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  • 2015-2019  (342)
  • 1995-1999
  • 2015  (342)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (342)
  • 1
    ISBN: 9782889196784
    Sprache: Englisch
    Seiten: 1 Online-Ressource (290 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Vision is the process of extracting behaviorally-relevant information from patterns of light that fall on retina as the eyes sample the outside world. Traditionally, nonhuman primates (macaque monkeys, in particular) have been viewed by many as the animal model-of-choice for investigating the neuronal substrates of visual processing, not only because their visual systems closely mirror our own, but also because it is often assumed that “simpler” brains lack advanced visual processing machinery. However, this narrow view of visual neuroscience ignores the fact that vision is widely distributed throughout the animal kingdom, enabling a wide repertoire of complex behaviors in species from insects to birds, fish, and mammals. Recent years have seen a resurgence of interest in alternative animal models for vision research, especially rodents. This resurgence is partly due to the availability of increasingly powerful experimental approaches (e.g., optogenetics and two-photon imaging) that are challenging to apply to their full potential in primates. Meanwhile, even more phylogenetically distant species such as birds, fish, and insects have long been workhorse animal models for gaining insight into the core computations underlying visual processing. In many cases, these animal models are valuable precisely because their visual systems are simpler than the primate visual system. Simpler systems are often easier to understand, and studying a diversity of neuronal systems that achieve similar functions can focus attention on those computational principles that are universal and essential. This Research Topic provides a survey of the state of the art in the use of animal models of visual functions that are alternative to macaques. It includes original research, methods articles, reviews, and opinions that exploit a variety of animal models (including rodents, birds, fishes and insects, as well as small New World monkey, the marmoset) to investigate visual function. The experimental approaches covered by these studies range from psychophysics and electrophysiology to histology and genetics, testifying to the richness and depth of visual neuroscience in non-macaque species
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  • 2
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193790
    Sprache: Englisch
    Seiten: 1 Online-Ressource (267 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Reading is an integral part of life in today's information-driven societies. Since the pioneering work of Dejerine on "word blindness" in brain-lesioned patients, the literature has increased exponentially, from neuropsychological case reports to mechanistic accounts of word processing at the behavioural, neurofunctional and computational levels, tapping into diverse aspects of visual word processing. These studies have revealed some exciting findings about visual word processing, including how the brain learns to read, how changes in literacy impact upon word processing strategies, and whether word processing mechanisms vary across different alphabetic, logographic or artificial writing systems. Other studies have attempted to characterise typical and atypical word processes in special populations in order to explain why dyslexic brains struggle with words, how multilingualism changes the way our brains see words, and what the exact developmental signatures are that would shape the acquisition of reading skills. Exciting new insights have also emerged from recent studies that have investigated word stimuli at the system/network level, by looking for instance, at how the reading system interacts with other cognitive systems in a context-dependent fashion, how visual language stimuli are integrated into the speech processing streams, how both left and right hemispheres cooperate and interact during word processing, and what the exact contributions of subcortical and cerebellar regions to reading are. The contributions to this Research Topic highlight the latest findings regarding the different issues mentioned above, particularly how these findings can explain or model the different processes, mechanisms, pathways or cognitive strategies by which the human brain sees words. The introductory editorial, summarising the contributions included here, highlights how varieties of behavioural tests and neuroimaging techniques can be used to investigate word processing mechanisms across different alphabetic and logographic writing systems
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  • 3
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    ISBN: 9782889195978
    Sprache: Englisch
    Seiten: 1 Online-Ressource (91 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Complex systems are to be seen as typically having multiple levels of organization. For instance, in the behavioural and cognitive sciences, there has been a long lasting trend, promoted by the seminal work of David Marr, putting focus on three distinct levels of analysis: the computational level, accounting for the What and Why issues, the algorithmic and the implementational levels specifying the How problem. However, the tremendous developments in neuroscience knowledge about processes at different scales of organization together with the complexity of today cognitive theories suggest that there will hardly be only three levels of explanation. Instead, there will be many different degrees of commitments corresponding to the different granularities - from high-level (behavioural) models to low-level (neural and molecular) models of the cognitive research program. For instance, Bayesian approaches, that are usually advocated for formalizing Marr's computational level and rational behaviour, have even been adopted to model synaptic plasticity and axon guidance by molecular gradients. As a result, we can consider the behavioural scientist as dealing with models at a multiplicity of levels. The purpose of this Research Topic in Frontiers in Theoretical and Philosophical Psychology is to promote an approach to the role of the levels and explanation and models which is of interest for cognitive scientists, neuroscientists, psychologists, behavioural scientists, and philosophers of science
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  • 4
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193974
    Sprache: Englisch
    Seiten: 1 Online-Ressource (129 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as neurodegenerative diseases, cystic fibrosis, diabetes and cancer. It has recently emerged that virus infections can trigger the UPR but the relationship between virus infections and host UPR is intriguing. On one hand, UPR is harmful to the virus and virus has developed means to subvert the UPR. On the other hand, virus exploits the host UPR to assist in its own infection, gene expression, establishment of persistence, reactivation from latency and to evade the immune response. When this delicate balance of virus-host UPR interaction is broken down, it may cause diseases. This is particularly challenging for viruses that establish a chronic infection to maintain this balance. Each virus interacts with the host UPR in a different way to suit their life style and how the virus interacts with the host UPR can define the characteristic of a particular virus infection. Understanding how a particular virus interacts with the host UPR may pave the way to the design of a new class of anti-viral that targets this particular pathway to skew the response towards anti-virus. This knowledge can also be translated into the clinics to help re-design oncolytic virotherapy and gene therapy. In this research topic we aimed to compile a collection of focused review articles, original research articles, commentary, opinion, hypothesis and methods to highlight the current advances in this burgeoning area of research, in an attempt to provide an in-depth understanding of how viruses interact with the host UPR, which may be beneficial to the future combat of viral and human diseases
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  • 5
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    ISBN: 9782889194742
    Sprache: Englisch
    Seiten: 1 Online-Ressource (126 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Transfer cells are anatom ...
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  • 6
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196364
    Sprache: Englisch
    Seiten: 1 Online-Ressource (75 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The innate immune system ...
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  • 7
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196920
    Sprache: Englisch
    Seiten: 1 Online-Ressource (171 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Cerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and dendritic wiring. This wiring enables both near and distant cells to coordinate their responses and generate a rich variety of cognitions and behaviours. When the wiring is damaged through disease or trauma it may reorganize but this may lead to characteristic pathological behaviours. While there have been significant advances in mapping cortical connectivity, the organizing principles and function of this connectivity are not well understood. On the one hand, there appears to be general design constraints governing cortical wiring, as first recognised by Rámon y Cajal's in his laws of conduction, material, and volume conservation. Yet on the other hand, particular patterns of cortical wiring exist to serve specific functions. There is a wide gap in understanding how the response and connectivity properties of a single neuron contribute to emergent network functions such as in detecting perceptually relevant features. Unravelling this intimate causal relationship represents one of the major challenges in neuroscience. This Research Topic will examine progress in understanding cortical wiring principles. This Research Topic aims to draw together recent advances in methods and understanding as well as recent challenges to existing ideas about how cerebral cortex is wired. This is particularly timely because new automated techniques may soon yield huge datasets in need of explanation. Recent studies have, for instance, empirically evaluated Rámon y Cajal's conservation laws for cerebral cortex, while others have shown some unexpected connectivity features that may refine the traditional view of how corticocortical connections are organised with regard to functional representations of auditory, somatosensory and visual cortices. Understanding these data will help improve the fidelity of neural models of cerebral cortical function and take into account the diversity of connections at both micro- and mesoscopic scales not seen at such a depth before
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  • 8
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195053
    Sprache: Englisch
    Seiten: 1 Online-Ressource (127 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Telemedicine networks to support healthcare workers in resource-limited settings (often for humanitarian purposes) have evolved over the last decade or so in a largely autonomous way. Communication between them has been informal and relatively limited in scope. This situation could be improved by developing a comprehensive approach to the collection and dissemination of information.A recent review identified seven telemedicine networks, each of which had been in operation for at least five years and which provided store-and-forward telemedicine services to doctors in low- and middle-income countries. These networks provide clinically useful services and improved healthcare access. However, like much of telemedicine, the formal evidence for their cost-effectiveness remains weak.Topics of current research interest therefore include the cost-effectiveness of telemedicine in resource-limited settings. Outcomes data (and methods for gathering it) such as patient quality of life following a telemedicine episode, the knowledge-gain of healthcare staff involved in telemedicine, and staff recruitment and retention in rural areas are also of interest. Finally, there is little published information about the performance of these telemedicine networks (and methods for measuring it), about how best to manage them, and about how to share resources between them.A collection of articles reporting the current evidence supporting the use of telemedicine in resource-limited settings would build the evidence base and should provide a focus for future research. It would also serve to raise the profile of this potentially important research field
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  • 9
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    ISBN: 9782889193875
    Sprache: Englisch
    Seiten: 1 Online-Ressource (133 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The hippocampus mediates ...
