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  • MPI Ethno. Forsch.  (53)
  • English  (53)
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (53)
  • Proteins  (53)
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  • MPI Ethno. Forsch.  (53)
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  • 1
    Online Resource
    Online Resource
    Homology Molecular Modeling : Perspectives and Applications (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839628061 , 9781839628054 , 9781839628115
    Language: English
    Pages: 1 Online-Ressource (146 p.)
    Keywords: Proteins
    Abstract: Homology modeling is an extremely useful and versatile technique that is gaining more and more space and demand in research in computational and theoretical biology. This book, “Homology Molecular Modeling - Perspectives and Applications”, brings together unpublished chapters on this technique. In this book, 7 chapters are intimately related to the theme of molecular modeling, carefully selected and edited for academic and scientific readers. It is an indispensable read for anyone interested in the areas of bioinformatics and computational biology. Divided into 4 sections, the reader will have a didactic and comprehensive view of the theme, with updated and relevant concepts on the subject. This book was organized from researchers to researchers with the aim of spreading the fascinating area of molecular modeling by homology
    Note: English
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  • 2
    Online Resource
    Online Resource
    Oxidoreductase (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838809010 , 9781838809003 , 9781838809027
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Series Statement: Biochemistry 19
    Keywords: Proteins
    Abstract: Oxidoreductase enzymes are a group of enzymes that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. Oxidoreductase enzymes utilize NADP+ or NAD+ as cofactors. Oxidoreductase enzymes include the following: oxidase, dehydrogenase, peroxidase, hydroxylase, oxygenase, and reductase. Most oxidoreductase enzymes are dehydrogenases. However, reductases are also common. The accepted nomenclature for dehydrogenases is “donor dehydrogenase”, where the donor is the oxidized substrate. Metabolic abnormalities disorders resulting from a deficiency (quantitative and qualitative) or from over-activity of oxidoreductase, which may contribute to the decreased normal performance of life, are becoming common. This book covers the potential applications of oxidoreductases on the growth of oxidoreductase-based diagnostic tests and better biosensors in the design of inventive systems for crucial co-enzyme generations and in the synthesis of polymers and organic substrates. The book describes the role of oxidoreductase as essential in medical drug formation. It can be employed to produce a huge amount of compounds that act as medical mediators like Cephalosporin (beta lactam antibiotic). Furthermore, the idea of how to use different enzymes as targets for medical treatment in different types of cancers is also described in this book
    Note: English
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  • 3
    Online Resource
    Online Resource
    Methods in Molecular Medicine (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839627279 , 9781839627262 , 9781839627286
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Proteins
    Abstract: Treatment risk and response to therapy prediction can be forecasted through early diagnosis, which improves prognosis reliability and effectiveness of therapies. This book covers contemporary advances in molecular markers, disease-causing variants, retroelements, and the basis of distinct diseases
    Note: English
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  • 4
    Online Resource
    Online Resource
    Update on Mesenchymal and Induced Pluripotent Stem Cells (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789238082 , 9781789238075 , 9781838805265
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Proteins
    Abstract: This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders
    Note: English
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  • 5
    Online Resource
    Online Resource
    Chemistry and Biological Activity of Steroids (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789855166 , 9781789855159 , 9781789856088
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Proteins
    Abstract: The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed
    Note: English
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  • 6
    Online Resource
    Online Resource
    Biophysical Chemistry : Advance Applications (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789840483 , 9781789840476 , 9781838801380
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Series Statement: Physiology 7
    Keywords: Proteins
    Abstract: Biophysical chemistry is one of the most interesting interdisciplinary research fields. Some of its different subjects have been intensively studied for decades. Now the field attracts not only scientists from chemistry, physics, and biology backgrounds but also those from medicine, pharmacy, and other sciences. We aimed to start this version of the book Biophysical Chemistry from advanced principles, as we include some of the most advanced subject matter, such as advanced topics in catalysis applications (first section) and therapeutic applications (second section). This led us to limit our selection to only chapters with high standards, therefore there are only six chapters, divided into two sections. We have assumed that the interested readers are familiar with the fundamentals of some advanced topics in mathematics such as integration, differentiation, and calculus and have some knowledge of organic and physical chemistry, biology, and pharmacy. We hope that the book will be valuable to graduate and postdoctoral students with the requisite background, and by some advanced researchers active in chemistry, biology, biochemistry, medicine, pharmacy, and other sciences
    Note: English
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  • 7
    Online Resource
    Online Resource
    Glutathione System and Oxidative Stress in Health and Disease (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838801267 , 9781838801250 , 9781839680182
    Language: English
    Pages: 1 Online-Ressource (138 p.)
