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  • 2010-2014  (60)
  • 1965-1969
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (60)
  • Medical genetics  (60)
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  • 1
    Online-Ressource
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    Epigenetics and Epigenomics (2014)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535113638 , 9789535153917
    Sprache: Englisch
    Seiten: 1 Online-Ressource (220 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The book aims to provide an overview of current knowledge regarding epigenetics and epigenomics. Included are reviews on the role of epigenetics in the development and pathogenesis of the vascular endothelium and nervous system, as well as our current understanding of the potential etiologies of Autism Spectrum Disorders. Additional chapters are devoted to DNA methylation, genomic imprinting and human reproduction. A discussion of the role of the epigenome in cancer prevention and polyphenols is also included. Authors provide research findings from both human data and animal model studies. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of epigenetics and epigenomics
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  • 2
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    Genetic Manipulation of DNA and Protein : Examples from Current Research (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535109945 , 9789535153528
    Sprache: Englisch
    Seiten: 1 Online-Ressource (464 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research
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  • 3
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    Senescence and Senescence-Related Disorders (2013)
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    ISBN: 9789535109976 , 9789535153580
    Sprache: Englisch
    Seiten: 1 Online-Ressource (160 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions
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  • 4
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    Novel Gene Therapy Approaches (2013)
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    ISBN: 9789535109662 , 9789535170853
    Sprache: Englisch
    Seiten: 1 Online-Ressource (406 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancer
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  • 5
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    Down Syndrome (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110361 , 9789535171102
    Sprache: Englisch
    Seiten: 1 Online-Ressource (272 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Down syndrome, the most cutting-edge book in the field congenital disorders. This book features up-to-date, well referenced research and review articles on Down syndrome. Research workers, scientists, medical graduates and pediatricians will find it to be an excellent source for references and review. It is hoped that such individuals will view this book as a resource that can be consulted during all stages of their research and clinical investigations. Key features of this book are: Common diseases in Down syndrome Molecular Genetics Neurological Disorders Prenatal Diagnosis and Genetic Counselling Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents, relatives and health-care providers who work with infants and children with Down syndrome
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  • 6
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    Meiosis (2013)
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    ISBN: 9789535111979 , 9789535153856
    Sprache: Englisch
    Seiten: 1 Online-Ressource (134 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Meiosis is the key process underlying sexual reproduction in eukaryotes, occurring in single-celled eukaryotes and in most multicellular eukaryotes including animals and most plants. Thus meiosis is of considerable interest, both at the scientific level and at the level of natural human curiosity about sexual reproduction. Improved understanding of important aspects of meiosis has emerged in recent years and major questions are starting to be answered, such as: How does meiosis occur at the molecular level, How did meiosis and sex arise during evolution, What is the major adaptive function of meiosis and sex. In addition, changing perspectives on meiosis and sex have led to the question: How should meiosis be taught. This book proposes answers to these questions, with extensive supporting references to the current literature
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  • 7
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    Genetic Disorders (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535108863 , 9789535170617
    Sprache: Englisch
    Seiten: 1 Online-Ressource (354 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Human genetics is the medical field with the most rapid progress. This book aims to provide an overview on some of the latest developments in several genetic diseases. It contains 14 chapters focused on various genetic disorders addressing epidemiology, etiology, molecular basis and novel treatment options for these diseases. The chapters were written by 41 collaborators, from 8 different countries in Europe, Asia, and America, with great expertise in their field. Chapters are heterogeneous, offering a welcomed personalized view on each particular subject. The book does not offer a systematic overview of human genetic disorders. However, they are a valuable resource for medical practitioners, researchers, biologists and students in various medical sciences
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  • 8
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    New Research Directions in DNA Repair (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535111146 , 9789535153757
    Sprache: Englisch
    Seiten: 1 Online-Ressource (674 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair
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  • 9
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    Chromatin Remodelling (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110873 , 9789535153672
    Sprache: Englisch
