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  • English  (52)
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  • [Erscheinungsort nicht ermittelbar] : IntechOpen  (52)
  • Wiesbaden : Harrassowitz
  • Immunology  (52)
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  • 1
    Online Resource
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789238884 , 9781789238877 , 9781789851410
    Language: English
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Immunology
    Abstract: This book is a collection of chapters that discuss methodologies, resources, and technologies by dedicated authors. This book has addressed the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. All chapters have focused on the fate of differentiated macrophages and discussed molecular pathways that are important for the pathologic role of macrophages. I am confident that our readers will find this book useful in designing immune mediated strategies for managing various diseases that this book is based on
    Note: English
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  • 2
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839625367 , 9781839625350 , 9781839625374
    Language: English
    Pages: 1 Online-Ressource (92 p.)
    Keywords: Immunology
    Abstract: Celiac disease is a common autoimmune disorder triggered by eating gluten that affects at least 1% of the world's population. Despite many years of effort, its pathogenesis is still not understood completely. This book discusses several important aspects of celiac disease, including its primary contributor, the DQ2 gene. It also examines dysfunctional immune checkpoints, causes and treatments of refractory celiac disease, and the status of the gluten-free food market
    Note: English
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  • 3
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789855845 , 9781789855838 , 9781838804305
    Language: English
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Immunology
    Abstract: The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness
    Note: English
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  • 4
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839681240 , 9781839681233 , 9781839681257
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Keywords: Immunology
    Abstract: Our immune system is equipped with a series of defence mechanisms to recognise and respond to non-self molecules. Although essential for fighting off infections and preventing cancers, destructive immune responses pose a considerable challenge in autoinflammation and transplantation. Currently available immunosuppressants help to control destructive immune responses. However, management of side-effects of lifelong immunosuppression, including cancer development and reduced survival, remain major problems. For this reason, an increasing amount of interest is directed towards the natural specific regulatory mechanism of the immune system. A better understanding of these mechanisms holds the key. This book presents a comprehensive overview of immune suppression in transplantation, cancer and viral infections. Chapters cover modulation of Treg as well as the new era of immunotherapy
    Note: English
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  • 5
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789846454 , 9781789846447 , 9781789855746
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Keywords: Immunology
    Abstract: Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields
    Note: English
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  • 6
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781838801700 , 9781838801694 , 9781838801847
    Language: English
    Pages: 1 Online-Ressource (138 p.)
    Keywords: Immunology
    Abstract: Systemic lupus erythematosus, the prototype of an autoimmune disorder, may affect several organs and may run a chronic course between relapse and remission. This book covers important aspects of the disease, including epidemiology, pathophysiology, and neuropsychiatric manifestations, including basic science and clinical features and management. In affected patients, the fundamental problem of fertility is reassessed including the risk of the disease, the possibility of fetal loss, the safety of drugs during pregnancy, and the current diagnostic and suggested therapeutic strategies of reproductive medicine. Finally, the issue of pathogenesis is revisited with a thorough description of animal models in relation to physiology and potential novel therapies
    Note: English
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  • 7
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839625336 , 9781839625329 , 9781839625343
    Language: English
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Immunology
    Abstract: Rheumatoid Arthritis - Other Perspectives towards Better Practice sheds light on the disease process of rheumatoid arthritis as well as the disease’s related comorbidities. Chapters cover such topics as immune-pathogenic theories, classification criteria, available composite measures of disease assessment, and latest available therapeutic approaches
    Note: English
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  • 8
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789848595 , 9781789848588 , 9781839683398
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Immunology
    Abstract: The human immune system is a complicated biological network that employs a collection of cells, molecules, and proteins. Cytokines play an important role in regulating the innate and adaptive immune systems by different receptors and signaling pathways. As such, they are also implicated in the occurrence of different disorders and diseases. This book presents a comprehensive overview of immunology, the immune system, and cytokines. Chapters cover such topics as the role and importance of tumor necrosis factor (TNF) in the human body, the association of cytokines with different disorders and diseases, and the role of cytokines in dentistry
    Note: English
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  • 9
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789843583 , 9781789843576 , 9781839680014
    Language: English
    Pages: 1 Online-Ressource (248 p.)
