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  • Online Resource  (92)
  • 2010-2014  (92)
  • 1940-1944
  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (92)
  • Oncology  (92)
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  • Online Resource  (92)
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  • 1
    Online Resource
    Online Resource
    Pancreatic Cancer : Insights into Molecular Mechanisms and Novel Approaches to Early Detection and Treatment (2014)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535113751 , 9789535172055
    Language: English
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Oncology
    Abstract: This book provides the reader with an update on recent findings related to the molecular basis for the development and progression of pancreatic cancer. This book also informs the reader about the link between obesity and pancreatic cancer, and how a well-known and widely used anti-diabetic drug may also be potentially useful for the treatment of pancreatic cancer. Moreover, this book provides insight into novel approaches for improved earlier detection of pancreatic cancer
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 2
    Online Resource
    Online Resource
    Tumors of the Central Nervous System : Primary and Secondary (2014)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535115762 , 9789535172116
    Language: English
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Oncology
    Abstract: A novel concept that is reviewed and discussed in several chapters in the book alludes to the transport of drugs bound to red blood cells into the highly vascular CNS tumors - both primary and metastatic. Such a transport mechanism is unique and of significant therapeutic potential. It is hopeful that the novel information presented in this book will result in new approaches to the treatment CNS tumors
    Note: English
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  • 3
    Online Resource
    Online Resource
    Multiple Myeloma : A Quick Reflection on the Fast Progress (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110835 , 9789535171270
    Language: English
    Pages: 1 Online-Ressource (336 p.)
    Keywords: Oncology
    Abstract: This book does not provide a comprehensive overview of Multiple Myeloma but a collection of chapters with in-depth information of distinct hot topics in the diagnostic, research and therapeutic fields. The dynamics of testing new drugs for multiple myeloma treatment in clinical trials is breathtaking. Scientific discoveries have uncovered complicated pathogenesis of multiple myeloma; complicated reactions to treatment lead to the creation of super cocktails. Curability of multiple myeloma is a question that is being discussed by the entire professional myeloma world. Improvement of prognosis is a fact which is most important from a patient's perspective. We believe that this book could be of interest to medical professionals specializing in hematooncology, researchers, as well as many others
    Note: English
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    MPI Ethno. Forsch.
  • 4
    Online Resource
    Online Resource
    Clinical Epidemiology of Acute Lymphoblastic Leukemia : From the Molecules to the Clinic (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109907 , 9789535171294
    Language: English
    Pages: 1 Online-Ressource (344 p.)
    Keywords: Oncology
    Abstract: This book describes different perspectives of childhood acute lymphoblastic leukemia. The approach includes aspects of molecular epidemiology, particularly molecular features that influence the genesis and prognosis of the disease. Some aspects of the prognosis of lymphoblastic leukemias are very detailed, highlighting the use of molecular biology in the early identification of complications that may occur in diseased patients. The authors of the present book conform a Mexican group who identifies the causes of leukemia, and they summarize their experience in research, results and proposals for future studies. A causal model is included in which the authors hypothesized the origin of acute lymphoblastic leukemias, particularly in children. This hypothesis can be useful to better understand other cancers during childhood. This book will help the reader to identify different molecular aspects involved in leukemia, and its relation to the development and evolution of the disease
    Note: English
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  • 5
    Online Resource
    Online Resource
    Apoptosis (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111337 , 9789535153719
    Language: English
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Oncology
    Abstract: The book "Apoptosis", published by InTech and edited by Dr. Justine Rudner, of the Department of Radiation Oncology, University Hospital of Tuebingen, Germany, is comprised of 8 Open Access chapters, covering a wide range of Apoptosis-related scientific research
    Note: English
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  • 6
    Online Resource
    Online Resource
    Highlights in Skin Cancer (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110736 , 9789535171324
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Oncology
    Abstract: Highlights in Skincancer is a companion handbook published expressly for all the practitionners who are interested in skin cancers: medical oncologists and dermatologists but also residents, general practitionners, surgeons, plastic surgeons. The book is designed to teach new aspects of skincancers in the context of practical clinical settings. Each topic is an expert view of a specific skincancer field. Highlights in Skincancer provides information on a wide range of skincancer topics with emphasis on the emergence of new diagnostic approaches, therapeutic perspectives, and a better insight into the biology of the skin tumours. No doubt that the Highlights in Skincancer will be considered as a real tool throughout a medical career
    Note: English
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  • 7
    Online Resource
    Online Resource
    Hepatocellular Carcinoma : Future Outlook (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535112020 , 9789535171836
    Language: English
    Pages: 1 Online-Ressource (332 p.)
    Keywords: Oncology
    Abstract: Hepatocellular carcinoma (HCC) develops as a consequence of underlying chronic liver disease, most commonly cirrhosis. Therefore, HCC management draws on the expertise of a range of medical specialists. Many components of current novel therapeutic modalities for HCC are discussed in the current version of the book within the framework of a multidisciplinary approach with special emphasis on emerging treatment approaches and research strategies. This book is the essential clinical guide for oncologists, hepatologists, surgeons, and all physicians and researchers involved in the care of patients with HCC. I would like to thank the authors for their significant efforts in bringing this edition to life. This book is a tribute to their continued dedication to improving HCC outcome
    Note: English
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  • 8
    Online Resource
    Online Resource
    Leukemia (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111276 , 9789535171508
    Language: English
    Pages: 1 Online-Ressource (254 p.)
    Keywords: Oncology
    Abstract: Leukemias are a group of heterogeneous neoplastic disorders, that differ significantly in terms of morhological, immunophenotypic, cytogenetic and molecular features of malignant cells. These specific features reflect the differences in the spectrum of underlying biological alterations involved in malignant transformation, and/or variations in the level of hematopoietic stem cells hierarchy where the transforming events occur. The continuous and rather extensive influx of new information regarding the pathogenesis and treatment of leukemias requires a frequent updating of this topic. The primary objective of this book is to provide the specialists involved in the diagnosis and management of acute and chronic leukemias with a comprehensive and concise information on some important theoretical and practical issues of the biology and clinical presentation, the diagnosis, treatment and follow up of patients with leukemias
    Note: English
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  • 9
    Online Resource
    Online Resource
    Cancer Treatment : Conventional and Innovative Approaches (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110989 , 9789535171409
    Language: English
    Pages: 1 Online-Ressource (630 p.)
    Keywords: Oncology
    Abstract: Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition
    Note: English
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  • 10
    Online Resource
    Online Resource
    Renal Tumor (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109815 , 9789535170914
    Language: English
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Oncology
    Abstract: Summarizing a decade of scientific advance and therapeutic innovation, Renal Tumor offers all physicians treating kidney cancer, as well as researchers, updated information concerning the epidemiology, biology, and treatment of renal cell carcinoma. Contributors to this book are from all over the world and are experts in their individual fields. They have provided reviews about current knowledge in the management of both localized and metastatic renal cell carcinoma, as well as the latest developments in molecular genetics, imaging, and immune dysfunction associated with the diseases. Further special attention is paid to the biology of selected target molecules and various agents that inhibit these targets, including full chapters devoted to pharmaceutical drugs that selectively inhibit receptor tyrosine kinases, such as sunitinib and axitinib. Readers such as urological physicians, researchers, and kidney cancer patients are potential beneficiaries of this book
    Note: English
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  • 11
    Online Resource
    Online Resource
    Carcinogenesis (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109457 , 9789535170754
    Language: English
    Pages: 1 Online-Ressource (330 p.)
    Keywords: Oncology
    Abstract: Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment. Animal models are particularly useful for evaluating therapeutic or chemopreventive agents and examples are presented. Finally, natural products that ether prevent or treat cancer are described. Together these topics will provide the reader with examples of the latest cutting edge research and discoveries, with the goal of stimulating further advances
    Note: English
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  • 12
    Online Resource
    Online Resource
    Oncogenomics and Cancer Proteomics : Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110415 , 9789535171119
    Language: English
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Oncology
    Abstract: Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research
    Note: English
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  • 13
    Online Resource
    Online Resource
    Neoadjuvant Chemotherapy : Increasing Relevance in Cancer Management (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111399 , 9789535171546
    Language: English
    Pages: 1 Online-Ressource (114 p.)
