of the advantages of robotic surgery have been defined, we are still far from clearly recognizing precise indications for a robotic approach in gastrointestinal surgery.With this Special Issue, we aim to investigate the conditions that support the robotic approach in gastrointestinal surgery toward the definition of gold-standard robotic procedures, as established in urological surgery for prostatectomy
    Note: English
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  • 12
    Online Resource
    Online Resource
    Personalized Nursing and Health Care (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574592 , 9783036574585
    Language: Undetermined
    Pages: 1 Online-Ressource (266 p.)
    Keywords: Medicine
    Abstract: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond
    Note: English
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  • 13
    Online Resource
    Online Resource
    Carbazole Derivatives: Latest Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572888 , 9783036572895
    Language: Undetermined
    Pages: 1 Online-Ressource (98 p.)
    Keywords: Medicine
    Abstract: Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, “Carbazole derivatives: latest progress and prospects”, recent studies on carbazole derivatives that are utilized, such as β1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported
    Note: English
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  • 14
    Online Resource
    Online Resource
    Genetic and Epigenetic Regulations of Tumor Progression and Metastasis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571850 , 9783036571843
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine ; Oncology
    Abstract: Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease
    Note: English
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  • 15
    Online Resource
    Online Resource
    New Insights into Contraception (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572765 , 9783036572772
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine
    Abstract: Today, a great variety of contraceptive techniques are available to women; this, coupled with improving the educational levels of female children and adults, is hastening a decline in fertility and consequently, population growth. With the advent of sustained fertility rates lower than replacement levels in many countries, including China and India, we are already witnessing major economic, social, environmental, and geopolitical consequences. Given this situation, today, the promotion of the use of contraception means improving health, not demography, placing emphasis on individuals and not just on methods alone; on the quality of services, and not simply on availability. Indeed, there is an increasing awareness that contraception can help women reduce health risks that are associated with reproductive events and specifically, with unwanted pregnancies. This means that, no matter how ideal a method may be from a purely scientific viewpoint, it must be submitted to the free, decision-making of well-informed women. To contribute to this new user-centric perspective, this reprint presents a series of articles in which technology is considered withing the broader concept of women’s health. Five articles deal with issues related to the users’ and providers’ perspectives; three discuss a modality that is receiving increasing attention, the so-called Long-Acting Reversible Contraception (LARC); and the last three contributions highlight the new advances in oral hormonal contraception
    Note: English
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  • 16
    Online Resource
    Online Resource
    Environmental Exposure to Toxic Chemicals and Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572697 , 9783036572680
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors
    Note: English
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  • 17
    Online Resource
    Online Resource
    Functional Foods as a New Therapeutic Strategy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577081 , 9783036577098
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases
    Note: English
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  • 18
    Online Resource
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    Novel Approaches for Overcoming Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576992 , 9783036576985
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery
    Note: English
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  • 19
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    Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575926 , 9783036575933
    Language: Undetermined
    Pages: 1 Online-Ressource (508 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Arthritis has a high prevalence globally and includes over 100 types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features of the disease, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used in the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of heart attack and other cardiovascular problems. It is therefore crucial that we continue to research the pathogenesis of arthritis and seek to discover novel modes of therapy. This reprint summarizes the themes of the 29 articles published in our Special Issue “Research of Pathogenesis and Novel Therapeutics in Arthritis 2.0”. This reprint details important novel research discoveries that contribute to our current understanding of arthritis
    Note: English
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  • 20
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    Food Addiction, Eating Addiction and Other Forms of Addictive-Like Eating Behavior (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574660 , 9783036574677
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine
    Abstract: There is growing evidence that among persons with disordered eating behavior, the identification of an “addictive-like eating” phenotype for some persons could be relevant and improve our ability to design better tailored interventions. This “addictive-like eating behavior” phenotype encompasses different terms or concepts, including “food addiction”, “eating addiction”, “compulsive eating behavior”, and “food craving”, but also applies to some persons with binge eating disorder, bulimia nervosa, anorexia nervosa, or binge eating symptoms. Although these terms may theoretically refer to different underlying causes or conceptualizations of addictive-like eating, all agree on the complex and multifaceted public health problem it represents and on the similarities it shares with other addictive disorders in terms of etiology, epidemiology, and treatment. Addictive-like eating behavior can deleteriously impact the patient’s outcome and may lead to poorer weight loss evolution, increased prevalence of co-occurring medical and/or psychiatric disorders, and/or lower quality of life. One of the key challenges for the present and future research is to better identify this subpopulation of patients exhibiting this addictive-like eating phenotype, and to identify the psychological/psychiatric factors and biological mechanisms underlying this increased vulnerability to addictive-like eating. Such preliminary knowledge is crucial for enabling the development of interventions targeting these vulnerability risk factors and, ultimately, improving patient outcomes
    Note: English
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  • 21
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    Insect Microbiome and Immunity (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568683 , 9783036568690
    Language: Undetermined
    Pages: 1 Online-Ressource (200 p.)
    Keywords: Medicine
    Abstract: Insects are the most diverse group of organisms, representing approximately 80 percent of the world's species. It is estimated that there are some ten quintillion individual insects alive. During millions of years of evolution, insects developed extraordinary adaptations that allowed them to reside in different habitats. As with all other organisms, insects encounter a wide range of microbes. Although lacking adaptive immunity, they rely on robust innate immune systems to combat these microbes to maintain organismal homeostasis. Conversely, some microbial communities can benefit the host and profoundly affect the host's physiology and overall fitness. Microbiotas have been proven to provide nutrients, promote host defense, and mediate host reproductive behavior. In recent decades, the emergence of high-throughput sequencing has enabled researchers to study host–microbe interactions from the whole microbiome level rather than single microbial species, greatly expanding our knowledge of insect biology
    Note: English
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  • 22
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    Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574615 , 9783036574608
    Language: Undetermined
    Pages: 1 Online-Ressource (250 p.)