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  • 10
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196371
    Sprache: Englisch
    Seiten: 1 Online-Ressource (112 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The Neural Theory of Visual Attention of Bundesen, Habekost, and Kyllingsbæk (2005) was proposed as a neural interpretation of Bundesen’s (1990) theory of visual attention (TVA). In NTVA, visual attention functions via two mechanisms: by dynamic remapping of receptive fields of cortical cells such that more cells are devoted to behaviorally important objects than to less important ones (filtering) and by multiplicative scaling of the level of activation in cells coding for particular features (pigeonholing). NTVA accounts for a wide range of known attentional effects in human performance and a wide range of effects observed in firing rates of single cells in the primate visual system and thus provides a mathematical framework to unify the 2 fields of research. In this Research Topic of Frontiers in Psychology, some of the leading theories of visual attention at both the cognitive, neuropsychological, and neurophysiological levels are presented and evaluated. In addition, the Research Topic encompasses application of the framework of NTVA to various patient populations and to neuroimaging as well as genetic and psychopharmacological studies
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  • 11
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197170
    Sprache: Englisch
    Seiten: 1 Online-Ressource (81 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The pathogenic mechanisms ...
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  • 12
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    ISBN: 9782889194360
    Sprache: Englisch
    Seiten: 1 Online-Ressource (97 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Endoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. A number of biochemical, physiological, or pathological stimuli can interrupt protein folding process, causing accumulation of unfolded or misfolded proteins in the ER lumen, a condition called “ER stress”. To cope with accumulation of unfolded or misfolded proteins, the ER has evolved a group of signaling pathways termed “Unfolded Protein Response (UPR)” or “ER stress response” to align cellular physiology. To maintain ER homeostasis, transcriptional regulation mediated through multiple UPR branches is orchestrated to increase ER folding capacity, reduce ER workload, and promote degradation of misfolded proteins. In recent years, accumulating evidence suggests that ER stress-triggered transcriptional reprogramming exists in many pathophysiological processes and plays fundamental roles in the initiation and progression of a variety of diseases, such as metabolic disease, cardiovascular disease, neurodegenerative disease, and cancer. Understanding effects and mechanisms of ER stressassociated transcriptional reprogramming has high impact on many areas of molecular genetics and will be particularly informative to the development of pharmacologic avenues towards the prevention and treatment of modern common human diseases by targeting the UPR signaling. For these reasons, ER stress response and transcriptional reprogramming are a timely and necessary topic of discussion for Frontiers in Genetics. The important topics in this area include but not limited to: (1) ER-resident transcription factors and their involvements in ER stress response and cell physiology; (2) Physiologic roles and molecular mechanisms of ER stress-associated transcriptional regulation in lipid and glucose metabolism; (3) In vitro and in vivo models for ER stress-associated transcriptional reprogramming; (4) ER stress-associated transcriptional regulation in human disease; (5) Therapeutic potentials by targeting ER stress response pathways
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  • 13
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    ISBN: 9782889195312
    Sprache: Englisch
    Seiten: 1 Online-Ressource (126 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems
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  • 14
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195596
    Sprache: Englisch
    Seiten: 1 Online-Ressource (211 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Synaesthesia is a rare experience in which one property of a stimulus evokes a secondary experience that is not typically associated with the first (e.g. hearing words can evoke tastes). In recent years a number of studies have highlighted the authenticity of synaesthesia and attempted to use the experience to inform us about typical processes in perception and cognition. This Research Topic brings together research on synaesthesia and typical cross modal interactions to discuss the mechanisms of synaesthesia and what it can tell us about typical perceptual processes. Topics include, but are not limited to, the neurocognitive mechanisms that give rise to synaesthesia; the extent to which synaesthesia does / does not share commonalities with typical cross-modal correspondences; broader cognitive and perceptual consequences that are linked to synaesthesia; and perspectives on the origins / defining characteristics of synaesthesia
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  • 15
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    ISBN: 9782889196241
    Sprache: Englisch
    Seiten: 1 Online-Ressource (238 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The sense of agency is de ...
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  • 16
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194834
    Sprache: Englisch
    Seiten: 1 Online-Ressource (344 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Until about a decade ago, ...
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  • 17
    ISBN: 9782889195206
    Sprache: Englisch
    Seiten: 1 Online-Ressource (240 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Experts are persons who are very knowledgeable about or skillful in a particular area. The aim of this Research Topic is to advance knowledge in the understanding of the phenomenon of expertise by putting together different lines of research that directly or indirectly study expertise. Herbert Simon’s expertise studies initiated two lines of research. One is interested in elucidating the cognitive processes underlying expertise, and the other investigates how expertise develops. These lines of research started with studies comparing experts and novices in chess, and then they extended to numerous areas of expertise such as music, medical diagnosis, sports, arts and sciences. In the field of judgment and decision making researchers investigate the quality of judgments and decisions of experts in different professions (e.g., clinical psychologists, medical practitioners, judges, meteorologists, stock brokers). Those lines of research explicitly investigate the topic of expertise, but there are other research areas that make a substantial contribution to understanding expertise. Scholars in language acquisition and in face perception, for example, investigate cognitive processes and development of expertise in areas in which almost everyone becomes an expert. Furthermore, skill acquisition research informs in detail about short term cognitive changes that may be important to understand how expertise develops. We are interested in original research that advances knowledge in the understanding of decision making, cognitive processes and development of expertise in sports, intellectual games, arts, scientific disciplines and professions, as well as expertise in cognitive abilities such as perception, memory, attention, language and imagery. We are also interested in theoretical articles in any of these areas, articles that describe computational or mathematical models of expertise, and articles offering a framework that would guide expertise research. Articles that offer integrative approaches of some of the areas described above are strongly encouraged. The goal of this Research Topic is to produce a hallmark piece of work in the field of expertise, which complements and does not overlap with the “Neural implementations of expertise” Research Topic in Frontiers in Human Neuroscience
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  • 18
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194339
    Sprache: Englisch
    Seiten: 1 Online-Ressource (100 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend support to the idea that Aß is not causative but can be considered as an “innocent bystander” in AD. Although preclinical research generated impressive lines of evidence about the several intracellular mechanism(s) whose impairment leads to the onset and progression of AD, clinical research aimed at the development of new drugs capable of preventing or delaying the onset of neuronal damage in AD patients has produced limited results. The drugs currently available for the treatment of AD are acetylcholinesterase inhibitors (AChEI) and the NMDA glutamate receptor antagonist memantine. The AChEI increase acetylcholine levels in the synaptic cleft, which are reduced because of the progressive damage of cholinergic neurons in cognitive brain areas (e.g. amygdala, hippocampus, and frontal cortex), whereas memantine is used to prevent/reduce calcium-dependent excitotoxic neuronal cell death. Both classes of drugs have been shown to improve symptoms related to cognitive decline, but their effects are confined largely to patients with mild to moderate AD, in particular during the first year or so of treatment. An alternative to this symptomatic treatments involves the use of drugs that intervene in the pathogenesis of the disease. Recently, monoclonal antibodies against Aß were proposed as novel agents capable to remove Aß from the brain thus preventing neuronal damage. The research topic focuses on the preclinical and clinical evidence about the several factors that contribute to the pathogenesis of AD as well as the potential therapeutic role of new classes of drugs still under preclinical or clinical development
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  • 19
    ISBN: 9782889196081
    Sprache: Englisch
    Seiten: 1 Online-Ressource (273 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Python is rapidly becoming the de facto standard language for systems integration. Python has a large user and developer-base external to theneuroscience community, and a vast module library that facilitates rapid and maintainable development of complex and intricate systems. In this Research Topic, we highlight recent efforts to develop Python modules for the domain of neuroscience software and neuroinformatics: - simulators and simulator interfaces - data collection and analysis - sharing, re-use, storage and databasing of models and data - stimulus generation - parameter search and optimization - visualization - VLSI hardware interfacing. Moreover, we seek to provide a representative overview of existing mature Python modules for neuroscience and neuroinformatics, to demonstrate a critical mass and show that Python is an appropriate choice of interpreter interface for future neuroscience software development
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  • 20
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    ISBN: 9782889196470
    Sprache: Englisch
    Seiten: 1 Online-Ressource (141 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation
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  • 21
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194636
    Sprache: Englisch
    Seiten: 1 Online-Ressource (95 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Cardiovascular responses to physical and/ or mental stressors has been a topic of great interest for some time. For example, significant changes of cardiovascular control and reactivity have been highlighted as important mechanisms for the protective effect of exercise as a simple and effective, non medical therapy for many pathologies. However, despite the great number of studies performed to date (e.g. 〉54,000 entries in Pubmed for “cardiovascular stress”), important questions of the role stress has on cardiovascular function still remain. For instance, What factors account for the different cardiovascular responses between mental and physical stressors? How do these different components of the cardiovascular system interact during stress? Which cardiovascular responses to stress are the most important for identifying normal, depressed, and enhanced cardiovascular function? Can these stress-induced responses assist with patient diagnosis and prognosis? What impact does physical fitness have on the relationship between cardiovascular function and health? The current topic examined our current understanding of cardiovascular responses to stress and the significant role that physical fitness has on these responses for improved function and health. Manuscripts focusing on heart rate variability (HRV), heart rate recovery, and other novel cardiovascular assessments were especially encouraged
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  • 22
    ISBN: 9782889195701
    Sprache: Englisch
