Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • MPI Ethno. Forsch.  (119)
  • HeBIS
  • 2010-2014  (119)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
Datasource
  • MPI Ethno. Forsch.  (119)
  • HeBIS
Material
Language
Years
Year
  • 1
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192656
    Language: English
    Pages: 1 Online-Ressource (207 p.)
    Series Statement: Frontiers Research Topics
    Abstract: What the self is and where it comes from has been one of the great problems of philosophy for thousands of years. As science and medicine have progressed this question has moved to also become a central one in psychology, psychiatry, and neuroscience. The advent of in vivo brain imaging has now allowed the scientific investigation of the self to progress further than ever. Many such imaging studies have indicated that brain structures along the cortical midline are particularly closely related to self-specific processing. This association between cortical midline structures (CMS) and self is reinforced by the involvement of these regions in other self-oriented processes, such as mind-wandering or stimulus valuation. Those midline regions involved in self- processing also overlap with another network, the default mode network, which shows high brain activity during the so-called resting state, indicating that there may be a special relationship between self-processing and intrinsic activity. Although such promising groundwork linking the self and CMS has been carried out, many questions remain. These include: what features of the midline regions lead to their apparent importance in self-processing? How can we appropriately account for confounding factors such as familiarity or task-effects in our experiments? How is the self-related to other features of the mind, such as consciousness? How is our methodology influencing our attempts to link the self and the brain? The purpose of this ebook is to address some of these questions, including opinions, perspectives, and hypotheses about the concept of the self, the relationship between CMS and the self, and the specific function of these brain regions in self-processing. It also includes original research papers describing EEG, fMRI, and behavioral experiments investigating different aspects of the self
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192533
    Language: English
    Pages: 1 Online-Ressource (183 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Our understanding of visual perception and visual cognition has advanced considerably over the last decades. The effects of ageing on visual perception and visual cognition are less well understood. This Research Topic features state-of-the-art approaches to determining the effects of ageing on visual perception, visual attention, visual memory and visually guided behaviour. Studies using methods that incorporate psychophysics, eye movements, electrophysiology, structural and functional neuroimaging, as well as computational modelling are included. In addition to the focus on how ageing effects normal vision, the topic also includes studies on the effects of pathological ageing in the retina (e.g., age-related macular degeneration) and the brain (e.g., neurodegenerative disorders) on vision and visual cognition
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193271
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The impact of training or experience is not the same at all points in development. Children who receive music lessons, or learn a second language before age 7-8 are more proficient as adults. Early exposure to drugs or trauma makes people more likely to become addicted or depressed later life. Rat pups exposed to specific frequencies from 9-13 days post-partum show expanded cortical representations of these frequencies. Young birds must hear and copy their native song within 1-2 months of birth or they may never learn it at all. These are examples of sensitive periods: developmental windows where maturation and specific experience interact to produce differential long-term effects on the brain and behavior. While still controversial, evidence for the existence of sensitive periods has grown, as has our understanding of the underlying mechanisms of brain plasticity. Behavioral evidence from studies of language, psychopathology or vision in humans has been complemented by evidence elucidating molecular, gene and hormonal mechanisms in animals. It has been proposed that sensitive periods can be both opened and closed by specific experience, and that there are multiple, overlapping sensitive periods that occur through-out development as functions come on line. It is also likely that experience-dependent behavioral or brain plasticity accrued during one sensitive period can serve as a scaffold on which later experience and plasticity can build. Based on current knowledge, there are a number of broad questions and challenges to be addressed in this domain, these include: generating new information about the neurobiological mediators of structural and functional changes; proposing models of brain development that will better predict when sensitive periods should occur and what functions are implicated; investigation of the interaction between experience during a sensitive period and pre-existing individual differences; and the relationship between experience during a sensitive period and on-going experience. The goal of this Research Topic is to bring together scientists in different fields whose work addresses these issues, including animal and human developmental neuroscience, language and cognitive development, education, developmental psychopathology and sensory neuroscience
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    ISBN: 9782889192694
    Language: English
    Pages: 1 Online-Ressource (136 p.)
    Series Statement: Frontiers Research Topics
    Abstract: With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISBN: 9782889192557
    Language: English
    Pages: 1 Online-Ressource (143 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Our visual system is constantly bombarded by a variety of stimuli, of which only a small part is relevant to the task at hand. As a result, goal-directed behavior requires a high degree of selectivity at some point in the processing stream. The precise point at which selection takes place has been the focus of much debate. Early selection advocates argue that the locus of selection is at early stages of processing and that therefore, unattended stimuli are not fully processed. In contrast, late selection theorists argue that attention operates only after stimuli have been fully processed. Evidence supporting both sides has been accumulated over the years and the debate played a central role in the attention literature for decades. Perceptual load theory was put forward as an intermediate solution: the locus of selective attention depends on task requirements. When load is high, selection is early. When load is low, selection is late. This solution has been widely accepted and the early/late debate has been, for the most part, set aside. However, recently, perceptual load theory has been challenged on both theoretical and methodological grounds. It has been argued that it is not load, but rather perceptual dilution salience and other perceptual factors that determine the efficacy of attentional selection, which would call for a reevaluation of the current status of both perceptual load theory and its proposed alternatives, and more broadly, the early/late selection debate. The goal of this Research Topic is to provide an up-to-date overview of both empirical evidence and theoretical views on these key questions
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193523
    Language: English
    Pages: 1 Online-Ressource (95 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The main causes of morbid ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193226
    Language: English
    Pages: 1 Online-Ressource (74 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Intractable epilepsy still remains the main issue despite new advances in medical and surgical treatment of epilepsy. Acute seizure management in a timely manner is crucial to prevent irreversible brain damage. Benzodiazepines still remain the first initial treatment to abort the seizure activity. The approval phenytoin, fosphenytoin, intravenous valproate, and rectal diazepam provided additional options. The approval of intravenous levetiracetam gave another option to physicians if and when the above treatment fails to control the seizure activity. In this Ebook, we have included chapters from renowned researchers in the field of neurology and epilepsy who have covered the various aspects of these agents in detail including the properties, mechanism of action, pharmacology, neurobehavioral effects, and the roles of these agents in special populations including traumatic brain injury and brain tumor related epilepsy. These data further show that intravenous levetiracetam can be used in acute seizure management and in special circumstances
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192755
    Language: English
    Pages: 1 Online-Ressource (130 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The understanding of biological complexity has been greatly facilitated by cross-disciplinary, holistic approaches that allow insights into the function and regulation of biological processes that cannot be captured by dissecting them into their individual components. In addition, the development of novel tools has dramatically increased our ability to interrogate information at the nucleic acid, protein and metabolite level. The integration and interpretation of disparate data sets, however, still remain a major challenge in systems biology. Roots provide an excellent model for studying physiological, developmental, and metabolic processes. The availability of genetic resources, along with sequenced genomes has allowed important discoveries in root biochemistry, development and function. Roots are transparent, allowing optical investigation of gene activity in individual cells and experimental manipulation. In addition, the predictable fate of cells emerging from the root meristem and the continuous development of roots throughout the life of the plant, which permits simultaneous observation of different developmental stages, provide ideal premises for the analysis of growth and differentiation. Moreover, a genetically fixed cellular organization allows for studying the utilization of positional information and other non-cell-autonomous phenomena, which are of utmost importance in plant development. Although their ontogeny is largely invariant under standardized experimental conditions, roots possess an extraordinary capacity to respond to a plethora of environmental signals, resulting in distinct phenotypic readouts. This high phenotypic plasticity allows research into acclimative and adaptive strategies, the understanding of which is crucial for germplasm enhancement and crop improvement. With the aim of providing a current snapshot on the function and development of roots at the systems level, this Research Topic collated original research articles, methods articles, reviews, mini reviews and perspective, opinion and hypotheses articles that communicate breakthroughs in root biology, as well as recent advances in research technologies and data analysis
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192625
    Language: English
    Pages: 1 Online-Ressource (275 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Recent evidence has shown many ways in which our bodies and the environment influence cognition. In this Research Topic we aim to develop our understanding of cognition by considering the diverse and dynamic relationship between the language we use, our bodily perceptions, and our actions and interactions in the broader environment. There are already many empirical effects illustrating the continuity of mind- body-environment: manipulating body posture influences diverse areas such as mood, hormonal responses, and perception of risk; directing attention to a particular sensory modality can affect language processing, signal detection, and memory performance; placing implicit cues in the environment can impact upon social behaviours, moral judgements, and economic decision making. This Research Topic includes papers that explore the question of how our bodies and the environment influence cognition, such as how we mentally represent the world around us, understand language, reason about abstract concepts, make judgements and decisions, and interact with objects and other people. Contributions focus on empirical, theoretical, methodological or modelling issues as well as opinion pieces or contrasting perspectives. Topic areas include, perception and action, social cognition, emotion, language processing, modality-specific representations, spatial representations, gesture, atypical embodiment, perceptual simulation, cognitive modelling and perspectives on the future of embodiment
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192809
    Language: English
    Pages: 1 Online-Ressource (109 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. However, some non-canonical caspase-1-independent proinflammatory cell death phenomena have been reported. Microbial pathogens are able to modulate host apoptosis and pyroptosis through different triggers and pathways. The promotion and inhibition of host apoptosis and pyroptosis vary and depend on the microbe types, virulence, and phenotypes. For example, virulent pathogens and attenuated vaccine strains may use different pathways to modulate host cell death. Specific microbial genes may be responsible for the modulation of host cell death. Different host cells, including macrophages, dendritic cells, and T cells, can undergo apoptosis and pyroptosis after microbial infections. The pathways of host apoptosis and pyroptosis induced by different microbes may also differ. Different methods can be used to study the interaction between microbes and host cell death system. The articles included in this E-book report the cutting edge findings in the areas of microbial modulation of host apoptosis, pyroptosis and inflammasome
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 11
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193707
    Language: English
    Pages: 1 Online-Ressource (83 p.)
