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  • 2015-2019  (1.024)
  • 2015  (1.024)
  • Ann Arbor, Michigan : ProQuest  (682)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (342)
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  • 2015-2019  (1.024)
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  • 1
    Online-Ressource
    Online-Ressource
    Englisch lernen in Betrieben (2015)
    Tübingen : Narr Francke Attempto | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783823379782
    Sprache: Deutsch
    Seiten: 1 Online-Ressource (209 pages)
    DDC: 305.24
    Schlagwort(e): Englisch ; Fremdsprache ; Erwachsenenbildung ; Betriebliche Bildungsarbeit ; Fremdsprache ; Erwachsenenbildung ; Betriebliche Bildungsarbeit
    Anmerkung: Description based on publisher supplied metadata and other sources
    URN: urn:nbn:de:101:1-2018052215104
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    HeBIS
  • 2
    Online-Ressource
    Online-Ressource
    Africa : an encyclopedia of culture and society (2015)
    Santa Barbara, California : ABC-CLIO, an imprint of ABC-CLIO, LLC | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781598846669
    Sprache: Englisch
    Seiten: 1 Online-Ressource (xxxii, 1366 Seiten) , Illustrationen, Karten
    Paralleltitel: Erscheint auch als Africa
    RVK:
    LB 12465
    Schlagwort(e): Kultur ; Gesellschaft ; Encyclopedias ; Electronic books ; Afrika ; Africa Encyclopedias Civilization ; Africa Encyclopedias ; Enzyklopädie
    Kurzfassung: A3239C_9781598846669_Vol_1 -- Cover page -- Halftitle page -- Title page -- Copyright page -- Contents -- Preface -- Acknowledgments -- Introduction -- Chronology -- Algeria -- Angola -- Benin, Republic of -- Botswana -- Burkina Faso -- Burundi, Republic of -- Cameroon, Republic of (République du Cameroun) -- Cape Verde -- Central African Republic -- Chad -- Comoros, Federal Islamic Republic of the (The Union of the Comoros/Union des Comores) -- Congo, Democratic Republic of the (DRC) -- Congo, Republic of -- Côte d'Ivoire, République de -- Djibouti -- A3239C_9781598846669_Vol_2 -- Cover page -- Halftitle page -- Title page -- Copyright page -- Contents -- Egypt, Arab Republic of (Gumhuriyyat Mis·ral-ʿArabiyyah) -- Equatorial Guinea -- Eritrea -- Ethiopia -- Gabon, Republic of -- The Gambia -- Ghana -- Guinea -- Guinea-Bissau -- Kenya -- Lesotho -- Liberia -- Libya -- Madagascar -- Malawi -- Mali -- Mauritania -- Mauritius -- Morocco -- Mozambique -- A3239C_9781598846669_Vol_3 -- Cover page -- Halftitle page -- Title page -- Copyright page -- Contents -- Namibia -- Niger -- Nigeria -- Rwanda -- São Tomé and Príncipe -- Senegal -- Seychelles, Republic of (or Seychelles Islands) -- Sierra Leone -- Somalia -- South Africa -- South Sudan, Republic of -- Sudan, Democratic Republic of(Jamburyat es-Sudan Al Democratia) -- Swaziland -- Tanzania -- Togo (Togolese Republic) -- Tunisia -- Uganda -- Zambia -- Zimbabwe -- General Bibliography -- Index
    Anmerkung: Literaturverzeichnis Seite 1329-1330 , Der Volltext enthält Band 1-3 , Volume 1: Algeria– Djibouti , Volume 2: Egypt– Mozambique , Volume 3: Namibia– Zimbabwe , Online-Ausg.
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  • 3
    Online-Ressource
    Online-Ressource
    The unfolded protein response in virus infections (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889193974
    Sprache: Englisch
    Seiten: 1 Online-Ressource (129 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as neurodegenerative diseases, cystic fibrosis, diabetes and cancer. It has recently emerged that virus infections can trigger the UPR but the relationship between virus infections and host UPR is intriguing. On one hand, UPR is harmful to the virus and virus has developed means to subvert the UPR. On the other hand, virus exploits the host UPR to assist in its own infection, gene expression, establishment of persistence, reactivation from latency and to evade the immune response. When this delicate balance of virus-host UPR interaction is broken down, it may cause diseases. This is particularly challenging for viruses that establish a chronic infection to maintain this balance. Each virus interacts with the host UPR in a different way to suit their life style and how the virus interacts with the host UPR can define the characteristic of a particular virus infection. Understanding how a particular virus interacts with the host UPR may pave the way to the design of a new class of anti-viral that targets this particular pathway to skew the response towards anti-virus. This knowledge can also be translated into the clinics to help re-design oncolytic virotherapy and gene therapy. In this research topic we aimed to compile a collection of focused review articles, original research articles, commentary, opinion, hypothesis and methods to highlight the current advances in this burgeoning area of research, in an attempt to provide an in-depth understanding of how viruses interact with the host UPR, which may be beneficial to the future combat of viral and human diseases
    Anmerkung: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 4
    Online-Ressource
    Online-Ressource
    The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889195435
    Sprache: Englisch
    Seiten: 1 Online-Ressource (140 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common form of lung cancer, accounting for approximately 87% of cases. Systemic chemotherapies have been used to treat metastatic NSCLC for decades, but the improvements of outcomes have reached a plateau. Recent advances in understanding signalling pathways for malignant cells, their interconections,the importance of various receptors and biomarkers and the interplay between various oncogenes have led to the development of targeted treatments that are improving both efficacy and safety of the treatments. Knowledge about the advantages of treatments with the targeted agents in metastatic NSCLC is growing rapidly. Combining various targeted agents or sequencing them properly will be important in the era of personalised medicine and overcoming development of the resistence to various targeted agents will be challenging. The importance of a team work,from the diagnosis through various treatments, to supportive care, from the interventional radiologists, pneumologists or surgeons, who have to obtain a satisfactory tumor tissue specimen, to pathologists, radiation and medical oncologists, to supportive care specialists, will be described in our publications. We will cover completely present and future approaches to personalised medicine in this rapidly evolving field of metastatic NSCLC
    Anmerkung: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 5
    Online-Ressource
    Online-Ressource
    Transcriptional Regulation in Cancers and Metabolic Diseases (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889197125
    Sprache: Englisch
    Seiten: 1 Online-Ressource (98 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, the most famous tumor suppressor. The p53 mutations either results in loss of function, or acting as dominant negative for wild-type protein, or ‘gain of function’ specifically promoting cancer survival. The gain of function is achieved by shifting p53 binding partner proteins, or changed genomic binding landscape leading to a cancer-promoting transcriptome. Another example of genetic change of TF causing malignancy is the AML-ETO fusion protein in the human t(8;21)-leukemia. The fusion protein is an active TF, and more interestingly, new studies link the disease causing role of AML-ETO to the unique transcriptome in the hematopoietic stem cells. Nuclear receptors (NR) are a group of ligand-dependent TFs governing the expression of genes involved in a broad range of reproductive, developmental and metabolic programs. Genetic changes and epigenetic modifications of NRs lead to cancers and metabolic diseases. Androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR) are well studied NRs in prostate, breast and endometrial cancers. The development in sequencing technology and computational genomics enable us to investigate the transcription programs of these master TFs in an unprecedented level. This Research Topic aims to present the most up-to-date progress in the field of transcription regulation in cancers and metabolic diseases
    Anmerkung: English
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    MPI Ethno. Forsch.
  • 6
    Online-Ressource
    Online-Ressource
    Towards an embodied science of intersubjectivity: Widening the scope of social understanding research (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889195299
    Sprache: Englisch
    Seiten: 1 Online-Ressource (413 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: An important amount of research effort in psychology and neuroscience over the past decades has focused on the problem of social cognition. This problem is understood as how we figure out other minds, relying only on indirect manifestations of other people's intentional states, which are assumed to be hidden, private and internal. Research on this question has mostly investigated how individual cognitive mechanisms achieve this task. A shift in the internalist assumptions regarding intentional states has expanded the research focus with hypotheses that explore the role of interactive phenomena and interpersonal histories and their implications for understanding individual cognitive processes. This interactive expansion of the conceptual and methodological toolkit for investigating social cognition, we now propose, can be followed by an expansion into wider and deeply-related research questions, beyond (but including) that of social cognition narrowly construed. Our social lives are populated by different kinds of cognitive and affective phenomena that are related to but not exhausted by the question of how we figure out other minds. These phenomena include acting and perceiving together, verbal and non-verbal engagement, experiences of (dis-)connection, management of relations in a group, joint meaning-making, intimacy, trust, conflict, negotiation, asymmetric relations, material mediation of social interaction, collective action, contextual engagement with socio-cultural norms, structures and roles, etc. These phenomena are often characterized by a strong participation by the cognitive agent in contrast with the spectatorial stance typical of social cognition research. We use the broader notion of embodied intersubjectivity to refer to this wider set of phenomena. This Research Topic aims to investigate relations between these different issues, to help lay strong foundations for a science of intersubjectivity – the social mind writ large. To contribute to this goal, we encouraged contributions in psychology, neuroscience, psychopathology, philosophy, and cognitive science that address this wider scope of intersubjectivity by extending the range of explanatory factors from purely individual to interactive, from observational to participatory
    Anmerkung: English
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    MPI Ethno. Forsch.
