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  • MPI Ethno. Forsch.  (416)
  • Würzburg UB
  • Basel : MDPI - Multidisciplinary Digital Publishing Institute  (416)
  • Paris : OECD
  • Medicine  (416)
Datasource
  • MPI Ethno. Forsch.  (416)
  • Würzburg UB
Material
Language
Years
Author, Corporation
Publisher
Keywords
  • 1
    Online Resource
    Online Resource
    Solving the Puzzle: Molecular Research in Inflammatory Bowel Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036598642 , 9783036598635
    Language: Undetermined
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Medicine ; inflammatory bowel diseases ; cell autofluorescence ; immune cells ; NADH ; FAD ; flow cytometry ; multiphoton microscopy ; colitis ; colitis-associated cancer ; inflammatory bowel disease ; colorectal cancer ; colon adenocarcinoma ; ulcerative colitis ; Crohn’s disease ; cDNA microarray ; transciptomics analysis ; microarray ; inflammatory bowel diseases (IBDs) ; vasculature ; angiogenesis ; gut vascular barrier ; vessel permeability ; epithelial barrier ; homeostasis ; acetylcholine ; muscarinic receptor ; non-neuronal acetylcholine ; mucosal wound healing ; ferroptosis ; leaky gut ; inflammatory bowel disease (IBD) ; triple-culture ; Caco-2 ; HT29-MTX-E12 ; THP-1 ; monocyte-derived macrophage ; inflammation ; TEER ; FITC-dextran 4 kDa (FD4) ; pro-inflammatory cytokines ; HIF-1α ; PHD2 ; AKT ; intestinal epithelial cells ; probiotics ; LPS ; antigen-specific T-cells ; celiac disease ; gliadin ; IBD ; food antigens ; intestinal Behcet’s disease ; immune mechanism ; biological agents ; claudin ; tight junctions ; barrier function ; gut ; ZO-1 ; actin ; cell migration ; cell division ; colon cancer ; PMNs ; LDs ; FOXO3 ; n/a
    Abstract: Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn’s disease (CD), sharing similarities but exhibiting distinct differences, sometimes making their discrimination challenging.A prominent feature of IBD is the inflammation of the intestinal mucosa, characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity, leading to a phenomenon known as “leaky gut.” Inflammation can manifest acutely or chronically, known as relapsing, and can increase in severity over time, thereby causing life-long morbidities and reduced quality of life for affected individuals, underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression
    Note: English
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  • 2
    Online Resource
    Online Resource
    Diagnosis, Evaluation, and Management of Diseases during Pregnancy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036597386 , 9783036597393
    Language: Undetermined
    Pages: 1 Online-Ressource (342 p.)
    Keywords: Medicine ; pregnancy ; fetus prenatal care ; high-risk ; pathology
    Abstract: This reprint includes studies on diagnosing, evaluating and managing the pathologies diagnosed during pregnancy. The information provided in these pages is helpful for specialists in obstetrics and gynaecology but also for other medical specialities involved in treating pregnant women with associated pathologies. Studying the articles in the reprint could contribute to improving case management
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  • 3
    Online Resource
    Online Resource
    Neural Frontiers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036597645 , 9783036597652
    Language: Undetermined
    Pages: 1 Online-Ressource (528 p.)
    Keywords: Medicine and Nursing ; Neurology and clinical neurophysiology ; Medicine
    Abstract: undefined
    Note: English
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  • 4
    Online Resource
    Online Resource
    Hydrogen Bonds (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567709 , 9783036567716
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine
    Abstract: This reprint is excellent proof that, despite more than a hundred years of research into hydrogen bonds, they are still an interesting and fundamental topic in the natural sciences. The collected articles deal with various aspects of the existence of hydrogen bonds and show human ingenuity in the field of inventing and applying various techniques, both experimental and theoretical, in order to describe them more fully
    Note: English
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  • 5
    Online Resource
    Online Resource
    Corrosion Properties and Mechanism of Steels (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564043 , 9783036564050
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint aims to promote and disseminate applied research in the field of corrosion of steel structures and technological equipment. Within the text, the focus is firmly placed on the detailed study of corrosion processes affected by specific environments, as well as on the effects of corrosion damage on the reliability and service life of structural components and technological equipment. Special attention is paid to the study of the impact of corrosion processes on pipelines
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  • 6
    Online Resource
    Online Resource
    Advances in Industrial Robotics and Intelligent Systems (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565545 , 9783036565552
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Robotics and intelligent systems are key technologies to promote efficient and innovative applications in the most diverse domains (industry, healthcare, agriculture, construction, mobility, etc.), performing and supporting activities that are not suitable to be performed by humans. Such activities are frequently time-consuming, repetitive tasks with low added value, which are physically demanding and/or dangerous. Nevertheless, robotics and intelligent systems face several scientific and technological challenges related to their integration and interoperability with other systems, safety, flexibility, re-configurability and autonomy. These challenges are especially relevant when robots operate in real unstructured environments and share a workspace with humans and other equipment. This reprint collects research achievements, ideas, and applications regarding advanced intelligent robotic systems, covering diverse technologies and application domains. Generically, the contributions cover optimal path-planning strategies and innovative designs for mobile manipulators, the integration of robotic and intelligent systems, grasping, manipulation, teleoperation, haptics, user experience approaches for collaborative robots, and multi-agent systems
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  • 7
    Online Resource
    Online Resource
    Development of Laser Welding and Surface Treatment of Metals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567013 , 9783036567006
    Language: Undetermined
    Pages: 1 Online-Ressource (420 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Constant striving to reduce pollutant emissions, greenhouse gases and energy consumption, i.e., sustainable development, forces the development of new and improved materials, technologies and manufacturing processes. One of the areas of sustainable development of the global economy is also the development of laser devices and the spreading of laser technology applications.The book deals with important issues related to the development of science and technology in the field of application the laser beam for joining, surface treatment, coatings. However, the thematic scope is not limited only to mentioned issues. The scope of the book covers issues related to advances in computational modelling of heat sources in laser and arc processes, unique techniques of underwater welding or unique techniques of forced cooling the weld metal under solidification during arc welding or hybrid process of laser deposition under cryogenic conditions, microstructural and mechanical characterisation of coatings and joints produced by different welding technologies. The above book contains valuable information, both theoretical and practical research results in the field of advanced technologies of joining, surface treatment and coatings, quality control and assessment, as well as management of the technological processes. Therefore, I deeply believe that the book will be a valuable and helpful for young scientists, engineers, and students in the field of welding and surface engineering, materials science, and manufacturing engineering
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  • 8
    Online Resource
    Online Resource
    Plant and Marine-Derived Natural Product Research in Drug Discovery: Strengths and Perspective (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568119 , 9783036568102
    Language: Undetermined
    Pages: 1 Online-Ressource (346 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: For centuries, nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays, natural-based treatments continue to be employed for primary health care, particularly playing a significant role in folk medicine. In addition, we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources, making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment, we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research, contributing to the scientific validation of their use and opening new perspectives in drug discovery
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  • 9
    Online Resource
    Online Resource
    High Performance Computing Serving Atmospheric Transport & Dispersion Modelling (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565811 , 9783036565804
    Language: Undetermined
    Pages: 1 Online-Ressource (304 p.)
