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  • MPI Ethno. Forsch.  (289)
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (289)
  • Oncology  (195)
  • Neurology & clinical neurophysiology  (94)
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  • MPI Ethno. Forsch.  (289)
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  • 1
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781837698493 , 9781837698516 , 9781837698509
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (108 p.)
    Schlagwort(e): Oncology ; MicroRNAs ; Angiogenesis ; Cytokine Gene Expression ; Checkpoint Inhibitors ; Antigenic Expression ; Immune Evasion ; DNA Vaccines ; Dendritic Cells ; Surgery ; Radiation Therapy ; Immune Modulators ; Gene Therapy
    Kurzfassung: A dramatic increase in knowledge regarding the molecular biology of gliomas has been established over the past few years, and this has led to the development of novel therapeutic strategies for these patients. This book describes some improvements in the surgical management of gliomas, including segmentation of brain MRI images using 4D MRI volumes to help with the diagnosis and monitoring of patients. Another novel topic reviewed involves the applications of photosensitizers and their efficacy in the generation of anti-tumor responses in photodynamic therapy. A review of the application of nanoparticles and their ability to deliver drugs to the tumor site with a reduction in systemic toxicity is another developing therapy discussed. The book also describes novel approaches involving the development of the use of microRNAs, which are non-coding RNAs that can be used as tumor suppressors that potentially can be developed to control the growth of gliomas. The book examines a large number of molecular interactions of signals in gliomas, which should lead to biomarkers of potential importance that could be manipulated in the development of clinical trials. Molecular networks need to be better understood for the development of therapeutic strategies. Finally, the book reviews immunotherapeutic strategies potentially useful in treating brain tumors that involve either poxviruses engineered to secrete IL-15- or IL-2-secreting fibroblasts transfected with tumor DNA. The stimulation of the immune system to selectively attack malignant cells should lead to the prolongation of survival of brain tumor patients without a decline in cognitive functions or other side effects. It is hoped that this new information will lead to improved and efficacious treatment strategies for these challenging tumors
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  • 2
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781837693375 , 9781837693399 , 9781837693382
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (86 p.)
    Schlagwort(e): Oncology ; Tumor Biology ; Treatment ; Indications ; Limits ; Fertility Sparing Management ; SLN ; Neoadjuvant Treatment ; Radical Surgery ; Targeted Therapy ; Endoscopic Surgery ; Robotic Surgery ; HPV
    Kurzfassung: Cervical Cancer - Recent Advances and New Perspectives is a review of interesting and clinically important advances in the tumor biology and treatment of cervical cancer. The book covers major aspects of scientific progress in the treatment of cervical cancer, focusing on new knowledge due to advances in molecular techniques, understanding of tumor biology, and innovative new treatment options. This book brings together an interesting collection of innovations in the treatment of cervical cancer and opinions from specialists in this field from around the world
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  • 3
    ISBN: 9781803558776 , 9781803558769 , 9781803558783
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (108 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Spinal cord injury is a severe scenario that may be caused by traumatic and non-traumatic vertebral or neurological disorders. Neurological impairment, chronic pain, and reduced quality of life may affect patients suffering from spinal cord injury, the onset of which may arise in an acute or chronic manner. Spinal surgeons, anesthetists, neuro-intensivists, neurologists, physiotherapists, rehabilitation medicine doctors, radiologists, neurophysiologists, and carers are all involved in the management of these patients. The chapters in this book combine a useful summary of this topic for non-expert readers with an in-depth study of medical and non-medical experts in the field
    Anmerkung: English
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  • 4
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781837687671 , 9781837687664 , 9781837687688
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (92 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This book provides a comprehensive overview of balance disorders. It discusses the initial approach to patients with balance disorders and presents important studies in the field. It is designed for general practitioners and specialist physicians
    Anmerkung: English
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  • 5
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803561295 , 9781803561288 , 9781803561301
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (222 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Glioblastoma (GBM) is a common and aggressive brain cancer with features of necrosis and endothelial proliferation in the histopathologic examination. Its presentation and management depend on tumor location, size, grade, and underlying histopathological characteristics. GBM tumors have clinical features of increased intracranial pressure, focal neurological deficits, or seizures (generalized or partial) with rapid progression. This book discusses GBM and its diagnosis, treatment, and management
    Anmerkung: English
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  • 6
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803564142 , 9781803564135 , 9781803564159
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (146 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Hepatocellular carcinoma (HCC) is a common tumor type arising from several distinct etiologies. It is usually diagnosed late and is difficult to treat. This volume presents an overview of selected aspects of HCC pathogenesis, and research aimed at developing diagnostic biomarkers. It points to a number of putative therapeutic targets, including signal transduction pathways, metabolic and epigenetic alterations in tumor cells, the tumor microenvironment, the gut microbiome, and functions of immune effector cells. Given the multi-step nature of most cancers, including HCC, future drug development will most likely require combination therapies that will simultaneously target multiple steps in hepatocarcinogenesis
    Anmerkung: English
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  • 7
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803563992 , 9781803563985 , 9781803564005
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (150 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Melanoma is an aggressive type of cancer for which treatment has dramatically evolved during the last 15 years, improving response and survival figures. This book, written by a diverse panel of experts, presents a description of the most relevant aspects of the epidemiology, diagnosis, local treatment, prognostic biomarkers and treatment for advanced disease, including the most recent research on novel molecules that are either approved or are undergoing clinical development. It includes insights on such challenging topics as when immunotherapy should be started in BRAF mutant patients, or which is the most appropriate treatment algorithm in those cases, as well as how to handle difficult and poor-prognosis melanoma cases, such as patients with brain metastases or patients with the uveal disease
    Anmerkung: English
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  • 8
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803566009 , 9781803565996 , 9781803566016
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (118 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: According to the World Health Organization, nearly 80% of people with epilepsy live in low- and middle-income countries and could live seizure-free if properly diagnosed and treated. Among the structural and genetic triggers that may lead to epilepsy are head trauma, abnormal synaptic connectivity, receptor subunits anomalies, and atypical ionic channel function. Developing brains are specifically susceptible to seizures for many reasons, for example, the presence of enhanced excitation due to the early production of excitatory neurotransmitters, and the fact that the inhibitory neurotransmitter GABA causes excitation early in life. These studies help to clarify why the very young brain is exceptionally prone to seizures. The chapters presented in this book describe how structural, genetic, infectious, and metabolic abnormalities can lead to epileptogenesis. Nevertheless, many underlying disease mechanisms that can lead to epilepsy remain unknown
    Anmerkung: English
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  • 9
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803560939 , 9781803560922 , 9781803560946
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (176 p.)
    Schlagwort(e): Oncology
    Kurzfassung: This book provides a comprehensive overview of multiple myeloma. It is organized into three sections with chapters addressing topics such as diagnosis, risk stratification, and management of multiple myeloma; treatment of multiple myeloma at diagnosis and at relapse; management of disease complications; and stem cell therapies, including autologous and allogeneic hematopoietic stem cell transplantation with a focus on autologous grafting using non-cryopreserved stem cells and performance of stem cell transplantation in outpatient settings
    Anmerkung: English
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  • 10
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839697807 , 9781839697791 , 9781839697814
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (126 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Paraplegia - New Insights reviews different and complementary aspects of one of the most common and catastrophic conditions. The book, edited and organized into five chapters, covers the most interesting and frequently encountered scientific material on spinal cord injury and paraplegia. It is hoped that readers will not only find answers to some of their questions but also gain a detailed understanding of paraplegia and holistic approaches to its treatment
    Anmerkung: English
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  • 11
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803561622 , 9781803561615 , 9781803561639
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (128 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Cancer mortality and morbidity are primarily brought on by metastasis. The ability of neoplastic cells to spread and colonize distant tissues is their most dangerous trait. Most malignancies are curable when they are detected early and have not spread outside of the original tissue. However, cancer is frequently incurable when tumor cells have created colonies elsewhere. Thus, the book content This book provides comprehensive information on cancer metastasis, along with references to specific cancer cases. The topics discussed include invasion by perturbation of cell-cell and cell-matrix adhesion, matrix degradation, motility, intravasation, extravasation, metastatic colonization, metastasis and angiogenesis. Molecular mechanisms, the metastatic process, and palliative bone metastasis therapy are also considered
    Anmerkung: English
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  • 12
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803561868 , 9781803561851 , 9781803561875
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (204 p.)