    Seiten: 1 Online-Ressource (236 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The term "chromatin remodelling" is widely used to describe changes in chromatin structure which is controlled by histone-modifying enzymes, chromatin remodelling complexes, non-histone DNA-binding proteins and noncoding RNAs. Many human diseases such as cancer, various genetic syndromes, autism and infectious disease have been linked to the disruption of these control processes by genetic, environmental or microbial factors. Therefore, to unravel the mechanisms by which they operate is one of the most exciting and rapid developing fields of modern biology and will contribute to new ways in treatment of these diseases. The chapters in this book will focus on recent advances in our understanding of the mechanisms that govern the dynamic structural of chromatin, thereby providing important insights into gene regulation, DNA repair, and human diseases
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  • 10
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    Current Progress in Biological Research (2013)
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    Details
    ISBN: 9789535110972 , 9789535153689
    Sprache: Englisch
    Seiten: 1 Online-Ressource (396 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Current Progress in Biological Research presents new insights into key topics from different areas of the biological sciences. Some of the topics covered in the book are antibiotic susceptibility, genomic rearrangement, historical biogeography, biogeographic patterns, endemism and the use of microorganisms for pest control. The book is an interesting collection of 16 original research articles written by respected experts in their fields. It is hoped that readers will be stimulated and challenged by the contents of this book
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  • 11
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    Gene Therapy : Tools and Potential Applications (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110149 , 9789535153627
    Sprache: Englisch
    Seiten: 1 Online-Ressource (756 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The Gene Therapy field is living exciting times after more than 20 years of poor results. Scientist and clinicians working in the gene therapy field have encountered many problems in the past that are now starting to be solved. The development of safer and more efficient gene transfer vectors and the advances on the cell therapy field have open new opportunities to tackle different diseases. The aim of this book is to bring together information about the different gene therapy tools, the clinical successes of gene therapy and the future applications
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  • 12
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    Genes and Autoimmunity : Intracellular Signaling and Microbiome Contribution (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535110286 , 9789535171140
    Sprache: Englisch
    Seiten: 1 Online-Ressource (278 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity
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  • 13
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    The Mechanisms of DNA Replication (2013)
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    ISBN: 9789535109914 , 9789535153573
    Sprache: Englisch
    Seiten: 1 Online-Ressource (500 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations
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  • 14
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    Clinical Flow Cytometry : Emerging Applications (2012)
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    ISBN: 9789535105756 , 9789535152958
    Sprache: Englisch
    Seiten: 1 Online-Ressource (216 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: "Clinical Flow Cytometry - Emerging Applications" contains a collection of reviews and original papers that illustrate the relevance of flow cytometry for the study of specific diseases and clinical evaluations. The chapters have been contributed by authors from a wide variety of countries showing the broad application and importance of this technology in medicine. Examples include chapters on autoimmune disease, cancer, and the evaluation of new drugs. The book is intended to give newcomers a helpful introduction, but also to provide experienced flow cytometrists with novel insights and a better understanding of clinical cytometry
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  • 15
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    Binding Protein (2012)
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    ISBN: 9789535107583 , 9789535153191
    Sprache: Englisch
    Seiten: 1 Online-Ressource (216 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Proteins are essential for all cellular events. They bind or interact with additional players such as other proteins, peptides, DNA, and RNA to exert their functions. Revealing protein binding partners is important in understanding the mechanisms through which they function in the cells and the organism. These interactions are essential in the regulation of cell fates and could be important in drugs development. For example proteins can bind mRNA to regulate stability and translation. They also bind other proteins for degradation or proteolysis. These mRNAs and proteins could be involved in cellular processes such as cell survival or apoptosis. This book contains review articles dealing with protein interactions with the above mentioned factors. The enclosed articles could be informative and stimulating for readers interested in protein binding partners and the consequences of such interactions
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  • 16
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    Antimicrobial Agents (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535107231 , 9789535153177
    Sprache: Englisch
    Seiten: 1 Online-Ressource (434 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book contains precisely referenced chapters, emphasizing antibacterial agents with clinical practicality and alternatives to synthetic antibacterial agents through detailed reviews of diseases and their control using alternative approaches. The book aims at explaining bacterial diseases and their control via synthetic drugs replaced by chemicals obtained from different natural resources which present a future direction in the pharmaceutical industry. The book attempts to present emerging low cost and environmentally friendly drugs that are free from side effects studied in the overlapping disciplines of medicinal chemistry, biochemistry, microbiology and pharmacology