    Series Statement: Frontiers Research Topics
    Abstract: A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 12
    ISBN: 9782889193554
    Language: English
    Pages: 1 Online-Ressource (167 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low- dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses to modulation of bacterial virulence factors to acquisition of antibiotic resistance genes
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 13
    ISBN: 9782889194216
    Language: English
    Pages: 1 Online-Ressource (136 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Plants synthesize a wide variety of unique glycan structures which play essential roles during the life cycle of the plant. Being omnipresent throughout the plant kingdom, ranging from simple green algae to modern flowering plants, glycans contribute to many diverse processes. Glycans can function as structural components in the plant cell wall, assist in the folding of nascent proteins, act as signaling molecules in plant defense responses or (ER) stress pathways, or serve within the energy metabolism of a plant. In most cases, glycans are attached to other macromolecules to form so-called glycoconjugates (e.g. glycoproteins, proteoglycans and glycolipids), but they can also be present as free entities residing in the plant cell. Next to the broad, complex set of glycans, plants also evolved an elaborate collection of lectins or proteins with a lectin-like domain, which can recognize and bind to endogenous (plants-own) or exogenous (foreign) glycans. Though still poorly understood in plants, the dynamic interactions between lectins and carbohydrate structures are suggested to be involved in gene transcription, protein folding, protein transport, cell adhesion, signaling as well as defense responses. As such, a complex and largely undetermined glycan-interactome is established inside plant cells, between cells and their surrounding matrix, inside the extracellular matrix, and even between organisms. Studying the biological roles of plant glycans will enable to better understand plant development and physiology in order to fully exploit plants for food, feed and production of pharmaceutical proteins. In this Research Topic, we want to provide a platform for articles describing the latest research, perspectives and methodologies related to the fascinating world of plant glycobiology, with a focus on following subjects: 1. Identification and characterization of plant glycans, their biosynthetic and degradation enzymes 2. Characterization of plant lectins and glycoproteins 3. Plant glycans in the plant’s energy metabolism 4. Role of plant glycans in plant defense signaling 5. Use of plant lectins in pest control 6. Plant lectins as new tools in human medicine 7. Glyco-engineering in plants
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 14
    ISBN: 9782889193196
    Language: English
    Pages: 1 Online-Ressource (217 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The emotions that we feel and also those that we perceive in others are crucial to the social functioning of both humans and non-human animals. Although the role of context has been extensively studied in basic sensory processing, its relevance for social cognition and emotional processing is little understood. In recent years, several lines of research at the behavioral and neural levels have highlighted the bidirectional interactions that take place between emotions and social context. Experienced emotions, even when incidental, bias decision-making. Remarkably, even basic emotions can be strongly influenced by situational contexts. In addition, both humans and non-human animals can use emotional expressions strategically as a means of influencing and managing the behavioral response of others in relation to specific environmental situations. Moreover, social emotions (e.g., engaged in moral judgment, empathic concern and social norms) seem to be context-dependent, which also questions a purely abstract account of emotion understanding and expression, as well as other social cognition domains. The present Research Topic of Frontiers in Human Neuroscience highlights the need for a situated approach to emotion and social cognition. We presented theoretical and empirical work at the behavioral and neural levels that contribute to our understanding of emotion within a highly contextualized social realm, and vice-versa. Relevant contributions are presented from diverse fields, including ethology, neurology, biology, cognitive and social neuroscience, and as well as psychology and neuropsychiatry. This integrated approach that entails the interaction between emotion and social context provide important new insights into the growing field of social neuroscience
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 15
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192960
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Series Statement: Frontiers Research Topics
    Abstract: An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in pathology in focal cortical regions, but abnormalities in subcortical structures, such as thalamus and basal ganglia, and in intercortical and intracortical connecting white matter pathways. Novel methods of treating refractory epilepsy are urgently needed. The goal of identifying for each affected individual the specific brain regions that are involved offers the promise that novel methods of treatment will one day be developed that specifically target those abnormal regions. Researchers from disparate fields are required to develop and advance this area of research, and this current topic proposes to place a spotlight on the “state of the art” of methods to identify the abnormal networks. Recent work covering a wide variety of disciplines and technologies, including dense array electroencephalography (dEEG), novel methods of analyses of both the interictal dEEG and intracranial EEG (icEEG), magnetoencephalography (MEG), high-resolution magnetic resonance imaging (MRI), functional MRI (fMRI), simultaneous fMRI-EEG, fMRI connectivity measures, simultaneous dEEG-icEEG, and techniques to coregister patient-specific MRI (including white matter pathways) and dEEG, are all examples of areas of research that have contributed to a greater understanding of potential epileptogenic regions. We asked for individuals with expertise in an area of research that expands an understanding of identifying epileptic networks to contribute to this research topic
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 16
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192472
    Language: English
    Pages: 1 Online-Ressource (92 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The brainstem is one of the least understood parts of the human brain despite its prime importance for the maintenance of basic vital functions. Owing to its role as a relay station between spinal cord, cerebellum and neocortex, the brainstem contains vital nodes of all functional systems in the central nervous system, including the visual, auditory, gustatory, vestibular, somatic and visceral senses, and the somatomotor as well as autonomic nervous systems. While the brainstem has been extensively studied in animals using invasive methods, human studies remain scarce. Magnetic resonance imaging (MRI) as a non-invasive and widely available method is one possibility to access the brainstem in humans and measure its structure as well as function. The close vicinity of the brainstem to large arteries and ventricles and the small size of the anatomical structures, however, place high demands on imaging as well as data analysis methods. Nevertheless, the field of brainstem-(f)MRI has significantly advanced in the past few years, largely due to the development of several new tools that facilitate studying this critical part of the human brain. Within this scope, the goal of this Research Topic is to compile work representing the state of the art in functional and structural MRI of the human brainstem
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 17
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192908
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Theories of associative l ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 18
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194605
    Language: English
    Pages: 1 Online-Ressource (139 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The fruit is an important plant structure. Not only does it provide a suitable environment for seeds to develop and serve as a vehicle for seed disposal, but it is also an indispensable part of the human diet. Despite its agronomic and nutritional value and centuries of intensive genetic selection, little is known about the molecular mechanism of its development or the evolution of its diverse forms. The last few years have witnessed a surge of investigations on the early stages of fruit development propelled by the advancement of high throughput sequencing technology, genome sequencing of fruit bearing species, and detailed molecular insights based on studies of model organisms. This research topic is focused on early stage fruit development that ranges from pre-fertilization patterning of the female ovary through post-fertilization fruit initiation and growth. Provided by the renowned experts in the field, these papers are intended to highlight recent progress and shed light on different aspects of fruit development from structure, function, to molecular genetics, and evolution
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 19
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193660
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Transfer RNAs (tRNAs) are one of the classical non-coding RNAs whose lengths are approximately 70–100 bases. The secondary structure of tRNAs can be represented as the cloverleaf with 4 stems, and the three dimensional structure as an “L” shape. Historically, the basic function of tRNA as an essential component of translation was established in 1960s, i.e., each tRNA is charged with a target amino acid and these are delivered to the ribosome during protein synthesis. However, recent data suggests that the role of tRNA in cellular regulation goes beyond this paradigm. In most Archaea and Eukarya, precursor tRNAs are often interrupted by a short intron inserted strictly between the first and second nucleotide downstream of the anticodon, known as canonical nucleotide position (37/38). Recently, a number of reports describe novel aspects of tRNAs in terms of gene diversity, for example, several types of disrupted tRNA genes have been reported in the Archaea and primitive Eukarya, including multiple-intron-containing tRNA genes, split tRNA genes, and permuted tRNA genes. Our understanding of the enzymes involved in tRNA functions (e.g., aminoacyl-tRNA synthetase, tRNA splicing endonuclease, tRNA ligase) has deepened. Moreover, it is well known that tRNA possesses many types of base modifications whose enzymatic regulations remain to be fully elucidated. It was reported that impaired tRNA nuclear-cytoplasmic export links DNA damage and cell-cycle checkpoint. Furthermore, a variety of additional functions of tRNA, beyond its translation of the genetic code, have emerged rapidly. For instance, tRNA cleavage is a conserved part of the responses to a variety of stresses in eukaryotic cells. Age-associated or tissue-specific tRNA fragmentation has also been observed. Several papers suggested that some of these tRNA fragments might be involve in the cellular RNA interference (RNAi) system. These exciting data, have lead to this call for a Research Topic, that plans to revisit and summarize the molecular biology of tRNA. Beyond the topics outlined above, we have highlighted recent developments in bioinformatics tools and databases for tRNA analyses
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 20
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192762
    Language: English
    Pages: 1 Online-Ressource (131 p.)
    Series Statement: Frontiers Research Topics
    Abstract: One of the most challengi ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 21
    ISBN: 9782889192502
    Language: English
    Pages: 1 Online-Ressource (39 p.)
