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  • 2010-2014  (27)
  • 2005-2009
  • 2012  (27)
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (27)
  • Boston, MA : Safari
  • Medical genetics  (27)
Datasource
Material
Language
Years
  • 2010-2014  (27)
  • 2005-2009
Year
Author, Corporation
Publisher
Keywords
  • 1
    Online Resource
    Online Resource
    Viral Genomes : Molecular Structure, Diversity, Gene Expression Mechanisms and Host-Virus Interactions (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100980 , 9789535143512
    Language: Undetermined
    Pages: 1 Online-Ressource (316 p.)
    Keywords: Medical genetics
    Abstract: Viruses are small infectious agents that can replicate only inside the living cells of susceptible organisms. The understanding of the molecular events underlying the infectious process has been of central interest to improve strategies aimed at combating viral diseases of medical, veterinary and agricultural importance. Some of the viruses cause dreadful diseases, while others are also of interest as tools for gene transduction and expression and in non-poluting insect pest management strategies. The contributions in this book provide the reader with a perspective on the wide spectrum of virus-host systems. They are organized in sections based on the major topics covered: viral genomes organization, regulation of replication and gene expression, genome diversity and evolution, virus-host interactions, including clinically relevant features. The chapters also cover a wide range of technical approaches, including high throughput methods to assess genome variation or stability. This book should appeal to all those interested in fundamental and applied aspects of virology
    Note: English
    URL: kostenfrei
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  • 2
    Online Resource
    Online Resource
    Genetic Diversity in Microorganisms (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100645 , 9789535143444
    Language: Undetermined
    Pages: 1 Online-Ressource (384 p.)
    Keywords: Medical genetics
    Abstract: Genetic Diversity in Microorganisms presents chapters revealing the magnitude of genetic diversity of microorganisms living in different environmental conditions. The complexity and diversity of microbial populations is by far the highest among all living organisms. The diversity of microbial communities and their ecologic roles are being explored in soil, water, on plants and in animals, and in extreme environments such as the arctic deep-sea vents or high saline lakes. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in microorganisms. The purpose of the book is to provide a glimpse into the dynamic process of genetic diversity of microorganisms by presenting the thoughts of scientists who are engaged in the generation of new ideas and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of microbial phylogeny, genetic diversity, and molecular biology
    Note: English
    URL: kostenfrei
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  • 3
    Online Resource
    Online Resource
    Autoimmune Diseases : Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106937 , 9789535170204
    Language: English
    Pages: 1 Online-Ressource (404 p.)
    Keywords: Medical genetics
    Abstract: Autoimmune disease represents a group of more than 60 different chronic autoimmune diseases that affect approximately 6% of the population. Autoimmune diseases arise when ones immune system actively targets and destroys self tissue resulting in clinical disease with prime examples such as Lupus and Type 1 diabetes. The immune system is designed to protect us from foreign pathogens such as viruses and bacteria. However, during the process of generating immune cells for this purpose, as a negative consequence, self-reactive immune cells are also generated. This book aims to present the latest knowledge and insights regarding the different contributing factors and their interplay, discussions on several autoimmune diseases and their case studies, and therapeutic treatments, including stem cell, for autoimmune diseases
    Note: English
    URL: kostenfrei
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  • 4
    Online Resource
    Online Resource
    Clinical Flow Cytometry : Emerging Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535105756 , 9789535152958
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Medical genetics
    Abstract: "Clinical Flow Cytometry - Emerging Applications" contains a collection of reviews and original papers that illustrate the relevance of flow cytometry for the study of specific diseases and clinical evaluations. The chapters have been contributed by authors from a wide variety of countries showing the broad application and importance of this technology in medicine. Examples include chapters on autoimmune disease, cancer, and the evaluation of new drugs. The book is intended to give newcomers a helpful introduction, but also to provide experienced flow cytometrists with novel insights and a better understanding of clinical cytometry
    Note: English
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  • 5
    Online Resource
    Online Resource
    Muscular Dystrophy (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106036 , 9789535169949
    Language: English
    Pages: 1 Online-Ressource (556 p.)
    Keywords: Medical genetics
    Abstract: With more than 30 different types and subtypes known and many more yet to be classified and characterized, muscular dystrophy is a highly heterogeneous group of inherited neuromuscular disorders. This book provides a comprehensive overview of the various types of muscular dystrophies, genes associated with each subtype, disease diagnosis, management as well as available treatment options. Though each different type and subtype of muscular dystrophy is associated with a different causative gene, the majority of them have overlapping clinical presentations, making molecular diagnosis inevitable for both disease diagnosis as well as patient management. This book discusses the currently available diagnostic approaches that have revolutionized clinical research. Pathophysiology of the different muscular dystrophies, multifaceted functions of the involved genes as well as efforts towards diagnosis and effective patient management, are also discussed. Adding value to the book are the included reports on ongoing studies that show a promise for future therapeutic strategies
    Note: English
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  • 6
    Online Resource
    Online Resource
    Point Mutation (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535103318 , 9789535152507
    Language: English
    Pages: 1 Online-Ressource (354 p.)