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  • 17
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    Mutations in Human Genetic Disease (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535107903 , 9789535153290
    Sprache: Englisch
    Seiten: 1 Online-Ressource (306 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Different types of mutation can vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture. The genomes of higher organisms are now known to contain "pervasive architectural flaws" in that certain DNA sequences are inherently mutation prone by virtue of their base composition, sequence repetitivity and/or epigenetic modification. In this volume, a number of different authors from diverse backgrounds describe how the nature, location and frequency of different types of mutation causing inherited disease are shaped in large part, and often in remarkably predictable ways, by the local DNA sequence environment
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  • 18
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    Aneuploidy in Health and Disease (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106081 , 9789535152965
    Sprache: Englisch
    Seiten: 1 Online-Ressource (258 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies
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  • 19
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    Genetic Diversity in Microorganisms (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100645 , 9789535143444
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (384 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Genetic Diversity in Microorganisms presents chapters revealing the magnitude of genetic diversity of microorganisms living in different environmental conditions. The complexity and diversity of microbial populations is by far the highest among all living organisms. The diversity of microbial communities and their ecologic roles are being explored in soil, water, on plants and in animals, and in extreme environments such as the arctic deep-sea vents or high saline lakes. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in microorganisms. The purpose of the book is to provide a glimpse into the dynamic process of genetic diversity of microorganisms by presenting the thoughts of scientists who are engaged in the generation of new ideas and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of microbial phylogeny, genetic diversity, and molecular biology
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  • 20
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    Viral Genomes : Molecular Structure, Diversity, Gene Expression Mechanisms and Host-Virus Interactions (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100980 , 9789535143512
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (316 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Viruses are small infectious agents that can replicate only inside the living cells of susceptible organisms. The understanding of the molecular events underlying the infectious process has been of central interest to improve strategies aimed at combating viral diseases of medical, veterinary and agricultural importance. Some of the viruses cause dreadful diseases, while others are also of interest as tools for gene transduction and expression and in non-poluting insect pest management strategies. The contributions in this book provide the reader with a perspective on the wide spectrum of virus-host systems. They are organized in sections based on the major topics covered: viral genomes organization, regulation of replication and gene expression, genome diversity and evolution, virus-host interactions, including clinically relevant features. The chapters also cover a wide range of technical approaches, including high throughput methods to assess genome variation or stability. This book should appeal to all those interested in fundamental and applied aspects of virology
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  • 21
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    Reviews on Selected Topics of Telomere Biology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535108498 , 9789535153399
    Sprache: Englisch
    Seiten: 1 Online-Ressource (306 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Telomeres, located at the ends of linear chromosomes, are essential for genome stability and integrity. Advances in telomere researches have linked telomere dysfunction with cellular aging and a number of age-related human diseases. Recent studies further expanded our knowledge of telomere functions - telomeres are shown to be important for microbial pathogen virulence and telomere proteins have important non-telomeric cellular functions. This book includes current opinions on selected aspects of telomere research and their implication, in hope to help us focus better on future studies and enhance our research progress
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  • 22
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    Muscular Dystrophy (2012)
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    ISBN: 9789535106036 , 9789535169949
    Sprache: Englisch
    Seiten: 1 Online-Ressource (556 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders. This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. This book discusses the currently available diagnostic approaches that have revolutionized clinical research. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed. Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies
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  • 23
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    Osteogenesis (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100300 , 9789535168096
    Sprache: Englisch
    Seiten: 1 Online-Ressource (310 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book provides an in-depth overview of current knowledge about Osteogenesis, including molecular mechanisms, transcriptional regulators, scaffolds, cell biology, mechanical stimuli, vascularization and osteogenesis related diseases. Hopefully, the publication of this book will help researchers in this field to decide where to focus their future efforts, and provide an overview for surgeons and clinicians who wish to be directed in the developments related to this fascinating subject
