ISBN:
9789400958869
Language:
English
Pages:
Online-Ressource
,
online resource
Edition:
Springer eBook Collection. Humanities, Social Sciences and Law
Parallel Title:
Erscheint auch als
Parallel Title:
Erscheint auch als
Parallel Title:
Erscheint auch als
Keywords:
Science (General)
;
Social sciences.
;
Humanities.
Abstract:
1. Multiple Forms of Enzymes and the Emergence of the Isoenzyme Concept -- 2. Origins and Structures of Multiple Forms of Enzymes -- Origins of isoenzymes -- Structural differences between isoenzymes and their investigation -- Non-isoenzymic multiple forms of enzymes -- 3. Differences in Properties between Multiple Forms of Enzymes -- Catalytic differences between multiple forms of enzymes -- Physicochemical differences between multiple forms of enzymes -- Immunochemical differences between multiple forms of enzymes -- Properties of multiple forms of enzymes: general considerations -- 4. Distribution and Biological Functions of Multiple Forms of Enzymes -- Distribution of enzymes determined by multiple gene loci -- Physiological function of multiple forms of enzymes -- 5. Multiple Forms of Enzymes in Phylogeny and Genetics -- Gene duplication and the evolution of multiple loci -- Genetics of isoenzymes -- 6. Multiple Forms of Enzymes in Ontogeny -- Changes during normal development -- Changes associated with abnormal development -- 7. Multiple Forms of Enzymes in Diagnostic Enzymology -- Lactate dehydrogenase isoenzymes -- Creatine kinase isoenzymes -- Multiple forms of alkaline phosphatase -- Acid phosphatase isoenzymes -- Other isoenzymes -- References.
Abstract:
The increased interest in multiple forms of enzymes that began with the application of new methods of fractionation to preparations of enzymes and other proteins some 25 years ago led quickly to an appreciation that the existence of enzymes in multiple forms, or isoenzymes, is a general phenomenon. The results of pioneering studies and those which followed in the early years of isoenzyme research consisted, not surprisingly, mainly of descriptions of the existence and characteristics of hetero geneity in various enzyme systems. Summaries of these results were provided in books such as J . H. Wilkinson's I soenzymes, the first edition of which appeared in 1965. Some clearer ideas of the nature of the phenomena had become apparent by the time that the second edition of Isoenzymes was called for in 1970, and a limited use of the word isoenzymes itself, to describe only certain of the various categories of enzyme multiplicity then recognized, was already being proposed. Nevertheless, a largely enzyme-by-enzyme oTganization of the contents of the book was still appropriate. Considerable advances, both experimental and conceptual, were made in isoenzyme research in the 1970s, and in 1977 Professor Wilkinson suggested to the present author that these should be taken into account in a joint revision of Isoenzymes. Professor Wilkinson's untimely death put. an end to this project and the present book is therefore the work of a single author.
Description / Table of Contents:
1. Multiple Forms of Enzymes and the Emergence of the Isoenzyme Concept2. Origins and Structures of Multiple Forms of Enzymes -- Origins of isoenzymes -- Structural differences between isoenzymes and their investigation -- Non-isoenzymic multiple forms of enzymes -- 3. Differences in Properties between Multiple Forms of Enzymes -- Catalytic differences between multiple forms of enzymes -- Physicochemical differences between multiple forms of enzymes -- Immunochemical differences between multiple forms of enzymes -- Properties of multiple forms of enzymes: general considerations -- 4. Distribution and Biological Functions of Multiple Forms of Enzymes -- Distribution of enzymes determined by multiple gene loci -- Physiological function of multiple forms of enzymes -- 5. Multiple Forms of Enzymes in Phylogeny and Genetics -- Gene duplication and the evolution of multiple loci -- Genetics of isoenzymes -- 6. Multiple Forms of Enzymes in Ontogeny -- Changes during normal development -- Changes associated with abnormal development -- 7. Multiple Forms of Enzymes in Diagnostic Enzymology -- Lactate dehydrogenase isoenzymes -- Creatine kinase isoenzymes -- Multiple forms of alkaline phosphatase -- Acid phosphatase isoenzymes -- Other isoenzymes -- References.
DOI:
10.1007/978-94-009-5886-9
URL:
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