  • 7
    Online-Ressource
    Online-Ressource
    What makes written words so special to the brain (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889193790
    Sprache: Englisch
    Seiten: 1 Online-Ressource (267 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Reading is an integral part of life in today's information-driven societies. Since the pioneering work of Dejerine on "word blindness" in brain-lesioned patients, the literature has increased exponentially, from neuropsychological case reports to mechanistic accounts of word processing at the behavioural, neurofunctional and computational levels, tapping into diverse aspects of visual word processing. These studies have revealed some exciting findings about visual word processing, including how the brain learns to read, how changes in literacy impact upon word processing strategies, and whether word processing mechanisms vary across different alphabetic, logographic or artificial writing systems. Other studies have attempted to characterise typical and atypical word processes in special populations in order to explain why dyslexic brains struggle with words, how multilingualism changes the way our brains see words, and what the exact developmental signatures are that would shape the acquisition of reading skills. Exciting new insights have also emerged from recent studies that have investigated word stimuli at the system/network level, by looking for instance, at how the reading system interacts with other cognitive systems in a context-dependent fashion, how visual language stimuli are integrated into the speech processing streams, how both left and right hemispheres cooperate and interact during word processing, and what the exact contributions of subcortical and cerebellar regions to reading are. The contributions to this Research Topic highlight the latest findings regarding the different issues mentioned above, particularly how these findings can explain or model the different processes, mechanisms, pathways or cognitive strategies by which the human brain sees words. The introductory editorial, summarising the contributions included here, highlights how varieties of behavioural tests and neuroimaging techniques can be used to investigate word processing mechanisms across different alphabetic and logographic writing systems
    Anmerkung: English
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  • 8
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    Online-Ressource
    Type I Interferon in Human Autoimmunity (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889193400
    Sprache: Englisch
    Seiten: 1 Online-Ressource (87 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response against self antigens. Many investigators have focused on the role type I interferons play in autoimmune disease. This fascinating and rapidly growing body of literature encompasses many different autoimmune diseases, including systemic lupus erythematosus, type I diabetes, multiple sclerosis, and others. In this Research Topic, we provide a comprehensive overview of the various roles type I interferons play in autoimmune diseases, with a focus on human immunology
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  • 9
    Online-Ressource
    Online-Ressource
    The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889194452
    Sprache: Englisch
    Seiten: 1 Online-Ressource (160 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system
    Anmerkung: English
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    MPI Ethno. Forsch.
  • 10
    Online-Ressource
    Online-Ressource
    Dynamics of cyclic nucleotide signaling in neurons (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889196463
    Sprache: Englisch
    Seiten: 1 Online-Ressource (92 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons
    Anmerkung: English
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    MPI Ethno. Forsch.
  • 11
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    Online-Ressource
    The Emerging Discipline of Quantitative Systems Pharmacology (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889196425
    Sprache: Englisch
    Seiten: 1 Online-Ressource (97 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In 2011, the National Ins ...
    Anmerkung: English
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  • 12
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    Secretion of Cytokines and Chemokines by Innate Immune Cells (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889195503
    Sprache: Englisch
    Seiten: 1 Online-Ressource (134 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release
    Anmerkung: English
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  • 13
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    Online-Ressource
    Recent Discoveries in Evolutionary and Genomic Microbiology (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889196173
    Sprache: Englisch
    Seiten: 1 Online-Ressource (99 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: This collection represents certain discoveries that were made in evolutionary and genomic microbiology during the recent ten years. We attempted to shed light on topical issues of microbial evolution and microbiome biology. In our eyes, these articles are of an excellent quality and may be helpful both for casual readers and for specialists in the field
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  • 14
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    Regulatory RNAs in the Nervous System (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889194834
    Sprache: Englisch
    Seiten: 1 Online-Ressource (344 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Until about a decade ago, ...
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  • 15
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    Psychological perspectives on expertise (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889195206
    Sprache: Englisch
    Seiten: 1 Online-Ressource (240 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Experts are persons who are very knowledgeable about or skillful in a particular area. The aim of this Research Topic is to advance knowledge in the understanding of the phenomenon of expertise by putting together different lines of research that directly or indirectly study expertise. Herbert Simon’s expertise studies initiated two lines of research. One is interested in elucidating the cognitive processes underlying expertise, and the other investigates how expertise develops. These lines of research started with studies comparing experts and novices in chess, and then they extended to numerous areas of expertise such as music, medical diagnosis, sports, arts and sciences. In the field of judgment and decision making researchers investigate the quality of judgments and decisions of experts in different professions (e.g., clinical psychologists, medical practitioners, judges, meteorologists, stock brokers). Those lines of research explicitly investigate the topic of expertise, but there are other research areas that make a substantial contribution to understanding expertise. Scholars in language acquisition and in face perception, for example, investigate cognitive processes and development of expertise in areas in which almost everyone becomes an expert. Furthermore, skill acquisition research informs in detail about short term cognitive changes that may be important to understand how expertise develops. We are interested in original research that advances knowledge in the understanding of decision making, cognitive processes and development of expertise in sports, intellectual games, arts, scientific disciplines and professions, as well as expertise in cognitive abilities such as perception, memory, attention, language and imagery. We are also interested in theoretical articles in any of these areas, articles that describe computational or mathematical models of expertise, and articles offering a framework that would guide expertise research. Articles that offer integrative approaches of some of the areas described above are strongly encouraged. The goal of this Research Topic is to produce a hallmark piece of work in the field of expertise, which complements and does not overlap with the “Neural implementations of expertise” Research Topic in Frontiers in Human Neuroscience
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  • 16
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    Recent advances and the future generation of neuroinformatics infrastructure (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889196777
    Sprache: Englisch
    Seiten: 1 Online-Ressource (388 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The huge volume of multi-modal neuroimaging data across different neuroscience communities has posed a daunting challenge to traditional methods of data sharing, data archiving, data processing and data analysis. Neuroinformatics plays a crucial role in creating advanced methodologies and tools for the handling of varied and heterogeneous datasets in order to better understand the structure and function of the brain. These tools and methodologies not only enhance data collection, analysis, integration, interpretation, modeling, and dissemination of data, but also promote data sharing and collaboration. This Neuroinformatics Research Topic aims to summarize the state-of-art of the current achievements and explores the directions for the future generation of neuroinformatics infrastructure. The publications present solutions for data archiving, data processing and workflow, data mining, and system integration methodologies. Some of the systems presented are large in scale, geographically distributed, and already have a well-established user community. Some discuss opportunities and methodologies that facilitate large-scale parallel data processing tasks under a heterogeneous computational environment. We wish to stimulate on-going discussions at the level of the neuroinformatics infrastructure including the common challenges, new technologies of maximum benefit, key features of next generation infrastructure, etc. We have asked leading research groups from different research areas of neuroscience/neuroimaging to provide their thoughts on the development of a state of the art and highly-efficient neuroinformatics infrastructure. Such discussions will inspire and help guide the development of a state of the art, highly-efficient neuroinformatics infrastructure
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    MPI Ethno. Forsch.
  • 17
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    The role of arginase in endothelial dysfunction (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889194407
    Sprache: Englisch
    Seiten: 1 Online-Ressource (115 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction
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    MPI Ethno. Forsch.
  • 18
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    Progress in Physical activity and Exercise and Affective and Anxiety Disorders: Translational Studies, Perspectives and Future Directions (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889194711
    Sprache: Englisch
    Seiten: 1 Online-Ressource (78 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Physical activity and exercise were receiving a great attention as a strategy of prevention and treatment of affective and some anxiety disorders. Many studies have showed the efficacy of exercise in major depression and at depressed episode of bipolar patients, as well as, some authors shows the benefits of exercise in some anxiety disorders like Generalized Anxiety Disorder and Panic. Despite their efficacy, little is known concerning the main mechanisms related to the antidepressant and anxiolytic effects of exercise. Several studies in an animal model using Neurotrophic Factors, Oxidative Stress, Immunologic response and other biological markers reveal promising results. However, few studies were conducted in clinical samples. Additional to the antidepressant and anxiolytic effects, exercise appears improve QoL in major depressed, bipolar and anxiety patients. Theoretically, this increase may be associated with cognitive improvements, improvements at sleep quality, physical functioning, as well as other psychological issues as self-esteem, self-concept, and general well-being. The propose of this topic is to address the novelty and most recent research, related to antidepressant and anxiolytic effects of physical activity and exercise in patients with affective and anxiety disorders, as well as the issues associated with QoL improvement.The topic is looking for: – Clinical trials using exercise and physical activity as a treatment affective and anxiety disorders. – Studies investigating the optimal prescription factors (dose, volume, intensity, setting, frequency) associated with antidepressant and anxiolytic effects of physical activity and exercise for affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning the mechanisms of antidepressant and anxiolytic effects of physical activity and exercise in affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning other benefits of physical activity and exercise like : cognition, weight gain prevention and QoL in affective and anxiety disorder patients. – Translational research. – Studies of cost-efficacy analysis
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  • 19
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    Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889192793
    Sprache: Englisch
    Seiten: 1 Online-Ressource (163 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity
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    The metabolic challenges of immune cells in health and disease (2015)
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    ISBN: 9782889196227
    Sprache: Englisch
    Seiten: 1 Online-Ressource (80 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism
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    Language and Cognition (2015)
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    ISBN: 9782889196272
    Sprache: Englisch
    Seiten: 1 Online-Ressource (125 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Interaction between language and cognition remains an unsolved scientific problem. What are the differences in neural mechanisms of language and cognition? Why do children acquire language by the age of six, while taking a lifetime to acquire cognition? What is the role of language and cognition in thinking? Is abstract cognition possible without language? Is language just a communication device, or is it fundamental in developing thoughts? Why are there no animals with human thinking but without human language? Combinations even among 100 words and 100 objects (multiple words can represent multiple objects) exceed the number of all the particles in the Universe, and it seems that no amount of experience would suffice to learn these associations. How does human brain overcome this difficulty?
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    Lipid Signaling in T Cell Development and Function (2015)
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    ISBN: 9782889196975
    Sprache: Englisch
    Seiten: 1 Online-Ressource (142 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas
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    Madness and Creativity: Yes, No or Maybe? (2015)
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    ISBN: 9782889196708
    Sprache: Englisch
    Seiten: 1 Online-Ressource (85 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The pervasive idea that m ...
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    M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease (2015)
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    ISBN: 9782889194995
    Sprache: Englisch
    Seiten: 1 Online-Ressource (280 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Macrophages have unique a ...