    Series Statement: Frontiers Research Topics
    Abstract: From ABO typing during th ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 22
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194001
    Language: English
    Pages: 1 Online-Ressource (122 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 23
    ISBN: 9782889192434
    Language: English
    Pages: 1 Online-Ressource (168 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, reuse and metabolize transmitter glutamate and GABA. Details of these subjects are described in this Research Topic by key investigators in this field. It focuses on the intricate and extremely swift pathway producing these amino acid transmitters from glucose in brain but also discusses difficulties in determining expression of some of the necessary genes in astrocytes and related processes in pancreatic islets. However, it does not discuss how closely associated astrocytes and neurons are anatomically, enabling these interactions. This is elegantly shown in this cover image, kindly provided by Professor Andreas Reichenbach (University of Leipzig, Germany)
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 24
    ISBN: 9782889192991
    Language: English
    Pages: 1 Online-Ressource (165 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The calcium-calmodulin dependent protein kinases (CaMKs) are a broadly expressed family of calcium-sensitive intracellular kinases, which are responsible for transducing cytosolic calcium signals into phosphorylation-based regulation of proteins and physiological functions. As the multifunctional member of the family, CaMKII has become the most prominent for its roles in the central nervous system and heart, where it controls a diverse range of calcium-dependent processes; from learning and memory at the neuronal synapse, to cellular growth and death in the myocardium. In the heart, CaMKII directly regulates many of the most important ion channels and calcium handling proteins, and controls the expression of an ever-increasing number of transcripts and their downstream products. Functionally, these actions are thought to orchestrate many of the electrophysiologic and contractile adaptations to common cardiac stressors, such as rapid pacing, chronic adrenergic stimulation, and oxidative challenge. In the context of disease, CaMKII has been shown to contribute to a remarkably wide variety of cardiac pathologies, of which heart failure (HF) is the most conspicuous. Hyperactivity of CaMKII is an established contributor to pathological cardiac remodeling, and is widely thought to directly promote arrhythmia and contractile dysfunction during HF. Moreover, several non-failing arrhythmia-susceptible phenotypes, which result from specific genetic channelopathies, functionally mimic constitutive channel phosphorylation by CaMKII. Because CaMKII contributes to both the acute and chronic manifestations of major cardiac diseases, but may be only minimally required for homeostasis in the absence of chronic stress, it has come to be one of the most promising therapeutic drug targets in cardiac biology. Thus, development of more specific and deliverable small molecule antagonists remains a key priority for the field. Here we provide a selection of articles to summarize the state of our knowledge regarding CaMKII in cardiac health and disease, with a particular view to highlighting recent developments in CaMKII activation, and new targets in CaMKII-mediated control of myocyte physiology
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 25
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193592
    Language: English
    Pages: 1 Online-Ressource (101 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Abiotic stresses are the major cause that limits productivity of crop plants worldwide. Plants have developed intricate machinery to respond and adapt over these adverse environmental conditions both at physiological and molecular levels. Due to increasing problems of abiotic stresses, plant biotechnologists and breeders need to employ new approaches to improve abiotic stress tolerance in crop plants. Although current research has divulged several key genes, gene regulatory networks and quantitative trait loci that mediate plant responses to various abiotic stresses, the comprehensive understanding of this complex trait is still not available. This e-book is focused on molecular genetics and genomics approaches to understand the plant response/adaptation to various abiotic stresses. It includes different types of articles (original research, method, opinion and review) that provide current insights into different aspects of plant responses and adaptation to abiotic stresses
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 26
    ISBN: 9782889192687
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Demyelinating diseases are characterized by an extensive loss of oligodendrocytes and myelin sheaths from axolemma, which commonly result in disability in young adults. To date, there is no effective treatment against these neurological disorders. In the adult brain, there are neural stem cells (NSCs) that reside within a niche denominated ventricular-subventricular zone (V-SVZ) in the lateral wall of the cerebral ventricles. NSCs give rise to neurons and oligodendrocytes that help preserve cellular homeostasis. Growing evidence indicates that V-SVZ progenitor cells may represent an endogenous source of oligodendrocytes that can be useful to treat demyelinating diseases. This e-Book collected the most recent evidence regarding the mechanisms that modulate the proliferation, migration, quiescence, cell-fate choices and survival of oligodendrocyte precursors generated in the V-SVZ. Herein, we compiled information about the role of Sonic hedgehog, NMDA receptors, ErbB proteins, hemopressin, erythropoietin, osmolarity and microglia in the oligodendrocyte production. Some chapters also describe the role of oligodendrocyte precursors in the preservation of cellular homeostasis, aging and white matter repair. All these information is presented as novel research findings, short communications, and review articles, which were written by experts in the field of oligodendrocyte generation, myelin production and white matter re-myelination
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 27
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192892
    Language: English
    Pages: 1 Online-Ressource (239 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Vibrios are Gram-negative bacilli that occur naturally in marine, estuarine, and freshwater systems. Some species include human and animal pathogens capable of causing gastroenteritis, wound infections, cholera, and fatal septicemia. Over the past decades, cutting edge research on Vibrio genomics has promoted a tremendous advance in our knowledge of these pathogens. Significant developments include the discovery of emerging epidemic clones, tracking the spread of new strain variants, and an intensified appreciation of the role of mobile genetic elements in antibiotic resistance spread as well as pathogenesis. Furthermore, improved understanding of the interaction of Vibrios with a variety of living organisms in the aquatic environment has documented the significant role of environmental reservoirs in their seasonal cycle favoring persistence of the pathogen during inter-epidemic periods and enhancing disease transmission. This Research Topic is dedicated to our current understanding in these areas and will bring together leading experts in the field to provide a deep overview of Vibrios ecology and evolution, and will suggest the pathway of future research in this field
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 28
    ISBN: 9782889192403
    Language: English
    Pages: 1 Online-Ressource (131 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This Research Topic is devoted to the understanding of molecular mechanisms of Human Thyroid Cancers. Original research describing functional studies of genetic mutations that shed novel insights into the aetiology and pathogenesis of these cancers, as well as angiogenesis and tumor microenvironment, mouse models studies that describe mechanisms or novel potential therapeutic targets and biomarkers for these endocrine cancers are presented. Scopes: The scope of this Research Topic was to cover the entire field of thyroid cancers: the main focus of this topic is translational, with an emphasis on bench to bedside research. Experimental, pre-clinical and clinical research addressing the following aspects is included in this Research Topic: 1) Investigation of specific molecular patterns of thyroid tumorigenesis, which could allow the development of new directions in the field of pharmacotherapy research; 2) Emphasis on animal studies (preclinical models of human anaplastic thyroid cancers) for the validation of biomarkers with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of these malignancies, tumor microenvironment and extracellular matrix, and metastatic disease; 3) Assessment of biomarkers to predict the potential response or resistance to drug treatment (targeted cancer therapies) or to guide the follow-up of treated patients; 4) Investigation of new laboratory molecular tests (e.g. molecular techniques and applications of thyroid fine-needle aspiration biopsy) to translate in the clinical practice; In summary, specific areas of interest include: thyroid cancer genetics; genome-wide analysis; clinical and translational research; orthotopic mouse models of metastatic thyroid carcinoma; tumor microenvironment; epigenetic; biological insights of personalized medicine; novel applications of bioinformatics; large scale molecular characterization of tumors; diagnostic or prognostic biomarkers; endocrine pathology studies; thyroid fine-needle aspiration
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 29
    ISBN: 9782889192984
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Increasingly, efforts to ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 30
    ISBN: 9782889192854
    Language: English
    Pages: 1 Online-Ressource (316 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There is a scarcity of detailed information regarding the ecophysiology of root systems and the way root system functioning is affected by both internal and external factors. Furthermore, global climate change is expected to increase the intensity of climate extremes, such as severe drought, heat waves and periods of heavy rainfall; in addition other stresses such as salinization of soils are increasing world-wide. Recently an increasing awareness has developed that understanding plant traits will play a major role in breeding of future crop plants. For example, there is increasing evidence that the traits of root systems are defined by the properties of individual roots. However, further knowledge on the functional importance of root segments and the molecular/physiological mechanisms underlying root system functioning and persistence is needed, and would specifically allow modifying (crop) root system functionality and efficiency in the future. Another major gap in knowledge is localized at the root-soil interface and in regard to the potential adaptive plasticity of root-rhizosphere interactions under abiotic stress and/or competition. It is currently unknown whether adaptations in microbe communities occur, for example due to modified exudation rates, and what are the subsequent influences on nutrient mobilization and uptake. Furthermore, uncovering the mechanisms by which roots perceive neighboring roots may not only contribute to our understanding of plant developmental strategies, but also has important implications on the study of competitive interactions in natural communities, and in optimizing plant performance and resource use in agricultural and silvicultural systems. In this Research Topic, we aimed to provide an on-line, open-access snapshot of the current state of the art of the field of root ecology and physiology, with special focus on the translation of root structure to function, and how root systems are influenced by interplay with internal and external factors such as abiotic stress, microbes and plant-plant interaction. We welcomed original research papers, but reviews of specific topics, articles formulating opinions or describing cutting-edge methods were also gladly accepted
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 31
    ISBN: 9782889193622
    Language: English
    Pages: 1 Online-Ressource (161 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 32
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194513
    Language: English
    Pages: 1 Online-Ressource (119 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 33
    ISBN: 9782889193684
    Language: English
    Pages: 1 Online-Ressource (172 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Plasmodesmata (PD) are plant-specific intercellular nanopores defined by specialised domains of the plasma membrane (PM) and the endoplasmic reticulum (ER), both of which contain unique proteins, and probably different lipid compositions than the surrounding bulk membranes. The PD membranes form concentric tubules with a minimal outer diameter of only 50 nm, and the central ER strand constricted to ~10-15 nm, representing one of the narrowest stable membrane tubules in nature. This unique membrane architecture poses many biophysical, structural and functional questions. PM continuity across PD raises the question as to how a locally confined membrane site is established and maintained at PD. There is increasing evidence that the PM within PD may be enriched in membrane ‘rafts’ or TET web domains. Lipid rafts often function as signalling platforms, in line with the emerging view of PD as central players in plant defense responses. Lipid-lipid immiscibility could also provide a mechanism for membrane sub- compartmentalisation at PD. Intricate connections of the PM to the wall and the underlying cytoskeleton and ER may anchor the specialised domains locally. The ER within PD is even more strongly modified. Its extreme curvature suggests that it is stabilised by densely packed proteins, potentially members of the reticulon family that tubulate the cortical ER. The diameter of the constricted ER within PD is similar to membrane stalks in dynamin-mediated membrane fission during endocytosis and may need to be stabilised against spontaneous rupture. The function of this extreme membrane constriction, and the reasons why the ER is connected between plant cells remain unknown. Whilst the technically challenging search for the protein components of PD is ongoing, there has been significant recent progress in research on biological membranes that could benefit our understanding of PD function. With this Research Topic, we therefore aim to bring together researchers in the PD field and those in related areas, such as membrane biophysics, membrane composition and fluidity, protein-lipid interactions, lateral membrane heterogeneity, lipid rafts, membrane curvature, and membrane fusion/fission
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 34
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192465
    Language: English
    Pages: 1 Online-Ressource (157 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 35
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193486
    Language: English
    Pages: 1 Online-Ressource (117 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 36
    ISBN: 9782889193387
    Language: English
    Pages: 1 Online-Ressource (196 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This Research Topic covers all of the major lectures and symposia addresses delivered by invited speakers at the 2013 International Congress in Immunology (ICI) at Milan, Italy, August 22-27, 2013
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 37
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193059
    Language: English
    Pages: 1 Online-Ressource (91 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Carboxylic acids are ubiquitous molecules found in microbial metabolic pathways and that have been explored for a wide array of applications including food preservation (e.g., acetic, propionic, benzoic, and sorbic acids), chemotherapy (e.g., the analgesic acetylsalicylic acid, the immunosuppressor mycophenolic acid or the antimalarial drugs artesunic and artemisinic acids) or agriculture (e.g., the herbicides 2,4-dichlorophenoxyacetic acid). This Research Topic contributes to the understanding of the molecular mechanisms underlying adaptation to weak acid stress in microbes, a knowledge base that impacts the fields of Medicine, Health, Food Safety and the Environment
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 38
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192830
    Language: English