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  • 24
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    Autoimmune Diseases : Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106937 , 9789535170204
    Sprache: Englisch
    Seiten: 1 Online-Ressource (404 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases
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  • 25
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    DNA Sequencing : Methods and Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105640 , 9789535152804
    Sprache: Englisch
    Seiten: 1 Online-Ressource (186 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book illustrates methods of DNA sequencing and its application in plant, animal and medical sciences. It has two distinct sections. The one includes 2 chapters devoted to the DNA sequencing methods and the second includes 6 chapters focusing on various applications of this technology. The content of the articles presented in the book is guided by the knowledge and experience of the contributing authors. This book is intended to serve as an important resource and review to the researchers in the field of DNA sequencing
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  • 26
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    Recent Trends in Cytogenetic Studies : Methodologies and Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101789 , 9789535152231
    Sprache: Englisch
    Seiten: 1 Online-Ressource (158 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Recent Trends in Cytogenetic Studies - Methodologies and Applications deals with recent trends in cytogenetics with minute details of methodologies that can be adopted in clinical laboratories. The chapters deal with basic methods of primary cultures, cell lines and their applications; microtechnologies and automations; array CGH for the diagnosis of fetal conditions; approaches to acute lymphoblastic and myeloblastic leukemias in patients and survivors of atomic bomb exposure; use of digital image technology and using chromosomes as tools to discover biodiversity. While concentrating on the advanced methodologies in cytogenetic studies and their applications, authors have pointed out the need to develop cytogenetic labs with modern tools to facilitate precise and effective diagnosis to benefit the patient population
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  • 27
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    Congenital Anomalies : Case Studies and Mechanisms (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100751 , 9789535152088
    Sprache: Englisch
    Seiten: 1 Online-Ressource (144 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book is in essence a collection of essays which are state of the art in their respective areas of knowledge. They inform the reader of all sorts of mechanistic considerations when developing understanding of issues surrounding the origins of congenital abnormalities. These chapters are written by world renown authorities in this area of science and represent a wide range of expertise from a clinician perspective, through to genetic mechanisms. Unlike some books which take a formal textual, somewhat plodding way through pathophysiology here instead we have cut through chapters in which the student , or scientist or medic is lead to understand just how complex the origins can be via examples from different parts of the body. With the erudite chapters are relevant tables and other diagrams to help clarify the text . These chapters represent a starter text for the stimulus for further knowledge of what is an increasingly important area of human health
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  • 28
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    Functional Genomics (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535107279 , 9789535153160
    Sprache: Englisch
    Seiten: 1 Online-Ressource (212 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book titled "Functional Genomics" contains a selection of chapters focused on crucial topics in functional genomics, from the analysis of the genetic code, to the understanding of the role of the different genes and to the proteomic implications. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Covering all the aspects involved in such a broad theme as functional genomics and in all its applications would be impossible within the same book. The different chapters represent a brief introduction to the topic, connecting the most promising developments in functional genomics technologies, focusing on specific applications in biomedicine, agro-food technologies and zootechniques
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  • 29
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    DNA Methylation : From Genomics to Technology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535103202 , 9789535152446
    Sprache: Englisch
    Seiten: 1 Online-Ressource (402 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Epigenetics is one of the most exciting and rapidly developing areas of modern genetics with applications in many disciplines from medicine to agriculture. The most common form of epigenetic modification is DNA methylation, which plays a key role in fundamental developmental processes such as embryogenesis and also in the response of organisms to a wide range of environmental stimuli. Indeed, epigenetics is increasing regarded as one of the major mechanisms used by animals and plants to modulate their genome and its expression to adapt to a wide range of environmental factors. This book brings together a group of experts at the cutting edge of research into DNA methylation and highlights recent advances in methodology and knowledge of underlying mechanisms of this most important of genetic processes. The reader will gain an understanding of the impact, significance and recent advances within the field of epigenetics with a focus on DNA methylation
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  • 30
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    Spinocerebellar Ataxia (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105428 , 9789535169772
    Sprache: Englisch
    Seiten: 1 Online-Ressource (208 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The purpose of this book has been to depict as many biochemical, genetic and molecular advances as possible, in the vast field of the spinocerebellar ataxias