    Seiten: 1 Online-Ressource (264 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The Halophiles 2013 meeting is a multidisciplinary international congress, with a strong history of regular triennial meetings since 1978. Our mission is to bring researchers from a wide diversity of investigation interests (e.g., protein and species evolution; niche adaptation, ecology, taxonomy, genomics, metagenomics, horizontal gene transfer, gene regulation; DNA replication, repair and recombination; signal transduction; community assembly and species distribution; astrobiology; biotechnological applications; adaptation to radiation, desiccation, osmotic stress) into a single forum for the integration and synthesis of ideas and data from all three domains of life, and their viruses, yet from a single environment; salt concentrations greater than seawater. This cross-section of research informs our understanding of the microbiological world in many ways. The halophilic environment is extreme, especially above 10% NaCl, restricting life solely to microbes. The microorganisms that live there are adapted to extreme conditions, and are notable for their ability to survive high doses of radiation and desiccation. Therefore, the hypersaline environment is a model system (both the abiotic, and biologic factors) for insightful understanding regarding conditions and life in the absence of plant and animals (e.g., life on the early earth, and other solar system bodies like Mars and Europa). Lower salinity conditions (e.g., 6-10% NaCl) form luxuriant microbial mats considered modern analogues of fossilized stromatolites, which are enormous microbially produced structures fashioned during the Precambrian (and still seen today in places like Shark’s Bay, Australia). Hypersaline systems are island-like habitats spread patchily across the earth’s surface, and similar to the Galapagos Islands represent unique systems excellent for studying the evolutionary pressures that shape microbial community assembly, adaptation, and speciation. The unique adaptations to this extreme environment produce valuable proteins, enzymes and other molecules capable of remediating harsh human instigated environments, and are useful for the production of biofuels, vitamins, and retinal implants, for example. This research topic is intended to capture the breadth and depth of these topics
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  • 23
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194971
    Sprache: Englisch
    Seiten: 1 Online-Ressource (215 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: From simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signaling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with metabolic activities, sensing and chaperoning, distributing and storing, or excreting excess to prevent detrimental biochemical reactions. Since transition metal deficiency and overload both limit cell growth it is no surprise that the immune system evolved a dual strategy, of metal starvation or intoxication, to thwart microbial invasions. Like environmental metal availability determined biological use it also shaped host-microbe metal economy: Fe and Mn, available early in evolution and still required rather ubiquitously, are generally withheld by host in response to infection; Zn and Cu, which became bioavailable later, essentially to eukaryotic cells may be bombarded toward invaders. Successful microbial pathogens have evolved elaborate counter-measures to cope with host metal defenses. This research topic aims to review and discuss metal currencies in host-microbe interactions focusing on new findings about micro-organism pathogenesis determinants in the face of host innate strategies to interfere with microbial physiology
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  • 24
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196814
    Sprache: Englisch
    Seiten: 1 Online-Ressource (108 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Modern molecular -omics tools (metagenomics, metaproteomics etc.) have greatly contributed to the rapid advancement of our understanding of microbial diversity and function in the world’s oceans. These tools are now increasingly applied to host-associated environments to describe the symbiotic microbiome and obtain a holistic view of marine host-microbial interactions. Whilst all eukaryotic hosts are likely to benefit from their microbial associates, marine sessile eukaryotes, including macroalgae, seagrasses and various invertebrates (sponges, acidians, corals, hydroids etc), rely in particular on the function of their microbiome. For example, marine sessile eukaryotes are under constant grazing, colonization and fouling pressure from the millions of micro- and macroorganisms in the surrounding seawater. Host-associated microorganisms have been shown to produce secondary metabolites as defense molecules against unwanted colonization or pathogens, thus having an important function in host health and survival. Similarly microbial symbionts of sessile eukaryotes are often essential players in local nutrient cycling thus benefiting both the host and the surrounding ecosystem. Various research fields have contributed to generating knowledge of host-associated systems, including microbiology, biotechnology, molecular biology, ecology, evolution and biotechnology. Through a focus on model marine sessile host systems we believe that new insight into the interactions between host and microbial symbionts will be obtained and important areas of future research will be identified. This research topic includes original research, review and opinion articles that bring together the knowledge from different aspects of biology and highlight advances in our understanding of the diversity and function of the microbiomes on marine sessile hosts
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  • 25
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196913
    Sprache: Englisch
    Seiten: 1 Online-Ressource (284 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms
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  • 26
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196500
    Sprache: Englisch
    Seiten: 1 Online-Ressource (217 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Multi-item surveys are frequently used to study scores on latent factors, like human values, attitudes and behavior. Such studies often include a comparison, between specific groups of individuals, either at one or multiple points in time. If such latent factor means are to be meaningfully compared, the measurement structures including the latent factor and their survey items should be stable across groups and/or over time, that is ‘invariant’. Recent developments in statistics have provided new analytical tools for assessing measurement invariance (MI). The aim of this special issue is to provide a forum for a discussion of MI, covering some crucial ‘themes’: (1) ways to assess and deal with measurement non-invariance; (2) Bayesian and IRT methods employing the concept of approximate measurement invariance; and (3) new or adjusted approaches for testing MI to fit increasingly complex statistical models and specific characteristics of survey data. The special issue started with a kick-off meeting where all potential contributors shared ideas on potential papers. This expert workshop was organized at Utrecht University in The Netherlands and was funded by the Netherlands Organization for Scientific Research (NWO-VENI-451-11-008). After the kick-off meeting the authors submitted their papers, all of which were reviewed by experts in the field. The papers in the eBook are listed in alphabetical order, but in the editorial the papers are introduced thematically. Although it is impossible to cover all areas of relevant research in the field of MI, papers in this eBook provide insight on important aspects of measurement invariance. We hope that the discussions included in this special issue will stimulate further research on MI and facilitate further discussions to support the understanding of the role of MI in multi-item surveys
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  • 27
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194032
    Sprache: Englisch
    Seiten: 1 Online-Ressource (179 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The formation of the proper pattern of neuronal circuits during development is critical for the normal function of the vertebrate brain and for the survival of the organism. Circuit tracing studies spanning the past 100 years have revealed the beauty and exquisite intricacy of this pattern, which represents the most complex biological system known. In humans, aberrant circuit formation is a likely underlying cause of a wide variety of birth defects and neurological disorders, including autism, intellectual disability, and schizophrenia. Furthermore, future therapeutic approaches to restoring the function of damaged neural circuits will require a better understanding of the developmental constraints under which those circuits were originally assembled. For these reasons, elucidating the molecular mechanisms of neural circuit formation is a major goal of neurobiology today
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  • 28
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196616
    Sprache: Englisch
    Seiten: 1 Online-Ressource (97 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Oceans include the greate ...
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  • 29
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194872
    Sprache: Englisch
    Seiten: 1 Online-Ressource (188 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: While most natural languages rely on speech, humans can spontaneously generate comparable linguistic systems that utilize manual gestures. This collection of papers examines the interaction between natural language and its phonetic vessels - human speech or manual gestures. We seek to identify what linguistic aspects are invariant across signed and spoken languages, and determine how the choice of the phonetic vessel shapes language structure, its processing and its neural implementation. We welcome rigorous empirical studies from a wide variety of perspectives, ranging from behavioral studies to brain analyses, diverse ages (from infants to adults), and multiple languages - both conventional and emerging home signs and sign languages
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  • 30
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194995
    Sprache: Englisch
    Seiten: 1 Online-Ressource (280 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Macrophages have unique a ...
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  • 31
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196982
    Sprache: Englisch
    Seiten: 1 Online-Ressource (62 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology
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  • 32
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194421
    Sprache: Englisch
    Seiten: 1 Online-Ressource (150 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The cell wall is a complex structure mainly composed of cellulose microfibrils embedded in a cohesive hemicellulose and pectin matrix. Cell wall structural proteins, enzymes and their inhibitors are also essential components of plant cell walls. They are involved in the cross-link of cell wall polysaccharides, wall structure, and the perception and signaling of defense-related elicitors at the cell surface. In the outer part of the epidermal cells, the polysaccharides are coated by the cuticle, consisting of hydrophobic cutin, suberin and wax layers. Lignin, a macromolecule composed of highly cross-linked phenolic molecules, is a major component of the secondary cell wall. The cell wall is the first cell structure on which interactions between plants and a wide range of other organisms, including insects, nematodes, pathogenic or symbiotic micro-organisms take place. It not only represents a barrier that limits access to the cellular contents that provide a rich nutrient source for pathogens but serves as a source of elicitors of plant defense responses released upon partial enzymatic degradation of wall polysaccharides during infection. Modification of the plant cell wall can also occur at the level of plasmodesmata during virus infection as well as during abiotic stresses. The fine structure and composition of the plant cell wall as well as the regulation of its biosynthesis can thus strongly influence resistance and susceptibility to pathogens. This Research Topic provides novel insights and detailed overviews on the dynamics of the plant cell wall in plant defence, parasitism and symbiosis and describes experimental approaches to study plant cell wall modifications occurring during interaction of plants with different organisms
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  • 33
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196760
    Sprache: Englisch
    Seiten: 1 Online-Ressource (194 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease
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  • 34
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197101
    Sprache: Englisch
    Seiten: 1 Online-Ressource (96 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and ARBs on the progression of nephropathy, the emergence of new biomarkers such as Cystatin and the role of cytokines, inflammatory molecules and adhesion molecules. Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions. Presented in this e-book articles highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process
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  • 35
    ISBN: 9782889193783
    Sprache: Englisch
    Seiten: 1 Online-Ressource (189 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The study of plant-microbe associations by new techniques has significantly improved our understanding of the structure and specificity of the plant microbiome. Yet, microbiome function and the importance of the plant’s microbiome in the context of human and plant health are largely unexplored. Comparable with our human microbiome, millions of microbes inhabit plants, forming complex ecological communities that influence plant growth and health through its collective metabolic activities and host interactions. Viewing the microbiota from an ecological perspective can provide insight into how to promote plant health and stress tolerance of their hosts or how to adapt to a changing climate by targeting this microbial community. Moreover, the plant microbiome has a substantial impact on human health by influencing our gut microbiome by eating raw plants such as lettuce and herbs but also by influencing the microbiome of our environment through airflow. This research topic comprising reviews, original and opinion articles highlights the current knowledge regarding plant microbiomes, their specificity, diversity and function as well as all aspects studying the management of plant microbiomes to enhance plant growth, health quality and stress tolerance
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  • 36
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196968
    Sprache: Englisch
    Seiten: 1 Online-Ressource (132 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Our brain is endowed with ...
