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  • 2015-2019  (342)
  • 1995-1999
  • 2015  (342)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (342)
  • 1
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195978
    Language: English
    Pages: 1 Online-Ressource (91 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Complex systems are to be seen as typically having multiple levels of organization. For instance, in the behavioural and cognitive sciences, there has been a long lasting trend, promoted by the seminal work of David Marr, putting focus on three distinct levels of analysis: the computational level, accounting for the What and Why issues, the algorithmic and the implementational levels specifying the How problem. However, the tremendous developments in neuroscience knowledge about processes at different scales of organization together with the complexity of today cognitive theories suggest that there will hardly be only three levels of explanation. Instead, there will be many different degrees of commitments corresponding to the different granularities - from high-level (behavioural) models to low-level (neural and molecular) models of the cognitive research program. For instance, Bayesian approaches, that are usually advocated for formalizing Marr's computational level and rational behaviour, have even been adopted to model synaptic plasticity and axon guidance by molecular gradients. As a result, we can consider the behavioural scientist as dealing with models at a multiplicity of levels. The purpose of this Research Topic in Frontiers in Theoretical and Philosophical Psychology is to promote an approach to the role of the levels and explanation and models which is of interest for cognitive scientists, neuroscientists, psychologists, behavioural scientists, and philosophers of science
    Note: English
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  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196920
    Language: English
    Pages: 1 Online-Ressource (171 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and dendritic wiring. This wiring enables both near and distant cells to coordinate their responses and generate a rich variety of cognitions and behaviours. When the wiring is damaged through disease or trauma it may reorganize but this may lead to characteristic pathological behaviours. While there have been significant advances in mapping cortical connectivity, the organizing principles and function of this connectivity are not well understood. On the one hand, there appears to be general design constraints governing cortical wiring, as first recognised by Rámon y Cajal's in his laws of conduction, material, and volume conservation. Yet on the other hand, particular patterns of cortical wiring exist to serve specific functions. There is a wide gap in understanding how the response and connectivity properties of a single neuron contribute to emergent network functions such as in detecting perceptually relevant features. Unravelling this intimate causal relationship represents one of the major challenges in neuroscience. This Research Topic will examine progress in understanding cortical wiring principles. This Research Topic aims to draw together recent advances in methods and understanding as well as recent challenges to existing ideas about how cerebral cortex is wired. This is particularly timely because new automated techniques may soon yield huge datasets in need of explanation. Recent studies have, for instance, empirically evaluated Rámon y Cajal's conservation laws for cerebral cortex, while others have shown some unexpected connectivity features that may refine the traditional view of how corticocortical connections are organised with regard to functional representations of auditory, somatosensory and visual cortices. Understanding these data will help improve the fidelity of neural models of cerebral cortical function and take into account the diversity of connections at both micro- and mesoscopic scales not seen at such a depth before
    Note: English
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  • 3
    ISBN: 9782889194483
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Viruses infect numerous microorganisms including, predominantly, Bacteria (bacteriophages or phages) but also Archaea, Protists, and Fungi. They are the most abundant and ubiquitous biological entities on Earth and are important drivers of ecosystem functioning. Little is known, however, about the vast majority of these viruses of microorganisms, or VoMs. Modern techniques such as metagenomics have enabled the discovery and description of more presumptive VoMs than ever before, but also have exposed gaps in our understanding of VoM ecology. Exploring the ecology of these viruses – which is how they interact with host organisms, the abiotic environment, larger organisms, and even other viruses across a variety of environments and conditions – is the next frontier. Integration of a growing molecular understanding of VoMs with ecological studies will expand our knowledge of ecosystem dynamics. Ecology can be studied at multiple levels including individual organisms, populations, communities, whole ecosystems, and the entire biosphere. Ecology additionally can consider normal, equilibrium conditions or instead perturbations. Perturbations are of particular interest because measuring the effect of disturbances on VoM-associated communities provides important windows into how VoMs contribute to ecosystem dynamics. These disturbances in turn can be studied through in vitro, in vivo, and in situ experimentation, measuring responses by VoM-associated communities to changes in nutrient availability, stress, physical disruption, seasonality, etc., and could apply to studies at all ecological levels. These are considered here across diverse systems and environments
    Note: English
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  • 4
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194315
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Organisms are equipped with value systems that signal the salience of environmental cues to their nervous system, causing a change in the nervous system that results in modification of their behavior. These systems are necessary for an organism to adapt its behavior when an important environmental event occurs. A value system constitutes a basic assumption of what is good and bad for an agent. These value systems have been effectively used in robotic systems to shape behavior. For example, many robots have used models of the dopaminergic system to reinforce behavior that leads to rewards. Other modulatory systems that shape behavior are acetylcholine’s effect on attention, norepinephrine’s effect on vigilance, and serotonin’s effect on impulsiveness, mood, and risk. Moreover, hormonal systems such as oxytocin and its effect on trust constitute as a value system. This book presents current research involving neurobiologically inspired robots whose behavior is: 1) Shaped by value and reward learning, 2) adapted through interaction with the environment, and 3) shaped by extracting value from the environment
    Note: English
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  • 5
    ISBN: 9782889195435
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common form of lung cancer, accounting for approximately 87% of cases. Systemic chemotherapies have been used to treat metastatic NSCLC for decades, but the improvements of outcomes have reached a plateau. Recent advances in understanding signalling pathways for malignant cells, their interconections,the importance of various receptors and biomarkers and the interplay between various oncogenes have led to the development of targeted treatments that are improving both efficacy and safety of the treatments. Knowledge about the advantages of treatments with the targeted agents in metastatic NSCLC is growing rapidly. Combining various targeted agents or sequencing them properly will be important in the era of personalised medicine and overcoming development of the resistence to various targeted agents will be challenging. The importance of a team work,from the diagnosis through various treatments, to supportive care, from the interventional radiologists, pneumologists or surgeons, who have to obtain a satisfactory tumor tissue specimen, to pathologists, radiation and medical oncologists, to supportive care specialists, will be described in our publications. We will cover completely present and future approaches to personalised medicine in this rapidly evolving field of metastatic NSCLC
    Note: English
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  • 6
    ISBN: 9782889195299
    Language: English
    Pages: 1 Online-Ressource (413 p.)
    Series Statement: Frontiers Research Topics
    Abstract: An important amount of research effort in psychology and neuroscience over the past decades has focused on the problem of social cognition. This problem is understood as how we figure out other minds, relying only on indirect manifestations of other people's intentional states, which are assumed to be hidden, private and internal. Research on this question has mostly investigated how individual cognitive mechanisms achieve this task. A shift in the internalist assumptions regarding intentional states has expanded the research focus with hypotheses that explore the role of interactive phenomena and interpersonal histories and their implications for understanding individual cognitive processes. This interactive expansion of the conceptual and methodological toolkit for investigating social cognition, we now propose, can be followed by an expansion into wider and deeply-related research questions, beyond (but including) that of social cognition narrowly construed. Our social lives are populated by different kinds of cognitive and affective phenomena that are related to but not exhausted by the question of how we figure out other minds. These phenomena include acting and perceiving together, verbal and non-verbal engagement, experiences of (dis-)connection, management of relations in a group, joint meaning-making, intimacy, trust, conflict, negotiation, asymmetric relations, material mediation of social interaction, collective action, contextual engagement with socio-cultural norms, structures and roles, etc. These phenomena are often characterized by a strong participation by the cognitive agent in contrast with the spectatorial stance typical of social cognition research. We use the broader notion of embodied intersubjectivity to refer to this wider set of phenomena. This Research Topic aims to investigate relations between these different issues, to help lay strong foundations for a science of intersubjectivity – the social mind writ large. To contribute to this goal, we encouraged contributions in psychology, neuroscience, psychopathology, philosophy, and cognitive science that address this wider scope of intersubjectivity by extending the range of explanatory factors from purely individual to interactive, from observational to participatory
    Note: English
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  • 7
    ISBN: 9782889195169
    Language: English
    Pages: 1 Online-Ressource (136 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Prosocial behaviors such ...
    Note: English
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  • 8
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196241
    Language: English
    Pages: 1 Online-Ressource (238 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The sense of agency is de ...