    Keywords: Medicine
    Abstract: The reprint, “Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies”, provides a collection of original research articles and systematic reviews focused on diverse conditions stemming from a pathogenic single gene mutation. The articles are focused on the molecular mechanisms that are affected within a rare monogenic disorder, such as those involving gene expression, molecular pathways and cell death. Moreover, specific experimental therapies including drug discovery, drug repositioning, gene therapy and protein-based therapeutics are discussed
    Note: English
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  • 23
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    Advances in Animal Anatomy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573281 , 9783036573298
    Language: Undetermined
    Pages: 1 Online-Ressource (290 p.)
    Keywords: Medicine
    Abstract: This Special Issue covers current and relevant information about the applied anatomy of domestic animals, new companion animals and wild animals. It includes recent research and review articles on diverse topics based on the use of different diagnostic imaging techniques and more classic anatomical methods, providing a deeper insight into the healthy anatomy of diverse structures, which is crucial in high-quality medicine
    Note: English
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    Recent Advances in Psychopathology in Neurodevelopmental Disorders: From Bench to Bedside (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574141 , 9783036574158
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Psychopathology, including functional psychiatric disorders, such as schizophrenia, bipolar disorder, major depressive disorder and anxiety disorders, and also dementia and challenging behaviour, is common in people with neurodevelopmental disorders (NDDs), such as intellectual and developmental disabilities (IDD), autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and is the cause for a major public health concern. Much research has been conducted in the last three decades to understand this issue and develop effective interventions. Still, a lot remains unknown, for which high-quality translational research is urgently needed. In this Special Issue, we drew together research on recent advances addressing these issues. The areas covered included life expectancy among people with and without intellectual disabilities, the social and emotional development of people with intellectual disabilities and ASD, the influence of external environmental factors in determining aggressive behaviour in people with intellectual disabilities, parent and child training for children with autism and intellectual disabilities, how the presence of deafness influences quality of life, the views of prescribers on the deprescribing of antipsychotics among adults with intellectual disabilities, the views of people with intellectual disabilities who took part in the deprescribing, the views of direct-care workers on the causes of challenging behaviours in people with intellectual disabilities, and the validation of tools to detect cognitive decline in adults with intellectual disabilities
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    Antimicrobial Prescribing and Stewardship, 1st Volume (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572550 , 9783036572543
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medicine
    Abstract: This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship;Diagnostic stewardship;Influence of antimicrobial utilisation changes in antimicrobial resistance;Impact of antimicrobial stewardship on quality performance measures and patient outcomes;Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers;Behavioural change approaches to antimicrobial stewardship;Collaborative practice agreements in antimicrobial stewardship;Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology);Tackling AMR through antimicrobial stewardship in low- and middle-income countries;Antimicrobial stewardship for animal health;Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals);Antimicrobial use and stewardship in the context of the COVID-19 pandemic;Global collaborations to tackle AMR through antimicrobial stewardship
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    Immunotherapy in Hepatocellular Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566917 , 9783036566900
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Oncology
    Abstract: Based on this evidence, a deep understanding of the immunological status and biological targets modulating immunological microenvironments should be quite informative for the development of future immunotherapy in HCC. From this point of view, this Special Issue will highlight the current state of the art in the immunotherapy of HCC from both the basic and clinical perspectives, and outline future perspectives for improving therapies
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    Personalized Medicine for Parkinson's Disease : New Concepts and Future of Individualized Management (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562124 , 9783036562117
    Language: Undetermined
    Pages: 1 Online-Ressource (214 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD
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    Pediatric Fractures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561424 , 9783036561417
    Language: Undetermined
    Pages: 1 Online-Ressource (244 p.)
    Keywords: Medicine
    Abstract: This reprint contains original research and review chapters concerning the latest advancements in various topics related to pediatric fractures. Topics include fractures of the face, clavicle, shoulder, elbow, forearm, wrist, pelvis, femur, and tibia; special considerations focus on osteogenesis imperfecta patients; and consideration is also given to general pediatric fracture topics, such as the influence of the COVID-19 pandemic, mortality after pediatric trauma, the effects of NSAID and electronic cigarette use, and chapters on epidemiology and physical activity
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    Biomaterials for Tissue Engineering and Regeneration (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563619 , 9783036563602
    Language: Undetermined
    Pages: 1 Online-Ressource (366 p.)
    Keywords: Medicine
    Abstract: Biomaterials are an integral component of tissue engineering, and their development is crucial to the progress of new and efficient approaches in the regenerative medicine of bone, cartilage, tendons and ligaments, skin, soft-tissue wounds, cardiac muscle, vascular tissues, and neural tissues.Polymer-based biomaterials are extensively studied in the field of tissue engineering due to their biocompatible and biodegradable properties. This Special Issue is devoted to recent developments of synthetic and/or natural biomaterial scaffolds, hydrogels, polypeptides, polymer-based composites, and composites based on polymers and inorganic materials, such as bioactive ceramics and glasses. New technologies (e.g., bioprinting, additive manufacturing, etc.) used to form biomaterials for tissue engineering of three-dimensional (3D) constructs are of particular interest
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    Spectroscopic, Thermodynamic and Molecular Docking Studies on Molecular Mechanisms of Drug Binding to Proteins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562261 , 9783036562254
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated
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    Biomaterials for Bone Tissue Engineering 2020 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561042 , 9783036561035
    Language: Undetermined
    Pages: 1 Online-Ressource (242 p.)
    Keywords: Medicine
    Abstract: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration
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    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis : Diagnosis and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559698 , 9783036559704
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches
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    State of the Art in Idiopathic Pulmonary Fibrosis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563855 , 9783036563848
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: This reprint is a compilation of ten publications, including original-research and review articles, and the accompanying editorial within the scope of a Special Issue entitled: "State of the Art in Idiopathic Pulmonary Fibrosis" published in Cells
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570419 , 9783036570402
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy
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    Molecular Mechanisms of Steroid Hormone Biosynthesis and Action (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570037 , 9783036570020
    Language: Undetermined
    Pages: 1 Online-Ressource (360 p.)
    Keywords: Medicine
    Abstract: Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones
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    Angiogenesis in Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569161 , 9783036569178
    Language: Undetermined
    Pages: 1 Online-Ressource (274 p.)