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  • 37
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193905
    Sprache: Englisch
    Seiten: 1 Online-Ressource (87 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing
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  • 38
    ISBN: 9782889194162
    Sprache: Englisch
    Seiten: 1 Online-Ressource (124 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: This Research Topic aims to showcase the state of the art in visual advertising research. Although visual processes are a central component of consumer behavior, they have been largely neglected in models explaining consumer perception of advertising. Rather than being the mere input into the cognitive or affective systems, the visual processes both voluntarily and involuntarily affect the amount and quality of information that is passed into further mental processing. Moreover, advertisements provide a well- designed, rich and stimulating environment to study visual processes in real-life conditions. Consumers encounter thousands of advertisement messages per day. Previous research on visual perception of advertising mostly considers print advertising. However, advertising messages increasingly appear in a variety of formats and in different media. Part of these messages are still conveyed through traditional media, such as newspapers, magazines, television, as well as outdoor and supermarket advertising. In addition, the amount and diversity of visual marketing stimuli is rapidly growing in terms of different advertising formats appearing in online and social media, smartphones and tablets. This challenges the marketing professionals and academics to better understand the impact of marketing on consumers. At the same time, the technical development of the research methods allows better opportunities to investigate advertising perception in different environments. Traditionally, papers investigating the psychological processes underlying advertising perception are published in journals widespread across different disciplines, such as marketing, applied psychology and human computer interaction journals. With this Research Topic, we aim to create a forum in which experts in different fields define the state of the art and future directions of the research on the visual aspects of marketing. We include reviews and original research papers involving both empirical and theoretical studies on visual perception of advertising across different media
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  • 39
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196357
    Sprache: Englisch
    Seiten: 1 Online-Ressource (69 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The ischemic penumbra was initially defined by Symon, Lassen and colleagues in the 1970s as an area of brain tissue with inadequate blood flow to maintain electric activity of neurons but adequate blood flow to preserve the function of the ion channels. This area of tissue, receiving enough blood to survive but not enough to function, often surrounds or abuts the irreversibly damaged core in ischemic stroke. It was shown that if blood flow could be restored to this area of marginal perfusion, the tissue could survive and function again, and growth of the core could be prevented. Based on seminal PET studies, penumbra or "penumbral tissue" eventually took on a subtly different meaning - the area of brain that is destined to progress to infarct unless blood flow is restored within a particular time window. The penumbra thus became the target for all acute stroke interventions - to preserve viability of the tissue and restore function. New imaging techniques, including diffusion and perfusion MRI and CT perfusion, were developed to rapidly identify individuals with penumbra, who were thought to be the best candidates for aggressive interventions to restore blood flow, particularly beyond the licensed time-window for IV thrombolysis. However, most clinical trials have failed to establish the usefulness of identifying candidates for treatment in this way using pre-specified protocols and primary endpoints. These trials have used different and sometimes unvalidated thresholds of hypoperfusion as well as irreversible infarct and various definitions of significant penumbra (or mismatch between irreversible infarct and hypoperfused, but salvageable tissue), and reanalysis of their data using more refined image processing showed post-hoc positivity. They have also evaluated outcome in a variety of ways, with few studies measuring the direct effect of restoring blood flow on the function of the penumbral tissue. Therefore, important remaining questions include how to define, characterize, and image the penumbra in acute stroke to achieve the greatest reliability and validity for what we want to measure, and whether this concept, so defined, provides an optimal target for stroke therapy using state-of-the-art trial design
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  • 40
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194674
    Sprache: Englisch
    Seiten: 1 Online-Ressource (122 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Coordinated cell interact ...
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  • 41
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195640
    Sprache: Englisch
    Seiten: 1 Online-Ressource (158 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Mammalian pregnancy repre ...
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  • 42
    ISBN: 9782889195602
    Sprache: Englisch
    Seiten: 1 Online-Ressource (202 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Current theories of visual change detection emphasize the importance of conscious attention to detect unexpected changes in the visual environment. However, an increasing body of studies shows that the human brain is capable of detecting even small visual changes, especially if such changes violate non-conscious probabilistic expectations based on repeating experiences. In other words, our brain automatically represents statistical regularities of our visual environmental. Since the discovery of the auditory mismatch negativity (MMN) event-related potential (ERP) component, the majority of research in the field has focused on auditory deviance detection. Such automatic change detection mechanisms operate in the visual modality too, as indicated by the visual mismatch negativity (vMMN) brain potential to rare changes. VMMN is typically elicited by stimuli with infrequent (deviant) features embedded in a stream of frequent (standard) stimuli, outside the focus of attention. In this research topic we aim to present vMMN as a prediction error signal. Predictive coding theories account for phenomena such as mismatch negativity and repetition suppression, and place them in a broader context of a general theory of cortical responses. A wide range of vMMN studies has been presented in this Research Topic. Twelve articles address roughly four general sub-themes including attention, language, face processing, and psychiatric disorders. Additionally, four articles focused on particular subjects such as the oblique effect, object formation, and development and time-frequency analysis of vMMN. Furthermore, a review paper presented vMMN in a hierarchical predictive coding framework. Each paper in this Research Topic is a valuable contribution to the field of automatic visual change detection and deepens our understanding of the short term plasticity underlying predictive processes of visual perceptual learning
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  • 43
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194315
    Sprache: Englisch
    Seiten: 1 Online-Ressource (158 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Organisms are equipped with value systems that signal the salience of environmental cues to their nervous system, causing a change in the nervous system that results in modification of their behavior. These systems are necessary for an organism to adapt its behavior when an important environmental event occurs. A value system constitutes a basic assumption of what is good and bad for an agent. These value systems have been effectively used in robotic systems to shape behavior. For example, many robots have used models of the dopaminergic system to reinforce behavior that leads to rewards. Other modulatory systems that shape behavior are acetylcholine’s effect on attention, norepinephrine’s effect on vigilance, and serotonin’s effect on impulsiveness, mood, and risk. Moreover, hormonal systems such as oxytocin and its effect on trust constitute as a value system. This book presents current research involving neurobiologically inspired robots whose behavior is: 1) Shaped by value and reward learning, 2) adapted through interaction with the environment, and 3) shaped by extracting value from the environment
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  • 44
    ISBN: 9782889196135
    Sprache: Englisch
    Seiten: 1 Online-Ressource (314 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: What can we learn from sp ...