    Keywords: Immunology
    Abstract: Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental models, the chapters selected for this book bring to readers at different academic levels updated and practical data on inflammation. Find out what drives interdisciplinary medical research on inflammation and enjoy this informative collection
    Note: English
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  • 10
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781839628337 , 9781838810351 , 9781839628344
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Immunology
    Abstract: Sarcoidosis is a multi-organ, granulomatous disease the etiology of which remains unknown. It is characterized by T-cell dysfunction and B-cell hyperactivity with increased local immune activity and inflammation that leads to the formation of noncaseating granulomas in the organs involved. The lung and lymphatic system are the most commonly affected organs, however virtually any organ may be affected. Other common sites of involvement include the skin, eye, central nervous system, and the heart. Patients may present different symptoms related to the disease stage and the specific organ involved. Sarcoidosis is a global disease, and its prevalence has increased twofold over the past years. Due to the clinical heterogeneity and variable diagnostic criteria in different countries, it is difficult to calculate the exact prevalence and incidence of sarcoidosis. Age, sex, race, and geographic origin significantly influence the incidence of sarcoidosis. The book at hand seeks to assess the current diagnostic techniques, imaging techniques, differential diagnosis of this disease, as well as other granulomatous diseases mimicking sarcoidosis
    Note: English
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  • 11
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789857627 , 9781789857610 , 9781839620782
    Language: English
    Pages: 1 Online-Ressource (68 p.)
    Keywords: Immunology
    Abstract: This book is a concise review of medically important applications of Human Leukocyte Antigen (HLA) in medicine. It covers both basic knowledge of HLA and its main clinical applications in medical practice. Its two major aims are to assist students who are preparing for clinical immunology examinations, and to help people who want to understand more about this subject with brief and flexible sources of information. This book presents current, medically important information on the rapidly changing field of tissue typing and its relation with diseases. It includes updated information on such topics as tissue typing in medicine and transplant immunology
    Note: English
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  • 12
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789239027 , 9781789239010 , 9781838814823
    Language: English
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Immunology
    Abstract: Rapid tests, also known as point-of-care tests, have been in use for decades in the clinical and medical area and have become increasingly popular as an efficient screening method for conducting on-site analysis thanks to their simplicity, speed, specificity and sensitivity. Nowadays, rapid tests are widely applied for clinical, drug, food, forensic and environmental analysis and fields of application are rapidly increasing together with advances in the technology. The growing interest in rapid tests and their expanding application in diverse fields, together with requirements of improved sensitivity, reliability, multiple detection capacity and robustness, are prompting innovation in the design of novel platforms, and in the exploitation of innovative detection strategies. The book covers advances in materials, technology and test design
    Note: English
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  • 13
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535124429 , 9789535124412 , 9789535172833
    Language: English
    Pages: 1 Online-Ressource (254 p.)
    Keywords: Immunology
    Abstract: The clinical specificities developed in this book, particularly from those reported in the pediatric population to those reported in complex shapes at ACOS patients, emphasize the importance of identifying not only biomarkers but also critical aspects regarding the variability in pharmacogenomics responsible for the individual response to the different drugs on the therapeutic plan. The contribution of several well-known specialists with their profound knowledge inherent to this issue into different age groups and socio geographical contexts has resulted in this interesting book with relevant key contents in asthma
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  • 14
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535120278 , 9789535172314
    Language: English
    Pages: 1 Online-Ressource (176 p.)
    Keywords: Immunology
    Abstract: A balanced regulation of bone formation and resorption in the healthy individual is required for a healthy bone. On the other side, there are many factors which can lead to alterations in bone density and microarchitecture. Menopause is a condition which can increase the remodeling process in favor of resorption. Moreover, there are also some diseases, i.e. chronic kidney bone disease, that increase the possibility of fractures and the subsequent disability leading to increased mortality. However, it is clear that drugs are an essential element of the therapy and this issue is analyzed extensively in this book. Some novel pathophysiological mechanisms are also presented, offering advanced knowledge to the reader. The book includes chapters from scientific departments and researchers from all over the world
    Note: English
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  • 15
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535120445 , 9789535172383
    Language: English
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Immunology
    Abstract: Allergic diseases are one of the most prevalent diseases in the present with an undeniable correlation with development conditions and with the surrounding environment. Thus, it becomes imperative that the gradual understanding of the pathophysiology and treatment strategies may be convenient for wide dissemination in the scientific community. The chapters included in the book Allergic diseases New Insights addressed a variety of important topics related to distinct aspects related to allergy. The contribution of outstanding expert authors from many countries provided update reviews on basic, clinical and treatment aspects and put in evidence further research regarding the knowledge of immune system responses and key points of allergic inflammatory reactions
    Note: English
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  • 16
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535122104 , 9789535172666
    Language: English
    Pages: 1 Online-Ressource (312 p.)