    Keywords: Medicine ; Oncology
    Abstract: Tumor progression is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors. Inflammatory infiltration contributes to tumor progression and metastatic process, and there are many reports of associations between tumor inflammatory infiltration, progression and prognosis. New therapeutic approaches have been developed with the aim to control tumor progression through the targeting of different components of the tumor microenvironment. This reprint will be useful for anyone who wants to learn about cancer: professors and students at universities, scientists at research institutes, biotechnology, and pharmaceutical labs, and lawyers trying to understand the patent literature
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    Advances in Neuroimaging Data Processing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569987 , 9783036569994
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications
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    Focus on Antibiotics – New Challenges and Steps Forward in Discovery and Development (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572017 , 9783036572000
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The Special Issue "Focus on Antibiotics - New Challenges and Steps Forward in Discovery and Development" addresses the latest efforts towards discovering new antibiotics. The articles in this Special Issue cover various topics concerning antibacterial drugs. They provide valuable insights into the challenges and opportunities facing the field of antibiotic research and offer innovative solutions to tackle the growing problem of antibiotic resistance. The content of this Special Issue addresses antibacterial quinolones of the latest generation, new tetracyclines (such as glycylcyclines, aminomethylcyclines, and fluorocyclines), metal complexes (Ru (II/III) frameworks and Co(III) complexes with diamine chelate ligands), various nanoparticles (gold, silver and titanium dioxide nanoparticles), bioactive compounds produced by Mixobacterials species, anti-mycobacterial compounds acting as phosphopantetheinyl transferase inhibitors. The research in this Special Issue will contribute to pharmaceutics and ultimately contribute to developing new and effective antibiotics. We are grateful to the authors for their contributions and hope this Special Issue will stimulate further research and discussion on antibiotics. We also thank the reviewers for their time and expertise, and the editorial team for supporting this Special Issue. Finally, we hope this Special Issue will serve as a valuable resource for researchers, clinicians, and policymakers working towards a future where antibiotics remain vital in our fight against infectious diseases
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    Nutritional Support for Chronic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570624 , 9783036570631
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Medicine
    Abstract: Diet contributes to the development of many chronic conditions including obesity, cardiovascular disease, hypertension, stroke, type 2 diabetes, metabolic syndrome, some cancers, non-alcoholic fatty liver disease, and potentially some neurological diseases. This reprint addresses associations between diet (and specific nutrients including vitamin D) and various chronic diseases including obesity, cardiovascular disease, hypertension, stroke, diabetes, metabolic syndrome, non-alcoholic fatty liver disease, neurological conditions, and age-related macular degeneration. More specifically, the impacts of plant-based diets, dairy products, and ketogenic diets are explored in relation to chronic disease risk as well as some benefits of the consumption of oral nutritional supplements in the prevention of malnutrition and sarcopenia and in the treatment of wounds in individuals with diabetes. Additional topics that are covered include some roles of the fatty acid arachidonic acid in the body and the impact of cellular mitochondrial dysfunction on the progression of age-related macular degeneration. The effectiveness of a variety of nutraceuticals is covered as a means for the prevention or treatment of age-related macular degeneration. Lastly, the use of olive oil in reducing gut permeability in those with pre-diabetes is addressed, as well as the complex relationships of diet/food and of disease (metabolic syndrome) with the gut microbiota
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    Novel Anticancer Strategies (Volume II) (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570334 , 9783036570327
    Language: Undetermined
    Pages: 1 Online-Ressource (700 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells
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    Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570150 , 9783036570143
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medicine ; Oncology
    Abstract: Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the “one-size-fits-all” approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients
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    Tryptophan in Nutrition and Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570778 , 9783036570761
    Language: Undetermined
    Pages: 1 Online-Ressource (324 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society
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    A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569185 , 9783036569192
    Language: Undetermined
    Pages: 1 Online-Ressource (414 p.)
    Keywords: Medicine ; Physiology
    Abstract: This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology
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    Sensor Technology for Sports Monitoring (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570884 , 9783036570891
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine
    Abstract: In order to be able to analyze and give proper advice on sport techniques, it is important to understand the biomechanical and physiological demands of different sports. In a coaching situation, feedback to the athlete should be given without too much delay. Over the past decades, sensor technology-related to sports monitoring has developed with huge steps. Senors are lighter, data transmission is mostly wireless, and software applications are more user-friendly. This reprint is addressed to all kinds of sensors that are currently being used for monitoring different sports
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    Biomarkers of Stress in Companion Animals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571249 , 9783036571256
    Language: Undetermined
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Medicine
    Abstract: The welfare of an individual could be severely affected by stressful events. Mainly for this reason, the scientific community is interested in finding specific and quantifiable characteristics which could indicate or predict specific signs of acute or chronic stress exposure. The aim of this reprint is to reflect this interest in the field of companion animal physiology. The authors engaged in publishing this reprint are experts in the multiple mechanisms involved in stress response, including the detection of behavioral and physical signs which can be measured through biological indicators of homeostasis displacement. The editors strongly believe this topic will be of interest not only to researchers in this field, but also to dog trainers, dog shelter workers and veterinary behaviorists
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    Nutrition at the Interface of Sleep and Circadian Rhythms: Implications for Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567082 , 9783036567099
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: An integral part of homeostasis includes daily rhythms in physiology, behavior, and metabolism. The circadian timing system enables organisms to adapt their biological functions to the cyclic nature of the Earth. Sleep is a fundamental physiological function, playing a crucial role in physical, mental and emotional health. Alterations of sleep quality and quantity caused by modern lifestyle and behavior as well sleep disorders are associated with an increased risk for chronic diseases. Chronic misalignment of endogenous rhythms can also lead to metabolic dysfunction. Research is starting to demonstrate the complex interrelationship between nutrition, sleep and the circadian system. For example, some foods and nutrients may impact the availability of substances that influence sleep. On the other hand, inadequate sleep is associated with an unhealthy nutrient intake and altered metabolism. Nutrients can act as drivers of circadian rhythms; they have the ability to influence circadian regulation and alter biological functions in specific tissues. A lacuna still exists in the knowledge surrounding the interplay of nutrition with sleep and the circadian system. In light of this, novel opportunities are disclosed for developing tailored nutritional recommendations with beneficial effects on sleep and circadian rhythmicity so as to improve life quality and prevent disease. The purpose of this Special Issue is therefore to collect contributions regarding this interplay and the related clinical implications
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    The Pathophysiology of Preeclampsia and Eclampsia (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564111 , 9783036564104
    Language: Undetermined
    Pages: 1 Online-Ressource (334 p.)
