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  • Undetermined  (385)
  • Basel : MDPI - Multidisciplinary Digital Publishing Institute  (384)
  • Montreal : McGill-Queen’s University Press (mqup)  (1)
  • Stuttgart : Klett
  • [Erscheinungsort nicht ermittelbar] : Taylor & Francis
  • Medicine  (385)
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Language
Years
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  • 1
    Online Resource
    Online Resource
    State of the Art in Idiopathic Pulmonary Fibrosis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563855 , 9783036563848
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: This reprint is a compilation of ten publications, including original-research and review articles, and the accompanying editorial within the scope of a Special Issue entitled: "State of the Art in Idiopathic Pulmonary Fibrosis" published in Cells
    Note: English
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  • 2
    Online Resource
    Online Resource
    In Silico Strategies for Prospective Drug Repositionings (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561349 , 9783036561332
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions
    Note: English
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  • 3
    Online Resource
    Online Resource
    Assessing Atmospheric Pollution and Its Impacts on the Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563213 , 9783036563206
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases
    Note: English
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  • 4
    Online Resource
    Online Resource
    Marine Toxins from Harmful Algae and Seafood Safety (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561943 , 9783036561936
    Language: Undetermined
    Pages: 1 Online-Ressource (264 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The rapid expansion of aquaculture around the world is increasingly being impacted by toxins produced by harmful marine microalgae, which threaten the safety of seafood. In addition, ocean climate change is leading to changing patterns in the distribution of toxic dinoflagellates and diatoms which produce these toxins. New approaches are being developed to monitor for harmful species and the toxins they produce. This Special Issue covers pioneering research on harmful marine microalgae and their toxins, including the identification of species and toxins; the development of new chemical and biological techniques to identify and monitor species and toxins; the uptake of marine biotoxins in seafood and marine ecosystems; and the distribution and abundance of toxins, particularly in relation to climate change
    Note: English
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  • 5
    Online Resource
    Online Resource
    Detection, Control and Contamination of Mycotoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563503 , 9783036563510
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The objective of this collection is to illustrate the most recent research on the development of novel and/or rapid methods for mycotoxin determination, and to propose new strategies for monitoring and/or reducing mycotoxin contamination. Innovative sample preparation techniques or protocols and the possibility of multiclass mycotoxin detection will be very positively considered for possible inclusion in this Special Issue. Both methods based on (bio)sensors and chromatography with various detectors (including mass spectrometry) are welcome. Applications of already published methods on new matrices without any modification will not be accepted. However, extensive studies and monitoring on the spread of contamination through the food production chain could be of interest for this collection
    Note: English
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  • 6
    Online Resource
    Online Resource
    Biomedical Imaging Technologies for Cardiovascular Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570068 , 9783036570075
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint aims to provide an update on the biomedical imaging technologies that can be used for cardiovascular diseases, including Doppler echocardiography, magnetic resonance imaging and positron emission tomography. Cardiovascular disease imaging assessment includes anatomy, hemodynamics, and tissue biomarkers, which aid the stratification of patient risk and therapy. In addition, this Special Issue includes articles that discuss the recent integration of artificial intelligence and machine learning, in order to support novel approaches to personalized image-based diagnosis
    Note: English
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  • 7
    Online Resource
    Online Resource
    Ciguatoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564289 , 9783036564296
    Language: Undetermined
    Pages: 1 Online-Ressource (358 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
    Note: English
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  • 8
    Online Resource
    Online Resource
    Biomaterials for Bone Tissue Engineering 2020 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561042 , 9783036561035
    Language: Undetermined
    Pages: 1 Online-Ressource (242 p.)
    Keywords: Medicine
    Abstract: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration
    Note: English
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  • 9
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    Online Resource
    Nutritional Support for Chronic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570624 , 9783036570631
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Medicine
    Abstract: Diet contributes to the development of many chronic conditions including obesity, cardiovascular disease, hypertension, stroke, type 2 diabetes, metabolic syndrome, some cancers, non-alcoholic fatty liver disease, and potentially some neurological diseases. This reprint addresses associations between diet (and specific nutrients including vitamin D) and various chronic diseases including obesity, cardiovascular disease, hypertension, stroke, diabetes, metabolic syndrome, non-alcoholic fatty liver disease, neurological conditions, and age-related macular degeneration. More specifically, the impacts of plant-based diets, dairy products, and ketogenic diets are explored in relation to chronic disease risk as well as some benefits of the consumption of oral nutritional supplements in the prevention of malnutrition and sarcopenia and in the treatment of wounds in individuals with diabetes. Additional topics that are covered include some roles of the fatty acid arachidonic acid in the body and the impact of cellular mitochondrial dysfunction on the progression of age-related macular degeneration. The effectiveness of a variety of nutraceuticals is covered as a means for the prevention or treatment of age-related macular degeneration. Lastly, the use of olive oil in reducing gut permeability in those with pre-diabetes is addressed, as well as the complex relationships of diet/food and of disease (metabolic syndrome) with the gut microbiota
    Note: English
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  • 10
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    Online Resource
    Urological Cancer 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569680 , 9783036569697
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine ; Oncology
    Abstract: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit
    Note: English
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  • 11
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    Clinical Features and Long-Term Outcomes of Systemic Lupus Erythematosus (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561103 , 9783036561097
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The clinical spectrum of systemic lupus erythematosus (SLE) is highly heterogeneous, ranging from mild disease, which can be limited to skin and joint involvement, to life-threatening conditions with renal impairment, severe cytopenias, central nervous system disease, and thromboembolic events. Apart from the host genetics, several environmental factors, such as sunlight, infections, drugs, and probably hormonal factors, can trigger the onset of symptoms related to SLE. Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE still have significant rates of premature mortality and many patients experience severe disease with increased risk of sustaining organ damage and having a reduced health-related quality of life. The development of effective drugs that can induce remission or low disease activity, the unanimous use of definitions of remission and low or high disease activity, flare, and response to therapy, the identification of non-invasive biomarkers of disease activity and long-term outcomes, and the implementation of SLE patients’ perspectives as an integral part of the clinical assessment constitute only a few of the many unmet needs in the field of SLE
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  • 12
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    Advanced Blood-Brain Barrier Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564173 , 9783036564166
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB)
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  • 13
    Online Resource
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    Induced Impairment of Neurogenesis and Brain Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562148 , 9783036562131
    Language: Undetermined
    Pages: 1 Online-Ressource (282 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders
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  • 14
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    Antimicrobial Therapy in Intensive Care Unit (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567693 , 9783036567686
    Language: Undetermined
    Pages: 1 Online-Ressource (260 p.)
    Keywords: Medicine
    Abstract: This reprint is an excellent collection of articles that deal with difficult-to-treat infections in the ICU environment. Multiresistant bacteria and fungi create severe treatment problems to the physician charged with their care. We hope that this book will help everyday dilemmas and add useful information on difficult topics
    Note: English
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  • 15
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    Immunohistochemical and Physiological Research on Farm Animals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568829 , 9783036568836
    Language: Undetermined
    Pages: 1 Online-Ressource (318 p.)
    Keywords: Medicine
    Abstract: This reprint represents a collection of papers that aimed to highlight the importance of immunohistochemical findings and their role in improving the understanding of organ tissue functions. We focused our attention on farm animals because they represent not only a source of food in the supply chain, but also a source of income for breeders, a source of employment, and a primary tool in the quest for sustainable food production. To achieve this last aim, we asked authors for research that could potentially be applied to the purpose of this study, and whose results could be useful in improving farm management practices and the responsible use of natural resources. A total of 20 papers were contributed to this issue, written by 118 authors from 4 countries, and comprising 18 research articles and 2 communications articles
    Note: English
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  • 16
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    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis : Diagnosis and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559698 , 9783036559704
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches
    Note: English
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  • 17
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    A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569185 , 9783036569192
    Language: Undetermined
    Pages: 1 Online-Ressource (414 p.)