    Keywords: Oncology
    Abstract: In the chapters of this excellent text, the authors have described advances in the neoadjuvant chemotherapeutic management of a number of tumor types. Based on the extensive experience with this management concept in breast cancer, several chapters are devoted to this important topic (Section 1). Section 2 deals with the administration of neoadjuvant chemotherapy in non-breast malignancies. Those who read and study the content of the chapters in this book will come away with a far greater understanding of the rationale supporting neoadjuvant chemotherapy, the existing evidence-based data regarding its use, limitations of the approach, and required future investigative efforts to learn how to optimize the benefits of this innovative management concept
    Note: English
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  • 14
    Online Resource
    Online Resource
    Human Papillomavirus and Related Diseases : From Bench to Bedside - A Diagnostic and Preventive Perspective (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110729 , 9789535171379
    Language: English
    Pages: 1 Online-Ressource (336 p.)
    Keywords: Oncology
    Abstract: Cervical cancer is the second most prevalent cancer among women worldwide, and infection with Human Papilloma Virus (HPV) has been identified as the causal agent for this condition. The natural history of cervical cancer is characterized by slow disease progression, rendering the condition in essence preventable and even treatable when diagnosed in early stages. Pap smear and the recently introduced prophylactic vaccines are the most prominent prevention options, but despite the availability of these primary and secondary screening tools, the global burden of disease is unfortunately still very high This book will focus on the clinical and diagnostic aspects of HPV and related disease, highlighting the latest developments in this field
    Note: English
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  • 15
    Online Resource
    Online Resource
    Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109891 , 9789535170990
    Language: English
    Pages: 1 Online-Ressource (650 p.)
    Keywords: Oncology
    Abstract: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided
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  • 16
    Online Resource
    Online Resource
    Trends in Cell Signaling Pathways in Neuronal Fate Decision (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110590 , 9789535171195
    Language: English
    Pages: 1 Online-Ressource (368 p.)
    Keywords: Oncology
    Abstract: During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions
    Note: English
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  • 17
    Online Resource
    Online Resource
    Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110583 , 9789535171232
    Language: English
    Pages: 1 Online-Ressource (654 p.)
    Keywords: Oncology
    Abstract: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided
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  • 18
    Online Resource
    Online Resource
    Melanoma : From Early Detection to Treatment (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109617 , 9789535170761
    Language: English
    Pages: 1 Online-Ressource (732 p.)
    Keywords: Oncology
    Abstract: The Book "Melanoma - From Early Detection To Treatment" is aiming to present data and knowledge from most experienced experts in the field. The book covers main topics from the fundamental aspects to multiple approaches in the disease treatment as well as related features. It offers a global view concerning one of the most frequent types of cancer to which a substantial high proportion of people worldwide is confronted at some time point in life
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  • 19
    Online Resource
    Online Resource
    Frontiers in Radiation Oncology (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111634 , 9789535171706
    Language: English
    Pages: 1 Online-Ressource (228 p.)
    Keywords: Oncology
    Abstract: The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research
    Note: English
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  • 20
    Online Resource
    Online Resource
    Recent Advances in the Biology, Therapy and Management of Melanoma (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109761 , 9789535170860
    Language: English
    Pages: 1 Online-Ressource (386 p.)
    Keywords: Oncology
    Abstract: The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure
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  • 21
    Online Resource
    Online Resource
    Liver Tumors : Epidemiology, Diagnosis, Prevention and Treatment (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535110705 , 9789535171256
    Language: English
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Oncology
    Abstract: The prognosis for individuals with liver cancer is frequently poor. Cancers include those which have metastasized to the liver from elsewhere, reflecting advanced stage disease where cure is rarely possible. Similarly, primary liver cancer frequently complicates chronic liver disease, which further limits therapeutic options. Despite these dismal facts, there are signs that change is imminent. Not only have imaging modalities and surgical techniques improved, but preventive strategies and medical therapies show promise. The topic of liver tumors is comprehensively reviewed in this book, with a focus on recent developments relevant to both researchers and clinicians
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  • 22
    Online Resource
    Online Resource
    T-Cell Leukemia : Characteristics, Treatment and Prevention (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109969 , 9789535170976
    Language: English
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Oncology
    Abstract: T-cell leukemia is relatively rare malignancy of thymocytes. There are around 20 entities and variants of this disease. Each of them has different characteristics, including pathogenesis, epidemiology, diagnosis, therapeutic approaches, and prognosis. Although T-cell leukemia is relatively rare malignancy, many types of T-cell leukemias still have a very poor prognosis due to rapid progression. Therefore, the development of novel therapeutic and preventive strategies is necessary to improve prognosis. The purpose of this book is to provide a comprehensive overview of the disease from the basics of pathogenesis, epidemiology, morphology, and immunological features. This book also highlights the most recent achievements from basic and clinical researches including molecular mechanisms and novel therapies of T-cell leukemia
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  • 23
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    Online Resource
    Advances in Prostate Cancer (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535109327 , 9789535170648
    Language: English
    Pages: 1 Online-Ressource (704 p.)
    Keywords: Oncology
    Abstract: Prostate cancer is one of the most common types of cancer in men and its treatment was constricted to surgery for confined state and androgen ablation for advanced disease until new options have become available. The present book covers a broad range of novel aspects of prostate cancer diagnosis, treatment and patient care, as well as new research on relevant cell biology. In detail, this special volume focusses on supportive modalities for prostate cancer patients, appropriate selection of novel therapeutic regimens, including inhibitors of steroidal synthesis, cytotoxic agents, as well as intermittent androgen suppression and the roles of prostate cancer stem cells and inflammatory processes
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  • 24
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    Advances in the Scientific Evaluation of Bladder Cancer and Molecular Basis for Diagnosis and Treatment (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535111429 , 9789535171539
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Oncology
    Abstract: Bladder cancer is the sixth most common cancer in the world affecting more than 300,000 men and women worldwide. This book summarizes the vast breadth of current understanding of the molecular and genetic processes involved in carcinogenesis of the bladder, carcinoma in-situ and treatment modalities of muscle invasive disease, immune-therapy and potential targets for future therapy
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  • 25
    Online Resource
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    Neuroblastoma (2013)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535111283 , 9789535171577
    Language: English
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Oncology
    Abstract: Tumors of neuroblastoma group are heterogenous and their molecular/genomic properties are closely related to the prognosis of patients: some children enjoy an excellent clinical course after biopsy/surgery alone, and others suffer from a fatal outcome even after an intensive treatment. Recent progress has also started disclosing critical significance of cross-talking between neuroblastoma cells and their microenvironment in predicting clinical behaviors of individual cases. In this book, the world distinguished investigators report clinical and biological characteristics of this disease
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  • 26
    Online Resource
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    Neuroendocrine Tumor (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106531 , 9789535170082
    Language: English
    Pages: 1 Online-Ressource (70 p.)