    Keywords: Medicine
    Abstract: This reprint brings together fifteen articles published in the Special Issue of the journal Atmosphere, entitled “High-Performance Computing Serving Atmospheric Transport & Dispersion Modelling”. These articles cover a wide variety of topics related to air quality in urban areas and nature-based solutions to improve it in the context of climate change; impact studies on human health and the environment of facilities and infrastructure projects as well as risk studies; the assessment of emerging threats; and preparations for and responses to emergencies involving toxic, flammable, or explosive atmospheric releases. As the fifteen articles presented here remarkably illustrate, what these contemporary topics have in common is the implementation of multi-scale simulations of atmospheric transport and dispersion by means of physical models of computational fluid dynamics (CFDs), whose potential is enhanced by high-performance computing (HPC). This reprint thus addresses the answers provided by modelling and the most advanced simulations to some societal matters of major interest
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  • 10
    Online Resource
    Online Resource
    Food Bioactive Compounds: Chemical Challenges and Opportunities (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567938 , 9783036567921
    Language: Undetermined
    Pages: 1 Online-Ressource (426 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In recent years, there has been a growing need for both nutritional and healthy foods with superior functional properties. In this line, bioactive compounds are economically available in different foods systems with limitations in quality and functionality.The present Special Issue is placed in this context, and aimed to provide a collection of modern chemical strategies developed with the intent of extracting, characterizing, tracing, or authenticating food bioactive compounds. Original research articles dealing with innovative techniques for the extraction (e.g., green chemistry) of bioactive compounds were welcomed. In addition, when discussing modern analytical methods, the structural characterization and identification of these active components were required. Attention was also devoted to theoretical aspects of the determination of the bioactivity and mechanisms of action of food bioactive compounds, as well as challenging properties for application as drug agents. Review articles providing an overview of the latest trends in this area of interest were also very welcomed
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  • 11
    Online Resource
    Online Resource
    Innovative Robot Designs and Approaches (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567143 , 9783036567150
    Language: Undetermined
    Pages: 1 Online-Ressource (252 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint aims to disseminate the latest research achievements, findings, and ideas in the robotics field, with particular focus on the Italian scenario. It covers a range of topics related to the theory, design, practice, and applications of robots, such as robot design and kinematics, dynamics of robots and multi-body systems, linkages and manipulators, control of robotic systems, trajectory planning and optimization, innovative robots and applications, industrial robotics, collaborative robotics, medical robotics, assistive robotics, and service robotics. The reprints contributions include (but are not limited to) revised and substantially extended versions of selected papers that were presented at the 2nd International Conference of IFToMM, Italy (IFIT 2018)
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  • 12
    Online Resource
    Online Resource
    Robotic Non-destructive Testing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565293 , 9783036565309
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine
    Abstract: Non-destructive testing and evaluation are commonly referred to as the vast group of analysis techniques used in civil, medical, and industrial sectors to evaluate the properties of materials, tissues, components, or structures, without causing any damage. Automation offers many benefits for non-destructive testing to cope with increasing demands, including improved reliability and higher inspection speeds. Additionally, robots enable inspections in locations that are not easily accessible to human operators and allow for humans to be removed from potentially dangerous environments. However, the perceived complexity and high costs have limited the adoption of automation. As a result, the full potential that could be derived from the seamless integration of robotic platforms with sensors, actuators, and software has not been fully explored; it could still revolutionise the way that automated inspections are performed and conceived. The recent advancements in electronics, robotics, sensor technology and software pave the way for new developments in automated testing and data-driven autonomous robotic inspections in several sectors. This Special Issue aimed to attract the latest research outcomes in the field of robotic sensing. Five papers relate to inspection systems based on robotic fixed-base manipulators, three of which are associated with in-process inspection in manufacturing applications (robotic wire-arc welding and additive manufacturing). Four papers report research advancements in mobile robotic-enabled sensing
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  • 13
    Online Resource
    Online Resource
    Innovative Pasta with High Nutritional and Health Potential (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567488 , 9783036567495
    Language: Undetermined
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medicine ; Mental health services
    Abstract: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta
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  • 14
    Online Resource
    Online Resource
    Emerging Materials for Additive Manufacturing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566429 , 9783036566436
    Language: Undetermined
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medicine ; Oncology
    Abstract: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM
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  • 15
    Online Resource
    Online Resource
    Integrated Energy Systems towards Carbon Neutrality (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568058 , 9783036568041
    Language: Undetermined
    Pages: 1 Online-Ressource (256 p.)
    Keywords: Medicine ; Oncology
    Abstract: Energy systems have played an essential role in the history of human civilization. As our civilization evolves, energy systems are expected to adapt to the environment and desire of people for more sustainable development whilst meeting the ever-increasing energy demand of society. To address global warming and its threats to sustainable development to multiple ends, major economies around the world have announced low-carbon, carbon-neutral, or negative-carbon development targets. To meet these goals, the energy systems as we know them today need to undergo substantial structural changes in terms of the way primary energy is extracted from nature, converted to secondary energy, transmitted from conversion sites to end use, and shifted between time slots to coordinate supply and demand. The share of renewable and fossil energy in the overall energy portfolio could experience unprecedented structural change of a kind not witnessed since industrialization. To cope with this harsh transition, energy systems should be planned, designed, retrofitted, and operated in a revolutionary manner.This reprint aims to present the most recent advances in energy systems analysis towards low/zero/negative carbon emission targets via integration amongst different primary energy supplies, between multiple energy supplies and demands, across geographically separated regions, and over different time scales from seconds to seasons
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  • 16
    Online Resource
    Online Resource
    Ventilation and Indoor Air Quality (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559810 , 9783036559827
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: This reprint focuses on the application of ventilation and indoor air quality (IAQ) in different settings, and is centred around different indoor environments and policymaking issues. It also explores how issues around health, IAQ and ventilation have evolved through the COVID-19 crisis. In connection with the growing need to determine and assess IAQ, new research seeks to test and investigate new methodologies based on research topics which include an increasing number of harmful substances and test methods. Ventilation and Indoor Air Quality ultimately aims to provide the reader with a comprehensive range of case studies, seeking to solve ventilation and IAQ issues from different perspectives. It presents 19 chapters related to regulations, homes, modelling, field studies, and technology related to ventilation and IAQ. Overall, this reprint provides state-of-the-art analysis and reviews so that readers with any level of prior knowledge of ventilation and IAQ are introduced to the latest research on these issues. This reprint was written to inspire and stimulate the development of further multidisciplinary research on IAQ issues
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  • 17
    Online Resource
    Online Resource
    Advances in Remediation of Environmental Pollutants for Sustainable Development (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566030 , 9783036566023
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine
    Abstract: Environmental quality is crucial to our health, economy, lives, and for future generations. However, during the last few years, we have faced several serious challenges, which include, but are not limited to, climate change, unsustainable consumption and production, as well as various forms of pollution. These challenges are of global concerns for the sustainable development of human beings. This reprint has collected review and research papers aimed at a wide range of environmental topics: water and wastewater treatment and management, soil degradation and conservation, pollution control, the environmental impact of technologies, air quality and the indoor environment, and advanced environmental materials. Analytical methods developed for the determination of environmental pollutants were also welcomed. Papers dealing in the synthesis of adsorbents for the solid-phase extraction of environmental pollutants also fell within the scope of this Special Issue. Contributions describing novel and significant knowledge, scientific results, and advanced applications in the field of environmental sciences and technology were also welcomed. This reprint provides an integrated view of the trends in solving the problems associated with the achievement of sustainability in environmental technology
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  • 18
    Online Resource
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    Osteoporosis and Related Bone Metabolic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563480 , 9783036563497
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Many heterogeneous causes (e.g., metabolic, inflammatory, autoimmune, vascular, and renal diseases, and even drugs), collectively grouped as secondary causes of osteoporosis, may lead to bone loss or damage to architecture through a number of mechanisms. Although these secondary causes of osteoporosis are the most frequently observed causes of unexpected bone loss, they can only be diagnosed via a high degree of suspicion and clinical experience and by performing the appropriate investigations. In inflammatory disorders such as rheumatoid arthritis or chronic inflammatory bowel diseases, as well as vascular diseases, T-cell activation, and consequently pro-inflammatory cascades, trigger the increased expression of T-cell-derived RANKL. In addition, a new biomarker signature of bone-related miRNAs is promising in certain clinical features. Glucocorticoids, often used to control disease activity, decrease the number and function of osteoblasts and inhibit OPG expression. The ubiquitous occurrence of disease-related secondary changes in bone metabolism implies that numerous medical disciplines need to interact. Screening for secondary causes of osteoporosis and the search for new modes of action should present a substantial aspect of osteoporosis management. In the book, the current management of osteoporosis and related metabolic bone diseases is discussed
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  • 19
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    Molecular Biology of Disease Vectors (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566979 , 9783036566962
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Oncology
    Abstract: Arthropod disease vectors transmit not only serious diseases, such as malaria, but many other diseases as well, many of which are neglected to various extents. In most cases, a tripartite interaction is involved between the arthropod disease vector, the vertebrate host, and the vector-borne pathogens. The reprint aims to present a selection of the latest data (and up to date information in the case of reviews) about the molecular and biochemical events that mediate this tripartite interaction with emphasis on ticks and mosquitoes
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  • 20
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    Artisanal and Small-Scale Gold Mining (ASGM) Related Environmental and Health Problems (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568706 , 9783036568713
    Language: Undetermined
    Pages: 1 Online-Ressource (360 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint focuses on artisanal and small-scale gold mining (ASGM) all over the world, as well as its impact on the economy, environment, and health, providing sustainable solutions to severe ASGM problems. This book presents a total of 20 published articles of regions including Southeast Asia, South America, and South Africa, as well as a general overview of ASGM issues. Studies included in this book posit that (1) ASGM activity is still widely practiced as an alternative livelihood in rural areas in many countries around the world, using toxic elements such as Hg and cyanide due to a lack of legal enforcement on the ASGM sector; (2) ASGM has a negative impact on environmental ecosystems, causes occupational health problems for miners, and causes chronic health disorders in both ASGM communities and those living far from ASGM areas. However, some studies propose that specific potential bioindicators could be used to monitor the environment and health of those living in ASGM communities, providing sustainable solutions to severe ASGM problems
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  • 21
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    Probability and Stochastic Processes with Applications to Communications, Systems and Networks (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564852 , 9783036564869
    Language: Undetermined
    Pages: 1 Online-Ressource (182 p.)