    Keywords: Medicine ; Physiology
    Abstract: This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology
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  • 18
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    Sensor Technology for Sports Monitoring (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570884 , 9783036570891
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine
    Abstract: In order to be able to analyze and give proper advice on sport techniques, it is important to understand the biomechanical and physiological demands of different sports. In a coaching situation, feedback to the athlete should be given without too much delay. Over the past decades, sensor technology-related to sports monitoring has developed with huge steps. Senors are lighter, data transmission is mostly wireless, and software applications are more user-friendly. This reprint is addressed to all kinds of sensors that are currently being used for monitoring different sports
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  • 19
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    Nutrition at the Interface of Sleep and Circadian Rhythms: Implications for Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567082 , 9783036567099
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: An integral part of homeostasis includes daily rhythms in physiology, behavior, and metabolism. The circadian timing system enables organisms to adapt their biological functions to the cyclic nature of the Earth. Sleep is a fundamental physiological function, playing a crucial role in physical, mental and emotional health. Alterations of sleep quality and quantity caused by modern lifestyle and behavior as well sleep disorders are associated with an increased risk for chronic diseases. Chronic misalignment of endogenous rhythms can also lead to metabolic dysfunction. Research is starting to demonstrate the complex interrelationship between nutrition, sleep and the circadian system. For example, some foods and nutrients may impact the availability of substances that influence sleep. On the other hand, inadequate sleep is associated with an unhealthy nutrient intake and altered metabolism. Nutrients can act as drivers of circadian rhythms; they have the ability to influence circadian regulation and alter biological functions in specific tissues. A lacuna still exists in the knowledge surrounding the interplay of nutrition with sleep and the circadian system. In light of this, novel opportunities are disclosed for developing tailored nutritional recommendations with beneficial effects on sleep and circadian rhythmicity so as to improve life quality and prevent disease. The purpose of this Special Issue is therefore to collect contributions regarding this interplay and the related clinical implications
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  • 20
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    Challenges and Opportunities for Effective Cancer Immunotherapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569604 , 9783036569611
    Language: Undetermined
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Medicine
    Abstract: Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments
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  • 21
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    Biosimilars in Europe (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565750 , 9783036565743
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries
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  • 22
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    Hyperbaric Medicine (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564678 , 9783036564661
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine
    Abstract: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars
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  • 23
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    Focus on Antibiotics – New Challenges and Steps Forward in Discovery and Development (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572017 , 9783036572000
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The Special Issue "Focus on Antibiotics - New Challenges and Steps Forward in Discovery and Development" addresses the latest efforts towards discovering new antibiotics. The articles in this Special Issue cover various topics concerning antibacterial drugs. They provide valuable insights into the challenges and opportunities facing the field of antibiotic research and offer innovative solutions to tackle the growing problem of antibiotic resistance. The content of this Special Issue addresses antibacterial quinolones of the latest generation, new tetracyclines (such as glycylcyclines, aminomethylcyclines, and fluorocyclines), metal complexes (Ru (II/III) frameworks and Co(III) complexes with diamine chelate ligands), various nanoparticles (gold, silver and titanium dioxide nanoparticles), bioactive compounds produced by Mixobacterials species, anti-mycobacterial compounds acting as phosphopantetheinyl transferase inhibitors. The research in this Special Issue will contribute to pharmaceutics and ultimately contribute to developing new and effective antibiotics. We are grateful to the authors for their contributions and hope this Special Issue will stimulate further research and discussion on antibiotics. We also thank the reviewers for their time and expertise, and the editorial team for supporting this Special Issue. Finally, we hope this Special Issue will serve as a valuable resource for researchers, clinicians, and policymakers working towards a future where antibiotics remain vital in our fight against infectious diseases
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  • 24
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    Tryptophan in Nutrition and Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570778 , 9783036570761
    Language: Undetermined
    Pages: 1 Online-Ressource (324 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society
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  • 25
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    Chemical and Biological Threats, Hazard Potential and Countermeasures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036550374 , 9783036550381
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: In this Special Issue of Toxics entitled, “Chemical and biological threats, hazard potential and countermeasures”. In this special issue we would like to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally or on purpose endanger human health. Besides the characterization of such threats and their biological consequences we will focus on the available and novel experimental countermeasures capable to protect from and/or threat such exposures
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  • 26
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    Endocrine and Neuroendocrine Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036557632 , 9783036557649
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Oncology
    Abstract: Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available. This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives
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  • 27
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    Advances in Neuroimaging Data Processing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569987 , 9783036569994
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications
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    State-of-the-Art in Orthodontics and Gnathology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569369 , 9783036569376
    Language: Undetermined
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medicine
    Abstract: The objective of this reprint is to present the main evidence-based data on new developments and knowledge in diagnostic and treatment technologies in the orofacial field used in both children and adults. The published content has been met with great success in interdisciplinary fields, stimulating international authors to submit their original articles, reviews, or case reports based on various aspects of orthodontics as well as on the diagnosis and management of temporomandibular disorders and orofacial pain. Among the current highly debated topics, this reprint focuses on multiple disciplines as follows: gingival recessions and periodontal status after orthodontic treatment; a rare case of impacted central incisors; predictors of analgesic consumption in orthodontic patients; a systematic review about different dentoskeletal class III treatment approaches; evaluation of upper airway volumes; and cephalometric values in JIA patients
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  • 29
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    3D Printed Materials Dentistry (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036568881 , 9783036568898
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine ; Pharmacology ; Research & information: general ; Chemistry
    Abstract: The Special Issue reprint covers a wide range of applications of 3D-printing in dentistry. Five out of eleven research papers deal with applications of 3D printing in orthodontics, one study presents a 3D-printed fitting system for the FFP2 that were applied during the COVID-19 pandemic, and the others address applications in prosthodontics and restorative dentistry
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570419 , 9783036570402
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy
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    Molecular Mechanisms of Steroid Hormone Biosynthesis and Action (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570037 , 9783036570020
    Language: Undetermined
    Pages: 1 Online-Ressource (360 p.)
