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  • 2015-2019  (342)
  • 1995-1999
  • 2015  (342)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (342)
  • 101
    ISBN: 9782889196791
    Language: English
    Pages: 1 Online-Ressource (283 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances
    Note: English
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  • 102
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196166
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Virtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain enviroment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication
    Note: English
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  • 103
    ISBN: 9782889196432
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field
    Note: English
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  • 104
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195107
    Language: English
    Pages: 1 Online-Ressource (144 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Signaling through the cell surface antigen receptor is a hallmark of various stages of lymphocyte development and adaptive immunity. Besides the adaptive immune system, the innate immunity is equally important for protection. However, the mechanistic connection between signaling, chromatin changes and downstream transcriptional pathways in both innate and adaptive immune system remains incompletely understood in hematopoiesis. A related issue is how the enhancers communicate to the promoters in a stage specific fashion and in the context of chromatin. Because the factors that regulate chromatin are generally present and active in most cell types, how could cell type and/or stage specific chromatin architecture is achieved in response to a particular immune signal?The genetic loci that encode lymphocyte cell surface receptors are in an "unrearranged” or “germline” configuration during the early stages of development. Thus, in addition to expressing lineage and/or stage specific transcription factors during each developmental stage, lymphocytes also need to rearrange their cognate receptor loci in a strictly ordered fashion. Hence, there must be a tightly coordinated communication between the recombination machinery and the transcriptional machinery (including chromatin regulators) at every developmental step. Mature B cells also undergo classswitch recombination and somatic hypermutation. Importantly, along the way, these cells must avoid autoimmune responses and only those cells capable of recognizing foreignantigens are preserved to reach peripheral organs where they must function. The exquisite regulation that govern chromatin accessibility, recombination and transcription regulation in response to the environmental signals in the immune system is discussed here is a series of articles
    Note: English
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  • 105
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194537
    Language: English
    Pages: 1 Online-Ressource (144 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Scientists and clinicians interested in cerebrovascular physiology in humans now have numerous possibilities to monitor, invasively or non-invasively, the oxygenation status of cerebral tissue. Monitoring cerebral oxygenation has several utilities; to improve patient outcome, to better understand the mechanisms underlying orthostatic hypotension; to provide insight into functional neurovascular coupling; to evaluate the influence of vasopressors on cerebral oxygen levels in patients under anesthesia; and to study the limitations of exercise tolerance. This themed research topic, through theoretical and experimental papers, covers new and exciting issues related to the study of cerebral oxygenation in health and disease. This e-book includes manuscripts inclusive of original research, methodologies and reviews in the field of integrative physiology, cognitive testing, orthostatic stress, exercise physiology and anesthesia
    Note: English
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  • 106
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194667
    Language: English
    Pages: 1 Online-Ressource (143 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Most decisions in life are based on incomplete information and have uncertain consequences. To successfully cope with real-life situations, the nervous system has to estimate, represent and eventually resolve uncertainty at various levels. A common tradeoff in such decisions involves those between the magnitude of the expected rewards and the uncertainty of obtaining the rewards. For instance, a decision maker may choose to forgo the high expected rewards of investing in the stock market and settle instead for the lower expected reward and much less uncertainty of a savings account. Little is known about how different forms of uncertainty, such as risk or ambiguity, are processed and learned about and how they are integrated with expected rewards and individual preferences throughout the decision making process. With this Research Topic we aim to provide a deeper and more detailed understanding of the processes behind decision making under uncertainty
    Note: English
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  • 107
    ISBN: 9782889195084
    Language: English
    Pages: 1 Online-Ressource (161 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Have you ever heard of a ...
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  • 108
    ISBN: 9782889195749
    Language: English
    Pages: 1 Online-Ressource (165 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The broad host range pathogenic bacterium Agrobacterium tumefaciens has been widely studied as a model system to understand horizontal gene flow, secretion of effector proteins into host cells, and plant-pathogen interactions. Agrobacterium-mediated plant transformation also is the major method for generating transgenic plants for research and biotechnology purposes. Agrobacterium species have the natural ability to conduct interkingdom genetic transfer from bacteria to eukaryotes, including most plant species, yeast, fungi, and even animal cells. In nature, A. tumefaciens causes crown gall disease resulting from expression in plants of auxin and cytokinin biosynthesis genes encoded by the transferred (T-) DNA. Gene transfer from A. tumefaciens to host cells requires virulence (vir) genes that reside on the resident tumor-inducing (Ti) plasmid. In addition to T-DNA, several Virulence (Vir) effector proteins are also translocated to host cells through a bacterial type IV secretion system. These proteins aid in T-DNA trafficking through the host cell cytoplasm, nuclear targeting, and T-DNA integration. Genes within native T-DNAs can be replaced by any gene of interest, making Agrobacterium species important tools for plant research and genetic engineering. In this research topic, we provided updated information on several important areas of Agrobacterium biology and its use for biotechnology purposes
    Note: English
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  • 109
    ISBN: 9782889195466
    Language: English
    Pages: 1 Online-Ressource (109 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the last three decades, research has extensively focused on the role of Fe and other mineral nutrients in regulating biological processes, ranging from the surface to the deep ocean. This has produced major breakthroughs in our understanding of the fundamental role of those bioactive elements on the carbon, nitrogen and sulfur cycles and ecosystem function. However, biological processes cannot be entirely sustained by that small set of chemical elements, and new scientific evidence suggests that trace metals other than Fe (e.g., Co, Mo and Ni) as well as essential organic growth factors (e.g., vitamins) may also be crucial in most aquatic systems
    Note: English
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  • 110
    ISBN: 9782889196951
    Language: English
    Pages: 1 Online-Ressource (173 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Medical Centre’s and Sanaria's derived chemoprophylaxis with sporozoites vaccines. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria
    Note: English
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  • 111
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195589
    Language: English
    Pages: 1 Online-Ressource (100 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The transmission route used by many bacterial pathogens of clinical importance includes a step outside the host; thereafter refer to as the non-clinical environment (NCE). Obvious examples include foodborne and waterborne pathogens and also pathogens that are transmitted by hands or aerosols. In the NCE, pathogens have to cope with the presence of toxic compounds, sub-optimal temperature, starvation, presence of competitors and predators. Adaptation of bacterial pathogens to such stresses affects their interaction with the host. This Research Topic presents important concept to understand the life of bacterial pathogens in the NCE and provides the reader with an overview of the strategies used by bacterial pathogens to survive and replicate outside the host
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  • 112
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197316
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cardiovascular diseases pose an enormous clinical challenge, remaining the most common cause of death in the world. ß-adrenoceptors play an important role on cardiac, vascular and/or endothelial function at a cellular level with relevant applications in several cardiovascular diseases, such as heart failure and hypertension. G protein– coupled receptors (GPCRs), including ß-adrenergic receptors, constitute the most ubiquitous superfamily of plasma membrane receptors and represent the single most important type of therapeutic drug target. Sympathetic nervous system hyperactivity, which characterizes several cardiovascular diseases, such as heart failure and hypertension, as well as physiological ageing, has been proved to exert in the long-term detrimental effects in a wide range of cardiovascular diseases. Acutely, sympathetic hyperactivity represents the response to an insult to the myocardium, aiming to compensate for decreased cardiac output. This process involves the activation of beta-adrenergic receptors by catecholamine with consequent heart rate and cardiac contractility increase. However, long-term exposure of the heart to elevated norepinephrine and epinephrine levels, originating from sympathetic nerve endings and chromaffin cells of the adrenal gland, results in further progressive deterioration in cardiac structure and function. At the molecular level, sustained sympathetic nervous system hyperactivity is responsible for several alterations including altered beta-adrenergic receptor signaling and function (down-regulation/ desensitization). Moreover, the detrimental effects of catecholamine affect also the function of different cell types including, but not limited to, endothelial cells, fibroblasts and smooth muscle cells. Thus, the success of beta-blocker therapy is due, at least in part, to the protection of the heart and the vasculature from the noxious effects of augmented catecholamine levels. The research topic aimed to support the progress towards understanding the role of sympathetic nervous system under physiological conditions, and the contribution of its hyperactivity in the pathogenesis and progression of cardiovascular diseases
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  • 113
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196043
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This topic covers emerging knowledge about the properties and functions of the outer membranes of chloroplasts and mitochondria. These outer membranes house various processes necessary for efficient communication and thus integration of the organelles with and into their surroundings in the cytoplasm. Such processes include, but are not limited to, protein import, organelle division, organelle movement, metabolism, and metabolite/ion transport. Recent molecular genetic, biochemical and cell biological studies have revealed functions of various outer membrane proteins. These findings have helped address and generate diverse biological and evolutionary questions at molecular, cellular and whole organism levels. The topic should encourage contributions of scientists from various disciplines and thus would provide the field with opportunities to "think outside the box" and to develop potential collaborations. The topic is also aimed to stimulate interests of general audience in the outer membranes of chloroplasts and mitochondria