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  • 31
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    Studies in Population Genetics (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105886 , 9789535169895
    Sprache: Englisch
    Seiten: 1 Online-Ressource (180 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book deals with central concepts in population genetics, describing the main evolutionary processes that influence the allele frequency distribution and change. The different chapters discuss topics such as population size and structure, migration, inbreeding and interbreeding, mechanisms of extinction and speciation, along with different data techniques and molecular methods used for detecting DNA sequence variation in the study of genetic polymorphisms. Part of the book includes statistical and computational methods commonly used to process population genetics data, which constitute an essential tool for understanding the concepts discussed. The book will be a useful reference for graduate students and researchers working on population genetics, and other related areas including microbiology, genetics, molecular biology, ecology, anthropology and others
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  • 32
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    Meiosis : Molecular Mechanisms and Cytogenetic Diversity (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101185 , 9789535152187
    Sprache: Englisch
    Seiten: 1 Online-Ressource (474 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Meiosis, the process of forming gametes in preparation for sexual reproduction, has long been a focus of intense study. Meiosis has been studied at the cytological, genetic, molecular and cellular levels. Studies in model systems have revealed common underlying mechanisms while in parallel, studies in diverse organisms have revealed the incredible variation in meiotic mechanisms. This book brings together many of the diverse strands of investigation into this fascinating and challenging field of biology
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  • 33
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    Flow Cytometry : Recent Perspectives (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106265 , 9789535153030
    Sprache: Englisch
    Seiten: 1 Online-Ressource (512 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: "Flow Cytometry - Recent Perspectives" is a compendium of comprehensive reviews and original scientific papers. The contents illustrate the constantly evolving application of flow cytometry to a multitude of scientific fields and technologies as well as its broad use as demonstrated by the international composition of the contributing author group. The book focuses on the utilization of the technology in basic sciences and covers such diverse areas as marine and plant biology, microbiology, immunology, and biotechnology. It is hoped that it will give novices a valuable introduction to the field, but will also provide experienced flow cytometrists with novel insights and a better understanding of the subject
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  • 34
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    Apoptosis and Medicine (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535107019 , 9789535153115
    Sprache: Englisch
    Seiten: 1 Online-Ressource (288 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book looks at the latest research studies on apoptosis in medicine. It is divided into three sections for convenient and easy reading. The first section which comprises two chapters is an introduction of the subject of apoptosis to the uninitiated. The second section which comprises a single solitary chapter looks at apoptosis in normal physiology during bone resorption under mechanical stress. The third and the final section reviews apoptosis in a number of pathological conditions with an emphasis on cancer
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  • 35
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    Point Mutation (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535103318 , 9789535152507
    Sprache: Englisch
    Seiten: 1 Online-Ressource (354 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world
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  • 36
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    Genetics and Pathophysiology of Essential Hypertension (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535102823 , 9789535152347
    Sprache: Englisch
    Seiten: 1 Online-Ressource (248 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension
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  • 37
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    Analysis of Genetic Variation in Animals (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100935 , 9789535152149
    Sprache: Englisch
    Seiten: 1 Online-Ressource (374 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Analysis of Genetic Variation in Animals includes chapters revealing the magnitude of genetic variation existing in animal populations. The genetic diversity between and within populations displayed by molecular markers receive extensive interest due to the usefulness of this information in breeding and conservation programs. In this concept molecular markers give valuable information. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in animals and also, the detection of genes influencing economically important traits. The purpose of the book is to provide a glimpse into the dynamic process of genetic variation in animals by presenting the thoughts of scientists who are engaged in the generation of new idea and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of conservation biology, genetic diversity, and molecular biology
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  • 38
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    Methylation : From DNA, RNA and Histones to Diseases and Treatment (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535108818 , 9789535153412
    Sprache: Englisch
    Seiten: 1 Online-Ressource (312 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain
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  • 39