    Keywords: Medicine
    Abstract: Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones
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    Artificial Intelligence in Cancer Diagnosis and Therapy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566726 , 9783036566733
    Language: Undetermined
    Pages: 1 Online-Ressource (672 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint covers some significant impacts in the recent research in both the private and public sectors of cancer diagnosis and therapy, in which Artificial Intelligence (AI) and Machine Learning are significant. This reprint is also a collection of forty different complex and challenging problems arranged in five groups: AI in prognosis, grading, and prediction, AI in clinical image analysis, AI models for pathological diagnosis, ML and statistical models for molecular cancer diagnostics and genetics, and AI in triage, risk stratification, and screening cancer, which are all focused on using AI in cancer diagnosis and therapy. All the necessary concepts, solutions, methodologies, and references are supplied except for some fundamental knowledge that is well-known in the general fields of AI and cancer diagnosis and therapy. The readers may, therefore, gain the main concepts of each chapter, with as little of a need as possible to refer to the concepts of the other chapters and references. The readers may hence start to read one or more chapters of the book for their own interests
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    Thrombolysis and Thrombectomy in Acute Ischemic Stroke (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575988 , 9783036575995
    Language: Undetermined
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke
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    Auditory and Phonetic Processes in Speech Perception (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574134 , 9783036574127
    Language: Undetermined
    Pages: 1 Online-Ressource (298 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: In the past two decades, great advancements have been made in phonetic, auditory, and psycholinguistic research on speech perception. As the fields have advanced, there has been increasing interdisciplinary collaboration between them, which has, in turn, revealed their interdependence. The aim of this Special Issue is to bring together top scholars in these three related areas to present research in a single volume with papers ranging from the neurophysiology of hearing, to phonetic and linguistic factors, to factors related to hearing loss and assistive devices, second language learning and accentedness, and the processing of speech and the mental lexicon. We invite you all to read the high-quality papers in this Special Issue
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    Oxidative Stress in Parasites (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576176 , 9783036576169
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Parasitic infections pose a significant public health challenge, particularly in developing countries, and can lead to long-term illness, disability, and even death. This reprint focuses on parasitic diseases and how parasites respond to the oxidative and nitrosative stress generated by the host's immune system. The articles in this Special Issue cover various aspects of this topic, including the localization of parasites within the host, the impact of nutrition and drugs, and the role of the host's immune defense cells in the parasitic response to oxidative and nitrosative stress. Understanding the mechanisms underlying parasitic diseases is crucial for developing innovative treatments that can target parasites' defense against oxidative stress. This Special Issue serves as a valuable resource for researchers, students, and physicians interested in parasitic infections
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    Novel Approaches for Overcoming Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576992 , 9783036576985
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery
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    Carbazole Derivatives: Latest Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572888 , 9783036572895
    Language: Undetermined
    Pages: 1 Online-Ressource (98 p.)
    Keywords: Medicine
    Abstract: Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, “Carbazole derivatives: latest progress and prospects”, recent studies on carbazole derivatives that are utilized, such as β1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported
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    New Insights into Contraception (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572765 , 9783036572772
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine
    Abstract: Today, a great variety of contraceptive techniques are available to women; this, coupled with improving the educational levels of female children and adults, is hastening a decline in fertility and consequently, population growth. With the advent of sustained fertility rates lower than replacement levels in many countries, including China and India, we are already witnessing major economic, social, environmental, and geopolitical consequences. Given this situation, today, the promotion of the use of contraception means improving health, not demography, placing emphasis on individuals and not just on methods alone; on the quality of services, and not simply on availability. Indeed, there is an increasing awareness that contraception can help women reduce health risks that are associated with reproductive events and specifically, with unwanted pregnancies. This means that, no matter how ideal a method may be from a purely scientific viewpoint, it must be submitted to the free, decision-making of well-informed women. To contribute to this new user-centric perspective, this reprint presents a series of articles in which technology is considered withing the broader concept of women’s health. Five articles deal with issues related to the users’ and providers’ perspectives; three discuss a modality that is receiving increasing attention, the so-called Long-Acting Reversible Contraception (LARC); and the last three contributions highlight the new advances in oral hormonal contraception
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    Environmental Exposure to Toxic Chemicals and Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572697 , 9783036572680
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors
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    Immunotherapy in Hepatocellular Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566917 , 9783036566900
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Oncology
    Abstract: Based on this evidence, a deep understanding of the immunological status and biological targets modulating immunological microenvironments should be quite informative for the development of future immunotherapy in HCC. From this point of view, this Special Issue will highlight the current state of the art in the immunotherapy of HCC from both the basic and clinical perspectives, and outline future perspectives for improving therapies
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    Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036583839 , 9783036583822
    Language: Undetermined
    Pages: 1 Online-Ressource (400 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint contains five original research papers and eight review articles for the Special Issue "Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components" which is guest edited by Prof. Dr. Anupam Bishayee. There is one item that indicated the correction of one review
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    Artificial Intelligence (AI) and Machine Learning (ML) in Medical Imaging Informatics towards Diagnostic Decision Making (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036581286 , 9783036581293
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine
    Abstract: In recent years, AI/ML tools have become more prevalent in the fields of medical imaging and imaging informatics, where systems are already outperforming physicians in a range of domains, such as in the classification of retinal fundus images in ophthalmology, chest X-rays in radiology, and skin cancer detection in dermatology, among many others. It has recently emerged as one of the fastest growing research areas given the evolution of techniques in radiology, molecular imaging, anatomical imaging, and functional imaging for detection, segmentation, diagnosis, annotation, summarization, and prediction. The ongoing innovations in this exciting and promising field play a powerful role in influencing the lives of millions through health, safety, education, and other opportunities intended to be shared across all segments of society. To achieve further progress, this Special Issue (SI) invited both research and review-type manuscripts to showcase ongoing research progress and development based on applications of AI/ML (especially DL techniques) in medical imaging to influence human health and healthcare systems in the diagnostic decision-making process. The SI published fourteen articles after a rigorous peer-review process across the spectrum of medical imaging modalities and the diversity of specialties depending on imaging techniques from radiology, dermatology, pathology, colonoscopy, endoscopy, etc
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    The Biological and Clinical Aspects of Merkel Cell Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574462 , 9783036574479
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Oncology
    Abstract: In this Special Issue, we sought advanced knowledge in both basic and clinical research presented in original articles and comprehensive reviews highlighting the latest advances in MCC. Articles focus on but were not restricted to the molecular basis of the disease, translational investigations of biomarkers for prospective clinical applications, and innovative diagnostic and therapeutic approaches in MCC
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    Pathogenesis and Novel Therapeutics in Asthma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036578422 , 9783036578439
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medicine
    Abstract: Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment is eosinophilic asthma; however, even in some of these patients, anti-IL5 treatment is ineffective. Furthermore, about a quarter of patients, especially those with a severe phenotype, develop progressive and irreversible airway obstruction, leading to persistent symptoms despite optimized treatment. Therefore, new therapeutic approaches are still needed, particularly in severe asthma. The Special Issue presents asthma research focusing on modern personalized therapeutic approaches. Particular interest is directed to novel asthma biomarkers, including molecular and epigenetic ones, shining new light on pathogenesis, phenotyping, and customized therapy in various airway inflammatory patterns of the disease. In addition, research articles on airway epithelial cell dysfunction, airway remodeling, and the overlap between asthma and chronic obstructive pulmonary disease are welcomed. Stanislawa Bazan-Socha (Guest Editors)
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    Zirconia and Innovative Biomaterials for Dental and Biomedical Applications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036578156 , 9783036578149
    Language: Undetermined
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Medicine
    Abstract: This reprint provides a comprehensive overview and critically explores the recent trends in the zirconia additive manufacturing process or 3D printing and various surface treatments and their characterization for application in the dental and biomedical fields. It will be a valuable resource for the researchers to design or fabricate the implants according to clinical demands
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  • 46
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    Breast Cancer Imaging and Therapy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579306 , 9783036579313
    Language: Undetermined
    Pages: 1 Online-Ressource (228 p.)