    Schlagwort(e): Oncology
    Kurzfassung: This book examines supportive and palliative care and quality of life in cancer patients. Chapters address such topics as anxiety, depression, and delirium in terminally ill cancer patients, ethics in palliative care, palliative care medications, assisted suicide and euthanasia, and much more
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  • 13
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803555416 , 9781803555409 , 9781803555423
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (164 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Squamous cell carcinoma remains a significant cause of morbidity and mortality. It is a heterogeneous disease with complex molecular abnormalities. Head and neck squamous cell carcinomas (SCC) represent the most frequent human solid tumors and are a major cause of cancer mortality. Highly heterogeneous tumors arise from closely interconnected epithelial cell populations whose intrinsic self-renewal potential is inversely related to the stratified differentiation program. Cancer prevention strategies are theoretically appealing although often difficult to implement, owing to the multifactorial pathogenesis of most cancers. This book focuses on significant variations of squamous cell carcinoma, including squamous cell carcinoma of the vagina, bladder, head and neck
    Anmerkung: English
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  • 14
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803567532 , 9781803567525 , 9781803567549
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (264 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Central nervous system (CNS) tumors are a heterogeneous group consisting of more than 100 tumor types originating from the brain, cerebellum, brain stem, spinal cord, and meninges. Despite the positive developments of recent years, especially in the treatment of high-grade brain tumors, treatment outcomes have not yet reached an acceptable level. However, due to advances in clinical and experimental studies, the genetic and molecular structures of many high-grade CNS tumors are now better understood. The World Health Organization’s 2021 Classification of CNS Tumors has aided the understanding of the genetic, molecular and immunological structures of these tumors as well as their interactions with their microenvironment. Targeted therapies and vaccines developed with immunotherapy protocols are promising developments. This book explores the natural history of CNS tumors and discusses relevant treatment protocols
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  • 15
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803569062 , 9781803569055 , 9781803569079
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (152 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Medical professionals and researchers in the field of leukemias are faced with the need to continuously update their knowledge in a wide range of areas, ranging from fundamental molecular processes and mechanisms to a thorough understanding of clinical features and modern approaches to achieve maximum therapeutic results. This book does not have the ambition to present comprehensively the problems of leukemias, but it is an attempt to acquaint the audience of specialists involved in clinical management and experimental research with some modern advances and concepts in the three main directions: biology, clinical presentation and treatment. The biological aspects of the origin, development and therapy resistance of leukemias are within the scope of the first section. Comprehensive and concise information on the clinical assessment and treatment of leukemia patients is provided, as well as on some specific interdisciplinary clinical scenarios such as leukemic retinopathy, in the second section. Finally, challenges, current standards and recent advances in the therapy of acute leukemias comprise the third section of the book
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  • 16
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803562858 , 9781803562841 , 9781803562865
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (194 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Thyroid cancer is the most common endocrine cancer, although it is relatively rare compared to other cancers. Standard treatment involves thyroidectomy and radioiodine administration followed by life-long thyroxine administration. However, until recently, there was no medical treatment for advanced thyroid cancer. Advances in the genetics of thyroid cancer and in the treatment of other forms of cancer with tyrosine kinase inhibitors have revolutionized the treatment of advanced thyroid cancer. This book provides a comprehensive overview of thyroid cancer. It is organized into two sections on genetics and treatment. Chapters address such topics as the genetic susceptibility to differentiated thyroid cancer, the molecular basis of radioiodine treatment in thyroid cancer, recent developments in the medical treatment of advanced thyroid cancer, systemic therapy in thyroid cancer, and much more
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  • 17
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803565828 , 9781803565811 , 9781803565835
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (146 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Cerebral palsy is a debilitating disease that affects the everyday life of patients and their caregivers. Understanding its pathophysiology, preventing avoidable factors, and effectively treating the disease with the most appropriate approach is paramount in the management of patients with cerebral palsy. This book presents up-to-date information about the etiology, pathophysiology, social aspects, and optimum care and treatment alternatives of this chronic condition
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  • 18
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781837695799 , 9781837695812 , 9781837695805
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (112 p.)
    Schlagwort(e): Oncology ; Neurofibromatosis 1 ; Schwannomatosis ; Risk Factors ; Neurofibromatosis 2 ; Epidemiology ; Diagnosis ; Cancer Therapies ; Physiological Dysfunction ; Chemotherapy ; Surgery ; Monitoring ; Gene Immunotherapy
    Kurzfassung: This book describes and discusses numerous new concepts and procedures for the diagnosis and management of all types of neurofibromatosis (NF). It includes five chapters that address numerous topics in the field, including the management of toxicities associated with NF treatment modalities. It provides useful information and data for both researchers and practitioners to develop new approaches for the management of NF
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  • 19
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839694707 , 9781839694691 , 9781839694714
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (118 p.)
    Schlagwort(e): Oncology ; immunotherapy ; genetics ; ultrasound ; mri ; targeted therapy ; epigenetic
    Kurzfassung: In the past decade, we have witnessed innovation in surgical treatment for renal cell carcinoma (RCC), including robotic platforms with integration of imaging approaches, and advances in targeted therapy, immunotherapy, and combination therapy to treat patients with advanced RCC. This book presents updated information on the epidemiology, genetics, diagnosis, screening, and advances in the treatment and management of RCC. It is a useful resource for any clinician involved in the management of patients with RCC, as well as other physicians, researchers, and patients
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  • 20
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803559223 , 9781803559216 , 9781803559230
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (128 p.)
    Schlagwort(e): Oncology ; pancreas ; obesity ; epidemiology ; risk factors ; screening ; pathology
    Kurzfassung: Pancreatic Cancer - Updates in Pathogenesis, Diagnosis and Therapies presents the most recent knowledge on pancreatic cancer, which is a deadly, challenging and catastrophic tumor with a high mortality rate. It is the seventh leading cause of cancer-related mortality worldwide. Pancreatic cancer can be diagnosed clinically, by laboratory measures, by imaging, and by pathological detection. Understanding tumor pathogenesis as well as tumor risk factors is necessary for successful treatment, as is early detection and multidisciplinary treatment. This book provides a comprehensive overview of pancreatic cancer in four sections. Chapters address such topics as prevention, screening, and detection; pathogenesis and risk factors; and pathology and management
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  • 21
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839693809 , 9781839693793 , 9781839693816
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (124 p.)