    Pages: 1 Online-Ressource (121 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Mitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and pathological conditions through their participation in many intracellular signaling pathways. Studies over the last 30 years provide strong evidence that mitochondria are the nexus of various stresses which initiate cell death through apoptosis, oncosis, necrosis and autophagy depending on the severity of the stress and cellular energy status. The release of several pro-apoptotic proteins such as cytochrome c, Smac/DIABLO, AIF, endonuclease G from intermembrane space initiates both caspase-dependent and caspase-independent apoptosis. The formation of the mitochondrial permeability transition pore in the IMM promotes cell death mostly through necrosis whereas a mild stress activates autophagy. Due to their critical roles in both cell death and survival mitochondria have been widely considered as an important target for various pharmacological and conditional therapeutic approaches. Currently, a large number of mitochondria-targeted agents are suggested to prevent (in ischemia reperfusion injury, cardiovascular, neurodegenerative and other diseases) or stimulate (in various cancers) cell death. This Research Topic focuses on the role of mitochondria in the regulation of cell metabolism and signaling under physiological and pathological conditions. Studies performed on cultured cells and isolated organs/tissues using different animal and cellular models of various diseases are also included and discussed
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 39
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194285
    Language: English
    Pages: 1 Online-Ressource (120 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 40
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193035
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Polyamines are small aliphatic polycations which have been involved in key stress and developmental processes in plants. In the recent years, compelling genetic and molecular evidences point to polyamines as essential metabolites required for resistance to drought, freezing, salinity, oxidative stress among other type of abiotic and biotic stresses. In addition to their role as stress-protective compounds, polyamines participate in key developmental processes mediated by specific signaling pathways or in cross-regulation with other plant hormones. Our Research Topic aims to integrate the multiple stress and developmental regulatory functions of polyamines in plants under a genetic, molecular and evolutionary perspective with special focus on signaling networks, mechanisms of action and metabolism regulation
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 41
    ISBN: 9782889192427
    Language: English
    Pages: 1 Online-Ressource (114 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific 'by-products' of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 42
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192816
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The visual, olfactory, auditory and gustatory systems of invertebrates are often used as models to study the transduction, transmission and processing of information in nervous systems, and in recent years have also provided powerful models of neural plasticity. This Research Topic presents current views on plasticity and its mechanisms in invertebrate sensory systems at the cellular, molecular and network levels, approached from both physiological and morphological perspectives. Plasticity in sensory systems can be activity- dependent, or occur in response to changes in the environment, or to endogenous stimuli. Plastic changes have been reported in receptor neurons, but are also known in other cell types, including glial cells and sensory interneurons. Also reported are dynamic changes among neuronal circuits involved in transmitting sensory stimuli and in reorganizing of synaptic contacts within a particular sensory system. Plastic changes within sensory systems in invertebrates can also be reported during development, after injury and after short or long- term stimulation. All these changes occur against an historical backdrop which viewed invertebrate nervous systems as largely hard-wired, and lacking in susceptibility especially to activity-dependent changes. This Research Topic examines how far we have moved from this simple view of simple brains, to the realization that invertebrate sensory systems exhibit all the diversity of plastic changes seen in vertebrate brains, but among neurons in which such changes can be evaluated at single-cell level
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 43
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193073
    Language: English
    Pages: 1 Online-Ressource (171 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Humans are remarkably adept at identifying individuals on the basis of their facial features, or other traits such as gait or vocal timbre. Besides voice, another auditory medium capable of carrying identity information is music. Indeed, certain famous musicians, such as John Coltrane or Sonny Rollins, need only to play a few notes to be unequivocally recognized. Along with emotion and structural cues, artistic individuality seems to be a key element communicated in music performance. Yet, the means by which individuality is expressed in performance, as well as the cognitive processes employed by listeners to perceive identity cues, remain poorly elucidated. Other pertinent issues, including the connection between a performer’s technical competence and ability to convey a specific musical identity, as well as potential links between individuality and career-defining outcomes such as critical recognition and aesthetic appraisal, warrant further exploration. Quantitative approaches to the study of music performance have benefited greatly from MIDI technology and the application of computational methods, leading to the flourishing of empirical music performance research over the last few decades. More recently, neuroimaging techniques have provided valuable insights into the neural mechanisms involved in the cognitive processes of performing music. Nevertheless, this field continues to benefit greatly from qualitative approaches, given that the communication of affect and identity cues in music performance leads to a rich subjectivity of impressions that must be accounted for in order to lead to a greater understanding of this multifaceted phenomenon. The aim of this Research Topic is to provide a forum for interdisciplinary research broadly related to the expression and perception of individuality in music performance. Research methodology includes behavioral, psychophysiological, and neuroimaging techniques. Both quantitative and qualitative approaches are presented The scope of this Research Topic includes laboratory studies as well as studies in real-life performance settings and longitudinal studies on performers
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 44
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193370
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas’ disease. Chagas’ disease stands out for being endemic among countries in Latin America, affecting about 15 million people. Recently, Chagas has become remarkable in European countries as well due to cases of transmission via infected blood transfusion. An important factor that has exacerbated the epidemiological picture in Brazil, Colombia and Venezuela is infection after the oral intake of contaminated foods such as sugar cane, açai and bacaba juices. Trypanosoma cruzi is an intracellular protozoan that exhibits a complex life cycle, involving multiple developmental stages found in both vertebrate and invertebrate hosts. In vertebrate hosts, the trypomastigote form invades a large variety of nucleated cells using multiple mechanisms. The invasion process involves several steps: (a) attraction of the protozoan to interact with the host cell surface; (b) parasite-host cell recognition; (c) adhesion of the parasite to the host cell surface; (d) cell signalling events that culminate in the internalization of the parasite through endocytic processes; (e) biogenesis of a large vacuole where the parasite is initially located, and is also known as parasitophorous vacuole (PV); (f) participation of endocytic pathway components in the internalization process; (g) participation of cytoskeleton components in the internalization process; (h) transformation of the trypomastigote into the amastigote form within the PV; (i) lysis of the membrane of the PV; (j) multiplication of amastigotes within the host cell in direct contact with cell structures and organelles; (k) transformation of amastigotes into trypomastigotes, and (l) rupture of the host cell releasing trypomastigotes into the extracellular space. The kinetics of the interaction process and even the fate of the parasite within the cell vary according to the nature of the host cell and its state of immunological activation
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 45
    ISBN: 9782889192724
    Language: English
    Pages: 1 Online-Ressource (135 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Bacteria can sequester me ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 46
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193257
    Language: English
    Pages: 1 Online-Ressource (89 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 47
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193837
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Experimental data have consistently revealed that the neuronal connection weight, which models the efficacy of the firing of a pre-synaptic neuron in modulating the state of a post-synaptic one, varies on short time scales, ranging from hundreds to thousands of milliseconds. This is called short-term plasticity (STP). Two types of STP, with opposite effects on the connection efficacy, have been observed in experiments. They are short-term depression (STD) and short-term facilitation (STF). Computational studies have explored the impact of STP on network dynamics, and found that STP can generate very rich intrinsic dynamical behaviors, including damped oscillations, state hopping with transient population spikes, traveling fronts and pulses, spiral waves, rotating bump states, robust self-organized critical activities and so on. These studies also strongly suggest that STP can play many important roles in neural computation. For instances, STD may provide a dynamic control mechanism that allows equal fractional changes on rapidly and slowly firing afferents to produce post-synaptic responses, realizing Weber's law; STD may provide a mechanism to close down network activity naturally, achieving iconic sensory memory; and STF may provide a mechanism for implementing work-memory not relying on persistent neural firing. From the computational point of view, the time scale of STP resides between fast neural signaling (in the order of milliseconds) and rapid learning (in the order of minutes or above), which is the time scale of many important temporal processes occurring in our daily lives, such as motion control and working memory. Thus, STP may serve as a substrate for neural systems manipulating temporal information on the relevant time scales. This Research Topic aims to present the recent progress in understanding the roles of STP in neural information processing. It includes, but no exclusively, the studies on investigating various computational roles of STP, the modeling studies on exploring new dynamical behaviors generated by STP, and the experimental works which help us to understand the functional roles of STP
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 48
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193363
    Language: English
    Pages: 1 Online-Ressource (153 p.)
    Series Statement: Frontiers Research Topics
    Abstract: ‘You are what you eat’. It’s a saying that we’ve all heard time and time again. The notion that good nutrition is essential for adequate growth and sound physical wellbeing is very well established. Further, in recent years, there has been an overwhelming increase in research dedicated to better understanding how nutritional factors influence cognition and behaviour. For example, several studies have suggested that higher foetal exposure to omega-3 fatty acids and B vitamins such as folate promotes neurodevelopment. B vitamins may also play a role in neurocognitive functioning in later life, with some suggestion that lower vitamin B levels are associated with increased risk of dementia (although randomised controlled trials investigating B vitamin supplementation as a cognitive enhancer in the elderly have provided inconclusive evidence as to the benefits of such therapy for dementia). In fact, the nutritional underpinnings of Alzheimer’s disease and other disorders of cognitive ageing is becoming a much researched topic. In addition, consumption of several other foods has been found to convey more acute cognitively enhancing effects. For example, ingestion of carbohydrates (e.g. glucose), caffeine, resveratrol and several ‘nutraceutical’ herbal extracts has been associated with short-term improvements in cognitive performance. Beyond specific micronutrients and macronutrients, the current literature seems to support anecdotal evidence that consumption of a balanced breakfast is crucial to various measures of school performance, including attention in the classroom. What is clear from this emerging literature is that the relationship between nutritional status and neurocognitive functioning at various stages of the lifespan is complex. An aim of this Research Topic is to bring together some recent empirical findings, reviews and commentaries of the literature to date and opinion pieces relating to future directions for this burgeoning field
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 49
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192632
    Language: English
    Pages: 1 Online-Ressource (294 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Two of the most important social skills in humans are the ability to determine the moods of those around us, and to use this to guide our behavior. To accomplish this, we make use of numerous cues. Among the most important are vocal cues from both speech and non-speech sounds. Music is also a reliable method for communicating emotion. It is often present in social situations and can serve to unify a group's mood for ceremonial purposes (funerals, weddings) or general social interactions. Scientists and philosophers have speculated on the origins of music and language, and the possible common bases of emotional expression through music, speech and other vocalizations. They have found increasing evidence of commonalities among them. However, the domains in which researchers investigate these topics do not always overlap or share a common language, so communication between disciplines has been limited. The aim of this Research Topic is to bring together research across multiple disciplines related to the production and perception of emotional cues in music, speech, and non-verbal vocalizations. This includes natural sounds produced by human and non-human primates as well as synthesized sounds. Research methodology includes survey, behavioral, and neuroimaging techniques investigating adults as well as developmental populations, including those with atypical development. Studies using laboratory tasks as well as studies in more naturalistic settings are included
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 50
    ISBN: 9782889193516
    Language: English
    Pages: 1 Online-Ressource (193 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In all living organisms, ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 51
    ISBN: 9782889193578
    Language: English
    Pages: 1 Online-Ressource (236 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Correlated activity in populations of neurons has been observed in many brain regions and plays a central role in cortical coding, attention, and network dynamics. Accurately quantifying neuronal correlations presents several difficulties. For example, despite recent advances in multicellular recording techniques, the number of neurons from which spiking activity can be simultaneously recorded remains orders magnitude smaller than the size of local networks. In addition, there is a lack of consensus on the distribution of pairwise spike cross correlations obtained in extracellular multi-unit recordings. These challenges highlight the need for theoretical and computational approaches to understand how correlations emerge and to decipher their functional role in the brain
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 52
    ISBN: 9782889192823
    Language: English
    Pages: 1 Online-Ressource (264 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 53
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192779
    Language: English
    Pages: 1 Online-Ressource (106 p.)