    Keywords: Medicine ; Oncology
    Abstract: In Canada, survival from breast cancer has steadily increased since 1989, and breast cancer mortality has decreased by 48%. While 82% of women with breast cancer are diagnosed at stage 1 or 2, there are still 18% who present at a late stage and 25% who develop metastatic disease. Improved survival has been achieved through early diagnosis of breast cancer with screening, allowing for more effective and targeted treatments. This reprint summarizes the latest evidence on the early detection of breast cancer and highlights areas where this may be improved
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    Respiratory Disease in the COVID-19 Era (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579160 , 9783036579177
    Language: Undetermined
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Coronavirus disease 2019 (COVID-19) is a new respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused a global pandemic. COVID-19 patients often develop acute respiratory distress syndrome (ARDS), which involves acute and lethal respiratory failure. In a meta-analysis, the median incidence of ARDS in COVID-19 patients was found to be 35 (2-79)%, while the mortality rate in COVID-19-associated ARDS patients was found to be 39 (12.5-73.1)% (Hasan, et al. Expert Rev Repoir Med. 2020; 14: 1149). As of 12 December 2021, 270,373,764 cases had been confirmed as COVID-19 and 5,321,321 cases had resulted in death, according to the World Health Organization webpage. Various symptoms such as persistent fatigue, myalgia, and insomnia can persist after recovery from COVID-19; these symptoms are called “long COVID-19”. Patients with COVID-19 who survive but develop pulmonary fibrosis may experience persistent dyspnea upon exertion, a decrease in pulmonary function, and/or a radiological abnormal shadow. Antifibrotic drugs including nintedanib and pirfenidone are candidate drugs for the treatment of pulmonary fibrosis due to COVID-19; randomized controlled trials are ongoing. However, there are limited studies about respiratory disease caused by COVID-19. Given the clinical significance of this topic and its impact on clinical practice and public health, Medicina have published a Special Issue entitled “Respiratory Disease in the COVID-19 Era” with the aim of gathering accurate and up-to-date scientific information of this topic
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    Application of Botulinum Neurotoxin in Lower Urinary Tract Dysfunctions: Where Are We Now? (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579382 , 9783036579399
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Medicine
    Abstract: Evidence has shown that botulinum toxin A has advantages in lower urinary tract dysfunctions (LUTDs), especially in interstitial cystitis, urethral sphincter dysfunction, and inflammatory bladder disorders which currently cannot be adequately treated with oral pharmacological medications. This Special Issue has collected original or review articles that focus on the novel applications of botulinum toxin A in LUTDs. The research has been updated and contains novel therapeutic applications of botulinum toxin for bladder or urethral dysfunctions. This Special Issue of Toxins provides current knowledge surrounding the status of botulinum toxin in functional urology and LUTDs
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    Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579375 , 9783036579368
    Language: Undetermined
    Pages: 1 Online-Ressource (184 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint brings together a group of articles that were published as a Special Issue on prosthetic joint infection in the journal Antibiotics. They cover various aspects of risk factors and prevention, medical and surgical treatment, and outcomes of prosthetic joint infections
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  • 50
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    Research of Pathogenesis and Novel Therapeutics in Arthritis 3.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036580845 , 9783036580852
    Language: Undetermined
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Arthritis has a high prevalence globally and includes over 100 types; the most common types are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used for the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of a heart attack and other cardiovascular problems. Therefore, it is crucial that we continue to research the pathogenesis of arthritis and novel modes of therapy. This reprint summarizes and discusses the themes of 19 articles published in our Special Issue “Research of Pathogenesis and Novel Therapeutics in Arthritis 3.0”. The reprint details important novel research discoveries that contribute to our current understanding of arthritis
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    Therapeutic Potential for Cannabis and Cannabinoids (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575827 , 9783036575834
    Language: Undetermined
    Pages: 1 Online-Ressource (424 p.)
    Keywords: Medicine
    Abstract: Cannabis has a history of medical use dating back millennia; however, the use of cannabis for medicinal purposes fell out of favor in the middle of the last century. There is currently a renewed interest in the potential medicinal value of this plant, as well as individual compounds produced by Cannabis (as well as synthetic analogs). Currently, nearly 50 countries permit the medical use of cannabis, and over a dozen other countries have legalized cannabis-based products (CBD, Sativex, Dronabinol, etc.) for medical use. While there exists a plethora of anecdotal reports indicating that cannabis can treat a variety of diseases, there is a limited amount of strong, evidence-based scientific data to support these claims. This Special Edition of Biomedicines, “Therapeutic Potential for Cannabis and Cannabinoids”, was dedicated to providing evidence for the medicinal value of cannabis to treat human illness and disease. Topics included, but were not limited to, preclinical animal models examining the efficacy of cannabis and cannabinoid derivatives on pain, anxiety, cancer, and other diseases; and cell and molecular models of cannabinoid pharmacokinetics, drug–drug interactions, and disease treatment. These studies are of great importance not only for progressing the cannabis field, but also for validating the use of cannabis and cannabinoids as therapeutics
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    Comparative Pathology and Immunohistochemistry of Veterinary Species (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579948 , 9783036579955
    Language: Undetermined
    Pages: 1 Online-Ressource (154 p.)
    Keywords: Medicine
    Abstract: Comparative pathology, translational research, and clinical trials involving domestic animals have the ultimate goal of advancing our medical knowledge of both human and veterinary species. Companion, laboratory (from mouse to non-human primates), and wildlife animals play a pivotal role in our understanding of infectious diseases—particularly those with a zoonotic component. This reprint focuses on fundamental and applied research on the comparative pathology and immunohistochemistry of veterinary species. A total of 11 high-quality papers addressing different areas of pathology have been contributed by 62 authors from seven countries, comprising 9 research articles and 2 communications
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    Optical Coherence Tomography Imaging: Advances in Ophthalmology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592503 , 9783036592510
    Language: Undetermined
    Pages: 1 Online-Ressource (254 p.)
    Keywords: Medicine
    Abstract: The advent of optical coherence tomography (OCT) has arrived in an era in which the in vivo, cross-sectional imaging of both the retina and choroid is possible. Infra-red rays of light are used to image the chorioretinal layers with an image resolution reaching 10-15 microns. During the last three decades, OCT technology has undergone several improvements, such as spectral domain OCT (SD-OCT), swept source OCT (SS-OCT), enhanced depth imaging (EDI-OCT), wide field OCT, intraoperative OCT, OCT angiography (OCTA), and adaptive optics OCT. These enhancements help in both the qualitative and quantitative analysis of chorioretinal parameters in pathologies such as macular edema, neurosensory detachment, retinoschisis, macular holes, epiretinal membranes, and choroidal tumors. An added advantage is the role of OCT in the evaluation of optic disc disorders, including optic neuritis and glaucoma, via the quantitative analysis of the retinal nerve fiber layer. Moreover, OCT being non-invasive provides an opportunity for serial imaging during follow-up visits. Overall, OCT imaging provides tissue details, closely mimicking the histopathology, and is an invaluable asset in the armamentarium of retina physicians. This special issue includes applications of OCT in various chorioretinal disorders
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    Fatty Acids from Marine Organisms (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590882 , 9783036590899
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Fatty acids (FAs) are considered very important biomolecules because they have been used as trophic biomarkers in the marine food chain analysis of several ecological niches. They are compounds universally present in all organisms and play very important biological roles, such as acting as building blocks in biological membranes and signaling molecules. A great number of different fatty acids (saturated, mono- and di-unsaturated, branched, halogenated, hydroxylated, and methoxylated), as well as the major polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, occur in marine organisms. In addition, marine organisms are a rich source of metabolites with unusual structures that often exhibit interesting pharmacological properties. Moreover, it is worth emphasizing that the nutritional value of fish and marine invertebrates directly depends on their lipid composition and, in particular, their fatty acid profile, and this represents the basis of the trade of most international marine products. For this Special Issue, we invited academic and industry scientists to submit reviews and original research articles focusing on the chemistry, biological roles, and bioactivities of fatty acids from marine organisms
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    Breast Cancer—Therapeutic Challenges, Research Strategies and Novel Diagnostics (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594439 , 9783036594422
    Language: Undetermined
    Pages: 1 Online-Ressource (282 p.)