    Keywords: Medicine
    Abstract: The present reprint contains all of the articles accepted and published in the Special Issue "Probability and Stochastic Processes with Applications to Communications, Systems and Networks" from the MDPI Mathematics journal. This Special Issue is devoted to probability, statistics, stochastic processes and their different applications in system and network analysis. The Special Issue includes works related to the analysis and applications of different queuing models, which begin with general approaches in modeling queuing systems and networks; an analysis of probabilistic and statistical methods in telecommunication; an asymptotic analysis of queuing networks in the condition of a large load; general complex networks and their structures, e.g., topology and graph theory; mathematical methods and models in smart cities; exclusive statistical methods, such as statistical estimates in bio/ecology, medicine and neural networks; and studies that estimate parameters in complex technical systems, etc. We hope that the scientific results collected in this reprint will help foster future research related to probability, stochastic processes and their applications
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  • 22
    Online Resource
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    Land Use/Land Cover and Natural Hazards: Interactions, Changes, and Impacts (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567389 , 9783036567396
    Language: Undetermined
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint focuses on land use/land cover (LULC), natural hazards and their interactions, changes, and impacts. Over the past few decades, the risks due to natural hazards have increased significantly, to a large extent due to changes in LULC, which are triggered mainly by anthropic pressure on landscapes, i.e., urbanization, forest management practices, agricultural practices, and the like. As a result, LULC changes contribute significantly to changes in the variability or magnitude of natural hazards, such as floods, landslides, and erosion. Therefore, this reprint provides a collection of studies focused on the interactions between LULC and different types of natural hazards, which were studied in several research areas around the world
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  • 23
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    Implementation of Chemometrics and Other Techniques as Means of Authenticity and Traceability to Detect Adulteration in Foods for the Protection of Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566610 , 9783036566603
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: Authenticity and traceability are crucial in order to overcome frauds in the international food trade. Control measures are perceived as the greatest vulnerability in the food supply chain. In order to decrease contribution to the overall perceived fraud vulnerability, analytical approaches and chemometrics are usually employed
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    Ecosystem Observation, Simulation and Assessment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567747 , 9783036567754
    Language: Undetermined
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on ecosystem observation, simulation and assessment. Ecosystems provide supply, regulation, culture and support services for human beings in addition to overall support human survival and sustainable development. However, driven by multiple factors such as climate change, population growth, urbanization, and exploitation of mineral resources, global problems such as ecosystem degradation and biodiversity loss have affected the sustainable development of human beings. Because of this, it has become a hot spot in ecology research to develop basic theories, model methods and technical means for ecosystem observation, simulation and evaluation for the quantitative analysis of the structure, process and function of ecosystems as well as the improvement of the scientific understanding of the changing characteristics and evolution laws of natural ecosystems
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    Methodologies Used in Remote Sensing Data Analysis and Remote Sensors for Precision Agriculture (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566146 , 9783036566153
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medicine
    Abstract: When adopting remote sensing techniques in precision agriculture, there are two main areas to consider: data acquisition and data analysis methodologies. Imagery and remote sensor data collected using different platforms provide a variety of information volumes and formats. For example, recent research in precision agriculture has used multispectral images from different platforms, such as satellites, airborne, and, most recently, drones. These images have been used for various analyses, from the detection of pests and diseases, growth, and water status of crops to yield estimations. However, accurately detecting specific biotic or abiotic stresses requires a narrow range of spectral information to be analyzed for each application. In data analysis, the volume and complexity of data formats obtained using the latest technologies in remote sensing (e.g., a cube of data for hyperspectral imagery) demands complex data processing systems and data analysis using multiple inputs to estimate specific categorical or numerical targets. New and emerging methodologies within artificial intelligence, such as machine learning and deep learning, have enabled us to deal with these increasing data volumes and the analysis complexity
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    Radioactive Pollution and Biological Effects of Radioactivity (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567679 , 9783036567662
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: The Special Issue “Radioactive Pollution and Biological Effects of Radioactivity“of the Journal Life involved the participation of academic scientists, researchers, and scholars from all over the World that contributed with articles, reviews, and case reports, based on high-quality research works.The common topic of the published works concerns the radioactive pollution, which occurs when radioactive elements enter the atmosphere and reach the Earth’s surface, within solids, liquids, or gases, including the human body. This happens after natural and/or man-made activities, such as nuclear tests, industrial waste (e.g., radiodiagnostics), and excesses of naturally occurring radioactive sources. This kind of pollution entails risks of radiological contamination of the environment, with harmful effects on human health caused by the ionizing radiation. This theme has become even more current due to the increasing use of ionizing radiation for domestic, industrial, and medical purposes during the last century. Radiological monitoring is a primary objective of radiation protection in order to estimate and understand the impact of radionuclides on the environment and to assess the health risk for the population.The aim of the Special Issue has been to provide an interdisciplinary platform for researchers to exchange and share their experiences and latest achievements on all aspects of radioactive pollution. Survey data analysis, original and unpublished results of conceptual, constructive, empirical, experimental, and theoretical work were welcome, as well as other concepts related to the radiation field
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    Polymer-Based Biomaterials and Tissue Engineering (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036582375 , 9783036582368
    Language: Undetermined
    Pages: 1 Online-Ressource (190 p.)