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    Senescence (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101444 , 9789535143406
    Sprache: Englisch
    Seiten: 1 Online-Ressource (864 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The book "Senescence" is aimed to describe all the phenomena related to aging and senescence of all forms of life on Earth, i.e. plants, animals and the human beings. The book contains 36 carefully reviewed chapters written by different authors, aiming to describe the aging and senescent changes of living creatures, i.e. plants and animals
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  • 40
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    Molecular Interactions (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100799 , 9789535152132
    Sprache: Englisch
    Seiten: 1 Online-Ressource (384 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: In a classical approach materials science is mainly dealing with interatomic interactions within molecules, without paying much interest on weak intermolecular interactions. However, the variety of structures actually is the result of weak ordering because of noncovalent interactions. Indeed, for self-assembly to be possible in soft materials, it is evident that forces between molecules must be much weaker than covalent bonds between the atoms of a molecule. The weak intermolecular interactions responsible for molecular ordering in soft materials include hydrogen bonds, coordination bonds in ligands and complexes, ionic and dipolar interactions, van der Waals forces, and hydrophobic interactions. Recent evolutions in nanosciences and nanotechnologies provide strong arguments to support the opportunity and importance of the topics approached in this book, the fundamental and applicative aspects related to molecular interactions being of large interest in both research and innovative environments. We expect this book to have a strong impact at various education and research training levels, for young and experienced researchers from both academia and industry
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  • 41
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    DNA Repair and Human Health (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533076126 , 9789535165330
    Sprache: Englisch
    Seiten: 1 Online-Ressource (808 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers
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  • 42
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    DNA Repair (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533076973 , 9789535151869
    Sprache: Englisch
    Seiten: 1 Online-Ressource (650 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair
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  • 43
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    Human Genetic Diseases (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533079363 , 9789535167679
    Sprache: Englisch
    Seiten: 1 Online-Ressource (300 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The genetics science is less than 150 years old, but its accomplishments have been astonishing. Genetics has become an indispensable component of almost all research in modern biology and medicine. Human genetic variation is associated with many, if not all, human diseases and disabilities. Nowadays, studies investigating any biological process, from the molecular level to the population level, use the "genetic approach" to gain understanding of that process. This book contains many diverse chapters, dealing with human genetic diseases, methods to diagnose them, novel approaches to treat them and molecular approaches and concepts to understand them. Although this book does not give a comprehensive overview of human genetic diseases, I believe that the sixteen book chapters will be a valuable resource for researchers and students in different life and medical sciences
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  • 44
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    Targets in Gene Therapy (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075402 , 9789535164548
    Sprache: Englisch
    Seiten: 1 Online-Ressource (448 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy
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  • 45
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    Gene Therapy Applications (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075419 , 9789535164531
    Sprache: Englisch
    Seiten: 1 Online-Ressource (504 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The aim of our book is to provide a detailed discussion of gene therapy application in human diseases. The book brings together major approaches: (1) Gene therapy in blood and vascular system, (2) Gene therapy in orthopedics, (3) Gene therapy in genitourinary system, (4) Gene therapy in other diseases. This source will make clinicians and researchers comfortable with the potential and problems of gene therapy application
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  • 46
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    DNA Replication and Related Cellular Processes (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533077758 , 9789535151586
    Sprache: Englisch
    Seiten: 1 Online-Ressource (314 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Since the discovery of the DNA structure researchers have been highly interested in the molecular basis of genome inheritance. This book covers a wide range of aspects and issues related to the field of DNA replication. The association between genome replication, repair and recombination is also addressed, as well as summaries of recent work of the replication cycles of prokaryotic and eukaryotic viruses. The reader will gain an overview of our current understanding of DNA replication and related cellular processes, and useful resources for further reading
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  • 47
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    Fundamental Aspects of DNA Replication (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533072593 , 9789535151579
    Sprache: Englisch
    Seiten: 1 Online-Ressource (320 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed. We hope that readers will find this book interesting, helpful and inspiring
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  • 48