    Keywords: Oncology
    Abstract: While the incidence rate of neuroendocrine tumours has been increasing, the survival rate has not. Therefore, there is a great need for state-of-the-art research and new treatment protocols. The chapters in this book contribute to that debate and will be required reading for both researchers and healthcare practitioners, as it offers both overviews of the condition and specialized contributions. Topics covered include the association between chronic inflammation and gastroenteropancreatic neuroendocrine tumours, or GEP-NETs. GEP-NETs are also addressed in a chapter on their circulating markers, which can help in diagnosing this hard to detect condition. One chapter covers the role of Chromogranin A, while another addresses the diagnosis and management of neuroendocrine carcinomas in cases where the primary site is unknown
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  • 27
    Online Resource
    Online Resource
    Multiple Myeloma : An Overview (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533077680 , 9789535166368
    Language: English
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Oncology
    Abstract: Multiple myeloma is a malignant disorder characterized by the proliferation of plasma cells. Much insight has been gained into the molecular pathways that lead to myeloma and indeed much more remains to be done. The understanding of these pathways is closely linked to their therapeutic implications and is stressed upon in the initial chapters. Recently, the introduction of newer agents such as bortezomib, lenalidomide, thalidomide, liposomal doxorubicin, etc. has led to a flurry of trials aimed at testing various combinations in order to improve survival. Higher response rates observed with these agents have led to their integration into induction therapies. The role of various new therapies vis a vis transplantation has also been examined. Recent advances in the management of plasmacytomas , renal dysfunction, dentistry as well as mobilization of stem cells in the context of myeloma have also found exclusive mention. Since brevity is the soul of wit our attempt has been to present before the reader a comprehensive yet brief text on this important subject
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  • 28
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    Tumor Suppressor Genes (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533078793 , 9789535167440
    Language: English
    Pages: 1 Online-Ressource (346 p.)
    Keywords: Oncology
    Abstract: Functional evidence obtained from somatic cell fusion studies indicated that a group of genes from normal cells might replace or correct a defective function of cancer cells. Tumorigenesis that could be initiated by two mutations was established by the analysis of hereditary retinoblastoma, which led to the eventual cloning of RB1 gene. The two-hit hypothesis helped isolate many tumor suppressor genes (TSG) since then. More recently, the roles of haploinsufficiency, epigenetic control, and gene dosage effects in some TSGs, such as P53, P16 and PTEN, have been studied extensively. It is now widely recognized that deregulation of growth control is one of the major hallmarks of cancer biological capabilities, and TSGs play critical roles in many cellular activities through signaling transduction networks. This book is an excellent review of current understanding of TSGs, and indicates that the accumulated TSG knowledge has opened a new frontier for cancer therapies
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  • 29
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    Brachytherapy (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106029 , 9789535169932
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Oncology
    Abstract: Importance of brachytherapy is currently increasing in cancer therapy. In brachytherapy each treatment is best fitted by physician's' hand, and appropriate arrangement and selection of radiation sources facilitates the fitting. This book is full of essences to make a breakthrough in radiation oncology by brachytherapy. I hope this book will encourage all people related. Contents 1: problem of currently popular dosimetric method; 2: Monte Carlo dose simulation of ruthenim-106/rhodium-106 eyes applicators; 3. Progress in Californium-252 neutron brachytherapy; 4. Clinical aspect of endobronchial brachytherapy in central airway tumor obstruction; 5. Review from principle and techniques of Iodine-125 production at nuclear reactor plant to their clinical practive in prostate cancer treatment; 6. Stereotactic Brachytherapy for Brain Tumors using Iodine-125 seed; 7. A brachytherapy procedure with organ-sparing hyaluronate gel injection for safe and eradicative reirradiation
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  • 30
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    Malignant Mesothelioma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535109013 , 9789535170532
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Keywords: Oncology
    Abstract: This book brings together the knowledge of eminent experts in the field of malignant mesothelioma, a highly invasive tumor of mesothelium that is the protective lining covering several body cavities. Malignant mesothelioma shows extremely poor progression and is refractory to almost any kind of therapy putting considerable challenges in its treatment. This book covers many important aspects of malignant mesothelioma like epidemiology, immunology, molecular mechanisms and clinical options and will be useful to anybody interested in its history, pathology, and treatment
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  • 31
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    Modern Practices in Radiation Therapy (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535104278 , 9789535169406
    Language: English
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Oncology
    Abstract: Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. It is an enormous global health encumbrance, growing at an alarming pace. Global statistics show that in 2030 alone, about 21.4 million new cancer cases and 13.2 million cancer deaths are expected to occur, simply due to the growth, aging of the population, adoption of new lifestyles and behaviors. Amongst the several modes of treatment for cancer available, Radiation treatment has a major impact due to technological advancement in recent times. This book discusses the pros and cons of this treatment modality. This book "Modern Practices in Radiation Therapy" has collaged topics contributed by top notch professionals and researchers all around the world
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  • 32
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    Neuroblastoma : Present and Future (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533070162 , 9789535166382
    Language: English
    Pages: 1 Online-Ressource (378 p.)
    Keywords: Oncology
    Abstract: Neuroblastoma, once called "enigmatic", due to "unpredictable" clinical behaviors, is composed of biologically diverse tumors. Molecular/genomic properties unique to the individual tumors closely link to the clinical outcomes of patients. Establishing risk stratification models after analyzing biologic characteristics of each case has made a great success in patient management. However, the trend of improving survival rates in neuroblastoma over the last 30 years has started to level off, and currently available treatment modalities have almost reached to their maximized intensity. Furthermore, aggressive treatment causes significant long-term morbidities to the survivors. We really need to make the next step to the level of personalized medicine with more precise understanding of neuroblastoma biology. This book includes useful data and insights from the world's experts in this field. I believe this book can make an excellent contribution to all the investigators working hard and fighting for the children stricken by this disease
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  • 33
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    Esophageal Cancer : Cell and Molecular Biology, Biomarkers, Nutrition and Treatment (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535102236 , 9789535169994
    Language: English
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Oncology
    Abstract: Esophageal Cancer illustrates recent achievements and investigations in the esophageal tumorigenesis from different perspectives. Readers find mechanisms involved in esophageal tumorigenesis, cellular, molecular, genetic, epigenetics, and proteomics, their relevance as the novel biomarkers and application in esophageal cancer diagnosis and therapy. The book covers detailed effect of nutritional factors in addition to ethanol metabolic pathway in the inhibition of retinoic acid metabolism and supply. Diagnosis, classification, and treatment of esophageal cancer, application of both surgical and non surgical methods as well as follow up of the disease are described in detail. Moreover readers are endowed with especial features of esophageal cancer such as multiple early stage malignant melanoma and pulmonary edema induced by esophagectomy, the two features that received less attention elsewhere in literature
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  • 34
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    Basal Cell Carcinoma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535103097 , 9789535169055
    Language: English
    Pages: 1 Online-Ressource (136 p.)
    Keywords: Oncology
    Abstract: Basal cell carcinoma is the commonest cutaneous malignancy. The last decade has witnessed exponential research which has broadened our understanding of the pathogenesis of basal cell carcinomas. This is also important from a therapeutic point of view as targeted approach to therapy is now being increasingly experimented. Although it is impossible to condense and present all good research in one book, the authors have to be commended on presenting their research on several aspects of basal cell carcinoma in a succinct manner, which shall not only enhance our understanding of, but also hopefully via this open exchange of ideas pave ways for successful targeted therapy of the commonest human cancer
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  • 35
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    Myeloid Leukemia : Clinical Diagnosis and Treatment (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533078861 , 9789535167501
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Oncology
    Abstract: This book comprises a series of chapters from experts in the field of diagnosis and treatment of myeloid leukemias from all over the world, including America, Europe, Africa and Asia. It contains both reviews on clinical aspects of acute (AML) and chronic myeloid leukemias (CML) and original publications covering specific clinical aspects of these important diseases. Covering the specifics of myeloid leukemia epidemiology, diagnosis, risk stratification and management by authors from different parts of the world, this book will be of interest to experienced hematologists as well as physicians in training and students from all around the globe
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  • 36
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    Novel Therapeutic Concepts in Targeting Glioma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535104919 , 9789535169598
    Language: English
    Pages: 1 Online-Ressource (308 p.)
    Keywords: Oncology
    Abstract: Novel Therapeutic Concepts for Targeting Glioma offers a comprehensive collection of current information and the upcoming possibilities for designing new therapies for Glioma by an array of experts ranging from Cell Biologists to Oncologists and Neurosurgeons. A variety of topics cover therapeutic strategies based on Cell Signaling, Gene Therapy, Drug Therapy and Surgical methods providing the reader with a unique opportunity to expand and advance his knowledge of the field
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  • 37
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    Emerging Research and Treatments in Renal Cell Carcinoma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100225 , 9789535168034
    Language: English
    Pages: 1 Online-Ressource (454 p.)