    Note: English
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  • 9
    ISBN: 9782889193165
    Language: English
    Pages: 1 Online-Ressource (91 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cigarette smoke exposure is the key initiator of chronic inflammation, alveolar destruction, and the loss of alveolar blood vessels that lead to the development of chronic obstructive pulmonary disease (COPD) which is comprised of emphysema and chronic bronchitis. Exposure to secondhand smoke (SHS) is the major risk factor for non-smokers to develop emphysema. While the first-hand smoke is directly inhaled by smokers, passive smoking occurs when non-smokers are involuntary exposed to environmental tobacco smoke also known as second hand smoke (SHS). SHS is a mixture of 2 forms of smoke that come from burning tobacco: side stream smoke (smoke that comes from the end of a lit cigarette, pipe, or cigar) and mainstream smoke (smoke that is exhaled by a smoker). These two types of smoke have basically the same composition, however in SHS many toxic components are more concentrated than in first-hand smoke, therefore more hazardous for people’s health. Several pathological events have been implicated in the development of SHS-induced COPD, but many aspects of this pathology remain poorly understood halting the development of new advanced treatments for this detrimental disease. In this respect we have welcomed leading investigators in the field to share their research findings and provide their thoughts regarding the mechanisms of the SHS exposure-induced immune responses and inflammatory mechanisms of lung destruction in SHS-induced COPD and related comorbidities
    Note: English
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  • 10
    ISBN: 9782889194810
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming
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  • 11
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889195510
    Language: English
    Pages: 1 Online-Ressource (91 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Ergot alkaloids produced by fungi have a basic chemical structure but different chemical moieties at substituent sites result in various forms of alkaloids that are distinguishable from one another. Since the ergoline ring structure found in ergot alkaloids is similar to that of biogenic amines (neurotransmitters), a variety of physiological effects can result after ingestion. Research involving ergot alkaloids is an increasing important global issue as more governments pass laws that limit permissible levels of ergot alkaloids in both foodstuffs and feedstuffs. Regardless of whether these compounds are found directly in foodstuffs or in feed/plants given to forage animals (i.e., cattle, horses, sheep, and goats), introduction of these compounds can complicate the food supply. In addition, toxicosis resulting from alkaloids can be a costly hindrance, with mounting annual production losses associated with forage-animal production systems that impact other agricultural and food based industries. Recent advances for the analysis of these compounds in different matrices as well as the understanding the role these compounds play in distinct biological pathways have begun to help address the issue. This Research Topic has developed a novel platform where different groups share recent data in their investigations with ergot alkaloids. The presented collection of articles emphasizes the complexity of this issue and the multiple approaches necessary to resolve the global ergot alkaloid challenges
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  • 12
    ISBN: 9782889195114
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Dengue is the most import ...
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  • 13
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194476
    Language: English
    Pages: 1 Online-Ressource (94 p.)
    Series Statement: Frontiers Research Topics
    Abstract: When faced with a difficult task, people often look at the sky or close their eyes. This behavior is functional: the reduction of distractions in the environment can improve performance on cognitive tasks, including memory retrieval. Reduction of visual distractions can be operationalized through eye-closure, gaze aversion, or by comparing exposure to simple and complex visual displays, respectively. Reduction of auditory distractions is typically examined by comparing performance under quiet and noisy conditions. Theoretical reasoning regarding this phenomenon draws on various psychological principles, including embodied cognition, cognitive load, and modality-specific interference. Practical applications of the research topic are diverse. For example, the findings could be used to improve performance in forensic settings (e.g., eyewitness testimony), educational settings (e.g., exam performance), occupational settings (e.g., employee productivity), or medical settings (e.g., medical history reporting). This Research Topic welcomes articles from all areas of psychology relating to the reduction of distractions to improve task performance. Articles can address (but are not limited to) new empirical findings, comprehensive reviews, theoretical frameworks, opinion pieces, or discussions of practical applications
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  • 14
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196517
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Series Statement: Frontiers Research Topics
    Abstract: G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market. However, endogenous GPCRs are most often difficult to study because of a lack of tools to target them specifically and single out their response to physiological or drug-elicited stimulations. Hence, studies mostly focused on recombinant receptors expressed in a variety of cellular models that do not always closely reflect the receptor natural environment and often deal with levels of expression exceeding by far physiological ranges. Recent technological developments combining for example genetically modified animals and advanced imaging approaches have improved our ability to visualize endogenous GPCRs. To date, trailing receptor activation, subsequent intracellular redistribution, changes in signaling cascade up to integrated response to a drug-elicited stimulation is at hand though the impact of a physiological challenge on receptor dynamics remains a major issue. Data however suggest that the receptor may embrace a different fate depending on the type of stimulation in particular if sustained or repeated. This suggests that current drugs may only partially mimic the genuine response of the receptor and may explain, at least in part, their secondary effects. Commonalities and specificities between physiological and drug-induced activation can thus represent valuable guidelines for the design of future drugs
    Note: English
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  • 15
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194032
    Language: English
    Pages: 1 Online-Ressource (179 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The formation of the proper pattern of neuronal circuits during development is critical for the normal function of the vertebrate brain and for the survival of the organism. Circuit tracing studies spanning the past 100 years have revealed the beauty and exquisite intricacy of this pattern, which represents the most complex biological system known. In humans, aberrant circuit formation is a likely underlying cause of a wide variety of birth defects and neurological disorders, including autism, intellectual disability, and schizophrenia. Furthermore, future therapeutic approaches to restoring the function of damaged neural circuits will require a better understanding of the developmental constraints under which those circuits were originally assembled. For these reasons, elucidating the molecular mechanisms of neural circuit formation is a major goal of neurobiology today
    Note: English
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  • 16
    ISBN: 9782889195831
    Language: English
    Pages: 1 Online-Ressource (201 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Researchers working in many fields of psychology and neuroscience are interested in the temporal structure of experience, as well as the experience of time, at scales of a few milliseconds up to a few seconds as well as days, months, years, and beyond. This Research Topic supposes that broadly speaking, the field of "time psychology" can be organized by distinguishing between "perceptual" and "conceptual" time-scales. Dealing with conceptual time: "mental time travel," also called mental simulation, self-projection, episodic-semantic memory, prospection/foresight, allows humans (and perhaps other animals) to imagine and plan events and experiences in their personal futures, based in large part on memories of their personal pasts, as well as general knowledge. Moreover, contents of human language and thought are fundamentally organized by a temporal dimension, enmeshed with it so thoroughly that it is usually expressible only through spatial metaphors. But what might such notions have to do with experienced durations of events lasting milliseconds up to a few seconds, during the so-called "present moment" of perception-action cycle time? This Research Topic is organized around the general premise that, by considering how mental time travel might "scale down" to time perception (and vice-versa, no less), progress and integrative synthesis within- and across- scientific domains might be facilitated. Bipolar configurations of future- and past-orientations of the self may be repeated in parallel across conceptual and perceptual time-scales, subsumed by a general "Janus-like" feedforward-feedback system for goal-pursuit. As an example, it is notable that the duality of "prospection" and semantic-episodic memory operating at conceptual time-scales has an analogue in perception-action cycle time, namely the interplay of anticipatory attention and working memory. Authors from all areas of psychology and neuroscience are encouraged to submit articles of any format accepted by the journal (Original Research, Methods, Hypothesis & Theory, Reviews, etc.), which might speak to questions about time and temporal phenomena at long and/or short time-scales
    Note: English
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  • 17
    ISBN: 9782889196760
    Language: English
    Pages: 1 Online-Ressource (194 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease
    Note: English
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  • 18
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889197279
    Language: English
    Pages: 1 Online-Ressource (74 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In his 1962 book "The Str ...
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  • 19
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196968
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Our brain is endowed with ...