    Note: English
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  • 114
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195978
    Language: English
    Pages: 1 Online-Ressource (91 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Complex systems are to be seen as typically having multiple levels of organization. For instance, in the behavioural and cognitive sciences, there has been a long lasting trend, promoted by the seminal work of David Marr, putting focus on three distinct levels of analysis: the computational level, accounting for the What and Why issues, the algorithmic and the implementational levels specifying the How problem. However, the tremendous developments in neuroscience knowledge about processes at different scales of organization together with the complexity of today cognitive theories suggest that there will hardly be only three levels of explanation. Instead, there will be many different degrees of commitments corresponding to the different granularities - from high-level (behavioural) models to low-level (neural and molecular) models of the cognitive research program. For instance, Bayesian approaches, that are usually advocated for formalizing Marr's computational level and rational behaviour, have even been adopted to model synaptic plasticity and axon guidance by molecular gradients. As a result, we can consider the behavioural scientist as dealing with models at a multiplicity of levels. The purpose of this Research Topic in Frontiers in Theoretical and Philosophical Psychology is to promote an approach to the role of the levels and explanation and models which is of interest for cognitive scientists, neuroscientists, psychologists, behavioural scientists, and philosophers of science
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  • 115
    ISBN: 9782889194452
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system
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  • 116
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194315
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Organisms are equipped with value systems that signal the salience of environmental cues to their nervous system, causing a change in the nervous system that results in modification of their behavior. These systems are necessary for an organism to adapt its behavior when an important environmental event occurs. A value system constitutes a basic assumption of what is good and bad for an agent. These value systems have been effectively used in robotic systems to shape behavior. For example, many robots have used models of the dopaminergic system to reinforce behavior that leads to rewards. Other modulatory systems that shape behavior are acetylcholine’s effect on attention, norepinephrine’s effect on vigilance, and serotonin’s effect on impulsiveness, mood, and risk. Moreover, hormonal systems such as oxytocin and its effect on trust constitute as a value system. This book presents current research involving neurobiologically inspired robots whose behavior is: 1) Shaped by value and reward learning, 2) adapted through interaction with the environment, and 3) shaped by extracting value from the environment
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  • 117
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196388
    Language: English
    Pages: 1 Online-Ressource (102 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on structural and computational approaches to understanding carbohydrate recognition by proteins involved in immunity and infection. Particular areas of focus include cancer immunotherapeutics, carbohydrate-lectin interactions, glycosylation and glycosyltransferases
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  • 118
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195053
    Language: English
    Pages: 1 Online-Ressource (127 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Telemedicine networks to support healthcare workers in resource-limited settings (often for humanitarian purposes) have evolved over the last decade or so in a largely autonomous way. Communication between them has been informal and relatively limited in scope. This situation could be improved by developing a comprehensive approach to the collection and dissemination of information.A recent review identified seven telemedicine networks, each of which had been in operation for at least five years and which provided store-and-forward telemedicine services to doctors in low- and middle-income countries. These networks provide clinically useful services and improved healthcare access. However, like much of telemedicine, the formal evidence for their cost-effectiveness remains weak.Topics of current research interest therefore include the cost-effectiveness of telemedicine in resource-limited settings. Outcomes data (and methods for gathering it) such as patient quality of life following a telemedicine episode, the knowledge-gain of healthcare staff involved in telemedicine, and staff recruitment and retention in rural areas are also of interest. Finally, there is little published information about the performance of these telemedicine networks (and methods for measuring it), about how best to manage them, and about how to share resources between them.A collection of articles reporting the current evidence supporting the use of telemedicine in resource-limited settings would build the evidence base and should provide a focus for future research. It would also serve to raise the profile of this potentially important research field
    Note: English
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  • 119
    ISBN: 9782889195169
    Language: English
    Pages: 1 Online-Ressource (136 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Prosocial behaviors such ...
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  • 120
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194360
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Endoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. A number of biochemical, physiological, or pathological stimuli can interrupt protein folding process, causing accumulation of unfolded or misfolded proteins in the ER lumen, a condition called “ER stress”. To cope with accumulation of unfolded or misfolded proteins, the ER has evolved a group of signaling pathways termed “Unfolded Protein Response (UPR)” or “ER stress response” to align cellular physiology. To maintain ER homeostasis, transcriptional regulation mediated through multiple UPR branches is orchestrated to increase ER folding capacity, reduce ER workload, and promote degradation of misfolded proteins. In recent years, accumulating evidence suggests that ER stress-triggered transcriptional reprogramming exists in many pathophysiological processes and plays fundamental roles in the initiation and progression of a variety of diseases, such as metabolic disease, cardiovascular disease, neurodegenerative disease, and cancer. Understanding effects and mechanisms of ER stressassociated transcriptional reprogramming has high impact on many areas of molecular genetics and will be particularly informative to the development of pharmacologic avenues towards the prevention and treatment of modern common human diseases by targeting the UPR signaling. For these reasons, ER stress response and transcriptional reprogramming are a timely and necessary topic of discussion for Frontiers in Genetics. The important topics in this area include but not limited to: (1) ER-resident transcription factors and their involvements in ER stress response and cell physiology; (2) Physiologic roles and molecular mechanisms of ER stress-associated transcriptional regulation in lipid and glucose metabolism; (3) In vitro and in vivo models for ER stress-associated transcriptional reprogramming; (4) ER stress-associated transcriptional regulation in human disease; (5) Therapeutic potentials by targeting ER stress response pathways
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  • 121
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    ISBN: 9782889196425
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In 2011, the National Ins ...
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  • 122
    ISBN: 9782889194483
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Viruses infect numerous microorganisms including, predominantly, Bacteria (bacteriophages or phages) but also Archaea, Protists, and Fungi. They are the most abundant and ubiquitous biological entities on Earth and are important drivers of ecosystem functioning. Little is known, however, about the vast majority of these viruses of microorganisms, or VoMs. Modern techniques such as metagenomics have enabled the discovery and description of more presumptive VoMs than ever before, but also have exposed gaps in our understanding of VoM ecology. Exploring the ecology of these viruses – which is how they interact with host organisms, the abiotic environment, larger organisms, and even other viruses across a variety of environments and conditions – is the next frontier. Integration of a growing molecular understanding of VoMs with ecological studies will expand our knowledge of ecosystem dynamics. Ecology can be studied at multiple levels including individual organisms, populations, communities, whole ecosystems, and the entire biosphere. Ecology additionally can consider normal, equilibrium conditions or instead perturbations. Perturbations are of particular interest because measuring the effect of disturbances on VoM-associated communities provides important windows into how VoMs contribute to ecosystem dynamics. These disturbances in turn can be studied through in vitro, in vivo, and in situ experimentation, measuring responses by VoM-associated communities to changes in nutrient availability, stress, physical disruption, seasonality, etc., and could apply to studies at all ecological levels. These are considered here across diverse systems and environments
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  • 123
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    ISBN: 9782889197415
    Language: English
    Pages: 1 Online-Ressource (82 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis
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  • 124
    ISBN: 9782889196135
    Language: English
    Pages: 1 Online-Ressource (314 p.)
    Series Statement: Frontiers Research Topics
    Abstract: What can we learn from sp ...
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  • 125
    ISBN: 9782889196111
    Language: English
    Pages: 1 Online-Ressource (81 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Undergraduate programs in public health are growing rapidly. At colleges and universities throughout the United States, both the number of programs and the number of students have expanded greatly in the past decade. In response to this trend, the Council for Education of Public Health (CEPH) has begun to accredit undergraduate public health programs, with the first programs approved in 2014. Around the country programs exhibit wide variation, from concentrations in liberal arts colleges to pre-clinical foundations at doctorate-granting universities to undergraduate programs in accredited schools of public health. Faculty, both new and seasoned, are fully aware of the need to integrate undergraduate education in public health with graduate education—but the roadmaps of exactly how to do so are still nascent. The purpose of this Research Topic is to gather articles describing this variation, with the intent that the collective body of work will facilitate analysis and discussion of what makes a quality education and builds a competent workforce
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  • 126
    ISBN: 9782889194810
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming
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  • 127
    ISBN: 9782889195114
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Dengue is the most import ...
