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  • Online-Ressource  (5)
  • 2015-2019  (5)
  • Antoine Toubert  (3)
  • Akio Adachi  (2)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (5)
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  • Online-Ressource  (5)
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  • 2015-2019  (5)
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  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (5)
  • 1
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889454648
    Sprache: Englisch
    Seiten: 1 Online-Ressource (407 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Recognition and killing o ...
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISBN: 9782889456635
    Sprache: Englisch
    Seiten: 1 Online-Ressource (407 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Recognition and killing o ...
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889453481
    Sprache: Englisch
    Seiten: 1 Online-Ressource (419 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Viruses are widely present in nature, and numerous viral species with a variety of unique characteristics have been identified so far. Even now, new emerging or re-emerging viruses are being found or re-found as novel viral classes or as quasi-species. Indeed, viruses are everywhere. Of note, viruses are pivotal as targets and tools of basic and applied sciences. On one hand, portions of the viruses are infectious for animals including humans, and cause various diseases in infected hosts by distinct mechanisms and at a different level of severity. While many of viruses are known to co-exist quietly with their hosts, pathogenic viruses certainly affect and threaten our society as well as individuals to provoke serious medical or economic attention. We should act against certain dreadful and highly infectious viruses as a global problem. Animal RNA viruses can readily mutate to adapt themselves in their hostile environments for their survival. Resultant viruses may sometimes show essentially altered phenotypes from the original parental strains. This fundamental and general property of animal RNA viruses represents major extensive issues of scientific, medical, and/or economic importance. In this Research Topic, we have focused on the high mutability of animal RNA viruses, and selected relevant articles on animal viruses of broad-ranges such as primate lentiviruses, influenza viruses, paramyxoviruses, flaviviruses, rabies virus, norovirus, picornaviruses, and picobirnavirus. Each article has taken up intriguing aspects of the subject viruses. We are sure that readers acquire important information on virus mutation, adaptation, diversification, and evolution, and hope that researchers in the field related to virology gain some solid hints from the reported articles for further virological and /or medical studies. Finally, we thank all the contributing researchers in this Research Topic, entitled “Highly Mutable Animal RNA Viruses: Adaptation and Evolution”, for their elegant and interesting works
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194568
    Sprache: Englisch
    Seiten: 1 Online-Ressource (173 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Understanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures against viruses. To fight against a wide variety of viruses, basic studies with specific and/ or common approaches are required. This Research Topic collects articles that describe studies on numerous virus species at various stages toward animal experiments: (i) description/evaluation/ new challenges of animal model studies; (ii) experimental material/methods for animal model studies; (iii) observations for upcoming animal model studies. Numbers of DNA and RNA viruses such as HHV-6, HPV, Ebola virus, HCV, dengue virus, HTLV-1, HIV-1, SIV, and measles virus are covered by this special issue consisting of original research, methods, review, mini-review, and opinion articles. All readers would understand, we believe and hope, that animal model studies are critical for current virology as always
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    ISBN: 9782889194919
    Sprache: Englisch
    Seiten: 1 Online-Ressource (86 p.)
    Serie: Frontiers Research Topics
    Kurzfassung: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients
    Anmerkung: English
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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