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  • 20
    ISBN: 9782889196647
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: An exciting new line of research that investigates the impact of one’s own hands on visual processing has flourished in the past several years. Specifically, several studies have demonstrated that objects near the hands receive prioritized attention, enhanced perceptual sensitivity, altered figure-ground assignment, prolonged and detail-oriented processing, and improved visual working memory. Taken together, these results demonstrate that the visual system reveals a new pattern of processing when one's hands are in proximity of viewed objects. Therefore, the vast majority of studies on visual processing, in which one's hands are kept away from the stimuli, may constitute but one side of a more complex story of the inner workings of the visual system. With several consistent behavioral demonstrations of hand-altered vision now in the literature, the present challenge facing this growing field, and the aim of this Research Topic, is four-pronged: 1) Isolate and elucidate the underlying cognitive and neural mechanisms of hand-altered vision; 2) Map the parameters and conditions of hand-nearness that permit/prevent the onset or maintenance of hand-altered vision; 3) Determine the consequences of hand-altered vision for higher-level cognition and assess its applied potential (e.g., as a neuropsychological intervention); and, 4) Present a cohesive and predictive theoretical account of hand-altered vision. We welcome submissions that fit into any one (or a combination) of the above domains. For behavioral research, we particularly encourage submissions that are relevant to the advancement of our understanding of the neural mechanisms of hand-altered vision (e.g., demonstrations that might corroborate or disconfirm proposed neural systems)
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  • 21
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196067
    Language: English
    Pages: 1 Online-Ressource (135 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Highly emotional events tend to be well remembered. The adaptive value in this is clear – those events that have a bearing on survival should be stored for future use as long-term memories whereas memories of inconsequential events would not as likely contribute to future survival. Enduring changes in the structure and function of synapses, neural circuitry, and ultimately behavior, can be modulated by highly aversive or rewarding experiences. In the last decade, the convergence of cellular, molecular, and systems neuroscience has produced new insights into the biological mechanisms that determine whether a memory will be stored for the long-term or lost forever. This Research Topic brings together leading experts, who work at multiple levels of analysis, to reveal recent discoveries and concepts regarding the synaptic mechanisms of consolidation and extinction of emotionally arousing memories
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  • 22
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196463
    Language: English
    Pages: 1 Online-Ressource (92 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons
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  • 23
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889192953
    Language: English
    Pages: 1 Online-Ressource (78 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Understanding the role of sleep and the mechanisms at play in ageing are among the most exciting challenges in neuroscience. Although our understanding of the mechanisms governing sleep stages and their role in cognitive processes including memory functions is gradually increasing. most of the currently available data have been gathered in young adults. Still, substantial physiological changes in sleep are observed with increasing age, that may markedly impacts on daily functioning. This is why this Research Topic focuses on our current understanding of the impact of age-related changes in sleep architecture on various domains of cognition. The three editors Julie Carrier (Montréal, Canada), Philippe Peigneux (Brussels, Belgium) and Géraldine Rauchs (Caen, France) are specialized in various fields of sleep research. Here, they bring together an outstanding group of neuroscientist and clinical investigators engaged in the study of sleep, encompassing state-of-the-art studies of sleep disorders such as sleep apnoea or REM sleep behaviour disorder, studies assessing new treatments to improve sleep quality, together with experts in various domains of cognition such as vigilance, memory and dreams, in a perspective aimed at offering the interested reader a comprehensive view of the impact of age-related changes in sleep architecture on cognition
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  • 24
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196173
    Language: English
    Pages: 1 Online-Ressource (99 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This collection represents certain discoveries that were made in evolutionary and genomic microbiology during the recent ten years. We attempted to shed light on topical issues of microbial evolution and microbiome biology. In our eyes, these articles are of an excellent quality and may be helpful both for casual readers and for specialists in the field
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  • 25
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196746
    Language: English
    Pages: 1 Online-Ressource (201 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field
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  • 26
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    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889196906
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function
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  • 27
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    ISBN: 9782889194858
    Language: English
    Pages: 1 Online-Ressource (135 p.)
    Series Statement: Frontiers Research Topics
    Abstract: So-called altered states ...
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  • 28
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    ISBN: 9782889193820
    Language: English
    Pages: 1 Online-Ressource (223 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder
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  • 29
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    ISBN: 9782889195619
    Language: English
    Pages: 1 Online-Ressource (181 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Deciphering anatomical and functional maps in the nervous system is a main challenge for both clinical and basic neuroscience. Modern approaches to mark and manipulate neurons are bringing us closer than ever to better understand nervous system wiring diagrams. Here we present both original research and review material on current work in this area. Together, this eBook aims to provide a comprehensive snapshot of some of the tools and technologies currently available to investigate brain wiring and function, as well as discuss ongoing challenges the field will be confronted with in the future
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  • 30
    ISBN: 9782889194797
    Language: English
    Pages: 1 Online-Ressource (246 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications
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  • 31
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    ISBN: 9782889196975
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas
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  • 32
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    ISBN: 9782889193295
    Language: English
    Pages: 1 Online-Ressource (156 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The advent of behavior-independent measures of cognition and major progress in experimental designs have led to substantial advances in the investigation of infant language learning mechanisms. Research in the last two decades has shown that infants are very efficient users of perceptual and statistical cues in order to extract linguistic units and regular patterns from the speech input. This has lent support for learning-based accounts of language acquisition that challenge traditional nativist views. Still, there are many open questions with respect to when and how specific patterns can be learned and the relevance of different types of input cues. For example, first steps have been made to identify the neural mechanisms supporting on-line extraction of words and statistical regularities from speech. Here, the temporal cortex seems to be a major player. How this region works in concert with other brain areas in order to detect and store new linguistic units is a question of broad interest. In this Research Topic of Frontiers in Language Sciences, we bring together experimental and review papers across linguistic domains, ranging from phonology to syntax that address on-line language learning in infancy. Specifically, we focused on papers that explore one of the following or related questions: How and when do infants start to segment linguistic units from the speech input and discover the regularities according to which they are related to each other? What is the role of different linguistic cues during these acquisition stages and how do different kinds of information interact? How are these processes reflected in children’s behavior, how are they represented in the brain and how do they unfold in time? What are the characteristics of the acquired representations as they are established, consolidated and stored in long-term memory? By bringing together behavioral and neurophysiological evidence on language learning mechanisms, we aim to contribute to a more complete picture of the expeditious and highly efficient early stages of language acquisition and their neural implementation
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  • 33
    ISBN: 9782889194148
    Language: English
    Pages: 1 Online-Ressource (274 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Our everyday life is characterized by a multitude of emotionally relevant cues that we perceive and communicate via various sensory channels. This does not only encompass the obvious cases of auditory and visual modalities, but also olfactory, gustatory, and even tactile stimuli. Any kind of emotional situation in a natural setting is usually a multimodal experience: A friend welcomes us with warm words, a smile, and a happy voice; the sight of our favourite food is accompanied by a seductive smell and a delicious taste; the thrill of watching an exciting movie scene is intensified by a gripping soundtrack. In these situations, the signals from various senses do not stand on their own; they interact and create a unified emotional experience. Recent neuroscientific research has begun to accommodate this inherent multimodality of emotions in natural situations by studying the interaction of affectively relevant information from more than one sensory channel. Fascinating new aspects emerge concerning the neurobiology of emotion processing, and there is evidence that integrating emotional cues from various sources invokes brain processes that go beyond the well-known patterns observed during unimodal stimulation. The aim of this volume is to present novel and interesting studies dealing with the multimodality of emotions and their neural processing. This includes findings from novel paradigms beyond the classical stimulus-response pattern, fascinating new insights into the interaction of the chemical senses, new analysis methods, comprehensive reviews of selected topics, multimodality in social interactions, and clinical perspectives. Taken together, the studies of this volume thus help us to better understand the interplay of various senses in our daily emotional experiences
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  • 34
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    ISBN: 9782889196043
    Language: English
    Pages: 1 Online-Ressource (166 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This topic covers emerging knowledge about the properties and functions of the outer membranes of chloroplasts and mitochondria. These outer membranes house various processes necessary for efficient communication and thus integration of the organelles with and into their surroundings in the cytoplasm. Such processes include, but are not limited to, protein import, organelle division, organelle movement, metabolism, and metabolite/ion transport. Recent molecular genetic, biochemical and cell biological studies have revealed functions of various outer membrane proteins. These findings have helped address and generate diverse biological and evolutionary questions at molecular, cellular and whole organism levels. The topic should encourage contributions of scientists from various disciplines and thus would provide the field with opportunities to "think outside the box" and to develop potential collaborations. The topic is also aimed to stimulate interests of general audience in the outer membranes of chloroplasts and mitochondria
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  • 35
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    ISBN: 9782889196128
    Language: English
    Pages: 1 Online-Ressource (117 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cereal crops such as maiz ...
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  • 36
    ISBN: 9782889196135
    Language: English
    Pages: 1 Online-Ressource (314 p.)
    Series Statement: Frontiers Research Topics
    Abstract: What can we learn from sp ...
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  • 37
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    ISBN: 9782889193974
    Language: English
    Pages: 1 Online-Ressource (129 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as neurodegenerative diseases, cystic fibrosis, diabetes and cancer. It has recently emerged that virus infections can trigger the UPR but the relationship between virus infections and host UPR is intriguing. On one hand, UPR is harmful to the virus and virus has developed means to subvert the UPR. On the other hand, virus exploits the host UPR to assist in its own infection, gene expression, establishment of persistence, reactivation from latency and to evade the immune response. When this delicate balance of virus-host UPR interaction is broken down, it may cause diseases. This is particularly challenging for viruses that establish a chronic infection to maintain this balance. Each virus interacts with the host UPR in a different way to suit their life style and how the virus interacts with the host UPR can define the characteristic of a particular virus infection. Understanding how a particular virus interacts with the host UPR may pave the way to the design of a new class of anti-viral that targets this particular pathway to skew the response towards anti-virus. This knowledge can also be translated into the clinics to help re-design oncolytic virotherapy and gene therapy. In this research topic we aimed to compile a collection of focused review articles, original research articles, commentary, opinion, hypothesis and methods to highlight the current advances in this burgeoning area of research, in an attempt to provide an in-depth understanding of how viruses interact with the host UPR, which may be beneficial to the future combat of viral and human diseases
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  • 38
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    ISBN: 9782889194742
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Transfer cells are anatom ...