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  • 128
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    ISBN: 9782889195671
    Language: English
    Pages: 1 Online-Ressource (62 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In 2007, Jeremy Jass proposed a molecular classification of colorectal cancer including KRAS, BRAF, Mismatch Repair, CIMP and MGMT Status. Since then, many prognostic and predictive studies have been published on this topic, mainly focusing on one single molecular marker. The aim of the e-book is to summarize the knowledge in 2014 from a multidisciplinary point of view that can potentially be used as a manual by CRC researchers in every field
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  • 129
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    ISBN: 9782889196746
    Language: English
    Pages: 1 Online-Ressource (201 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field
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  • 130
    ISBN: 9782889195886
    Language: English
    Pages: 1 Online-Ressource (153 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Next Generation Sequencing technologies are increasingly revealing that microbial taxa likely to be parasites or symbionts are probably much more prevalent and diverse than previously thought. Every well studied free-living species has parasites; parasites themselves can be parasitized. As a rule of thumb, there is an estimated 4 parasitic species for any given host, and the better a host is studied the more parasites are known to infect it. Therefore, parasites and other symbionts should represent a very large number of species and may far outnumber those with 'free-living' lifestyles. Paradoxically, free-living hosts, which form the bulk of our knowledge of biology, may be a minority! Microbial parasites typically are characterized by their small size, short generation time, and high rates of reproduction, with simple life cycle occurring generally within a single host. They are diverse and ubiquitous in the environment, comprising viruses, prokaryotes and eukaryotes. This Frontiers Research Topic sought to provide a broad overview but concise, comprehensive, well referenced and up-to-date state of the art for everyone involved with microbial parasites in aquatic microbial ecology
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  • 131
    ISBN: 9782889196999
    Language: English
    Pages: 1 Online-Ressource (68 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Noninvasive brain stimula ...
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  • 132
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    ISBN: 9782889194407
    Language: English
    Pages: 1 Online-Ressource (115 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction
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  • 133
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    ISBN: 9782889195213
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Series Statement: Frontiers Research Topics
    Abstract: It becomes increasingly clear that the basis of antibiotic resistance problem among bacterial pathogens is not confined to the borders of clinical microbiology but has broader ecological and evolutionary associations. This Research Topic “Role and prevalence of antibiosis and the related resistance genes in the environment” in Frontiers in Microbiology, section Antimicrobials, Resistance and Chemotherapy, presents the examples of occurrence and diversity of antibiotic resistance genes in the wide range of environments, from the grasslands of the Colombian Andes, to the dairy farms and small animal veterinary hospitals in the United Stated, and to the various environments of Continental Europe and Indochina. Besides, various genetic mechanisms and selection/co-selection factors contributing to the dissemination and maintenance of antibiotic resistance genes are presented. The topic is finalized by the mathematical modeling approach to access the probability of rare horizontal gene transfer events in bacterial populations
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  • 134
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    ISBN: 9782889194476
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Series Statement: Frontiers Research Topics
    Abstract: When faced with a difficult task, people often look at the sky or close their eyes. This behavior is functional: the reduction of distractions in the environment can improve performance on cognitive tasks, including memory retrieval. Reduction of visual distractions can be operationalized through eye-closure, gaze aversion, or by comparing exposure to simple and complex visual displays, respectively. Reduction of auditory distractions is typically examined by comparing performance under quiet and noisy conditions. Theoretical reasoning regarding this phenomenon draws on various psychological principles, including embodied cognition, cognitive load, and modality-specific interference. Practical applications of the research topic are diverse. For example, the findings could be used to improve performance in forensic settings (e.g., eyewitness testimony), educational settings (e.g., exam performance), occupational settings (e.g., employee productivity), or medical settings (e.g., medical history reporting). This Research Topic welcomes articles from all areas of psychology relating to the reduction of distractions to improve task performance. Articles can address (but are not limited to) new empirical findings, comprehensive reviews, theoretical frameworks, opinion pieces, or discussions of practical applications
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  • 135
    ISBN: 9782889195701
    Language: English
    Pages: 1 Online-Ressource (264 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The Halophiles 2013 meeting is a multidisciplinary international congress, with a strong history of regular triennial meetings since 1978. Our mission is to bring researchers from a wide diversity of investigation interests (e.g., protein and species evolution; niche adaptation, ecology, taxonomy, genomics, metagenomics, horizontal gene transfer, gene regulation; DNA replication, repair and recombination; signal transduction; community assembly and species distribution; astrobiology; biotechnological applications; adaptation to radiation, desiccation, osmotic stress) into a single forum for the integration and synthesis of ideas and data from all three domains of life, and their viruses, yet from a single environment; salt concentrations greater than seawater. This cross-section of research informs our understanding of the microbiological world in many ways. The halophilic environment is extreme, especially above 10% NaCl, restricting life solely to microbes. The microorganisms that live there are adapted to extreme conditions, and are notable for their ability to survive high doses of radiation and desiccation. Therefore, the hypersaline environment is a model system (both the abiotic, and biologic factors) for insightful understanding regarding conditions and life in the absence of plant and animals (e.g., life on the early earth, and other solar system bodies like Mars and Europa). Lower salinity conditions (e.g., 6-10% NaCl) form luxuriant microbial mats considered modern analogues of fossilized stromatolites, which are enormous microbially produced structures fashioned during the Precambrian (and still seen today in places like Shark’s Bay, Australia). Hypersaline systems are island-like habitats spread patchily across the earth’s surface, and similar to the Galapagos Islands represent unique systems excellent for studying the evolutionary pressures that shape microbial community assembly, adaptation, and speciation. The unique adaptations to this extreme environment produce valuable proteins, enzymes and other molecules capable of remediating harsh human instigated environments, and are useful for the production of biofuels, vitamins, and retinal implants, for example. This research topic is intended to capture the breadth and depth of these topics
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  • 136
    ISBN: 9782889194964
    Language: English
    Pages: 1 Online-Ressource (159 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic potential of a cell is increased leading to the initiation and/or progression of tumourigenesis. Moreover, these genetic defects can increase or contribute to resistance to chemotherapeutic agents and/or radiotherapy. Modulating the outcome of cellular stress responses towards cell death in tumour cells without affecting surrounding normal cells is thus one of the ultimate aims in the development of new cancer therapeutics. To achieve this aim, a detailed understanding of cellular stress response pathways and their aberrations in cancer is required.This Research topic aims to reflect the broadness and complexity of this important area of cancer research
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  • 137
    ISBN: 9782889196296
    Language: English
    Pages: 1 Online-Ressource (74 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IFN-I could serve as a double edge sword, either containing an infection or enhancing susceptibility. For example, IFN-I, which is essential for early containment of viral infections, has been shown to be detrimental to the host during bacterial infections. In fact, recent significant reports have shown that influenza virus induced IFN-I responses can enhance the host susceptibility to secondary bacterial infections. These recent reports highlight the expanding immunoregulatory role of IFN-I in the host immunity. With these recent findings in mind, the aim of this research topic is to welcome novel data, opinion and literature reviews on the newly identified dual functions of IFN-I. This research topic wills focus on the following areas of IFN-I: 1) a detrimental role of IFN-I during primary bacterial infection; 2) a detrimental role of viral infection induced IFN-I during secondary bacterial infections; 3) evolutionary pressure that drove detrimental IFN-I response during primary bacterial infection; and 4) does benefit of IFN-I responses during primary viral infections outweigh the adverse consequences of IFN-I mediated enhanced susceptibility to secondary bacterial infections
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  • 138
    ISBN: 9782889196760
    Language: English
    Pages: 1 Online-Ressource (194 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease
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  • 139
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    ISBN: 9782889193943
    Language: English
    Pages: 1 Online-Ressource (95 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. This e-Book "PAIN - Novel targets and new technologies" has brought together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies across the various types of pain. This information is presented as novel research findings, short communications and review articles. The goal of this e-Book is to generate further collaborative discussion on the future and direction of pain therapies
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  • 140
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    ISBN: 9782889195626
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Frontiers in Psychology is introducing a new research topic, Pedagogical Psychology: Beyond the 21st Century, which will be released as an online journal issue in summer 2014. The purpose of Beyond the 21st Century will be to publish goal- oriented articles leading to improvement of teaching and learning at all levels of psychology education. Until perhaps 20 years ago, educational approaches to teaching were largely informed by a “Stand and Deliver” pedagogical attitude. The psychology of this approach has often invested unrealistic and unrealizable responsibilities in both teachers and students. With the emergence of electronic data sharing (e.g., the Internet) and global cooperation/competition, newer approaches to teaching have begun to supplement and sometimes replace the older model of teaching. These newer approaches have simultaneously taken advantage of technological advances, global changes, and an evolving understanding of successful student-mentor relationships. As the pedagogical models driven by these changes evolve into the 22nd century and beyond, what seems groundbreaking today will, in hindsight, be seen as hidebound. Thus, the major goal of Beyond the 21st Century will be to publish manuscripts which imaginatively, but realistically anticipate future trends in teaching undergraduate psychology
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  • 141
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    ISBN: 9782889196982
    Language: English
    Pages: 1 Online-Ressource (62 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology
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  • 142
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    ISBN: 9782889193905
    Language: English
    Pages: 1 Online-Ressource (87 p.)