    Keywords: Oncology
    Abstract: The field of renal cell cancer has undergone a significant resurgence. This book summarizes up-to-date research and innovative ideas for the future in this rapidly changing field, which encompasses medicine, surgery, radiation oncology, basic science, pathology, radiology, and supportive care. This book is aimed at the clinician or scientist who has an interest in renal cell cancer, whether they are academic or nonacademic. The book covers tumor biology, molecular biology, surgery techniques, radiation therapy, personal testimonies, and present and future treatments of the disease that are on the horizon. The goal was to produce a textbook that would act as an authoritative source for scientists and clinicians and interpret the field for trainees in surgery, medicine, radiation oncology, and pathology
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  • 38
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    Squamous Cell Carcinoma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100249 , 9789535168058
    Language: English
    Pages: 1 Online-Ressource (316 p.)
    Keywords: Oncology
    Abstract: This book points to some new areas for investigation on squamous cell carcinoma (SCC). Firstly, the features and management of some specific SCC is discussed to give the readers the general principles in dealing with these uncommon and sophisticated conditions. Some new concepts in adjuvant therapy including neoadjuvant therapy and gold nanoparticle-based photo dynamic therapy are introduced. Secondly, a detailed discussion of molecular aspects of tumor invasion and progression in SCC is provided with the emphasis on the roles of some important factors. The role of tumor microenvironment in head and neck SCC is specifically discussed. Thirdly, the roles of cancer stem cells (CSC) in cancer therapy of SCC are described. Molecular mechanisms involving therapeutic resistance and new therapeutic strategies targeting CSC are discussed in detail. Finally, other aspects concerning SCC are included, which involve the assessment, genetic manipulation and its possible clinical implications for the treatment of SCC
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  • 39
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    Liver Tumors (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100362 , 9789535168119
    Language: English
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Oncology
    Abstract: This book is oriented towards clinicians and scientists in the field of the management of patients with liver tumors. As many unresolved problems regarding primary and metastatic liver cancer still await investigation, I hope this book can serve as a tiny step on a long way that we need to run on the battlefield of liver tumors
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  • 40
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    Pancreatic Cancer : Clinical Management (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535103943 , 9789535169291
    Language: English
    Pages: 1 Online-Ressource (326 p.)
    Keywords: Oncology
    Abstract: This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression
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  • 41
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    Bladder Cancer : From Basic Science to Robotic Surgery (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533078397 , 9789535167129
    Language: English
    Pages: 1 Online-Ressource (472 p.)
    Keywords: Oncology
    Abstract: This book is an invaluable source of knowledge on bladder cancer biology, epidemiology, biomarkers, prognostic factors, and clinical presentation and diagnosis. It is also rich with plenty of up-to-date information, in a well-organized and easy to use format, focusing on the treatment of bladder cancer including surgery, chemotherapy, radiation therapy, immunotherapy, and vaccine therapy. These chapters, written by the experts in their fields, include many interesting, demonstrative and colorful pictures, figures, illustrations and tables. Due to its practicality, this book is recommended reading to anyone interested in bladder cancer
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  • 42
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    Oral Cancer (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535102281 , 9789535168737
    Language: English
    Pages: 1 Online-Ressource (402 p.)
    Keywords: Oncology
    Abstract: Oral cancer is a significant public health challenge globally. Although the oral cavity is easily accessible, early diagnosis remains slow compared to the enhanced detection of cancers of the breast, colon, prostate, and melanoma. As a result, the mortality rate from oral cancer for the past four decades has remained high at over 50% in spite of advances in treatment modalities. This contrasts with considerable decrease in mortality rates for cancers of the breast, colon, prostate, and melanoma during the same period. This book attempts to provide a reference-friendly update on the etiologic/risk factors, current clinical diagnostic tools, management philosophies, molecular biomarkers, and progression indicators of oral cancer
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  • 43
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    Advancements in Tumor Immunotherapy and Cancer Vaccines (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533079981 , 9789535167884
    Language: English
    Pages: 1 Online-Ressource (230 p.)
    Keywords: Oncology
    Abstract: Harnessing the potential of the human body's own immune system to attack malignant tumor cells has been the goal of many scientific investigators in recent years, with advances in cancer biology and immunology enabling cancer immunotherapy to become a reality. World-class bench and clinical researchers have joined forces to collaborate and review current developments and trends in cancer immunology for the purposes of this book, and the result is a promising review of contemporary clinical treatments. In each chapter the authors present the scientific basis behind such therapeutic approaches, including cancer vaccines with special focus on prostate cancer, melanoma and novel approaches utilizing both innate and adaptive immune responses
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  • 44
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    Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533078670 , 9789535167358
    Language: English
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Oncology
    Abstract: This book is a comprehensive treatise of the potential risk factors associated with NPC development, the tools employed in the diagnosis and detection of NPC, the concepts behind NPC patients who develop neuro-endocrine abnormalities and ear-related complications after radiotherapy and chemotherapy, the molecular mechanisms leading to NPC carcinogenesis, and the potential therapeutic molecular targets for NPC
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  • 45
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    Carcinogen (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535106586 , 9789535170105
    Language: English
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Oncology
    Abstract: During the last decades, cancer diseases have increased all over the world. The low quality of food and strong pollution of environment are the main prerequisites for carcinogenesis. The main problem for scientists is to find strategy for prevention of cancer diseases. Therefore, the information about the models for studying carcinogenesis and mutagens which appear during cooking, environmental pollutants, and tests for specific detection of carcinogens is particularly important. The book "Carcinogen" is intended for biologists, researchers, students in medical sciences and professionals interested in associated areas
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  • 46
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    Tumor Microenvironment and Myelomonocytic Cells (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535104391 , 9789535169468
    Language: English
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Oncology
    Abstract: Tumor microenvironment represents an extremely dynamic niche shaped by the interplay of different cell types (e.g. tumor cells, stromal cells), their soluble products (e.g.cytokines, chemokines and growth factors) and varied physico-chemical conditions (e.g low oxygen concentration or hypoxia). Recent studies have identified myelomonocytic cells as key players in regulating the tumor microenvironment and hence, tumor progression in a variety of cancers. In view of these findings, the present book attemps to provide a comprehensive account of the diversity of tumor microenvironment across different cancers and how myelomonocytic cells have taken the center-stage in regulating this niche to direct cancer progression. A better understanding of the myelomonocytic cells and the mechanisms by which they regulate cancer progression will open new vistas in cancer therapeutics
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  • 47
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    Hepatocellular Carcinoma : Clinical Research (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535101123 , 9789535168348
    Language: English
    Pages: 1 Online-Ressource (342 p.)
    Keywords: Oncology
    Abstract: This book covers the clinical aspects of hepatocellular carcinoma. This book is a compendium of papers written by experts from different parts of the world to present the most up-to-date knowledge on the clinical aspects of hepatocellular carcinoma. This book is divided into three sections: (I) Diagnosis / Differential Diagnosis; (II) Surgical Treatment; (III) Non-surgical Treatment. There are 19 chapters covering topics from novel diagnostic methods to hepatic lesions mimicking hepatocellular carcinoma, from laparoscopic liver resection to major hepatectomy without allogeneic blood transfusion, from molecular targeted therapy to transarterial radioembolization, and from local ablative therapy to regional therapy. This volume is an important contribution to the clinical management of patients with hepatocellular carcinoma. The intended readers of this book are clinicians who are interested in hepatocellular carcinoma, including hepatologists, liver surgeons, interventional and diagnostic radiologists, pathologists and epidemiologists. General surgeons, general physicians, trainees, hospital administrators, and instruments and drug manufacturers will also find this book useful as a reference
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  • 48
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    Cytokeratins : Tools in Oncology (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535100478 , 9789535168188
    Language: English
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Oncology
    Abstract: The first chapters of the volume "Cytokeratins - Tools in Oncology" discuss multiple functions of cytokeratins in organization of the intermediary filaments in normal intestine and liver as well as microfold L cells and the usability of cytokeratins 7, 8 and 20 in tumor diagnosis in detail. Epithelial to mesenchymal transition as a mechanism important in pathogenesis is touched in another chapter, followed by several articles dealing with the role of cytokeratins for detection of disseminated tumor cells and as response markers during chemotherapy. This book is therefore destined to all cancer researchers and therapists who want to understand the diagnostic application of cytokeratins in histology and, especially, the use of anti-cytokeratin antibodies to identify viable residual tumor cells accounting for a higher risk of tumor recurrence or cancer cells responding to chemotherapy, respectively
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  • 49
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    Advances in Cancer Management (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533078700 , 9789535167389
    Language: English
    Pages: 1 Online-Ressource (290 p.)