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    Leading people - managing organizations: Contemporary public health leadership (2015)
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    ISBN: 9782889197262
    Sprache: Englisch
    Seiten: 1 Online-Ressource (82 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In this Research Topic, w ...
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    Learning a non-native language in a naturalistic environment: Insights from behavioural and neuroimaging research (2015)
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    ISBN: 9782889196395
    Sprache: Englisch
    Seiten: 1 Online-Ressource (150 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: It is largely accepted in the relevant literature that successful learning of one or more non-native languages is affected by a number of factors that are independent of the target language(s) per se; these factors include the age of acquisition (AoA) of the target language(s), the type and amount of formal instruction the learners have received, as well as the amount of language use that the learners demonstrate. Recent experimental evidence suggests that one crucial factor for efficient native-like performance in the non-native language is the amount of naturalistic exposure, or immersion, that the learners receive to that language. This can be broadly defined as the degree to which language learners use their non-native language outside the classroom and for their day-to-day activities, and usually presupposes that the learners live in an environment where their non-native language is exclusively or mostly used. Existing literature has suggested that linguistic immersion can be beneficial for lexical and semantic acquisition in a non-native language, as well as for non-native morphological and syntactic processing. More recent evidence has also suggested that naturalistic learning of a non-native language can also have an impact on the patterns of brain activity underlying language processing, as well as on the structure of brain regions that are involved, expressed as changes in the grey matter structure. This Research Topic brings together studies on the effects of learning and speaking a non-native language in a naturalistic environment. These include more efficient or “native-like” processing in behavioural tasks tapping on language (lexicon, morphology, syntax), as well as changes in the brain structure and function, as revealed by neuroimaging studies
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    Podocyte Pathology and Nephropathy (2015)
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    ISBN: 9782889197101
    Sprache: Englisch
    Seiten: 1 Online-Ressource (96 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and ARBs on the progression of nephropathy, the emergence of new biomarkers such as Cystatin and the role of cytokines, inflammatory molecules and adhesion molecules. Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions. Presented in this e-book articles highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process
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    Platelets as immune cells in physiology and immunopathology (2015)
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    ISBN: 9782889197408
    Sprache: Englisch
    Seiten: 1 Online-Ressource (111 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Are platelets cells? (Not ...
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  • 29
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    Photonic Integration and Photonics-Electronics Convergence on Silicon Platform (2015)
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    ISBN: 9782889196937
    Sprache: Englisch
    Seiten: 1 Online-Ressource (109 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Silicon photonics technology, which has the DNA of silicon electronics technology, promises to provide a compact photonic integration platform with high integration density, mass-producibility, and excellent cost performance. This technology has been used to develop and to integrate various photonic functions on silicon substrate. Moreover, photonics-electronics convergence based on silicon substrate is now being pursued. Thanks to these features, silicon photonics will have the potential to be a superior technology used in the construction of energy-efficient cost-effective apparatuses for various applications, such as communications, information processing, and sensing. Considering the material characteristics of silicon and difficulties in microfabrication technology, however, silicon by itself is not necessarily an ideal material. For example, silicon is not suitable for light emitting devices because it is an indirect transition material. The resolution and dynamic range of silicon-based interference devices, such as wavelength filters, are significantly limited by fabrication errors in microfabrication processes. For further performance improvement, therefore, various assisting materials, such as indium-phosphide, silicon-nitride, germanium-tin, are now being imported into silicon photonics by using various heterogeneous integration technologies, such as low-temperature film deposition and wafer/die bonding. These assisting materials and heterogeneous integration technologies would also expand the application field of silicon photonics technology. Fortunately, silicon photonics technology has superior flexibility and robustness for heterogeneous integration. Moreover, along with photonic functions, silicon photonics technology has an ability of integration of electronic functions. In other words, we are on the verge of obtaining an ultimate technology that can integrate all photonic and electronic functions on a single Si chip. This e-Book aims at covering recent developments of the silicon photonic platform and novel functionalities with heterogeneous material integrations on this platform
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    The Origin of the Plasma Cell Heterogeneity (2015)
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    Sprache: Englisch
    Seiten: 1 Online-Ressource (80 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases
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    Olfactory subsystems in mammals: morphology, genetic and evolution (2015)
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    ISBN: 9782889195541
    Sprache: Englisch
    Seiten: 1 Online-Ressource (75 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The nasal cavity and the elements it comprises are lined by mucosa. This mucosa contains olfactory sensory neurons, which are organized into four different territories: main olfactory epithelium, septal organ, vomeronasal epithelium and ganglion of Grünemberg. From a morphological point of view, these territories could initially be considered as isolated olfactory subsystems, which - as a whole or independently - have been addressed in the contributions enclosed in this Topic
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    Olfactory memory networks: from emotional learning to social behaviors (2015)
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    ISBN: 9782889194865
    Sprache: Englisch
    Seiten: 1 Online-Ressource (288 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Odors are powerful stimuli that can evoke emotional states, and support learning and memory. Decades of research have indicated that the neural basis for this strong "odor-emotional memory" connection is due to the uniqueness of the anatomy of the olfactory pathways. Indeed, unlike the other sensory systems, the sense of smell does not pass through the thalamus to be routed to the cortex. Rather, odor information is relayed directly to the limbic system, a brain region typically associated with memory and emotional processes. This provides olfaction with a unique and potent power to influence mood, acquisition of new information, and use of information in many different contexts including social interactions. Indeed, olfaction is crucially involved in behaviors essential for survival of the individual and species, including identification of predators, recognition of individuals for procreation or social hierarchy, location of food, as well as attachment between mating pairs and infant-caretaker dyads. Importantly, odors are sampled through sniffing behavior. This active sensing plays an important role in exploratory behaviors observed in the different contexts mentioned above. Odors are also critical for learning and memory about events and places and constitute efficient retrieval cues for the recall of emotional episodic memories. This broad role for odors appears highly preserved across species. In addition, the consistent early developmental emergence of olfactory function across diverse species also provides a unique window of opportunity for analysis of myriad behavioral systems from rodents to nonhuman primates and humans. This, when combined with the relatively conserved organization of the olfactory system in mammals, provides a powerful framework to explore how complex behaviors can be modulated by odors to produce adaptive responses, and to investigate the underlying neural networks. The present research topic brings together cutting edge research on diverse species and developmental stages, highlighting convergence and divergence between humans and animals to facilitate translational research
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    Physiology and Pathophysiology of Musculoskeletal Aging (2015)
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    ISBN: 9782889193905
    Sprache: Englisch
    Seiten: 1 Online-Ressource (87 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing
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    Pathophysiology and epidemiology of virus-induced asthma (2015)
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    ISBN: 9782889194100
    Sprache: Englisch
    Seiten: 1 Online-Ressource (99 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases
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    The Ischemic Penumbra: Still the Target for Stroke Therapies? (2015)
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    ISBN: 9782889196357
    Sprache: Englisch
    Seiten: 1 Online-Ressource (69 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The ischemic penumbra was initially defined by Symon, Lassen and colleagues in the 1970s as an area of brain tissue with inadequate blood flow to maintain electric activity of neurons but adequate blood flow to preserve the function of the ion channels. This area of tissue, receiving enough blood to survive but not enough to function, often surrounds or abuts the irreversibly damaged core in ischemic stroke. It was shown that if blood flow could be restored to this area of marginal perfusion, the tissue could survive and function again, and growth of the core could be prevented. Based on seminal PET studies, penumbra or "penumbral tissue" eventually took on a subtly different meaning - the area of brain that is destined to progress to infarct unless blood flow is restored within a particular time window. The penumbra thus became the target for all acute stroke interventions - to preserve viability of the tissue and restore function. New imaging techniques, including diffusion and perfusion MRI and CT perfusion, were developed to rapidly identify individuals with penumbra, who were thought to be the best candidates for aggressive interventions to restore blood flow, particularly beyond the licensed time-window for IV thrombolysis. However, most clinical trials have failed to establish the usefulness of identifying candidates for treatment in this way using pre-specified protocols and primary endpoints. These trials have used different and sometimes unvalidated thresholds of hypoperfusion as well as irreversible infarct and various definitions of significant penumbra (or mismatch between irreversible infarct and hypoperfused, but salvageable tissue), and reanalysis of their data using more refined image processing showed post-hoc positivity. They have also evaluated outcome in a variety of ways, with few studies measuring the direct effect of restoring blood flow on the function of the penumbral tissue. Therefore, important remaining questions include how to define, characterize, and image the penumbra in acute stroke to achieve the greatest reliability and validity for what we want to measure, and whether this concept, so defined, provides an optimal target for stroke therapy using state-of-the-art trial design
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    Immunoglobulin therapy in the 21st century: the dark side of the moon (2015)
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    ISBN: 9782889197033
    Sprache: Englisch
    Seiten: 1 Online-Ressource (124 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the early decades sinc ...
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    Information-based methods for neuroimaging: analyzing structure, function and dynamics (2015)
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    ISBN: 9782889195022
    Sprache: Englisch
    Seiten: 1 Online-Ressource (191 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The aim of this Research ...