    Schlagwort(e): Oncology ; cancer ; metabolism ; lung cancer ; nutrients ; minimally invasive surgery ; liquid biopsy
    Kurzfassung: This book offers outstanding approaches to understanding the role of the tumor microenvironment (TME) in cancer development and metastasis. The TME, with its multifaced role, is fundamental in the control and exacerbation of almost all cancer types. The outcome of many solid tumors is dependent on the modulation of the TME. Local tumor immunity, which is crucial in the control of cancer promotion, is one of the leading compounds of the TME. This book presents new insights and provides detailed and updated descriptions of the role of the TME in the control and the development of almost all cancer types. This book is an authentic source of knowledge, useful for researchers, medical doctors, students, and all individuals interested in understanding the mechanisms of cancer control and development
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  • 22
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839689635 , 9781839689628 , 9781839689642
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (142 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is a major monogenic neurocutaneous disorder. The NF1 gene encodes the protein neurofibromin whose dysfunction promotes tumorigenesis in central and peripheral neuronal tissues. In addition to inducing the formation of cutaneous pigmented lesions or neurofibromas, NF1 affects multiple organ systems, resulting in neurological and psychiatric disorders, orthopedic conditions, and impaired endocrine functions. This book examines the fundamental, clinical, and basic aspects of NF1 over three sections and nine chapters. Topics addressed include bone lesions in children with NF1, diffuse neurofibromatous tissue, seizures in adults with NF1, Ras-GAP function of neurofibromin, endocrine disorders characteristic of NF1, and more
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  • 23
    ISBN: 9781803553610 , 9781803553603 , 9781803553627
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (120 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Diagnostics and diseases related to the cerebrovascular system are constantly evolving and updating. 3D augmented reality or quantification of cerebral perfusion are becoming important diagnostic tools in daily practice and the role of the cerebral venous system is being constantly revised considering new theories such as that of "the glymphatic system." This book provides updates on models, diagnosis, and treatment of diseases of the cerebrovascular system
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  • 24
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838808372 , 9781838808365 , 9781838809676
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (130 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This book is about spinocerebellar ataxia (SCA), which is among the most challenging pathologies in the neurological landscape. It covers basic concepts, functional classification, and new approaches to medical and non-medical treatment including rehabilitation/palliative care approaches. The volume also describes a wide spectrum of generalities and particularities about various forms of clinical and genetic presentations of ACS that have life-threatening characteristics and long-standing presentation with tremendous variability in presentation and clinical severity. In addition, the book presents important aspects of cerebellar anatomy, nutrition impact, genetic subtypes, and functional classification of medical and non-medical interventions related to stem cells, rehabilitation, and palliative care
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  • 25
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839681127 , 9781839681110 , 9781839681172
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (222 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Lymphoma is a group of malignant diseases caused by the clonal proliferation of lymphocytes. Current treatment options include chemotherapy, radiotherapy, and bone marrow/stem cell transplantation. Development of new treatment options for cancer medications include small molecules and monoclonal antibodies for immunotherapy. In addition, the discovery of new phytochemical agents used in complementary and alternative medicine adds perspective to the treatment of lymphoma. This book highlights recent developments in the treatment of lymphoma. Chapters discuss different types of lymphomas, such as follicular lymphoma, gastrointestinal lymphoma, splenic B-cell lymphoma, and others, as well as the available treatment options for each
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  • 26
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839696961 , 9781839696954 , 9781839696978
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (182 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Cerebrospinal fluid is an essential, clear, and colorless liquid essential for maintaining homeostasis of the brain and neuronal functioning. Its secretion in adults ranges from 400 to 600 ml per day and it is renewed about four or five times daily. Cerebrospinal fluid is mainly reabsorbed from arachnoid granulations. Any disruption in this well-regulated system, such as overproduction, decreased absorption, or obstruction, could lead to hydrocephalus. This book contains essential knowledge about cerebrospinal fluid anatomy and physiology, pathologies related to cerebrospinal fluid, and treatment strategies for cerebrospinal fluid disorders
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  • 27
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839699122 , 9781839699115 , 9781839699139
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (214 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: The hippocampus is a bicortical structure with extensive fiber connections with multiple brain regions. It is involved in several functions, such as learning, memory, attention, emotion, and more. This book covers various aspects of the hippocampus including cytoarchitecture, functions, diseases, and treatment. It highlights the most advanced findings in research on the hippocampus. It discusses circuits, pattern formation process of grid cells, and zinc dynamics of the hippocampus. The book also addresses the tau pathology and circRNAs related to Alzheimer's disease and potential treatment strategies. It is a useful resource for general readers, students, and researchers
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  • 28
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789846713 , 9781789846706 , 9781789856576
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (136 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Oral cancer is a common disease with a high incidence of morbidity and mortality. Despite technological advancements in diagnosis and treatment, the five-year survival rate is low. Researchers worldwide are attempting to identify new and novel methods for early diagnosis and better treatment of oral cancer to improve survival rate and quality of life post recovery. This book examines current concepts in oral cancer and emphasizes future perspectives for diagnosis and treatment of disease for better clinical outcomes and patient care
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  • 29
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839693076 , 9781839693069 , 9781839693083
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (276 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Though the treatment of central nervous system (CNS) tumors has been challenging, new advances have helped us better understand the molecular and genetic makeup of many tumor types, and new chemotherapies and immunotherapies have extended survival in patients with aggressive primary CNS tumors. This book discusses pediatric and adult tumors of the CNS, the classification schemes used to categorize them, advances in surgical techniques, and several important genetic alterations found in these tumors. We hope this book contributes to the reader's understanding of these tumors and provides the most up-to-date and cutting-edge discoveries in this exciting field
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  • 30
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839691119 , 9781839691102 , 9781839691126
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (202 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Hepatocellular carcinoma (HCC) represents one of the most significant global health issues, given its high prevalence and the challenging nature and physiology of the liver and hepatic surgery, in its many forms. This means that the most appropriate management for HCC should incorporate a multidisciplinary approach, combining the expertise from several different specialties. This book showcases the various steps in the development, diagnosis, staging, and management of HCC and provides views and thoughts from true experts in the field. As such, it is a useful resource for any physician or surgeon, whether training or practicing, who is interested in caring for patients with HCC
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  • 31
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803550312 , 9781803550305 , 9781803550329
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (134 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: The recent and ongoing COVID-19 pandemic has changed societies and research around the world. As such, this new book examines the latest developments in the field of neuroscience related to these changes. It includes six chapters in two sections: “COVID-19 Effects: Neurology, Neuroimmunology, Neurogenesis” and “Molecular and Cellular Neurochemistry.” The first section includes chapters that address such topics as COVID’s effect on adult neurogenesis, neurological manifestations of COVID-19, and COVID-19 and seizures. Chapters in the second section discuss peripheral biomarkers in multiple sclerosis, amino acids as neurotransmitters, advancements in RNA sequencing technologies, and more
    Anmerkung: English
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  • 32
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803560601 , 9781803560595 , 9781803560618
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (134 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Traumatic brain injury (TBI) has the highest incidence of all common neurological dysfunctions and is a risk factor for a variety of neurological diseases. TBI is a major public health burden and the care of TBI patients is difficult. This book provides a comprehensive overview of TBI, addressing progress and needs in research as well as challenges in treatment. Chapters address such topics as emergency room airway management in TBI, craniocerebral injury in pediatric patients, traumatic optic neuropathy, and more
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  • 33
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803560694 , 9781803560687 , 9781803560700
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (286 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This book discusses timely topics in the field of neurophysiology ranging from descriptions of nerve cells and glial cells to neural networks, sensory processing, neuroplasticity, neuropathophysiology, and human behavior. As such, all organizational levels of the nervous system are considered in one or more of the book’s twelve chapters. The chapters review or present novel findings and provide the reader with an overview of the current state of the art of neurophysiology research. They discuss research advances in different brain regions and experimental models. In addition, the book contributes to the training of current and future neuroscientists and, hopefully, will lead us on the path to curing some of the biggest challenges in human health
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  • 34
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803561325 , 9781803561318 , 9781803561332
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (218 p.)
    Schlagwort(e): Oncology
    Kurzfassung: From surgery to chemotherapy and radiotherapy, attempts to conquer colorectal cancer have been ongoing for a century. Due to these efforts, the mortality rate of colorectal cancer has decreased by about 3% per year for the past 10 years. Progress in reducing mortality from colorectal cancer can be accelerated by improving screening and the use of standard care in all populations. In recent years, advanced knowledge and technologies for better efficiency in targeting colorectal cancer have been developed to improve conventional therapeutics or to propose new therapies as standard regimens. This book discusses diagnostics as well as surgical techniques using robotics, immunotherapy, and radiology-based therapy for colorectal cancer. The section on diagnostics provides information on proteomics, organoid culture techniques, and various candidate markers. The section on treatment discusses robotic surgical techniques for rectal cancer care and multidisciplinary approaches for colorectal cancer treatment. The book also examines the latest in supportive care from a nutritional and metabolic point of view
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  • 35
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803557243 , 9781803557236 , 9781803557250
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (140 p.)