    Keywords: Oncology
    Abstract: Cancer is now the most common cause of death in the world. However, because of early diagnosis, better treatment, and advanced life expectancy, many cancer patients frequently live a long, happy, and healthy life after the diagnosis- and often live as long as patients who eventually do not die because of cancer. This book presents newer advances in diagnosis and treatment of specific cancers, an evidence-based and realistic approach to the selection of cancer treatment, and cutting-edge laboratory developments such as the use of the MALDI technique and computational methods that can be used to detect newer protein biomarkers of cancers in diagnosis and to evaluate the success of treatment
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  • 50
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    Pancreatic Cancer : Molecular Mechanism and Targets (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535104100 , 9789535169352
    Language: English
    Pages: 1 Online-Ressource (446 p.)
    Keywords: Oncology
    Abstract: This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-flourouracil
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    Updates in the Understanding and Management of Thyroid Cancer (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535102991 , 9789535169017
    Language: English
    Pages: 1 Online-Ressource (314 p.)
    Keywords: Oncology
    Abstract: Thyroid cancer can be either common or rare, and takes several forms in multiple populations, such as children and adolescents. The chapters in this book, which provide state-of-the-art knowledge in understanding and treating the condition, are therefore welcome. Our understanding of thyroid cancer is advanced by several chapters on its incidence in a Spanish population, the functionality of p53 and the use of microarray technology in research. Diagnostic issues include the roles of glycosylation and glycoproteins, and use of a γ-camera to evaluate the in vivo biodistributions and internal medical dosimetries of Iodine-131. The majority of chapters address the range of possible treatment protocols, such as IGF signalling, surgical management, sentinel lymph node biopsy, radioiodine treatment and differentiation therapy
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  • 52
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    Hematology : Science and Practice (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101741 , 9789535168584
    Language: English
    Pages: 1 Online-Ressource (614 p.)
    Keywords: Oncology
    Abstract: Hematology encompasses the physiology and pathology of blood and of the blood-forming organs. In common with other areas of medicine, the pace of change in hematology has been breathtaking over recent years. There are now many treatment options available to the modern hematologist and, happily, a greatly improved outlook for the vast majority of patients with blood disorders and malignancies. Improvements in the clinic reflect, and in many respects are driven by, advances in our scientific understanding of hematological processes under both normal and disease conditions. Hematology - Science and Practice consists of a selection of essays which aim to inform both specialist and non-specialist readers about some of the latest advances in hematology, in both laboratory and clinic
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  • 53
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    Cancer of the Uterine Endometrium : Advances and Controversies (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535101420 , 9789535168447
    Language: English
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Oncology
    Abstract: The book Cancer of the Uterine Endometrium - Advances and Controversies brings together an international collaboration of authors who share their contributions for the management of endometrial carcinoma. The scope of the text is not basic, but rather aims to provide a comprehensive and updated source of advances in the diagnosis and therapeutic strategies in this field of gynecologic cancer. Each section in the book attempts to provide the most relevant evidence-based information in the biology and genetics, modern imaging, surgery and staging, and therapies for endometrial cancer. It is hoped that future editions will bring additional authors to contribute to this endeavor. To this end, it is our patients who will benefit from this work
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  • 54
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    Mesotheliomas : Synonyms and Definition, Epidemiology, Etiology, Pathogenesis, Cyto-Histopathological Features, Clinic, Diagnosis, Treatment, Prognosis (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533078458 , 9789535167150
    Language: English
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Oncology
    Abstract: Mesotheliomas are mysterious mesothelial tumors in that they are relatively rare, difficult to diagnose, with a large number of synonyms, and the etiology and pathogenesis of the disease are still not fully disclosed. This problem attracts the attention of various specialists in the field of medicine and biology every year. In recent years there has been a significant increase of mesothelioma morbidity in most of the countries, due to the further industrialization of society. In this regard, this book has been published with the participation of an international group of experts with rich experience from around the world . The book consists of 14 chapters containing the most advanced achievements of all aspects of the various types of mesotheliomas, both in humans and domestic animals, at a high methodological level. This book is intended for biologists and all health care workers, mostly oncologists of different profiles, as well as students of medical educational institutions engaged or even just interested in the problems of mesotheliomas
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    Germ Cell Tumor (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535104568 , 9789535169482
    Language: English
    Pages: 1 Online-Ressource (162 p.)
    Keywords: Oncology
    Abstract: The book aims to provide an overview of current knowledge regarding germ cell tumors. It deals with the clinical presentations, treatment modalities, the biology and genetics of germ cell tumors in children and adults. Most chapters are focused on testicular germ cell tumors whose incidence has been increasing in young males. Included are reviews on the pathogenesis, risk factors, diagnosis and treatment regimens applied to precursor, pre-invasive lesions as well as to seminomatous and non-seminomatous germ cell tumors of the testes. In addition, a review is included on the diagnosis and current management options for intracranial germ cell tumors in children. Authors have also contributed articles on the genetics and epigenetics of germ cell tumor development in humans and in the mouse model system. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of germ cell cancers
    Note: English
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  • 56
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    Hepatocellular Carcinoma : Basic Research (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100232 , 9789535168041
    Language: English
    Pages: 1 Online-Ressource (414 p.)
    Keywords: Oncology
    Abstract: Hepatocellular Carcinoma represents a leading cause of cancer death and a major health problem in developing countries where hepatitis B infection is prevalent. It has also become increasingly important with the increase in hepatitis C infection in developed countries. Knowledge of hepatocellular carcinoma has progressed rapidly. This book is a compendium of papers written by experts to present the most up-to-date knowledge on hepatocellular carcinoma. This book deals mainly with the basic research aspect of hepatocellular carcinoma. The book is divided into three sections: (I) Biomarkers / Therapeutic Target; (II) Carcinogenesis / Invasion / Metastasis; and (III) Detection / Prevention / Prevalence. There are 18 chapters in this book. This book is an important contribution to the basic research of hepatocellular carcinoma. The intended readers of this book are scientists and clinicians who are interested in research on hepatocellular carcinoma. Epidemiologists, pathologists, hospital administrators and drug manufacturers will also find this book useful
    Note: English
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  • 57
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    Colorectal Cancer Biology : From Genes to Tumor (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100621 , 9789535168218
    Language: English
    Pages: 1 Online-Ressource (460 p.)