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    Hemispheric Bases for Emotion and Memory (2015)
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    ISBN: 9782889194599
    Sprache: Englisch
    Seiten: 1 Online-Ressource (97 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: It has become clear that the two halves of the cortex differ in their contributions to both affective and memory processes. Still, the exact nature of the interrelationships among hemispheric function, emotion, and memory remains elusive. For example, controversy remains regarding differential hemispheric involvement in emotion, motivation, and affective style. Regarding memory, although evidence suggests differences in the manner in which the hemispheres interact may be related to memory retrieval, it is still not certain which factors involved in retrieval encourage or inhibit hemispheric communication. The goal of this Research Topic was to bring together diverse scientific perspectives on lateralized brain mechanisms underlying emotion, motivation, and memory. A range of international experts with diverse backgrounds, theoretical perspectives, and experimental methods contributed to the Topic. These contributions inform our understanding of lateralized affective and cognitive processes by providing thorough reviews of our current state of knowledge based on previous literature, by sharing intriguing new empirical findings, and by proposing theoretical models with testable frameworks to stimulate future research
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    Neural Circuits: Japan (2015)
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    ISBN: 9782889194377
    Sprache: Englisch
    Seiten: 1 Online-Ressource (220 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: This Frontiers Research Topic on ‘Neural Circuits: Japan’ explores the diversity of neural circuit research occurring across Japan by innovative researchers using cutting-edge approaches. This issue has brought together papers revealing the development, structure, and physiology of neuronal circuits involved in sensory perception, sleep and wakefulness, behavioral selection, and motor command generation in a range of species from the nematode to the primate. Like the USA and Europe, Japan is now making a strong effort to elucidate neural circuit function in diverse organisms by taking advantages of optogenetics and innovative approaches for gene manipulation, traditional physiological and anatomical approaches, and neural pathway-selective inactivation techniques that have recently been developed in Japan
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    The Natriuretic Hormones (2015)
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    ISBN: 9782889197095
    Sprache: Englisch
    Seiten: 1 Online-Ressource (76 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The title follows from the original demonstration by Dr. Hugh de Wardener in 1961 that a humoral agent is produced after extracellular volume expansion which results in a vigorous diuresis and natriuresis. Thus the name of "natriuretic hormone" was coined. In the years that followed several investigators pursued the search for the hormone. What resulted, however, was the discovery of several hormones with different characteristics, all of which were natriuretic. Initially it was found that the hormone was similar in action to ouabain or digoxin, hence the appelation of ouabain-like or digoxin-like. The hormone was found to be an inhibitor of Na-K-ATPase, which would fit with it being a cardiotonic steroid. On the other hand, neither ouabain or digoxin migrated on Sephadex gel filtration in the same locus as the hormone. Other investigators claim to have identified the hormone-initially as a vanadium-diascorbate, later as bufadienolides such as marinobufagenin, yet later as a macrocylic derivative of inorganic carbon suboxide with a molecular weight of 408 Da. Some support for the latter finding was derived from an earlier report that a semi-purified Sephadex-derived compound was found to have a molecular weight of about 12,000 Da but the active compound, when split from its carrier protein, had a molecular weight of exactly 408 Da. This compound had not been further identified. As further development was the demonstration by Bricker and colleagues that a natriuretic substance could be purified from uremic urine. This turned out to be a xathurenic acid derivative. Meanwhile the focus began to turn to natriuretic peptides derived from heart (ANF and BNP). These peptides have a shorter duration of action than the cardiotonic steroid-like hormone and ANF has proved to be most useful as a measure of heart failure. It should also be stressed that marinobufagenin, like ANF, is elevated in congestive heart failure, whereas the steroid-like hormone is depressed or absent in this state. This review will attempt to describe and contrast the properties of each of the proposed natriuretic hormones, including their locus on Sephadex separation, potency, duration of action, chemical structure (if known), behavior in hypertension, renal failure, heart failure, and brain disease. As most recent work has focussed on marinobufagenin, this hormone will be brought up to date by investigators in the field
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    Neuroanatomy and transgenic technologies (2015)
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    ISBN: 9782889195138
    Sprache: Englisch
    Seiten: 1 Online-Ressource (139 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions
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    Neuroactive metabolites of ethanol: a behavioral and neurochemical synopsis (2015)
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    ISBN: 9782889193752
    Sprache: Englisch
    Seiten: 1 Online-Ressource (126 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date synopsis of the behavioral and neurophysiological impact of the two direct metabolites of ethanol, acetaldehyde and acetate. In doing so, this issue will present human and rodent evidence on their behavioral and neurophysiological impact, either when administered alone as drugs, or when metabolically-derived from their parent compound. Emphasis will be placed to stress the importance of the different enzymatic systems that intervene to produce these metabolites, either peripherally and/or directly in the brain. Similarly, this Research Topic will be aimed at addressing some of the possible mechanisms of action of acetaldehyde and acetate in different brain areas and in different intracellular systems. Furthermore, the issue will lay out some of the suggested mechanisms of action of ethanol and of its metabolites by which they form adducts with other molecules and neurotransmitters such as dopamine and opioids (which lead to salsolinol and tetrahydropapaveroline, respectively), and their impact on the synthesis and actions of neuromodulators such as adenosine and the cannabinoid system
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    Non-Ordinary Mental Expressions (2015)
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    ISBN: 9782889194858
    Sprache: Englisch
    Seiten: 1 Online-Ressource (135 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: So-called altered states ...
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    New therapeutic targets for human placental angiogenesis diseases (2015)
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    ISBN: 9782889194612
    Sprache: Englisch
    Seiten: 1 Online-Ressource (113 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies
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  • 45
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    Neural processing of emotion in multimodal settings (2015)
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    ISBN: 9782889194148
    Sprache: Englisch
    Seiten: 1 Online-Ressource (274 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Our everyday life is characterized by a multitude of emotionally relevant cues that we perceive and communicate via various sensory channels. This does not only encompass the obvious cases of auditory and visual modalities, but also olfactory, gustatory, and even tactile stimuli. Any kind of emotional situation in a natural setting is usually a multimodal experience: A friend welcomes us with warm words, a smile, and a happy voice; the sight of our favourite food is accompanied by a seductive smell and a delicious taste; the thrill of watching an exciting movie scene is intensified by a gripping soundtrack. In these situations, the signals from various senses do not stand on their own; they interact and create a unified emotional experience. Recent neuroscientific research has begun to accommodate this inherent multimodality of emotions in natural situations by studying the interaction of affectively relevant information from more than one sensory channel. Fascinating new aspects emerge concerning the neurobiology of emotion processing, and there is evidence that integrating emotional cues from various sources invokes brain processes that go beyond the well-known patterns observed during unimodal stimulation. The aim of this volume is to present novel and interesting studies dealing with the multimodality of emotions and their neural processing. This includes findings from novel paradigms beyond the classical stimulus-response pattern, fascinating new insights into the interaction of the chemical senses, new analysis methods, comprehensive reviews of selected topics, multimodality in social interactions, and clinical perspectives. Taken together, the studies of this volume thus help us to better understand the interplay of various senses in our daily emotional experiences
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    Neuroscience perspectives on Security: Technology, Detection, and Decision Making (2015)
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    ISBN: 9782889196005
    Sprache: Englisch
    Seiten: 1 Online-Ressource (108 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In security science, effi ...
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    A Multidisciplinary Approach to Motor Learning and Sensorimotor Adaptation (2015)
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    ISBN: 9782889193653
    Sprache: Englisch
    Seiten: 1 Online-Ressource (214 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The plasticity of the living matter of our nervous system, in short, is the reason why we do a thing with difficulty the first time, but soon do it more and more easily, and finally, with sufficient practice, do it semi-mechanically, or with hardly any consciousness at all. William James, 1899. It is over 100 years since James described the acquisition of skill. How much, or how little, have recent advances in science changed the way we think about skill learning? What theories and ideas do we still hold dear and which have we discarded? Advances in neuroimaging over the past 20 years have provided insight into the dynamic neural processes underlying human motor skill acquisition, focusing primarily on brain networks that are engaged during early versus late stages of learning. What has been challenging for the field is to tightly link these shifting neural processes with what is known about measureable behavioral changes and strategic processes that occur during learning. The complex nature of behavior and strategy in motor learning often result in a trade-off between experimental control and external validity. The articles assembled for this special issue cut across a number of related disciplines and investigate skill learning across multiple domains. The broad range of theoretical, analytical and methodological approaches offer complementary approaches that can be exploited to develop integrated models of skilled learning. It is our hope that this collection inspires innovation and collaboration amongst researchers, and thereby, accelerates development of societally relevant translational paradigms
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    The Evolution and Development of the Antibody Repertoire (2015)
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    ISBN: 9782889195497
    Sprache: Englisch
    Seiten: 1 Online-Ressource (122 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes
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    Genetics and epigenetics of fetal alcohol spectrum disorders (2015)
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    ISBN: 9782889195732
    Sprache: Englisch
    Seiten: 1 Online-Ressource (114 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Women drinking during pre ...
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  • 50
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    From Brain to Body: The Impact of Nervous System Declines on Muscle Performance in Aging (2015)
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    ISBN: 9782889196869
    Sprache: Englisch
    Seiten: 1 Online-Ressource (154 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The deterioration of skel ...
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889194728
    Sprache: Englisch
    Seiten: 1 Online-Ressource (104 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches
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    Functional Imaging in living Plants - Cell Biology meets Physiology (2015)
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    ISBN: 9782889194650
    Sprache: Englisch
    Seiten: 1 Online-Ressource (114 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The study of plant cell p ...