    Series Statement: Frontiers Research Topics
    Abstract: We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing
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  • 143
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    ISBN: 9782889196678
    Language: English
    Pages: 1 Online-Ressource (231 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There seems little doubt ...
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  • 144
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    ISBN: 9782889194643
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell
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  • 145
    ISBN: 9782889195831
    Language: English
    Pages: 1 Online-Ressource (201 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Researchers working in many fields of psychology and neuroscience are interested in the temporal structure of experience, as well as the experience of time, at scales of a few milliseconds up to a few seconds as well as days, months, years, and beyond. This Research Topic supposes that broadly speaking, the field of "time psychology" can be organized by distinguishing between "perceptual" and "conceptual" time-scales. Dealing with conceptual time: "mental time travel," also called mental simulation, self-projection, episodic-semantic memory, prospection/foresight, allows humans (and perhaps other animals) to imagine and plan events and experiences in their personal futures, based in large part on memories of their personal pasts, as well as general knowledge. Moreover, contents of human language and thought are fundamentally organized by a temporal dimension, enmeshed with it so thoroughly that it is usually expressible only through spatial metaphors. But what might such notions have to do with experienced durations of events lasting milliseconds up to a few seconds, during the so-called "present moment" of perception-action cycle time? This Research Topic is organized around the general premise that, by considering how mental time travel might "scale down" to time perception (and vice-versa, no less), progress and integrative synthesis within- and across- scientific domains might be facilitated. Bipolar configurations of future- and past-orientations of the self may be repeated in parallel across conceptual and perceptual time-scales, subsumed by a general "Janus-like" feedforward-feedback system for goal-pursuit. As an example, it is notable that the duality of "prospection" and semantic-episodic memory operating at conceptual time-scales has an analogue in perception-action cycle time, namely the interplay of anticipatory attention and working memory. Authors from all areas of psychology and neuroscience are encouraged to submit articles of any format accepted by the journal (Original Research, Methods, Hypothesis & Theory, Reviews, etc.), which might speak to questions about time and temporal phenomena at long and/or short time-scales
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  • 146
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    ISBN: 9782889194872
    Language: English
    Pages: 1 Online-Ressource (188 p.)
    Series Statement: Frontiers Research Topics
    Abstract: While most natural languages rely on speech, humans can spontaneously generate comparable linguistic systems that utilize manual gestures. This collection of papers examines the interaction between natural language and its phonetic vessels - human speech or manual gestures. We seek to identify what linguistic aspects are invariant across signed and spoken languages, and determine how the choice of the phonetic vessel shapes language structure, its processing and its neural implementation. We welcome rigorous empirical studies from a wide variety of perspectives, ranging from behavioral studies to brain analyses, diverse ages (from infants to adults), and multiple languages - both conventional and emerging home signs and sign languages
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  • 147
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    ISBN: 9782889195794
    Language: English
    Pages: 1 Online-Ressource (173 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Synaesthesia is a condition in which a stimulus elicits an additional subjective experience. For example, the letter E printed in black (the inducer) may trigger an additional colour experience as a concurrent (e.g., blue). Synaesthesia tends to run in families and thus, a genetic component is likely. However, given that the stimuli that typically induce synaesthesia are cultural artefacts, a learning component must also be involved. Moreover, there is evidence that synaesthetic experiences not only activate brain areas typically involved in processing sensory input of the concurrent modality; synaesthesia seems to cause a structural reorganisation of the brain. Attempts to train non-synaesthetes with synaesthetic associations have been successful in mimicking certain behavioural aspects and posthypnotic induction of synaesthetic experiences in non-synaesthetes has even led to the according phenomenological reports. These latter findings suggest that structural brain reorganization may not be a critical precondition, but rather a consequence of the sustained coupling of inducers and concurrents. Interestingly, synaesthetes seem to be able to easily transfer synaesthetic experiences to novel stimuli. Beyond this, certain drugs (e.g., LSD) can lead to synaesthesia-like experiences and may provide additional insights into the neurobiological basis of the condition. Furthermore, brain damage can both lead to a sudden presence of synaesthetic experiences in previously non-synaesthetic individuals and a sudden absence of synaesthesia in previously synaesthetic individuals. Moreover, enduring sensory substitution has been effective in inducing a kind of acquired synaesthesia. Besides informing us about the cognitive mechanisms of synaesthesia, synaesthesia research is relevant for more general questions, for example about consciousness such as the binding problem, about crossmodal correspondences and about how individual differences in perceiving and experiencing the world develop. Hence the aim of the current Research Topic is to provide novel insights into the development of synaesthesia both in its genuine and acquired form. We welcome novel experimental work and theoretical contributions (e.g., review and opinion articles) focussing on factors such as brain maturation, learning, training, hypnosis, drugs, sensory substitution and brain damage and their relation to the development of any form of synaesthesia
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  • 148
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    ISBN: 9782889195411
    Language: English
    Pages: 1 Online-Ressource (125 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cognitive processing is commonly conceptualized as being restricted to the cerebral cortex. Accordingly, electrophysiology, neuroimaging and lesion studies involving human and animal subjects have almost exclusively focused on defining roles for cerebral cortical areas in cognition. Roles for the thalamus in cognition have been largely ignored despite the fact that the extensive connectivity between the thalamus and cerebral cortex gives rise to a closely coupled thalamo-cortical system. However, in recent years, growing interest in the thalamus as much more than a passive sensory structure, as well as methodological advances such as high-resolution functional magnetic resonance imaging of the thalamus and improved electrode targeting to subregions of thalamic nuclei using electrical stimulation and diffusion tensor imaging, have fostered research into thalamic contributions to cognition. Evidence suggests that behavioral context modulates processing in primary sensory, or first-order, thalamic nuclei (for example, the lateral geniculate and ventral posterior nuclei), allowing attentional filtering of incoming sensory information at an early stage of brain processing. Behavioral context appears to more strongly influence higher-order thalamic nuclei (for example, the pulvinar and mediodorsal nucleus), which receive major input from the cortex rather than the sensory periphery. Such higher-order thalamic nuclei have been shown to regulate information transmission in frontal and higher-order sensory cortex according to cognitive demands. This Research Topic aims to bring together neuroscientists who study different parts of the thalamus, particularly thalamic nuclei other than the primary sensory relays, and highlight the thalamic contributions to attention, memory, reward processing, decision-making, and language. By doing so, an emphasis is also placed on neural mechanisms common to many, if not all, of these cognitive operations, such as thalamo-cortical interactions and modulatory influences from sources in the brainstem and basal ganglia. The overall view that emerges is that the thalamus is a vital node in brain networks supporting cognition
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  • 149
    ISBN: 9782889196395
    Language: English
    Pages: 1 Online-Ressource (150 p.)