    Keywords: Medicine
    Abstract: Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells
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    Dietary Curcumin and Health Effects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036560878 , 9783036560885
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The Special Issue provides twelve contributions, of which three original articles, seven narrative reviews, one systematic review, and one meta-analysis that, altogether, offer a multifaceted and multidisciplinary overview that allows to draw a picture as intriguing and fascinating as possible on the benefits of curcumin and also to suggest potential fields of activities still to be explored. Among the biological activities exerted by curcumin, the anti-oxidative and anti-inflammatory properties reported in many studies make it a potential effective tool in preventing and counteracting chronic-degenerative diseases, very often associated with obesity and aging, such as cardiovascular diseases, T2D, metabolic dysfunctions, neurodegenerative diseases, and cancer, all of them characterized by the presence of oxidative and inflammatory processes. The main concerns that arise from the evaluation of the preventive/therapeutic effects of curcumin are, first of all, the still small number of randomized placebo-control studies available; in addition, small sample sizes have generally been considered, and different protocols and different formulations as well as different routes of administration of curcumin have been used. Thus, it is quite difficult to compare the results and to provide a standard protocol for the use of this promising natural compound. For these reasons, and taking in account the growing use of curcumin by the general population, further investigations to confirm and expand current findings are mandatory and research on curcumin and its effects on human health have to be fostered and promoted
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    Ciguatoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564289 , 9783036564296
    Language: Undetermined
    Pages: 1 Online-Ressource (358 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
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    Assessing Atmospheric Pollution and Its Impacts on the Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563213 , 9783036563206
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases
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    Marine Toxins from Harmful Algae and Seafood Safety (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561943 , 9783036561936
    Language: Undetermined
    Pages: 1 Online-Ressource (264 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The rapid expansion of aquaculture around the world is increasingly being impacted by toxins produced by harmful marine microalgae, which threaten the safety of seafood. In addition, ocean climate change is leading to changing patterns in the distribution of toxic dinoflagellates and diatoms which produce these toxins. New approaches are being developed to monitor for harmful species and the toxins they produce. This Special Issue covers pioneering research on harmful marine microalgae and their toxins, including the identification of species and toxins; the development of new chemical and biological techniques to identify and monitor species and toxins; the uptake of marine biotoxins in seafood and marine ecosystems; and the distribution and abundance of toxins, particularly in relation to climate change
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    Clinical Features and Long-Term Outcomes of Systemic Lupus Erythematosus (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561103 , 9783036561097
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The clinical spectrum of systemic lupus erythematosus (SLE) is highly heterogeneous, ranging from mild disease, which can be limited to skin and joint involvement, to life-threatening conditions with renal impairment, severe cytopenias, central nervous system disease, and thromboembolic events. Apart from the host genetics, several environmental factors, such as sunlight, infections, drugs, and probably hormonal factors, can trigger the onset of symptoms related to SLE. Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE still have significant rates of premature mortality and many patients experience severe disease with increased risk of sustaining organ damage and having a reduced health-related quality of life. The development of effective drugs that can induce remission or low disease activity, the unanimous use of definitions of remission and low or high disease activity, flare, and response to therapy, the identification of non-invasive biomarkers of disease activity and long-term outcomes, and the implementation of SLE patients’ perspectives as an integral part of the clinical assessment constitute only a few of the many unmet needs in the field of SLE
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    Advanced Blood-Brain Barrier Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564173 , 9783036564166
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB)
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    In Silico Strategies for Prospective Drug Repositionings (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561349 , 9783036561332
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions
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    3D Printed Materials Dentistry (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568881 , 9783036568898
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine ; Pharmacology ; Research & information: general ; Chemistry
    Abstract: The Special Issue reprint covers a wide range of applications of 3D-printing in dentistry. Five out of eleven research papers deal with applications of 3D printing in orthodontics, one study presents a 3D-printed fitting system for the FFP2 that were applied during the COVID-19 pandemic, and the others address applications in prosthodontics and restorative dentistry
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    Artificial Intelligence in Cancer Diagnosis and Therapy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036566726 , 9783036566733
    Language: Undetermined
    Pages: 1 Online-Ressource (672 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint covers some significant impacts in the recent research in both the private and public sectors of cancer diagnosis and therapy, in which Artificial Intelligence (AI) and Machine Learning are significant. This reprint is also a collection of forty different complex and challenging problems arranged in five groups: AI in prognosis, grading, and prediction, AI in clinical image analysis, AI models for pathological diagnosis, ML and statistical models for molecular cancer diagnostics and genetics, and AI in triage, risk stratification, and screening cancer, which are all focused on using AI in cancer diagnosis and therapy. All the necessary concepts, solutions, methodologies, and references are supplied except for some fundamental knowledge that is well-known in the general fields of AI and cancer diagnosis and therapy. The readers may, therefore, gain the main concepts of each chapter, with as little of a need as possible to refer to the concepts of the other chapters and references. The readers may hence start to read one or more chapters of the book for their own interests
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    Personalized and Precision Medicine 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570457 , 9783036570440
    Language: Undetermined
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Medicine
    Abstract: This reprint, guest edited by Anne-Marie Caminade, gives an impressionist overview of the current state of the art about “Personalized and Precision Medicine”. Twenty contributions illustrate the diversity of the topic, including new approaches about cancers, neurodegenerative diseases, infectious diseases, lungs obstruction, skeletal diseases, intestinal microbiomes, new tools such as ultra-high-frequency ultrasound or non-oncological radiotherapy, and a new class of drugs (dendrimers). This reprint is an illustration of the present and future impact of Personalized and Precision Medicine on all the therapeutic domains
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    Antimicrobial Therapy in Intensive Care Unit (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036567693 , 9783036567686
    Language: Undetermined
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Medicine
    Abstract: This reprint is an excellent collection of articles that deal with difficult-to-treat infections in the ICU environment. Multiresistant bacteria and fungi create severe treatment problems to the physician charged with their care. We hope that this book will help everyday dilemmas and add useful information on difficult topics
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    Urological Cancer 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036569680 , 9783036569697
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine ; Oncology
    Abstract: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit
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    Marine Anti-inflammatory and Antioxidant Agents 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036567846 , 9783036567853
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medicine
    Abstract: The Special Issue “Marine Anti-Inflammatory and Antioxidants Agents 2.0” collects in vitro and/or in vivo experimental investigations highlighting the role of marine-derived bioactive compounds as modulators of inflammation and/or oxidative stress, papers describing the mechanisms of action and molecular interactions of compounds isolated from marine organisms, and comprehensive review articles summarizing knowledge on marine anti-inflammatory and/or antioxidant agents in support of human health
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    Current Challenges and Advances in Cataract Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036562773 , 9783036562780
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed
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    Biosimilars in Europe (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036565750 , 9783036565743
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries
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    Stabilization and Resuscitation of Newborns (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036564470 , 9783036564463
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine
    Abstract: The majority of newborns do not need medical interventions to manage the neonatal transition after birth. However, every year millions of newborns worldwide require respiratory support immediately after birth, and another considerable number of newborns additionally require extensive resuscitation including chest compressions and drug administration. Despite a significant increase in knowledge and development of enhanced therapy strategies over the past few years, morbidity and mortality caused by failures in neonatal transition remain an important health issue. The purpose of this reprint is to support or introduce novel concepts and add information in the area of the “Stabilization and Resuscitation of Newborns”, aiming to improve neonatal care and, as the major objective, to enhance neuro-developmental outcomes
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    Molecular Mechanisms and Therapies of Colorectal Cancer (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565477 , 9783036565460
    Language: Undetermined
    Pages: 1 Online-Ressource (294 p.)