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    Dopaminergic Foundations of Personality and Individual Differences (2015)
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    ISBN: 9782889194322
    Sprache: Englisch
    Seiten: 1 Online-Ressource (188 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: For several decades, theory and research has drawn links between dopaminergic neurotransmission and various aspects of personality and individual differences, as well as major personality processes. Recent increases in the availability and affordability of neuroscience methods have permitted thorough investigation of such links as part of the thriving field of personality neuroscience. However, the picture emerging from this body of research is somewhat puzzling; Rather than being linked to only a few converging dimensions of individual differences in psychological functioning, dopamine seems to be associated with a wide range of rather disparate traits and psychopathological conditions including (among various others) impulsivity, extraversion, anxiety, reward sensitivity, approach behaviour, achievement motivation, working memory performance, cognitive flexibility, depression, anhedonia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Empirical research in this area typically focuses on only one piece of this puzzle based on a specific strand of theory and a narrow section of relevant prior findings. The present research topic will, for the first time, attempt to provide a fairly complete picture of the whole puzzle including all its disparate parts. Contributors will therefore be explicitly encouraged to go beyond their own specific dopamine-personality hypotheses and place their work in a broader context, thereby helping to forge links between largely non-overlapping research traditions
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    Distributed Networks: New Outlooks on Cerebellar Function (2015)
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    ISBN: 9782889196265
    Sprache: Englisch
    Seiten: 1 Online-Ressource (211 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Accumulating evidence suggests that the cerebellum subserves functions beyond the sensorimotor realm. This possibility has received considerable attention during the past quarter century, with recent findings revealing putative cerebellar roles in cognition, emotion and spatial navigation. These functions are potentially underpinned by the behaviour-dependent formation of functional networks in which the cerebellum forms one node of distributed circuits spanning thalamic, limbic and neocortical regions. However, these views are not universally accepted. Therefore, the over-arching aim of this Research Topic was to provide a forum through which the debate on the role of cerebellar interactions with motor and "non-motor" structures can be pursued in a rigorous manner. In particular, we aimed to bring together findings from the clinical, animal, theoretical and neuroimaging fields
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    Development of the Hypothalamus (2015)
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    ISBN: 9782889196340
    Sprache: Englisch
    Seiten: 1 Online-Ressource (264 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The hypothalamus is the region of the brain in charge of the maintenance of the internal milieu of the organism. It is also essential to orchestrate reproductive, parental, aggressive-defensive, and other social behaviors, and for the expression of emotions. Due to the structural complexity of the hypothalamus, however, many basic aspects of its ontogenesis are still mysterious. Nowadays we assist to a renewal of interest spurred in part by the growing realization that prenatal and early postnatal influences on the hypothalamus could entail pathological conditions later in life. Intriguing questions for the future include: do early specification phenomena reflect on adult hypothalamic function and possibly on some kinds of behavior? Can early events like specification, migration or formation of nuclei influence adult hypothalamic function? A change in morphological paradigm, from earlier columnar interpretations to neuromeric ones, is taking place. Concepts long taken for granted start to be challenged in view of advances in developmental and comparative neurobiology, and notably also in the molecular characterization of hypothalamic structures. How should we understand the position of the hypothalamus in relation to other brain regions? Should we bundle it together with the thalamus, a functionally, genetically and developmentally very different structure? Does the classic concept of “diencephalon” make sense, or should the hypothalamus be separated? Does the preoptic area belong to the hypothalamus or the telencephalon? The answer to these questions in the context of recent causal molecular analysis will help to understand hypothalamic evolution and morphogenesis as well as its adult function and connectivity. In this Research Topic we have reviewed the fundamentals of hypothalamic ontogenesis and evolution, summarizing present-day knowledge, taking stock of the latest advances, and anticipating future challenges
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    Criticality as a signature of healthy neural systems: multi-scale experimental and computational studies (2015)
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    ISBN: 9782889195039
    Sprache: Englisch
    Seiten: 1 Online-Ressource (139 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Since 2003, when spontaneous activity in cortical slices was first found to follow scale-free statistical distributions in size and duration, increasing experimental evidences and theoretical models have been reported in the literature supporting the emergence of evidence of scale invariance in the cortex. Although strongly debated, such results refer to many different in vitro and in vivo preparations (awake monkeys, anesthetized rats and cats, in vitro slices and dissociated cultures), suggesting that power law distributions and scale free correlations are a very general and robust feature of cortical activity that has been conserved across species as specific substrate for information storage, transmission and processing. Equally important is that the features reminiscent of scale invariance and criticality are observed at scale spanning from the level of interacting arrays of neurons all the way up to correlations across the entire brain. Thus, if we accept that the brain operates near a critical point, little is known about the causes and/or consequences of a loss of criticality and its relation with brain diseases (e.g. epilepsy). The study of how pathogenetical mechanisms are related to the critical/non-critical behavior of neuronal networks would likely provide new insights into the cellular and synaptic determinants of the emergence of critical-like dynamics and structures in neural systems. At the same time, the relation between the impaired behavior and the disruption of criticality would help clarify its role in normal brain function. The main objective of this Research Topic is to investigate the emergence/disruption of the emergent critical-like states in healthy/impaired neural systems
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    The cognitive, emotional and neural correlates of creativity (2015)
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    ISBN: 9782889196333
    Sprache: Englisch
    Seiten: 1 Online-Ressource (98 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Across species, humans have an unsurpassed capacity for creative thought and innovation. Human creativity is at the roots of extraordinary achievements in the arts and sciences, and enables individuals and their groups to adapt flexibly to changing circumstances, to manage complex social relations, and to survive and prosper through social, technological, and medical innovations. The ability to generate novel and potentially useful ideas and problem solutions (viz., creativity) is a key driver of human evolution, and among the most valued and sought after competencies in contemporary societies that struggle with complex problems and compete for technological and economic supremacy. Because creativity provides fitness functionality in both ancestral and contemporary societies, it stands to reason that (i) the human brain evolved to sustain and promote creative thinking and we should be able to identify (ii) the brain circuitries, genetic drivers, and neurohormonal modulators of the human capacity for creative problem solving and original ideation; and (iii) the core cognitive and emotional processes underlying creative thought. In this Research Topic, we bring together a collection of papers to provide an encyclopedic, open access snapshot of the current state of the art on the neural, cognitive, and emotional correlates of creativity
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    Cognitive deficits in schizophrenia and other neuropsychiatric disorders: Convergence of preclinical and clinical evidence (2015)
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    ISBN: 9782889196791
    Sprache: Englisch
    Seiten: 1 Online-Ressource (283 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances
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    Chemokines and chemokine receptors in brain homeostasis (2015)
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    ISBN: 9782889196166
    Sprache: Englisch
    Seiten: 1 Online-Ressource (124 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Virtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain enviroment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication
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    Chromatin & Transcriptional Tango on the Immune Dance Floor (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889195107
    Sprache: Englisch
    Seiten: 1 Online-Ressource (144 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Signaling through the cell surface antigen receptor is a hallmark of various stages of lymphocyte development and adaptive immunity. Besides the adaptive immune system, the innate immunity is equally important for protection. However, the mechanistic connection between signaling, chromatin changes and downstream transcriptional pathways in both innate and adaptive immune system remains incompletely understood in hematopoiesis. A related issue is how the enhancers communicate to the promoters in a stage specific fashion and in the context of chromatin. Because the factors that regulate chromatin are generally present and active in most cell types, how could cell type and/or stage specific chromatin architecture is achieved in response to a particular immune signal?The genetic loci that encode lymphocyte cell surface receptors are in an "unrearranged” or “germline” configuration during the early stages of development. Thus, in addition to expressing lineage and/or stage specific transcription factors during each developmental stage, lymphocytes also need to rearrange their cognate receptor loci in a strictly ordered fashion. Hence, there must be a tightly coordinated communication between the recombination machinery and the transcriptional machinery (including chromatin regulators) at every developmental step. Mature B cells also undergo classswitch recombination and somatic hypermutation. Importantly, along the way, these cells must avoid autoimmune responses and only those cells capable of recognizing foreignantigens are preserved to reach peripheral organs where they must function. The exquisite regulation that govern chromatin accessibility, recombination and transcription regulation in response to the environmental signals in the immune system is discussed here is a series of articles
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    The biology and ecology of ticks shape the potential for the transmission of zoonotic pathogens (2015)
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    ISBN: 9782889194063
    Sprache: Englisch
    Seiten: 1 Online-Ressource (179 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Ticks are noticeable by t ...
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    Bridging the gap before and after birth: Methods and technologies to explore the functional neural development in humans (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889196876
    Sprache: Englisch
    Seiten: 1 Online-Ressource (114 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Infant brain damage is a serious condition that affects millions of babies each year. The period from late gestation to the first year of life is the most critical one for the development of central and autonomous nervous systems. Medical conditions such as preterm birth may compromise brain function and the end result usually is that the baby may experience long-term neurological problems related to a wide range of psychological, physical and functional complications, with consequent life-long burdens for the individuals and their families, and a high socio-economic impact for the health care system and the whole of society. During the last years, several techniques have been employed to monitor the brain functional development in utero and after birth. As well, various analytical methods have been used to understand the functional maturation of the brain and the autonomous nervous system. However, in spite of the rapid improvement of diagnostic methods and procedures, there is still a widely recognized, severe shortage of clinically viable means for the high quality monitoring of the brain function in early life with a direct relevance to acute neurological illness and future neurocognitive outcomes. The studies collected in this e-book document the most recent advancements in monitoring systems, analytical methods and clinical diagnostic procedures that contribute to increase our knowledge of the functional development of the human brain and autonomous nervous system during pregnancy and after birth, with the ultimate goal of reducing fetal impairment and improving healthcare in the neonatal and infant period
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    Autism: The Movement Perspective (2015)
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    ISBN: 9782889195091
    Sprache: Englisch
    Seiten: 1 Online-Ressource (374 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Autism Spectrum Disorders ...
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    Behavioral and physiological bases of attentional biases: Paradigms, participants, and stimuli (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889196401
    Sprache: Englisch
    Seiten: 1 Online-Ressource (96 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Attentional biases (ABs) ...