    Keywords: Medicine
    Abstract: Thanks to the breast cancer research of recent decades, effective methods and strategies have been established, allowing the mortality rates of breast cancer patients to decrease more and more. However, we still face many challenges. The role of certain biomarkers or mutations is still not clear for treatment and surveillance. Novel drugs are often associated with a different spectrum of adverse events than that seen for conventional therapies, accordingly having an impact on patients’ compliance behaviors. In breast cancer surgery, in some cases, the question remains whether to escalate or deescalate. Additionally, with regard to diagnostics, in a digitalized world, home-based tools and therapy monitoring options are of high importance, especially under the tough conditions and supply problems seen during the COVID-19 pandemic.This Special Issue gathers original research articles and reviews demonstrating therapeutic challenges, current research strategies, and novel diagnostics in breast cancer
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    Therapeutic Landscapes in Colorectal Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594415 , 9783036594408
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Oncology
    Abstract: The Special Issue, titled “Therapeutic Landscapes in Colorectal Carcinoma”, illustrates a stimulating collection of articles written by international specialists that can promote discussions and ideas among colleagues working on CRC. It provides us with a deeper insight into the latest advances involving knowledge on CRC from scientific, translational, and clinical points of view. Through this Special Issue, our main purpose was to shed light on some state-of-the-art research on CRC. Here, the reader will find papers on prognostic factors as well as responses to neoadjuvant and adjuvant CRC treatments. Finally, we discuss the research trends and hotspots for CRC therapies that emerged during the COVID-19 pandemic, such as the potential achievement of a transition from CRC clinical research to precision medicine, together with a special emphasis given to new single-cell-based techniques. We hope that it can encourage translational and interdisciplinary collaborations, leading to a definitive understanding of strategies to overcome and inhibit CRC progression and metastasis
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    Application of Retinal and Optic Nerve Imaging in Clinical Medicine 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591803 , 9783036591810
    Language: Undetermined
    Pages: 1 Online-Ressource (114 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint discussed the role of retinal and optic nerve imaging in addition to its application in ophthalmic diseases and clinical medicine. It includes some high-quality articles containing original research results as well as review articles of exceptional merit
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    Ophthalmic Drug Delivery, 2nd Edition (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036587998 , 9783036587981
    Language: Undetermined
    Pages: 1 Online-Ressource (316 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies
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    Anesthetic Management in Perioperative Period (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036593661 , 9783036593678
    Language: Undetermined
    Pages: 1 Online-Ressource (462 p.)
    Keywords: Medicine
    Abstract: There are a variety of anesthetic management options during surgery, and these are constantly evolving. Both innovative and confirmatory research are important if the scientific community aims to develop and improve people’s quality of care. This reprint introduces new avenues and covers questions regarding innovative anesthetic techniques and unmet needs after surgery, paving the way for future improvements. It can be useful for both clinicians and clinical researchers, especially in light of the expansion of concepts like personalized care
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    Translational Research in Audiology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036591612 , 9783036591605
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Medicine
    Abstract: This collection brings together basic and clinical research papers that cover different topics in audiology but have one thing in common: the translational approach. The research in this collection demonstrates how exciting and interesting translational audiology can be. This collection aims to stimulate interest and encourage more studies of this type
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    Advances in Cardiac Electrophysiology and Pacing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036590783 , 9783036590790
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Today, interventional treatment and clinical management of cardiac arrhythmias represent a continuous challenge. This is mainly due to the widening of indications for implantable electronic devices and for catheter ablation procedures as well as the continuous improvement of technologies and medical therapies. Despite international guidelines and worldwide consensus updates, evidence gaps persist at all points in the real-world setting. This Special Issue aims to provide a comprehensive overview of advances in the indications, diagnosis, and treatment of cardiac rhythm disturbances, with particular interest in the use of innovative techniques and technologies in interventional therapies
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    Head and Neck Surgery: Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036592480 , 9783036592497
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine
    Abstract: As Guest Editors, we are very delighted to see the reprint of our Special Issue, “Head and Neck Surgery: Clinical Updates and Perspectives", which is published in the Otolaryngology section of the Journal of Clinical Medicine. These papers are the joint effort of many excellent colleagues who have devoted their lives and careers to the exciting field of Otorhinolaryngology. As both clinicians and surgeons, we are actively advancing the diagnosis and management of the myriad of conditions affecting the head and neck region. Unprecedented discoveries in the field of genetics and molecular biology are always integrated with sound knowledge of the intricate anatomy of our discipline, while technological advancements now permit us to provide tailored and minimally invasive treatments for our patients. We wish to thank all the authors who contributed to this publication and we hope you enjoy reading it
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    Aortic Aneurysms: Vascular Remodeling and Repair (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036589022 , 9783036589039
    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Aortic aneurysm is a multifactorial progressive life-threatening disease. Recent surgical treatment and endovascular repair help to prevent aortic ruptures. However, there are no effective pharmacological treatments to limit aneurysm growth. This Special issue, entitled “Aortic Aneurysms: Vascular Remodeling and Repair", represents a collection of articles from innovative scientists that focuses on the recent advances in diagnostics, pathogenesis and therapies of aneurysms. This reprint includes a systematic review and nine original papers on clinical imaging, prognostic methods, genome-wide screening, novel cell signaling pathways and drug targets. We hope that readers will gain a deeper understanding of this topic and enjoy reading this reprint
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    The 10th International Seminar of Veterinary Medicine : Camelids in Algeria & Maghreb (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036574806 , 9783036574813
    Language: Undetermined
    Pages: 1 Online-Ressource (94 p.)
    Keywords: Medicine
    Abstract: This book is a collection of articles focused on recent research covering a species which is emblematic of scientific and commercial interest—the dromedary. The dromedary economy and its sustainability are of a capital importance for the future development of humanity. This research highlights camel productions systems and rearing practices, camel biodiversity and genetics, camel breeding and feeding, dromedary pathologies, anatomy particularities in dromedary, therapeutic virtues of camel products, as well as the industry’s contribution to food security
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    Novel Anticancer Strategies (Volume II) (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570334 , 9783036570327
    Language: Undetermined
    Pages: 1 Online-Ressource (700 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells
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    Model-Informed Precision Dosing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568966 , 9783036568973
    Language: Undetermined
    Pages: 1 Online-Ressource (320 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs
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    Advanced Research on Animal Venoms in China (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036574349 , 9783036574356
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Recently, Chinese researchers have made significant progress in animal venom research in comprehending the diversity and complexity of these molecules and their potential applications in medicine, biotechnology, and as research tools. Advancements in 'omics' technologies such as proteomics, genomics, and transcriptomics have empowered Chinese researchers to identify and analyze venom-coded genes and proteins, revealing a kaleidoscope of novel peptide toxins with diverse functions and activities. The reprint focus on the perspective on some of the most recent and dynamic contributions of animal toxins research by Chinese researchers. The purpose of this reprint is to provide the latest work by Chinese researchers on the discovery of animal toxins, the mechanism underlining their actions, the mining of drug leads from peptide toxins, and the diagnosis and treatment of bites or stings by venomous animals
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    The Digital Health in the Pandemic Era (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036577333 , 9783036577326
    Language: Undetermined
    Pages: 1 Online-Ressource (298 p.)