    Series Statement: Frontiers Research Topics
    Abstract: It is largely accepted in the relevant literature that successful learning of one or more non-native languages is affected by a number of factors that are independent of the target language(s) per se; these factors include the age of acquisition (AoA) of the target language(s), the type and amount of formal instruction the learners have received, as well as the amount of language use that the learners demonstrate. Recent experimental evidence suggests that one crucial factor for efficient native-like performance in the non-native language is the amount of naturalistic exposure, or immersion, that the learners receive to that language. This can be broadly defined as the degree to which language learners use their non-native language outside the classroom and for their day-to-day activities, and usually presupposes that the learners live in an environment where their non-native language is exclusively or mostly used. Existing literature has suggested that linguistic immersion can be beneficial for lexical and semantic acquisition in a non-native language, as well as for non-native morphological and syntactic processing. More recent evidence has also suggested that naturalistic learning of a non-native language can also have an impact on the patterns of brain activity underlying language processing, as well as on the structure of brain regions that are involved, expressed as changes in the grey matter structure. This Research Topic brings together studies on the effects of learning and speaking a non-native language in a naturalistic environment. These include more efficient or “native-like” processing in behavioural tasks tapping on language (lexicon, morphology, syntax), as well as changes in the brain structure and function, as revealed by neuroimaging studies
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  • 150
    ISBN: 9782889196012
    Language: English
    Pages: 1 Online-Ressource (73 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In multicellular organism ...
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  • 151
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    ISBN: 9782889195954
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases. As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases. In addition, it has long been known that GSH is capable of forming disulfide bonds with cysteine residues of proteins, and the relevance of this mechanism ("S-glutathionylation") in regulation of protein function has been well documented in a number of research fields. Rather paradoxically, it has also been highlighted that GSH—and notably its catabolites, as originated by metabolism by gamma-glutamyltransferase—can promote oxidative processes, by participating in metal ion-mediated reactions eventually leading to formation of reactive oxygen species and free radicals. Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO). The significance of GSH as a major factor in regulation of cell life, proliferation, and death, can be regarded as the integrated result of all these roles, as well as of more which are emerging in diverse fields of biology and pathophysiology. Against this background, modulation of GSH levels and GSH-related enzyme activities represents a fertile field for experimental pharmacology in numerous and diverse perspectives of animal, plant and microbiologic research. This research topic includes 14 articles, i.e. 4 Opinion Articles, 6 Reviews, and 4 Original Research Articles. The contributions by several distinguished research groups, each from his own standpoint of competence and expertise, provide a comprehensive and updated view over the diverse roles, the changing faces of GSH and GSH-related enzymes in cell’s health, disease and death
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  • 152
    ISBN: 9782889195879
    Language: English
    Pages: 1 Online-Ressource (111 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Epigenetics is defined as ...
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  • 153
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    ISBN: 9782889193929
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the history of neuroscience it had long been a virtually axiomatic belief that the mature mammalian nervous system was hardwired and fixed. This view goes back to the work of Louis Broca in the 1850s and has been perhaps most famously articulated by Ramon y Cajal. The immature nervous system was thought to have considerable plasticity, but after maturity the CNS was not considered to be capable of repairing itself after damage. In the last two decades, however, persuasive evidence has been accumulating at an increasing rate that the plasticity of the nervous system persists throughout the lifespan. Beginning 14 years ago, an efficacious form of neurorehabilitation termed Constraint-Induced Movement therapy or CI therapy was shown to produce marked neuroplastic changes in the brain. It has been proposed that CI therapy harnesses neuroplasticity in the service of restoring motor and language function lost as a result of such injuries to the central nervous system as stroke, traumatic brain injury, and cerebral palsy. The proposed journal issue will include articles by the main investigators involved in the development of this body of research. There will also be articles on the role of neurogenesis in the recovery of function after CNS damage encouraged by the stimulation of endogenous stem cell production, exogenous stem cell implantation, and pharmacological means. There will also be two articles describing the work carried out to date on the use of Transcranial Magnetic Stimulation (TMS) and Transcranial Electrical Stimulation (TDCS) to increase the excitability of the brain in order to enhance the recovery of function after stroke
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  • 154
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    ISBN: 9782889194544
    Language: English
    Pages: 1 Online-Ressource (182 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems
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  • 155
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    ISBN: 9782889196029
    Language: English
    Pages: 1 Online-Ressource (181 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives
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  • 156
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    ISBN: 9782889195732
    Language: English
    Pages: 1 Online-Ressource (114 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Women drinking during pre ...
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  • 157
    ISBN: 9782889195633
    Language: English
    Pages: 1 Online-Ressource (111 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Members of the genus Staphylococcus and Streptococcus are the causative agnets of many human and animal diseases. Over the past decade the complete sequencing of many staphylococcal and streptococcal genomes has promoted a significant advance in our knowledge of these important pathogens. The pathogenicity of these bacteria is due to the expression of a large variety of virulence factors. Such determinants, which are cell wall-associated and secreted proteins, include adhesins that confer to the pathogen the ability to attach to extracellular matrix/plasma and host cell surfaces, proteins that contribute to host cell invasion and intracellular survival and soluble factors that decrease phagocytosis and modulate the immune response. Furthermore, these Gram-positive cocci in many natural environments (heart valve, lung, oral cavity, throat) and infections on implanted devices live in matrix-encased groups known as biofilms. Biofilms are specialized bacterial communities with high order organization analogous to that of a tissue in multicellular organism that adhere to abiotic or biological substrata and produce an exopolymeric matrix composed of polysaccarides, proteins, DNA or combination thereof. Bacteria within a biofilm persist in adverse conditions, show resistance to killing by antibiotics and to host immune defences and are difficult to eradicate and treat clinically. Therefore, understanding the mechanisms of biofilm development will allow us to effectively combat staphylococcal/streptococcal biofilm-based infections. This Research Topic will focus on the molecular components involved in biofilm formation by staphylococci and streptococci, the role they play in the development, maturation and dispersal of biofilm and on the regulatory aspects of such complex processes. The implication for the pathogenesis of infective diseases and potential therapeutic strategies against biofilm-based infections will be also discussed. The articles will highlight both the recent advances and future challenges inherent in this rapidly evolving area
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  • 158
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    ISBN: 9782889195565
    Language: English
    Pages: 1 Online-Ressource (154 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection. Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large. This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis
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  • 159
    ISBN: 9782889196869
    Language: English
    Pages: 1 Online-Ressource (154 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The deterioration of skel ...
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  • 160
    ISBN: 9782889195121
    Language: English
    Pages: 1 Online-Ressource (155 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life.CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry. CP may be viewed as aberrant plasticity in response to a lesion, indeed, abnormalities in movement are subtle at first but develop subsequently. It is misleading to suppose that developmental mechanisms are self-reparative. The challenge is to understand activitydependent fine tuning of neural circuitry during normal development and to find how to promote desirable plasticity whilst limiting undesirable effects following developmental lesions. However, before proposing interventions, we have to develop our ability to predict the severity of neonatal insults.We solicited a variety of articles, including long and short reviews, original research and opinion pieces, from both basic scientists and clinicians. Likewise we, as editors, have complementary knowledge and experience in this area. Anna Basu is an academic pediatric neurologist and Gavin Clowry is a developmental neuroscientist
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  • 161
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    ISBN: 9782889195329
    Language: English
    Pages: 1 Online-Ressource (155 p.)
    Series Statement: Frontiers Research Topics
    Abstract: We intuitively believe th ...
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  • 162
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    ISBN: 9782889193653
    Language: English
    Pages: 1 Online-Ressource (214 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The plasticity of the living matter of our nervous system, in short, is the reason why we do a thing with difficulty the first time, but soon do it more and more easily, and finally, with sufficient practice, do it semi-mechanically, or with hardly any consciousness at all. William James, 1899. It is over 100 years since James described the acquisition of skill. How much, or how little, have recent advances in science changed the way we think about skill learning? What theories and ideas do we still hold dear and which have we discarded? Advances in neuroimaging over the past 20 years have provided insight into the dynamic neural processes underlying human motor skill acquisition, focusing primarily on brain networks that are engaged during early versus late stages of learning. What has been challenging for the field is to tightly link these shifting neural processes with what is known about measureable behavioral changes and strategic processes that occur during learning. The complex nature of behavior and strategy in motor learning often result in a trade-off between experimental control and external validity. The articles assembled for this special issue cut across a number of related disciplines and investigate skill learning across multiple domains. The broad range of theoretical, analytical and methodological approaches offer complementary approaches that can be exploited to develop integrated models of skilled learning. It is our hope that this collection inspires innovation and collaboration amongst researchers, and thereby, accelerates development of societally relevant translational paradigms
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  • 163
    ISBN: 9782889194629
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Habituation describes the ...