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    Beyond the Iron Age: The ecological relevance of bioactive trace metals other than Fe and organic growth factors in aquatic systems (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889195466
    Sprache: Englisch
    Seiten: 1 Online-Ressource (109 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the last three decades, research has extensively focused on the role of Fe and other mineral nutrients in regulating biological processes, ranging from the surface to the deep ocean. This has produced major breakthroughs in our understanding of the fundamental role of those bioactive elements on the carbon, nitrogen and sulfur cycles and ecosystem function. However, biological processes cannot be entirely sustained by that small set of chemical elements, and new scientific evidence suggests that trace metals other than Fe (e.g., Co, Mo and Ni) as well as essential organic growth factors (e.g., vitamins) may also be crucial in most aquatic systems
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    Attachment Assessment in treatments, prevention and intervention programs (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889195237
    Sprache: Englisch
    Seiten: 1 Online-Ressource (104 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Attachment theory, assessment and research offers a broad, far-reaching view of human functioning, and it can enrich a psychologist's understanding of subjects and their relational adjustment, both in clinical and non-clinical settings. Ongoing research in attachment has led to a number of individual treatments and prevention and intervention programs. The assessment of an individual's attachment organization, can play a crucial role in explaining and previewing the unfolding treatment, the relational adjustments or concerns, and the psychological well-being. We hope to receive empirical papers that give evidence for the usefulness of attachment assessment in both clinical (e.g., patients with Eating Disorder; or Axis-II; psychotherapy patients…) or not clinical population (e.g. Adoptive and/or foster families or couples, Mother-infant assessment in prevention field…). These papers should include methodological issues and information about the participants, the methods used to assess attachment, the process of scorer training and the availability of the manual used to obtain inter-scorer reliability. Case studies may be of interest to the extent that they demonstrate the value of a systematic approach to attachment material. A range of theoretical perspectives is welcome as well presentation of new emergent tools on attachment. Because Frontiers in Psychology is an international journal, each empirical paper should comment on the international implications of the findings and discuss its cross-cultural use. Such comments may include, for example, its linguistic specificity, its robustness in translation, and the cross-cultural generalizability of the constructs and behaviors of the measure and its usual correlates. Cross-cultural generalizability is not, however, a requirement
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    Attention, predictions and expectations and their violation: attentional control in the human brain (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889193677
    Sprache: Englisch
    Seiten: 1 Online-Ressource (211 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: In the burdened scenes of ...
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    ATP-gated P2X receptors in Health and Disease (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889194056
    Sprache: Englisch
    Seiten: 1 Online-Ressource (172 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases
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    The causes and consequences of microbial community structure (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889193615
    Sprache: Englisch
    Seiten: 1 Online-Ressource (184 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The causes and consequences of differences in microbial community structure, defined here as the relative proportions of rare and abundant organisms within a community, are poorly understood. Articles in "The Causes and Consequences of Microbial Community Structure", use empirical or modeling approaches as well as literature reviews to enrich our mechanistic understanding of the controls over the relationship between community structure and ecosystem processes. Specifically, authors address the role of trait distributions and tradeoffs, species-species interactions, evolutionary dynamics, community assembly processes and physical controls in affecting ‘who’s there’ and ‘what they are doing’
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    Bacterial pathogens in the non-clinical environment (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889195589
    Sprache: Englisch
    Seiten: 1 Online-Ressource (100 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The transmission route used by many bacterial pathogens of clinical importance includes a step outside the host; thereafter refer to as the non-clinical environment (NCE). Obvious examples include foodborne and waterborne pathogens and also pathogens that are transmitted by hands or aerosols. In the NCE, pathogens have to cope with the presence of toxic compounds, sub-optimal temperature, starvation, presence of competitors and predators. Adaptation of bacterial pathogens to such stresses affects their interaction with the host. This Research Topic presents important concept to understand the life of bacterial pathogens in the NCE and provides the reader with an overview of the strategies used by bacterial pathogens to survive and replicate outside the host
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    Animal model studies on viral infections (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889194568
    Sprache: Englisch
    Seiten: 1 Online-Ressource (173 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Understanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures against viruses. To fight against a wide variety of viruses, basic studies with specific and/ or common approaches are required. This Research Topic collects articles that describe studies on numerous virus species at various stages toward animal experiments: (i) description/evaluation/ new challenges of animal model studies; (ii) experimental material/methods for animal model studies; (iii) observations for upcoming animal model studies. Numbers of DNA and RNA viruses such as HHV-6, HPV, Ebola virus, HCV, dengue virus, HTLV-1, HIV-1, SIV, and measles virus are covered by this special issue consisting of original research, methods, review, mini-review, and opinion articles. All readers would understand, we believe and hope, that animal model studies are critical for current virology as always
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    Advances in Seed Biology (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889196753
    Sprache: Englisch
    Seiten: 1 Online-Ressource (238 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The seed plays a fundamental role in plant reproduction as well as a key source of energy, nutrients and raw materials for developing and sustaining humanity. With an expanding and generally more affluent world population projected to reach nine billion by mid-century, coupled to diminishing availability of inputs, agriculture is facing increasing challenges to ensure sufficient grain production. A deeper understanding of seed development, evolution and physiology will undoubtedly provide a fundamental basis to improve plant breeding practices and ultimately crop yields. Recent advances in genetic, biochemical, molecular and physiological research, mostly brought about by the deployment of novel high-throughput and high-sensitivity technologies, have begun to uncover and connect the molecular networks that control and integrate different aspects of seed development and help determine the economic value of grain crops with unprecedented details. The objective of this e-book is to provide a compilation of original research articles, reviews, hypotheses and perspectives that have recently been published in Frontiers in Plant Science, Plant Evolution and Development as part of the Research Topic entitled "Advances in Seed Biology". Editing this Research Topic has been an extremely interesting, educational and rewarding experience, and we sincerely thank all authors who contributed their expertise and in-depth knowledge of the different topics discussed. We hope that the information presented here will help to establish the state of the art of this field and will convey how exciting and important studying seeds is and hopefully will stimulate a new crop of scientists devoted to investigating the biology of seeds
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    "One rotten apple spoils the whole barrel": The plant hormone ethylene, the small molecule and its complexity (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889196234
    Sprache: Englisch
    Seiten: 1 Online-Ressource (132 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: The gaseous molecule ethylene (C2H4), which is small in size and simple in structure, is a plant hormone most often associated with fruit ripening yet has a diversity of effects throughout the plant life cycle. While its agricultural effects were known even in ancient Egypt, the complexity of its mode of action and the broad spectrum of its effects and potential uses in plant physiology remain important scientific challenges today. In the last few decades, the biochemical pathway of ethylene production has been uncovered, ethylene perception and signaling have been molecularly dissected, ethylene-responsive transcription factors have been identified and numerous effects of ethylene have been described, ranging from water stress, development, senescence, reproduction plant-pathogen interactions, and of course, ripening. Thus ethylene is involved in plant development, in biotic and abiotic stress, and in reproduction. There is no stage in plant life that is not affected by ethylene, modulated by a complex and fascinating molecular machinery
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    30 years of the Comet Assay: an overview with some new insights (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889196494
    Sprache: Englisch
    Seiten: 1 Online-Ressource (174 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: By means of this ‘Frontie ...
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    30 years old: O-GlcNAc Reaches Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889195916
    Sprache: Englisch
    Seiten: 1 Online-Ressource (113 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart
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    Aging, neurogenesis and neuroinflammation in hearing loss and protection (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889196449
    Sprache: Englisch
    Seiten: 1 Online-Ressource (151 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease. In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes to molecules involved in aging. Oxidative stress takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies
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    2015: Which new directions for Alzheimer's disease? (2015)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889195350
    Sprache: Englisch
    Seiten: 1 Online-Ressource (122 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: According to the World Health Organization, more than 40 million people in the world are affected with dementia. To date, 60-70% of the cases of dementia are attributed to the Alzheimer's disease (AD). This neurodegenerative disorder gradually takes place over a period of at least 20 years before the onset of symptoms, which are impaired memory, apathy and depression. The characteristics of AD consist in neurofibrillary tangles (intraneuronal aggregates of hyperphosphorylated tau proteins) and senile plaques (dense extraneuronal deposits composed of amyloid ß (Aß)). The other features linked to these two core pathological hallmarks of AD are inflammation, oxidative stress, progressive synaptic and neuronal loss. In past years, some of the emerging therapeutic strategies against AD were employed to deal with the pathological hallmarks of the disease. Science teams all over the world try to restore the tau phosphorylation equilibrium. Their purpose is to interfere with the aggregation of tau and decrease its amount of proteins per se as well. Furthermore, they are trying either to stimulate the elimination processes of the aggregated tau proteins or to stop the formation of Aß peptides. This could be reached by the stimulation of the classic techniques of protein degradation such as the autophagic pathway, or by the targeted immunotherapy. In this Research Topic, we wish to summarize and review the etiology of AD and the related therapeutic opportunities for the next decades. To fully understand the precise mechanisms underlying AD, research findings, reviews, new insights and new approaches include AD and related tauopathies, tau phosphorylation balance, pharmacological compounds against AD, neuroprotection strategies and new therapeutic ways but also risk factors for AD and AD genetic information are included in this issue
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    Gefährliche Körper an gefährlichen Orten : Eine Studie zum Verhältnis von Körper, Raum und Marginalisierung (2015)
    Bielefeld : transcript | Ann Arbor, Michigan : ProQuest
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    ISBN: 9783839411155
    Sprache: Deutsch
    Seiten: 1 Online-Rressource (270 Seiten)
    Serie: Materialitäten Band 9
    Serie: Materialitäten
    Paralleltitel: Erscheint auch als
    Dissertationsvermerk: Dissertation Universität Hamburg, Fachbereich Sozialwissenschaften 2007
    RVK:
    LC 59000
    RVK:
    MS 9050
    RVK:
    MR 1100
    RVK:
    LB 52000
    Schlagwort(e): Crime ; Equality ; Human body Social aspects ; Internal security ; Marginality, Social ; Social security ; Ausgrenzung ; Körperbild ; Großstadt ; Gefahr ; Marginalität ; Soziale Norm ; Sicherheit ; Öffentlicher Raum ; Kontrolle ; Kriminalsoziologie ; Raum ; Social Inequality ; Social Relations ; Sociology of Crime ; Sociology ; Soziale Ungleichheit ; Sozialität ; Soziologie ; Space ; Stadt ; Urban Studies ; Urbanity ; Ausgrenzung ; Öffentlicher Raum ; Körperbild ; Soziale Norm ; Marginalität ; Sicherheit ; Großstadt ; Gefahr ; Exklusion ; Gesellschaftstheorie ; Körper / Körperlichkeit ; Marginalisierung ; Raum / Inklusion ; Soziologie ; soziale Ungleichheit ; Equality ; Electronic books ; SOCIAL SCIENCE / Popular Culture ; Hochschulschrift ; Körperbild ; Soziale Norm ; Marginalität ; Gefahr ; Großstadt ; Öffentlicher Raum ; Sicherheit ; Ausgrenzung
    Kurzfassung: Wie werden Körper gefährlich? Dieser Frage liegt die These zugrunde, dass soziale Prozesse der In- und Exklusion, der Normalisierung und Marginalisierung von Menschen und Gruppen immer auch eine körperliche Dimension haben. Das Buch verknüpft erstmals die für die Soziologie seit längerem virulente Frage nach der Bedeutung des Körperlichen mit Theorien zu sozialer Ungleichheit, zu Stadt und Raum sowie zur Sicherheitsgesellschaft und illustriert diese auch empirisch an einem innerstädtischen "gefährlichen Ort". Auf diesem Wege wird eine Öffnung der körperlichen Dimension des Sozialen für eine kritische Gesellschaftstheorie erreicht.