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  • 39
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    ISBN: 9782889195183
    Language: English
    Pages: 1 Online-Ressource (89 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This research topic stems from the "Interdisciplinary Approaches to Multilingualism" conference, which was hosted by the Language Research Centre at the University of Calgary. It was the first conference of its kind, which brought together the work of researchers, educators, and policy makers in the areas of first and second language acquisition from psycholinguistic and pedagogical perspectives. The goal was to provide an opportunity for participants to engage with the implications of multilingualism from a range of perspectives, including the effects of being bilingual from infancy to adulthood, the process and benefits of learning multiple languages, and the impact of multilingualism on society
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  • 40
    ISBN: 9782889194650
    Language: English
    Pages: 1 Online-Ressource (114 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The study of plant cell p ...
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  • 41
    ISBN: 9782889195046
    Language: English
    Pages: 1 Online-Ressource (77 p.)
    Series Statement: Frontiers Research Topics
    Abstract: ATP is normally regarded ...
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  • 42
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    ISBN: 9782889194544
    Language: English
    Pages: 1 Online-Ressource (182 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems
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  • 43
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    ISBN: 9782889196425
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In 2011, the National Ins ...
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  • 44
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    ISBN: 9782889195077
    Language: English
    Pages: 1 Online-Ressource (189 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress
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  • 45
    ISBN: 9782889196333
    Language: English
    Pages: 1 Online-Ressource (98 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Across species, humans have an unsurpassed capacity for creative thought and innovation. Human creativity is at the roots of extraordinary achievements in the arts and sciences, and enables individuals and their groups to adapt flexibly to changing circumstances, to manage complex social relations, and to survive and prosper through social, technological, and medical innovations. The ability to generate novel and potentially useful ideas and problem solutions (viz., creativity) is a key driver of human evolution, and among the most valued and sought after competencies in contemporary societies that struggle with complex problems and compete for technological and economic supremacy. Because creativity provides fitness functionality in both ancestral and contemporary societies, it stands to reason that (i) the human brain evolved to sustain and promote creative thinking and we should be able to identify (ii) the brain circuitries, genetic drivers, and neurohormonal modulators of the human capacity for creative problem solving and original ideation; and (iii) the core cognitive and emotional processes underlying creative thought. In this Research Topic, we bring together a collection of papers to provide an encyclopedic, open access snapshot of the current state of the art on the neural, cognitive, and emotional correlates of creativity
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  • 46
    ISBN: 9782889194629
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Habituation describes the ...
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  • 47
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    ISBN: 9782889194339
    Language: English
    Pages: 1 Online-Ressource (100 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend support to the idea that Aß is not causative but can be considered as an “innocent bystander” in AD. Although preclinical research generated impressive lines of evidence about the several intracellular mechanism(s) whose impairment leads to the onset and progression of AD, clinical research aimed at the development of new drugs capable of preventing or delaying the onset of neuronal damage in AD patients has produced limited results. The drugs currently available for the treatment of AD are acetylcholinesterase inhibitors (AChEI) and the NMDA glutamate receptor antagonist memantine. The AChEI increase acetylcholine levels in the synaptic cleft, which are reduced because of the progressive damage of cholinergic neurons in cognitive brain areas (e.g. amygdala, hippocampus, and frontal cortex), whereas memantine is used to prevent/reduce calcium-dependent excitotoxic neuronal cell death. Both classes of drugs have been shown to improve symptoms related to cognitive decline, but their effects are confined largely to patients with mild to moderate AD, in particular during the first year or so of treatment. An alternative to this symptomatic treatments involves the use of drugs that intervene in the pathogenesis of the disease. Recently, monoclonal antibodies against Aß were proposed as novel agents capable to remove Aß from the brain thus preventing neuronal damage. The research topic focuses on the preclinical and clinical evidence about the several factors that contribute to the pathogenesis of AD as well as the potential therapeutic role of new classes of drugs still under preclinical or clinical development
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  • 48
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    ISBN: 9782889194407
    Language: English
    Pages: 1 Online-Ressource (115 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction
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  • 49
    ISBN: 9782889196685
    Language: English
    Pages: 1 Online-Ressource (123 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This introduction just aims to be a fast foreword to the special topic now turned into an e-book. The Editorial "Decision-Making Experiments under a Philosophical Analysis: Human Choice as a Challenge for Neuroscience" alongside with my opinion article "Neurophilosophical considerations on decision making: Pushing-up the frontiers without disregarding their foundations" play the real role of considering in more details the articles and the whole purpose of this e-book. What I must highlight in this foreword is that our intention with such a project was to deepen into the very foundations of our current paradigms in decision neuroscience and to philosophically moot its foundations and repercussions. Normal Science (a term coined by Philosopher Thomas Kuhn) works under a research consensus among a scientific community: A shared paradigm, consolidated methods, widespread convictions. Pragmatically, winning formulas must be kept, although, not at any cost. What differentiates a gifted and revolutionary scientist from a more bureaucratic colleague is the capacity and willingness of constantly reevaluating, depurating and refining his/her own paradigm. That is best strategy to avoid that a paradigm itself would gradually come under challenge. In my view, some achievements, in this sense, were brought about in our project. The e-book will be inspiring and informative for both neuroscientists that are concerned with the very foundations of their works and for philosophers that are not blind to empirical evidence. Kant once said: “Thoughts without content are empty, intuitions without concepts are blind”. Paraphrasing Kant we could say: Philosophy without science is empty, science without philosophy is blind
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  • 50
    ISBN: 9782889195701
    Language: English
    Pages: 1 Online-Ressource (264 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The Halophiles 2013 meeting is a multidisciplinary international congress, with a strong history of regular triennial meetings since 1978. Our mission is to bring researchers from a wide diversity of investigation interests (e.g., protein and species evolution; niche adaptation, ecology, taxonomy, genomics, metagenomics, horizontal gene transfer, gene regulation; DNA replication, repair and recombination; signal transduction; community assembly and species distribution; astrobiology; biotechnological applications; adaptation to radiation, desiccation, osmotic stress) into a single forum for the integration and synthesis of ideas and data from all three domains of life, and their viruses, yet from a single environment; salt concentrations greater than seawater. This cross-section of research informs our understanding of the microbiological world in many ways. The halophilic environment is extreme, especially above 10% NaCl, restricting life solely to microbes. The microorganisms that live there are adapted to extreme conditions, and are notable for their ability to survive high doses of radiation and desiccation. Therefore, the hypersaline environment is a model system (both the abiotic, and biologic factors) for insightful understanding regarding conditions and life in the absence of plant and animals (e.g., life on the early earth, and other solar system bodies like Mars and Europa). Lower salinity conditions (e.g., 6-10% NaCl) form luxuriant microbial mats considered modern analogues of fossilized stromatolites, which are enormous microbially produced structures fashioned during the Precambrian (and still seen today in places like Shark’s Bay, Australia). Hypersaline systems are island-like habitats spread patchily across the earth’s surface, and similar to the Galapagos Islands represent unique systems excellent for studying the evolutionary pressures that shape microbial community assembly, adaptation, and speciation. The unique adaptations to this extreme environment produce valuable proteins, enzymes and other molecules capable of remediating harsh human instigated environments, and are useful for the production of biofuels, vitamins, and retinal implants, for example. This research topic is intended to capture the breadth and depth of these topics
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  • 51
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    ISBN: 9782889194971
    Language: English
    Pages: 1 Online-Ressource (215 p.)
    Series Statement: Frontiers Research Topics
    Abstract: From simple inorganic catalysts to vital biological cofactors, divalent transition metals are instrumental to electron transfers, catalysis and signaling. Their natural ability to bind, exchange and react with organic molecules including oxygen requires from living cells to regulate uptake with metabolic activities, sensing and chaperoning, distributing and storing, or excreting excess to prevent detrimental biochemical reactions. Since transition metal deficiency and overload both limit cell growth it is no surprise that the immune system evolved a dual strategy, of metal starvation or intoxication, to thwart microbial invasions. Like environmental metal availability determined biological use it also shaped host-microbe metal economy: Fe and Mn, available early in evolution and still required rather ubiquitously, are generally withheld by host in response to infection; Zn and Cu, which became bioavailable later, essentially to eukaryotic cells may be bombarded toward invaders. Successful microbial pathogens have evolved elaborate counter-measures to cope with host metal defenses. This research topic aims to review and discuss metal currencies in host-microbe interactions focusing on new findings about micro-organism pathogenesis determinants in the face of host innate strategies to interfere with microbial physiology
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  • 52
    ISBN: 9782889195268
    Language: English
    Pages: 1 Online-Ressource (224 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens
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  • 53
    ISBN: 9782889196494
    Language: English
    Pages: 1 Online-Ressource (174 p.)