    Series Statement: Frontiers Research Topics
    Abstract: As the amount of biological information and its diversity accumulates massively there is a critical need to facilitate the integration of this data to allow new and unexpected conclusions to be drawn from it. The Semantic Web is a new wave of web- based technologies that allows the linking of data between diverse data sets via standardised data formats (“big data”). Semantic Biology is the application of semantic web technology in the biological domain (including medical and health informatics). The Special Topic encompasses papers in this very broad area, including not only ontologies (development and applications), but also text mining, data integration and data analysis making use of the technologies of the Semantic Web. Ontologies are a critical requirement for such integration as they allow conclusions drawn about biological experiments, or descriptions of biological entities, to be understandable and integratable despite being contained in different databases and analysed by different software systems. Ontologies are the standard structures used in biology, and more broadly in computer science, to hold standardized terminologies for particular domains of knowledge. Ontologies consist of sets of standard terms, which are defined and may have synonyms for ease of searching and to accommodate different usages by different communities. These terms are linked by standard relationships, such as “is_a” (an eye “is_a” sense organ) or “part_of” (an eye is “part_of” a head). By linking terms in this way, more detailed, or granular, terms can be linked to broader terms, allowing computation to be carried out that takes these relationships into account
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 54
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192489
    Language: English
    Pages: 1 Online-Ressource (173 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Active touch can be described as the control of the position and movement of tactile sensing systems to facilitate information gain. In other words, it is finding out about the world by reaching out and exploring - sensing by ‘touching’ as opposed to ‘being touched’. In this Research Topic (with cross-posting in both Behavioural Neuroscience and Neurorobotics) we welcomed articles from junior researchers on any aspect of active touch. We were especially interested in articles on the behavioral, physiological and neuronal underpinnings of active touch in a range of species (including humans) for submission to Frontiers in Behavioural Neuroscience. We also welcomed articles describing robotic systems with biomimetic or bio-inspired tactile sensing systems for publication in Frontiers in Neurorobotics
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 55
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193455
    Language: English
    Pages: 1 Online-Ressource (79 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors or oncogenes during carcinogenesis. Important tumor suppressor miRNAs are silenced by epigenetic alterations, resulting in activation of target oncogenes in human malignancies. Stem cells have the ability to perpetuate themselves through self-renewal and to generate mature cells of various tissues through differentiation. Accumulating evidence suggests that a subpopulation of cancer cells with distinct stem-like properties is responsible for tumor initiation, invasive growth, and metastasis formation, which is defined as cancer stem cells. Cancer stem cells are considered to be resistant to conventional chemotherapy and radiation therapy, suggesting that these cells are important targets of cancer therapy. DNA methylation, histone modification and miRNAs may be deeply involved in stem-like properties in cancer cells. Restoring the expression of tumor suppressor genes and miRNAs by chromatin modifying drugs may be a promising therapeutic approach for cancer stem cells. In this Research Topic, we discuss about alterations of epigenetics and miRNAs in cancer and cancer stem cell and understand the molecular mechanism underlying the formation of cancer stem cell, which may provide a novel insight for treatment of refractory cancer
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 56
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193431
    Language: English
    Pages: 1 Online-Ressource (239 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Foreword by Richard J. St ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 57
    ISBN: 9782889193066
    Language: English
    Pages: 1 Online-Ressource (266 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The brain of each animal shows specific traits that reflect its phylogenetic history and its particular lifestyle. Therefore, comparing brains is not just a mere intellectual exercise, but it helps understanding how the brain allows adaptive behavioural strategies to face an ever-changing world and how this complex organ has evolved during phylogeny, giving rise to complex mental processes in humans and other animals. These questions attracted scientists since the times of Santiago Ramon y Cajal one of the founders of comparative neurobiology. In the last decade, this discipline has undergone a true revolution due to the analysis of expression patterns of morphogenetic genes in embryos of different animals. The papers of this e-book are good examples of modern comparative neurobiology, which mainly focuses on the following four Grand Questions: a) How are different brains built during ontogeny? b) What is the anatomical organization of mature brains and how can they be compared? c) How do brains work to accomplish their function of ensuring survival and, ultimately, reproductive success? d) How have brains evolved during phylogeny? The title of this e-book, Adaptive Function and Brain Evolution, stresses the importance of comparative studies to understand brain function and, the reverse, of considering brain function to properly understand brain evolution. These issues should be taken into account when using animals in the research of mental function and dysfunction, and are fundamental to understand the origins of the human mind
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 58
    ISBN: 9782889193509
    Language: English
    Pages: 1 Online-Ressource (129 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The main scope of this to ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 59
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192618
    Language: English
    Pages: 1 Online-Ressource (113 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer's Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a "toxic" form of tau protein. Moreover, it was suggested that a "toxic" tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, "tau oligomers" as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of "tau oligomers"
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 60
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193325
    Language: English
    Pages: 1 Online-Ressource (111 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen receptor modulator tamoxifen was developed in the 1970’s for the treatment of breast cancer a positive correlation between receptor status and treatment outcome was found. As a result of this research, it was suggested to use the estrogen-receptor assay as a diagnostic test for selection of patients for tamoxifen treatment. Despite this suggestion was put forward nearly 40 years ago the adaptation of the drug-diagnostic co-development model has been relatively slow and it is only within the last decade that it has gained more widespread acceptance. The parallel development of the monoclonal antibody trastuzumab (Herceptin®, Roche/Genentech) and the immunohistochemistry assay for HER2 protein overexpression (HercepTest™, Dako) seems to have served as an inspiration to a number of stakeholders such as pharma and diagnostic companies, regulatory agencies, and academia. In recent years we have seen an increasing number of oncology drug development projects that have taken advantage of the drug-diagnostic co-development model, as outline below. Most of the new targeted anti-cancer drugs that have been introduced in recent years, such as BRAF-, ALK-, EGFR- and HER2-inhibitors, are more or less all a product of the drugdiagnostic co-development model. These drugs have shown remarkable high response rates in selected groups of patients within cancer diseases with great unmet medical needs. This Research Topic on Drug-Diagnostic Co-Development in Oncology aims to provide you with an insight into some of the diverse activities that constitute this new research area
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 61
    ISBN: 9782889193233
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Various cellular processes underlying plant development and response to environmental cues rely on a dynamic interplay between membranes and the cytoskeleton, e.g. vesicle and organelle trafficking, endocytosis, exocytosis, and signal transduction. In recent years, significant progress in the understanding of such interplay has been achieved and several critical links between membranes and the cytoskeleton have been characterized. As an example, recent work has clarified how auxin promotes the reorganization of cortical actin filaments by the activation of Rho GTPase pathways, and how such reorganization in turn locally modifies endocytosis and/or exocytosis and directs asymmetric distribution of PIN family of auxin transporters. Another recent achievement is the characterization of the Rho- and microtubule-driven mechanism by which the cell wall architecture is established. In particular, the elegant work by Oda and Fukuda (Science 337 p.1333, 2012) provides evidence that secondary wall patterning in xylem vessel primarily relies on two processes: a local activation of the plant Rho GTPase ROP11 and a mutual, MIDD1-mediated, inhibitory interaction between active ROP domains and cortical microtubules. Additional examples include recent genetic evidence that microtubule and actin filament interacting/regulatory proteins, such as MAP65-1 and capping protein, function as transducers of membrane lipid signaling into changes in cytoskeleton dynamics and organization. This Research Topic aims at collecting a comprehensive set of articles dealing with cellular processes involving membrane-cytoskeleton interactions. Its scope extends beyond the specific fields defined by the above examples and includes intracellular trafficking, host-pathogen interactions, response to biotic and abiotic stresses and hormonal regulation of growth. We hope that this Research Topic will also highlight critical questions that need to be addressed in the future. We welcomed Original Research Articles, Technical/Methodological Advances (e.g. analysis of cytoskeleton dynamics close to membranes), Reviews and Mini Reviews that can expand our understanding of how and why membranes and the cytoskeleton interact
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 62
    ISBN: 9782889192939
    Language: English
    Pages: 1 Online-Ressource (107 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Shiga toxin-producing Escherichia coli (STEC) is an important foodborne pathogen associated with both outbreaks and sporadic cases of human disease, ranging from uncomplicated diarrhoea to haemorrhagic colitis (HC) and haemolytic uraemic syndrome (HUS). STEC affects children, elderly and immuno-compromised patients. STEC is capable of producing Shiga toxin type 1 (Stx1), type 2 (Stx2) or both, encoded by stx1 and stx2 genes, respectively. These strains are likely to produce putative accessory virulence factors such as intimin (encoded by eae), an enterohaemolysin (EhxA) and an autoagglutinating protein commonly associated with eae-negative strains (Saa), both encoded by an enterohaemorrhagic plasmid. Several studies have confirmed that cattle are the principal reservoir of STEC (O157 and non-O157:H7 serotypes) and many of these serotypes have been involved in HUS and HC outbreaks in other countries. Transmission of STEC to humans occurs through the consumption of undercooked meat, vegetables and water contaminated by faeces of carriers and by person-to-person contact. Diagnostic methods have evolved to avoid selective diagnostics, currently using molecular techniques for typing and subtyping of strains. Control is still a challenge, although there are animal vaccines directed against the serotype O157:H7
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 63
    ISBN: 9782889193172
    Language: English
    Pages: 1 Online-Ressource (113 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Angiogenesis is the physi ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 64
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193332
    Language: English
    Pages: 1 Online-Ressource (69 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Pancreatic diseases inclu ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 65
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192977
    Language: English
    Pages: 1 Online-Ressource (241 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Global biogeochemical cyc ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 66
    ISBN: 9782889192380
    Language: English
    Pages: 1 Online-Ressource (252 p.)