    Keywords: Medicine
    Abstract: Polymers in the form of films, fibers, nano- and microspheres, composites, and porous supports are promising biomaterials for a wide range of advanced biomedical applications. This Special Issue presents novel studies and new approaches in the field of biomaterials for tissue engineering and drug delivery. It includes seven original research articles and two reviews on biomaterials based on polymeric matrices with various structures, including porous composites, nanofibrous scaffolds, meshes, and hydrogels, which can include micro- or nanoparticles (graphene nanosheets, bioactive glass, and hydroxyapatite and halloysite nanotubes)
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    Dietary Curcumin and Health Effects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036560878 , 9783036560885
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The Special Issue provides twelve contributions, of which three original articles, seven narrative reviews, one systematic review, and one meta-analysis that, altogether, offer a multifaceted and multidisciplinary overview that allows to draw a picture as intriguing and fascinating as possible on the benefits of curcumin and also to suggest potential fields of activities still to be explored. Among the biological activities exerted by curcumin, the anti-oxidative and anti-inflammatory properties reported in many studies make it a potential effective tool in preventing and counteracting chronic-degenerative diseases, very often associated with obesity and aging, such as cardiovascular diseases, T2D, metabolic dysfunctions, neurodegenerative diseases, and cancer, all of them characterized by the presence of oxidative and inflammatory processes. The main concerns that arise from the evaluation of the preventive/therapeutic effects of curcumin are, first of all, the still small number of randomized placebo-control studies available; in addition, small sample sizes have generally been considered, and different protocols and different formulations as well as different routes of administration of curcumin have been used. Thus, it is quite difficult to compare the results and to provide a standard protocol for the use of this promising natural compound. For these reasons, and taking in account the growing use of curcumin by the general population, further investigations to confirm and expand current findings are mandatory and research on curcumin and its effects on human health have to be fostered and promoted
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    Stabilization and Resuscitation of Newborns (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564470 , 9783036564463
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine
    Abstract: The majority of newborns do not need medical interventions to manage the neonatal transition after birth. However, every year millions of newborns worldwide require respiratory support immediately after birth, and another considerable number of newborns additionally require extensive resuscitation including chest compressions and drug administration. Despite a significant increase in knowledge and development of enhanced therapy strategies over the past few years, morbidity and mortality caused by failures in neonatal transition remain an important health issue. The purpose of this reprint is to support or introduce novel concepts and add information in the area of the “Stabilization and Resuscitation of Newborns”, aiming to improve neonatal care and, as the major objective, to enhance neuro-developmental outcomes
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    Clinical Features and Long-Term Outcomes of Systemic Lupus Erythematosus (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561103 , 9783036561097
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The clinical spectrum of systemic lupus erythematosus (SLE) is highly heterogeneous, ranging from mild disease, which can be limited to skin and joint involvement, to life-threatening conditions with renal impairment, severe cytopenias, central nervous system disease, and thromboembolic events. Apart from the host genetics, several environmental factors, such as sunlight, infections, drugs, and probably hormonal factors, can trigger the onset of symptoms related to SLE. Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE still have significant rates of premature mortality and many patients experience severe disease with increased risk of sustaining organ damage and having a reduced health-related quality of life. The development of effective drugs that can induce remission or low disease activity, the unanimous use of definitions of remission and low or high disease activity, flare, and response to therapy, the identification of non-invasive biomarkers of disease activity and long-term outcomes, and the implementation of SLE patients’ perspectives as an integral part of the clinical assessment constitute only a few of the many unmet needs in the field of SLE
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    In Silico Strategies for Prospective Drug Repositionings (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561349 , 9783036561332
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions
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    Detection, Control and Contamination of Mycotoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563503 , 9783036563510
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The objective of this collection is to illustrate the most recent research on the development of novel and/or rapid methods for mycotoxin determination, and to propose new strategies for monitoring and/or reducing mycotoxin contamination. Innovative sample preparation techniques or protocols and the possibility of multiclass mycotoxin detection will be very positively considered for possible inclusion in this Special Issue. Both methods based on (bio)sensors and chromatography with various detectors (including mass spectrometry) are welcome. Applications of already published methods on new matrices without any modification will not be accepted. However, extensive studies and monitoring on the spread of contamination through the food production chain could be of interest for this collection
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    3D Printed Materials Dentistry (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568881 , 9783036568898
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine ; Pharmacology ; Research & information: general ; Chemistry
    Abstract: The Special Issue reprint covers a wide range of applications of 3D-printing in dentistry. Five out of eleven research papers deal with applications of 3D printing in orthodontics, one study presents a 3D-printed fitting system for the FFP2 that were applied during the COVID-19 pandemic, and the others address applications in prosthodontics and restorative dentistry
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570419 , 9783036570402
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy
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    Personalized and Precision Medicine 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570457 , 9783036570440
    Language: Undetermined
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Medicine
    Abstract: This reprint, guest edited by Anne-Marie Caminade, gives an impressionist overview of the current state of the art about “Personalized and Precision Medicine”. Twenty contributions illustrate the diversity of the topic, including new approaches about cancers, neurodegenerative diseases, infectious diseases, lungs obstruction, skeletal diseases, intestinal microbiomes, new tools such as ultra-high-frequency ultrasound or non-oncological radiotherapy, and a new class of drugs (dendrimers). This reprint is an illustration of the present and future impact of Personalized and Precision Medicine on all the therapeutic domains
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    Nutritional Support for Chronic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570624 , 9783036570631
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Medicine
    Abstract: Diet contributes to the development of many chronic conditions including obesity, cardiovascular disease, hypertension, stroke, type 2 diabetes, metabolic syndrome, some cancers, non-alcoholic fatty liver disease, and potentially some neurological diseases. This reprint addresses associations between diet (and specific nutrients including vitamin D) and various chronic diseases including obesity, cardiovascular disease, hypertension, stroke, diabetes, metabolic syndrome, non-alcoholic fatty liver disease, neurological conditions, and age-related macular degeneration. More specifically, the impacts of plant-based diets, dairy products, and ketogenic diets are explored in relation to chronic disease risk as well as some benefits of the consumption of oral nutritional supplements in the prevention of malnutrition and sarcopenia and in the treatment of wounds in individuals with diabetes. Additional topics that are covered include some roles of the fatty acid arachidonic acid in the body and the impact of cellular mitochondrial dysfunction on the progression of age-related macular degeneration. The effectiveness of a variety of nutraceuticals is covered as a means for the prevention or treatment of age-related macular degeneration. Lastly, the use of olive oil in reducing gut permeability in those with pre-diabetes is addressed, as well as the complex relationships of diet/food and of disease (metabolic syndrome) with the gut microbiota
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    Biomarkers of Stress in Companion Animals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571249 , 9783036571256
    Language: Undetermined
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Medicine
    Abstract: The welfare of an individual could be severely affected by stressful events. Mainly for this reason, the scientific community is interested in finding specific and quantifiable characteristics which could indicate or predict specific signs of acute or chronic stress exposure. The aim of this reprint is to reflect this interest in the field of companion animal physiology. The authors engaged in publishing this reprint are experts in the multiple mechanisms involved in stress response, including the detection of behavioral and physical signs which can be measured through biological indicators of homeostasis displacement. The editors strongly believe this topic will be of interest not only to researchers in this field, but also to dog trainers, dog shelter workers and veterinary behaviorists
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    Dietary Intake and Chronic Disease Prevention (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036573090 , 9783036573083
    Language: Undetermined
    Pages: 1 Online-Ressource (292 p.)