    Keywords: Immunology
    Abstract: This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors
    Note: English
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  • 17
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    ISBN: 9789535121343 , 9789535172413
    Language: English
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Immunology
    Abstract: Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies
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  • 18
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535121367 , 9789535172437
    Language: English
    Pages: 1 Online-Ressource (274 p.)
    Keywords: Immunology
    Abstract: The most common form of arthritis is osteoarthritis (OA), which most often affects the hip, knee, foot and hand. The degeneration of joint cartilage and changes in underlying bone and supporting tissues such as ligament leads to pain, stiffness, movement problems and activity limitations. This book, containing three major sections in OA research and therapy, is an update of the book Osteoarthritis - Diagnosis, Treatment and Surgery published by InTech in 2012. The authors are experts in the osteoarthritis field, which include biologists, bioengineers, clinicians, and health professionals. The scientific content of the book will be beneficial to patients, students, researchers, educators, physicians, and health care providers who are interested in the recent progress in osteoarthritis research and therapy
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  • 19
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    ISBN: 9789535113744 , 9789535153948
    Language: English
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Immunology
    Abstract: The book Immune Response Activation is aiming to analyse the multifaceted aspects of the immune response, treating a number of representative cases in which the immune response is, on one hand, activated against pathogens, and, on the other hand, involved in pathologic settings, leading to allograft rejection, allergy and autoimmunity. The regulatory mechanisms in which the immune response can be modulated for rendering its effector components more efficient and/or not harmful to the organism is also dissected in translational purposes in cancer immunotherapy, local immunity against bacteria and viruses, as well as in allergy and autoimmunity
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  • 20
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    ISBN: 9789535112303 , 9789535171966
    Language: English
    Pages: 1 Online-Ressource (384 p.)
    Keywords: Immunology
    Abstract: This year marks the 60th anniversary of HLA discovery by the French Nobel laureate physician Jean Dausset, as well as the 55th anniversary of the identification and naming of the first HLA. Under such circumstances, both basic HLA research and its clinical applications need a new book that comprehensively reflects the latest achievements in the field. Thus, Professor Xi as Editor has contributed to organize international experts in the areas of HLA-related basic research and clinical applications, to unite their knowledge in chapters covering various related topics, and finally to finish the book "HLA and Associated Important Diseases". The book consists of three sections which mainly include basic theoretical and technological developments, several important HLA-associated autoimmune diseases and HLA-associated infectious diseases
    Note: English
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  • 21
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535110668 , 9789535171454
    Language: English
    Pages: 1 Online-Ressource (290 p.)
    Keywords: Immunology
    Abstract: Osteoporosis affects the osteo-articular system. However, there are hormonal, kidney related, gastrointestinal and neuromuscular factors among other, that can be involved in the etiopathogenesis of the disease. In the other hand, for osteoporosis prevention there are many lifestyle conditions that are very important, as dietary habits, physical activity, drugs and caffeine intake, smoking, associated diseases, etc. Based on the above, treatment and prevention of osteoporosis have to be addressed in a multidisciplinary and integral approach. The knowledge about bone metabolism and the related disorders represents an extensive field that is currently increasing through many investigations conducted in the world. The purpose of this book is to show several reviews and original investigations related with osteoporosis
    Note: English
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  • 22
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    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535109167 , 9789535170563
    Language: English
    Pages: 1 Online-Ressource (318 p.)