    Series Statement: Frontiers Research Topics
    Abstract: By means of this ‘Frontie ...
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  • 54
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    ISBN: 9782889194940
    Language: English
    Pages: 1 Online-Ressource (120 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes
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  • 55
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    ISBN: 9782889195572
    Language: English
    Pages: 1 Online-Ressource (114 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The interplay between hos ...
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  • 56
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    ISBN: 9782889195787
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Many of the most prevalent and devastating human and animal pathogens have part of their lifecycle out-with the animal host. These pathogens have a remarkably wide capacity to adapt to a range of quite different environments: physical, chemical and biological, which is part of the key to their success. Many of the well-known pathogens that are able to jump between hosts in different biological kingdoms are transmitted through the faecal-oral and direct transmission pathways, and as such have become important food-borne pathogens. Some high-profile examples include fresh produce-associated outbreaks of Escherichia coli O157:H7 and Salmonella enterica. Other pathogens may be transmitted via direct contact or aerosols are include important zoonotic pathogens. It is possible to make a broad division between those pathogens that are passively transmitted via vectors and need the animal host for replication (e.g. virus and parasites), and those that are able to actively interact with alternative hosts, where they can proliferate (e.g. the enteric bacteria). This research topic will focus on plants as alternative hosts for human pathogens, and the role of plants in their transmission back to humans. The area is particularly exciting because it opens up new aspects to the biology of some microbes already considered to be very well characterised. One aspect of cross-kingdom host colonisation is in the comparison between the hosts and how the microbes are able to use both common and specific adaptations for each situation. The area is still in relative infancy and there are far more questions than answers at present. We aim to address important questions underlying the interactions for both the microbe and plant host in this research topic
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  • 57
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    ISBN: 9782889195237
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Attachment theory, assessment and research offers a broad, far-reaching view of human functioning, and it can enrich a psychologist's understanding of subjects and their relational adjustment, both in clinical and non-clinical settings. Ongoing research in attachment has led to a number of individual treatments and prevention and intervention programs. The assessment of an individual's attachment organization, can play a crucial role in explaining and previewing the unfolding treatment, the relational adjustments or concerns, and the psychological well-being. We hope to receive empirical papers that give evidence for the usefulness of attachment assessment in both clinical (e.g., patients with Eating Disorder; or Axis-II; psychotherapy patients…) or not clinical population (e.g. Adoptive and/or foster families or couples, Mother-infant assessment in prevention field…). These papers should include methodological issues and information about the participants, the methods used to assess attachment, the process of scorer training and the availability of the manual used to obtain inter-scorer reliability. Case studies may be of interest to the extent that they demonstrate the value of a systematic approach to attachment material. A range of theoretical perspectives is welcome as well presentation of new emergent tools on attachment. Because Frontiers in Psychology is an international journal, each empirical paper should comment on the international implications of the findings and discuss its cross-cultural use. Such comments may include, for example, its linguistic specificity, its robustness in translation, and the cross-cultural generalizability of the constructs and behaviors of the measure and its usual correlates. Cross-cultural generalizability is not, however, a requirement
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  • 58
    ISBN: 9782889196074
    Language: English
    Pages: 1 Online-Ressource (80 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There is extensive eviden ...
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  • 59
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    ISBN: 9782889195381
    Language: English
    Pages: 1 Online-Ressource (176 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Pathogens adapt their metabolism rapidly to the host. Our topic covers these phenomenon regarding extracellular and intracellular pathogens as well as general methods to elucidate different metabolic adaptation processes - an essential guide for any scientist wanting to keep abreast of recent developments in infection biology
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  • 60
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    ISBN: 9782889194957
    Language: English
    Pages: 1 Online-Ressource (164 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Conflict adaptation theory is one of the most popular theories in cognitive psychology. The theory argues that participants strategically modulate attention away from distracting stimulus features in response to conflict. Although results with proportion congruent, sequential congruency, and similar paradigms seem consistent with the conflict adaptation view, some researchers have expressed scepticism. The paradigms used in the study of conflict adaptation require the manipulation of stimulus frequencies, sequential dependencies, time-on-task regularities, and various other task regularities that introduce the potential for learning of conflict-unrelated information. This results in the unintentional confounding of measures of conflict adaptation with simpler learning and memory biases. There are also alternative accounts which propose that attentional adaptation does occur, but via different mechanisms, such as valence, expectancy, or effort. A significant (and often heated) debate remains surrounding the question of whether conflict adaptation exists independent of these alternative mechanisms of action. The aim of this Research Topic is to provide a forum for current directions in this area, considering perspectives from all sides of the debate
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  • 61
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    ISBN: 9782889195244
    Language: English
    Pages: 1 Online-Ressource (479 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protein, lipid and DNA oxidation, leads to Fe-mediated programmed cell death and organ dysfunction. Major and systemic Fe overloads occurring in hemochromatosis and Fe-loading anemias have been extensively studied. However, localized tissue Fe overload was recently associated to a variety of pathologies, such as infection, inflammation, cancer, cardiovascular and neurodegenerative disorders. In keeping with the existence of cross-regulatory interactions between Fe homeostasis and the pathophysiology of these diseases, further investigations on the mechanisms that provide cellular and systemic adaptation to tissue Fe overload are instrumental for future therapeutic approaches. Thus, we encourage our colleagues to submit original research papers, reviews, perspectives, methods and technology reports to contribute their findings to a current state of the art on a comprehensive overview of the importance of iron metabolism in pathophysiologic conditions
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  • 62
    ISBN: 9782889194919
    Language: English
    Pages: 1 Online-Ressource (86 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients
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  • 63
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    ISBN: 9782889197095
    Language: English
    Pages: 1 Online-Ressource (76 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The title follows from the original demonstration by Dr. Hugh de Wardener in 1961 that a humoral agent is produced after extracellular volume expansion which results in a vigorous diuresis and natriuresis. Thus the name of "natriuretic hormone" was coined. In the years that followed several investigators pursued the search for the hormone. What resulted, however, was the discovery of several hormones with different characteristics, all of which were natriuretic. Initially it was found that the hormone was similar in action to ouabain or digoxin, hence the appelation of ouabain-like or digoxin-like. The hormone was found to be an inhibitor of Na-K-ATPase, which would fit with it being a cardiotonic steroid. On the other hand, neither ouabain or digoxin migrated on Sephadex gel filtration in the same locus as the hormone. Other investigators claim to have identified the hormone-initially as a vanadium-diascorbate, later as bufadienolides such as marinobufagenin, yet later as a macrocylic derivative of inorganic carbon suboxide with a molecular weight of 408 Da. Some support for the latter finding was derived from an earlier report that a semi-purified Sephadex-derived compound was found to have a molecular weight of about 12,000 Da but the active compound, when split from its carrier protein, had a molecular weight of exactly 408 Da. This compound had not been further identified. As further development was the demonstration by Bricker and colleagues that a natriuretic substance could be purified from uremic urine. This turned out to be a xathurenic acid derivative. Meanwhile the focus began to turn to natriuretic peptides derived from heart (ANF and BNP). These peptides have a shorter duration of action than the cardiotonic steroid-like hormone and ANF has proved to be most useful as a measure of heart failure. It should also be stressed that marinobufagenin, like ANF, is elevated in congestive heart failure, whereas the steroid-like hormone is depressed or absent in this state. This review will attempt to describe and contrast the properties of each of the proposed natriuretic hormones, including their locus on Sephadex separation, potency, duration of action, chemical structure (if known), behavior in hypertension, renal failure, heart failure, and brain disease. As most recent work has focussed on marinobufagenin, this hormone will be brought up to date by investigators in the field
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  • 64
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    ISBN: 9782889195558
    Language: English
    Pages: 1 Online-Ressource (86 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Early in the 80’s date the first observations on the existence of hormonal steroids that may be synthesized and act in the nervous system. In order to refer to these endogenous steroids, proved important to control both central and peripheral nervous system, it was proposed the term “neurosteroids” (NSs). Over the years, their importance in regulating the physiological functions of neuronal and glial cells increased progressively. These steroids can be involved in several pathophysiological conditions such as depression, anxiety, premenstrual syndrome (PMS), schizophrenia and Alzheimer disease. Among the different classes of NSs, the progestagens revealed particularly important. The progesterone metabolite 5a-pregnan-3a-ol-20-one, also named tetrahydroprogesterone or allopregnanolone (ALLO) was one of the first most important steroid that was originally shown to act as neurosteroid. ALLO is synthesized through the action of the 5aR-3a-HSD, which converts P into DHP and subsequently, via a bidirectional reaction, into ALLO. NSs exert complex effects in the nervous system through ‘classic’, genomic, and ‘non-classic’, non-genomic actions. ALLO displays a rapid ‘non-genomic’ effect, which mainly involves the potent modulation of the GABA type A (GABA-A) receptor function. Recently a membrane receptor has been identified as target for ALLO effects, i.e. the membrane progesterone receptors (mPRs) that are able to activate a signalling cascade through G protein dependent mechanisms. By these ways, ALLO is able to modulate several cell functions, acting as neurogenic molecule on neural progenitor cells, as well as by activating proliferation and differentiation of glial cells in the central and peripheral nervous system. In this topic, we review the most recent acquisitions in the field of neurosteroids, focusing our attention on ALLO because its effects on the physiology of neurons and glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues and for the treatment of neuropsychiatric disorders