    Series Statement: Biochemistry 17
    Keywords: Proteins
    Abstract: The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system
    Note: English
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  • 8
    Online Resource
    Online Resource
    Innovations in Cell Research and Therapy (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789844573 , 9781789844566 , 9781838800208
    Language: English
    Pages: 1 Online-Ressource (162 p.)
    Keywords: Proteins
    Abstract: All living things are comprised of cells. A cell is the building block of complex organisms. All cells contain genetic material. Some cells contain subunits known as organelles that perform specific functions. Protein processing, energy generation, and macromolecular biosynthesis are some of the functions of organelles. Recently, advances in cell biology have elucidated new insights in cellular development and the unique functions of different types of cells. The era of biotechnology is rooted in biologics, and cell biology has delivered novel therapeutic candidates. Personalized medicine has its underpinnings in cell biology. Innovations in Cell Research and Therapy focuses on recent key advances that are transforming health and medical sciences. Understanding fundamental cellular processes, including cellular differentiation, the many applications of stem cells, natural and synthetic approaches for inducing apoptosis, and new insights into organelle biology and macromolecular processing are representative examples of the topics that are addressed in the chapters found in this book
    Note: English
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  • 9
    Online Resource
    Online Resource
    Lipid Peroxidation Research (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839685484 , 9781839685477 , 9781839685491
    Language: English
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Proteins
    Abstract: Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases
    Note: English
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  • 10
    Online Resource
    Online Resource
    Free Radical Medicine and Biology (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789851441 , 9781789851434 , 9781839625954
    Language: English
    Pages: 1 Online-Ressource (130 p.)
    Series Statement: Physiology 10
    Keywords: Proteins
    Abstract: Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems
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  • 11
    Online Resource
    Online Resource
    Advances in Lipid Metabolism (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789844597 , 9781789844580 , 9781789851373
    Language: English
    Pages: 1 Online-Ressource (98 p.)
    Keywords: Proteins
    Abstract: This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of lipid metabolism. It includes scholarly contributions from experts in the field that cover such topics as roles of lipids in cancer, analytical tools for lipid assessment in biological assays, plant lipid metabolism, the effect of nanoparticles on lipid peroxidation in plants, and fatty acid compositions in fermented fish products. This book provides a thorough overview of the latest research efforts by international authors on lipid metabolism, and opens new possible research paths for further novel developments
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  • 12
    Online Resource
    Online Resource
    Proteoforms : Concept and Applications in Medical Sciences (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838800345 , 9781838800338 , 9781839628320
    Language: English
    Pages: 1 Online-Ressource (90 p.)
    Keywords: Proteins
    Abstract: A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia
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  • 13
    Online Resource
    Online Resource
    Telomerase and non-Telomerase Mechanisms of Telomere Maintenance (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845754 , 9781789845747 , 9781838802813
    Language: English
    Pages: 1 Online-Ressource (130 p.)