    Kurzfassung: Cover Gefährliche Körper an gefährlichen Orten -- Inhalt -- Prolog -- Einleitung -- 1. Marginalisierung -- 1.1 Diskussionen um soziale Ungleichheit -- 1.2 Neue Phänomene, neue Konzepte? -- 1.3 Exklusion und Underclass -- 1.4 Diskussion -- 2. Stadt und Raum -- 2.1 Ausgrenzende Stadt? -- 2.2 Raum als sozialwissenschaftliche Kategorie -- 2.3 Raum als soziale Praxis -- 2.4 Diskussion -- 3. Sicherheit und Gefahr -- 3.1 Sicherheit als Mythos? -- 3.2 Neue Formen der (räumlichen) Kontrolle -- 3.3 Theoretische Erklärungen -- 3.4 Diskussion -- 4. Körper -- 4.1 Die Soziologie und der Körper: body turn? -- 4.2 Körper als soziale Praxis -- 4.3 Körper gesellschaftstheoretisch -- 4.4 Diskussion -- 5. Zwischenresümee Theorie -- 6. Gegenstand und Methode -- 6.1 Beschreibung des Gegenstands: Hansaplatz gestern und heute -- 6.2 Methode -- 7. Diskursanalyse: Der Hansaplatz als gefährlicher Ort -- 7.1 Zeitungsartikel -- 7.2 Senatsdrucksachen -- 7.3 Stimmen der Stadtteilbewohner/innen -- 7.4 Dramaturgie -- 8. Beobachtungsprotokolle -- 9. Interviews -- 9.1 Sample und Einzelbeschreibungen der Interviews -- 9.2 Auswertung der Interviews -- 10. Zwischenresümee der empirischen Studie -- Schluss: Gefährliche Körper an gefährlichen Orten -- Literatur.
    Kurzfassung: "Imke Schmincke gelingt es in ihrer durchweg verständlich geschriebenen Studie zum Verhältnis von Körper, Raum und Marginalisierung sehr stichhaltig, die Bedeutung des Körperlichen für die soziale Ungleichheitsforschung herauszuarbeiten [...]." Zara Simone Pfeiffer, www.querelles-net.de, 10.11.2009. Besprochen in: Zeitschrift für Rechtssoziologie, 30/2 (2009), Rüdiger Lautmann
    Anmerkung: Literaturverzeichnis: Seiten 247-268 , Lizenzpflichtig
    DOI: 10.14361/9783839411155
    URL: https://elibrary.utb.de/doi/book/10.5555/9783839411155
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  • 79
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    Online-Ressource
    Mittlersubjekte der Migration : Eine Praxeographie der Selbstbildung von Integrationslotsen (2015)
    Bielefeld : transcript Verlag | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783839432600
    Sprache: Deutsch
    Seiten: 1 Online-Ressource (381 pages)
    Ausgabe: 1st ed.
    Serie: Praktiken der Subjektivierung v.7
    DDC: 305.90691209430003
    RVK:
    MR 5200
    RVK:
    MS 3600
    RVK:
    MS 6470
    Schlagwort(e): Einwanderer ; Begleitung ; Soziale Integration ; Kurs ; Teilnehmer ; Migrationshintergrund ; Qualifizierungsprozess ; Selbstbild ; Hochschulschrift ; Electronic books
    Anmerkung: Description based on publisher supplied metadata and other sources
    URL: Volltext
    URL: Volltext
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  • 80
    Online-Ressource
    Online-Ressource
    Revisiting Multiculturalism in Canada : Theories, Policies and Debates (2015)
    Rotterdam : Sense Publishers | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9789463002080
    Sprache: Englisch
    Seiten: 1 Online-Ressource (340 pages)
    Serie: Transnational Migration and Education v.1
    DDC: 305.800971
    RVK:
    LB 48605
    RVK:
    MG 72920
    Schlagwort(e): Aufsatzsammlung
    Anmerkung: Description based on publisher supplied metadata and other sources
    URL: Volltext  (lizenzpflichtig)
    URL: Volltext
    URL: Inhaltsverzeichnis
    URL: Abstract
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  • 81
    Online-Ressource
    Online-Ressource
    Gangs of Russia : From the Streets to the Corridors of Power (2015)
    Ithaca : Cornell University Press | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781501701689
    Sprache: Englisch
    Seiten: 1 Online-Ressource (288 pages)
    DDC: 364.10660947
    RVK:
    LB 47326
    Schlagwort(e): Geschichte 1990-2005 ; Organisiertes Verbrechen ; Bande ; Kasan ; Moskau
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 82
    Online-Ressource
    Online-Ressource
    Economy and Ritual : Studies in Postsocialist Transformations (2015)
    New York, NY : Berghahn Books | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781782385707
    Sprache: Englisch
    Seiten: 1 Online-Ressource (214 pages)
    Ausgabe: 1st ed.
    Serie: Max Planck Studies in Anthropology and Economy v.1
    DDC: 305.8009171
    RVK:
    LB 58269
    Schlagwort(e): Wirtschaft ; Lebenswelt ; Ritual ; Osteuropa ; Aufsatzsammlung ; Aufsatzsammlung
    Kurzfassung: According to accepted wisdom, rational practices and ritual action are opposed. Rituals drain wealth from capital investment and draw on a mode of thought different from practical ideas. The studies in this volume contest this view. Comparative, historical, and contemporary, the six ethnographies extend from Macedonia to Kyrgyzstan. Each one illuminates the economic and ritual changes in an area as it emerged from socialism and (re-)entered market society. Cutting against the idea that economy only means markets and that market action exhausts the meaning of economy, the studies show that much of what is critical for a people's economic life takes place outside markets and hinges on ritual, understood as the negation of the everyday world of economising.
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  • 83
    Online-Ressource
    Online-Ressource
    Narrating the City : Histories, Space and the Everyday (2015)
    New York, NY : Berghahn Books | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781782387763
    Sprache: Englisch
    Seiten: 1 Online-Ressource (266 pages)
    Ausgabe: 1st ed.
    Serie: Space and Place v.15
    DDC: 307.76
    RVK:
    LB 73000
    RVK:
    MS 1750
    Schlagwort(e): Stadtleben ; Geschichtsschreibung ; Literatur ; Film ; Arbeiterklasse ; Bürgertum ; Mittelstand ; Öffentlicher Raum ; Gesellschaftsleben ; Erzähltheorie ; Rhetorik ; Diskursanalyse ; Erzählforschung ; Textanalyse ; Aufsatzsammlung
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 84
    Online-Ressource
    Online-Ressource
    Ageing in Europe - Supporting Policies for an Inclusive Society (2015)
    Berlin/Boston : De Gruyter | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783110444414
    Sprache: Englisch
    Seiten: 1 Online-Ressource (392 pages)
    DDC: 305.26094
    RVK:
    MS 2700
    Schlagwort(e): Armut ; Älterer Mensch ; Ausgrenzung ; Inklusion ; Europa ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung ; Aufsatzsammlung
    Anmerkung: Description based on publisher supplied metadata and other sources
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Inhaltsverzeichnis
    URL: kostenfrei
    URL: Cover
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Inhaltsverzeichnis
    URL: Volltext  (kostenfrei)
    URL: Volltext  (Open Access)
    URL: Open Access
    URL: Inhaltsverzeichnis
    URL: Cover
    URL: Cover
    URL: Cover  (lizenzpflichtig)
    URL: kostenfrei
    URL: Volltext  (kostenfrei)
    URL: Volltext  (Open Access)
    URL: Open Access
    URL: Inhaltsverzeichnis
    URL: Cover
    URL: Cover
    URL: Cover  (lizenzpflichtig)
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  • 85
    Online-Ressource
    Online-Ressource
    Sociolinguistic Development of Voseo in the Andean Region of Colombia (2015)
    Berlin/Boston : De Gruyter | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783110404142
    Sprache: Spanisch
    Seiten: 1 Online-Ressource (350 pages)
    Serie: Beihefte Zur Zeitschrift Für Romanische Philologie Ser. v.392
    DDC: 306.44/26108612
    RVK:
    IM 9780
    Schlagwort(e): Geschichte 1555-1976 ; Spanisch ; Anredepronomen ; vos ; Soziolinguistik ; Kolumbien ; Anden
    Kurzfassung: The book series Beihefte zur Zeitschrift für romanische Philologie is among the most renowned publications in Romance Studies. It covers the entire field of Romance linguistics, including the national languages as well as the lesser studied Romance languages. The series publishes high-quality monographs and collected volumes on all areas of linguistic research, on medieval literature and on textual criticism.