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  • 45
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195671
    Sprache: Englisch
    Seiten: 1 Online-Ressource (62 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field
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  • 46
    ISBN: 9782889194735
    Sprache: Englisch
    Seiten: 1 Online-Ressource (132 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: From the moment of birth, humans and animals are immersed in time: all experiences and actions evolve in time and are dynamically structured. The perception of time is thus a capacity indispensable for the control of perception, cognition and action. The last 10 years have witnessed a remarkable resurgence of interest in timing and time perception, with a continuously increasing number of researchers exploring these innate abilities. However, existing robotic systems largely neglect the key role of time in cognition and action. This is a major barrier for accomplishing the long-term goal of symbiotic human-robot interaction. The critical question is: how is time instantiated in a biological system and how can it be implemented in an artificial system? Recent years have for example seen an increasing focus on the relationship between affective states and the experience of time. The influence of affective states on subjective time seems to depend on the embodiment of emotions: intertwined affective and interoceptive states may create our subjective experience of time. Since robotic systems are in essence embodied information-processing systems that interact with the real world, we hope to inspire a reciprocal exchange of ideas between the field of Robotics and the Cognitive Neurosciences. In this research topic, we call researchers from different disciplines (Robotics, Neurosciences, and Psychology) to present their empirical work, their models or reviews on the question of how time judgments are instantiated in biological and artificial systems. Of particular interest are papers on time perception in humans and animals, with a focused interest on embodied time perception, i.e. the influence of affective and body states on time judgments. Moreover, the present Research Topic seeks to gather papers discussing the key role of time on different aspects of robotic cognition as well as modeling approaches. We are interested in paving the way for a new generation of intelligent computational systems that incorporate the sense of time in their processing loop and thus accomplish more efficient and more advanced cognitive capacities
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  • 47
    ISBN: 9782889193912
    Sprache: Englisch
    Seiten: 1 Online-Ressource (178 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, management and outcome prediction of TBI are antiquated, unidimensional and inadequate to capture the interindividual pathophysiological heterogeneity. Recent advances in proteomics and biomarker development provide unparalleled opportunities for unraveling substantial injury-specific and patient-specific variability and refining disease characterization. The identification of novel, sensitive, objective tools, referred to as biomarkers, can revolutionize pathophysiological insights, enable targeted therapies and personalized approaches to clinical management. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. In this Research Topic, we present novel approaches that provide an infrastructure for discovery and validation of new biomarkers of acute brain injury. These techniques include refined mass spectrometry technology and high throughput immunoblot techniques. Output from these approaches can identify potential candidate biomarkers employing systems biology and data mining methods. Finally, suggestions are provided for the way forward, with an emphasis on need for a multidimensional approach that integrate a panel of pathobiologically diverse biomarkers with clinical variables and imaging-based assessments to improve diagnosis and classification of TBI and to develop best clinical practice guidelines
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  • 48
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195299
    Sprache: Englisch
    Seiten: 1 Online-Ressource (413 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: An important amount of research effort in psychology and neuroscience over the past decades has focused on the problem of social cognition. This problem is understood as how we figure out other minds, relying only on indirect manifestations of other people's intentional states, which are assumed to be hidden, private and internal. Research on this question has mostly investigated how individual cognitive mechanisms achieve this task. A shift in the internalist assumptions regarding intentional states has expanded the research focus with hypotheses that explore the role of interactive phenomena and interpersonal histories and their implications for understanding individual cognitive processes. This interactive expansion of the conceptual and methodological toolkit for investigating social cognition, we now propose, can be followed by an expansion into wider and deeply-related research questions, beyond (but including) that of social cognition narrowly construed. Our social lives are populated by different kinds of cognitive and affective phenomena that are related to but not exhausted by the question of how we figure out other minds. These phenomena include acting and perceiving together, verbal and non-verbal engagement, experiences of (dis-)connection, management of relations in a group, joint meaning-making, intimacy, trust, conflict, negotiation, asymmetric relations, material mediation of social interaction, collective action, contextual engagement with socio-cultural norms, structures and roles, etc. These phenomena are often characterized by a strong participation by the cognitive agent in contrast with the spectatorial stance typical of social cognition research. We use the broader notion of embodied intersubjectivity to refer to this wider set of phenomena. This Research Topic aims to investigate relations between these different issues, to help lay strong foundations for a science of intersubjectivity – the social mind writ large. To contribute to this goal, we encouraged contributions in psychology, neuroscience, psychopathology, philosophy, and cognitive science that address this wider scope of intersubjectivity by extending the range of explanatory factors from purely individual to interactive, from observational to participatory
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  • 49
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196647
    Sprache: Englisch
    Seiten: 1 Online-Ressource (104 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: An exciting new line of research that investigates the impact of one’s own hands on visual processing has flourished in the past several years. Specifically, several studies have demonstrated that objects near the hands receive prioritized attention, enhanced perceptual sensitivity, altered figure-ground assignment, prolonged and detail-oriented processing, and improved visual working memory. Taken together, these results demonstrate that the visual system reveals a new pattern of processing when one's hands are in proximity of viewed objects. Therefore, the vast majority of studies on visual processing, in which one's hands are kept away from the stimuli, may constitute but one side of a more complex story of the inner workings of the visual system. With several consistent behavioral demonstrations of hand-altered vision now in the literature, the present challenge facing this growing field, and the aim of this Research Topic, is four-pronged: 1) Isolate and elucidate the underlying cognitive and neural mechanisms of hand-altered vision; 2) Map the parameters and conditions of hand-nearness that permit/prevent the onset or maintenance of hand-altered vision; 3) Determine the consequences of hand-altered vision for higher-level cognition and assess its applied potential (e.g., as a neuropsychological intervention); and, 4) Present a cohesive and predictive theoretical account of hand-altered vision. We welcome submissions that fit into any one (or a combination) of the above domains. For behavioral research, we particularly encourage submissions that are relevant to the advancement of our understanding of the neural mechanisms of hand-altered vision (e.g., demonstrations that might corroborate or disconfirm proposed neural systems)
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  • 50
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195190
    Sprache: Englisch
    Seiten: 1 Online-Ressource (126 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The advent of educational neuroscience, a transdisciplinary exercise emerging from cognitive neuroscience and educational psychology, is the examination of physiological processes that undermine, support, and enhance the capacities to learn and create. The physiological underpinnings of learning and creativity each impact human ability and performance and mediate the processes of becoming educated, expert, and valued. Evidence of learning provides support to an ongoing canon, process, system, field or domain, while evidence of creativity results in an elaboration or departure from an ongoing canon, process, system, field, or domain. Educational neuroscience extends a challenge to scholars from multiple contexts to engage in the characterization and exploration of human ability and performance in these realms. The role of context, both environmental and interoceptive, is an integral part of efforts in educational neuroscience and in theories of constructivist learning to contribute ecologically valid insight to the pragmatic processes of learning and creativity. Examination at this level of specificity is vital to our ability to educate and support human potential in the 21st century. This Research Topic examines the neural basis of cognitive states and processes that influence knowledge and skill acquisition tied to the demonstration of human ability and performance across individual differences and in multiple contexts including STEM learning and the arts
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  • 51
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194988
    Sprache: Englisch
    Seiten: 1 Online-Ressource (94 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties
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  • 52
    ISBN: 9782889193448
    Sprache: Englisch
    Seiten: 1 Online-Ressource (110 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The endoplasmic reticulum (ER) is a manufacturing unit in eukaryotic cells required for the synthesis of proteins, lipids, metabolites and hormones. Besides supporting cellular signalling networks by its anabolic function, the ER on its own or in communication with other organelles directly initiates signalling processes of physiological significance. Based on the intimate and immediate involvement in stress signalling the ER is considered as sensory organelle on which cells strongly rely to effectively translate environmental cues into adaptive stress responses. The transcellular distribution of the ER providing comprehensive cell-to-cell connections in multicellular organisms probably allows a concerted action of cell alliances and tissue areas towards environmental constraints. At the cellular level, stress adaptation correlates with the capability of the ER machinery to synthesise proteins participating in stress signalling as well as in the activation of ER membrane localised proteins to start cell-protective signalling processes. Importantly, depending on the stress insult, the ER either supports protective strategies or initiates cell death programmes. Recent, genetic, molecular and cell biological studies have drawn an initial picture of underlying signalling events activated by ER membrane localised proteins. In this Research Topic, we provided a platform for articles describing research on ER morphology and metabolism with a focus on stress translation. The Research Topic is sub-divided into the following sections: 1. ER in stress signalling and adaptation 2. ER structure and biosynthetic functions 3. Regulation of protein processing 4. Regulation of programmed cell death
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  • 53
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194926
    Sprache: Englisch
    Seiten: 1 Online-Ressource (101 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Microglial cells play a v ...
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  • 54
    ISBN: 9782889196852
    Sprache: Englisch
    Seiten: 1 Online-Ressource (123 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: One of the key features o ...
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  • 55
    ISBN: 9782889195688
    Sprache: Englisch
    Seiten: 1 Online-Ressource (95 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In September 2011, scientists announced new experimental findings that would not only threaten the conduct and publication of influenza research, but would have significant policy and intelligence implications. The findings presented a modified variant of the H5N1 avian influenza virus (hereafter referred to as the H5N1 virus) that was transmissible via aerosol between ferrets. These results suggested a worrisome possibility: the existence of a new airborne and highly lethal H5N1 virus that could cause a deadly global pandemic. In response, a series of international discussions on the nature of dual-use life science arose. These discussions addressed the complex social, technical, political, security, and ethical issues related to dual-use research. This Research Topic will be devoted to contributions that explore this matrix of issues from a variety of case study and international perspectives
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  • 56
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197415
    Sprache: Englisch
    Seiten: 1 Online-Ressource (82 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis
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  • 57
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193950
    Sprache: Englisch
    Seiten: 1 Online-Ressource (120 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the past 20 years protein engineering has been used for the production of proteins mostly for biological applications. The incorporation of artificial amino acids and chemical handles into proteins had made possible the design and production of protein-based materials like hybrid inorganic-organic materials, smart/ responsive materials, monodisperse polymers, and nanoscale assemblies. In the current topic, we cover current uses and envision future applications of materials generated using protein engineering and biosynthesis techniques
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  • 58
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196104
    Sprache: Englisch
    Seiten: 1 Online-Ressource (204 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Post-translational modifi ...