    Keywords: Medicine ; Oncology
    Abstract: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human development.In clinics, despite advances of diagnosis and surgical procedures, 20% of the patients with CRC present with metastasis at the time of diagnosis, caused by residual tumor cells that have spread to distant organs prior to surgery, affecting the patient survival rate. Standard systemic chemotherapy, alternative therapies that target mechanisms involved in cancer progression and metastasis, immunotherapy, and combination therapies are the major CRC-treatment strategies. In the advanced stage of CRC the transforming growth factor-beta (TGF-β) plays an oncogenic role by promoting cancer cell proliferation, cancer cell self-renewal, epithelial-to-mesenchymal transition, invasion, tumor progression, metastatic spread, and immune escape. Furthermore, high levels of TGF-β1 confers poor prognosis and is associated with early recurrence after surgery, resistance to chemo- or immunotherapy, and shorter survival. Based on the body of experimental evidence indicating that TGF-β signaling has the potential to be a good therapeutic target in CRC, several anti-TGF-β drugs have been investigated in cancer clinical trials. Here, we presented a comprehensive collection of manuscripts regarding studies on targeting the TGF-β signaling in CRC to improve patient’s prognosis and personalized treatments
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    Research on Pathogenic Fungi and Mycotoxins in China (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036562698 , 9783036562704
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins
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    Endocrine and Neuroendocrine Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036557632 , 9783036557649
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Oncology
    Abstract: Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available. This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives
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    Capitalizing a Cure : How Finance Controls the Price and Value of Medicines (2023)
    [Erscheinungsort nicht ermittelbar] : University of California Press
    Details
    ISBN: 9780520388710
    Language: Undetermined
    Pages: 1 Online-Ressource (217 p.)
    Keywords: Political economy ; Medicine
    Abstract: Capitalizing a Cure takes readers into the struggle over a medical breakthrough to investigate the power of finance over business, biomedicine, and public health. When curative treatments for hepatitis C launched in 2013, sticker shock over their prices intensified the global debate over access to new medicines. Weaving historical research with insights from political economy and science and technology studies, Victor Roy demystifies an oft-missed dynamic in this debate: the reach of financialized capitalism into how medicines are made, priced, and valued. Roy’s account moves between public and private labs, Wall Street and corporate board rooms, and public health meetings and health centers to trace the ways in which curative medicines became financial assets dominated by strategies of speculation and extraction at the expense of access and care. Provocative and sobering, this book illuminates the harmful impact of allowing financial markets to determine who heals and who suffers and points to the necessary work of building more equitable futures. “An important voice on the links between finance and health ecosystems, Victor Roy makes a valuable contribution to building an economy that is based on providing health for all.” — Mariana Mazzucato, author of The Value of Everything: Making and Taking in the Global Economy and Chair of the WHO Council on the Economics of Health for All “This book is a riveting read that will strike fear in the heart of anybody who cares about the right to health or thinks that the drive for profits should not supersede democracy or human need.” — Salmaan Keshavjee, author of Blind Spot: How Neoliberalism Infiltrated Global Health “The best piece of nonfiction I have read in a long time. This book offers a fantastic, relevant, and necessary case study to understand how the financialization of the economy has affected the organization of industrial sectors.” — Marc-André Gagnon, Professor of Public Policy and Political Economy, Carleton University
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    Challenges and Opportunities for Effective Cancer Immunotherapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569604 , 9783036569611
    Language: Undetermined
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Medicine
    Abstract: Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments
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    Model-Informed Precision Dosing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568966 , 9783036568973
    Language: Undetermined
    Pages: 1 Online-Ressource (320 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs
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    Multi-Functional Collagen-Based Biomaterials for Biomedical Applications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570730 , 9783036570723
    Language: Undetermined
    Pages: 1 Online-Ressource (234 p.)