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  • 65
    ISBN: 9782889194582
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry
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  • 66
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    ISBN: 9782889194933
    Language: English
    Pages: 1 Online-Ressource (120 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Phage biology is one of the most significant and fundamental aspects of biological research and is often used as a platform for model studies relating to more complex biological entities. For this reason, phage biology has enjoyed focused attention and significant advances have been made in the areas of phage genomics, transcriptomics and the development and characterisation of phage-resistance mechanisms. In recent years, considerable research has been performed to increase our understanding of the interactions of these phages with their hosts using genomic, biochemical and structural approaches. Such multidisciplinary approaches are core to developing a full understanding of the processes that govern phage infection, information that may be harnessed to develop anti-phage strategies that may be applied in food fermentations or applied in a positive sense in phage therapy applications. The co-evolutionary processes of these phages and their hosts have also been a considerable focus of research in recent years. Such data has promoted a deeper understanding of the means by which these phages attach to and infect their hosts and permitted the development of effective anti-phage strategies. Furthermore, the presence and activity of host-encoded phage-resistance systems that operate at various stages of the phage cycle and the potential for the application of such systems consolidates the value of research in this area. Conversely, phages and their components have been applied as therapeutic agents against a number of pathogens including, among others, Clostridium difficile, Lactococcus garviae, Mycobacterium spp., Listeria spp. and the possibilities and limitations of these systems will be explored in this topic. Additionally, phage therapeutic approaches have been applied to the prevention of development of food spoilage organisms in the brewing and beverage sectors and exhonorate the positive applications of phages in the industrial setting. This research topic is aimed to address the most current issues as well as the most recent advances in the research of phages infecting Gram-positive bacteria covering areas such as phages in food fermentations, their impact in industry, phage ecology, genomics, evolution, structural analysis, phage-host interactions and the application of phages and components thereof as therapeutic agents against human and animal pathogens
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  • 67
    ISBN: 9782889196265
    Language: English
    Pages: 1 Online-Ressource (211 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Accumulating evidence suggests that the cerebellum subserves functions beyond the sensorimotor realm. This possibility has received considerable attention during the past quarter century, with recent findings revealing putative cerebellar roles in cognition, emotion and spatial navigation. These functions are potentially underpinned by the behaviour-dependent formation of functional networks in which the cerebellum forms one node of distributed circuits spanning thalamic, limbic and neocortical regions. However, these views are not universally accepted. Therefore, the over-arching aim of this Research Topic was to provide a forum through which the debate on the role of cerebellar interactions with motor and "non-motor" structures can be pursued in a rigorous manner. In particular, we aimed to bring together findings from the clinical, animal, theoretical and neuroimaging fields
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  • 68
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    ISBN: 9782889195794
    Language: English
    Pages: 1 Online-Ressource (173 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Synaesthesia is a condition in which a stimulus elicits an additional subjective experience. For example, the letter E printed in black (the inducer) may trigger an additional colour experience as a concurrent (e.g., blue). Synaesthesia tends to run in families and thus, a genetic component is likely. However, given that the stimuli that typically induce synaesthesia are cultural artefacts, a learning component must also be involved. Moreover, there is evidence that synaesthetic experiences not only activate brain areas typically involved in processing sensory input of the concurrent modality; synaesthesia seems to cause a structural reorganisation of the brain. Attempts to train non-synaesthetes with synaesthetic associations have been successful in mimicking certain behavioural aspects and posthypnotic induction of synaesthetic experiences in non-synaesthetes has even led to the according phenomenological reports. These latter findings suggest that structural brain reorganization may not be a critical precondition, but rather a consequence of the sustained coupling of inducers and concurrents. Interestingly, synaesthetes seem to be able to easily transfer synaesthetic experiences to novel stimuli. Beyond this, certain drugs (e.g., LSD) can lead to synaesthesia-like experiences and may provide additional insights into the neurobiological basis of the condition. Furthermore, brain damage can both lead to a sudden presence of synaesthetic experiences in previously non-synaesthetic individuals and a sudden absence of synaesthesia in previously synaesthetic individuals. Moreover, enduring sensory substitution has been effective in inducing a kind of acquired synaesthesia. Besides informing us about the cognitive mechanisms of synaesthesia, synaesthesia research is relevant for more general questions, for example about consciousness such as the binding problem, about crossmodal correspondences and about how individual differences in perceiving and experiencing the world develop. Hence the aim of the current Research Topic is to provide novel insights into the development of synaesthesia both in its genuine and acquired form. We welcome novel experimental work and theoretical contributions (e.g., review and opinion articles) focussing on factors such as brain maturation, learning, training, hypnosis, drugs, sensory substitution and brain damage and their relation to the development of any form of synaesthesia
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  • 69
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    ISBN: 9782889195411
    Language: English
    Pages: 1 Online-Ressource (125 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cognitive processing is commonly conceptualized as being restricted to the cerebral cortex. Accordingly, electrophysiology, neuroimaging and lesion studies involving human and animal subjects have almost exclusively focused on defining roles for cerebral cortical areas in cognition. Roles for the thalamus in cognition have been largely ignored despite the fact that the extensive connectivity between the thalamus and cerebral cortex gives rise to a closely coupled thalamo-cortical system. However, in recent years, growing interest in the thalamus as much more than a passive sensory structure, as well as methodological advances such as high-resolution functional magnetic resonance imaging of the thalamus and improved electrode targeting to subregions of thalamic nuclei using electrical stimulation and diffusion tensor imaging, have fostered research into thalamic contributions to cognition. Evidence suggests that behavioral context modulates processing in primary sensory, or first-order, thalamic nuclei (for example, the lateral geniculate and ventral posterior nuclei), allowing attentional filtering of incoming sensory information at an early stage of brain processing. Behavioral context appears to more strongly influence higher-order thalamic nuclei (for example, the pulvinar and mediodorsal nucleus), which receive major input from the cortex rather than the sensory periphery. Such higher-order thalamic nuclei have been shown to regulate information transmission in frontal and higher-order sensory cortex according to cognitive demands. This Research Topic aims to bring together neuroscientists who study different parts of the thalamus, particularly thalamic nuclei other than the primary sensory relays, and highlight the thalamic contributions to attention, memory, reward processing, decision-making, and language. By doing so, an emphasis is also placed on neural mechanisms common to many, if not all, of these cognitive operations, such as thalamo-cortical interactions and modulatory influences from sources in the brainstem and basal ganglia. The overall view that emerges is that the thalamus is a vital node in brain networks supporting cognition
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  • 70
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    ISBN: 9782889194537
    Language: English
    Pages: 1 Online-Ressource (144 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Scientists and clinicians interested in cerebrovascular physiology in humans now have numerous possibilities to monitor, invasively or non-invasively, the oxygenation status of cerebral tissue. Monitoring cerebral oxygenation has several utilities; to improve patient outcome, to better understand the mechanisms underlying orthostatic hypotension; to provide insight into functional neurovascular coupling; to evaluate the influence of vasopressors on cerebral oxygen levels in patients under anesthesia; and to study the limitations of exercise tolerance. This themed research topic, through theoretical and experimental papers, covers new and exciting issues related to the study of cerebral oxygenation in health and disease. This e-book includes manuscripts inclusive of original research, methodologies and reviews in the field of integrative physiology, cognitive testing, orthostatic stress, exercise physiology and anesthesia
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  • 71
    ISBN: 9782889196791
    Language: English
    Pages: 1 Online-Ressource (283 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances
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  • 72
    ISBN: 9782889196623
    Language: English
    Pages: 1 Online-Ressource (77 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies
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  • 73
    ISBN: 9782889196432
    Language: English
    Pages: 1 Online-Ressource (112 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field
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  • 74
    ISBN: 9782889193783
    Language: English
    Pages: 1 Online-Ressource (189 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The study of plant-microbe associations by new techniques has significantly improved our understanding of the structure and specificity of the plant microbiome. Yet, microbiome function and the importance of the plant’s microbiome in the context of human and plant health are largely unexplored. Comparable with our human microbiome, millions of microbes inhabit plants, forming complex ecological communities that influence plant growth and health through its collective metabolic activities and host interactions. Viewing the microbiota from an ecological perspective can provide insight into how to promote plant health and stress tolerance of their hosts or how to adapt to a changing climate by targeting this microbial community. Moreover, the plant microbiome has a substantial impact on human health by influencing our gut microbiome by eating raw plants such as lettuce and herbs but also by influencing the microbiome of our environment through airflow. This research topic comprising reviews, original and opinion articles highlights the current knowledge regarding plant microbiomes, their specificity, diversity and function as well as all aspects studying the management of plant microbiomes to enhance plant growth, health quality and stress tolerance
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  • 75
    ISBN: 9782889195152
    Language: English
    Pages: 1 Online-Ressource (319 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Research on visual percep ...