    Keywords: Medical genetics
    Abstract: This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world
    Note: English
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  • 7
    Online Resource
    Online Resource
    Meiosis : Molecular Mechanisms and Cytogenetic Diversity (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535101185 , 9789535152187
    Language: English
    Pages: 1 Online-Ressource (474 p.)
    Keywords: Medical genetics
    Abstract: Meiosis, the process of forming gametes in preparation for sexual reproduction, has long been a focus of intense study. Meiosis has been studied at the cytological, genetic, molecular and cellular levels. Studies in model systems have revealed common underlying mechanisms while in parallel, studies in diverse organisms have revealed the incredible variation in meiotic mechanisms. This book brings together many of the diverse strands of investigation into this fascinating and challenging field of biology
    Note: English
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  • 8
    Online Resource
    Online Resource
    Binding Protein (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535107583 , 9789535153191
    Language: English
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Medical genetics
    Abstract: Proteins are essential for all cellular events. They bind or interact with additional players such as other proteins, peptides, DNA, and RNA to exert their functions. Revealing protein binding partners is important in understanding the mechanisms through which they function in the cells and the organism. These interactions are essential in the regulation of cell fates and could be important in drugs development. For example proteins can bind mRNA to regulate stability and translation. They also bind other proteins for degradation or proteolysis. These mRNAs and proteins could be involved in cellular processes such as cell survival or apoptosis. This book contains review articles dealing with protein interactions with the above mentioned factors. The enclosed articles could be informative and stimulating for readers interested in protein binding partners and the consequences of such interactions
    Note: English
    URL: kostenfrei
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  • 9
    Online Resource
    Online Resource
    Functional Genomics (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535107279 , 9789535153160
    Language: English
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medical genetics
    Abstract: This book titled "Functional Genomics" contains a selection of chapters focused on crucial topics in functional genomics, from the analysis of the genetic code, to the understanding of the role of the different genes and to the proteomic implications. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Covering all the aspects involved in such a broad theme as functional genomics and in all its applications would be impossible within the same book. The different chapters represent a brief introduction to the topic, connecting the most promising developments in functional genomics technologies, focusing on specific applications in biomedicine, agro-food technologies and zootechniques
    Note: English
    URL: kostenfrei
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  • 10
    Online Resource
    Online Resource
    Antimicrobial Agents (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535107231 , 9789535153177
    Language: English
    Pages: 1 Online-Ressource (434 p.)
    Keywords: Medical genetics
    Abstract: This book contains precisely referenced chapters, emphasizing antibacterial agents with clinical practicality and alternatives to synthetic antibacterial agents through detailed reviews of diseases and their control using alternative approaches. The book aims at explaining bacterial diseases and their control via synthetic drugs replaced by chemicals obtained from different natural resources which present a future direction in the pharmaceutical industry. The book attempts to present emerging low cost and environmentally friendly drugs that are free from side effects studied in the overlapping disciplines of medicinal chemistry, biochemistry, microbiology and pharmacology
    Note: English
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  • 11
    Online Resource
    Online Resource
    Genetics and Pathophysiology of Essential Hypertension (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535102823 , 9789535152347
    Language: English
    Pages: 1 Online-Ressource (248 p.)
    Keywords: Medical genetics
    Abstract: This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension
    Note: English
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  • 12
    Online Resource
    Online Resource
    Aneuploidy in Health and Disease (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106081 , 9789535152965
    Language: English
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Medical genetics
    Abstract: Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging. First, it is often hard to distinguish what is a cause and what is a consequence. Secondly, aneuploidy is often associated with a persistent defect in maintenance of genome stability. Thus, working with aneuploid, unstable cells means analyzing an ever changing creature and capturing the features that persist. In the book Aneuploidy in Health and Disease we summarize the recent advances in understanding the causes and consequences of aneuploidy and its link to human pathologies
    Note: English
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  • 13
    Online Resource
    Online Resource
    DNA Sequencing : Methods and Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535105640 , 9789535152804
    Language: English
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medical genetics
    Abstract: This book illustrates methods of DNA sequencing and its application in plant, animal and medical sciences. It has two distinct sections. The one includes 2 chapters devoted to the DNA sequencing methods and the second includes 6 chapters focusing on various applications of this technology. The content of the articles presented in the book is guided by the knowledge and experience of the contributing authors. This book is intended to serve as an important resource and review to the researchers in the field of DNA sequencing
    Note: English
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  • 14
    Online Resource
    Online Resource
    Reviews on Selected Topics of Telomere Biology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535108498 , 9789535153399
    Language: English
    Pages: 1 Online-Ressource (306 p.)