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 86
    Online-Ressource
    Online-Ressource
    Les Gasconnades de l'amour : Scènes de la vie parisienne (2015)
    Brussels : Primento Digital Publishing | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9782335050646
    Sprache: Französisch
    Seiten: 1 Online-Ressource (195 pages)
    DDC: 306.76620944000001
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 87
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    Média v pohybu : K proměně současných českých publik (2015)
    Brno : Masarykova univerzita | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9788021080348
    Sprache: Tschechisch
    Seiten: 1 Online-Ressource (138 pages)
    DDC: 305.509437
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  • 88
    Online-Ressource
    Online-Ressource
    The Vampire in Folklore, History, Literature, Film and Television : A Comprehensive Bibliography (2015)
    Jefferson : McFarland & Company | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781476620831
    Sprache: Englisch
    Seiten: 1 Online-Ressource (389 pages)
    DDC: 016.398/45
    RVK:
    EC 5410
    Schlagwort(e): Vampires in mass media ; Electronic books
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 89
    Online-Ressource
    Online-Ressource
    Class, Culture and Space : The Construction and Shaping of Communal Space in South Thailand (2015)
    Bielefeld : transcript | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783839400517
    Sprache: Englisch
    Seiten: 1 Online-Ressource (195 pages)
    Ausgabe: 1st ed.
    Serie: Kultur und soziale Praxis
    DDC: 306.09593
    Schlagwort(e): Soziokultureller Wandel ; Mittelstand ; Thailand ; Electronic books
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 90
    Online-Ressource
    Online-Ressource
    Alles hat seine Zeit : Ein Lesebuch zur Hochaltrigkeit (2015)
    Zürich : TVZ Theologischer Verlag Zürich | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783290181239
    Sprache: Deutsch
    Seiten: 1 Online-Ressource (128 pages)
    DDC: 305.26
    Schlagwort(e): Alter ; Lebensführung ; Sozialer Wandel ; Spiritualität ; Older people--Social conditions ; Aufsatzsammlung ; Electronic books
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 91
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    Online-Ressource
    Global Tangos : Travels in the Transnational Imaginary (2015)
    Cranbury : Bucknell University Press | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781611486537
    Sprache: Englisch
    Seiten: 1 Online-Ressource (253 pages)
    DDC: 793.33
    RVK:
    LC 88670
    RVK:
    LC 88000
    RVK:
    LB 52800
    Schlagwort(e): Dance and globalization ; Electronic books
    Kurzfassung: Global Tangos starts from the premise that Argentine tango may be used as a way to understand the profound transformations that have taken place as a result of two of the defining features of globalization: transnationalism and the rise of social media.
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 92
    Online-Ressource
    Online-Ressource
    Neoliberal Rhetorics and Body Politics : Plastinate Exhibits as Infiltration (2015)
    Lanham, MD : Lexington Books | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781498523042
    Sprache: Englisch
    Seiten: 1 Online-Ressource (135 pages)
    Serie: Cultural Studies/Pedagogy/Activism
    DDC: 801.95
    Schlagwort(e): Cadaver in art - Moral and ethical aspects ; Electronic books
    Kurzfassung: Articulating how the plastinate exhibits BODY WORLDS and BODIES…The Exhibition offer tangible and rich sites within which to understand neoliberalism's impact beyond the purview of public policy, this book identifies the rhetorical mechanisms and methodologies that propel neoliberalism's travel. Focusing its analysis on the shows' rhetorical deployment of necropolitics, biopolitics, intimacy, and affect, it illustrates how a pop-cultural artifact can both reach individual viewers and reflect the transnational and neoliberal relationship between nation-states.
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  • 93
    Online-Ressource
    Online-Ressource
    Adolescents Rewrite their Worlds : Using Literature to Illustrate Writing Forms (2015)
    Lanham : Rowman & Littlefield Publishers | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781475813241
    Sprache: Englisch
    Seiten: 1 Online-Ressource (183 pages)
    DDC: 428.0071/2
    Schlagwort(e): Creative writing (Middle school) ; Language arts (Middle school) ; English language-Composition and exercises-Study and teaching (Middle school) ; Literature-Study and teaching (Middle school) ; Children's stories ; Electronic books
    Kurzfassung: Adolescents Rewrite their Worlds offers alternative ways teachers can engage young adolescents with the writing process using literature. The contributors discuss the values of writing in twenty-first century classrooms and global societies, remarking that writing is first a personal exploration that is informed by cultural practices.
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  • 94
    Online-Ressource
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    The Composition of Movements to Come : Aesthetics and Cultural Labour After the Avant-Garde (2015)
    London : Rowman & Littlefield Publishers | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781783481743
    Sprache: Englisch
    Seiten: 1 Online-Ressource (199 pages)
    Ausgabe: 1st ed.
    Serie: New Politics of Autonomy
    DDC: 335.401
    RVK:
    LH 61040
    Schlagwort(e): Aesthetics - Political aspects ; Electronic books
    Kurzfassung: This text theorizes political change from within social movement via an engagement with autonomist politics and radical aesthetics.
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  • 95
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    Ethik, Ethos, Ethnos : Aspekte und Probleme interkultureller Ethik (2015)
    Bielefeld : transcript | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783839404904
    Sprache: Deutsch
    Seiten: 1 Online-Ressource (432 pages)
    Ausgabe: 1st ed.
    Serie: Kultur und soziale Praxis
    RVK:
    BK 1600
    RVK:
    CB 4200
    RVK:
    CC 7100
    RVK:
    CC 7200
    RVK:
    LB 33000
    Schlagwort(e): Ethik ; Aufsatzsammlung ; Electronic books
    Anmerkung: Description based on publisher supplied metadata and other sources
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  • 96
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    Online-Ressource
    Sexueller Missbrauch von Kindern und Jugendlichen : Ein Handbuch zur Prävention und Intervention für Fachkräfte im medizinischen, psychotherapeutischen und pädagogischen Bereich (2015)
    Berlin, Heidelberg : Springer Berlin Heidelberg | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9783662442449
    Sprache: Deutsch
    Seiten: 1 Online-Ressource (XXIX, 506 Seiten) , Illustrationen
    DDC: 362.767
    RVK:
    DS 7100
    RVK:
    DS 7170
    RVK:
    MS 2880
    RVK:
    PH 8820
    RVK:
    DU 1009
    RVK:
    BQ 6025
    Schlagwort(e): Kind ; Jugend ; Sexueller Missbrauch ; Prävention ; Developmental psychology ; Family medicine ; Medicine ; Psychiatry
    Anmerkung: Literaturangaben
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  • 97
    Online-Ressource
    Online-Ressource
    The politics of third wave feminism : neoliberalism, intersectionality, and the state in Britain and the US (2015)
    Basingstoke : Palgrave Macmillan | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781137295279
    Sprache: Englisch
    Seiten: 1 Online-Ressource (viii, 237 Seiten)
    Serie: Gender and politics series
    DDC: 305.42
    RVK:
    MS 3100
    RVK:
    MS 3200
    Schlagwort(e): Geschichte 1990-2014 ; Feminismus ; USA ; Großbritannien
    Kurzfassung: 〈p 〉The Politics of Third Wave Feminisms provides a comparative analysis of contemporary feminist activism in the US and Britain. Drawing upon in depth research undertaken with activists on both sides of the Atlantic, the book explores contentious themes and debates that have occurred over the past twenty years.
    Anmerkung: Bibliography Seite 220-233 , Description based upon print version of record
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  • 98
    Online-Ressource
    Online-Ressource
    Love, liberation, and escaping slavery : William and Ellen Craft in cultural memory (2015)
    Athens : The University of Georgia Press | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9780820348322
    Sprache: Englisch
    Seiten: 1 Online-Ressource (xiii, 132 Seiten) , Illustrationen
    Serie: A Sarah Mills hodge fund publication
    DDC: 306.3620922
    RVK:
    NW 8295
    RVK:
    NW 2560
    Schlagwort(e): Craft, Ellen ; Craft, William ; Geschichte ; Sklaverei ; Flucht ; USA
    Anmerkung: Literaturverzeichnis: Seite 107-125 , Description based upon print version of record
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  • 99
    Online-Ressource
    Online-Ressource
    D'Holbach's Coterie : An Enlightenment in Paris (2015)
    Princeton : Princeton University Press | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781400869909
    Sprache: Englisch
    Seiten: 1 Online-Ressource (0 pages)
    Serie: Princeton Legacy Library
    DDC: 194
    Kurzfassung: Students of the Enlightenment have long assumed that the major movement towards atheism in the Ancien Régime was centered in the circle of intellectuals who met at the home of Baron d'Holbach during the last half of the eighteenth century. This major critical study shows, contrary to the accepted views, that in fact, atheism was not the common bond of a majority of the members and that, far from being alienated figures, most of the members were privileged and publicly successful citizens devoted to peaceful and gradual reform. Alan Charles Kors determines the coterie's membership and discovers it to have been a diverse assemblage of philosophes, men of letters, and scientists. Analyzing the thought and behavior of those members who lived past 1789, the author argues that the hostility to the Revolution expressed by the coterie's survivors was fully consistent with their world view. Originally published in 1976. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
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  • 100
    Online-Ressource
    Online-Ressource
    The Silent Revolution : Changing Values and Political Styles Among Western Publics (2015)
    Princeton : Princeton University Press | Ann Arbor, Michigan : ProQuest
    Details
    ISBN: 9781400869589
    Sprache: Englisch
    Seiten: 1 Online-Ressource (0 pages)
    Serie: Princeton Legacy Library
    DDC: 306.2
    RVK:
    MG 10086
    RVK:
    MR 7200
    RVK:
    MS 1170
    Schlagwort(e): Europäische Union ; Politischer Wandel ; USA
    Kurzfassung: This book contends that beneath the frenzied activism of the sixties and the seeming quiescence of the seventies, a "silent revolution" has been occurring that is gradually but fundamentally changing political life throughout the Western world. Ronald Inglehart focuses on two aspects of this revolution: a shift from an overwhelming emphasis on material values and physical security toward greater concern with the quality of life; and an increase in the political skills of Western publics that enables them to play a greater role in making important political decisions. Originally published in 1977. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
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