ISBN:
9781351261760
,
9780815365327
,
9780367656997
Language:
Undetermined
Pages:
1 Online-Ressource
Series Statement:
Oxidative Stress and Disease
Keywords:
Pre-clinical medicine: basic sciences
;
Cellular biology (cytology)
;
Molecular biology
;
Biology, life sciences
;
Protein Tyrosine Phosphatase 1B,LMW Thiol,GPx4 Expression,Active Site Cysteine,GPx1 mRNA,Thiol Disulfide Exchange Reactions,FeS Clusters,GCL Activity,GPx1 KO,GPx1 Activity,Mixed Disulfide,Iron Sulfur Clusters,Labile Iron Pool,Thiol Disulfide Oxidoreductases,GCLC Expression,Total GSH Content,GSH Transport,GSH Synthesis,BLM.,Iron Dependent Lipid Peroxidation,Mitochondrial GSH,Renal Proximal Tubular Cells,Free GSH,Dual Specificity Protein Phosphatase,PT,Biosynthesis,Adaptive Stress Response,Detoxification,Redox Reactions,Drug Discovery,Henry J. Forman,Hongqiao Zhang,Terrance J. Kavanagh,Lawrence H. Lash,Laura Orian,Giorgio Cozza,Matilde Maiorino,Stefano Toppo,Fulvio Ursini,Diane E. Handy,Joseph Loscalzo,Holger Steinbrenner,Lars-Oliver Klotz,Anna P. Kipp,Antonella Roveri,José Pedro,Friedmann Angeli,Valerian E. Kagan,Marcus Conrad,Yefim Manevich,Lutz Schomburg,Bengt Mannervik,Birgitta Sjödin,Kenneth D. Tew,Ralf Morgenstern,Jesper Z. Haeggström,Per-Johan Jakobsson,Leopold Flohé,Iain L. O. Buxton,Scott D. Barnett,Linda Liedgens,Marcel Deponte,Carsten Berndt,Anna Dorothee Engelke,Klaudia Lepka,Lars Bräutigam,Marcelo A. Comini,Martin Hugo,Madia Trujillo,Lucía Piacenza,Rafael Radi,Leonardo Astolfi Rosado,BrandPedre,Joris Messens,Quach Ngoc Tung,Nico Linzner,Vu Van Loi,Haike Antelmann
Abstract:
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione--transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
Note:
English
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