    Keywords: Medical genetics
    Abstract: Telomeres, located at the ends of linear chromosomes, are essential for genome stability and integrity. Advances in telomere researches have linked telomere dysfunction with cellular aging and a number of age-related human diseases. Recent studies further expanded our knowledge of telomere functions - telomeres are shown to be important for microbial pathogen virulence and telomere proteins have important non-telomeric cellular functions. This book includes current opinions on selected aspects of telomere research and their implication, in hope to help us focus better on future studies and enhance our research progress
    Note: English
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  • 15
    Online Resource
    Online Resource
    Senescence (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535101444 , 9789535143406
    Language: English
    Pages: 1 Online-Ressource (864 p.)
    Keywords: Medical genetics
    Abstract: The book "Senescence" is aimed to describe all the phenomena related to aging and senescence of all forms of life on Earth, i.e. plants, animals and the human beings. The book contains 36 carefully reviewed chapters written by different authors, aiming to describe the aging and senescent changes of living creatures, i.e. plants and animals
    Note: English
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  • 16
    Online Resource
    Online Resource
    Methylation : From DNA, RNA and Histones to Diseases and Treatment (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535108818 , 9789535153412
    Language: English
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Medical genetics
    Abstract: Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain
    Note: English
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  • 17
    Online Resource
    Online Resource
    Mutations in Human Genetic Disease (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535107903 , 9789535153290
    Language: English
    Pages: 1 Online-Ressource (306 p.)
    Keywords: Medical genetics
    Abstract: Different types of mutation can vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture. The genomes of higher organisms are now known to contain "pervasive architectural flaws" in that certain DNA sequences are inherently mutation prone by virtue of their base composition, sequence repetitivity and/or epigenetic modification. In this volume, a number of different authors from diverse backgrounds describe how the nature, location and frequency of different types of mutation causing inherited disease are shaped in large part, and often in remarkably predictable ways, by the local DNA sequence environment
    Note: English
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  • 18
    Online Resource
    Online Resource
    Apoptosis and Medicine (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535107019 , 9789535153115
    Language: English
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medical genetics
    Abstract: This book looks at the latest research studies on apoptosis in medicine. It is divided into three sections for convenient and easy reading. The first section which comprises two chapters is an introduction of the subject of apoptosis to the uninitiated. The second section which comprises a single solitary chapter looks at apoptosis in normal physiology during bone resorption under mechanical stress. The third and the final section reviews apoptosis in a number of pathological conditions with an emphasis on cancer
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  • 19
    Online Resource
    Online Resource
    Flow Cytometry : Recent Perspectives (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106265 , 9789535153030
    Language: English
    Pages: 1 Online-Ressource (512 p.)
    Keywords: Medical genetics
    Abstract: "Flow Cytometry - Recent Perspectives" is a compendium of comprehensive reviews and original scientific papers. The contents illustrate the constantly evolving application of flow cytometry to a multitude of scientific fields and technologies as well as its broad use as demonstrated by the international composition of the contributing author group. The book focuses on the utilization of the technology in basic sciences and covers such diverse areas as marine and plant biology, microbiology, immunology, and biotechnology. It is hoped that it will give novices a valuable introduction to the field, but will also provide experienced flow cytometrists with novel insights and a better understanding of the subject
    Note: English
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  • 20
    Online Resource
    Online Resource
    Analysis of Genetic Variation in Animals (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100935 , 9789535152149
    Language: English
    Pages: 1 Online-Ressource (374 p.)
    Keywords: Medical genetics
    Abstract: Analysis of Genetic Variation in Animals includes chapters revealing the magnitude of genetic variation existing in animal populations. The genetic diversity between and within populations displayed by molecular markers receive extensive interest due to the usefulness of this information in breeding and conservation programs. In this concept molecular markers give valuable information. The increasing availability of PCR-based molecular markers allows the detailed analyses and evaluation of genetic diversity in animals and also, the detection of genes influencing economically important traits. The purpose of the book is to provide a glimpse into the dynamic process of genetic variation in animals by presenting the thoughts of scientists who are engaged in the generation of new idea and techniques employed for the assessment of genetic diversity, often from very different perspectives. The book should prove useful to students, researchers, and experts in the area of conservation biology, genetic diversity, and molecular biology
    Note: English
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  • 21
    Online Resource
    Online Resource
    Molecular Interactions (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100799 , 9789535152132
    Language: English
    Pages: 1 Online-Ressource (384 p.)