    Keywords: Medicine
    Abstract: Polymeric biomaterials represent an essential tool in the biomedical field. Their high biocompatibility and ability to provide adequate regenerative support are fundamental for the development of new therapeutic devices. In particular, biomaterials derived from living organisms can exhibit not only structural roles but also several non-structural functions implicated in cellular growth, migration, and differentiation. Among them, type I collagen, a ubiquitous structural protein present in the mammalian body, plays a dominant role in maintaining the biological and structural integrity of various tissues. In recent years, with the goal of developing multi-functional collagen-based devices able to better promote the functional recovery of damaged tissues, numerous studies have focused on novel techniques and methods for the development and characterization of innovative and advanced high-performance formulations. The ability to control, modify, and tune collagen-based biomaterials performance by optimizing their architecture, besides modifying their chemistry, blending with other materials/therapeutics, or developing stimuli-responsive formulations, is an extremely important knowledge to acquire when specific multi-functionalities are sought.The present Special Issue collected 12 peer-reviewed interdisciplinary contributions on the broad topic of multi-functional collagen-based biomaterials
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    COVID-19: Current Status and Future Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567402 , 9783036567419
    Language: Undetermined
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic
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    State-of-the-Art in Orthodontics and Gnathology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569369 , 9783036569376
    Language: Undetermined
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medicine
    Abstract: The objective of this reprint is to present the main evidence-based data on new developments and knowledge in diagnostic and treatment technologies in the orofacial field used in both children and adults. The published content has been met with great success in interdisciplinary fields, stimulating international authors to submit their original articles, reviews, or case reports based on various aspects of orthodontics as well as on the diagnosis and management of temporomandibular disorders and orofacial pain. Among the current highly debated topics, this reprint focuses on multiple disciplines as follows: gingival recessions and periodontal status after orthodontic treatment; a rare case of impacted central incisors; predictors of analgesic consumption in orthodontic patients; a systematic review about different dentoskeletal class III treatment approaches; evaluation of upper airway volumes; and cephalometric values in JIA patients
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    Immunohistochemical and Physiological Research on Farm Animals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568829 , 9783036568836
    Language: Undetermined
    Pages: 1 Online-Ressource (318 p.)
    Keywords: Medicine
    Abstract: This reprint represents a collection of papers that aimed to highlight the importance of immunohistochemical findings and their role in improving the understanding of organ tissue functions. We focused our attention on farm animals because they represent not only a source of food in the supply chain, but also a source of income for breeders, a source of employment, and a primary tool in the quest for sustainable food production. To achieve this last aim, we asked authors for research that could potentially be applied to the purpose of this study, and whose results could be useful in improving farm management practices and the responsible use of natural resources. A total of 20 papers were contributed to this issue, written by 118 authors from 4 countries, and comprising 18 research articles and 2 communications articles
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    Honorary Doctorate Dr. Souha Kanj (2023)
    Nijmegen : Radboud University Press
    Details
    Language: Undetermined
    Pages: 1 Online-Ressource (38 p.)
    Keywords: History ; Medicine
    Abstract: On 15 October 2020, in the middle of the COVID-19 pandemic, Dr. Souha Kanj received a Radboud honorary doctorate in recognition of her achievements in the field of infection control and prevention, efforts in antimicrobial stewardship, and research on various infectious diseases, particularly antimicrobial resistant (AMR) bacteria. This edition includes the laudatio and the speech of our honorary doctor. Kanj published the first overview of antibiotic resistance in Arab countries and discovered differences between neighboring countries in the epidemiology of antimicrobial resistance. She also developed infection prevention monitoring and education programs for healthcare workers, and private organizations in the Arab world. Thanks to her efforts, Lebanon has signed the WHO pledge for hand hygiene. Kanj is not only commended for her expertise, didactic skills, and contribution to medicine, but also for her resilience and strong belief in making a positive impact, despite the difficult journey she has been through, having studied during the Lebanese civil war and being faced with numerous challenges that hit Lebanon and the region after that
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  • 75
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    Outcomes and Therapeutic Management of Thyroid Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562636 , 9783036562643
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Globally, the impact of differentiated thyroid cancers has significantly increased in the last decade, resulting in growth of public health spending. Many international scientific societies are actively involved in the difficult process of building updated guidelines in response to scientific research, especially in the genetic and immunohistochemistry fields. The watch, wait, and see policy has added a new possibility for patients in selected cases. Considering the recognized international interest in this disease, this Special Issue aims to analyze the most recent acquisitions in terms of the diagnosis and therapy of differentiated thyroid cancer. It will offer the reader an updated point of view of the most illustrious endocrinology and endocrine-surgery international schools
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  • 76
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    Potentially Toxic Elements Pollution in Urban and Suburban Environments (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562377 , 9783036562384
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The importance of studying pollution via potentially toxic elements (PTEs) is becoming a key challenge considering the increasing concern about the presence of PTEs in the environment and their potential impacts on ecosystem functioning and public health due to their persistence and biotoxicity. Regional geochemical research, together with geostatistical computations which are used to identify source patterns of different pollutants related to the underlying geological features and/or anthropogenic activities, is the best approach for characterizing this pollution issue. The collection of research in this Special Issue, “Potentially Toxic Element Pollution in Urban and Suburban Environments”, represents the need of the scientific community to characterize the behavior, transport, fate, and ecotoxicological state of PTEs in environmental matrices in both urban and suburban settings. All the case studies collected are of relevant significance due to their quality, both in the methodologies and the achieved results, and interest to different environmental studies, from China to South Africa to Europe. My role as Guest Editor of this Special Issue was exciting and stimulating. I would like to express my appreciation to all the authors for submitting their original contributions and to the reviewers for their essential role in the process. I would like to thank the editors of Toxics and, in particular, Selena Li for her precious and tireless support
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  • 77
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    Hepatic Encephalopathy : Clinical Challenges and Opportunities (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563381 , 9783036563398
    Language: Undetermined
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medicine
    Abstract: Hepatic encephalopathy (HE) is a complex neurological syndrome, characteristic of patients with liver disease, that causes a wide and complex spectrum of nonspecific neurological and psychiatric manifestations, ranging from a subclinical entity such as minimal or covert hepatic encephalopathy to a deep form in which a complete alteration of consciousness can be observed: overt hepatic encephalopathy. Both minimal and overt hepatic encephalopathy have a high impact on patients, caregivers, and national health services, driving substantial consumption of economic resources. In this Special Issue, we discussed the current state-of-the-art research, address ongoing knowledge gaps, and ongoing controversies related to the pathogenesis, diagnosis, and therapeutic management of hepatic encephalopathy
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  • 78
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    Hyperbaric Medicine (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564678 , 9783036564661
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine
    Abstract: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars
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  • 79
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    Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563183 , 9783036563190
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories
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  • 80
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    Induced Impairment of Neurogenesis and Brain Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562148 , 9783036562131
    Language: Undetermined
    Pages: 1 Online-Ressource (282 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders
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  • 81
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    Detection, Control and Contamination of Mycotoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563503 , 9783036563510
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The objective of this collection is to illustrate the most recent research on the development of novel and/or rapid methods for mycotoxin determination, and to propose new strategies for monitoring and/or reducing mycotoxin contamination. Innovative sample preparation techniques or protocols and the possibility of multiclass mycotoxin detection will be very positively considered for possible inclusion in this Special Issue. Both methods based on (bio)sensors and chromatography with various detectors (including mass spectrometry) are welcome. Applications of already published methods on new matrices without any modification will not be accepted. However, extensive studies and monitoring on the spread of contamination through the food production chain could be of interest for this collection
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  • 82
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    Biomedical Imaging Technologies for Cardiovascular Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570068 , 9783036570075
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint aims to provide an update on the biomedical imaging technologies that can be used for cardiovascular diseases, including Doppler echocardiography, magnetic resonance imaging and positron emission tomography. Cardiovascular disease imaging assessment includes anatomy, hemodynamics, and tissue biomarkers, which aid the stratification of patient risk and therapy. In addition, this Special Issue includes articles that discuss the recent integration of artificial intelligence and machine learning, in order to support novel approaches to personalized image-based diagnosis
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  • 83
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    Parasites and Wildlife (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568522 , 9783036568539
    Language: Undetermined
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint focuses on field studies aimed at unraveling the complex networks created by interactions between parasites and hosts in a given ecosystem. Since most transboundary diseases have been propagated from the wilderness to anthropized areas, societies are increasingly concerned about the relevance of wildlife as it pertains to global health. In this respect, research on parasites that may affect the biology and population equilibrium of wildlife is of major interest, especially when a One Health perspective is considered. The studies compiled in the present Special Issue fall within several areas of interest, such as epidemiology, diagnosis, emerging zoonoses, food safety, conservation issues, parasite–host interactions, and the pathology of infections caused by parasites in wild host species
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  • 84
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    Novel Applications and Technologies for the Industrial Exploitation of Algal Derived Marine Bioactives as Nutraceuticals or Pharmaceuticals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570082 , 9783036570099
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The active molecules or bioactives (i.e., polysaccharides, fatty acids, proteins, polyphenols, diterpenes, steroids and alkaloids) from algae (seaweed and microalgae) have been widely studied in recent years for multiple pharmaceutical and nutraceutical applications. Innovative and emerging technologies, including but not limited to ultrasounds, microwaves, electric fields, high-pressure supercritical fluids, ionic fluids and plasma, are currently being explored throughout multiple stages of the pre-treatment, extraction, isolation/purification and preservation of biomolecules from algae. This Special Issue will target research papers, reviews, short communications and perspectives on the use of novel technologies for the pre-treatment, extraction, isolation‒purification, characterization and preservation of marine compounds from algae. It will particularly focus on novel research related to algal bioactives with clear and demonstrated industrial applications and focuses
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  • 85
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    Novel Anticancer Strategies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570310 , 9783036570303
    Language: Undetermined
    Pages: 1 Online-Ressource (396 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies reviews important findings and updates within the cancer therapy field, of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key features: Nanoparticle-based drug delivery in cancer therapy; Extracellular vesicles for anticancer drug delivery; Peptide-based drug conjugates; Cancer stem cells as a valuable target to eradicate tumor relapse; Spheroids in preclinical model for cancer research; and cancer immunotherapy
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  • 86
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    Chemical and Biological Threats, Hazard Potential and Countermeasures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036550374 , 9783036550381
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: In this Special Issue of Toxics entitled, “Chemical and biological threats, hazard potential and countermeasures”. In this special issue we would like to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally or on purpose endanger human health. Besides the characterization of such threats and their biological consequences we will focus on the available and novel experimental countermeasures capable to protect from and/or threat such exposures
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  • 87
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    Feature Papers in 〈em〉 NeuroSci 〈/em〉: From Consciousness to Clinical Neurology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036578460 , 9783036578477
    Language: Undetermined
    Pages: 1 Online-Ressource (256 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: This reprint focuses on relevant findings in the field of neuroscience, ranging from cognitive neuroscience, including studies on human consciousness, to clinical neurology, including studies on autism and epilepsy. Furthermore, the latest methods in the expanding field of neuroscience from cognitive to clinical subdisciplines will also be available to the readers
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  • 88
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    Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036583839 , 9783036583822
    Language: Undetermined
    Pages: 1 Online-Ressource (400 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint contains five original research papers and eight review articles for the Special Issue "Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components" which is guest edited by Prof. Dr. Anupam Bishayee. There is one item that indicated the correction of one review
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  • 89
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    Biomechanics-Based Motion Analysis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036580272 , 9783036580265
    Language: Undetermined
    Pages: 1 Online-Ressource (386 p.)
    Keywords: Medicine
    Abstract: Collectively, the studies presented in this reprint have used various validated biomechanical models or proposed novel methods of motion analysis to gain new insights into health-related problems and sports performance
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  • 90
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    Marine Bioactive Peptides—Structure, Function, and Application (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036582603 , 9783036582610
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In recent years, peptides generated from various marine organisms have attracted wide attention due to their diverse chemical structures and bioactivities, including antioxidant, immune-modulating, angiotensin-I-converting enzyme (ACE)-inhibitory, hypotensive, hypolipidemic, antiviral, cytotoxic, neurotoxic, anticoagulant, antifreeze, etc. Moreover, bioactive peptides can serve as additional functional components used in health foods, nutraceuticals, bio-preservatives, cosmetics, and pharmaceuticals. The Special Issue on “Marine Bioactive Peptides—Structure, Function, and Application” aimed to collect papers on up-to-date information regarding the preparation, structural identification, activity and functional evaluation, and application of marine bioactive peptides
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  • 91
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    Recent Advances of Novel Pharmaceutical Designs for Anti-cancer Therapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036583112 , 9783036583105
    Language: Undetermined
    Pages: 1 Online-Ressource (268 p.)