    Keywords: Oncology
    Abstract: Colorectal cancer is a common disease, affecting millions worldwide and represents a global health problem. Effective therapeutic solutions and control measures for the disease will come from the collective research efforts of clinicians and scientists worldwide. This book presents the current status of the strides being made to understand the fundamental scientific basis of colorectal cancer. It provides contributions from scientists, clinicians and investigators from 20 different countries. The four sections of this volume examine the evidence and data in relation to genes and various polymorphisms, tumor microenvironment and infections associated with colorectal cancer. An increasingly better appreciation of the complex inter-connected basic biology of colorectal cancer will translate into effective measures for management and treatment of the disease. Research scientists and investigators as well as clinicians searching for a good understanding of the disease will find this book useful
    Note: English
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  • 58
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    Neoadjuvant Chemotherapy : Current Applications in Clinical Practice (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533079943 , 9789535167860
    Language: English
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Oncology
    Abstract: The most significant advances in cancer therapy in recent years have involved the development of systemic therapeutics. With improvements in response rates in solid tumors, opportunities have arisen to enhance the effectiveness of surgery. Administration of systemic therapy prior to surgery - neoadjuvant chemotherapy - represents one approach by which clinicians have successfully reduced the extent of surgery and, in some instances, positively impacted on clinical outcomes. This collection of works by expert clinicians from a variety of disciplines represents an exploration of the current knowledge of the role of neoadjuvant chemotherapy in diverse tumor types
    Note: English
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  • 59
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    Cancer Management (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106500 , 9789535170099
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Keywords: Oncology
    Abstract: Cancer remains a major clinical challenge as a cause of death due to its frequent poor prognosis and limited treatment options in many cases. Cancer management book addresses various cancer management related topics including new approaches for early cancer detection and novel anti-cancer therapeutic strategies. This book is a collection of studies and reviews written by experts from different parts of the world to present the most up-to-date knowledge on cancer management
    Note: English
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  • 60
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    Tumor Angiogenesis (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535100096 , 9789535167952
    Language: English
    Pages: 1 Online-Ressource (308 p.)
    Keywords: Oncology
    Abstract: Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer
    Note: English
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  • 61
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    Pathophysiology and Clinical Aspects of Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535106166 , 9789535169987
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Oncology
    Abstract: Venous Thromboembolism remains a major health challenge in many countries because of the morbidity and mortality it inflicts, mainly in hospitalized patients. This book, with contributions from distinguished experts in the field, depicts some hot aspects on aetilogics of VTE, the disease burden in neonates, renal disease and cancer patients as well as issues relevant to prophylaxis and the concept of VTE as patient injury content
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  • 62
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    Intraepithelial Neoplasia (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533079875 , 9789535167815
    Language: English
    Pages: 1 Online-Ressource (466 p.)
    Keywords: Oncology
    Abstract: The book "Intraepithelial neoplasia" is till date the most comprehensive book dedicated entirely to preinvasive lesions of the human body. Created and published with an aim of helping clinicians to not only diagnose but also understand the etiopathogenesis of the precursor lesions, the book also attempts to identify its molecular and genetic mechanisms. All of the chapters contain a considerable amount of new information, with an updated bibliographical list as well as the latest WHO classification of intraepithelial lesions that has been included wherever needed. The text has been updated according to the latest technical advances.This book can be described as concise, informative, logical and useful at all levels discussing thoroughly the invaluable role of molecular diagnostics and genetic mechanisms of the intraepithelial lesions. To make the materials easily digestive, the book is illustrated with colorful images
    Note: English
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  • 63
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    Gastrointestinal Stromal Tumor (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535105800 , 9789535169871
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Keywords: Oncology
    Abstract: Almost 30 years have gone by since the postulation that GISTs derive from mesenchymal stem elements, and only 15 years have gone by since the definitive detection of origin of GISTs. Research in the last decade was more focused upon the justification of imatinib mezylate therapy in GISTs and clarification why a secondary resistance that occurred during the kinase inhibitors therapy. The era of therapy for GISTs, targeting the primary activating mutations in the KIT proto-oncogene; is being proclaimed as bringing the message of special importance to the pathologist role in multidisciplinary team that are responsible for treating patients with locally advanced or metastatic GIST. This is the first conclusive message forthcoming from this book. On the other hand, the book provides summarised and case-based knowledge on current management of gastrointestinal and extragastrointestinal stromal tumours. We hope that this book may be considered as a worthwhile timely addition to clinical science dissemination, medical education, further basic and clinical research
    Note: English
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  • 64
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    Hodgkin's Lymphoma (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535104025 , 9789535169338
    Language: English
    Pages: 1 Online-Ressource (284 p.)
    Keywords: Oncology
    Abstract: Hodgkin's Lymphoma is the book consisting of 11 chapters: Recent insights into the biology of Hodgkin's lymphoma, including historical aspects, epidemiology, pathophysiology, genetic defects, and prognostic indicators are explained in the intro chapters. After a translational chapter from tumor microenvironment to immunotherapeutic approach, treatment of early stage, advanced, and refractory Hodgkin's lymphoma are explained in the following chapters. MALT lymphoma and adverse effects of chemotherapy and radiotherapy in the affected patients are discussed in the subsequent chapters, while the final chapter is focused on survivorship in Hodgkin's lymphoma. The book is intended to present recent advances in the pathophysiology of Hodgkin's lymphoma as well as practical approach to diagnosis and management in clinical practice, which is hoped to be welcomed by the physicians, who wish to learn more about Hodgkin's lymphoma
    Note: English
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  • 65
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    Head and Neck Cancer (2012)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789535102366 , 9789535168782
    Language: English
    Pages: 1 Online-Ressource (442 p.)
    Keywords: Oncology
    Abstract: Head and Neck Cancer provides an interesting and comprehensive overview of all aspects of head and neck cancer including overviews of the disease, basic science aspects pertaining to the disease, diagnosis, treatment and outcomes for patients with this disease. The chapters written by world renowned experts cover the entire discipline of head and neck oncology and include discussions of regional disparity is, advances in basic science understanding, advances in her radiotherapy, chemotherapy and targeted agents as well as a focus on reconstruction, prostheses, and aspects of quality of life and health outcomes. The book is designed to be both practical and comprehensive for every physician treating his complex disease
    Note: English
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  • 66
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    Skin Cancers : Risk Factors, Prevention and Therapy (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533077222 , 9789535165620
    Language: English
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Oncology
    Abstract: Skin cancers are the fastest growing type of cancer in the United States and represent the most commonly diagnosed malignancy, surpassing lung, breast, colorectal and prostate cancer. In Europe, the British Isles have been the highest rates of skin cancer in children and adolescents. The overall idea of this book is to provide the reader with up to date information on the possible tools to use for prevention, diagnosis and treatment of skin cancer. Three main issues are discussed: risk factors, new diagnostic tools for prevention and strategies for prevention and treatment of skin cancer using natural compounds or nano-particle drug delivery and photodynamic therapy
    Note: English
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  • 67
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    Soft Tissue Tumors (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533078625 , 9789535167303
    Language: English
    Pages: 1 Online-Ressource (284 p.)
    Keywords: Oncology
    Abstract: Soft tissue tumors include a heterogeneous group of diagnostic entities, most of them benign in nature and behavior. Malignant entities, soft tissue sarcomas, are rare tumors that account for1% of all malignancies. These are predominantly tumors of adults, but 15% arise in children and adolescents. The wide biological diversity of soft tissue tumors, combined with their high incidence and potential morbidity and mortality represent challenges to contemporary researches, both at the level of basic and clinical science. Determining whether a soft tissue mass is benign or malignant is vital for appropriate management. This book is the result of collaboration between several authors, experts in their fields; they succeeded in translating the complexity of soft tissue tumors and the diversity in the diagnosis and management of these tumors
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  • 68
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    Current cancer treatment : novel beyond conventional approaches (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen | Rijeka : IN TECH d.o.o.
    Details
    ISBN: 9789535165996
    Language: English
    Pages: 1 Online-Ressource (XIV, 810 Seiten) , Illustrationen (farbig)
    Keywords: Oncology ; Aufsatzsammlung
    Abstract: Currently there have been many armamentaria to be used in cancer treatment. This indeed indicates that the final treatment has not yet been found. It seems this will take a long period of time to achieve. Thus, cancer treatment in general still seems to need new and more effective approaches. The book "Current Cancer Treatment - Novel Beyond Conventional Approaches", consisting of 33 chapters, will help get us physicians as well as patients enlightened with new research and developments in this area. This book is a valuable contribution to this area mentioning various modalities in cancer treatment such as some rare classic treatment approaches: treatment of metastatic liver disease of colorectal origin, radiation treatment of skull and spine chordoma, changing the face of adjuvant therapy for early breast cancer; new therapeutic approaches of old techniques: laser-driven radiation therapy, laser photo-chemotherapy, new approaches targeting androgen receptor and many more emerging techniques
    Note: Literaturangaben , English
    DOI: 10.5772/897
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  • 69
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    Cancer Stem Cells : The Cutting Edge (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075808 , 9789535164449
    Language: English
    Pages: 1 Online-Ressource (632 p.)