    Keywords: Medicine
    Abstract: This reprint describes how lifestyle changes can impact the incidence and progression of chronic non-communicable diseases. In this context, regular physical activity and heathy nutritional habits are very important. Moreover, natural bioactive compounds could represent a new adjuvant therapy in the clinical management of these pathological conditions
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    Functional Foods as a New Therapeutic Strategy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577081 , 9783036577098
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases
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    The Role of Toll-Like Receptors (TLR) in Infection and Inflammation (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576152 , 9783036576145
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: Toll-like receptors (TLRs) represent a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for the induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental, leading to hyper-inflammation, sepsis, and loss of tissue integrity. The involvement of TLRs in inflammation and bacterial infection has been recognized for a long time. There is an increasing number of reports demonstrating the involvement of TLR activation in a variety of viral infections, associated with protective immunity, but also immune hyper activation and even viral replication. Recent data show the involvement of TLR activation in various acute respiratory viral infections, including SARS-CoV-2 and indicate an essential role in COVID-19 pathology. It aimed to gather newest data and hypotheses regarding molecular and cellular mechanisms of TLR triggering and activation and their downstream signaling pathways by viral infections, and their correlation to immunology and pathophysiology of the associated diseases, to facilitate translational research resulting in new targets for the treatment of viral infectious diseases including COVID-19
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    Orthopedics and Trauma in Children (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036576954 , 9783036576947
    Language: Undetermined
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Medicine
    Abstract: Discover the complexities of pediatric orthopedics in this comprehensive reprint book. Pediatric orthopedics present unique challenges in diagnosis and treatment, necessitating the expertise of skilled specialists. Congenital, developmental, and acquired orthopedic issues, including infectious, neuromuscular, nutritional, neoplastic, psychogenic, and traumatic conditions, are explored. With a focus on evidence-based recommendations, this book addresses the management of orthopedic deformities in children by considering different clinical scenarios. From upper and lower limb injuries to severe trauma, readers will gain insights into decision-making processes for reconstruction or amputation. As a valuable resource for orthopedic surgeons, pediatricians, and healthcare professionals, this reprint fills knowledge gaps to optimize patient care
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    Translational Aspects of Cardiovascular Biology : From Bench to Bedside (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575759 , 9783036575742
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint, edited by Prof. Gaetano Santulli, MD, PhD, collects the most up-to-date peer-reviewed scientific papers dealing with cardiovascular medicine, from basic science to pre-clinical and clinical investigations, highlighting the fundamental importance of translational medicine in the challenging quest for new therapies to cure cardiovascular disease. Indeed, cardiovascular disease is the leading cause of death worldwide, and the search for novel mechanisms and therapeutics is desperately needed. Therefore, both basic and translational studies in the cardiovascular field represent a paramount strategy to identify novel therapeutic targets and improve the quality of life of patients with cardiovascular disorders
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    Optic Neuropathies : Current and Future Strategies for Optic Nerve Protection and Repair (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575056 , 9783036575049
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine
    Abstract: Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma
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    Neuroscience, Neurophysiology and Symmetry (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574783 , 9783036574790
    Language: Undetermined
    Pages: 1 Online-Ressource (90 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: This reprint focuses on fundamental and applied research on asymmetry of movement and postural balance and underlying functions in humans. Experimental protocols based on kinetic, kinematic, radiological, functional magnetic resonance imaging and transcranial Doppler ultrasound data taken from healthy, young, elderly and pathological individuals provide new insights into asymmetry in human movement and posture and are presented in the Special Issue
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    Oncogenic Signaling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573373 , 9783036573366
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Oncology
    Abstract: At the molecular level, the activation of growth factor receptors (GFRs) induces a mitogenic response and maintains cancer cell growth. The majority of malignant diseases are related to aberrant intra- and intercellular communication, associated with the GFR-mediated pathways. Moreover, the evasion of apoptotic signals and the requirement of angiogenesis were also found to be of fundamental importance for tumor progression and metastasis. In this context, a high expression of GFRs aids blood vessel formation, cell migration, and the inhibition of apoptosis. GFR-directed therapy that would theoretically selectively kill malignant cells and reduce the toxicity associated with nonselective conventional chemotherapy may be a promising treatment for cancer. Many intracellular proteins involved in GFR signal transduction can also function as oncogenes. Mutations affecting key proteins in the RAS/MAPK and PI3K/AKT pathways are known to be crucial in maintaining the malignancy of different types of cancers. This information has guided the development of compounds designed to target one or more of these pathways in cancer cells. Even though there have been important advances in our understanding of GFRs and their signaling, certain essential information is still lacking, and these membrane receptors are still being laboriously studied by several research groups, to find therapeutic solutions to unmet medical needs
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    Diabetology: Feature Papers 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572567 , 9783036572574
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue “Diabetology: Feature Papers 2022” has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities
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    New Insights into Contraception (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572765 , 9783036572772
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine
    Abstract: Today, a great variety of contraceptive techniques are available to women; this, coupled with improving the educational levels of female children and adults, is hastening a decline in fertility and consequently, population growth. With the advent of sustained fertility rates lower than replacement levels in many countries, including China and India, we are already witnessing major economic, social, environmental, and geopolitical consequences. Given this situation, today, the promotion of the use of contraception means improving health, not demography, placing emphasis on individuals and not just on methods alone; on the quality of services, and not simply on availability. Indeed, there is an increasing awareness that contraception can help women reduce health risks that are associated with reproductive events and specifically, with unwanted pregnancies. This means that, no matter how ideal a method may be from a purely scientific viewpoint, it must be submitted to the free, decision-making of well-informed women. To contribute to this new user-centric perspective, this reprint presents a series of articles in which technology is considered withing the broader concept of women’s health. Five articles deal with issues related to the users’ and providers’ perspectives; three discuss a modality that is receiving increasing attention, the so-called Long-Acting Reversible Contraception (LARC); and the last three contributions highlight the new advances in oral hormonal contraception
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    Environmental Exposure to Toxic Chemicals and Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572697 , 9783036572680
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors
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    Biological and Pharmacological Activity of Plant Natural Compounds III (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570617 , 9783036570600
    Language: Undetermined
    Pages: 1 Online-Ressource (304 p.)
    Keywords: Medicine
    Abstract: By joining the two previous editions, this Special Issue completes the trilogy of Special Issues entitled "Biological and Pharmacological Activity of Plant Natural Compounds", which deal with the properties and effects of phytonatural products in preclinical models. This third edition has also remained focused on their therapeutic potential, with the aim of increasing and contributing to the expansion of our scientific knowledge on plants in human health. We hope readers will enjoy this Special Issue as much as the previous publications
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    Outcomes and Therapeutic Management of Thyroid Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562636 , 9783036562643
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Globally, the impact of differentiated thyroid cancers has significantly increased in the last decade, resulting in growth of public health spending. Many international scientific societies are actively involved in the difficult process of building updated guidelines in response to scientific research, especially in the genetic and immunohistochemistry fields. The watch, wait, and see policy has added a new possibility for patients in selected cases. Considering the recognized international interest in this disease, this Special Issue aims to analyze the most recent acquisitions in terms of the diagnosis and therapy of differentiated thyroid cancer. It will offer the reader an updated point of view of the most illustrious endocrinology and endocrine-surgery international schools
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    Personalized Medicine for Parkinson's Disease : New Concepts and Future of Individualized Management (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562124 , 9783036562117
    Language: Undetermined
    Pages: 1 Online-Ressource (214 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD
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    Hepatic Encephalopathy : Clinical Challenges and Opportunities (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563381 , 9783036563398
    Language: Undetermined
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Medicine
    Abstract: Hepatic encephalopathy (HE) is a complex neurological syndrome, characteristic of patients with liver disease, that causes a wide and complex spectrum of nonspecific neurological and psychiatric manifestations, ranging from a subclinical entity such as minimal or covert hepatic encephalopathy to a deep form in which a complete alteration of consciousness can be observed: overt hepatic encephalopathy. Both minimal and overt hepatic encephalopathy have a high impact on patients, caregivers, and national health services, driving substantial consumption of economic resources. In this Special Issue, we discussed the current state-of-the-art research, address ongoing knowledge gaps, and ongoing controversies related to the pathogenesis, diagnosis, and therapeutic management of hepatic encephalopathy
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    Pediatric Fractures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561424 , 9783036561417
    Language: Undetermined
    Pages: 1 Online-Ressource (244 p.)
    Keywords: Medicine
    Abstract: This reprint contains original research and review chapters concerning the latest advancements in various topics related to pediatric fractures. Topics include fractures of the face, clavicle, shoulder, elbow, forearm, wrist, pelvis, femur, and tibia; special considerations focus on osteogenesis imperfecta patients; and consideration is also given to general pediatric fracture topics, such as the influence of the COVID-19 pandemic, mortality after pediatric trauma, the effects of NSAID and electronic cigarette use, and chapters on epidemiology and physical activity
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    Assessing Atmospheric Pollution and Its Impacts on the Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563213 , 9783036563206
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases
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    Research on Pathogenic Fungi and Mycotoxins in China (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562698 , 9783036562704
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins
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    Biomaterials for Bone Tissue Engineering 2020 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036561042 , 9783036561035
    Language: Undetermined
    Pages: 1 Online-Ressource (242 p.)