    Keywords: Medicine ; Mental health services
    Abstract: Digital health, virtual assistance, and telemedicine are terms often used interchangeably to refer to remote medical assistance, monitoring and care. Several studies and insights have developed these issues, analyzing the advantages and disadvantages and successes and failures and offering reflections on the implications and issues of these technologies in the health domain. The results of these investigations are affecting the redesign of hospital and outpatient management based on digital innovation using eHealth and mHealth. During the COVID-19 pandemic, this approach made it possible to offer assistance and continue care at home, protecting patients, preserving health workers, limiting the spread of the virus, and reducing the need for hospitalization. This reprint contains contributions dealing with the development of DH during the COVID-19 pandemic. The contributions are from various experts in different fields regarding the application of digital health, which, in some cases is also integrated with artificial intelligence, including digital contact tracing, mHealth, virtual reality, mental health, physiology, and rehabilitation
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    Optic Neuropathies : Current and Future Strategies for Optic Nerve Protection and Repair (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575056 , 9783036575049
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine
    Abstract: Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma
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    Agricultural Products Processing and Postharvest Storage (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036574165 , 9783036574172
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Agricultural products such as fruit, vegetables, and cereal are believed to be some of the most crucial sources of certain phytonutrients necessary for humans, such as vitamins, dietary fibers, and minerals. However, agricultural products are prone to quality deterioration during storage under ambient temperatures. Currently, the annual post-harvest loss rate of agricultural products can reach up to 20–30%. Owing to their perishable nature, the development of processing and preservation technologies for agricultural products is an important research topic closely associated with the national economy and people’s livelihoods that has attracted ever-increasing attention. In view of the prominent issues of high energy consumption, high costs, serious pollution, and low-quality properties in agricultural product manufacturing, our journal mainly focuses on research articles on novel techniques and the underlying mechanisms of the processing, preservation, and quality control of agricultural products, so as to promote the upgrading and updating of the agricultural product industry
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    Strategies to Enhance Drug Permeability across Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574639 , 9783036574622
    Language: Undetermined
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Overcoming biological barriers is a significant challenge in drug development, and recent advancements in drug delivery systems and technologies offer promising solutions. This Special Issue highlights the innovative approaches and techniques being used to improve drug permeability and absorption, as well as their potential impact on a wide range of therapeutic goals. These advancements being made in drug delivery and permeability offer exciting possibilities to improve patient outcomes
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    Recent Advances in Dual Disorders (Addiction and Other Mental Disorders) (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577005 , 9783036577012
    Language: Undetermined
    Pages: 1 Online-Ressource (162 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Dual disorders, meaning the coexistence in the same individual of a substance use disorder and another mental disorder, have become an area of great interest in the fields of psychiatry and addiction and in health overall due to their high prevalence, clinical relevance and multicultural presence. This book includes a compilation of papers published between the end of 2021 and the beginning of 2023 focused on recent advances in dual disorders. The contributions present a broad look at various relevant aspects. Among them are the characterization of patients treated in different services, with special interest in the risk of overdoses, suicidal attempts and HIV, as well as the so-forgotten gender perspective and the impact of the COVID-19 pandemic on the attention of addiction centers. One of the first studies to consider the comorbidity of gambling disorders with substance use is also presented. The possible usefulness of explanatory models of machine learning for diagnosis and for performing chronobiological measurements that allow a more individualized treatment stand out among the novel contributions to the field of dual disorders. The aim of each of the contributions of this reprint is to be transferred for the benefit of clinical practice
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    Biomarkers in Neurodegenerative Diseases 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036557311 , 9783036557328
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine
    Abstract: This book follows up on the previous volume focusing on the different biomarkers for neurodegenerative diseases. It includes original research works and review articles focusing on an improved understanding of disease mechanisms. It also aims to identify aspects of early therapeutic intervention for enhanced disease management. Some critical approaches include studies involving human tissue samples, mouse disease models, and different imaging techniques. These studies present the essential information necessary to address such pathological conditions in the future
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    Orthopedics and Trauma in Children (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036576954 , 9783036576947
    Language: Undetermined
    Pages: 1 Online-Ressource (272 p.)
    Keywords: Medicine
    Abstract: Discover the complexities of pediatric orthopedics in this comprehensive reprint book. Pediatric orthopedics present unique challenges in diagnosis and treatment, necessitating the expertise of skilled specialists. Congenital, developmental, and acquired orthopedic issues, including infectious, neuromuscular, nutritional, neoplastic, psychogenic, and traumatic conditions, are explored. With a focus on evidence-based recommendations, this book addresses the management of orthopedic deformities in children by considering different clinical scenarios. From upper and lower limb injuries to severe trauma, readers will gain insights into decision-making processes for reconstruction or amputation. As a valuable resource for orthopedic surgeons, pediatricians, and healthcare professionals, this reprint fills knowledge gaps to optimize patient care
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    Challenges and Perspectives of Neurological Disorders (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575032 , 9783036575025
    Language: Undetermined
    Pages: 1 Online-Ressource (146 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: This reprint offers a comprehensive and updated overview of the current state-of-the-art techniques in the management of various neurological disorders. These disorders include neurodegenerative diseases, neurovascular disorders, and neuro-oncological diseases. The reprint also presents the latest advances and innovations in the diagnosis, treatment, and prevention of these complex conditions, emphasizing the role of cutting-edge technologies, such as neurobiology, neuroimaging, neuroinformatics, neuropharmacology, and neurosurgery. This reprint is a useful resource for researchers, clinicians, students, and anyone interested in the current challenges and perspectives of neurological disorders
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    Targeting Inflammation and Inflammatory-Related Diseases with Natural Bioactives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572970 , 9783036572963
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate cellular infiltration, consequentially bringing about the resolution of inflammatory responses and the restoration of tissue integrity. However, persistent inflammatory stimuli or the disregulation of the mechanisms of the resolution phase can lead to chronic inflammation and inflammatory-based diseases. Nowadays, commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID); glucocorticoids (SAID); and, in some cases, immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, and most of them are inadequate for chronic use. Starting from these premises, the demand for new, effective, and safe anti-inflammatory drugs has led research in new therapeutic directions. The recent and emerging scientific community slant is oriented towards natural products/compounds that could represent a boon for the discovery of new active molecules and for the development of new drugs and potentially useful therapeutic agents in different inflammatory-related diseases. We hope that it will stimulate the interest of the scientific community involved in studying the effects of natural and synthetic compounds in different fields of interest such as acute and chronic inflammation, inflammatory pain, inflammation-related diseases (e.g., autoimmune diseases), amongst others
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    Antimicrobial Prescribing and Stewardship, 1st Volume (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572550 , 9783036572543
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medicine
    Abstract: This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship;Diagnostic stewardship;Influence of antimicrobial utilisation changes in antimicrobial resistance;Impact of antimicrobial stewardship on quality performance measures and patient outcomes;Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers;Behavioural change approaches to antimicrobial stewardship;Collaborative practice agreements in antimicrobial stewardship;Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology);Tackling AMR through antimicrobial stewardship in low- and middle-income countries;Antimicrobial stewardship for animal health;Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals);Antimicrobial use and stewardship in the context of the COVID-19 pandemic;Global collaborations to tackle AMR through antimicrobial stewardship
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    Pathogenesis of Pregnancy-Related Complication (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573274 , 9783036573267
    Language: Undetermined
    Pages: 1 Online-Ressource (352 p.)