    Keywords: Medicine ; Oncology
    Abstract: This Special Issue covers a well-balanced collection of state-of-the-art topics in the prospering and competitive field of anticancer drug design and development, which can address and inspire oncologists, biologists, and medicinal chemists among the readership of this journal
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  • 92
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    Recent Approaches for Wound Treatment (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036586977 , 9783036586960
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The aim of this Special Issue is to describe the recent approaches for and efficacious treatment of wounds from different aspects. These include the description of new ingredients (e.g. A.P.I., polymers) able to stimulate the wound healing, new delivery systems, new formulations as well as new understanding in the stimulation of physiological biochemical pathways (that change according to many factors such as age, sex, etc.) involved in wound healing
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  • 93
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    Skeletal Radiology (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036584355 , 9783036584348
    Language: Undetermined
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Musculoskeletal (MSK) disorders are among the top five contributors to disability-adjusted life years (DALYs) worldwide. These disorders include a wide range of conditions, spanning from fractures, sports injuries, rheumatoid arthritis, and musculoskeletal pain syndromes to those mostly affecting older age groups like osteoarthritis and osteoporosis. MSK conditions often present diagnostic challenges due to overlapping symptoms, complex anatomical aspects, and the variety of potential causes. Imaging plays a pivotal role in diagnosing and guiding treatment for these disorders. In the past decade, the MSK radiology field has witnessed significant progress driven by breakthroughs in artificial intelligence (AI), the development of high-resolution equipment and novel imaging sequences, and the adoption of innovative multidisciplinary approaches. This Special Issue on skeletal radiology brings together a diverse collection of articles that showcase the latest advancements in this field. From evaluating flatfoot to exploring emerging targets for osteoarthritis treatment, the included studies provide valuable insights into diagnostic accuracy and the expanding applications of skeletal radiology techniques. This editorial aims to highlight the significance of these articles and their contributions to the field of skeletal radiology
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  • 94
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    Updates on Molecular Targeted Therapies for CNS Tumors (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036585284 , 9783036585291
    Language: Undetermined
    Pages: 1 Online-Ressource (368 p.)
    Keywords: Medicine ; Oncology
    Abstract: The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular targets must be key drivers in the growth and progression of CNS tumors. Numerous potentially efficacious therapies have failed in randomized clinical trials due to other factors, including subclonal genetic intratumoral heterogeneity (particularly within malignant gliomas), epigenetic heterogeneity, and failure to target important factors involved in the tumor microenvironment. Developing effective targeted therapies requires a thorough fundamental understanding of the genetic and epigenetic factors driving tumor progression, the interactions between CNS tumor cells and the tumor microenvironment, and the key mechanisms of tumor treatment resistance. In this Special Issue, experts in the field of CNS tumors will highlight the most promising molecular targets in the development of treatments for patients with CNS tumors
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  • 95
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    Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036581880 , 9783036581897
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented
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  • 96
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    Respiratory Disease in the COVID-19 Era (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579160 , 9783036579177
    Language: Undetermined
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Coronavirus disease 2019 (COVID-19) is a new respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused a global pandemic. COVID-19 patients often develop acute respiratory distress syndrome (ARDS), which involves acute and lethal respiratory failure. In a meta-analysis, the median incidence of ARDS in COVID-19 patients was found to be 35 (2-79)%, while the mortality rate in COVID-19-associated ARDS patients was found to be 39 (12.5-73.1)% (Hasan, et al. Expert Rev Repoir Med. 2020; 14: 1149). As of 12 December 2021, 270,373,764 cases had been confirmed as COVID-19 and 5,321,321 cases had resulted in death, according to the World Health Organization webpage. Various symptoms such as persistent fatigue, myalgia, and insomnia can persist after recovery from COVID-19; these symptoms are called “long COVID-19”. Patients with COVID-19 who survive but develop pulmonary fibrosis may experience persistent dyspnea upon exertion, a decrease in pulmonary function, and/or a radiological abnormal shadow. Antifibrotic drugs including nintedanib and pirfenidone are candidate drugs for the treatment of pulmonary fibrosis due to COVID-19; randomized controlled trials are ongoing. However, there are limited studies about respiratory disease caused by COVID-19. Given the clinical significance of this topic and its impact on clinical practice and public health, Medicina have published a Special Issue entitled “Respiratory Disease in the COVID-19 Era” with the aim of gathering accurate and up-to-date scientific information of this topic
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  • 97
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    Coronary Syndrome: Clinical Treatment, Prevention and Management for Better Outcomes (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579122 , 9783036579139
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes
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  • 98
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    Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579375 , 9783036579368
    Language: Undetermined
    Pages: 1 Online-Ressource (184 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint brings together a group of articles that were published as a Special Issue on prosthetic joint infection in the journal Antibiotics. They cover various aspects of risk factors and prevention, medical and surgical treatment, and outcomes of prosthetic joint infections
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  • 99
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    Therapeutic Potential for Cannabis and Cannabinoids (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575827 , 9783036575834
    Language: Undetermined
    Pages: 1 Online-Ressource (424 p.)
    Keywords: Medicine
    Abstract: Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cannabis (as well as synthetic analogs). Currently, nearly 50 countries permit the medical use of cannabis, and over a dozen other countries have legalized cannabis-based products (CBD, Sativex, Dronabinol, etc.) for medical use. While there exists a plethora of anecdotal reports indicating that cannabis can treat a variety of diseases, there is a limited amount of strong, evidence-based scientific data to support these claims. This Special Edition of Biomedicines, “Therapeutic Potential for Cannabis and Cannabinoids”, was dedicated to providing evidence for the medicinal value of cannabis to treat human illness and disease. Topics included, but were not limited to, preclinical animal models examining the efficacy of cannabis and cannabinoid derivatives on pain, anxiety, cancer, and other diseases; and cell and molecular models of cannabinoid pharmacokinetics, drug–drug interactions, and disease treatment. These studies are of great importance not only for progressing the cannabis field, but also for validating the use of cannabis and cannabinoids as therapeutics
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 100
    Online Resource
    Online Resource
    Marine Natural Products as Anticancer Agents 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575681 , 9783036575698
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents
    Note: English
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
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