    Keywords: Medicine
    Abstract: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration
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    State of the Art in Idiopathic Pulmonary Fibrosis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036563855 , 9783036563848
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: This reprint is a compilation of ten publications, including original-research and review articles, and the accompanying editorial within the scope of a Special Issue entitled: "State of the Art in Idiopathic Pulmonary Fibrosis" published in Cells
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    Endocrine and Neuroendocrine Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036557632 , 9783036557649
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Oncology
    Abstract: Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available. This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives
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    Biomedical Imaging Technologies for Cardiovascular Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570068 , 9783036570075
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint aims to provide an update on the biomedical imaging technologies that can be used for cardiovascular diseases, including Doppler echocardiography, magnetic resonance imaging and positron emission tomography. Cardiovascular disease imaging assessment includes anatomy, hemodynamics, and tissue biomarkers, which aid the stratification of patient risk and therapy. In addition, this Special Issue includes articles that discuss the recent integration of artificial intelligence and machine learning, in order to support novel approaches to personalized image-based diagnosis
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    Artificial Intelligence in Cancer Diagnosis and Therapy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036566726 , 9783036566733
    Language: Undetermined
    Pages: 1 Online-Ressource (672 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint covers some significant impacts in the recent research in both the private and public sectors of cancer diagnosis and therapy, in which Artificial Intelligence (AI) and Machine Learning are significant. This reprint is also a collection of forty different complex and challenging problems arranged in five groups: AI in prognosis, grading, and prediction, AI in clinical image analysis, AI models for pathological diagnosis, ML and statistical models for molecular cancer diagnostics and genetics, and AI in triage, risk stratification, and screening cancer, which are all focused on using AI in cancer diagnosis and therapy. All the necessary concepts, solutions, methodologies, and references are supplied except for some fundamental knowledge that is well-known in the general fields of AI and cancer diagnosis and therapy. The readers may, therefore, gain the main concepts of each chapter, with as little of a need as possible to refer to the concepts of the other chapters and references. The readers may hence start to read one or more chapters of the book for their own interests
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    Novel Applications and Technologies for the Industrial Exploitation of Algal Derived Marine Bioactives as Nutraceuticals or Pharmaceuticals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570082 , 9783036570099
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The active molecules or bioactives (i.e., polysaccharides, fatty acids, proteins, polyphenols, diterpenes, steroids and alkaloids) from algae (seaweed and microalgae) have been widely studied in recent years for multiple pharmaceutical and nutraceutical applications. Innovative and emerging technologies, including but not limited to ultrasounds, microwaves, electric fields, high-pressure supercritical fluids, ionic fluids and plasma, are currently being explored throughout multiple stages of the pre-treatment, extraction, isolation/purification and preservation of biomolecules from algae. This Special Issue will target research papers, reviews, short communications and perspectives on the use of novel technologies for the pre-treatment, extraction, isolation‒purification, characterization and preservation of marine compounds from algae. It will particularly focus on novel research related to algal bioactives with clear and demonstrated industrial applications and focuses
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    Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570150 , 9783036570143
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medicine ; Oncology
    Abstract: Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the “one-size-fits-all” approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients
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    Multi-Functional Collagen-Based Biomaterials for Biomedical Applications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570730 , 9783036570723
    Language: Undetermined
    Pages: 1 Online-Ressource (234 p.)
    Keywords: Medicine
    Abstract: Polymeric biomaterials represent an essential tool in the biomedical field. Their high biocompatibility and ability to provide adequate regenerative support are fundamental for the development of new therapeutic devices. In particular, biomaterials derived from living organisms can exhibit not only structural roles but also several non-structural functions implicated in cellular growth, migration, and differentiation. Among them, type I collagen, a ubiquitous structural protein present in the mammalian body, plays a dominant role in maintaining the biological and structural integrity of various tissues. In recent years, with the goal of developing multi-functional collagen-based devices able to better promote the functional recovery of damaged tissues, numerous studies have focused on novel techniques and methods for the development and characterization of innovative and advanced high-performance formulations. The ability to control, modify, and tune collagen-based biomaterials performance by optimizing their architecture, besides modifying their chemistry, blending with other materials/therapeutics, or developing stimuli-responsive formulations, is an extremely important knowledge to acquire when specific multi-functionalities are sought.The present Special Issue collected 12 peer-reviewed interdisciplinary contributions on the broad topic of multi-functional collagen-based biomaterials
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    COVID-19: Current Status and Future Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567402 , 9783036567419
    Language: Undetermined
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic
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    A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569185 , 9783036569192
    Language: Undetermined
    Pages: 1 Online-Ressource (414 p.)
    Keywords: Medicine ; Physiology
    Abstract: This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology
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    The 10th International Seminar of Veterinary Medicine : Camelids in Algeria & Maghreb (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574806 , 9783036574813
    Language: Undetermined
    Pages: 1 Online-Ressource (94 p.)
    Keywords: Medicine
    Abstract: This book is a collection of articles focused on recent research covering a species which is emblematic of scientific and commercial interest—the dromedary. The dromedary economy and its sustainability are of a capital importance for the future development of humanity. This research highlights camel productions systems and rearing practices, camel biodiversity and genetics, camel breeding and feeding, dromedary pathologies, anatomy particularities in dromedary, therapeutic virtues of camel products, as well as the industry’s contribution to food security
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    Bio-Active Products from Mangrove Ecosystems (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575261 , 9783036575278
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas, between 5°N and 5°S latitudes, spanning over 118 countries. The special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for the metabolic pathway via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have taken the limelight as an attractive biodiversity hotspot, attracting significant attention from organic chemists and pharmacologists. Additionally, many unique and novel chemical structures with a wide range of structural classes have suggested various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles describing recent studies and pertinent reviews focusing on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of putting together a group of top researchers whose work we would like to feature in this collection, and we would like you to participate
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    Agricultural Products Processing and Postharvest Storage (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574165 , 9783036574172
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Agricultural products such as fruit, vegetables, and cereal are believed to be some of the most crucial sources of certain phytonutrients necessary for humans, such as vitamins, dietary fibers, and minerals. However, agricultural products are prone to quality deterioration during storage under ambient temperatures. Currently, the annual post-harvest loss rate of agricultural products can reach up to 20–30%. Owing to their perishable nature, the development of processing and preservation technologies for agricultural products is an important research topic closely associated with the national economy and people’s livelihoods that has attracted ever-increasing attention. In view of the prominent issues of high energy consumption, high costs, serious pollution, and low-quality properties in agricultural product manufacturing, our journal mainly focuses on research articles on novel techniques and the underlying mechanisms of the processing, preservation, and quality control of agricultural products, so as to promote the upgrading and updating of the agricultural product industry
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    Oxidative Stress in Parasites (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576176 , 9783036576169
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Parasitic infections pose a significant public health challenge, particularly in developing countries, and can lead to long-term illness, disability, and even death. This reprint focuses on parasitic diseases and how parasites respond to the oxidative and nitrosative stress generated by the host's immune system. The articles in this Special Issue cover various aspects of this topic, including the localization of parasites within the host, the impact of nutrition and drugs, and the role of the host's immune defense cells in the parasitic response to oxidative and nitrosative stress. Understanding the mechanisms underlying parasitic diseases is crucial for developing innovative treatments that can target parasites' defense against oxidative stress. This Special Issue serves as a valuable resource for researchers, students, and physicians interested in parasitic infections
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    Thrombolysis and Thrombectomy in Acute Ischemic Stroke (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575988 , 9783036575995
    Language: Undetermined
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke
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    Challenges and Perspectives of Neurological Disorders (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575032 , 9783036575025
    Language: Undetermined
    Pages: 1 Online-Ressource (146 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: This reprint offers a comprehensive and updated overview of the current state-of-the-art techniques in the management of various neurological disorders. These disorders include neurodegenerative diseases, neurovascular disorders, and neuro-oncological diseases. The reprint also presents the latest advances and innovations in the diagnosis, treatment, and prevention of these complex conditions, emphasizing the role of cutting-edge technologies, such as neurobiology, neuroimaging, neuroinformatics, neuropharmacology, and neurosurgery. This reprint is a useful resource for researchers, clinicians, students, and anyone interested in the current challenges and perspectives of neurological disorders
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    Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574615 , 9783036574608
    Language: Undetermined
    Pages: 1 Online-Ressource (250 p.)