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  • 76
    ISBN: 9782889194735
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Series Statement: Frontiers Research Topics
    Abstract: From the moment of birth, humans and animals are immersed in time: all experiences and actions evolve in time and are dynamically structured. The perception of time is thus a capacity indispensable for the control of perception, cognition and action. The last 10 years have witnessed a remarkable resurgence of interest in timing and time perception, with a continuously increasing number of researchers exploring these innate abilities. However, existing robotic systems largely neglect the key role of time in cognition and action. This is a major barrier for accomplishing the long-term goal of symbiotic human-robot interaction. The critical question is: how is time instantiated in a biological system and how can it be implemented in an artificial system? Recent years have for example seen an increasing focus on the relationship between affective states and the experience of time. The influence of affective states on subjective time seems to depend on the embodiment of emotions: intertwined affective and interoceptive states may create our subjective experience of time. Since robotic systems are in essence embodied information-processing systems that interact with the real world, we hope to inspire a reciprocal exchange of ideas between the field of Robotics and the Cognitive Neurosciences. In this research topic, we call researchers from different disciplines (Robotics, Neurosciences, and Psychology) to present their empirical work, their models or reviews on the question of how time judgments are instantiated in biological and artificial systems. Of particular interest are papers on time perception in humans and animals, with a focused interest on embodied time perception, i.e. the influence of affective and body states on time judgments. Moreover, the present Research Topic seeks to gather papers discussing the key role of time on different aspects of robotic cognition as well as modeling approaches. We are interested in paving the way for a new generation of intelligent computational systems that incorporate the sense of time in their processing loop and thus accomplish more efficient and more advanced cognitive capacities
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  • 77
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    ISBN: 9782889196548
    Language: English
    Pages: 1 Online-Ressource (105 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling
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  • 78
    ISBN: 9782889196852
    Language: English
    Pages: 1 Online-Ressource (123 p.)
    Series Statement: Frontiers Research Topics
    Abstract: One of the key features o ...
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  • 79
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    ISBN: 9782889196388
    Language: English
    Pages: 1 Online-Ressource (102 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on structural and computational approaches to understanding carbohydrate recognition by proteins involved in immunity and infection. Particular areas of focus include cancer immunotherapeutics, carbohydrate-lectin interactions, glycosylation and glycosyltransferases
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  • 80
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    ISBN: 9782889194360
    Language: English
    Pages: 1 Online-Ressource (97 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Endoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. A number of biochemical, physiological, or pathological stimuli can interrupt protein folding process, causing accumulation of unfolded or misfolded proteins in the ER lumen, a condition called “ER stress”. To cope with accumulation of unfolded or misfolded proteins, the ER has evolved a group of signaling pathways termed “Unfolded Protein Response (UPR)” or “ER stress response” to align cellular physiology. To maintain ER homeostasis, transcriptional regulation mediated through multiple UPR branches is orchestrated to increase ER folding capacity, reduce ER workload, and promote degradation of misfolded proteins. In recent years, accumulating evidence suggests that ER stress-triggered transcriptional reprogramming exists in many pathophysiological processes and plays fundamental roles in the initiation and progression of a variety of diseases, such as metabolic disease, cardiovascular disease, neurodegenerative disease, and cancer. Understanding effects and mechanisms of ER stressassociated transcriptional reprogramming has high impact on many areas of molecular genetics and will be particularly informative to the development of pharmacologic avenues towards the prevention and treatment of modern common human diseases by targeting the UPR signaling. For these reasons, ER stress response and transcriptional reprogramming are a timely and necessary topic of discussion for Frontiers in Genetics. The important topics in this area include but not limited to: (1) ER-resident transcription factors and their involvements in ER stress response and cell physiology; (2) Physiologic roles and molecular mechanisms of ER stress-associated transcriptional regulation in lipid and glucose metabolism; (3) In vitro and in vivo models for ER stress-associated transcriptional reprogramming; (4) ER stress-associated transcriptional regulation in human disease; (5) Therapeutic potentials by targeting ER stress response pathways
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  • 81
    ISBN: 9782889196180
    Language: English
    Pages: 1 Online-Ressource (248 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Zoonoses are currently co ...
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  • 82
    ISBN: 9782889195688
    Language: English
    Pages: 1 Online-Ressource (95 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In September 2011, scientists announced new experimental findings that would not only threaten the conduct and publication of influenza research, but would have significant policy and intelligence implications. The findings presented a modified variant of the H5N1 avian influenza virus (hereafter referred to as the H5N1 virus) that was transmissible via aerosol between ferrets. These results suggested a worrisome possibility: the existence of a new airborne and highly lethal H5N1 virus that could cause a deadly global pandemic. In response, a series of international discussions on the nature of dual-use life science arose. These discussions addressed the complex social, technical, political, security, and ethical issues related to dual-use research. This Research Topic will be devoted to contributions that explore this matrix of issues from a variety of case study and international perspectives
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  • 83
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    ISBN: 9782889195404
    Language: English
    Pages: 1 Online-Ressource (375 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Efficient auditory processing requires the rapid integration of transient sensory inputs. This is exemplified in human speech perception, in which long stretches of a complex acoustic signal are typically processed accurately and essentially in real-time. Spoken language thus presents listeners’ auditory systems with a considerable challenge even when acoustic input is clear. However, auditory processing ability is frequently compromised due to congenital or acquired hearing loss, or altered through background noise or assistive devices such as cochlear implants. How does loss of sensory fidelity impact neural processing, efficiency, and health? How does this ultimately influence behavior? This Research Topic explores the neural consequences of hearing loss, including basic processing carried out in the auditory periphery, computations in subcortical nuclei and primary auditory cortex, and higher-level cognitive processes such as those involved in human speech perception. By pulling together data from a variety of disciplines and perspectives, we gain a more complete picture of the acute and chronic consequences of hearing loss for neural functioning
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  • 84
    ISBN: 9782889193776
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Sigmund Freud was a train ...
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  • 85
    ISBN: 9782889196777
    Language: English
    Pages: 1 Online-Ressource (388 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The huge volume of multi-modal neuroimaging data across different neuroscience communities has posed a daunting challenge to traditional methods of data sharing, data archiving, data processing and data analysis. Neuroinformatics plays a crucial role in creating advanced methodologies and tools for the handling of varied and heterogeneous datasets in order to better understand the structure and function of the brain. These tools and methodologies not only enhance data collection, analysis, integration, interpretation, modeling, and dissemination of data, but also promote data sharing and collaboration. This Neuroinformatics Research Topic aims to summarize the state-of-art of the current achievements and explores the directions for the future generation of neuroinformatics infrastructure. The publications present solutions for data archiving, data processing and workflow, data mining, and system integration methodologies. Some of the systems presented are large in scale, geographically distributed, and already have a well-established user community. Some discuss opportunities and methodologies that facilitate large-scale parallel data processing tasks under a heterogeneous computational environment. We wish to stimulate on-going discussions at the level of the neuroinformatics infrastructure including the common challenges, new technologies of maximum benefit, key features of next generation infrastructure, etc. We have asked leading research groups from different research areas of neuroscience/neuroimaging to provide their thoughts on the development of a state of the art and highly-efficient neuroinformatics infrastructure. Such discussions will inspire and help guide the development of a state of the art, highly-efficient neuroinformatics infrastructure
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  • 86
    ISBN: 9782889196999
    Language: English
    Pages: 1 Online-Ressource (68 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Noninvasive brain stimula ...
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  • 87
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    ISBN: 9782889194681
    Language: English
    Pages: 1 Online-Ressource (115 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Pancreatic Cancer has bee ...