    Schlagwort(e): Oncology
    Kurzfassung: This book aims to foster collaboration between world-class bench scientists and clinicians in the fields of oncology, surgery, and pathology as they come together to highlight the complexity and diversity of soft tissue tumors as well as recent advances in their diagnosis and clinical management
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  • 36
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839627019 , 9781839627002 , 9781839627026
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (200 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This book elucidates the key principles of cerebrovascular diseases (CVDs) in three sections. The first section addresses relevant pathophysiological aspects, diagnosis, treatment, and complications of CVDs, the second section examines CVDs in resource-poor settings and the geriatric population, and the final section discusses atrial fibrillation and cryptogenic stroke
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  • 37
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839693441 , 9781839693434 , 9781839693458
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (138 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This Edited Volume Alzheimer’s Disease is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field. The book comprises single chapters authored by various researchers and edited by an expert in the field, working on Alzheimer’s disease and dementia with cutting-edge technology. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in this research area, and opening new possible research paths for further novel developments
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  • 38
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803558356 , 9781803558349 , 9781803558363
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (164 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Tumor angiogenesis is critical for tumor growth and progression. It is a multistep and complicated process, and the mechanism underlying tumor angiogenesis is not fully elucidated. Recent advances in tumor angiogenesis research have led to improved diagnosis, drug treatment, and clinical management of cancer. However, novel strategies for cancer treatment are urgently needed, especially biomarker discovery for diagnosis, prognosis, and targeted therapy. This book presents the most recent advances in tumor angiogenesis
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  • 39
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803553498 , 9781803553481 , 9781803553504
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (142 p.)
    Schlagwort(e): Oncology
    Kurzfassung: This book is devoted to the state of the art, pitfalls and perspectives in the diagnosis and treatment of mesothelioma – a peculiar malignant tumour arising from mesothelial cells that line the pleura, the pericardium and the peritoneum. Mesothelioma is known for its strong association with asbestos exposure, difficult surgical treatment and dismal prognosis. However, recent years have yielded significant discoveries on, for example, germline mutations in BAP1 gene coding BRCA1-associated protein 1, the pathogenetic role of inflammation, and innovative treatment approaches such as immune checkpoint inhibitors. The volume is intended to summarise classic views and innovations in the pathogenetic concepts, diagnostics, treatment and scientific studies of mesothelioma, resulting in a comprehensive reference work as well as a source of ideas for relevant clinical and basic research
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  • 40
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781803554273 , 9781803554266 , 9781803554280
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (170 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Huntington’s Disease (HD) is a progressive neurodegenerative disease leading to a variety of neurological and psychiatric symptoms such as chorea, parkinsonism, oculomotor symptoms, cognitive decline, depression, suicidal ideation, and psychosis. Currently, only symptomatic treatment is available. In recent years, there has been a growing number of publications regarding pathophysiology, disease biomarkers, and possible avenues for causal therapy of HD. This book presents an overview of the most important research updates in the pathophysiology and treatment of HD, with particular reference to advances in HD neuropathology, neuroimaging, and biomarkers of HD. We also summarize possible new therapeutic targets, including cannabis-based medicine, cellular, and cell-free therapeutics. Importantly, researchers from different regions of the world have contributed to this volume as we wanted to create a balanced, inclusive, and interdisciplinary review of the topics. We hope that with this book readers will be offered a compact summary of up-to-date trends in HD research which, ultimately, will enable better diagnosis and treatment for HD patients
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  • 41
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839691089 , 9781839691072 , 9781839691096
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (170 p.)
    Serie: Biomedical Engineering 12
    Schlagwort(e): Oncology
    Kurzfassung: This book discusses the application of bioinformatics in cancer disease management. It covers general aspects of cancer as a disease but also as a success story in the translation of omics data in clinical settings. It provides an overview of the specific applications of bioinformatics tools in cancer epidemiology, prevention, and screening and in the identification of novel genetic and molecular biomarkers involved in cancer development. This is accomplished through the inclusion of numerous examples of the use of bioinformatics in precision oncology
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  • 42
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839688447 , 9781839688430 , 9781839688454
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (236 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: An estimated 50% to 80% of individuals with Parkinson's disease experience Parkinson's disease dementia (PDD). Based on the prevalence and clinical complexity of PDD, this book provides an in-depth update on topics including epidemiology, diagnosis, and treatment. Chapters discuss non-medical therapies and examine views on end-of-life issues as well. This book is a must-read for anyone interested in PDD whether they are a patient, caregiver, or doctor
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  • 43
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839698040 , 9781839698033 , 9781839698057
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (212 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Brain tumors comprise a spectrum of histological patterns. Their presentation and management depend on their location, size, and grade of lesions. This book is a collection of high-quality research work from global experts on brain tumors, including meningiomas, and their treatment
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  • 44
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839686542 , 9781839686535 , 9781839686559
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (182 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Demyelination disorders are among the most frequent neurological conditions. Types of these disorders include multiple sclerosis, Guillain Barré syndrome, diabetic peripheral neuropathy, entrapment neuropathies, and others, all of which can result in serious physical incapacity and diminished quality of life. This book examines various aspects of demyelination from clinical, diagnostic, and therapeutic points of view. Chapters address different types of demyelination diseases, their associated mechanisms, and pharmacologic and nonpharmacologic treatment approaches, among other topics
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  • 45
    ISBN: 9781839694165 , 9781839694158 , 9781839694172
    Sprache: Englisch
    Seiten: 1 Online-Ressource (56 p.)
    Schlagwort(e): Oncology
    Kurzfassung: The revival of DeltaRex-G (formerly Rexin-G)'”the first proactive tumor-hunting/tumor-killing biomedicine of this kind in history'”returned active tumor surveillance and a precision-guided 'silver bullet' (dnG1 killer gene) to the cancer clinic with 'Expanded Access' in 2019. Empowered by US Right-to-Try legislation, while honoring ethical principles of 'informed consent,' this unique graphic/picturesque presentation of clinical and translational medicine is intended for postmodern (post-Enlightenment) layman readers, including cancer patients, students, researchers, and future practitioners in the field of precision gene-based medicine. Confronting logical fallacies in popular opinion, the authors present newsworthy, up-to-date clinical research documenting the successful management of refractory metastatic cancers with tumor-targeted gene therapy vectors'”validating 'pathotropic' (disease-seeking) tumor targeting avant la lettre
    Anmerkung: English
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  • 46
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838805357 , 9781838805340 , 9781789848373
    Sprache: Englisch
    Seiten: 1 Online-Ressource (210 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer
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  • 47
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838811693 , 9781838811686 , 9781838811730
    Sprache: Englisch
    Seiten: 1 Online-Ressource (322 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia
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  • 48
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839623950 , 9781839623943 , 9781839623967
    Sprache: Englisch
    Seiten: 1 Online-Ressource (130 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Stroke continues to be a major public health issue. It is the third leading cause of death and disability across the globe. Its early identification and treatment along with prevention are major issues that confront a treating physician. We have understood the importance of early intervention and of the quote ‘time is brain’. Our endeavor now should be directed to the public at large and paramedics in particular. Although a stroke is a common condition, the availability of neurologists or stroke specialists is quite scarce. Today, management of a suspected case of stroke is done by a specialist team of medical and paramedical personnel. Advances in imaging, newer therapeutic agents, and endovascular management have revolutionized the management. Currently, we are witnessing a new era in the management of strokes and I am hopeful that continued research will get us to a satisfactory solution. This book along with another book from IntechOpen titled ‘Ischemic Stroke of Brain’ aims to improve the understanding of stroke medicine for postgraduate medical students in medicine and neurology who have an interest in stroke care
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  • 49
    ISBN: 9781839694165 , 9781839694158 , 9781839694172
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (56 p.)