    Keywords: Proteins
    Abstract: This book, Telomerase and non-Telomerase Mechanisms of Telomere Maintenance, is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of biochemistry, genetics, and molecular biology. The book comprises single chapters authored by various researchers and edited by an expert active in the molecular biology research area. All chapters are individually complete but united under a common research topic. This publication aims to provide a thorough overview of the latest research efforts by international authors on biochemistry, genetics,and molecular biology, and open new possible research paths for further novel developments. A note from the publisher: It is with great sadness and regret that we inform the contributing authors and readers of this book that the Editor, Dr Tammy A. Morrish, passed away during the publishing process of the book and before having a chance to see its publication. The book Telomerase and non-Telomerase Mechanisms of Telomere Maintenance was her first edited volume with us. Fruitful collaboration continued until her final days. We would like to acknowledge Dr Morrish's contribution to scientific publishing, which she made during years of dedicated work, and express our gratitude for her pleasant cooperation with us
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  • 14
    Online Resource
    Online Resource
    Understanding the Molecular Crosstalk in Biological Processes (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789848939 , 9781789848922 , 9781838819651
    Language: English
    Pages: 1 Online-Ressource (90 p.)
    Keywords: Proteins
    Abstract: It is essential to address the aspects related to the crosstalk approach in understanding complex biological processes in different organisms, including plants, microorganisms, animals, and humans. This will definitely provide the information required to achieve the biological advancements. Therefore, this book highlights the advances made in the research field covering crosstalk in different biological processes. Current research trends, future research directions, and challenges are also addressed. This book will provoke the interest of various readers, researchers, and scientists who will find this information useful for the advancement of their research on biological processes in living organisms
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  • 15
    Online Resource
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    Toll-like Receptors (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789853919 , 9781789845235 , 9781789853926
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Keywords: Proteins
    Abstract: Toll-like receptors (TLRs) are pattern recognition receptors that allow innate immunity to protect our body against invading pathogens. They are alsoregulators of adaptive immunity. The human TLR was discovered quite recently, but its functional significance is known worldwide and today TLR agonists have been approved for use in humans. This book provides an overview of TLRs and their role in parasitic infections and neurodegenerative diseases. It is hoped that it will encourage readers to seek out the latest developments in TLRs
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  • 16
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    Ubiquitin : Proteasome Pathway (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838808419 , 9781838804329 , 9781838808426
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Series Statement: Biochemistry 18
    Keywords: Proteins
    Abstract: The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases
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  • 17
    Online Resource
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    Cell Growth (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789845570 , 9781789238068 , 9781789853117
    Language: English
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Proteins
    Abstract: This book on cell growth is the ideal resource for a scientist who wishes to learn more about cell growth topics. It provides information on plant growth hormones, kinetic studies on cell growth, growth of fungal cells and production, cell growth measurement, ion homeostasis response to nutrient deficiency stress in plants, intracellular lipid homeostasis in eukaryotes, and cell-based assays in cancer research. Each topic begins with a summary of the essential facts. Chapters were carefully edited to maintain consistent use of terminology and approach of covering topics in a uniform, systematic format
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  • 18
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    Immunohistochemistry : The Ageless Biotechnology (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838808211 , 9781838808204 , 9781838808228
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Proteins
    Abstract: Immunohistochemistry - The Ageless Biotechnology is a book that is ideal for undergraduate and graduate biomedical researchers, and medical and dental health professionals. It is a detailed text, which emphasizes the laboratory and clinical implications of immunohistochemistry. The text covers the advances of immunohistochemistry from its humble origins in the 1930s up to the new decade of 2020. The book also offers a review of the immunohistochemistry detection systems with emphasis on their principles, history, and their advantages. It also stipulates the limitations and delineates the factors that need to be considered for choosing an appropriate detection system for IHC applications. The book describes current laboratory techniques and new applications for the technology. As the reader will observe, the book provides new and useful information concerning the rapidly advancing field of immunohistochemistry
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  • 19
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    Extracellular Vesicles and Their Importance in Human Health (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789239447 , 9781789239430 , 9781789845839
    Language: English
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Proteins
    Abstract: Extracellular vesicle is a wide term that involves many different types of vesicles. Almost all the cell types studied secrete vesicles to the extracellular environment related to cell - cell communication. Extracellular vesicles have been found in different biological fluids, such as blood, milk, saliva, tears, urine, and cerebrospinal fluid. These vesicles transport different molecules, including mRNA, proteins, and lipids, some of them cell type specific that make them ideal biomarkers in both health and disease conditions. However, their contribution to different conditions is not well understood. The aim of this book is to provide an overview of the extracellular vesicles in the human body, how they are internalized, and their participation in several diseases