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  • 88
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    ISBN: 9782889194445
    Language: English
    Pages: 1 Online-Ressource (99 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Ronald Fisher needed to develop elaborate models of genetic effects in order to set the foundations of Quantitative Genetics in his 1918 paper “The correlation between relatives on the supposition of Mendelian inheritance”. Since then, many significant implementations have been made to model genetic effects. However, at the verge of one century after Fisher’s kick-off, models of genetic effects keep on being discussed and implemented. Indeed, the relatively recent advent of QTL analyses challenged the state of the art of this field by providing researchers the opportunity to obtain and analyze estimates of genetic effects from real data. In this context, the development of this field was not exempt of some polemics, like the debate about the convenience of the functional and the statistical epistasis approaches. This research topic is meant to provide recent developments in models and estimation of genetic effects and to enrich the discussion about how and why models of genetic effects must be further developed and applied. The articles in this Research Topic shall thus extend, refine and/or provide a refresh look at Fisher’s original models of genetic effects and their application to genetic effects estimation and to improve our understanding of evolutionary processes and breeding programs
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  • 89
    ISBN: 9782889194889
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This Research Topic combines articles aiming to gain a better understanding on different factors that determine whether people are successful or not in controlling computerized devices with brain signals. Since decades, technological advancements in neuroscience allow the interpretation of brain signals and their translation into control messages (Brain-computer interface (BCI)). Moreover, the control of brain signals can be used to induce changes in cognition and behavior (Neurofeedback (NF)). However, the break-through of this technology for the broad population in real-world applications has not yet arrived. Various factors have been related to the individual success in controlling computerized devices with brain signals, but to date, no general theoretical framework is available. In this Research Topic, aspects of the training protocol such as instructions, task and feedback as well as cognitive and psychological traits such as motivation, mood, locus of control and empathy are investigated as determinants of BCI or NF performance. Moreover, the mechanisms and networks involved in gaining and maintaining control over brain activity as well as its prediction are addressed. Finally, as the ultimate goal of this research is to use BCI and NF for communication or control and therapy, respectively, novel applications for individuals with disabilities or disorders are discussed
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  • 90
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    ISBN: 9782889196272
    Language: English
    Pages: 1 Online-Ressource (125 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Interaction between language and cognition remains an unsolved scientific problem. What are the differences in neural mechanisms of language and cognition? Why do children acquire language by the age of six, while taking a lifetime to acquire cognition? What is the role of language and cognition in thinking? Is abstract cognition possible without language? Is language just a communication device, or is it fundamental in developing thoughts? Why are there no animals with human thinking but without human language? Combinations even among 100 words and 100 objects (multiple words can represent multiple objects) exceed the number of all the particles in the Universe, and it seems that no amount of experience would suffice to learn these associations. How does human brain overcome this difficulty?
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  • 91
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    ISBN: 9782889195534
    Language: English
    Pages: 1 Online-Ressource (87 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Though traditionally designed for entertainment, video games are being used more and more by psychologists to understand topics such as skill acquisition, cognitive capacity and plasticity, aging, individual differences, and development. The appeal of using video games over simpler laboratory paradigms partly comes from their ability to present rich and complex cognitive challenges more representative of the demands of the complex everyday tasks we perform outside of the laboratory. However, this complexity also presents a host of methodological and analytic challenges. This Research Topic brings together research using games to explore cognitive processes, with a special focus on the challenges of this approach. Challenges are in terms of design, implementation, or data analysis
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  • 92
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    ISBN: 9782889195763
    Language: English
    Pages: 1 Online-Ressource (116 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The oral cavity harbors a ...
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  • 93
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    ISBN: 9782889193943
    Language: English
    Pages: 1 Online-Ressource (95 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. This e-Book "PAIN - Novel targets and new technologies" has brought together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies across the various types of pain. This information is presented as novel research findings, short communications and review articles. The goal of this e-Book is to generate further collaborative discussion on the future and direction of pain therapies
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  • 94
    ISBN: 9782889196937
    Language: English
    Pages: 1 Online-Ressource (109 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Silicon photonics technology, which has the DNA of silicon electronics technology, promises to provide a compact photonic integration platform with high integration density, mass-producibility, and excellent cost performance. This technology has been used to develop and to integrate various photonic functions on silicon substrate. Moreover, photonics-electronics convergence based on silicon substrate is now being pursued. Thanks to these features, silicon photonics will have the potential to be a superior technology used in the construction of energy-efficient cost-effective apparatuses for various applications, such as communications, information processing, and sensing. Considering the material characteristics of silicon and difficulties in microfabrication technology, however, silicon by itself is not necessarily an ideal material. For example, silicon is not suitable for light emitting devices because it is an indirect transition material. The resolution and dynamic range of silicon-based interference devices, such as wavelength filters, are significantly limited by fabrication errors in microfabrication processes. For further performance improvement, therefore, various assisting materials, such as indium-phosphide, silicon-nitride, germanium-tin, are now being imported into silicon photonics by using various heterogeneous integration technologies, such as low-temperature film deposition and wafer/die bonding. These assisting materials and heterogeneous integration technologies would also expand the application field of silicon photonics technology. Fortunately, silicon photonics technology has superior flexibility and robustness for heterogeneous integration. Moreover, along with photonic functions, silicon photonics technology has an ability of integration of electronic functions. In other words, we are on the verge of obtaining an ultimate technology that can integrate all photonic and electronic functions on a single Si chip. This e-Book aims at covering recent developments of the silicon photonic platform and novel functionalities with heterogeneous material integrations on this platform
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  • 95
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    ISBN: 9782889194223
    Language: English
    Pages: 1 Online-Ressource (130 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Our sense of smell pervasively influences our most common behaviors and daily experience, yet little is known about olfactory consciousness. Over the past decade and a half research in both the fields of Consciousness Studies and Olfaction has blossomed, however, olfactory consciousness has received little to no attention. The olfactory systems unique anatomy, functional organization, sensory processes, and perceptual experiences offers a fecund area for exploring all aspects of consciousness, as well as a external perspective for re-examining the assumptions of contemporary theories of consciousness. It has even been suggested that the olfactory system may represent the minimal neuroanatomy that is required for conscious processing. Given the variegated nature of research on consciousness, we include original papers concerning the nature of olfactory consciousness. The scope of the special edition widely incorporates olfaction as it relates to Consciousness, Awareness, Attention, Phenomenal- or Access-Consciousness, and Qualia. Research concerning olfaction and cross-modal integration as it relates to conscious experience is also address. As the initial foray into this uncharted area of research, we include contributions from across all disciplines contributing to cognitive neuroscience, including neurobiology, neurology, psychology, philosophy, linguistics, and computer sciences. It is our hope that this Research Topic will serve as the impetus for future interdisciplinary research on olfaction and consciousness
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  • 96
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    ISBN: 9782889196722
    Language: English
    Pages: 1 Online-Ressource (86 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Testicular cancer (TC) is ...
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  • 97
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    ISBN: 9782889194674
    Language: English
    Pages: 1 Online-Ressource (122 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Coordinated cell interact ...
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  • 98
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    ISBN: 9782889194346
    Language: English
    Pages: 1 Online-Ressource (99 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders
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  • 99
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    ISBN: 9782889193851
    Language: English
    Pages: 1 Online-Ressource (484 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The inferior colliculus (IC) is a unique structure in the auditory system, located between the primary auditory nuclei of the brainstem and the thalamus. The existence of the complex neural circuits in the auditory brainstem and midbrain, lacking in other sensory systems, has motivated an outpouring of research on the circuitry and physiological properties of the IC. IC neurons receive ascending inputs from over 20 separate sources in the brainstem as well as a dense collection of descending connections from the cortex. It is richly connected to both the left and right ears through these circuits and a major theme in research on the IC has been its role in binaural interactions. A second theme is the role of descending circuits in modulating responses to sound in the IC. A third theme is understanding the sound processing that occurs at the level of the IC, essentially how the representation of sound in the IC differs from that in the two auditory nerves. The representation of sound in the IC is an intermediate step in the development of the cortical representation as well as in the development of many perceptual features of sounds. These characteristics have been documented for a number of computations, including sound localization, masking properties, robustness of the representation, and responses to temporal and spectral properties of sounds. This Research Topic aims to discuss a wide range of aspects of the structure and function of the IC in a way that will facilitate future research
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  • 100
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    ISBN: 9782889195503
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The release of cytokines, chemokines, and other immune-modulating mediators released from innate immune cells, including eosinophils, neutrophils, macrophages, dendritic cells, mast cells, and epithelial cells, is an important event in immunity. Cytokine synthesis and transportation occurs through the canonical protein trafficking pathway associated with endoplasmic reticulum and Golgi. How cytokines are released upon their exit from the trans-Golgi network varies enormously between cell types, and in many cells this has not yet been characterized. This issue delves into the plethora of cytokines released by innate immune cells, and where possible, shines light on specific mechanisms that regulate trafficking and release of Golgi-derived vesicles. Each cell type also shows varying degrees of dependency on microtubule organization and actin cytoskeleton remodeling for cytokine secretion. Understanding the mechanisms of cytokine secretion will reveal the inner workings of individual innate immune cell types, and allow identification of critical regulatory steps in cytokine release
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