    Schlagwort(e): Oncology
    Kurzfassung: The revival of DeltaRex-G (formerly Rexin-G)—the first proactive tumor-hunting/tumor-killing biomedicine of this kind in history—returned active tumor surveillance and a precision-guided “silver bullet” (dnG1 killer gene) to the cancer clinic with “Expanded Access” in 2019. Empowered by US Right-to-Try legislation, while honoring ethical principles of “informed consent,” this unique graphic/picturesque presentation of clinical and translational medicine is intended for postmodern (post-Enlightenment) layman readers, including cancer patients, students, researchers, and future practitioners in the field of precision gene-based medicine. Confronting logical fallacies in popular opinion, the authors present newsworthy, up-to-date clinical research documenting the successful management of refractory metastatic cancers with tumor-targeted gene therapy vectors—validating “pathotropic” (disease-seeking) tumor targeting avant la lettre
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 50
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789855425 , 9781789855418 , 9781839627491
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (214 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: In the last decade, diverse research areas have developed novel approaches to overcome dysfunctions after a spinal cord injury (SCI). Even though motor restoration attracts the most clinical attention, sensory, autonomic, and mental health are also aspects fundamental to improving the quality of life of SCI patients. Over four sections of therapeutic, rehabilitation, and technological approaches, this book examines preclinical and clinical studies using mesenchymal stem cells and pharmacological or electrical stimulation strategies. Chapters also address the impact of paraplegia and associated loss of autonomic functions, including bowel and sexual dysfunction, as well as the convergence of new technologies aimed at providing postural support and enhancing mobility
    Anmerkung: English
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  • 51
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789855425 , 9781789855418 , 9781839627491
    Sprache: Englisch
    Seiten: 1 Online-Ressource (214 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: In the last decade, diverse research areas have developed novel approaches to overcome dysfunctions after a spinal cord injury (SCI). Even though motor restoration attracts the most clinical attention, sensory, autonomic, and mental health are also aspects fundamental to improving the quality of life of SCI patients. Over four sections of therapeutic, rehabilitation, and technological approaches, this book examines preclinical and clinical studies using mesenchymal stem cells and pharmacological or electrical stimulation strategies. Chapters also address the impact of paraplegia and associated loss of autonomic functions, including bowel and sexual dysfunction, as well as the convergence of new technologies aimed at providing postural support and enhancing mobility
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 52
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839683886 , 9781839683879 , 9781839683893
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (140 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Moyamoya disease is a rare cerebrovascular disease most prevalent in East Asian countries. Thanks to new diagnostic capabilities, the number of cases discovered, including asymptomatic patients, has been increasing steadily. However, asymptomatic from the clinical point of view does not necessarily mean that there are no subjacent problems. Indeed, many patients harbour cognitive decline long before they exhibit clinical or radiological manifestations. The only effective treatment is surgical revascularization, either direct, indirect, or combined. Many posit that preventive surgical treatment should be considered even in asymptomatic moyamoya patients, particularly in the paediatric age group. This book expands on these ideas and examines the various aspects of this dreadful disease
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  • 53
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839680946 , 9781839680939 , 9781839680984
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (182 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Cerebral and Cerebellar Cortex – Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body
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  • 54
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839686214 , 9781839686207 , 9781839686221
    Sprache: Englisch
    Seiten: 1 Online-Ressource (126 p.)
    Schlagwort(e): Oncology
    Kurzfassung: This book deals with the diagnosis and treatment of multiple myeloma. Multiple myeloma is a plasma cell disorder, the prognosis of which has dramatically improved in the last years thanks to new immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies, in relapsed/refractory disease and a diagnosis. Chapters cover such topics as prognostic and predictive factors in newly diagnosed multiple myeloma, treatment approaches, antibody therapies, and three-dimensional (3D) models mimicking multiple myeloma bone marrow-microenvironment interactions
    Anmerkung: English
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  • 55
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839688683 , 9781839688676 , 9781839688690
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (260 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects
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  • 56
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838808792 , 9781838808785 , 9781838808808
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (148 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making it one of the most significant cancers responsible for productive years of life lost. Fortunately, there has been unprecedented progress in the treatment of advanced melanoma, largely through advances in understanding how to manipulate immune responses and target selective genetic mutations in melanoma patients. Clinical benefits to patients with advanced melanoma have been nevertheless limited by the development of innate and acquired drug resistance, and numerous efforts are focusing on the elucidation of these mechanisms. Combination strategies are being actively investigated to overcome drug resistance, by awakening existing anti-tumor mechanisms disabled by a cancer-promoting microenvironment. This book explores the advances and challenges associated with melanoma today, particularly those related to its diagnosis and management. It also proposes new avenues for therapeutic opportunities based on sustained research efforts and ever-growing technological advances. This is a relevant source of knowledge, very useful for researchers, medical doctors, health providers and all individuals interested in learning more about this devastating disease
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  • 57
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    ISBN: 9781838809072 , 9781838809065 , 9781838809089
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (164 p.)
    Serie: Biochemistry 24
    Schlagwort(e): Oncology
    Kurzfassung: For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and anticancer activity of protein kinase inhibitors on various cancer types. They also discuss new opportunities, challenges, and future perspectives in the field
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  • 58
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789855760 , 9781789855753 , 9781789856385
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (224 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts
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  • 59
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839622892 , 9781839622885 , 9781839622908
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (254 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: In the last two decades, there have been enormous advances in understanding epilepsy. Techniques such as electroencephalography, neuroimaging, neurosurgery, and neuropsychology are giving us a better understanding of the pathogenesis of epilepsy. Treatments such as antiepileptic drugs, surgery, and stem cell therapy are improving patient outcomes. This book presents the most current information on the physiopathology, diagnosis, and treatment of epilepsy
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  • 60
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839689482 , 9781839689475 , 9781839689499
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (130 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Pheochromocytoma, paraganglioma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. These neoplasms are associated with significant morbidity and mortality. Some international studies currently underway are researching and evaluating the presence of any similarities and differences between these tumors. Hopefully, future results will reveal several potential novel genes and pathways that might have major roles in the pathogenesis and progression of these neoplasms. This book discusses epidemiology, genetics, and treatment of these malignancies
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  • 61
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838811037 , 9781838811020 , 9781838811174
    Sprache: Englisch
    Seiten: 1 Online-Ressource (226 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Colorectal cancer is the third most common cancer diagnosed in both men and women worldwide. This book examines state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. It emphasizes the importance of a multidisciplinary approach involving multiple specialties, including surgery, gastroenterology, radiology, biology, oncology, radiotherapy, nuclear medicine, and physiotherapy
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  • 62
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    ISBN: 9781839629594 , 9781839629587 , 9781839629600
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (114 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Pancreatic cancer is one of the most lethal solid organ tumors with a poor five-year survival rate despite current oncological advances. The early and proper diagnosis of pancreatic cancer is of great importance for the improvement of the overall prognosis. This book provides an overview of the current challenges and states of pancreatic cancer and pancreatic neuroendocrine tumors, including information on diagnostic tools, treatment strategies, and mechanisms of pancreatic cancer therapy resistance
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  • 63
    ISBN: 9781839686696 , 9781839686689 , 9781839686702
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (166 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Neurological disorders are conditions affecting the central or peripheral nervous system, with undesirable consequences for the quality of life. This book highlights and discusses several approaches for managing these conditions and improving the functional capacity and quality of life of patients, including whole-body vibration exercise, biofeedback, sagittal plane spine alignment, allopathic and non-allopathic medications, phytotherapy, and more
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  • 64
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    ISBN: 9781839627972 , 9781839627965 , 9781839627989