    Keywords: Immunology
    Abstract: In recent years, the treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is now possible, and the quality of life of patients with rheumatoid arthritis in long-term has been able to improve by advances in treatment. However, there are still many problems to be overcome before achieving the treatment of rheumatoid arthritis. All of review articles presented on this book are explaining treatment, basic research, and patient care of rheumatoid arthritis with innovative perspective and ideas. I hope that the ideas that have been described in these articles help the reader to resolve the outstanding issues in rheumatoid arthritis
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  • 23
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    ISBN: 9789535110118 , 9789535171010
    Language: English
    Pages: 1 Online-Ressource (262 p.)
    Keywords: Immunology
    Abstract: This book collects the state of the art of the antioxidants from the clinical and experimental approaches in order to bring a better understanding of the mechanisms and useful therapies for these diseases. We hope that it can indicate new "current trends" for identifying new aspects regarding this scientific problem involving not only anatomical and functional, but also clinical questions
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  • 24
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    ISBN: 9789535110088 , 9789535170983
    Language: English
    Pages: 1 Online-Ressource (284 p.)
    Keywords: Immunology
    Abstract: Vasculitis, an inflammation of blood vessels, can be idiopathic or secondary to other conditions. Infections may also mimic idiopathic vasculitis, and the differential diagnosis is of paramount importance for the practicing physician. Vasculitides are not rare diseases. In fact, some vasculitides, such as giant cell arteritis, cutaneous vasculitis, and ANCA-associated vasculitis are relatively common in everyday practice. Vasculitis may rapidly lead to organ failure, and put patient's life in danger. Therefore, physicians of different specialties should diagnose vasculitis early, because early institution of treatment is crucial for the favorable outcome. In recent years progress has been made in the pathophysiology and treatment of vasculitis. This book reflects all new advances in pathogenetic mechanisms, diagnosis, and treatment of different types of vasculitis. The international panel of authors helps in achieving a balanced view on different aspects of vasculitis
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  • 25
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    ISBN: 9789535111856 , 9789535171768
    Language: English
    Pages: 1 Online-Ressource (190 p.)
    Keywords: Immunology
    Abstract: The magnitude and rapidity of the changes in the concentrations of APPs, together with their short half-life, suggest an important role for these proteins in the establishment of host defense. APPs are regarded as having general functions in trapping of micro-organisms and their products, in activating complement, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free radicals, and in modulating the hosts immune response. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their function during health and disease remains incompletely defined
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  • 26
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    ISBN: 9789535100263 , 9789535168065
    Language: English
    Pages: 1 Online-Ressource (878 p.)
    Keywords: Immunology
    Abstract: Osteoporosis is a public health issue worldwide. During the last few years, progress has been made concerning the knowledge of the pathophysiological mechanism of the disease. Sophisticated technologies have added important information in bone mineral density measurements and, additionally, geometrical and mechanical properties of bone. New bone indices have been developed from biochemical and hormonal measurements in order to investigate bone metabolism. Although it is clear that drugs are an essential element of the therapy, beyond medication there are other interventions in the management of the disease. Prevention of osteoporosis starts in young ages and continues during aging in order to prevent fractures associated with impaired quality of life, physical decline, mortality, and high cost for the health system. A number of different specialties are holding the scientific knowledge in osteoporosis. For this reason, we have collected papers from scientific departments all over the world for this book. The book includes up-to-date information about basics of bones, epidemiological data, diagnosis and assessment of osteoporosis, secondary osteoporosis, pediatric issues, prevention and treatment strategies, and research papers from osteoporotic fields
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  • 27
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    ISBN: 9789535105893 , 9789535152934
    Language: English
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Immunology
    Abstract: This book presents some recent researches related to histocompatibility for scientists interested in this field. It includes 10 chapters, in different topics, prepared by Sundararajulu Panneerchelvam and Mohd Nor Norazmi; Giada Amodio and Silvia Gregori; Adema Ribic; Bahaa K. A. Abdel-Salam; Kai-Fu Tang; Roberto Biassoni, Irene Vanni and Elisabetta Ugolotti; Wei-Cheng Yang, Lien-Siang Chou and Jer-Ming Hu; Shatrah Othman and Rohana Yusof; Masahiro Hirayama, Eiichi Azuma and Yoshihiro Komada; Gustav Roder, Linda Geironson, Elna Follin, Camilla Thuring and Kajsa Paulsson
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  • 28
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    ISBN: 9789535102274 , 9789535168720
    Language: English
    Pages: 1 Online-Ressource (568 p.)