    Keywords: Medicine
    Abstract: The reprint, “Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies”, provides a collection of original research articles and systematic reviews focused on diverse conditions stemming from a pathogenic single gene mutation. The articles are focused on the molecular mechanisms that are affected within a rare monogenic disorder, such as those involving gene expression, molecular pathways and cell death. Moreover, specific experimental therapies including drug discovery, drug repositioning, gene therapy and protein-based therapeutics are discussed
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    The Challenges of COVID-19 with Obesity-Related Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573519 , 9783036573502
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medicine
    Abstract: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research
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    Mental Health Challenges during the COVID-19 Pandemic (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571959 , 9783036571942
    Language: Undetermined
    Pages: 1 Online-Ressource (250 p.)
    Keywords: Medicine ; Mental health services
    Abstract: The aim of the reprint was to provide readers with updated research findings on the psychological and psychiatric consequences of the pandemic. The wide scope of the reprint reflects the complexity of the impact of the COVID-19 pandemic on mental health. The focus of the studies ranges from the psychological consequences of social distancing and the closure of schools to the neurological consequences of the viral infection, and from the stressful impact of an increased workload on frontline health workers to the unmet needs of special populations such as pregnant women, veterans and patients with neurodevelopmental disorders. Thanks to its richness in content and worldwide perspectives (contributors were from Canada, Croatia, Greece, India, Israel, Italy, Pakistan, the Philippines, Poland, Spain, and the USA), the reprint is a valuable source of information to researchers and clinicians interested in the mental health implications of the COVID-19 pandemic
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  • 75
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    Pathogenesis of Pregnancy-Related Complication (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573274 , 9783036573267
    Language: Undetermined
    Pages: 1 Online-Ressource (352 p.)
    Keywords: Medicine
    Abstract: In this Special Issue, "Pathogenesis of Pregnancy-Related Complications", 4 reviews, 13 original papers, 1 communication, and 1 case report are compiled. These papers were published by scientific teams from 24 countries, including China, Tunisia, Canada, France, Serbia, Portugal, Spain, Chile, Singapore, Australia, the USA, Mexico, the Czech Republic, Germany, Sweden, Finland, the United Kingdom, Norway, Poland, Greece, Japan, Italy, Switzerland, and Israel, which is a really great achievement
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  • 76
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    Human Biomonitoring in Health Risk Assessment : Current Practices and Recommendations for the Future (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570044 , 9783036570051
    Language: Undetermined
    Pages: 1 Online-Ressource (284 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support
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  • 77
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    Toxins : Mr Hyde or Dr Jekyll? (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569048 , 9783036569055
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolution to acquire/improve their disabling/lethal effects, they display finely tuned functional properties often associated with high affinities and selectivity. Moreover, toxins are valuable tools to unravel cellular processes due to their extreme specificity for cell surface and/or intracellular targets. Therefore, toxins are very attractive compounds because of their Janus-like character; while they mostly act as deadly poisons like monstrous Mr. Hyde, they can also be tamed into good remedies like admirable Dr. Jekyll. As such, they have been primarily investigated not only for the light they can throw on fundamental physiological processes but also for their potential therapeutic applications. This reprint, emerging from the 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet.asso.fr/international), will be of great interest for those in the scientific community who want to know more about the fascinating world of toxins
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  • 78
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    Potentially Toxic Elements Pollution in Urban and Suburban Environments (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562377 , 9783036562384
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The importance of studying pollution via potentially toxic elements (PTEs) is becoming a key challenge considering the increasing concern about the presence of PTEs in the environment and their potential impacts on ecosystem functioning and public health due to their persistence and biotoxicity. Regional geochemical research, together with geostatistical computations which are used to identify source patterns of different pollutants related to the underlying geological features and/or anthropogenic activities, is the best approach for characterizing this pollution issue. The collection of research in this Special Issue, “Potentially Toxic Element Pollution in Urban and Suburban Environments”, represents the need of the scientific community to characterize the behavior, transport, fate, and ecotoxicological state of PTEs in environmental matrices in both urban and suburban settings. All the case studies collected are of relevant significance due to their quality, both in the methodologies and the achieved results, and interest to different environmental studies, from China to South Africa to Europe. My role as Guest Editor of this Special Issue was exciting and stimulating. I would like to express my appreciation to all the authors for submitting their original contributions and to the reviewers for their essential role in the process. I would like to thank the editors of Toxics and, in particular, Selena Li for her precious and tireless support
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  • 79
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    The Pathophysiology of Preeclampsia and Eclampsia (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564111 , 9783036564104
    Language: Undetermined
    Pages: 1 Online-Ressource (334 p.)
    Keywords: Medicine
    Abstract: Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells
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  • 80
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    Current Challenges and Advances in Cataract Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562773 , 9783036562780
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed
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  • 81
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    Biosimilars in Europe (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565750 , 9783036565743
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries
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  • 82
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    Hyperbaric Medicine (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036564678 , 9783036564661
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine
    Abstract: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars
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  • 83
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    Spectroscopic, Thermodynamic and Molecular Docking Studies on Molecular Mechanisms of Drug Binding to Proteins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562261 , 9783036562254
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated
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  • 84
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    Ciguatoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564289 , 9783036564296
    Language: Undetermined
    Pages: 1 Online-Ressource (358 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
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  • 85
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    Molecular Mechanisms and Therapies of Colorectal Cancer (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565477 , 9783036565460
    Language: Undetermined
    Pages: 1 Online-Ressource (294 p.)