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (174 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: ‘Connectivity and Functional Specialization in the Brain’ is a topic that describes nerve cells in terms of their anatomical and functional connections. The term connectome refers to a comprehensive map of neural connections, like a wiring diagram of an organism’s nervous system. Connectomics, the study of connectomes, can be applied to individual neurons and their synaptic connections, as well as to connections between neuronal populations or to functional and structural connectivity of different brain regions. This book addresses neural connectivity at these various scales in health and disease. The chapters review novel findings related to neuroanatomy and cell biology, neurophysiology, neural plasticity, changes of connectivity in neurological disorders, and sensory system connectivity. The book provides the reader with an overview of the current state-of-the-art of research of neural connectivity and focuses on the most important evidence-based developments in this area. Individual chapters focus on recent advances in specific areas of neural connectivity and in different brain regions. All chapters represent recent contributions to the rapidly developing field of neural connectivity
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  • 65
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    ISBN: 9781838819200 , 9781838819194 , 9781838819330
    Sprache: Englisch
    Seiten: 1 Online-Ressource (216 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This book covers the latest developments in the understanding and treatment of traumatic brain injury. Various world experts authored the chapters that comprise a wealth of updated information on intracranial pressure; monitoring and diagnostic methods; neuroinflammatory responses in traumatic brain injury; cerebral palsy and Covid-19-related brain disorder; pathogenesis and prevention of fetal, neonatal, infant, and child brain injury; hyperbaric oxygenation treatment; the engineering and modeling of head injury; systematic review on early-tracheostomy; intracranial aneurysm in tuberous sclerosis complex; and the neurobehavioral and cognitive aspects of brain injury. With these complex topics, every clinician, scientist, and researcher will find this book invaluable in understanding the latest improvements and advances in the diagnosis and treatment of traumatic brain injury
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  • 66
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    ISBN: 9781789856019 , 9781789854305 , 9781789856026
    Sprache: Englisch
    Seiten: 1 Online-Ressource (162 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology
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  • 67
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    ISBN: 9781839681554 , 9781839681547 , 9781839681561
    Sprache: Englisch
    Seiten: 1 Online-Ressource (118 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Mesothelioma is an aggressive cancer with very poor survival and lack of treatment options. This book, written by a diverse panel of experts, presents a description of the most relevant topics on epidemiology, diagnosis, biomarkers, and treatment updates, including interesting discussion on molecular mechanisms, prognostic features, and novel therapies that are either approved or under clinical development for this challenging disease. It also discusses and explains genetic biomarkers, as there may be a role for some nuclear regulatory genes and proteins in development of mesothelioma, although targeted therapies so far have had limited impact
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  • 68
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    ISBN: 9781789841589 , 9781789841572 , 9781839627941
    Sprache: Englisch
    Seiten: 1 Online-Ressource (276 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Numerous new concepts and procedures are reviewed and discussed in this book and allude to the transport of drugs to the brain. New radiation concepts are also presented, plus management of toxicities associated with both treatment modalities. It is the goal of this book to provide information and data that will be useful for both researchers and practitioners to develop new approaches for the management of CNS malignancies
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  • 69
    ISBN: 9781838804404 , 9781838804398 , 9781839692611
    Sprache: Englisch
    Seiten: 1 Online-Ressource (348 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action
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  • 70
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    ISBN: 9781839629747 , 9781839629730 , 9781839629754
    Sprache: Englisch
    Seiten: 1 Online-Ressource (222 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Mental disorders can result from disruption of neuronal circuitry, damage to the neuronal and non-neuronal cells, altered circuitry in the different regions of the brain and any changes in the permeability of the blood brain barrier. Early identification of these impairments through investigative means could help to improve the outcome for many brain and behaviour disease states.The chapters in this book describe how these abnormalities can lead to neurological and mental diseases such as ADHD (Attention Deficit Hyperactivity Disorder), anxiety disorders, Alzheimer’s disease and personality and eating disorders. Psycho-social traumas, especially during childhood, increase the incidence of amnesia and transient global amnesia, leading to the temporary inability to create new memories.Early detection of these disorders could benefit many complex diseases such as schizophrenia and depression
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  • 71
    ISBN: 9781789852585 , 9781789852578 , 9781838803803
    Sprache: Englisch
    Seiten: 1 Online-Ressource (192 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Neuropathies are one of the main neurological problems in everyday life, and they still have many partially understood parts and unknowns both for physicians and patients. Many systemic conditions may exist within them and therefore they may be difficult to treat. In this book we provide current knowledge concerning neuropathies, which we believe you will find interesting. The subject ‘’neuropathies’’ comprises a number of topics, and each and every one could be the subject of a textbook. On the other hand, this book was never designed as one. This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that the book may be an inspiration for many young investigators as well. It contains current approaches and knowledge and we sincerely believe and hope that it will answer your queries regarding new perspectives about neuropathy in general
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  • 72
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    ISBN: 9781789859683 , 9781789859676 , 9781838809980
    Sprache: Englisch
    Seiten: 1 Online-Ressource (216 p.)
    Schlagwort(e): Oncology
    Kurzfassung: This book is a collection of in-depth chapters on many aspects of contemporary cancer treatment. Written by experts worldwide, each chapter provides a detailed summary of the state-of-the art knowledge in the area, with extensive references and clear and informative diagrams. The volume is divided into two sections: “Basic Science” and “Clinical Challenges.” The five chapters in the first section cover MicroRNA, the role of angiogenesis in the tumor microenvironment, microbial metabolites in the gastrointestinal microenvironment, the role of dendritic cells in anti-tumor immunity, and challenges of current cancer biomarkers. The two chapters in the second section cover pediatric CNS tumors and the role of sentinel node biopsy in endometrial cancer. The information in this book is designed for cancer clinicians and interested readers to whom this knowledge is important for focusing research and improving patient outcomes
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  • 73
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    ISBN: 9781838807740 , 9781838807733 , 9781838808006
    Sprache: Englisch
    Seiten: 1 Online-Ressource (118 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission
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  • 74
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    ISBN: 9781838802929 , 9781838802912 , 9781839687723
    Sprache: Englisch
    Seiten: 1 Online-Ressource (274 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Clinical applications of neurostimulation or neuromodulation are experiencing rapid growth, driven by an evolution in neurotechnologies, the limitations of pharmacotherapy, and an improving understanding of brain physiology. New methods are promising for intractable or marginally tractable cognitive diseases and for adjunct therapies, as they offer greatly improved spatial and temporal resolution, thereby promising greater specificity and quicker recovery from disease. This book includes up-to-date and in-depth studies of many of these therapies, with chapters addressing their use in epilepsy, spasticity, pain, neurodegeneration, and spinal cord dysfunctions, among others, illustrating their versatility and therapeutic promise for cognitive dysfunction
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  • 75
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    ISBN: 9781839629389 , 9781838808433 , 9781839629396
    Sprache: Englisch
    Seiten: 1 Online-Ressource (142 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Motor functions such as muscle strength and joint range of motion as well as somatosensory functions that enable a person to interpret bodily sensation are necessary and important for physical activity and exercise. Somatosensory and Motor Research is divided into three sections: “Somatosensory Research,” “Motor Research,” and “Relationship between Somatosensory and Motor Research.” Written by researchers and experts in the field, chapters in this volume address basic anatomy and physiology, treatment of sensory disorders, motor function, and somatic sensations. This book contributes to the understanding of both motor nerve and sensory nerve function and their involvement in the acquisition of movement
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  • 76
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    ISBN: 9781789841404 , 9781789841398 , 9781789856521
    Sprache: Englisch
    Seiten: 1 Online-Ressource (100 p.)
    Schlagwort(e): Oncology
    Kurzfassung: According to the American Cancer Society, skin cancer is the most common cancer of all cancer types. Although melanoma represents only about 1% of all skin cancers, this tumour is still responsible for most skin cancer deaths and its incidence is steadily on the rise.The first section of this book covers the topic of genetic and epigenetic regulation of the melanoma progression. The second section focuses on special melanoma scenarios: melanoma in pregnancy and subungual melanoma. The third section follows the emerging trend of implementing mathematic models in skin cancer diagnosis. I hope that this book, written by international experts, will be a useful resource for both clinicians and researchers in the field
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  • 77
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    ISBN: 9781789843248 , 9781789843231 , 9781789855920
    Sprache: Englisch
    Seiten: 1 Online-Ressource (124 p.)