    Keywords: Immunology
    Abstract: The present Edition "Allergic diseases - highlights in the clinic, mechanisms and treatment" aims to present some recent aspects related to one of the most prevalent daily clinical expression disease. The effort of a group of outstanding experts from many countries reflects a set of scientific studies very promising for a better clinical care and also to the treatment and control of the allergy. This book provides a valuable reference text in several topics of the clinical allergy and basic issues related to the immune system response. The inflammatory reaction understanding in allergic disease is clearly evidenced, as well as new strategies for further researches
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  • 29
    ISBN: 9789535100638 , 9789535168225
    Language: English
    Pages: 1 Online-Ressource (604 p.)
    Keywords: Immunology
    Abstract: This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray
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  • 30
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    ISBN: 9789533078694 , 9789535167372
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Immunology
    Abstract: Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting
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  • 31
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    ISBN: 9789533078502 , 9789535167204
    Language: English
    Pages: 1 Online-Ressource (378 p.)
    Keywords: Immunology
    Abstract: The purpose of this book is to provide up-to-date, interesting, and thought-provoking perspectives on various aspects of research into current and potential treatments for rheumatoid arthritis (RA). This book features 17 chapters, with contributions from numerous countries (e.g. UK, USA, Canada, Japan, Sweden, Turkey, Bosnia and Herzegovina, Slovakia), including chapters from internationally recognized leaders in rheumatology research. It is anticipated that Rheumatoid Arthritis - Treatment will provide both a useful reference and source of potential areas of investigation for research scientists working in the field of RA and other inflammatory arthropathies
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  • 32
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    ISBN: 9789535102885 , 9789535168997
    Language: English
    Pages: 1 Online-Ressource (228 p.)
    Keywords: Immunology
    Abstract: Allergic rhinitis, while troublesome for a patient, may be also a challenge for the physician. That is why physicians must still learn more on the pathophysiology, clinical spectrum and novel diagnostic and therapeutic approaches to the disease. The chapters of this volume address a variety of important topics related to allergic rhinitis. They begin with a description of innovative translational approaches allowing for unification of animal and human models. Contributing authors provide up-to-date reviews of clinical aspects of allergic rhinitis in children, its association with bronchial asthma and other co-morbid conditions. They also discuss the impact of allergic rhinitis on sleep and sports. Together with articles on diagnostic approaches as well as novel treatments, the book offers a comprehensive and stimulating review of the topic. May this book find a wide readership among allergists and other physicians interested in allergic disease, and also among pediatricians, general practitioners and other specialists who increasingly have to deal with this seemingly benign, but sometimes extremely troublesome, disease
    Note: English
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  • 33
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    ISBN: 9789533078472 , 9789535167174
    Language: English
    Pages: 1 Online-Ressource (316 p.)
    Keywords: Immunology
    Abstract: The purpose of this book is to provide up-to-date, interesting, and thought-provoking perspectives on various aspects of research into current and potential treatments for rheumatoid arthritis (RA). This book features 16 chapters, with contributions from numerous countries (e.g. UK, USA, Japan, Sweden, Spain, Ireland, Poland, Norway), including chapters from internationally recognized leaders in rheumatology research. It is anticipated that Rheumatoid Arthritis - Etiology, Consequences and Co-Morbidities will provide both a useful reference and source of potential areas of investigation for research scientists working in the field of RA and other inflammatory arthropathies
    Note: English
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  • 34
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    ISBN: 9789533079110 , 9789535167600
    Language: English
    Pages: 1 Online-Ressource (410 p.)
    Keywords: Immunology
    Abstract: This book is a collection of comprehensive reviews contributed by experts in the diverse fields of acute and chronic inflammatory diseases, with emphasis on current pharmacological and diagnostic options. Interested professionals are also encouraged to review the contributions made by experts in a second related book entitled "Inflammation, Chronic Diseases and Cancer"; it deals with immunobiology, clinical reviews, and perspectives of the mechanisms of immune inflammatory responses that are involved in alterations of immune dynamics during the genesis, progression and manifestation of a number of inflammatory diseases and cancers, as well as perspectives for diagnosis, and treatment or prevention of these disabling and potentially preventable diseases, particularly for the growing population of older adults around the globe
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  • 35
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    ISBN: 9789533078212 , 9789535167020
    Language: English
    Pages: 1 Online-Ressource (116 p.)