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  • 20
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    Programmed Cell Death (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789847499 , 9781789847482 , 9781839684708
    Language: English
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Proteins
    Abstract: This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches
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  • 21
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    Liposomes : Advances and Perspectives (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789844955 , 9781789844948 , 9781838812324
    Language: English
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Proteins
    Abstract: Liposomes have received increased attention in recent years. Nevertheless, liposomes, due to their various forms and applications, require further investigation. These structures can deliver both hydrophilic and hydrophobic drugs. The preparation of liposomes results in different properties for these systems. In addition, there are many factors and difficulties that affect the development of liposome drug delivery structures.The purpose of this book is to concentrate on recent developments in liposomes. The articles collected in this book are contributions by invited researchers with long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with a general background in many different biological sciences. This volume offers up-to-date, expert reviews of the fast-moving field of liposomes and is divided in two major sections: 1. Introduction; 2. Liposomes general properties
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  • 22
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    Peptide Synthesis (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781839682582 , 9781839682575 , 9781839682599
    Language: English
    Pages: 1 Online-Ressource (118 p.)
    Keywords: Proteins
    Abstract: Peptide synthesis includes an array of techniques and procedures that enable the preparation of materials ranging from small peptides to large proteins. Many synthetic peptides have commercial and pharmaceutical applications, however, the synthesis of these peptides is a difficult task. This book addresses the common problems relating to the synthesis and applications of synthetic peptides. It discusses novel methods for the efficient synthesis of long chain and difficult peptide sequences and presents detailed analysis of various aspects of solid phase peptide synthesis. It also includes a section on antimicrobial peptides
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  • 23
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    Molecular Medicine (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781839627606 , 9781839627590 , 9781839627613
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Proteins
    Abstract: Molecular medicine is an applied science focused on human genes/transcripts, proteins, metabolites, and metabolic networks that describes molecular and cellular processes of health and disease onset and progression. Molecular medicine-based integrative identification and characterization of biomarker targets and their clinical translations is essential to explain/decipher the mechanism(s) underlying physiological pathways and pathological conditions, and acquire cell-targeted early interventional and therapeutic strategies in the context of precision medicine and public health. Principally, Molecular Medicine provides an overview of the latest headlines/developments of systems and molecular medicine, highlighting the emerging high-throughput technologies, promising potential applications, and progress in biomedical research and development strategies
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  • 24
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    Non-Proteinogenic Amino Acids (2018)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9781789847291 , 9781789847284 , 9781838815974
    Language: English
    Pages: 1 Online-Ressource (72 p.)
    Keywords: Proteins
    Abstract: The first description of homocysteine (Hcy), a non-proteinogenic amino acid, was introduced in a case study more than 70 years ago. In recent years, numerous studies have shown a positive correlation between serum levels and various diseases, especially vascular pathology. Vitamins B6, B12, and folic acid play a major role in controlling homocysteine levels. In this book are presented both methods for the determination of homocysteine and its involvement in human pathology. Homocysteine levels can be taken as an early indicator for the detection of cardiovascular diseases because Hcy levels increase after a myocardial infarction or stroke
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  • 25
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    Pluripotent Stem Cells : From the Bench to the Clinic (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535124726 , 9789535124719 , 9789535172871
    Language: English
    Pages: 1 Online-Ressource (532 p.)
    Keywords: Proteins
    Abstract: Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors
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  • 26
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    Progress in Stem Cell Transplantation (2015)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535122272 , 9789535172734
    Language: English
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Proteins
    Abstract: This book documents the increased amount of stem cell-related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies discussed in basic and clinical chapters from authors around the world involved in stem cell studies and research. It thereby complements and extends the basic coverage of stem cells, such as mesenchymal stem cells, effect of stem cells on aging, cover hematopoietic stem cells, storage and cryopreservation, issues related to clinical applications such as haploidentical transplants and use of stem cells for the treatment of Huntingtons disease. Clearly, the treatment of various malignant and nonmalignant diseases depends heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments
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    MPI Ethno. Forsch.