    Series Statement: Frontiers Research Topics
    Abstract: "Cells live together, but die singly", this sentence wrote the German physiologist Theodor Engelmann in 1875 and although he had no particular knowledge of gap junction channels (their structure was discovered around 100 years later) he described their functions very well: gap junction channels are essential for intercellular communication and crucial for the development of tissue and organs. But besides providing an opportunity for cells to communicate gap junction channels might also prevent intercellular communication by channel closure thereby preserving the surrounding healthy tissue in case of cellular necrosis. According to today’s understanding gap junction channels play an important role during embryonic development, during growth, wound healing and cell differentiation and are also involved in the process of learning. In the past decades most intensive research was done not only to unravel the physiological role of gap junction channels but also to extend our knowledge of the contribution of these channels in pathogenesis. A new frontier emerges in the field "pharmacology of gap junctions" with the aim to control growth, differentiation, or electrical coupling via targeting gap junction channels pharmacologically. As we know today disturbances in gap junction synthesis, assembly and cellular distribution may account for various organic disorders from most different medical fields, such as the Charcot-Marie-Tooth neuropathy, epilepsy, Chagas-disease, Naxos-syndrome, congenital cardiac malformations, arrhythmias, cancer and as a very common disease in industrial countries atherosclerosis. Point mutations in gap junction channels have been found to cause hereditary diseases like the congenital deafness or the Charcot-Marie-Tooth neuropathy but the exact molecular mechanisms of gap junction malfunction from most of the mentioned illnesses are not fully understood. Moreover, in the last few years research has expanded on the role and function of connexin hemichannels and on a relatively new field the pannexins. The purpose of this volume is to give a comprehensive overview of the involvement of gap junction channels, hemichannels and pannexins on pathogenesis of inborn and acquired diseases and on emerging pharmacological strategies to target these channels. We welcome our colleagues to contribute their findings on the influence of gap junctions on pathogenesis and to unravel the secrets of intercellular communication. Take the lid off!
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 67
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193936
    Language: English
    Pages: 1 Online-Ressource (189 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 68
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192564
    Language: English
    Pages: 1 Online-Ressource (155 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The functional cross-talk and structural interaction between the main and accessory olfactory bulb is a central problem in mammalian sensory neurobiology. The early supposition that volatile substances and pheromones, most of them hydrosoluble molecules, are exclusively sensed and decoded by the main (MOS) and accessory olfactory systems (AOS), respectively, needs to be revised. In fact, a large number of structural and functional evidences accumulated during the last few decades, suggests that rather than separated entities, the MOS and AOS act synergically, bringing about physiological and behavioural responses. The goal of the present Research Topic will be to gather original research studies and revision papers, performed by the most authoritative research groups that have recently contributed to the broad area of sensory neurobiology. Special attention should be given to contributions addressed to the MOB and AOB cross-talk, involving current neuroanatomical techniques
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 69
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193127
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 70
    ISBN: 9782889193011
    Language: English
    Pages: 1 Online-Ressource (144 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 71
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193394
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Francisella tularensis, the causative agent of tularemia, is a paradigm among human pathogens. This Gram-negative bacterium has an intracellular lifestyle, which probably reflects an adaptation to its natural animal and protozoa reservoirs. This is one of the most infectious agents in humans and animals; only a few bacteria are needed to induce a severe infection in both types of hosts. The clinical presentation and severity of human tularemia varies according to the portal of entry of bacteria, the bacterial inoculum, the virulence of the infecting strain, and the immune response of the host. Although most infections occur after direct inoculation of bacteria through the skin (through skin wounds or bites of arthropods), pneumonia due to inhalation of infected aerosols is the most feared of the clinical forms of the disease, particularly in the context of biological threat. Two subspecies are responsible for tularemia (subsp. tularensis and subsp. holarctica), and several clades have been described for each, which might be associated with changes in disease severity in humans. Tularemia is also more severe in people with an impaired immune response. No safe vaccine is currently available for prophylaxis of tularemia in humans. On the other hand, control of proliferation of F. tularensis in wildlife is not feasible. Thus, only the anti-infective agents are used for treatment and prophylaxis of human tularemia. The standard options include aminoglycosides (gentamicin), tetracyclines (eg, doxycycline) and fluoroquinolones (eg, ciprofloxacin). The selection of acquired resistance to these antibiotics in F. tularensis, especially in the context of a biological threat, may quickly limit the therapeutic options. New prophylactic and therapeutic alternatives must be developed rapidly. The present Research Topic focuses on potential new strategies for treatment of tularemia, including the development and evaluation of new compounds having proper antibacterial activity, reducing the virulence of F. tularensis or enhancing the immune host response
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 72
    ISBN: 9782889193202
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Like in the case of drugs, gambling hijacks reward circuits in a brain which is not prepared to receive such intense stimulation. Dopamine is normally released in response to reward and uncertainty in order to allow animals to stay alive in their environment – where rewards are relatively unpredictable. In this case, behavior is regulated by environmental feedbacks, leading animals to persevere or to give up. In contrast, drugs provide a direct, intense pharmacological stimulation of the dopamine system that operates independently of environmental feedbacks, and hence causes “motivational runaways”. With respect to gambling, the confined environment experienced by gamblers favors the emergence of excitatory conditioned cues, so that positive feedbacks take over negative feedbacks. Although drugs and gambling may act differently, their abnormal activation of reward circuitry generates an underestimation of negative consequences and promotes the development of addictive/compulsive behavior. In Parkinson’s and Huntington’s disease, dopamine-related therapies may disrupt these feedbacks on dopamine signalling, potentially leading to various addictions, including pathological gambling. The goal of this Research Topic is to further our understanding of the neurobiological mechanisms underlying the development of pathological gambling. This eBook contains a cross-disciplinary collection of research and review articles, ranging in scope from animal behavioral models to human imaging studies
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 73
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192649
    Language: English
    Pages: 1 Online-Ressource (169 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Everyday we vicariously experience a range of states that we observe in other people: we may "feel" embarrassed when witnessing another making a social faux pas, or we may feel sadness when we see a loved one upset. In some cases this process appears to be implicit. For instance, observing pain in others may activate pain-related neural processes but without generating an overt feeling of pain. In other cases, people report a more literal, conscious sharing of affective or somatic states and this has sometimes been described as representing an extreme form of empathy. By contrast, there appear to be some people who are limited in their ability to vicariously experience the states of others. This may be the case in several psychiatric, neurodevelopmental, and personality disorders where deficits in interpersonal understanding are observed, such as schizophrenia, autism, and psychopathy. In recent decades, neuroscientists have paid significant attention to the understanding of the “social brain,” and the way in which neural processes govern our understanding of other people. In this Research Topic, we wish to contribute towards this understanding and ask for the submission of manuscripts focusing broadly on the neural underpinnings of vicarious experience. This may include theoretical discussion, case studies, and empirical investigation using behavioural techniques, electrophysiology, brain stimulation, and neuroimaging in both healthy and clinical populations. Of specific interest will be the neural correlates of individual differences in traits such as empathy, how we distinguish between ourselves and other people, and the sensorimotor resonant mechanisms that may allow us to put ourselves in another's shoes
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 74
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193080
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Energy metabolism is central to life and altered energy expenditure (EE) is often cited as a central mechanism responsible for development of the obese phenotype. Resting EE, EE of physical activity, cold induced thermogenesis and thermic effect of feeding add to produce total EE but can also affect each other. It is thus very important that each component be well measured. Measuring energy expenditure by indirect calorimetry is extremely simple in theory but the practice if far more difficult. Taking into account temperature in small sized animals, measuring accurately the effect of activity on EE, correcting EE for body size body composition, age sex etc… add difficulties in producing reliable data. The goal of this Research Topic was to call for the practical experience of main investigators trained to practice calorimetry in order to get their feedback and the way they deal with the various and specific problems of humans and animal calorimetry. The goal is to share the questions/solutions experienced by the contributors to inititate a “guide of the good practices” that can be periodically updated and used by all those who are and will be interested in measuring energy metabolism from the 20g mouse to the human and large farm animals
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 75
    ISBN: 9782889192731
    Language: English
    Pages: 1 Online-Ressource (196 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The recording and analysis of electrical brain activity associated with eye movements has a history of several decades. While the early attempts were primarily focused on uncovering the brain mechanisms of eye movements, more recent approaches use eye movements as markers of the ongoing brain activity to investigate perceptual and cognitive processes. This recent approach of segmenting brain activity based on eye movement behavior has several important advantages. First, the eye movement system is closely related to cognitive functions such as perception, attention and memory. This is not surprising since eye movements provide the easiest and the most accurate way to extract information from our visual environment and the eye movement system largely determines what information is selected for further processing. The eye movement-based segmentation offers a great way to study brain activity in relation to these processes. Second, on the methodological level, eye movements constitute a natural marker to segment the ongoing brain activity. This overcomes the problem of introducing artificial markers such as ones for stimulus presentation or response execution that are typical for a lab-based research. This opens possibilities to study brain activity during self-paced perceptual and cognitive behavior under naturalistic conditions such as free exploration of scenes. Third, by relating eye movement behavior to the ongoing brain activity it is possible to see how perceptual and cognitive processes unfold in time, being able to predict how brain activity eventually leads to behavior. This research topic illustrates advantages of the combined recording and analysis of eye movements and neural signals such as EEG, local field potentials and fMRI for investigation of the brain processes in humans and animals. The contributions include research papers, methodology papers and reviews demonstrating conceptual and methodological achievements in this rapidly developing field
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 76
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193493
    Language: English
    Pages: 1 Online-Ressource (194 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 77
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193646
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the 19th century, grou ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 78
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193158
    Language: English
    Pages: 1 Online-Ressource (198 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The basic nuts and bolts underlying human behavior remain mysterious from a scientific point of view. Everyday acts - naming an object, suppressing the urge to say something, or grabbing a waiter’s attention with a “cappuccino, please” - remain difficult to understand from a mechanistic standpoint. Despite these challenges, research has begun to illuminate, not only the basic processes underlying human action production, but the role of conscious processing in the control of behavior. This Research Topic, “Consciousness and the Control of Action,” is devoted to surveying and synthesizing these developments from disparate fields of study
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 79
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192885
    Language: English
    Pages: 1 Online-Ressource (133 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Neurons communicate by sending action potentials down their axons and release neurotransmitter at the synapses with target neurons in nearby or remote regions. Although we know the approximate connectivity of cortico-cortical axons in several species, this does not enable us to predict the communication dynamics. The cortico-cortical communication dynamics specify how the communication evolves in real time and cortical space ms by ms. Currently we are only beginning to appreciate this space-time dynamics from multielectrode recordings, imaging of Ca2+ transients and membrane voltage simultaneously over several areas during brain tasks, perception or preparation for behavior. The results from such experiments indeed challenge traditional ideas of cortico-cortical communications. The communication dynamics in these conditions differ somewhat from that present in steady states that are characterized as fix points or as oscillatory states (limit cycles). There are, however, realistic computational models of communications between several areas or the whole cortex, which have been able to express communication dynamics mimicking the experimentally obtained results during brain tasks, such as perception and decision making. This Research Topic issue will welcome communications in any form, experimental, theoretical, conceptual, and even better combinations of these, on real time cortico-cortical communication dynamics. The introductions must include sections of review character – helping readers outside the field to understand the context in which the contribution is placed
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 80
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193349
    Language: English
    Pages: 1 Online-Ressource (87 p.)