    Keywords: Medicine
    Abstract: In this Special Issue, "Pathogenesis of Pregnancy-Related Complications", 4 reviews, 13 original papers, 1 communication, and 1 case report are compiled. These papers were published by scientific teams from 24 countries, including China, Tunisia, Canada, France, Serbia, Portugal, Spain, Chile, Singapore, Australia, the USA, Mexico, the Czech Republic, Germany, Sweden, Finland, the United Kingdom, Norway, Poland, Greece, Japan, Italy, Switzerland, and Israel, which is a really great achievement
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  • 79
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    Human Biomonitoring in Health Risk Assessment : Current Practices and Recommendations for the Future (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570044 , 9783036570051
    Language: Undetermined
    Pages: 1 Online-Ressource (284 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support
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  • 80
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    Toxins : Mr Hyde or Dr Jekyll? (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569048 , 9783036569055
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolution to acquire/improve their disabling/lethal effects, they display finely tuned functional properties often associated with high affinities and selectivity. Moreover, toxins are valuable tools to unravel cellular processes due to their extreme specificity for cell surface and/or intracellular targets. Therefore, toxins are very attractive compounds because of their Janus-like character; while they mostly act as deadly poisons like monstrous Mr. Hyde, they can also be tamed into good remedies like admirable Dr. Jekyll. As such, they have been primarily investigated not only for the light they can throw on fundamental physiological processes but also for their potential therapeutic applications. This reprint, emerging from the 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet.asso.fr/international), will be of great interest for those in the scientific community who want to know more about the fascinating world of toxins
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  • 81
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    Diabetology: Feature Papers 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572567 , 9783036572574
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue “Diabetology: Feature Papers 2022” has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities
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  • 82
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    Biomechanics-Based Motion Analysis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036580272 , 9783036580265
    Language: Undetermined
    Pages: 1 Online-Ressource (386 p.)
    Keywords: Medicine
    Abstract: Collectively, the studies presented in this reprint have used various validated biomechanical models or proposed novel methods of motion analysis to gain new insights into health-related problems and sports performance
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  • 83
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    Marine Bioactive Peptides—Structure, Function, and Application (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036582603 , 9783036582610
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In recent years, peptides generated from various marine organisms have attracted wide attention due to their diverse chemical structures and bioactivities, including antioxidant, immune-modulating, angiotensin-I-converting enzyme (ACE)-inhibitory, hypotensive, hypolipidemic, antiviral, cytotoxic, neurotoxic, anticoagulant, antifreeze, etc. Moreover, bioactive peptides can serve as additional functional components used in health foods, nutraceuticals, bio-preservatives, cosmetics, and pharmaceuticals. The Special Issue on “Marine Bioactive Peptides—Structure, Function, and Application” aimed to collect papers on up-to-date information regarding the preparation, structural identification, activity and functional evaluation, and application of marine bioactive peptides
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  • 84
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    Heme Oxygenase (HO)-1 as an Immunoregulator in Health and Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036581361 , 9783036581378
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: Heme oxygenase (HO)-1 is a well-known, cytoprotective enzyme, responsible for the enzymatic conversion of heme into the anti-apoptotic and antioxidant by-products, biliverdin, bilirubin and carbon monoxide. However, HO-1 also regulates responses via mechanisms that are independent of the generation of heme degradation products. The current Special Issue contains research and review articles on the effect of heme oxygenase on immune-related cellular and physiological cascades and functions including effects on innate immunity, adaptive immunity, inflammation and complement activation. A description of the role of HO-1 in immune regulation directly or via its by-products is depicted on various forms of infection, viral and bacterial, immune-mediated injury such as renal injury, allergic airway inflammation, cancer and metabolism. Thus, the current Special Issue aims to serve as a detailed, analytical and up-to-date guide of the recent advances on the immunomodulatory properties of HO-1
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  • 85
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    New Insights into Endometrial Cancer 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579153 , 9783036579146
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine ; Oncology
    Abstract: This open access Special Issue brings together original research and review articles on molecular oncology, with attention given to endometrial cancer. It highlights new findings, methods, and technical advances in molecular cancer research. The main feature of this Special Issue is that it is a platform for open-source sharing of significant works in the field of molecular oncology that can increase our understanding of endometrial cancer development, which may lead to the discovery of new molecular diagnostic technologies and targeted therapeutics.Topics include:Molecular methods to personalize endometrial cancer screening and detection;Identification and new aspects of cellular signaling molecules and pathways for target discovery, drug design, and personalized and gender medicine;DDI discovery in endometrial cancer management;Drug repurposing for endometrial cancer prevention/treatment;Molecular modeling studies
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  • 86
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    Coronary Syndrome: Clinical Treatment, Prevention and Management for Better Outcomes (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579122 , 9783036579139
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes
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  • 87
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    HPV-Vaccines (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559179 , 9783036559186
    Language: Undetermined
    Pages: 1 Online-Ressource (214 p.)
    Keywords: Medicine
    Abstract: Human papillomavirus (HPV) is closely linked with the pathogenesis of cervical cancer and many other cancers. HPV vaccines are vaccines that prevent infection from certain types of human papillomavirus. However, despite the various prevention strategies and treatments, such as HPV screening, prophylactic HPV vaccines, surgery, radiotherapy, and chemotherapy, the disease burden remains heavy worldwide. Currently, three types of prophylactic vaccines—quadrivalent HPV vaccines, bivalent HPV vaccines, and a new nonavalent HPV vaccine—are commercially available. Although these vaccines protect against 90% of HPV infections, their capacity to eliminate pre-existing infections is limited. In this Topical Collection, we aim to systematically cover the progress, current status, and future prospects of various vaccines being developed for the prevention and treatment of HPV-associated lesions and cancers
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  • 88
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    Young-Onset GI Cancer (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579641 , 9783036579658
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medicine ; Oncology
    Abstract: In the last decade, the incidence of cancer in young patients has increased in several cancer types according to the US Surveillance, Epidemiology and End Result (SEER) data and other worldwide registries. Recently, Sung and colleagues published an extensive pooled analysis from the US in Lancet Public Health, which revealed a dramatic increase in cancer incidence among younger adults (aged 25–49 years), mainly in “obesity-related” cancers, most of which occur in the gastrointestinal (GI) tract. Several studies over the past decade have indicated a significant increase in colorectal cancer incidence among young adults below the age of 50 years. Current evidence suggests that the majority of early-onset GI cancers are sporadic and harbor no familial etiology, indicating the potentially significant role of environmental and behavioral factors in their pathogenesis. Furthermore, the gut microbiome has been proposed to play a key role in CRC carcinogenesis. The scope of this Special Issue of Cancers is to highlight perspectives regarding biology, etiology, late-term toxicities and quality of life which are unique and relevant to young-onset GI cancer cases
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  • 89
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    Nuts: Where We Are and Where We Are Going in Research. Proceedings from the NUTS 2022 International Conference (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036578866 , 9783036578873
    Language: Undetermined
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Humans have eaten nuts for thousands of years, yet their consumption was discouraged just a few decades ago due to their high-fat content. This perspective began to change in the early 1990s due to seminal publications from the Adventist Health Study, which showed that nut consumption significantly improved heart health-related outcomes. Many randomized clinical trials, epidemiological studies, and in vitro/in vivo mechanistic studies have since explored the role of eating nuts and its relation to health. Similarly, dried fruits have been scrutinized due to their concentrated sugar content despite their non-sodium micronutrient and fiber density. Due to accumulating evidence on nut and dried fruit intake and health outcomes, an international scientific meeting was organized for leading experts to examine and recapitulate in detail what is well known and established and what avenues of knowledge are still lacking in nut and dried fruit research. These findings highlight the beneficial health potentials of nuts for researchers, health professionals, other stakeholders, and the public while simultaneously pinpointing areas for further investigation to continue informing and guiding health practices and policies
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  • 90
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    The Identification of Drug Abuse (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579665 , 9783036579672
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Over the last decades, interest in forensic toxicology has continually increased. Consequently, the discipline assumed a leading role, becoming one of the reference sciences for elucidating events of judicial importance. The need to reconcile analytical problems (e.g., relating to the qualitative/quantitative analysis of substances of abuse in complex biological matrices) with judicial requirements (i.e., providing data that can be used as documentary evidence in proceedings) makes the discipline unique among all "analytical" sciences. Thus, the availability of validated procedures, the constant monitoring of analytical performance through quality assurance protocols, the availability of certified “in matrix” standards, and the analytical problems underlying the analysis of new psychoactive substances in the blood and other biological fluids represent the challenges of modern forensic toxicology. The correct interpretation of analytical data, especially to elucidate the extent of impairment induced by a certain substance, and “old” issues related to the correct interpretation of post-mortem data (given the impossibility of translating the therapeutic ranges defined in vivo) represent further areas of research and debate among scientists. Finally, the possibility of interacting with other disciplines (such as proteomics and social sciences) allows for extending the concept of analytical data acquisition/interpretation beyond the classical limits of forensic toxicology (for example, considering the influence of gender when interpreting the effect of a substance)
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  • 91
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    Diagnosis of Lower Genital Tract Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592978 , 9783036592961
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine
    Abstract: Lower genital tract diseases include vulvovaginal and HPV-related diseases, ranging from benign to pre-neoplastic and neoplastic lesions. Nowadays, there has been increasing interest in innovative methods to diagnose and prevent cervical cancer through HPV primary screening programs. However, other lower genital tract diseases are unrelated to HPV infection; hence, cytology, colposcopy, and sonography might play a crucial role in assessment and management. This Special Issue aims to address current and emerging issues in the field of the diagnosis, assessment, staging, and management of HPV-related and not-related pathology of the lower female anogenital tract. These may include new advancements in HPV testing and laboratory biomarkers, investigations on the actual role of cytology and implementation of diagnostic tools to implement differential diagnosis, and the current clinical management of lower genital tract diseases
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  • 92
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    Sports or/and Special Populations: Training Physiology in Health and Sports Performance (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590530 , 9783036590523
    Language: Undetermined
    Pages: 1 Online-Ressource (306 p.)