    Keywords: Medical genetics
    Abstract: In a classical approach materials science is mainly dealing with interatomic interactions within molecules, without paying much interest on weak intermolecular interactions. However, the variety of structures actually is the result of weak ordering because of noncovalent interactions. Indeed, for self-assembly to be possible in soft materials, it is evident that forces between molecules must be much weaker than covalent bonds between the atoms of a molecule. The weak intermolecular interactions responsible for molecular ordering in soft materials include hydrogen bonds, coordination bonds in ligands and complexes, ionic and dipolar interactions, van der Waals forces, and hydrophobic interactions. Recent evolutions in nanosciences and nanotechnologies provide strong arguments to support the opportunity and importance of the topics approached in this book, the fundamental and applicative aspects related to molecular interactions being of large interest in both research and innovative environments. We expect this book to have a strong impact at various education and research training levels, for young and experienced researchers from both academia and industry
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  • 22
    Online Resource
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    Studies in Population Genetics (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535105886 , 9789535169895
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Medical genetics
    Abstract: This book deals with central concepts in population genetics, describing the main evolutionary processes that influence the allele frequency distribution and change. The different chapters discuss topics such as population size and structure, migration, inbreeding and interbreeding, mechanisms of extinction and speciation, along with different data techniques and molecular methods used for detecting DNA sequence variation in the study of genetic polymorphisms. Part of the book includes statistical and computational methods commonly used to process population genetics data, which constitute an essential tool for understanding the concepts discussed. The book will be a useful reference for graduate students and researchers working on population genetics, and other related areas including microbiology, genetics, molecular biology, ecology, anthropology and others
    Note: English
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  • 23
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    Recent Trends in Cytogenetic Studies : Methodologies and Applications (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535101789 , 9789535152231
    Language: English
    Pages: 1 Online-Ressource (158 p.)
    Keywords: Medical genetics
    Abstract: Recent Trends in Cytogenetic Studies - Methodologies and Applications deals with recent trends in cytogenetics with minute details of methodologies that can be adopted in clinical laboratories. The chapters deal with basic methods of primary cultures, cell lines and their applications; microtechnologies and automations; array CGH for the diagnosis of fetal conditions; approaches to acute lymphoblastic and myeloblastic leukemias in patients and survivors of atomic bomb exposure; use of digital image technology and using chromosomes as tools to discover biodiversity. While concentrating on the advanced methodologies in cytogenetic studies and their applications, authors have pointed out the need to develop cytogenetic labs with modern tools to facilitate precise and effective diagnosis to benefit the patient population
    Note: English
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  • 24
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    Congenital Anomalies : Case Studies and Mechanisms (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100751 , 9789535152088
    Language: English
    Pages: 1 Online-Ressource (144 p.)
    Keywords: Medical genetics
    Abstract: This book is in essence a collection of essays which are state of the art in their respective areas of knowledge. They inform the reader of all sorts of mechanistic considerations when developing understanding of issues surrounding the origins of congenital abnormalities. These chapters are written by world renown authorities in this area of science and represent a wide range of expertise from a clinician perspective, through to genetic mechanisms. Unlike some books which take a formal textual, somewhat plodding way through pathophysiology here instead we have cut through chapters in which the student , or scientist or medic is lead to understand just how complex the origins can be via examples from different parts of the body. With the erudite chapters are relevant tables and other diagrams to help clarify the text . These chapters represent a starter text for the stimulus for further knowledge of what is an increasingly important area of human health
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  • 25
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    DNA Methylation : From Genomics to Technology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535103202 , 9789535152446
    Language: English
    Pages: 1 Online-Ressource (402 p.)
    Keywords: Medical genetics
    Abstract: Epigenetics is one of the most exciting and rapidly developing areas of modern genetics with applications in many disciplines from medicine to agriculture. The most common form of epigenetic modification is DNA methylation, which plays a key role in fundamental developmental processes such as embryogenesis and also in the response of organisms to a wide range of environmental stimuli. Indeed, epigenetics is increasing regarded as one of the major mechanisms used by animals and plants to modulate their genome and its expression to adapt to a wide range of environmental factors. This book brings together a group of experts at the cutting edge of research into DNA methylation and highlights recent advances in methodology and knowledge of underlying mechanisms of this most important of genetic processes. The reader will gain an understanding of the impact, significance and recent advances within the field of epigenetics with a focus on DNA methylation
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  • 26
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    Osteogenesis (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100300 , 9789535168096
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Medical genetics
    Abstract: This book provides an in-depth overview of current knowledge about Osteogenesis, including molecular mechanisms, transcriptional regulators, scaffolds, cell biology, mechanical stimuli, vascularization and osteogenesis related diseases. Hopefully, the publication of this book will help researchers in this field to decide where to focus their future efforts, and provide an overview for surgeons and clinicians who wish to be directed in the developments related to this fascinating subject
    Note: English
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  • 27
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    Spinocerebellar Ataxia (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535105428 , 9789535169772
    Language: English
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medical genetics
    Abstract: The purpose of this book has been to depict as many biochemical, genetic and molecular advances as possible, in the vast field of the spinocerebellar ataxias
    Note: English
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