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  • 59
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195503
    Sprache: Englisch
    Seiten: 1 Online-Ressource (134 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release
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  • 60
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195961
    Sprache: Englisch
    Seiten: 1 Online-Ressource (53 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: There is an extensive literature conducted from a range of theoretical perspectives and methodologies on the role of groups and student learning in higher education. However here the concept of the ‘group’ is heavily contested at a theoretical level but within higher education practice, characterizing the group has tended to be clear cut. Groups of students are often formed within the parameters of specific educational programs to address explicitly defined learning objectives. These groups are often small scale and achieve tasks through cooperative or collaborative learning. Cooperative learning involves students dividing roles and responsibilities between group members, so learning becomes an independent process and outcome. On the other hand, collaborative learning involves students working together by developing shared meanings and knowledge to solve a task or problem. From this perspective, learning is conceptualized as both a social process and individual outcome. That is, collaborative learning may facilitate individual student conceptual understanding and hence lead to higher academic achievement. The empirical evidence is encouraging as has been shown that students working collaboratively tend to achieve higher grades than students working independently. However the above perspectives on student engagement assume that groups are formed within the confines of formal learning environments (e.g. lecture theaters), involve students on the same degree program, have the explicit function of achieving a learning task and disband once this has been achieved. However, students may also use existing social networks such as friendship groups as a mechanism for learning, which may occur outside of formal learning environments. There is an extensive literature on the role and benefits of friendship groups on student learning within primary and secondary education but there is a distinct lack of research within higher education. This ebook is innovative and ambitious and will highlight and consolidate, the current understanding of the role that student based engagement behaviors may serve in effective pedagogy. A unique aspect of this research topic will be the fact that scholars will also be welcome to submit articles that describe the efficacy of the full range of approaches that have been employed to facilitate student engagement across the sector
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  • 61
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194070
    Sprache: Englisch
    Seiten: 1 Online-Ressource (95 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Oxytocin (OT) and arginin ...
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  • 62
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193165
    Sprache: Englisch
    Seiten: 1 Online-Ressource (91 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Cigarette smoke exposure is the key initiator of chronic inflammation, alveolar destruction, and the loss of alveolar blood vessels that lead to the development of chronic obstructive pulmonary disease (COPD) which is comprised of emphysema and chronic bronchitis. Exposure to secondhand smoke (SHS) is the major risk factor for non-smokers to develop emphysema. While the first-hand smoke is directly inhaled by smokers, passive smoking occurs when non-smokers are involuntary exposed to environmental tobacco smoke also known as second hand smoke (SHS). SHS is a mixture of 2 forms of smoke that come from burning tobacco: side stream smoke (smoke that comes from the end of a lit cigarette, pipe, or cigar) and mainstream smoke (smoke that is exhaled by a smoker). These two types of smoke have basically the same composition, however in SHS many toxic components are more concentrated than in first-hand smoke, therefore more hazardous for people’s health. Several pathological events have been implicated in the development of SHS-induced COPD, but many aspects of this pathology remain poorly understood halting the development of new advanced treatments for this detrimental disease. In this respect we have welcomed leading investigators in the field to share their research findings and provide their thoughts regarding the mechanisms of the SHS exposure-induced immune responses and inflammatory mechanisms of lung destruction in SHS-induced COPD and related comorbidities
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  • 63
    ISBN: 9782889194711
    Sprache: Englisch
    Seiten: 1 Online-Ressource (78 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Physical activity and exercise were receiving a great attention as a strategy of prevention and treatment of affective and some anxiety disorders. Many studies have showed the efficacy of exercise in major depression and at depressed episode of bipolar patients, as well as, some authors shows the benefits of exercise in some anxiety disorders like Generalized Anxiety Disorder and Panic. Despite their efficacy, little is known concerning the main mechanisms related to the antidepressant and anxiolytic effects of exercise. Several studies in an animal model using Neurotrophic Factors, Oxidative Stress, Immunologic response and other biological markers reveal promising results. However, few studies were conducted in clinical samples. Additional to the antidepressant and anxiolytic effects, exercise appears improve QoL in major depressed, bipolar and anxiety patients. Theoretically, this increase may be associated with cognitive improvements, improvements at sleep quality, physical functioning, as well as other psychological issues as self-esteem, self-concept, and general well-being. The propose of this topic is to address the novelty and most recent research, related to antidepressant and anxiolytic effects of physical activity and exercise in patients with affective and anxiety disorders, as well as the issues associated with QoL improvement.The topic is looking for: – Clinical trials using exercise and physical activity as a treatment affective and anxiety disorders. – Studies investigating the optimal prescription factors (dose, volume, intensity, setting, frequency) associated with antidepressant and anxiolytic effects of physical activity and exercise for affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning the mechanisms of antidepressant and anxiolytic effects of physical activity and exercise in affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning other benefits of physical activity and exercise like : cognition, weight gain prevention and QoL in affective and anxiety disorder patients. – Translational research. – Studies of cost-efficacy analysis
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  • 64
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194414
    Sprache: Englisch
    Seiten: 1 Online-Ressource (115 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Reversible ubiquitylation plays an important regulatory role in almost all aspects of cellular and organismal processes in plants. Its pervasive regulatory role in plant biology is primarily due to the involvement of a large set of ubiquitin system constituents (encoded by approximately 6% Arabidopsis genome), the huge number of important cellular proteins targeted as substrates, and various drastic effects on the modified proteins. The major components of the ubiquitin system include a large set of enzymes and proteins involved in ubiquitin conjugation (E1s, E2s, and E3s) and deconjugation (deubiquitinases of different classes) and post ubiquitin conjugation components such as ubiquitin receptors, endocytic machineries, and 26S proteasome. The established substrates include transcriptional activators and repressors, signaling components, key metabolic enzymes, and critical mechanistic components of major cellular processes and regulatory mechanisms. Post-translational modification of proteins by reversible ubiquitylation could drastically affects the modified proteins by proteolytic processing and turnover, altering catalytic activity, subcellular targeting, and protein-protein interaction. Continued efforts are being carried out to identify novel substrates critical for various cellular and organismal processes, to determine effects of reversible ubiquitylation on the modified substrates, to determine signaling determinants triggering reversible ubiquitylation of specific substrates, to illustrate individual components of the ubiquitin system for their in vivo functions and involved mechanistic roles, and to determine mechanistic roles of modification acting on critical components of major cellular processes and regulatory mechanisms. The aim of this special topic is to serve as a platform to report most recent advances on those above listed current research endeavors. We welcome article types including original research, review, mini review, method, and perspective/opinion/hypothesis
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  • 65
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194681
    Sprache: Englisch
    Seiten: 1 Online-Ressource (115 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Pancreatic Cancer has bee ...
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  • 66
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194407
    Sprache: Englisch
    Seiten: 1 Online-Ressource (115 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction
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  • 67
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196906
    Sprache: Englisch
    Seiten: 1 Online-Ressource (104 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function
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  • 68
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196227
    Sprache: Englisch
    Seiten: 1 Online-Ressource (80 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism
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  • 69
    ISBN: 9782889196098
    Sprache: Englisch
    Seiten: 1 Online-Ressource (81 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Intracellular pathogens, such as bacteria and parasites, have evolved specialized mechanisms to survive and replicate in their host, leading to disorders and diseases. The principle of these mechanisms is to reprogram the microbicidal cell function in order to disable the host cells defence that aims to control and eliminate foreign invaders. Devoid of their defence, cells become permissive to pathogens invasion. The aim of this Research Topic is to highlight and cover recent understanding of mechanisms and molecules used by pathogens to interfere with the microbicidal function of cells. This Research Topic will focus on the reprogramming of the cellular dynamics, the immune response, the phagolysosome biogenesis and the signal transduction pathways bypathogens. Special attention will be made on non-proteic virulence factors, however this Research Topic is not restricted to non-proteic virulence factors
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  • 70
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    ISBN: 9782889196517
    Sprache: Englisch
    Seiten: 1 Online-Ressource (134 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market. However, endogenous GPCRs are most often difficult to study because of a lack of tools to target them specifically and single out their response to physiological or drug-elicited stimulations. Hence, studies mostly focused on recombinant receptors expressed in a variety of cellular models that do not always closely reflect the receptor natural environment and often deal with levels of expression exceeding by far physiological ranges. Recent technological developments combining for example genetically modified animals and advanced imaging approaches have improved our ability to visualize endogenous GPCRs. To date, trailing receptor activation, subsequent intracellular redistribution, changes in signaling cascade up to integrated response to a drug-elicited stimulation is at hand though the impact of a physiological challenge on receptor dynamics remains a major issue. Data however suggest that the receptor may embrace a different fate depending on the type of stimulation in particular if sustained or repeated. This suggests that current drugs may only partially mimic the genuine response of the receptor and may explain, at least in part, their secondary effects. Commonalities and specificities between physiological and drug-induced activation can thus represent valuable guidelines for the design of future drugs
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  • 71
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    ISBN: 9782889194124
    Sprache: Englisch
    Seiten: 1 Online-Ressource (174 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Nitrogen is an essential element in biological systems, and one that often limits production in both aquatic and terrestrial systems. Due to its requirement in biological macromolecules, its acquisition and cycling have the potential to structure microbial communities, as well as to control productivity on the ecosystem scale. In addition, its versatile redox chemistry is the basis of complex biogeochemical transformations that control the inventory of fixed nitrogen, both in local environments and over geological time. Although many of the pathways in the microbial nitrogen cycle were described more than a century ago, additional fundamental pathways have been discovered only recently. These findings imply that we still have much to learn about the microbial nitrogen cycle, the organisms responsible for it, and their interactions in natural and human environments. Progress in nitrogen cycle research has been facilitated by recent rapid technological advances, especially in genomics and isotopic approaches. In this Research Topic, we reviewed the leading edge of nitrogen cycle research based on these approaches, as well as by exploring microbial processes in modern ecosystems
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  • 72
    ISBN: 9782889196586
    Sprache: Englisch
    Seiten: 1 Online-Ressource (209 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Research on the human bra ...