    Schlagwort(e): Oncology
    Kurzfassung: With the support of multinational specialists, each with different background and separate field of expertise in oncology, this book had the occasion to emerge and to offer physicians, researchers and academics efficient, well-organized and updated scientific information related to the characteristics and treatment modalities of squamous cell carcinoma. It provided in-depth information regarding the comprehension of the molecular interaction of signalling pathways and new phenotypes that might result and lead to further cell proliferation and metastases. It also emphasized on the management and individualization of treatment strategies in different types of SCC, applying molecular profiling and approved protocols in order to identify new treatment opportunities. This book also discussed the potential therapeutic modalities that might arise upon understanding and exploring the role of key regulatory proteins that govern the process of cutaneous SCC progression. And Lastly, it underlined the molecular aberrations present in SCC of different organs and the possibility of emerging new therapeutic drugs by targeting these abnormalities. It is really an innovative record that combined novel information from various medical sources and mixed it to become unified in its scientific profit
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  • 78
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    ISBN: 9781839624100 , 9781839624094 , 9781839624117
    Sprache: Englisch
    Seiten: 1 Online-Ressource (158 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: The book, Migraine, covers – to our best belief – the most important topics in migraine study, such as spontaneous primary headache, mostly from a clinical and therapeutic point of view. Special attention was paid to two hot topics in migraine problems: the chronic type of migraine and the new contemporary mode of treatment (for both episodic and chronic types) that is the use of monoclonal antibodies directed against the CGRP complex. The separate chapters cover the problem of medication overuse headaches, which is a growing condition among patients with migraine – especially the chronic migraine. The unique problem touched by the book is rarely discussed in literature of this field and it is the surgical attempts in the therapy of migraine. The authors of the book are widely recognized experts in migraines and related headaches that – we do believe – ensures a high quality of knowledge in the book. We hope that the presented monograph will be both attractive and helpful to all doctors interested not only in migraines but in other problems of idiopathic headaches
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  • 79
    ISBN: 9781789853605 , 9781789853599 , 9781789850994
    Sprache: Englisch
    Seiten: 1 Online-Ressource (356 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: “Brain circulation is a true road map that consists of large extended navigation territories and a number of unimagined and undiscovered routes.” Dr. Patricia Bozzetto Ambrosi This book combines an update on the review of cerebrovascular diseases in the form of textbook chapters, which has been carefully reviewed by Dr. Patricia Bozzetto Ambrosi, Drs. Rufai Ahmad and Auwal Abdullahi and Dr. Amit Agrawal, high-performance academic editors with extensive experience in neurodisciplines, including neurology, neurosurgery, neuroscience, and neuroradiology, covering the best standards of neurological practice involving basic and clinical aspects of cerebrovascular diseases. Each topic was carefully revised and prepared using smooth, structured vocabulary, plus superb graphics and scientific illustrations. In emphasizing the most common aspects of cerebrovascular diseases: stroke burden, pathophysiology, hemodynamics, diagnosis, management, repair, and healing, the book is comprehensive but concise and should become the standard reference guide for this neurological approach
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  • 80
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    ISBN: 9781838808334 , 9781838808327 , 9781838808341
    Sprache: Englisch
    Seiten: 1 Online-Ressource (80 p.)
    Schlagwort(e): Oncology
    Kurzfassung: The issue of asbestos exposure and the resulting health problems is now a global problem. The World Health Organization (WHO) has made recommendations on the eradication of asbestos-related diseases. However, malignant mesothelioma, mainly due to asbestos exposure, is a refractory malignant tumor, and technological innovation in diagnosis and treatment is required. In this context, this book describes the immunological effects of asbestos exposure, blood biomarkers, the pathology of malignant mesothelioma, and the status of immune checkpoint drugs in the treatment of malignant mesothelioma, along with the status of MMP mesothelioma. Concerns about health hazards associated with asbestos exposure may persist for many years to come. We hope this book will help researchers in this area
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  • 81
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    ISBN: 9781789843323 , 9781789843316 , 9781839685576
    Sprache: Englisch
    Seiten: 1 Online-Ressource (128 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Multiple sclerosis is among the most frequent neurological diseases, which affect seriously the quality of life of a constantly increasing number of patients, inducing physical and mental invalidism with indefinite perspectives. The ongoing investigation of the pathogenetic background and the inconclusive analysis of many pathophysiological mechanisms and serious neuropathological alterations of the disease are dominant crucial topics in the field of neurosciences, aimed at tracing a definite way to a therapeutic approach. The authors of this volume attempt to throw light on the labyrinth of multiple sclerosis, approaching the disease from the viewpoint of epidemiology, autoimmune reactions, symptomatology, mental and physical decline, diagnostic procedures, prognosis, and treatment. The authors submit herein, along with scientific data, their hope of contributing effectively to ameliorating the quality of life of those suffering from multiple sclerosis who wait patiently for the day of recovery
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  • 82
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    ISBN: 9781838805814 , 9781838805807 , 9781838805821
    Sprache: Englisch
    Seiten: 1 Online-Ressource (160 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS
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  • 83
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    ISBN: 9781789855302 , 9781789855296 , 9781838805760
    Sprache: Englisch
    Seiten: 1 Online-Ressource (120 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Neurofibromatosis, one of the most common genetic disorders, is a group of three conditions—Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis—that share some clinical features, such as the presence of cranial and spinal nerve sheet tumors. However, they differ in type of genetic disorder, age of clinical onset, manifestations, management and prognosis. Due to multisystem involvement, a multidisciplinary treatment approach that includes research is ideal. This book provides a systematic, comprehensive and updated outline of Neurofibromatosis. It is a useful reference for clinicians, researchers and students
    Anmerkung: English
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  • 84
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838803063 , 9781838803056 , 9781838802790
    Sprache: Englisch
    Seiten: 1 Online-Ressource (128 p.)
    Schlagwort(e): Oncology
    Kurzfassung: “Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored
    Anmerkung: English
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  • 85
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    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789853506 , 9781789853490 , 9781789851465
    Sprache: Englisch
    Seiten: 1 Online-Ressource (318 p.)
    Serie: Physiology 8
    Schlagwort(e): Oncology
    Kurzfassung: This book offers significant coverage on different aspects of cancer from risk factors to the mechanisms leading to tumor progression and metastasis. Although tremendous progress has been made in cancer research and treatment, cancer metastasis remains a major unmet clinical need. The life and death of many cancer patients hangs on the degree of metastasis. This book provides new perspectives for diagnosis and cancer therapy. It includes new technologies and a new basis for current cancer therapies. To guarantee the high quality of this book, important topics are included and rigorously discussed in a simple and authentic way. The book addresses important challenges governing tumor progression and metastasis and brings new responses to both diagnosis and therapy. This book is a great source of knowledge and will be useful for researchers, medical doctors, oncologists, graduate and medical students, continued medical educators, health care providers, and all individuals interested in understanding cancer and its challenges
    Anmerkung: English
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  • 86
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789238761 , 9781789238754 , 9781839622151
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (112 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Cholangiocarcinoma is a type of malignant tumor that affects the biliary system. It can arise anywhere in the bile ducts, manifesting itself as obstructive jaundice. It has an annual incidence of 1-2 cases per 100,000 people. One variety of the disease, the Klatskin tumor, occurs in the hepatic hilum and is characterized by poor prognosis. Generally, cholangiocarcinomas are slow-growing tumors with late metastases. Localized tumors are treated surgically, but intervention is discouraged when they are extensive. The disease affects both sexes, but most cases occur in patients aged over 60 years. Primary sclerosing cholangitis, chronic biliary infection, and choledochal cysts are associated with an increased risk of cholangiocarcinoma
    Anmerkung: English
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  • 87
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838812263 , 9781838812256 , 9781838812270
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (132 p.)