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  • 164
    ISBN: 9782889194278
    Language: English
    Pages: 1 Online-Ressource (237 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Biophysical modelling of brain activity has a long and illustrious history and has recently profited from technological advances that furnish neuroimaging data at an unprecedented spatiotemporal resolution. Neuronal modelling is a very active area of research, with applications ranging from the characterization of neurobiological and cognitive processes, to constructing artificial brains in silico and building brain-machine interface and neuroprosthetic devices. Biophysical modelling has always benefited from interdisciplinary interactions between different and seemingly distant fields; ranging from mathematics and engineering to linguistics and psychology. This Research Topic aims to promote such interactions by promoting papers that contribute to a deeper understanding of neural activity as measured by fMRI or electrophysiology. In general, mean field models of neural activity can be divided into two classes: neural mass and neural field models. The main difference between these classes is that field models prescribe how a quantity characterizing neural activity (such as average depolarization of a neural population) evolves over both space and time as opposed to mass models, which characterize activity over time only; by assuming that all neurons in a population are located at (approximately) the same point. This Research Topic focuses on both classes of models and considers several aspects and their relative merits that: span from synapses to the whole brain; comparisons of their predictions with EEG and MEG spectra of spontaneous brain activity; evoked responses, seizures, and fitting data - to infer brain states and map physiological parameters
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  • 165
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    ISBN: 9782889196890
    Language: English
    Pages: 1 Online-Ressource (199 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This research topic aims ...
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  • 166
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    ISBN: 9782889194322
    Language: English
    Pages: 1 Online-Ressource (188 p.)
    Series Statement: Frontiers Research Topics
    Abstract: For several decades, theory and research has drawn links between dopaminergic neurotransmission and various aspects of personality and individual differences, as well as major personality processes. Recent increases in the availability and affordability of neuroscience methods have permitted thorough investigation of such links as part of the thriving field of personality neuroscience. However, the picture emerging from this body of research is somewhat puzzling; Rather than being linked to only a few converging dimensions of individual differences in psychological functioning, dopamine seems to be associated with a wide range of rather disparate traits and psychopathological conditions including (among various others) impulsivity, extraversion, anxiety, reward sensitivity, approach behaviour, achievement motivation, working memory performance, cognitive flexibility, depression, anhedonia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Empirical research in this area typically focuses on only one piece of this puzzle based on a specific strand of theory and a narrow section of relevant prior findings. The present research topic will, for the first time, attempt to provide a fairly complete picture of the whole puzzle including all its disparate parts. Contributors will therefore be explicitly encouraged to go beyond their own specific dopamine-personality hypotheses and place their work in a broader context, thereby helping to forge links between largely non-overlapping research traditions
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  • 167
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    ISBN: 9782889194858
    Language: English
    Pages: 1 Online-Ressource (135 p.)
    Series Statement: Frontiers Research Topics
    Abstract: So-called altered states ...
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  • 168
    ISBN: 9782889194384
    Language: English
    Pages: 1 Online-Ressource (740 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Emotion can impact variou ...
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  • 169
    ISBN: 9782889194728
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches
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  • 170
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    ISBN: 9782889194506
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity
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  • 171
    ISBN: 9782889195992
    Language: English
    Pages: 1 Online-Ressource (130 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here
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  • 172
    ISBN: 9782889195442
    Language: English
    Pages: 1 Online-Ressource (113 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs
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  • 173
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    ISBN: 9782889196562
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Learning to read, and to spell are two of the most important cultural skills that must be acquired by children, and for that matter, anyone learning a second language. We are not born with an innate ability to read. A reading system of mental representations that enables us to read must be formed in the brain. Learning to read in alphabetic orthographies is the acquisition of such a system, which links mental representations of visual symbols (letters) in print words, with pre-existing phonological (sound) and semantic (comprehension) cognitive systems for language. Although spelling draws on the same representational knowledge base and is usually correlated with reading, the acquisition processes involved are not quite the same. Spelling requires the sequential production of letters in words, and at beginning levels there may not be a full degree of integration of phonology with its representation by the orthography. Reading, on the other hand, requires only the recognition of a word for pronunciation. Hence, spelling is more difficult than reading, and learning to spell may necessitate more complete representations, or more conscious access to them. The learning processes that children use to acquire such cognitive systems in the brain, and whether these same processes are universal across different languages and orthographies are central theoretical questions. Most children learn to read and spell their language at the same time, thus the co-ordination of these two facets of literacy acquisition needs explication, as well as the effect of different teaching approaches on acquisition. Lack of progress in either reading and/or spelling is also a major issue of concern for parents and teachers necessitating a cross-disciplinary approach to the problem, encompassing major efforts from researchers in neuroscience, cognitive science, experimental psychology, and education. The purpose of this Research Topic is to summarize and review what has been accomplished so far, and to further explore these general issues. Contributions from different perspectives are welcomed and could include theoretical, computational, and empirical works that focus on the acquisition of literacy, including cross-orthographic research
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  • 174
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    ISBN: 9782889195862
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Glycolysis, the pathway of enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate, was elucidated in 1940. For more than seven decades, it has been taught precisely the way its sequence was proposed by Embden, Meyerhof and Parnas. Accordingly, two outcomes of this pathway were proposed, an aerobic glycolysis, with pyruvate as its final product, and an anaerobic glycolysis, identical to the aerobic one, except for an additional reaction, where pyruvate is reduced to lactate. Several studies in the 1980s have shown that both muscle and brain tissues can oxidize and utilize lactate as an energy substrate, challenging this monocarboxylate’s reputation as a useless end-product of anaerobic glycolysis. These findings were met with great skepticism about the idea that lactate could be playing a role in bioenergetics. In the past quarter of a century monocarboxylate transporters (MCTs) were identified and localized in both cellular and mitochondrial membranes. A lactate receptor has been identified. Direct and indirect evidence now indicate that the enzyme lactate dehydrogenase (LDH) resides not only in the cytosol, as part of the glycolytic pathway machinery, but also in the mitochondrial outer membrane. The mitochondrial form of the enzyme oxidizes lactate to pyruvate and concomitantly produces the reducing agent NADH. These findings have shed light on a major drawback of the originally proposed aerobic version of the glycolytic pathway i.e., its inability to regenerate NAD+, as opposed to anaerobic glycolysis that features the cyclical ability of regenerating NAD+ upon pyruvate reduction to lactate by the cytosolic form of LDH. The malate-aspartate shuttle (MAS), a major redox shuttle in the brain, was proposed as an alternative pathway for NAD+ generation for aerobic glycolysis. Nonetheless, would MAS really be necessary for that function if glycolysis always proceeds to the end-products, lactate and NAD+? An additional dilemma the originally proposed aerobic glycolysis presents has to do with the glycolytic pathway of erythrocytes, which despite its highly aerobic environment, always produces lactate as its end-product. It is time to reexamine the original, dogmatic separation of glycolysis into two distinct pathways and put to test the hypothesis of a unified, singular pathway, the end-product of which is lactate, the real substrate of the mitochondrial TCA cycle
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  • 175
    ISBN: 9782889195046
    Language: English
    Pages: 1 Online-Ressource (77 p.)
    Series Statement: Frontiers Research Topics
    Abstract: ATP is normally regarded ...