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  • 73
    ISBN: 9782889195459
    Sprache: Englisch
    Seiten: 1 Online-Ressource (99 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: This topic aims to pool the most recent advances in the phenomenology and pathophysiology of levodopa-induced dyskinesias. The papers in this eBook have strongly contributed to reduce the gaps in our knowledge of LIDs pathogenesis
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  • 74
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196272
    Sprache: Englisch
    Seiten: 1 Online-Ressource (125 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Interaction between language and cognition remains an unsolved scientific problem. What are the differences in neural mechanisms of language and cognition? Why do children acquire language by the age of six, while taking a lifetime to acquire cognition? What is the role of language and cognition in thinking? Is abstract cognition possible without language? Is language just a communication device, or is it fundamental in developing thoughts? Why are there no animals with human thinking but without human language? Combinations even among 100 words and 100 objects (multiple words can represent multiple objects) exceed the number of all the particles in the Universe, and it seems that no amount of experience would suffice to learn these associations. How does human brain overcome this difficulty?
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  • 75
    ISBN: 9782889194117
    Sprache: Englisch
    Seiten: 1 Online-Ressource (314 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Left-right asymmetries of structure and function are a common organization principle in the brains of humans and non-human vertebrates alike. While there are inherently asymmetric systems such as the human language system or the song system of songbirds, the impact of structural or functional asymmetries on perception, cognition and behavior is not necessarily limited to these systems. For example, performance in experimental paradigms that assess executive functions such as inhibition, planning or action monitoring is influenced by information processing in the bottom-up channel. Depending on the type of stimuli used, one hemisphere can be more efficient in processing than the other and these functional cerebral asymmetries have been shown to modulate the efficacy of executive functions via the bottom-up channel. We only begin to understand the complex neuronal mechanisms underlying this interaction between hemispheric asymmetries and cognitive systems. Therefore, it is the aim of this Research Topics to further elucidate how structural or functional hemispheric asymmetries modulate perception, cognition and behavior in the broadest sense
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  • 76
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195763
    Sprache: Englisch
    Seiten: 1 Online-Ressource (116 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The oral cavity harbors a ...
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  • 77
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193189
    Sprache: Englisch
    Seiten: 1 Online-Ressource (127 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The cyanobacteria inhabit every illuminated environment on Earth, from polar lakes to desert crusts and through their phototrophic metabolism play essential roles in global geochemical cycles. With the discovery of marine Synechococcus and Prochlorococcus almost 30 years ago, cyanobacteria have now earned their place as dominant primary producers contributing over 25 percent of global photosynthesis. Their global abundance is now explained from the coexistence of ecotypes that occupy different niches along spatial and temporal gradients. New ecotypes of Synechococcus have been identified as abundant components of microbial communities in freshwater environments and marginal seas. Extensive comparative genomics of marine and freshwater picocyanobacteria have begun to unmask adaptations to light and nutrient (N, P, Fe) limitation that these diverse environments present. Novel types of cyanobacterial diazotrophy input new N and structure microbial communities in the open sea. Current challenges include the understanding of the interactions between marine cyanobacteria and other microbes in their immediate community. In contrast, mesotrophic and eutrophic environments such as the Laurentian Great Lakes have been increasingly affected by nuisance and toxic cyanobacterial blooms that have yielded severe declines in water quality. Factors promoting bloom formation and the functional roles of toxins are important issues being addressed today
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  • 78
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197408
    Sprache: Englisch
    Seiten: 1 Online-Ressource (111 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Are platelets cells? (Not ...
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  • 79
    ISBN: 9782889196937
    Sprache: Englisch
    Seiten: 1 Online-Ressource (109 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Silicon photonics technology, which has the DNA of silicon electronics technology, promises to provide a compact photonic integration platform with high integration density, mass-producibility, and excellent cost performance. This technology has been used to develop and to integrate various photonic functions on silicon substrate. Moreover, photonics-electronics convergence based on silicon substrate is now being pursued. Thanks to these features, silicon photonics will have the potential to be a superior technology used in the construction of energy-efficient cost-effective apparatuses for various applications, such as communications, information processing, and sensing. Considering the material characteristics of silicon and difficulties in microfabrication technology, however, silicon by itself is not necessarily an ideal material. For example, silicon is not suitable for light emitting devices because it is an indirect transition material. The resolution and dynamic range of silicon-based interference devices, such as wavelength filters, are significantly limited by fabrication errors in microfabrication processes. For further performance improvement, therefore, various assisting materials, such as indium-phosphide, silicon-nitride, germanium-tin, are now being imported into silicon photonics by using various heterogeneous integration technologies, such as low-temperature film deposition and wafer/die bonding. These assisting materials and heterogeneous integration technologies would also expand the application field of silicon photonics technology. Fortunately, silicon photonics technology has superior flexibility and robustness for heterogeneous integration. Moreover, along with photonic functions, silicon photonics technology has an ability of integration of electronic functions. In other words, we are on the verge of obtaining an ultimate technology that can integrate all photonic and electronic functions on a single Si chip. This e-Book aims at covering recent developments of the silicon photonic platform and novel functionalities with heterogeneous material integrations on this platform
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  • 80
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195626
    Sprache: Englisch
    Seiten: 1 Online-Ressource (80 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Frontiers in Psychology is introducing a new research topic, Pedagogical Psychology: Beyond the 21st Century, which will be released as an online journal issue in summer 2014. The purpose of Beyond the 21st Century will be to publish goal- oriented articles leading to improvement of teaching and learning at all levels of psychology education. Until perhaps 20 years ago, educational approaches to teaching were largely informed by a “Stand and Deliver” pedagogical attitude. The psychology of this approach has often invested unrealistic and unrealizable responsibilities in both teachers and students. With the emergence of electronic data sharing (e.g., the Internet) and global cooperation/competition, newer approaches to teaching have begun to supplement and sometimes replace the older model of teaching. These newer approaches have simultaneously taken advantage of technological advances, global changes, and an evolving understanding of successful student-mentor relationships. As the pedagogical models driven by these changes evolve into the 22nd century and beyond, what seems groundbreaking today will, in hindsight, be seen as hidebound. Thus, the major goal of Beyond the 21st Century will be to publish manuscripts which imaginatively, but realistically anticipate future trends in teaching undergraduate psychology
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  • 81
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    ISBN: 9782889197347
    Sprache: Englisch
    Seiten: 1 Online-Ressource (80 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases
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  • 82
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196128
    Sprache: Englisch
    Seiten: 1 Online-Ressource (117 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Cereal crops such as maiz ...
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  • 83
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193400
    Sprache: Englisch
    Seiten: 1 Online-Ressource (87 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response against self antigens. Many investigators have focused on the role type I interferons play in autoimmune disease. This fascinating and rapidly growing body of literature encompasses many different autoimmune diseases, including systemic lupus erythematosus, type I diabetes, multiple sclerosis, and others. In this Research Topic, we provide a comprehensive overview of the various roles type I interferons play in autoimmune diseases, with a focus on human immunology
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  • 84
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194483
    Sprache: Englisch
    Seiten: 1 Online-Ressource (94 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Viruses infect numerous microorganisms including, predominantly, Bacteria (bacteriophages or phages) but also Archaea, Protists, and Fungi. They are the most abundant and ubiquitous biological entities on Earth and are important drivers of ecosystem functioning. Little is known, however, about the vast majority of these viruses of microorganisms, or VoMs. Modern techniques such as metagenomics have enabled the discovery and description of more presumptive VoMs than ever before, but also have exposed gaps in our understanding of VoM ecology. Exploring the ecology of these viruses – which is how they interact with host organisms, the abiotic environment, larger organisms, and even other viruses across a variety of environments and conditions – is the next frontier. Integration of a growing molecular understanding of VoMs with ecological studies will expand our knowledge of ecosystem dynamics. Ecology can be studied at multiple levels including individual organisms, populations, communities, whole ecosystems, and the entire biosphere. Ecology additionally can consider normal, equilibrium conditions or instead perturbations. Perturbations are of particular interest because measuring the effect of disturbances on VoM-associated communities provides important windows into how VoMs contribute to ecosystem dynamics. These disturbances in turn can be studied through in vitro, in vivo, and in situ experimentation, measuring responses by VoM-associated communities to changes in nutrient availability, stress, physical disruption, seasonality, etc., and could apply to studies at all ecological levels. These are considered here across diverse systems and environments
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  • 85
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195534
    Sprache: Englisch
    Seiten: 1 Online-Ressource (87 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Though traditionally designed for entertainment, video games are being used more and more by psychologists to understand topics such as skill acquisition, cognitive capacity and plasticity, aging, individual differences, and development. The appeal of using video games over simpler laboratory paradigms partly comes from their ability to present rich and complex cognitive challenges more representative of the demands of the complex everyday tasks we perform outside of the laboratory. However, this complexity also presents a host of methodological and analytic challenges. This Research Topic brings together research using games to explore cognitive processes, with a special focus on the challenges of this approach. Challenges are in terms of design, implementation, or data analysis
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  • 86
    ISBN: 9782889194452
    Sprache: Englisch
    Seiten: 1 Online-Ressource (160 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system
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  • 87
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    ISBN: 9782889196722
    Sprache: Englisch
    Seiten: 1 Online-Ressource (86 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Testicular cancer (TC) is ...