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    Gene Duplication (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533073873 , 9789535144144
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (414 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The book Gene Duplication consists of 21 chapters divided in 3 parts: General Aspects, A Look at Some Gene Families and Examining Bundles of Genes. The importance of the study of Gene Duplication stems from the realization that the dynamic process of duplication is the “sine qua non” underlying the evolution of all living matter. Genes may be altered before or after the duplication process thereby undergoing neofunctionalization, thus creating in time new organisms which populate the Earth
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  • 49
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    DNA Replication : Current Advances (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075938 , 9789535144700
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (710 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The study of DNA advanced human knowledge in a way comparable to the major theories in physics, surpassed only by discoveries such as fire or the number zero. However, it also created conceptual shortcuts, beliefs and misunderstandings that obscure the natural phenomena, hindering its better understanding. The deep conviction that no human knowledge is perfect, but only perfectible, should function as a fair safeguard against scientific dogmatism and enable open discussion. With this aim, this book will offer to its readers 30 chapters on current trends in the field of DNA replication. As several contributions in this book show, the study of DNA will continue for a while to be a leading front of scientific activities
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  • 50
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    Genetic Transformation (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533073644 , 9789535144434
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (342 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: Genetic transformation of plants has revolutionized both basic and applied plant research. Plant molecular biology and physiology benefit from this power fool, as well as biotechnology. This book is a review of some of the most significant achievements that plant transformation has brought to the fields of Agrobacterium biology, crop improvement and, flower, fruit and tree amelioration. Also, it examines their impact on molecular farming, phytoremediation and RNAi tools
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  • 51
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    Non-Viral Gene Therapy (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533075389 , 9789535144083
    Sprache: Unbestimmte Sprache
    Seiten: 1 Online-Ressource (708 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book focuses on recent advancement of gene delivery systems research. With the multidisciplinary contribution in gene delivery, the book covers several aspects in the gene therapy development: various gene delivery systems, methods to enhance delivery, materials with modification and multifunction for the tumor or tissue targeting. This book will help molecular biologists gain a basic knowledge of gene delivery vehicles, while drug delivery scientist will better understand DNA, molecular biology, and DNA manipulation
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  • 52
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    Viral Gene Therapy (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533075396 , 9789535164388
    Sprache: Englisch
    Seiten: 1 Online-Ressource (464 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The development of technologies that allow targeting of specific cells has progressed substantially in recent years for several types of vectors, particularly viral vectors, which have been used in 70% of gene therapy clinical trials. Particular viruses have been selected as gene delivery vehicles because of their capacities to carry foreign genes and their ability to efficiently deliver these genes associated with efficient gene expression. This book is designed to present the most recent advances in viral gene therapy
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  • 53
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    Prenatal Diagnosis and Screening for Down Syndrome (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533073552 , 9789535164463
    Sprache: Englisch
    Seiten: 1 Online-Ressource (246 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book provides a concise yet comprehensive source of current information on Down syndrome. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. This book focuses on exciting areas of research on prenatal diagnosis - Down syndrome screening after assisted reproduction techniques, noninvasive techniques, genetic counselling and ethical issues. Whilst aimed primarily at research worker on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents and relatives of Down syndrome patients
    Anmerkung: English
    URL: kostenfrei
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  • 54
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    Selected Topics in DNA Repair (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533076065 , 9789535165361
    Sprache: Englisch
    Seiten: 1 Online-Ressource (584 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book is intended for students and scientists working in the field of DNA repair, focusing on a number of topics ranging from DNA damaging agents and mechanistic insights to methods in DNA repair and insights into therapeutic strategies. These topics demonstrate how scientific ideas are developed, tested, dialogued, and matured as it is meant to discuss key concepts in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair
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  • 55
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    Advances in the Study of Genetic Disorders (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533073057 , 9789535165750
    Sprache: Englisch
