ISSN:
0378-8741
Language:
English
Titel der Quelle:
Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
Publ. der Quelle:
Shannon : Elsevier Science Ireland
Angaben zur Quelle:
Vol. 183 (2016), p. 187-192
DDC:
610
Abstract:
Aconitum carmichaelii Debeaux is a well-known Chinese herb that has been used to treat liver diseases for many years in China. We investigated the effects of aqueous extract from Aconitum carmichaelii Debeaux (AEACD) on acute liver failure and identified the possible mechanisms of these effects. Specific pathogen-free (SPF) male Wistar rats were used to establish acute liver failure model by intraperitoneal injection of D-galactosamine (D-GalN) and treated with Stronger Neo-Minophagen C (SNMC) and AEACD by gavage. Then, the serum biochemical parameters, the pathological scores in the liver tissue, the mRNA expressions of toll- like receptor 4 (TLR4), nuclear factor kappa B (NF-κB), high mobility group box 1 (HMGB1) and caspase-3, the proliferating cell nuclear antigen (PCNA) positive rates were analyzed. The liver function was improved, the pathological scores were decreased, the expressions the TLR4, NF-κB, HMGB1, and caspase-3 were inhibited, and the PCNA positive rates were increased by both SNMC and AEACD, but AEACD induced greater effects. AEACD protected liver function by inhibiting inflammatory reaction, apoptosis and promoting liver tissue regeneration in the acute liver failure rats induced by D-galactosamine.
Note:
Copyright: Copyright © 2016. Published by Elsevier Ireland Ltd.
DOI:
10.1016/j.jep.2016.01.020
URL:
http://www.sciencedirect.com/science/article/pii/S037887411630023X
URL:
http://www.ncbi.nlm.nih.gov/pubmed/26806574
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