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  • 88
    ISBN: 9782889195169
    Sprache: Englisch
    Seiten: 1 Online-Ressource (136 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Prosocial behaviors such ...
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  • 89
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194902
    Sprache: Englisch
    Seiten: 1 Online-Ressource (110 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The vision of this Fronti ...
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  • 90
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197330
    Sprache: Englisch
    Seiten: 1 Online-Ressource (115 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses
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  • 91
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197125
    Sprache: Englisch
    Seiten: 1 Online-Ressource (98 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, the most famous tumor suppressor. The p53 mutations either results in loss of function, or acting as dominant negative for wild-type protein, or ‘gain of function’ specifically promoting cancer survival. The gain of function is achieved by shifting p53 binding partner proteins, or changed genomic binding landscape leading to a cancer-promoting transcriptome. Another example of genetic change of TF causing malignancy is the AML-ETO fusion protein in the human t(8;21)-leukemia. The fusion protein is an active TF, and more interestingly, new studies link the disease causing role of AML-ETO to the unique transcriptome in the hematopoietic stem cells. Nuclear receptors (NR) are a group of ligand-dependent TFs governing the expression of genes involved in a broad range of reproductive, developmental and metabolic programs. Genetic changes and epigenetic modifications of NRs lead to cancers and metabolic diseases. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) are well studied NRs in prostate, breast and endometrial cancers. The development in sequencing technology and computational genomics enable us to investigate the transcription programs of these master TFs in an unprecedented level. This Research Topic aims to present the most up-to-date progress in the field of transcription regulation in cancers and metabolic diseases
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  • 92
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196388
    Sprache: Englisch
    Seiten: 1 Online-Ressource (102 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on structural and computational approaches to understanding carbohydrate recognition by proteins involved in immunity and infection. Particular areas of focus include cancer immunotherapeutics, carbohydrate-lectin interactions, glycosylation and glycosyltransferases
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  • 93
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196067
    Sprache: Englisch
    Seiten: 1 Online-Ressource (135 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Highly emotional events tend to be well remembered. The adaptive value in this is clear – those events that have a bearing on survival should be stored for future use as long-term memories whereas memories of inconsequential events would not as likely contribute to future survival. Enduring changes in the structure and function of synapses, neural circuitry, and ultimately behavior, can be modulated by highly aversive or rewarding experiences. In the last decade, the convergence of cellular, molecular, and systems neuroscience has produced new insights into the biological mechanisms that determine whether a memory will be stored for the long-term or lost forever. This Research Topic brings together leading experts, who work at multiple levels of analysis, to reveal recent discoveries and concepts regarding the synaptic mechanisms of consolidation and extinction of emotionally arousing memories
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  • 94
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193028
    Sprache: Englisch
    Seiten: 1 Online-Ressource (254 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Whilst significant advances have been made in whole organismal proteomics approaches, many researchers still rely on combinations of tissue selection and subcellular prefractionation methods to reduce the complexity of protein extracts from plants prior to proteomic analysis. Often this will allow identification of many lower abundance proteins of the target proteome and it may involve the selection of specific organs, cell types or the isolation of specific subcellular components. These subcellular proteomes provide insight into functions following various treatments and also contribute to the wider understanding of the entire organismal proteome by cataloguing a series of sub-proteome contents. The aim of this Research Topic is to bring together knowledge of sub cellular components in different plant species to provide a basis for accelerated research. It aims to provide a mini-review for each proposed section that summarizes the current understanding of a particular proteome, with the anticipation that every 5 - 10 years we can update these definitive publications
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  • 95
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195404
    Sprache: Englisch
    Seiten: 1 Online-Ressource (375 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Efficient auditory processing requires the rapid integration of transient sensory inputs. This is exemplified in human speech perception, in which long stretches of a complex acoustic signal are typically processed accurately and essentially in real-time. Spoken language thus presents listeners’ auditory systems with a considerable challenge even when acoustic input is clear. However, auditory processing ability is frequently compromised due to congenital or acquired hearing loss, or altered through background noise or assistive devices such as cochlear implants. How does loss of sensory fidelity impact neural processing, efficiency, and health? How does this ultimately influence behavior? This Research Topic explores the neural consequences of hearing loss, including basic processing carried out in the auditory periphery, computations in subcortical nuclei and primary auditory cortex, and higher-level cognitive processes such as those involved in human speech perception. By pulling together data from a variety of disciplines and perspectives, we gain a more complete picture of the acute and chronic consequences of hearing loss for neural functioning
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  • 96
    Online-Ressource
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195848
    Sprache: Englisch
    Seiten: 1 Online-Ressource (151 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Neglect is one of the most impressive neuropsychological disorder, for both its theoretical and clinical relevance. Besides being very common and disabling, it is highly informative for understanding normal cognitive functioning. The hallmark of neglect is the failure to attend to the contralesional hemispace. However, several studies have recently highlighted that additional deficits, not attributable to a spatial bias, are associated to the impaired contralesional hemispace processing. Moreover, manifestations of neglect tend to be particularly heterogeneous and often dissociate according to the spatial domain being investigated (e.g., body space, space within reaching, space beyond reaching, imaginal space). Heterogeneity in neglect patients also means that dissociations across different tasks in a single patient are more the rule than the exception. Evidence suggests that some of these dissociations can be readily explained by taking into account the amount of available attentional resources as a major determinant for the presence and the severity of neglect. There is no doubt that neglect patients provide a wealth of information about the functioning of systems subserving attentional orienting and spatial processing. Moreover, their performance also show that some non-spatial deficits are tightly coupled with more classic contralesional spatial deficits. It seems however still unclear to what extent these non-spatial deficits are an intrinsic characteristic of neglect or whether they are to be considered unspecific effects of the often massive brain lesions suffered by the patients. From the clinical point of view, neglect is a disorder that dramatically affects patients and their caregivers, because it severely limits the individuals’ autonomy and motor recovery after brain damage. For these reasons neglect is a disorder that is worth rehabilitating. To be effective, neglect rehabilitation should be based on the knowledge of what cognitive aspects are impaired and it should be focused on improving daily-life performance. For these reasons, it is also important to detect and quantify subtle forms of neglect
    Anmerkung: English
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  • 97
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    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192953
    Sprache: Englisch
    Seiten: 1 Online-Ressource (78 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Understanding the role of sleep and the mechanisms at play in ageing are among the most exciting challenges in neuroscience. Although our understanding of the mechanisms governing sleep stages and their role in cognitive processes including memory functions is gradually increasing. most of the currently available data have been gathered in young adults. Still, substantial physiological changes in sleep are observed with increasing age, that may markedly impacts on daily functioning. This is why this Research Topic focuses on our current understanding of the impact of age-related changes in sleep architecture on various domains of cognition. The three editors Julie Carrier (Montréal, Canada), Philippe Peigneux (Brussels, Belgium) and Géraldine Rauchs (Caen, France) are specialized in various fields of sleep research. Here, they bring together an outstanding group of neuroscientist and clinical investigators engaged in the study of sleep, encompassing state-of-the-art studies of sleep disorders such as sleep apnoea or REM sleep behaviour disorder, studies assessing new treatments to improve sleep quality, together with experts in various domains of cognition such as vigilance, memory and dreams, in a perspective aimed at offering the interested reader a comprehensive view of the impact of age-related changes in sleep architecture on cognition
    Anmerkung: English
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  • 98
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    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193868
    Sprache: Englisch
    Seiten: 1 Online-Ressource (122 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The global population aged over 60 is set to rise dramatically in the coming decades. In many countries, the older population now faces the prospect of spending a quarter of their lives aged over 65, and a significant proportion will have to cope with cognitive decline associated with normal ageing or with dementia disorders. Given that these fundamental demographic changes will pose a significant challenge to health care systems, a detailed understanding of age-related cognitive and neurobiological changes is essential in helping elderly populations maintain cognitive performance. In addition, developing sensitive biomarkers to identify those at risk of developing dementia is crucial for early and effective interventions. To make inferences about the ageing process from the animal model back to the human, rigorous behavioral paradigms must be used to ensure that the same function is being examined across species. Given that similar navigational paradigms can easily be applied to humans and animals, recent years have seen an expansion of studies attempting to bridge the gap between age-related changes in animal and human spatial cognition. These studies begin to suggest that disruptions in spatial computations are among the earliest indicators of impending cognitive decline. In addition, although many animal studies have identified pathological mechanisms with paradigms involving spatial navigation, these mechanisms support many nonspatial cognitive functions as well. As a consequence, a successful characterization of how spatial processing changes in the ageing brain could reveal fundamental effects of cognitive ageing that could inform about general mechanisms underlying decline in perception, mnemonic processing and multisensory integration
    Anmerkung: English
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  • 99
    ISBN: 9782889193998
    Sprache: Englisch
    Seiten: 1 Online-Ressource (163 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Understanding the molecul ...
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  • 100
    ISBN: 9782889196838
    Sprache: Englisch
    Seiten: 1 Online-Ressource (107 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential
    Anmerkung: English
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