  • 27
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    Pluripotent Stem Cell Biology : Advances in Mechanisms, Methods and Models (2014)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535115908 , 9789535172130
    Language: English
    Pages: 1 Online-Ressource (242 p.)
    Keywords: Proteins
    Abstract: Pluripotent stem cells have the potential to revolutionize treatment options for a range of diseases and conditions. This book presents recent advances in our understanding of the biological mechanisms of stem cell self-renewal, reprograming and regeneration. Also covered are novel methodological advances in the culture, purification and use of stem cells, as well as the ethical and moral dilemmas of embryo donation and adoption. These advances will shape the utilization of stem cells for future basic and applied applications
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  • 28
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    Adult Stem Cell Niches (2014)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535117186 , 9789535172208
    Language: English
    Pages: 1 Online-Ressource (330 p.)
    Keywords: Proteins
    Abstract: Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches
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  • 29
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    Oxidative Stress and Chronic Degenerative Diseases : A Role for Antioxidants (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111238 , 9789535153740
    Language: English
    Pages: 1 Online-Ressource (514 p.)
    Keywords: Proteins
    Abstract: This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases
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  • 30
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    Innovations in Stem Cell Transplantation (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109808 , 9789535170877
    Language: English
    Pages: 1 Online-Ressource (380 p.)
    Keywords: Proteins
    Abstract: This book documents the increased number of stem cell related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies containing basic and clinical chapters from the respected authors involved in stem cell studies and research around the world. It thereby complements and extends the basic coverage of stem cells such as immunogenetics, neuron replacement therapy, cover hematopoietic stem cells, issues related to clinical problems, advanced HLA typing, alternative donor sources as well as gene therapy that employs novel methods in this field. Clearly, the treatment of various malignancies and biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments
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  • 31
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    Pluripotent Stem Cells (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111924 , 9789535171782
    Language: English
    Pages: 1 Online-Ressource (640 p.)
    Keywords: Proteins
    Abstract: Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same
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  • 32
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    Neural Stem Cells : New Perspectives (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110699 , 9789535171331
    Language: English
    Pages: 1 Online-Ressource (430 p.)
    Keywords: Proteins
    Abstract: Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans. On the other side, many problems arise when stem cells encounter the mature brain parenchyma, still hampering the development of efficacious therapeutic approaches with endogenous or exogenously-delivered neural stem cells. This book tries to make the point on these extremely promising, yet unresolved, issues
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  • 33
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    Future Aspects of Tumor Suppressor Gene (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110637 , 9789535171249
    Language: English
    Pages: 1 Online-Ressource (232 p.)
    Keywords: Proteins
    Abstract: Tumor suppressor genes (TSGs) and their signaling networks are fast growing areas in current biomedical science. These groups of genes, which are not limited to tumor suppression, play critical roles in many cellular activities. This book, "Future Aspects of Tumor Suppressor Genes", contains some fascinating fields, from basic to translational researches, in recent TSG studies. For example, several TSG signaling pathways are addressed in this book, and both mouse and Drosophila models used for the exploration of these genes are described based on the experimental evidence. A detailed review for current knowledge of microRNA studies in the regulation of tumor growth is introduced. Additionally, how natural compounds interfere with the progression of cancer development via TSG pathways is systemically summarized. Recent progresses in cell reprogramming and stemness transition processes regulated by TSG pathways are also included in this book
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  • 34
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    Stem Cell Biology in Normal Life and Diseases (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111078 , 9789535171416
    Language: English
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Proteins
    Abstract: Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia)
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  • 35
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    Embryology : Updates and Highlights on Classic Topics (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535104650 , 9789535169505
    Language: English
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Proteins
    Abstract: Embryology is a branch of science concerned with the morphological aspects of organismal development. The genomic and molecular revolution of the second half of the 20th century, together with the classic descriptive aspects of this science have allowed greater integration in our understanding of many developmental events. Through such integration, modern embryology seeks to provide practical knowledge that can be applied to assisted reproduction, stem cell therapy, birth defects, fetal surgery and other fields. This book focuses on human embryology and aims to provide an up-to-date source of information on a variety of selected topics. The book consists of nine chapters organized into three sections, namely: 1) gametes and infertility, 2) implantation, placentation and early development, and 3) perspectives in embryology. The contents of this book should be of interest to biology and medical students, clinical embryologists, laboratory researchers, obstetricians and urologists, developmental biologists, molecular geneticists and anyone who wishes to know more about recent advances in human development
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  • 36
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    Enzyme Inhibition and Bioapplications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535105855 , 9789535152941
    Language: English
    Pages: 1 Online-Ressource (332 p.)