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  • 176
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    ISBN: 9782889195947
    Language: English
    Pages: 1 Online-Ressource (151 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The visual system consists of hierarchically organized distinct anatomical areas functionally specialized for processing different aspects of a visual object (Felleman & Van Essen, 1991). These visual areas are interconnected through ascending feedforward projections, descending feedback projections, and projections from neural structures at the same hierarchical level (Lamme et al., 1998). Accumulating evidence from anatomical, functional and theoretical studies suggests that these three projections play fundamentally different roles in perception. However, their distinct functional roles in visual processing are still subject to debate (Lamme & Roelfsema, 2000). The focus of this Research Topic is the roles of feedforward and feedback projections in vision. Even though the notions of feedforward, feedback, and reentrant processing are widely accepted, it has been found difficult to distinguish their individual roles on the basis of a single criterion. We welcome empirical contributions, theoretical contributions and reviews that fit into any one (or a combination) of the following domains: 1) their functional roles for perception of specific features of a visual object 2) their contributions to the distinct modes of visual processing (e.g., pre-attentive vs. attentive, conscious vs. unconscious) 3) recent techniques/methodologies to identify distinct functional roles of feedforward and feedback projections and corresponding neural signatures. We believe that the current Research Topic will not only provide recent information about feedforward/feedback processes in vision but also contribute to the understanding fundamental principles of cortical processing in general
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  • 177
    ISBN: 9782889196623
    Language: English
    Pages: 1 Online-Ressource (77 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies
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  • 178
    ISBN: 9782889196531
    Language: English
    Pages: 1 Online-Ressource (93 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Psychiatric symptoms are considered to be distributed along a continuum, from good mental health to a diagnosable psychiatric disorder. In the case of psychosis, subclinical psychotic experiences, which can include odd behaviors, strange speech, unusual perceptual experiences and social/emotional withdrawal, are often referred to as schizotypy. Research examining schizotypal traits in non-clinical populations is rapidly expanding. The exploration of schizotypy allows us to identify areas of overlap with psychiatric disorders (schizophrenia and related disorders) at genetic, biological, environmental and psychosocial levels, thus identifying putative risk factors, as well as exploring potentially protective factors. Schizotypy is also a valuable model for exploring cognition as performance is not confounded by issues often present in schizophrenia samples, such as long-term antipsychotic medication usage, social isolation, and recurrent hospitalizations. Investigating cognition is a particularly important area of research as cognitive symptoms in schizophrenia, such as impaired attention, reduced memory and difficulties with executive functions, are a core feature of schizophrenia and strongly related to quality of life and functional outcomes, yet generally respond poorly to current treatment options. The aim of this special Research Topic is to explore the relationship between cognition, schizotypy and the schizophrenia spectrum. The articles in this e-book draw on a variety of perspectives and represent an interesting array of opinions, reviews and empirical studies that begin to answer questions about the similarities and overlaps between schizotypy and schizophrenia spectrum disorders, contributing to our understanding of potential risk factors. Equally important is research that highlights differences between schizotypy and schizophrenia spectrum disorders that may enhance our understanding of potentially protective or adaptive features of schizotypy. Collectively, these articles highlight the exploratory potential of the study of schizotypy, particularly in relation to better understanding cognition across the schizophrenia spectrum
    Note: English
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  • 179
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    ISBN: 9782889194551
    Language: English
    Pages: 1 Online-Ressource (146 p.)
    Series Statement: Frontiers Research Topics
    Abstract: DNA polymerases are core tools for molecular biology including PCR, whole genome amplification, DNA sequencing and genotyping. Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of new replication assays. These studies have accelerated DNA polymerase engineering for biotechnology. For example, DNA polymerases have been engineered for increased speed and fidelity in PCR while lowering amplification sequence bias. Inhibitor resistant DNA polymerase variants enable PCR directly from tissue (i.e. blood). Design of DNA polymerases that efficiently incorporate modified nucleotide have been critical for development of next generation DNA sequencing, synthetic biology and other labeling and detection technologies. The Frontiers in Microbiology Research Topic on DNA polymerases in Biotechnology aims to capture current research on DNA polymerases and their use in emerging technologies
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  • 180
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    ISBN: 9782889195398
    Language: English
    Pages: 1 Online-Ressource (86 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites
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  • 181
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    ISBN: 9782889194940
    Language: English
    Pages: 1 Online-Ressource (120 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes
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  • 182
    ISBN: 9782889196449
    Language: English
    Pages: 1 Online-Ressource (151 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease. In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes to molecules involved in aging. Oxidative stress takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies
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  • 183
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    ISBN: 9782889195237
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Attachment theory, assessment and research offers a broad, far-reaching view of human functioning, and it can enrich a psychologist's understanding of subjects and their relational adjustment, both in clinical and non-clinical settings. Ongoing research in attachment has led to a number of individual treatments and prevention and intervention programs. The assessment of an individual's attachment organization, can play a crucial role in explaining and previewing the unfolding treatment, the relational adjustments or concerns, and the psychological well-being. We hope to receive empirical papers that give evidence for the usefulness of attachment assessment in both clinical (e.g., patients with Eating Disorder; or Axis-II; psychotherapy patients…) or not clinical population (e.g. Adoptive and/or foster families or couples, Mother-infant assessment in prevention field…). These papers should include methodological issues and information about the participants, the methods used to assess attachment, the process of scorer training and the availability of the manual used to obtain inter-scorer reliability. Case studies may be of interest to the extent that they demonstrate the value of a systematic approach to attachment material. A range of theoretical perspectives is welcome as well presentation of new emergent tools on attachment. Because Frontiers in Psychology is an international journal, each empirical paper should comment on the international implications of the findings and discuss its cross-cultural use. Such comments may include, for example, its linguistic specificity, its robustness in translation, and the cross-cultural generalizability of the constructs and behaviors of the measure and its usual correlates. Cross-cultural generalizability is not, however, a requirement
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  • 184
    ISBN: 9782889196074
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There is extensive eviden ...
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  • 185
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    ISBN: 9782889196258
    Language: English
    Pages: 1 Online-Ressource (93 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Carbohydrates are extremely abundant bio-molecules; they are on all mammalian cell surfaces as well as on bacterial cell surfaces. In mammals most secreted proteins are glycosylated, with the glycan component comprising a significant amount by mass of the glycoprotein. Although, many years ago carbohydrate-protein recognition events were demonstrated as involved in invertebrate self-non self recognition, the contribution of carbohydrate-protein binding events to the mechanisms of the mammalian immune response was not embraced with the same enthusiasm. Adaptive immunity and the contribution of antibodies, T cells and T-lymphocyte sub-sets and protein antigen presentation dominated immunological theory. Unlike protein structures, carbohydrate structures are not template driven yet the numerous enzymes involved in carbohydrate biosynthesis and modification are encoded by a major component of the genome, and the expression of these enzymes is tightly regulated. As a consequence carbohydrate structures are also regulated, with different structures appearing according to the stage of cell differentiation and according to the age or health of the individual. The advent of technologies that have allowed carbohydrate structures and carbohydrate-protein binding events to be more easily interrogated has resulted in these types of interactions taking their place in modern immunology. We now know that glycans and their ligands (or lectins) are involved in numerous immunological pathways of both the innate and adaptive systems. However, it is clear that our understanding is still in its infancy, as more and more examples where carbohydrate structures contribute to aspects of the immune response are being recognised. The goal of this research topic is to explore the variety of roles undertaken by glycans and lectins in all aspects of the immune response. The particular focus is how the interactions of glycans with their ligands contribute to the mechanism of immune responses
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  • 186
    ISBN: 9782889194056
    Language: English
    Pages: 1 Online-Ressource (172 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases
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  • 187
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    ISBN: 9782889196203
    Language: English
    Pages: 1 Online-Ressource (88 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Among the many molecules present in our environment, some have the property to induce allergic sensitization and IgE-mediated reactions. The analysis of known major animal allergens has shown that most belong to single protein families: lipocalins and serum albumins for inhalant allergens, EF-hand proteins, tropomyosins and caseins for the digestive allergens. The finding that allergens are often clustered in large families may be related to the fact that common structural, biochemical or functional features contribute to their allergenicity, in addition to external adjuvant factors. Currently, there is no curative treatment for animal allergy available. In order to lower allergic reactions to respiratory allergens in daily life and to food allergens upon accidental exposure, it is important to desensitize concerned patients. Tolerance induction by allergen-specific immunotherapy is in the current focus of an ambitious research. This Research Topic aims to provide a comprehensive view of the basic and recent insights on the allergenicity of animal allergens in view of their structural and functional aspects as well as allergen-specific immunotherapy
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  • 188
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    ISBN: 9782889195534
    Language: English
    Pages: 1 Online-Ressource (87 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Though traditionally designed for entertainment, video games are being used more and more by psychologists to understand topics such as skill acquisition, cognitive capacity and plasticity, aging, individual differences, and development. The appeal of using video games over simpler laboratory paradigms partly comes from their ability to present rich and complex cognitive challenges more representative of the demands of the complex everyday tasks we perform outside of the laboratory. However, this complexity also presents a host of methodological and analytic challenges. This Research Topic brings together research using games to explore cognitive processes, with a special focus on the challenges of this approach. Challenges are in terms of design, implementation, or data analysis
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  • 189
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    ISBN: 9782889196548
    Language: English
    Pages: 1 Online-Ressource (105 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling
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  • 190
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    ISBN: 9782889194926
    Language: English
    Pages: 1 Online-Ressource (101 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Microglial cells play a v ...