    Keywords: Oncology
    Abstract: Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect of cancer stem cells, from theory and models to specific applications (glioma), from laboratory research on signal pathways to clinical trials of bio-therapies using a host of devices, from solutions to laboratory problems to speculation on cancers' stem cells' evolution. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis
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  • 70
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    Research on Melanoma : A Glimpse into Current Directions and Future Trends (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533072937 , 9789535164814
    Language: English
    Pages: 1 Online-Ressource (428 p.)
    Keywords: Oncology
    Abstract: The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented
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  • 71
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    Prostate Cancer : Original Scientific Reports and Case Studies (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533073422 , 9789535165811
    Language: English
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Oncology
    Abstract: This book encompasses three sections pertaining to the topics of cancer biology, diagnostic markers, and therapeutic novelties. It represents an essential resource for healthcare professionals and scientist dedicated to the field of prostate cancer research. This book is a celebration of the significant advances made within this field over the past decade, with the hopes that this is the stepping stone for the eradication of this potentially debilitating and/or fatal malignancy
    Note: English
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  • 72
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    Advances in Malignant Melanoma : Clinical and Research Perspectives (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075754 , 9789535164920
    Language: English
    Pages: 1 Online-Ressource (266 p.)
    Keywords: Oncology
    Abstract: This book titled Advances in Malignant Melanoma - Clinical and Research Perspectives represents an international effort to highlight advances in our understanding of malignant melanoma from both clinical and research perspectives. The authors for this book consist of an international group of recognized leaders in melanoma research and patient care, and they share their unique perspectives regarding melanoma epidemiology, risk factors, diagnostic and prognostic tools, phenotypes, treatment, and future research directions. The book is divide into four sections: (1) Epidemiology and Risk Factors of Melanoma, (2) Clinical Phenotypes of Melanoma, (3) Investigational Treatments for Melanoma and Pigmentary Disorders, and (4) Advances in Melanoma Translational Research. This book does not attempt to exhaustively cover all aspects of the aforementioned topics. Rather, it is a compilation of our authors' pearls and unique perspectives on the relevant advances in melanoma during the recent years
    Note: English
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  • 73
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    Brain Tumors : Current and Emerging Therapeutic Strategies (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075884 , 9789535164579
    Language: English
    Pages: 1 Online-Ressource (434 p.)
    Keywords: Oncology
    Abstract: Brain Tumors: Current and Emerging Therapeutic Strategies focuses on tumor models, the molecular mechanisms involved in the pathogenesis of this disease, and on the new diagnostic and treatment strategies utilized to stage and treat this malignancy. A special section on immunotherapy and gene therapy provides the most up-to-date information on the pre-clinical and clinical advances of this therapeutic venue. Each chapter in Brain Tumors: Current and Emerging Therapeutic Strategies is authored by international experts with extensive experience in the areas covered
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  • 74
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    T-Cell Leukemia (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533074009 , 9789535165392
    Language: English
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Oncology
    Abstract: The purpose of this book is to provide a comprehensive review of the scientific advances in T-cell malignancies and to highlight the most relevant findings that will help the reader understand both basic mechanisms of the disease and future directions that are likely to lead to novel therapies. In order to assure a thorough approach to these problems, contributors include basic scientists, translational researchers and clinicians who are experts in this field. Thus, the target audience for this book includes both basic scientists who will use this book as a review of the advances in our fundamental knowledge of the molecular mechanisms of T-cell malignancies, as well as clinicians who will use this book as a tool to understand rationales for the development of novel treatments for these diseases
    Note: English
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  • 75
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    Cancer Stem Cells : Theories and Practice (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533072258 , 9789535164265
    Language: English
    Pages: 1 Online-Ressource (474 p.)
    Keywords: Oncology
    Abstract: Cancer Stem Cells Theories and Practice does not 'boldly go where no one has gone before!' Rather, Cancer Stem Cells Theories and Practice boldly goes where the cutting edge of research theory meets the concrete challenges of clinical practice. Cancer Stem Cells Theories and Practice is firmly grounded in the latest results on cancer stem cells (CSCs) from world-class cancer research laboratories, but its twenty-two chapters also tease apart cancer's vulnerabilities and identify opportunities for early detection, targeted therapy, and reducing remission and resistance
    Note: English
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  • 76
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    Advances in the Biology, Imaging and Therapies for Glioblastoma (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533072845 , 9789535165590
    Language: English
    Pages: 1 Online-Ressource (436 p.)
    Keywords: Oncology
    Abstract: This book is intended for physicians and scientists with interest in glioblastoma biology, imaging and therapy. Select topics in DNA repair are presented here to demonstrate novel paradigms as they relate to therapeutic strategies. The book should serve as a supplementary text in courses and seminars as well as a general reference
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  • 77
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    Management of Gastric Cancer (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533073446 , 9789535164364
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Keywords: Oncology
    Abstract: Gastric cancer is the fifth most common cancer and the second most common cause of cancer death worldwide. More than 50% of the patients have advanced disease at diagnosis and in this case the disease has a poor outcome. The staging of gastric cancers is based on endoscopic ultrasound, computed tomography, magnetic resonance imaging, positron emission tomography, in addition to the laparoscopic staging. Many improvements in the surgical techniques have been seen in the last decade. Laparoscopic surgery is an emerging approach which offers important advantages: less blood loss, reduced postoperative pain, accelerated recovery, early return to normal bowel function and reduced hospital stay. D1 lymphadenectomy, with a goal of examining 15 or greater lymph nodes is a standard. D2 dissection is considered as a standard in several institutions especially in eastern Asia. Perioperative chemotherapy and adjuvant concurrent radiochemotherapy are recognized as standards treatments. Palliative chemotherapy is the mainstay treatment of advanced stages of the disease (metastatic and non-operable tumors). Despite these treatment advances, the prognosis of gastric cancer remains poor with a 5-year survival ranging from 10 to 15% in all stages combined
    Note: English
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  • 78
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    Pheochromocytoma : A New View of the Old Problem (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533078229 , 9789535167037
    Language: English
    Pages: 1 Online-Ressource (176 p.)
    Keywords: Oncology
    Abstract: The book is divided into six sections. The first three sections focus on the pathophysiology of the disease, showing anatomo- and histopathological aspects, experimental models and signaling pathways and programmed cell death related to pheochromocytoma. The fourth discusses some specific aspects of clinical presentation, with emphasis on clinical manifestations of headache and heart. The fifth section focuses on clinical diagnosis, laboratory and imaging, including differential diagnosis. Finally, the last section discusses the treatment of pheochromocytoma showing clinical cases, a case about undiagnosed pheochromocytoma complicated with multiple organ failure and other cases about catecholamine-secreting hereditary tumors. Thus, this book shows the disease "pheochromocytoma" in a different perspective from the traditional approach. Enjoy your reading
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  • 79
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    Skin Cancer Overview (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789533077468 , 9789535166139
    Language: English
    Pages: 1 Online-Ressource (228 p.)