    Keywords: Proteins
    Abstract: Enzyme Inhibition and Bioapplications is a concise book on applied methods of enzymes used in drug testing. The present volume will serve the purpose of applied drug evaluation methods in research projects, as well as relatively experienced enzyme scientists who might wish to develop their experiments further. Chapters are arranged in the order of basic concepts of enzyme inhibition and physiological basis of cytochromes followed by new concepts of applied drug therapy; reliability analysis; and new enzyme applications from mechanistic point of view
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  • 37
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    Advances in Protein Kinases (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106333 , 9789535153016
    Language: English
    Pages: 1 Online-Ressource (386 p.)
    Keywords: Proteins
    Abstract: Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development
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  • 38
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    Protein Purification (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533078311 , 9789535151821
    Language: English
    Pages: 1 Online-Ressource (234 p.)
    Keywords: Proteins
    Abstract: The current volume entitled Protein Purification is designed to facilitate rapid access to valuable information about various methodologies. It aims as well to provide an overview of state-of-art techniques for the purification, analysis and quantification of proteins in complex samples using different enrichment strategies
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  • 39
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    New Advances in Stem Cell Transplantation (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100133 , 9789535167983
    Language: English
    Pages: 1 Online-Ressource (596 p.)
    Keywords: Proteins
    Abstract: This book documents the increased number of stem cell-related research, clinical applications, and views for the future. The book covers a wide range of issues in cell-based therapy and regenerative medicine, and includes clinical and preclinical chapters from the respected authors involved with stem cell studies and research from around the world. It complements and extends the basics of stem cell physiology, hematopoietic stem cells, issues related to clinical problems, tissue typing, cryopreservation, dendritic cells, mesenchymal cells, neuroscience, endovascular cells and other tissues. In addition, tissue engineering that employs novel methods with stem cells is explored. Clearly, the continued use of biomedical engineering will depend heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments
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  • 40
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    Neural Stem Cells and Therapy (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533079585 , 9789535167730
    Language: English
    Pages: 1 Online-Ressource (454 p.)
    Keywords: Proteins
    Abstract: This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy
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  • 41
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    Applications of Immunocytochemistry (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535102298 , 9789535152354
    Language: English
    Pages: 1 Online-Ressource (332 p.)
    Keywords: Proteins
    Abstract: Immunocytochemistry is classically defined as a procedure to detect antigens in cellular contexts using antibodies. However, over the years many aspects of this procedure have evolved within a plethora of experimental setups. There are different ways to prepare a given specimen, different kinds of antibodies to apply, different techniques for imaging, and different methods of analyzing the data. In this book, various ways of performing each individual step of immunocytochemistry in different cellular contexts are exemplified and discussed. Applications of Immunocytochemistry offers technical and background information on different steps of immunocytochemistry and presents the application of this technique and its adaptations in cell lines, neural tissue, pancreatic tissue, sputum cells, sperm cells, preimplantation embryo, arabidopsis, fish gonads, and Leishmania
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  • 42
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    Proteomics : Human Diseases and Protein Functions (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533078328 , 9789535151838
    Language: English
    Pages: 1 Online-Ressource (452 p.)