    Series Statement: Frontiers Research Topics
    Abstract: It is well known that the activation of the circulating renin angiotensin system is involved in cardiovascular pathology including hypertension, heart failure and is responsible for important organic changes induced by diabetes. Evidence is now available that independently of the classical system, there are local renin angiotensin systems in different organs including the heart, circulatory vessels, kidney and probably brain and that components of these local systems participate in important aspects of physiology and pathology. Of particular interest is the presence of an intracellular component-the so called intracrine renin angiotensin system, which seems related to regulation of several cellular functions. A discussion of the different aspects of this important topic is of relevance to cell biology, endocrinology, physiology and pathology and justify a comprehensive presentation to the scientific community organized by experts in their respective fields
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 81
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193134
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Aims and Scope: The Research Topic is designed to feature the latest innovative and leading-edge research, reviews and opinions on the study of complex and dynamic processes related to the mammalian immune system and cancer. All papers were meticulously selected to present our readers the multidisciplinary approach to tackle the existing challenges faced in these important fields. From high throughput experimental methodologies to computational and theoretical approaches, the articles are intended to introduce physicists, chemists, computer scientists, biologists and immunologists the idea of systems biology approach to the understanding of mammalian immune system and cancer processes. Attention was given to works that developed more effective approaches to the treatment of proinflammatory disease and cancer. The strong interdisciplinary focus will discuss biological systems at the level from a few molecules to the entire organism. Specific focus domain includes: Innate and adaptive immunity, cancer and cancer stem cell, genomic, proteomic and metabolic analysis, imaging, biophysics of immune and cancer response, computational modeling, non-linear analysis, statistical analysis, translational and disease models Types of articles: Viewpoint, commentaries, research letters, research articles, review and methodologies
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 82
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193288
    Language: English
    Pages: 1 Online-Ressource (367 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 83
    ISBN: 9782889192458
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Significant efforts over ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 84
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192526
    Language: English
    Pages: 1 Online-Ressource (118 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The problem of how humans ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 85
    ISBN: 9782889192717
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Decades of brain imaging ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 86
    ISBN: 9782889192847
    Language: English
    Pages: 1 Online-Ressource (235 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In contrast to the situation in heterotrophic organisms, plant genomes code for a significantly larger number of oxidoreductases such as thioredoxins (TRXs) and glutaredoxins (GRXs). These proteins provide a biochemical mechanism that allows the rapid and reversible activation or deactivation of protein functions in response to changing environmental conditions, as oxidative conditions caused by excessive photosynthesis. Indeed, owing to the fact that cysteines are sensitive to oxidation, TRXs and GRXs play an essential role in controlling the redox state of protein thiol groups. These redox-dependent post-translational modifications have proven to be critical for many cellular functions constituting regulatory, signalling or protective mechanisms. The articles contained in this Research Topic provide timely overviews and new insights into thiol-dependent redox regulation mechanisms with a focus on TRX- and GRX-based reduction systems in plants. The different contexts discussed take into account physiological, developmental and environmental conditions
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 87
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193424
    Language: English
    Pages: 1 Online-Ressource (129 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Exponentially increasing information on biological organisms coupled with increasing computational power in the past decade have broadened the perspective of fundamental biological research, bringing about considerable promise and unprecedented potential for practical applications in biotechnology. As one emergent discipline, synthetic biology aims to design and engineer novel biologically-based parts, devices, and systems, in addition to redesigning existing, natural biological systems. Although previously relegated to demonstration studies, more recent research in synthetic biology has focused on the rational engineering of industrial microorganisms with the potential to address many of society’s critical challenges. Within the realm of industrial microbiology, progress in the field of synthetic biology has enabled the development of, for example, new biosynthetic pathways for the production of renewable fuels and chemicals, programmable logic controls to regulate and optimize cell function, and robust microbes for the destruction of harmful environmental contaminants. Some of the exciting examples included producing anti-malarial drug, anti- cancer taxol precursor and various biofuel molecules in E. coli and yeast. In addition, these researches have also greatly enhanced our understanding of the cellular machinery and its regulation in some of the industry important microbes, laying an important foundation for further design and engineering of biological function for even greater application. For these reasons, we present here a collection of articles from the leading edge of the field of synthetic biology, with a specific focus on the development in industrial microorganisms. It is the intent of this collection to reach a wide audience whose interests and expertise spans from development of novel synthetic biology methodologies and theories (both experimental and computational) to practical applications seeking to address issues facing the world today
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 88
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192441
    Language: English
    Pages: 1 Online-Ressource (93 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism. Deregulation of the PI3K pathway has been extensively investigated in connection to cancer. Somatic or inherited mutations frequently occur in tumor suppressor genes (PTEN, TSC1/2, LKB1) and oncogenes (PIK3CA, PIK3R1, AKT) in the PI3K/mTOR pathway. The fact that the PI3K/mTOR pathway is deregulated in a large number of human malignancies, and its importance for different cellular responses, makes it an attractive drug target. Pharmacological PI3K inhibitors have played a very important role in studying cellular responses involving these enzymes. Currently, a wide range of selective PI3K inhibitors have been tested in preclinical studies and some have entered clinical trials in oncology. Rapamycin and its analogs targeting mTOR are effective in many preclinical cancer models. Although rapalogs are approved for the treatment of some cancers, their efficacy in clinical trials remains the subject of debate. Due to the complexity of the PI3K/mTOR signaling pathway, developing an effective anti-cancer therapy remains a challenge. The biggest challenge in curing cancer patients with various signaling pathway abnormalities is to target multiple components of different signal transduction pathways with mechanism-based combinatorial treatments
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 89
    ISBN: 9782889192496
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Development of powerful n ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 90
    ISBN: 9782889192700
    Language: English
    Pages: 1 Online-Ressource (259 p.)
    Series Statement: Frontiers Research Topics
    Abstract: At the core of the many debates throughout cognitive science concerning how decisions are made are the processes governing the time course of preference formation and decision. From perceptual choices, such as whether the signal on a radar screen indicates an enemy missile or a spot on a CT scan indicates a tumor, to cognitive value-based decisions, such as selecting an agreeable flatmate or deciding the guilt of a defendant, significant and everyday decisions are dynamic over time. Phenomena such as decoy effects, preference reversals and order effects are still puzzling researchers. For example, in a legal context, jurors receive discrete pieces of evidence in sequence, and must integrate these pieces together to reach a singular verdict. From a standard Bayesian viewpoint the order in which people receive the evidence should not influence their final decision, and yet order effects seem a robust empirical phenomena in many decision contexts. Current research on how decisions unfold, especially in a dynamic environment, is advancing our theoretical understanding of decision making. This Research Topic aims to review and further explore the time course of a decision - from how prior beliefs are formed to how those beliefs are used and updated over time, towards the formation of preferences and choices and post-decision processes and effects. Research literatures encompassing varied approaches to the time-scale of decisions will be brought into scope: a) Speeded decisions (and post-decision processes) that require the accumulation of noisy and possibly non-stationary perceptual evidence (e.g., randomly moving dots stimuli), within a few seconds, with or without temporal uncertainty. b) Temporally-extended, value-based decisions that integrate feedback values (e.g., gambling machines) and internally-generated decision criteria (e.g., when one switches attention, selectively, between the various aspects of several choice alternatives). c) Temporally extended, belief-based decisions that build on the integration of evidence, which interacts with the decision maker's belief system, towards the updating of the beliefs and the formation of judgments and preferences (as in the legal context). Research that emphasizes theoretical concerns (including optimality analysis) and mechanisms underlying the decision process, both neural and cognitive, is presented, as well as research that combines experimental and computational levels of analysis
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 91
    ISBN: 9782889192397
    Language: English
    Pages: 1 Online-Ressource (123 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The most biologically-inspired artificial neurons are those of the third generation, and are termed spiking neurons, as individual pulses or spikes are the means by which stimuli are communicated. In essence, a spike is a short-term change in electrical potential and is the basis of communication between biological neurons. Unlike previous generations of artificial neurons, spiking neurons operate in the temporal domain, and exploit time as a resource in their computation. In 1952, Alan Lloyd Hodgkin and Andrew Huxley produced the first model of a spiking neuron; their model describes the complex electro-chemical process that enables spikes to propagate through, and hence be communicated by, spiking neurons. Since this time, improvements in experimental procedures in neurobiology, particularly with in vivo experiments, have provided an increasingly more complex understanding of biological neurons. For example, it is now well understood that the propagation of spikes between neurons requires neurotransmitter, which is typically of limited supply. When the supply is exhausted neurons become unresponsive. The morphology of neurons, number of receptor sites, amongst many other factors, means that neurons consume the supply of neurotransmitter at different rates. This in turn produces variations over time in the responsiveness of neurons, yielding various computational capabilities. Such improvements in the understanding of the biological neuron have culminated in a wide range of different neuron models, ranging from the computationally efficient to the biologically realistic. These models enable the modelling of neural circuits found in the brain. In recent years, much of the focus in neuron modelling has moved to the study of the connectivity of spiking neural networks. Spiking neural networks provide a vehicle to understand from a computational perspective, aspects of the brain's neural circuitry. This understanding can then be used to tackle some of the historically intractable issues with artificial neurons, such as scalability and lack of variable binding. Current knowledge of feed-forward, lateral, and recurrent connectivity of spiking neurons, and the interplay between excitatory and inhibitory neurons is beginning to shed light on these issues, by improved understanding of the temporal processing capabilities and synchronous behaviour of biological neurons. This research topic aims to amalgamate current research aimed at tackling these phenomena