    Keywords: Medicine ; Physiology
    Abstract: Several factors have been identified as interfering with the success, rehabilitation, and fitness of athletes from childhood to adulthood, as well as in para-sport, and special populations, according to research. The performance and health of this population are affected by the relationships between stress, maturation, training load, and recovery. Environmental approaches aim to increase efficiency and physiological adaptations in this sense. In various situations and conditions, however, this stimulus–performance–adaptation relationship varies.As a result, we received contributions related (but not limited) to the following topics: training load monitoring; stress and physiological responses during exercise or sports; recovery process after exercise; changes after stress and/or training load; physiology of training in health and sports performance
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  • 93
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    Advances in Parvovirus Research 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594484 , 9783036594491
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Viruses in the Parvoviridae family constitutes a most diverse and intriguing field of research. Parvoviruses have a long evolutionary history and, beneath an apparent simplicity and uniformity, can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. In addition to interest in the study of basic virology, the translational implications of research on parvoviruses are relevant since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and the inherent complexity in the biology of these apparently simple viruses is an ongoing commitment for the scientific community to address. This Special Issue entitled ‘Advances in Parvovirus Research 2022’ continued the series dedicated to research on viruses belonging to the Parvoviridae family and collected the latest contributions in the field of parvovirus research
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  • 94
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    Computer Aided Diagnosis Sensors (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036595320 , 9783036595337
    Language: Undetermined
    Pages: 1 Online-Ressource (670 p.)
    Keywords: Medicine
    Abstract: Sensors used to diagnose, monitor or treat diseases in the medical domain are known as medical sensors. There are several types of medical sensors that can be utilized for various applications, such as temperature probes, force sensors, pressure sensors, oximeters, electrocardiogram sensors that measure the electrical activity of the heart, heart rate sensors, electroencephalogram sensors that measure the electrical activity of the brain, electromyogram sensors that record electrical activity produced by skeletal muscles, and respiration rate sensors that count how many times the chest rises in a minute. The output of these sensors used to be interpreted by humans, which was time consuming and tedious; however, such interpretations became easy with advances in artificial intelligence (AI) techniques and the integration of the sensor outputs into computer-aided diagnostic (CAD) systems. This reprint presents some of the state-of-the-art AI approaches that are used to diagnose different diseases and disorders based on the data collected from different medical sensors. The ultimate goal is to develop comprehensive and automated computer-aided diagnosis by focusing on the different machine learning algorithms that can be used for this purpose as well as novel applications in the medical field
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  • 95
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    Advances in Postoperative Pain Management and Chronic Postoperative Pain (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592725 , 9783036592732
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies
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  • 96
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    Clinical Research on Type 2 Diabetes and Its Complications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594187 , 9783036594194
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine
    Abstract: The huge prevalence of type 2 diabetes is a leading human and economic concern worldwide. The diagnosis code of type 2 diabetes includes multiple clinical phenotypes showing different degrees of obesity, fat distribution patterns, types of dyslipidemia, and characteristics of insulin resistance syndrome. In addition, subjects with type 2 diabetes could develop different clinical trajectories, with age being a critical factor in progression. The chronic complications of type 2 diabetes are a major cause of mortality and disability, and are ranked in the top places in western countries’ scores. The pathophysiological heterogeneity of type 2 diabetes is not captured by the current classifications and guidelines. The potential for diabetes progression and complications developing is different depending on the type 2 diabetes cluster, which is mostly regardless of the degree of glycemic control. However, the impact on quality and life expectancy with the current therapeutic approach is not always the same for every individual. Clinical research is the key to reducing the burden of diabetes. New basic, digital, and clinical approaches are obtaining useful knowledge and designing more individualized interventions to prevent, track, and treat diabetic complications. This Special Issue is a clear reflection of this methodological evolution
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  • 97
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    Clinical Pharmacology and Pharmacy of Antimicrobial Agents (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591094 , 9783036591087
    Language: Undetermined
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In this Special Issue, our aim was to collect studies on clinical pharmacology and pharmacy of antimicrobial agents from both human and veterinary medicine as the complex problem of AMR requires actions taken within the One Health approach that involve both fields. Studies covered here are about new or optimized usage of already authorized antimicrobials, as well as discoveries about new agents, new combinations of drugs, and drug repositioning. Pharmacodynamic, pharmacokinetic, and toxicological aspects of individual and combinational drug use are areas covered in this Special Issue
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  • 98
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    Pediatric Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590240 , 9783036590257
    Language: Undetermined
    Pages: 1 Online-Ressource (456 p.)
    Keywords: Medicine ; Oncology
    Abstract: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies
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  • 99
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    New Insights into Pediatric Pulmonology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593623 , 9783036593630
    Language: Undetermined
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Medicine
    Abstract: Children with pulmonology issues have always introduced challenges for pediatricians. This Special Issue provides a platform for researchers and clinicians to discuss the novel methods of functional assessment, new insights into exercise physiology, the effect of maturation and puberty on pulmonary parameters, the translational aspects of overweight and obesity, the evaluation of active rehabilitation in pediatric pulmonology, long-term and post-COVID-19 illnesses, the pediatric origin of adult diseases, etc
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  • 100
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    Advance in Orthopedic Trauma Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591766 , 9783036591773
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: The field of orthopedic trauma has always been a discipline cahacterized by rapid innovation and creative evolution. We see evolution in every facet of orthopedic surgery, ranging from the transformation of the understanding of implant design and biomechanics to the understanding and monitoring of fracture healing and the management of complications. This Reprint includes many articles discussing topics, such as distal radius fractures, hip fractures, osteoarthritis, ankle fractures, acetabular fractures, and anterior cruciate ligament reconstruction
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