    Keywords: Proteins
    Abstract: Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research
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  • 43
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    Biomedicine (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535103523 , 9789535169208
    Language: English
    Pages: 1 Online-Ressource (214 p.)
    Keywords: Proteins
    Abstract: Comprehensive and systematic scientific researches in cell biology and molecular biology have promoted the evolution of traditional medicine. Scientists are now able to interpret a few perplexed medical difficulties with the emphasis on molecular levels. This book focuses on frontier progress in modern biomedical science dealing with regenerative medicine, gene medicine, nanobiomedicine, and medical devices. Each chapter is intently chosen and written by professional experts in the field of biomedical science. Biomedicine is a valuable guide for the readers to become aware of current advancement in rapidly moving field of biomedicine
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  • 44
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    Trends in Immunolabelled and Related Techniques (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535105701 , 9789535152880
    Language: English
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Proteins
    Abstract: The book is coined to provide a professional insight into the different trends of immunoassay and related techniques. It encompasses 22 chapters which are grouped into two sections. The first section consists of articles dealing with emerging uni-and-multiplex immunolabelled methods employed in the various areas of research. The second section includes review articles which introduce the researchers to some immunolabelled techniques which are of vital significance such as the use of the conjugates of the Staphylococcus aureus protein "A" and the Streptococcus Spps. protein "G" in immunolabelled assay systems, the use of bead-based assays and an overview on the laboratory assay systems. The book provides technological innovations that are expected to provide an efficient channel for developments in immunolabelled and related techniques. It is also most useful for researchers and post-graduate students, in all fields, where immunolabelled techniques are applicable
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  • 45
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    Proteomic Applications in Biology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533076133 , 9789535151968
    Language: English
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Proteins
    Abstract: The past decade has seen the field of proteomics expand from a highly technical endeavor to a widely utilized technique. The objective of this book is to highlight the ways in which proteomics is currently being employed to address issues in the biological sciences. Although there have been significant advances in techniques involving the utilization of proteomics in biology, fundamental approaches involving basic sample visualization and protein identification still represent the principle techniques used by the vast majority of researchers to solve problems in biology. The work presented in this book extends from overviews of proteomics in specific biological subject areas to novel studies that have employed a proteomics-based approach. Collectively they demonstrate the power of established and developing proteomic techniques to characterize complex biological systems
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  • 46
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    Protein Kinases (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106401 , 9789535153023
    Language: English
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Proteins
    Abstract: Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development
    Note: English
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  • 47
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    Crosstalk and Integration of Membrane Trafficking Pathways (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105152 , 9789535152729
    Language: English
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Proteins
    Abstract: Membrane traffic is a broad field that studies the complex exchange of membranes that occurs inside the cell. Protein, lipids and other molecules traffic among intracellular organelles, and are delivered to, or transported from the cell surface by virtue of membranous carriers generally referred as "transport intermediates". These carriers have different shapes and sizes, and their biogenesis, modality of transport, and delivery to the final destination are regulated by a multitude of very complex molecular machineries. A concept that has clearly emerged in the last decade is that each membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways. The aim of this book is to provide a general overview of the extent of this crosstalk
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  • 48
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    Embryonic Stem Cells : Basic Biology to Bioengineering (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533072784 , 9789535164869
    Language: English
    Pages: 1 Online-Ressource (492 p.)
    Keywords: Proteins
    Abstract: Embryonic stem cells are one of the key building blocks of the emerging multidisciplinary field of regenerative medicine, and discoveries and new technology related to embryonic stem cells are being made at an ever increasing rate. This book provides a snapshot of some of the research occurring across a wide range of areas related to embryonic stem cells, including new methods, tools and technologies; new understandings about the molecular biology and pluripotency of these cells; as well as new uses for and sources of embryonic stem cells. The book will serve as a valuable resource for engineers, scientists, and clinicians as well as students in a wide range of disciplines
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  • 49
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    Stem Cells in Clinic and Research (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533077970 , 9789535164555
    Language: English
    Pages: 1 Online-Ressource (818 p.)