    Keywords: Oncology
    Abstract: The book Skin Cancer Overview is divided into three sections to cover the most essential topics in skin cancer research: Etiology, Diagnosis and Treatment, and Prevention. Due to the complexity of skin cancer, this book attempts to not only provide the basic knowledge, but also present the novel trends of skin cancer research. All chapters were written by experts from around the world. It will be a good handbook for researchers with interests in skin cancer
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    Renal Cell Carcinoma (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533078441 , 9789535167143
    Language: English
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Oncology
    Abstract: Surgical and medical oncologists have been unable to decrease renal cell carcinoma mortality for uncertain reasons, although a lot of progress has been made in diagnosis and imaging, recognition of different genetic and pathological entities, management of localized disease and in the research on new drug treatments for advanced stages of the disease, potentially combined with surgery. The purpose of this book, which tackles a number of separate interesting topics, is to provide further insight into the disease and the management of early and advanced renal cell carcinoma. The volume is divided into different parts; the first part covers the characterization of renal masses and the second part covers rare distinct pathological entity. In the management section, active surveillance, partial nephrectomy and radiofrequency ablation are presented. A separate chapter reviews the management of Von Hippel Lindau disease, and finally, conventional and aberrant signaling pathways are explored
    Note: English
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    Novel Aspects in Acute Lymphoblastic Leukemia (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533077536 , 9789535165736
    Language: English
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Oncology
    Abstract: Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of every one of its many facets, the chapters from many investigators from around the world nevertheless cover a number of relevant topics: aspects of the epidemiology of ALL in Hispanics, ophthalmologic manifestations of ALL, overviews of current therapy and drug-resistance mechanisms, novel biological pathways and targets, new drugs in development, and long-term consequences of CNS prophylaxis and therapy. The publishers and editor therefore hope that the prospective readers will find enough insight and information for their own endeavors
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  • 82
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    Molecular Targets of CNS Tumors (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533077369 , 9789535164968
    Language: English
    Pages: 1 Online-Ressource (688 p.)
    Keywords: Oncology
    Abstract: Molecular Targets of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on signaling pathway of the most common CNS tumor types. To develop drugs which specifically attack the cancer cells requires an understanding of the distinct characteristics of those cells. Additional detailed information is provided on selected signal pathways in CNS tumors
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  • 83
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    Current Management of Malignant Melanoma (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533072647 , 9789535164982
    Language: English
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Oncology
    Abstract: Management of melanoma is challenging, especially for the late stage of the disease. Development of new therapies and optimizing current treatments are being pursued in attempt to further improve the survival rate. The book provides up-to-date knowledge and experience in early diagnosis, prevention and treatment of melanoma as well as current ongoing clinical studies on melanoma. The book also provides the most recent perspectives of research on the molecular basis of melanoma, such as melanoma associated genes and a possible link between stress and melanoma
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  • 84
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    Myeloid Leukemia : Basic Mechanisms of Leukemogenesis (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533077895 , 9789535166085
    Language: English
    Pages: 1 Online-Ressource (498 p.)
    Keywords: Oncology
    Abstract: The current book comprises a series of chapters from experts in the field of myeloid cell biology and myeloid leukemia pathogenesis. It is meant to provide reviews about current knowledge in the area of basic science of acute (AML) and chronic myeloid leukemia (CML) as well as original publications covering specific aspects of these important diseases. Covering the specifics of leukemia biology and pathogenesis by authors from different parts of the World, including America, Europe, Africa, and Asia, this book provides a colorful view on research activities in this field around the globe
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  • 85
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    Breakthroughs in Melanoma Research (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533072913 , 9789535165644
    Language: English
    Pages: 1 Online-Ressource (644 p.)
    Keywords: Oncology
    Abstract: Melanoma is considered to be one of the most aggressive forms of skin neoplasms. Despite aggressive researches towards finding treatments, no effective therapy exists to inhibit the metastatic spread of malignant melanoma. The 5-year survival rate of metastatic melanoma is still significantly low, and there has been an earnest need to develop more effective therapies with greater anti-melanoma activity. Through the accomplishment of over 100 distinguished and respected researchers from 19 different countries, this book covers a wide range of aspects from various standpoints and issues related to melanoma. These include the biology of melanoma, pigmentations, pathways, receptors and diagnosis, and the latest treatments and therapies to make potential new therapies. Not only will this be beneficial for readers, but it will also contribute to scientists making further breakthroughs in melanoma research
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  • 86
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    Diagnostic Techniques and Surgical Management of Brain Tumors (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075891 , 9789535164937
    Language: English
    Pages: 1 Online-Ressource (546 p.)
    Keywords: Oncology
    Abstract: The focus of the book Diagnostic Techniques and Surgical Management of Brain Tumors is on describing the established and newly-arising techniques to diagnose central nervous system tumors, with a special focus on neuroimaging, followed by a discussion on the neurosurgical guidelines and techniques to manage and treat this disease. Each chapter in the Diagnostic Techniques and Surgical Management of Brain Tumors is authored by international experts with extensive experience in the areas covered
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  • 87
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    Prostate Cancer : Diagnostic and Therapeutic Advances (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533073194 , 9789535165903
    Language: English
    Pages: 1 Online-Ressource (392 p.)
    Keywords: Oncology
    Abstract: In this book entitled "Prostate Cancer - Diagnostic and Therapeutic Advances", we highlight many of the significant advances made in our treatment armamentarium of prostate cancer. The book is subdivided into four sections termed: 1) novel diagnostic approaches, 2) surgical treatments options, 3) radiation therapy and its potential sequelae, and 4) medical management and its treatment complications. After reading the present book , readers will be very familiar with the major clinical advances made in our multifaceted treatment approach to prostate cancer over the past decade.This book is a tribute to our pioneering urologists and allied healthcare professionals who have continually pushed forward our traditional therapeutic envelope
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  • 88
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    Glioma : Exploring Its Biology and Practical Relevance (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533073798 , 9789535165460
    Language: English
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Oncology
    Abstract: The tittle 'Glioma - Exploring Its Biology and Practical Relevance' is indicative of its content. This volume contains 21 chapters basically intended to explore glioma biology and discussing the experimental model systems for the purpose. It is hoped that the present volume will provide supportive and relevant awareness and understanding on the fundamental advances of the subject to the professionals from any sphere interested about glioma
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  • 89
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    Treatment of Metastatic Melanoma (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075747 , 9789535165132
    Language: English
    Pages: 1 Online-Ressource (362 p.)
    Keywords: Oncology
    Abstract: Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma
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  • 90
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    Melanoma in the Clinic : Diagnosis, Management and Complications of Malignancy (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075716 , 9789535164517
    Language: English
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Oncology
    Abstract: This book provides an excellent overview of how melanoma is treated in the clinic. Since oncologists and clinicians across the globe contributed to this book, each area also explores the unique burdens that geographical areas experience from melanoma subtypes and how these are treated in different settings. It also includes several chapters that illustrate novel methods for diagnosing melanoma in the clinic using new technologies, which are likely to significantly improve outcomes. Several chapters cover surgical techniques and other present very rare or challenging clinical cases of melanoma and how these were treated. The book is geared towards informing clinicians and even patients how melanoma arises, what tools are available and which decisions need to be made by patients and their families in order to treat this devastating disease
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  • 91
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    Acute Leukemia : The Scientist's Perspective and Challenge (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533075532 , 9789535166177
    Language: English
    Pages: 1 Online-Ressource (442 p.)
    Keywords: Oncology
    Abstract: This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients
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  • 92
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    Gastric Carcinoma : Molecular Aspects and Current Advances (2011)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
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    ISBN: 9789533074122 , 9789535164371
    Language: English
    Pages: 1 Online-Ressource (368 p.)
    Keywords: Oncology
    Abstract: Gastric cancer is one of the most common tumors worldwide. It has a heterogeneous milieu, where the genetic background, tumor immunology, oxidative stress, and microbial infections are key players in the multiple stages of tumorigenesis. These diverse factors are linked to the prognosis of the gastric cancer and the survival of gastric cancer patients. This book is appropriate for scientists and students in the field of oncology, gastroenterology, molecular biology, immunology, cell biology, biology, biochemistry, and pathology. This authoritative text carefully explains the fundamentals, providing a general overview of the principles followed by more detailed explanations of these recent topics efficiently. The topics presented herein contain the most recent knowledge in gastric cancer concerning the oncogenic signaling, genetic instability, the epigenetic aspect, molecular features and their clinical implications, miRNAs, integrin and E-cadherin, carbohydrate-associated-transferases, free radicals, immune cell responses, mucins, Helicobacter-pylori, neoadjuvant and adjuvant therapy, prophylactic strategy for peritoneal recurrence, and hepatic metastasis
    Note: English
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