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  • 1
    Article
    Article
    Associated volumes
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 172 (2015), p. 410-420
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 172 (2015), p. 410-420
    DDC: 610
    Abstract: Polytrichum commune L.ex Hedw (PCLH), a moss of Bryopsida, has been used as a traditional Chinese medicine and shown to possess anticancer activities. Previous studies have indicated its anti-leukemia effect but the potential mechanisms have not been fully explained. The present study aimed to further investigate the efficacy of PCLH ethyl acetate fraction (PC-EEF) and the associated mechanisms in human leukemia cells. Phytochemical analysis of PC-EEF was performed by spectrophotometry and HPLC. MTT analysis and trypan blue exclusion assay were adopted to examine its cytotoxicity on a panel of leukemia cells (K562, U937, HL-60 and K562/DOX cells) and non-cancerous cells (human PBMCs). Anti-proliferative effect was monitored by colony formation assay and EdU incorporation assay. Ultrastructural alterations on K562 cell membrane surface were observed by scanning electron microscopy. Changes on plasma membrane integrity, cell membrane potential, mitochondrial membrane potential and apoptosis were analyzed by flow cytometry. Fluorescence microscope was performed to assess [Ca(2+)]i level, mitochondrial injury and cytochrome c release. Apoptosis-associated protein expression was analyzed by western blot. The role of Ca(2+) in PC-EEF-induced cell death was investigated by Ca(2+) chelating reagent BAPTA-AM. PC-EEF possessed relatively high flavonoid content (about 88.84 ± 0.89%) and showed significant cytotoxicity to human leukemia cells. PC-EEF could cause obvious cell morphological deformation, membrane integrity loss and membrane depolarization. Meanwhile, PC-EEF treatment could dramatically potentiate perturbations in cellular Ca(2+) homeostasis. Subsequently, mitochondrial membrane potential (MMP) collapse, cytochrome c release and Bcl-2/Bax down-regulation were all observed. Consistent with these results, PC-EEF treatment resulted in significant activation of caspase 3, poly (ADP-ribose) polymerase (PARP) degradation and apoptosis. Moreover, PC-EEF-caused cytotoxicity, membrane damage, mitochondrial injury and apoptosis were remarkably reversed by BAPTA-AM. PC-EEF damaged the membrane system and triggered Ca(2+)-dependent mitochondrial apoptosis, which may provide some new insights into its efficacy against human leukemia cells.
    Note: Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
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  • 2
    Article
    Article
    Associated volumes
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 143, No. 1 (2012), p. 49-57
    ISSN: 0378-8741
    Language: Undetermined
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 143, No. 1 (2012), p. 49-57
    DDC: 610
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  • 3
    Article
    Article
    Associated volumes
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 144, No. 2 (2012), p. 322-328
    ISSN: 0378-8741
    Language: Undetermined
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 144, No. 2 (2012), p. 322-328
    DDC: 610
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  • 4
    Article
    Article
    Associated volumes
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 148, No. 3 (2013), p. 926-933
    ISSN: 0378-8741
    Language: Undetermined
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 148, No. 3 (2013), p. 926-933
    DDC: 610
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  • 5
    Book
    Book
    London [u.a.] : Routledge
    ISBN: 9781138024250 , 9781315775890
    Language: English
    Pages: 247 S. , graph. Darst.
    Series Statement: Asian Studies Association of Australia women in Asia series 7
    DDC: 306.810951
    Keywords: Interracial marriage ; Marriage ; Divorce ; Eheschließung ; Ehe ; Interethnische Ehe ; Ehescheidung ; China ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung ; China ; Eheschließung ; Ehe ; Interethnische Ehe ; Ehescheidung
    Abstract: "As China globalises the number of marriages between Chinese people and foreigners is increasing. These Chinese-foreign marriages have profound implications for China's cultural identity. This book, based on extensive original research, outlines the different types of Chinese-foreign marriage, and divorce, and the changing scale and changing patterns of such marriages, and divorces, and examines how such marriages and divorces are portrayed in different kinds of media. It shows how those types of Chinese-foreign marriage where Chinese patriotism and Chinese values are preserved are depicted favourably, whereas other kinds of Chinese-foreign marriage, especially those where Chinese women marry foreign nationals, are disapproved of, male foreign nationals being seen as having a propensity to infidelity, deception, violence and taking advantage of Chinese women. The book contrasts the portrayal of Chinese-foreign marriage with the reality, and with the depiction of Chinese-Chinese marriage where many of the same problems apply. Overall, the book sheds much light on changing social processes and on current imaginings of China's place in the world"--
    Abstract: "As China globalises the number of marriages between Chinese people and foreigners is increasing. These Chinese-foreign marriages have profound implications for China's cultural identity. This book, based on extensive original research, outlines the different types of Chinese-foreign marriage, and divorce, and the changing scale and changing patterns of such marriages, and divorces, and examines how such marriages and divorces are portrayed in different kinds of media. It shows how those types of Chinese-foreign marriage where Chinese patriotism and Chinese values are preserved are depicted favourably, whereas other kinds of Chinese-foreign marriage, especially those where Chinese women marry foreign nationals, are disapproved of, male foreign nationals being seen as having a propensity to infidelity, deception, violence and taking advantage of Chinese women. The book contrasts the portrayal of Chinese-foreign marriage with the reality, and with the depiction of Chinese-Chinese marriage where many of the same problems apply. Overall, the book sheds much light on changing social processes and on current imaginings of China's place in the world"--
    Note: Includes bibliographical references and index
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  • 6
    ISBN: 9781978822863
    Language: English
    Pages: 1 Online-Ressource (254 p.) , 3 color illustrations, 4 tables
    Series Statement: Politics of Marriage and Gender: Global Issues in Local Contexts
    DDC: 306.81
    Abstract: Arranged Marriage: The Politics of Tradition, Resistance, and Change shows how arranged marriage practices have been undergoing transformation as a result of global and other processes such as the revolution of digital technology, democratization of transnational mobility, or shifting significance of patriarchal power structures. The ethnographically informed chapters not only highlight how the gendered and intergenerational politics of agency, autonomy, choice, consent, and intimacy work in the contexts of partner choice and management of marriage, but also point out that arranged marriages are increasingly varied and they can be reshaped, reinvented, and reinterpreted flexibly in response to individual, family, religious, class, ethnic and other desires, needs, and constraints. The authors convincingly demonstrate that a nuanced investigation of the reasons, complex dynamics, and consequences of arranged marriages offers a refreshing analytical lens that can significantly contribute to a deeper understanding of other phenomena such as globalization, modernization, international migration as well as patriarchal value regimes, intergenerational power imbalances, and gendered subordination and vulnerability of women.
    URL: Cover
    URL: Volltext  (URL des Erstveröffentlichers)
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