    Keywords: Proteins
    Abstract: Based on our current understanding of cell biology and strong supporting evidence from previous experiences, different types of human stem cell populations are capable of undergoing differentiation or trans-differentiation into functionally and biologically active cells for use in therapeutic purposes. So far, progress regarding the use of both in vitro and in vivo regenerative medicine models already offers hope for the application of different types of stem cells as a powerful new therapeutic option to treat different diseases that were previously considered to be untreatable. Remarkable achievements in cell biology resulting in the isolation and characterization of various stem cells and progenitor cells has increased the expectation for the development of a new approach to the treatment of genetic and developmental human diseases. Due to the fact that currently stem cells and umbilical cord banks are so strictly defined and available, it seems that this mission is investigationally more practical than in the past. On the other hand, studies performed on stem cells, targeting their conversion into functionally mature tissue, are not necessarily seeking to result in the clinical application of the differentiated cells; In fact, still one of the important goals of these studies is to get acquainted with the natural process of development of mature cells from their immature progenitors during the embryonic period onwards, which can produce valuable results as knowledge of the developmental processes during embryogenesis. For example, the cellular and molecular mechanisms leading to mature and adult cells developmental abnormalities are relatively unknown. This lack of understanding stems from the lack of a good model system to study cell development and differentiation. Hence, the knowledge reached through these studies can prove to be a breakthrough in preventing developmental disorders. Meanwhile, many researchers conduct these studies to understand the molecular and cellular basis of cancer development. The fact that cancer is one of the leading causes of death throughout the world, highlights the importance of these researches in the fields of biology and medicine
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  • 50
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    Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533071978 , 9789535164326
    Language: English
    Pages: 1 Online-Ressource (504 p.)
    Keywords: Proteins
    Abstract: Pluripotent stem cells have the potential to revolutionise medicine, providing treatment options for a wide range of diseases and conditions that currently lack therapies or cures. This book describes methodological advances in the culture and manipulation of embryonic stem cells that will serve to bring this promise to practice
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  • 51
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    Embryonic Stem Cells : Differentiation and Pluripotent Alternatives (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533076324 , 9789535165217
    Language: English
    Pages: 1 Online-Ressource (520 p.)
    Keywords: Proteins
    Abstract: The ultimate clinical implementation of embryonic stem cells will require methods and protocols to turn these unspecialized cells into the fully functioning cell types found in a wide variety of tissues and organs. In order to achieve this, it is necessary to clearly understand the signals and cues that direct embryonic stem cell differentiation. This book provides a snapshot of current research on the differentiation of embryonic stem cells to a wide variety of cell types, including neural, cardiac, endothelial, osteogenic, and hepatic cells. In addition, induced pluripotent stem cells and other pluripotent stem cell sources are described. The book will serve as a valuable resource for engineers, scientists, and clinicians as well as students in a wide range of disciplines
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  • 52
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    Embryonic Stem Cells : Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533071985 , 9789535164296
    Language: English
    Pages: 1 Online-Ressource (414 p.)
    Keywords: Proteins
    Abstract: Pluripotent stem cells have the potential to revolutionise medicine, providing treatment options for a wide range of diseases and conditions that currently lack therapies or cures. This book describes recent advances in the generation of tissue specific cell types for regenerative applications, as well as the obstacles that need to be overcome in order to recognize the potential of these cells
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  • 53
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    Embryonic Stem Cells : The Hormonal Regulation of Pluripotency and Embryogenesis (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533071961 , 9789535164302
    Language: English
    Pages: 1 Online-Ressource (690 p.)
    Keywords: Proteins
    Abstract: Pluripotency is a prerequisite for the subsequent coordinated differentiation of embryonic stem cells into all tissues of the body. This book describes recent advances in our understanding of pluripotency and the hormonal regulation of embryonic stem cell differentiation into tissue types derived from the ectoderm, mesoderm and endoderm
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