    Schlagwort(e): Oncology
    Kurzfassung: In this book the reader will find a collection of chapters written by different research teams describing different aspects of peripheral T-cell lymphoma pathobiology, classification, and treatment. This work is mainly addressed to researchers already working in this area, but it is also accessible to anyone with a scientific background who desires to have an updated overview of the recent progress in this domain. It will also be valuable to scientists and physicians who have become newly involved in this field. Each chapter is self-contained and can be read independently of the others. This book intends to provide highlights of the current research as well as the current gold standards for diagnosis and treatment of these diseases, showing the recent advances in the personalized approach to T-cell derived lymphomas
    Anmerkung: English
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  • 88
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789844009 , 9781789843996 , 9781839680434
    Sprache: Englisch
    Seiten: 1 Online-Ressource (106 p.)
    Schlagwort(e): Oncology
    Kurzfassung: A multidisciplinary understanding of the various processes leading to colorectal cancer progression is important for creating promising methods of therapy. Therefore it is necessary to scrutinize the progression of cancer and the therapeutic process through various academic theories. This book examines colorectal cancer - its prevention, pathogenesis, and treatment - through a multidisciplinary lens in an effort to advance understanding of the disease and improve therapeutic efficacy
    Anmerkung: English
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  • 89
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838811921 , 9781838811914 , 9781838811938
    Sprache: Englisch
    Seiten: 1 Online-Ressource (94 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Knowledge of the structure and function of the complex and interwoven network of nerves is inexhaustible and has not been fully determined. The physiological basis of many neuropathic symptoms continues to pursue experts in this field, and in many of the pathological changes related to neuropathies. In the last few decades, there has been increasing interest in new tools applied to diseases involving nerves of the nervous system, which have changed this state of affairs. Microscopic studies, new quantitative histometric methods, and refined physiologic techniques have already expanded our knowledge of structure and function of nerves and rapidly advancing techniques in the fields of immunology and molecular genetics to clarify entire categories of polyneuropathy. Although polyneuropathy is among the most challenging categories of neurological diseases, effective forms of treatment for polyneuropathy have been introduced during the last few decades. This book intends to provide the reader with a broad overview of polyneuropathy, featuring considerations and diagnostic approaches to patients, specific neuropathic syndromes and new related entities, pathogenic mechanisms, and pathological reactions brought to bear to the therapeutic and new clinical applications. All this is important evidence to support present and future directions in this challenging topic
    Anmerkung: English
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  • 90
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789847376 , 9781789847369 , 9781789859256
    Sprache: Englisch
    Seiten: 1 Online-Ressource (102 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches
    Anmerkung: English
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  • 91
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789238266 , 9781789238259 , 9781789843712
    Sprache: Englisch
    Seiten: 1 Online-Ressource (166 p.)
    Serie: Physiology 6
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Nowadays, neurodevelopmental disorders comprise a large proportion of mental health diagnoses. These disorders, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, include intellectual disabilities, communication disorders, autism spectrum disorders, attention deficit hyperactivity disorders, specific learning disorders, and motor disorders. Current research is pointing in the direction of schizophrenia, bipolar disorders, and other disorders being included in the category of neurodevelopmental disorders as well. There is a great deal of overlap among these disorders and they are best understood in a dimensional fashion. This book sets out the future of psychiatry in relation to these disorders and what is basically a new understanding of psychiatry in recent decades. Chapters cover topics such as early recognition of schizophrenia, epilepsy, and the genetics of ataxia telangiectasia. Also included is an examination of the complex issue of systems biology and neurodevelopment
    Anmerkung: English
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  • 92
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838812348 , 9781838812331 , 9781838812355
    Sprache: Englisch
    Seiten: 1 Online-Ressource (100 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: This Edited Volume Recent Advances in Neurodegeneration is a is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of neurodegeneration. The book comprises single chapters authored by various researchers and edited by an expert active in the neurodegeneration research area. All chapters are complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on neurodegeneration, and open new possible research paths for further novel developments
    Anmerkung: English
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  • 93
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789848632 , 9781789848625 , 9781789843668
    Sprache: Englisch
    Seiten: 1 Online-Ressource (112 p.)
    Schlagwort(e): Oncology
    Kurzfassung: In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy
    Anmerkung: English
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  • 94
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789238686 , 9781789238679 , 9781839625701
    Sprache: Englisch
    Seiten: 1 Online-Ressource (220 p.)
    Schlagwort(e): Neurology & clinical neurophysiology
    Kurzfassung: Epilepsy is the most common neurological disorder globally, affecting approximately 50 million people of all ages. It is one of the oldest diseases described in literature from remote ancient civilizations 2000-3000 years ago. Despite its long history and wide spread, epilepsy is still surrounded by myth and prejudice, which can only be overcome with great difficulty. The term epilepsy is derived from the Greek verb epilambanein, which by itself means to be seized and to be overwhelmed by surprise or attack. Therefore, epilepsy is a condition of getting over, seized, or attacked. The twelve very interesting chapters of this book cover various aspects of epileptology from the history and milestones of epilepsy as a disease entity, to the most recent advances in understanding and diagnosing epilepsy
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  • 95
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789840247 , 9781789840230 , 9781789844030
    Sprache: Englisch
    Seiten: 1 Online-Ressource (94 p.)
    Schlagwort(e): Oncology
    Kurzfassung: In the current practice of modern medicine, the treatment of infectious and nutritional disorders is well established. In contrast, currently genetic disorders/diseases and cancer constitute a substantial load in the clinic. The care of genetic-based diseases and cancer has become a major task in medical practices worldwide and it is unprecedented. It will be rare for any family to be entirely free of genetic disease, therefore genetic diseases impose a huge burden upon individuals, families, and societies. Modern medicine is at the crossroads in the new genomic era with the development of more and more modern technologies. Remarkable advances have been well achieved in defining and classifying these genetic-associated diseases. The identification of the genetic landscape of germ line mutations-associated leukemia caused by either inherited gene mutations or syndromes has led to a deep understanding of leukemogenesis, recognition of clinical diagnosis, and translation into clinical practice in its specific management strategies
    Anmerkung: English
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  • 96
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789845037 , 9781789845020 , 9781789846041
    Sprache: Englisch
    Seiten: 1 Online-Ressource (114 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Up to 70% of oral cancers are preceded by premalignant oral lesions, such as persistent red or white patches in the mouth. Survival rates for oral cancer can be improved through early detection. It is therefore essential that oral health professionals such as dentists, dental hygienists, dental therapists, and oral health therapists understand the importance of conducting a thorough oral screening examination for malignant and potentially malignant lesions as part of their routine clinical assessments, even in younger populations considered at lower risk for oral cancer. Key features of the book include: laser treatment techniques ,human genome sequencing, early detection and multidisciplinary approach ,management strategies and mechanisms of proliferation and energy metabolism in oral cancer
    Anmerkung: English
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  • 97
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789239423 , 9781789239416 , 9781839626579
    Sprache: Englisch
    Seiten: 1 Online-Ressource (176 p.)
    Schlagwort(e): Oncology
    Kurzfassung: The book Advances in Hematologic Malignancies presents new knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic, and genomic changes that have influenced the current outlook toward hematological malignancies. This book provides a unique, practical, and concise guide that is focused on the must-know points of diagnosis, prognosis, therapeutic management, and cutting edge clinical trial opportunities for each hematologic malignancy. Advances in Hematologic Malignancies is designed and organized as an essential reference source for the hematologist, hematologic oncologist, hematopathologist, and trainee
    Anmerkung: English
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  • 98
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789848090 , 9781789848083 , 9781839622199
    Sprache: Englisch
    Seiten: 1 Online-Ressource (134 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment
    Anmerkung: English
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  • 99
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838801762 , 9781838801755 , 9781789853834
    Sprache: Englisch
    Seiten: 1 Online-Ressource (78 p.)
    Schlagwort(e): Oncology
    Kurzfassung: The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer
    Anmerkung: English
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  • 100
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789239843 , 9781789239836 , 9781838818913
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (116 p.)
    Schlagwort(e): Oncology
    Kurzfassung: Thyroid cancer is being increasingly diagnosed nowadays. This situation has attracted the attention of scientists and physicians alike and new applications in diagnosis and treatment are being developed and used. There are many cases associated with thyroid cancer and in this book, thyroid cancer is examined in various aspects
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