    Keywords: Medicine ; Oncology
    Abstract: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human development.In clinics, despite advances of diagnosis and surgical procedures, 20% of the patients with CRC present with metastasis at the time of diagnosis, caused by residual tumor cells that have spread to distant organs prior to surgery, affecting the patient survival rate. Standard systemic chemotherapy, alternative therapies that target mechanisms involved in cancer progression and metastasis, immunotherapy, and combination therapies are the major CRC-treatment strategies. In the advanced stage of CRC the transforming growth factor-beta (TGF-β) plays an oncogenic role by promoting cancer cell proliferation, cancer cell self-renewal, epithelial-to-mesenchymal transition, invasion, tumor progression, metastatic spread, and immune escape. Furthermore, high levels of TGF-β1 confers poor prognosis and is associated with early recurrence after surgery, resistance to chemo- or immunotherapy, and shorter survival. Based on the body of experimental evidence indicating that TGF-β signaling has the potential to be a good therapeutic target in CRC, several anti-TGF-β drugs have been investigated in cancer clinical trials. Here, we presented a comprehensive collection of manuscripts regarding studies on targeting the TGF-β signaling in CRC to improve patient’s prognosis and personalized treatments
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  • 86
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    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis : Diagnosis and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559698 , 9783036559704
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches
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  • 87
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    Marine Toxins from Harmful Algae and Seafood Safety (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561943 , 9783036561936
    Language: Undetermined
    Pages: 1 Online-Ressource (264 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The rapid expansion of aquaculture around the world is increasingly being impacted by toxins produced by harmful marine microalgae, which threaten the safety of seafood. In addition, ocean climate change is leading to changing patterns in the distribution of toxic dinoflagellates and diatoms which produce these toxins. New approaches are being developed to monitor for harmful species and the toxins they produce. This Special Issue covers pioneering research on harmful marine microalgae and their toxins, including the identification of species and toxins; the development of new chemical and biological techniques to identify and monitor species and toxins; the uptake of marine biotoxins in seafood and marine ecosystems; and the distribution and abundance of toxins, particularly in relation to climate change
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  • 88
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    Advanced Blood-Brain Barrier Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564173 , 9783036564166
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB)
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  • 89
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    Parasites and Wildlife (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568522 , 9783036568539
    Language: Undetermined
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint focuses on field studies aimed at unraveling the complex networks created by interactions between parasites and hosts in a given ecosystem. Since most transboundary diseases have been propagated from the wilderness to anthropized areas, societies are increasingly concerned about the relevance of wildlife as it pertains to global health. In this respect, research on parasites that may affect the biology and population equilibrium of wildlife is of major interest, especially when a One Health perspective is considered. The studies compiled in the present Special Issue fall within several areas of interest, such as epidemiology, diagnosis, emerging zoonoses, food safety, conservation issues, parasite–host interactions, and the pathology of infections caused by parasites in wild host species
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  • 90
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    Antimicrobial Therapy in Intensive Care Unit (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567693 , 9783036567686
    Language: Undetermined
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Medicine
    Abstract: This reprint is an excellent collection of articles that deal with difficult-to-treat infections in the ICU environment. Multiresistant bacteria and fungi create severe treatment problems to the physician charged with their care. We hope that this book will help everyday dilemmas and add useful information on difficult topics
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  • 91
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    Tryptophan in Nutrition and Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570778 , 9783036570761
    Language: Undetermined
    Pages: 1 Online-Ressource (324 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society
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  • 92
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    Nutrition at the Interface of Sleep and Circadian Rhythms: Implications for Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567082 , 9783036567099
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: An integral part of homeostasis includes daily rhythms in physiology, behavior, and metabolism. The circadian timing system enables organisms to adapt their biological functions to the cyclic nature of the Earth. Sleep is a fundamental physiological function, playing a crucial role in physical, mental and emotional health. Alterations of sleep quality and quantity caused by modern lifestyle and behavior as well sleep disorders are associated with an increased risk for chronic diseases. Chronic misalignment of endogenous rhythms can also lead to metabolic dysfunction. Research is starting to demonstrate the complex interrelationship between nutrition, sleep and the circadian system. For example, some foods and nutrients may impact the availability of substances that influence sleep. On the other hand, inadequate sleep is associated with an unhealthy nutrient intake and altered metabolism. Nutrients can act as drivers of circadian rhythms; they have the ability to influence circadian regulation and alter biological functions in specific tissues. A lacuna still exists in the knowledge surrounding the interplay of nutrition with sleep and the circadian system. In light of this, novel opportunities are disclosed for developing tailored nutritional recommendations with beneficial effects on sleep and circadian rhythmicity so as to improve life quality and prevent disease. The purpose of this Special Issue is therefore to collect contributions regarding this interplay and the related clinical implications
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    Chemical and Biological Threats, Hazard Potential and Countermeasures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036550374 , 9783036550381
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: In this Special Issue of Toxics entitled, “Chemical and biological threats, hazard potential and countermeasures”. In this special issue we would like to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally or on purpose endanger human health. Besides the characterization of such threats and their biological consequences we will focus on the available and novel experimental countermeasures capable to protect from and/or threat such exposures
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  • 94
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    Strategies to Enhance Drug Permeability across Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574639 , 9783036574622
    Language: Undetermined
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Overcoming biological barriers is a significant challenge in drug development, and recent advancements in drug delivery systems and technologies offer promising solutions. This Special Issue highlights the innovative approaches and techniques being used to improve drug permeability and absorption, as well as their potential impact on a wide range of therapeutic goals. These advancements being made in drug delivery and permeability offer exciting possibilities to improve patient outcomes
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  • 95
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    Nanofibrous Membrane for Biomedical Application (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577876 , 9783036577869
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine
    Abstract: Electrospinning can be used to prepare nanofibrous membranes from diverse polymers. The large surface-to-volume ratio makes them suitable for diverse fields of applications, from filters to catalysts to tissue engineering.Here, we search for the latest developments dealing with nanofiber mats for biomedicine. From wound healing to slow release, and from tissue engineering to stem cell differentiation, nanofibrous membranes can be found in a broad range of biomedical applications. For these utilizations, their chemical as well as physical properties are important, such as hydrophobicity, fiber morphology, membrane porosity, mechanical strength, etc. This Special Issue focuses on nanofibrous membranes for biomedical applications, measuring and optimizing the correlated membrane properties. It covers the full range from basic research on new materials and producing novel electrospun structure to drug release to cell growth on nanofiber mats
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  • 96
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    Novel Approaches for Overcoming Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576992 , 9783036576985
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery
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  • 97
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    Biomarkers in Neurodegenerative Diseases 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036557311 , 9783036557328
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine
    Abstract: This book follows up on the previous volume focusing on the different biomarkers for neurodegenerative diseases. It includes original research works and review articles focusing on an improved understanding of disease mechanisms. It also aims to identify aspects of early therapeutic intervention for enhanced disease management. Some critical approaches include studies involving human tissue samples, mouse disease models, and different imaging techniques. These studies present the essential information necessary to address such pathological conditions in the future
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    Food Addiction, Eating Addiction and Other Forms of Addictive-Like Eating Behavior (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574660 , 9783036574677
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine
    Abstract: There is growing evidence that among persons with disordered eating behavior, the identification of an “addictive-like eating” phenotype for some persons could be relevant and improve our ability to design better tailored interventions. This “addictive-like eating behavior” phenotype encompasses different terms or concepts, including “food addiction”, “eating addiction”, “compulsive eating behavior”, and “food craving”, but also applies to some persons with binge eating disorder, bulimia nervosa, anorexia nervosa, or binge eating symptoms. Although these terms may theoretically refer to different underlying causes or conceptualizations of addictive-like eating, all agree on the complex and multifaceted public health problem it represents and on the similarities it shares with other addictive disorders in terms of etiology, epidemiology, and treatment. Addictive-like eating behavior can deleteriously impact the patient’s outcome and may lead to poorer weight loss evolution, increased prevalence of co-occurring medical and/or psychiatric disorders, and/or lower quality of life. One of the key challenges for the present and future research is to better identify this subpopulation of patients exhibiting this addictive-like eating phenotype, and to identify the psychological/psychiatric factors and biological mechanisms underlying this increased vulnerability to addictive-like eating. Such preliminary knowledge is crucial for enabling the development of interventions targeting these vulnerability risk factors and, ultimately, improving patient outcomes
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  • 99
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    Advances in Animal Anatomy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573281 , 9783036573298
    Language: Undetermined
    Pages: 1 Online-Ressource (290 p.)
    Keywords: Medicine
    Abstract: This Special Issue covers current and relevant information about the applied anatomy of domestic animals, new companion animals and wild animals. It includes recent research and review articles on diverse topics based on the use of different diagnostic imaging techniques and more classic anatomical methods, providing a deeper insight into the healthy anatomy of diverse structures, which is crucial in high-quality medicine
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 100
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    Evaluation of Cytotoxicity and Cytoprotection. Effects of Natural Toxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570907 , 9783036570914
    Language: Undetermined
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The lifestyle associated with good quality of food is well known for its widely recognized health benefits, especially when rich in bioactive compounds. Reduced risks of some types of cancer and other diseases have been associated with the adoption of such a diet, as have increased antioxidants, inhibitors of lipid peroxidation, decrease of pro-inflammatory cytokine production, etc. The focus of this Special Issue of Toxins was to gather advances related to the cytotoxicity of natural toxins and the potential for the cytoprotection of natural compounds present in food or plants. In this context, this Special Issue of Toxins comprises eight original contributions. Special attention is given to Fridericia chica (Bignoniaceae) leaves grown in Colombia, extract from Polygonum cuspidatum, Artemisia annua and coffee extracts against mycotoxins´ effects. Studies of mycotoxins in different animal and human cell lines are also presented for zearalenone, beauvericin, α-zearalenol and β-zearalenol, among others
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
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