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  • 191
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    ISBN: 9782889196067
    Language: English
    Pages: 1 Online-Ressource (135 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Highly emotional events tend to be well remembered. The adaptive value in this is clear – those events that have a bearing on survival should be stored for future use as long-term memories whereas memories of inconsequential events would not as likely contribute to future survival. Enduring changes in the structure and function of synapses, neural circuitry, and ultimately behavior, can be modulated by highly aversive or rewarding experiences. In the last decade, the convergence of cellular, molecular, and systems neuroscience has produced new insights into the biological mechanisms that determine whether a memory will be stored for the long-term or lost forever. This Research Topic brings together leading experts, who work at multiple levels of analysis, to reveal recent discoveries and concepts regarding the synaptic mechanisms of consolidation and extinction of emotionally arousing memories
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  • 192
    ISBN: 9782889195602
    Language: English
    Pages: 1 Online-Ressource (202 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Current theories of visual change detection emphasize the importance of conscious attention to detect unexpected changes in the visual environment. However, an increasing body of studies shows that the human brain is capable of detecting even small visual changes, especially if such changes violate non-conscious probabilistic expectations based on repeating experiences. In other words, our brain automatically represents statistical regularities of our visual environmental. Since the discovery of the auditory mismatch negativity (MMN) event-related potential (ERP) component, the majority of research in the field has focused on auditory deviance detection. Such automatic change detection mechanisms operate in the visual modality too, as indicated by the visual mismatch negativity (vMMN) brain potential to rare changes. VMMN is typically elicited by stimuli with infrequent (deviant) features embedded in a stream of frequent (standard) stimuli, outside the focus of attention. In this research topic we aim to present vMMN as a prediction error signal. Predictive coding theories account for phenomena such as mismatch negativity and repetition suppression, and place them in a broader context of a general theory of cortical responses. A wide range of vMMN studies has been presented in this Research Topic. Twelve articles address roughly four general sub-themes including attention, language, face processing, and psychiatric disorders. Additionally, four articles focused on particular subjects such as the oblique effect, object formation, and development and time-frequency analysis of vMMN. Furthermore, a review paper presented vMMN in a hierarchical predictive coding framework. Each paper in this Research Topic is a valuable contribution to the field of automatic visual change detection and deepens our understanding of the short term plasticity underlying predictive processes of visual perceptual learning
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  • 193
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    ISBN: 9782889196128
    Language: English
    Pages: 1 Online-Ressource (117 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cereal crops such as maiz ...
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  • 194
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    ISBN: 9782889192953
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Understanding the role of sleep and the mechanisms at play in ageing are among the most exciting challenges in neuroscience. Although our understanding of the mechanisms governing sleep stages and their role in cognitive processes including memory functions is gradually increasing. most of the currently available data have been gathered in young adults. Still, substantial physiological changes in sleep are observed with increasing age, that may markedly impacts on daily functioning. This is why this Research Topic focuses on our current understanding of the impact of age-related changes in sleep architecture on various domains of cognition. The three editors Julie Carrier (Montréal, Canada), Philippe Peigneux (Brussels, Belgium) and Géraldine Rauchs (Caen, France) are specialized in various fields of sleep research. Here, they bring together an outstanding group of neuroscientist and clinical investigators engaged in the study of sleep, encompassing state-of-the-art studies of sleep disorders such as sleep apnoea or REM sleep behaviour disorder, studies assessing new treatments to improve sleep quality, together with experts in various domains of cognition such as vigilance, memory and dreams, in a perspective aimed at offering the interested reader a comprehensive view of the impact of age-related changes in sleep architecture on cognition
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  • 195
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    ISBN: 9782889196241
    Language: English
    Pages: 1 Online-Ressource (238 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The sense of agency is de ...
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  • 196
    ISBN: 9782889195800
    Language: English
    Pages: 1 Online-Ressource (205 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This e-book brings together scholars in both the neurosciences and organizational sciences who have adopted various approaches to study the cognitive mechanisms mediating the social behavior that we see within organizations. Such an approach has been termed by ourselves, and others, as ‘organisational cognitive neuroscience’. In recent years there has been a veritable increase in studies that have explored the cognitive mechanisms driving such behaviors, and much progress has been made in understanding the neural underpinnings of processes such as financial exchange, risk awareness and even leadership. However, while these studies are informative and add to our understanding of human cognition they fall short of providing evidence-based recommendations for practice. Specifically, we address the broader issue of how the neuroscientific study of such core social behaviors can be used to improve the very way that we work. To address these gaps in our understanding the chapters in this book serve as a platform that allows scholars in both the neurosciences and the organizational sciences to highlight the work that spans across these two fields. The consolidation of these two fields also serves to highlight the utility of a singular organizational cognitive neuroscience. This is a fundamentally important outcome of the book as the application of neuroscience to address economically relevant behaviors has seen a variety of fields evolve in their own right, such as neuromarketing, neuroeconomics and so forth. The use of neuro-scientific technologies,in particular fMRI, has indeed led to a bewildering (and somewhat suffocating) proliferation of new approaches, however, the speed of such developments demands that we must proceed carefully with such ventures or risk some fundamental mistakes. The book that you now hold will consolidates these new neuroscience based approaches and in doing so highlight the importance of this approach in helping us to understand human social behavior in general. Taken together the chapters provide a framework for scholars within the neurosciences who wish to explore the further the opportunities that the study of organisational behavior may provide
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  • 197
    ISBN: 9782889196838
    Language: English
    Pages: 1 Online-Ressource (107 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential
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  • 198
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    ISBN: 9782889194414
    Language: English
    Pages: 1 Online-Ressource (115 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Reversible ubiquitylation plays an important regulatory role in almost all aspects of cellular and organismal processes in plants. Its pervasive regulatory role in plant biology is primarily due to the involvement of a large set of ubiquitin system constituents (encoded by approximately 6% Arabidopsis genome), the huge number of important cellular proteins targeted as substrates, and various drastic effects on the modified proteins. The major components of the ubiquitin system include a large set of enzymes and proteins involved in ubiquitin conjugation (E1s, E2s, and E3s) and deconjugation (deubiquitinases of different classes) and post ubiquitin conjugation components such as ubiquitin receptors, endocytic machineries, and 26S proteasome. The established substrates include transcriptional activators and repressors, signaling components, key metabolic enzymes, and critical mechanistic components of major cellular processes and regulatory mechanisms. Post-translational modification of proteins by reversible ubiquitylation could drastically affects the modified proteins by proteolytic processing and turnover, altering catalytic activity, subcellular targeting, and protein-protein interaction. Continued efforts are being carried out to identify novel substrates critical for various cellular and organismal processes, to determine effects of reversible ubiquitylation on the modified substrates, to determine signaling determinants triggering reversible ubiquitylation of specific substrates, to illustrate individual components of the ubiquitin system for their in vivo functions and involved mechanistic roles, and to determine mechanistic roles of modification acting on critical components of major cellular processes and regulatory mechanisms. The aim of this special topic is to serve as a platform to report most recent advances on those above listed current research endeavors. We welcome article types including original research, review, mini review, method, and perspective/opinion/hypothesis
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  • 199
    ISBN: 9782889195190
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The advent of educational neuroscience, a transdisciplinary exercise emerging from cognitive neuroscience and educational psychology, is the examination of physiological processes that undermine, support, and enhance the capacities to learn and create. The physiological underpinnings of learning and creativity each impact human ability and performance and mediate the processes of becoming educated, expert, and valued. Evidence of learning provides support to an ongoing canon, process, system, field or domain, while evidence of creativity results in an elaboration or departure from an ongoing canon, process, system, field, or domain. Educational neuroscience extends a challenge to scholars from multiple contexts to engage in the characterization and exploration of human ability and performance in these realms. The role of context, both environmental and interoceptive, is an integral part of efforts in educational neuroscience and in theories of constructivist learning to contribute ecologically valid insight to the pragmatic processes of learning and creativity. Examination at this level of specificity is vital to our ability to educate and support human potential in the 21st century. This Research Topic examines the neural basis of cognitive states and processes that influence knowledge and skill acquisition tied to the demonstration of human ability and performance across individual differences and in multiple contexts including STEM learning and the arts
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  • 200
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    ISBN: 9782889194988
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties
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