ISBN:
9781468483321
Language:
English
Pages:
Online-Ressource
,
online resource
Edition:
Springer eBook Collection. Humanities, Social Sciences and Law
DDC:
50
Keywords:
Science (General)
Description / Table of Contents:
1. Measuring Drug ActivityMeasuring the Effects of Drugs: ‘Responses’ -- Assessing Biological Activity -- Application of Bioassay Methods to the Comparison of Drugs -- Types of Drug Action -- 2. Physicochemical Problems -- Rates of Reaction and Positions of Equilibrium -- Solubility -- Volume of Dilution -- Rate of Removal -- Rate of Absorption -- Partition Coefficients and Crossing Membranes -- Relations between Reaction Rates and Equilibrium Constants -- 3. The Size and Shape of Molecules -- Size: Molal Volumes and Apparent Molal Volumes -- Shape -- Isomerism -- Optical Rotation -- Stereochemical Purity and Biological Activity -- Description of the Arrangements of Groups about an Asymmetric Carbon Atom -- Preferred Conformations -- 4. Chemical Processes where Size and Shape are Important -- Adsorption -- Adsorption of Two Species -- Enzyme and Substrate -- The Need for Other Models -- Agonists and Receptors -- Rate Theory -- Desensitisation of Receptors -- Forces between Drug and Receptor -- 5. The Prediction of Drug Activity -- Nonspecific Activity -- Homologous Series -- Biological Activity and Chemical Properties: the Ideas of Hansch -- Is Affinity Predictable? -- Conclusion -- Appendix: Line-fitting by the method of least-squares -- Answers to Examples.
DOI:
10.1007/978-1-4684-8332-1
URL:
Volltext
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