    Seiten: 1 Online-Ressource (486 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The studies on genetic disorders have been rapidly advancing in recent years as to be able to understand the reasons why genetic disorders are caused. The first Section of this volume provides readers with background and several methodologies for understanding genetic disorders. Genetic defects, diagnoses and treatments of the respective unifactorial and multifactorial genetic disorders are reviewed in the second and third Sections. Certainly, it is quite difficult or almost impossible to cure a genetic disorder fundamentally at the present time. However, our knowledge of genetic functions has rapidly accumulated since the double-stranded structure of DNA was discovered by Watson and Crick in 1956. Therefore, nowadays it is possible to understand the reasons why genetic disorders are caused. It is probable that the knowledge of genetic disorders described in this book will lead to the discovery of an epoch of new medical treatment and relieve human beings from the genetic disorders of the future
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  • 56
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    Genetics and Etiology of Down Syndrome (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533076317 , 9789535164609
    Sprache: Englisch
    Seiten: 1 Online-Ressource (342 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: This book provides a concise yet comprehensive source of current information on Down syndrome. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. This book has been divided into four sections, beginning with the Genetics and Etiology and ending with Prenatal Diagnosis and Screening. Inside, you will find state-of-the-art information on: 1. Genetics and Etiology 2. Down syndrome Model 3. Neurologic, Urologic, Dental & Allergic disorders 4. Prenatal Diagnosis and Screening Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents and relatives of Down syndrome patients
    Anmerkung: English
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  • 57
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    Gene Therapy : Developments and Future Perspectives (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533076171 , 9789535164418
    Sprache: Englisch
    Seiten: 1 Online-Ressource (368 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The aim of this book is to cover key aspects of existing problems in the field of development and future perspectives in gene therapy. Contributions consist of basic and translational research, as well as clinical experiences, and they outline functional mechanisms, predictive approaches, patient-related studies and upcoming challenges in this stimulating but also controversial field of gene therapy research. This source will make our doctors become comfortable with the common problems of gene therapy and inspire others to delve a bit more deeply into a topic of interest
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  • 58
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    Molecular Cloning : Selected Applications in Medicine and Biology (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533073989 , 9789535151616
    Sprache: Englisch
    Seiten: 1 Online-Ressource (338 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: The development of molecular cloning technology in the early 1970s created a revolution in the biological and biomedical sciences that extends to this day. The contributions in this book provide the reader with a perspective on how pervasive the applications of molecular cloning have become. The contributions are organized in sections based on application, and range from cancer biology and immunology to plant and evolutionary biology. The chapters also cover a wide range of technical approaches, such as positional cloning and cutting edge tools for recombinant protein expression. This book should appeal to many researchers, who should find its information useful for advancing their fields
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  • 59
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    RNA Processing (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533075570 , 9789535151593
    Sprache: Englisch
    Seiten: 1 Online-Ressource (260 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: RNA functions broadly as informational molecule, genome, enzyme and machinery for RNA processing. While these functions reflect ancient activities, they also remain vital components of contemporary biochemical pathways. In eukaryotic cells RNA processing impacts the biogenesis of RNA molecules of essentially every shape and function. The collection of articles in this volume describes the current state of understanding of the broad array of RNA processing events in animal and plant cells, key unanswered questions, and cutting edge approaches available to address these questions. Some questions discussed in this volume include, how viruses subvert the RNA processing machinery of the host cell, how the coordination of co-transcriptional RNA processing is regulated at the level of chromatin, the status of RNA processing in plant organelles, and how micro RNA machinery is biosynthesized and regulated
    Anmerkung: English
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  • 60
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    DNA Repair : On the Pathways to Fixing DNA Damage and Errors (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533076492 , 9789535151609
    Sprache: Englisch
    Seiten: 1 Online-Ressource (394 p.)
    Schlagwort(e): Medical genetics
    Kurzfassung: DNA repair is fundamental to all cell types to maintain genomic stability. A collection of cutting-edge reviews, DNA Repair - On the pathways to fixing DNA damage and errors covers major aspects of the DNA repair processes in a large variety of organisms, emphasizing foremost developments, questions to be solved and new directions in this rapidly evolving area of modern biology. Written by researchers at the vanguard of the DNA repair field, the chapters highlight the importance of the DNA repair mechanisms and their linkage to DNA replication, cell-cycle progression and DNA recombination. Major topics include: base excision repair, nucleotide excision repair, mismatch repair, double-strand break repair, with focus on specific inhibitors and key players of DNA repair such as nucleases, ubiquitin-proteasome enzymes, poly ADP-ribose polymerase and factors relevant for DNA repair in mitochondria and embryonic stem cells. This book is a journey into the cosmos of DNA repair and its frontiers
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