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 92
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193240
    Language: English
    Pages: 1 Online-Ressource (84 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Plants are made up of a large number of distinct cell types that originate from a single fertilized egg cell. How the diversity of cell types arise in appropriate places is one of the most fascinating and attractive research areas of plant biology. During the past several decades, due to the development of new molecular techniques and tools, advances in optical microscopy, and availability of whole genome information and mutants in the model plant Arabidopsis and other plants, great advances have been made in understanding the mechanisms involved in cell fate determination in plants. Multiple mechanisms are used to generate cellular diversity. Asymmetric cell division is one of the primary mechanisms. As an example, asymmetric cell division enables one stem cell to generate a stem cell daughter and a daughter with a distinct identity. Initially equivalent cells can also differentiate to generate different cell types. This mechanism has been clearly demonstrated in the formation of multiple cell types during epidermis development in the shoot and root. Cell fate determination is influenced by both intrinsic factors, i.e, developmental regulators, as well as extrinsic signals, i.e., environmental stimuli. By using model systems like stomata, trichome, root hair and shoot and root apical meristem cells, ligands, receptors and transcription factors have been found to regulate cell fate determination. However, the details of signaling cassettes responsible for cell fate determination remain largely unknown. Plants are made up of a large number of distinct cell types that originate from a single fertilized egg cell. How the diversity of cell types arise in appropriate places is one of the most fascinating and attractive research areas of plant biology. During the past several decades, due to the development of new molecular techniques and tools, advances in optical microscopy, and availability of whole genome information and mutants in the model plant Arabidopsis and other plants, great advances have been made in understanding the mechanisms involved in cell fate determination in plants. This research topic contains 12 collected articles, including 2 Opinion Articles, 5 Reviews, 4 Mini Reviews, and 1 Original Research Article. Hopefully, these articles will expand our understanding of the regulation of cell fate determination in plants
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 93
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193264
    Language: English
    Pages: 1 Online-Ressource (129 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Members of the protein ki ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 94
    ISBN: 9782889193219
    Language: English
    Pages: 1 Online-Ressource (119 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The chlamydiae are Gram-negative, obligate intracellular bacteria with a complex developmental cycle comprising a metabolically less-active, infectious stage, the elementary body (EB), and a metabolically more active stage, the reticulate body (RB). They are responsible for many acute and chronic diseases in humans and animals. In order to play a causative role in chronic diseases, chlamydiae would need to persist and to re-activate within infected cells/tissues for extended periods of time. Persistence in vitro is defined as viable but non-cultivable chlamydiae involving morphologically enlarged, aberrant, and nondividing RBs, termed aberrant bodies (AB). In vitro, alterations of the normal developmental cycle of chlamydiae can be induced by the addition of Interferon-? (IFN-?), tumor necrosis factor-a (TNF-a) and penicillin G exposure as well as amino acid or iron deprivation, monocyte infection and co-infection with viruses. In vivo, key questions include whether or not ABs occur in infected patients and animals and whether such ABs can contribute to prolonged, chronic inflammation, fibrosis, and scarring through continuing stimulation of the host immune system known from diseases such as trachoma, pelvic inflammatory disease, reactive arthritis and atherosclerosis. To date, the direct causal role in the pathogenesis of chlamydial infection and persistence in vivo has been questioned since there was no tractable animal model of chlamydial persistence so far. A very recent study was able to establish an experimental animal model of in vivo persistence, when C. muridarum vaginally-infected mice were gavaged with amoxicillin. Amoxicillin treatment induced C. muridarum to enter the persistent state in vivo. Recent in vivo data from patients indicate that viable but non-infectious developmental stages are present in the genital tract of chronically-infected women and that the gastrointestinal tract might be a reservoir for persistent chlamydial infections at other sites
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 95
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192946
    Language: English
    Pages: 1 Online-Ressource (102 p.)
    Series Statement: Frontiers Research Topics
    Abstract: With the advent of recombinant DNA technology, expressing heterologous proteins in microorganisms rapidly became the method of choice for their production at laboratory and industrial scale. Bacteria, yeasts and other hosts can be grown to high biomass levels efficiently and inexpensively. Obtaining high yields of recombinant proteins from this material was only feasible thanks to constant research on microbial genetics and physiology that led to novel strains, plasmids and cultivation strategies. Despite the spectacular expansion of the field, there is still much room for progress. Improving the levels of expression and the solubility of a recombinant protein can be quite challenging. Accumulation of the product in the cell can lead to stress responses which affect cell growth. Buildup of insoluble and biologically inactive aggregates (inclusion bodies) lowers the yield of production. This is particularly true for obtaining membrane proteins or high-molecular weight and multi-domain proteins. Also, obtaining eukaryotic proteins in a prokaryotic background (for example, plant or animal proteins in bacteria) results in a product that lack post-translational modifications, often required for functionality. Changing to a eukaryotic host (yeasts or filamentous fungi) may not be a proper solution since the pattern of sugar modifications is different than in higher eukaryotes. Still, many advances in the last couple of decades have provided to researchers a wide variety of strategies to maximize the production of their recombinant protein of choice. Everything starts with the careful selection of the host. Be it bacteria or yeast, a broad list of strains is available for overcoming codon use bias, incorrect disulfide bond formation, protein toxicity and lack of post-translational modifications. Also, a huge catalog of plasmids allows choosing for different fusion partners for improving solubility, protein secretion, chaperone co-expression, antibiotic resistance and promoter strength. Next, controlling culture conditions like temperature, inducer and media composition can bolster recombinant protein production. With this Research Topic, we aim to provide an encyclopedic account of the existing approaches to the expression of recombinant proteins in microorganisms, highlight recent discoveries and analyze the future prospects of this exciting and ever-growing field
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 96
    ISBN: 9782889193547
    Language: English
    Pages: 1 Online-Ressource (99 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There has been an ongoing ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 97
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193530
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The 2nd International Conference "Genetics of aging and longevity" took place 22-25 April, 2012 in the main building of Russian Academy of Sciences, Moscow, Russia. Top gerontologists and geneticists from 25 countries around the world discussed the current problems in many areas related to the genetics of longevity and mechanisms of aging. This Research Topic is aimed to provide a collection of articles based on the talks, reports and experimental outcomes related to the topics of the conference: "Epigenetic Changes Associated with Longevity", "Hormones and Aging", "Proximal and Cellular Mechanisms of Aging", "Nutrient Signaling, Stress Resistance and Longevity", "Identifying Longevity Genes by Mutational, QTL and Association Mapping", "Fundamental Biological Processes Central to Aging", "Interventions to Extend Lifespan and Promote Healthy Aging", "Longevity: Meta-Analysis and Informatics Approaches". Participants of the Conference submitted 20 papers belonging to Original Research Papers, Review Articles (Including Mini Reviews), Opinion and Perspective Papers. All of the submitted manuscripts were peer-reviewed by excellent Frontiers Review Editors and prepared for publication by highly efficient Frontiers team, and it is a pleasure to thank them all for their work and dedication
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 98
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192588
    Language: English
    Pages: 1 Online-Ressource (199 p.)
    Series Statement: Frontiers Research Topics
    Abstract: For decades, pathogenic Yersinia have served as an inventive model organism for researchers seeking to understand the complexities of bacteria-host cell interactions. In fact, seminal studies on Yersinia virulence mechanisms contributed to the emergence and recognition of the research field - cellular microbiology. Researching Yersinia infection biology continues to identify and define fascinating virulence and survival mechanisms that advance and expand existing perceptions of bacterial-host encounters. This also includes research that defines how the pathogenic Yersiniae respond to diverse physicochemical stimuli to spatially and temporally control this armory of customized virulence and survival factors. Yet additional research demonstrates how the application of powerful whole genomic-based methodologies can open new frontiers that further facilitate understanding of bacterial evolution and pathogenicity. This Research Topic is therefore focused on presenting and summarizing new developments in Yersinia patho-physiology through highlighting cutting- edge studies on the Yersinia-host cell interaction and the network of regulatory control mechanisms that define this outcome
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 99
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889193479
    Language: English
    Pages: 1 Online-Ressource (207 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Echolocation has evolved in different groups of animals, from bats and cetaceans to birds and humans, and enables localization and tracking of objects in a dynamic environment, where light levels may be very low or absent. Nature has shaped echolocation, an active sense that engages audiomotor feedback systems, which operates in diverse environments and situations. Echolocation production and perception vary across species, and signals are often adapted to the environment and task. In the last several decades, researchers have been studying the echolocation behavior of animals, both in the air and underwater, using different methodologies and perspectives. The result of these studies has led to rich knowledge on sound production mechanisms, directionality of the sound beam, signal design, echo reception and perception. Active control over echolocation signal production and the mechanisms for echo processing ultimately provide animals with an echoic scene or image of their surroundings. Sonar signal features directly influence the information available for the echolocating animal to perceive images of its environment. In many echolocating animals, the information processed through echoes elicits a reaction in motor systems, including adjustments in subsequent echolocation signals. We are interested in understanding how echolocating animals deal with different environments (e.g. clutter, light levels), tasks, distance to targets or objects, different prey types or other food sources, presence of conspecifics or certain predators, ambient and anthropogenic noise. In recent years, some researchers have presented new data on the origins of echolocation, which can provide a hint of its evolution. Theoreticians have addressed several issues that bear on echolocation systems, such as frequency or time resolution, target localization and beam-forming mechanisms. In this Research Topic we compiled recent work that elucidates how echolocation – from sound production, through echolocation signals to perception- has been shaped by nature functioning in different environments and situations. We strongly encouraged comparative approaches that would deepen our understanding of the processes comprising this active sense
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 100
    ISBN: 9782889193301
    Language: English
    Pages: 1 Online-Ressource (219 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Orexin/hypocretin neurope ...
    Note: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...