    Keywords: Immunology
    Abstract: Myasthenia gravis is presently an incurable antibody-mediated autoimmune disorder characterized by generalized voluntary skeletal muscle weakness. The cause of the weakness is a defect at the neuromuscular junction level, in which autoimmune antibodies block the receptors responsible for initiating muscular contraction. Literally translated from its Latin and Greek etymological roots, myasthenia gravis means "grave muscle weakness". Fortunately, advances in modern medicine have resulted in a reduction of the truly "grave" outcomes for those inflicted but, without a cure, the gravity surrounding the disease remains
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  • 36
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    ISBN: 9789535101376 , 9789535168409
    Language: English
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Immunology
    Abstract: The first section of the book entitled Clinical and Molecular Advances in Ankylosing Spondylitis is a review of the clinical manifestations of Ankylosing Spondylitis (AS) and Spondyloarthritis (SpA). The book includes chapters on Bone Mineral Density measurements, two chapters on the temporomandibular joints, axial fractures, clinical manifestations, diagnosis, and treatment. Molecular genetics and immune response are analyzed in the second section of the book; information on HLA-B*27, other MHC genes and the immune response of AS patients to bacteria is reviewed and updated. Two chapters are dedicated to recent information on non-MHC genes in AS susceptibility, and to new data on disease pathways generated from gene expression studies on peripheral blood
    Note: English
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  • 37
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    ISBN: 9789535103707 , 9789535152514
    Language: English
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Immunology
    Abstract: This book explains the concept of serological methods used in laboratory diagnoses of certain bacteria, mycoplasmas, viruses in humans, animals and plants, certain parasitic agents as well as autoimmune disease. The authors present up-to-date information concerning the serological methods in laboratory diagnosis of such infectious diseases. Section one deals with the serological methods for bacteria. Section 2 deals with serological methods in human, animal and plant viruses. Section 3 is concerned with the serological laboratory diagnosis of echinococcus and human toxocariasis agents. The last section deals with serological laboratory methods in the diagnosis of coeliac disease
    Note: English
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  • 38
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    ISBN: 9789535105923 , 9789535169901
    Language: English
    Pages: 1 Online-Ressource (534 p.)
    Keywords: Immunology
    Abstract: Immunology is the branch of biomedical sciences to study of the immune system physiology both in healthy and diseased states. Some aspects of autoimmunity draws our attention to the fact that it is not always associated with pathology. For instance, autoimmune reactions are highly useful in clearing off the excess, unwanted or aged tissues from the body. Also, generation of autoimmunity occurs after the exposure to the non-self antigen that is structurally similar to the self, aided by the stimulatory molecules like the cytokines. Thus, a narrow margin differentiates immunity from auto-immunity as already discussed. Hence, finding answers for how the physiologic immunity turns to pathologic autoimmunity always remains a question of intense interest. However, this margin could be cut down only if the physiology of the immune system is better understood. The individual chapters included in this book will cover all the possible aspects of immunology and pathologies associated with it. The authors have taken strenuous effort in elaborating the concepts that are lucid and will be of reader's interest
    Note: English
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  • 39
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    ISBN: 9789533078465 , 9789535167167
    Language: English
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Immunology
    Abstract: This book offers a range of perspectives on pathogenesis, clinical features and treatment of different rheumatic diseases, with a particular focus on some of the interesting aspects of Sjögren's syndrome. It contains detailed and thorough reviews by international experts, with a diverse range of academic backgrounds. It will also serve as a useful source of information for anyone with a passive interest in rheumatology, from the genetic and molecular level, through to the psychological impact of pain and disability
    Note: English
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  • 40
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    ISBN: 9789535108603 , 9789535170419
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Immunology
    Abstract: The present edition of "Current Insights in Pollen Allergens" provides recent aspects related to pollen allergy, a major medical problem which is still under thorough studies. The chapters of this book will be of significant value to those interested to get notions about molecular basis of pollen allergy, such as allergen proteins polymorphism and its implications in allergic disease, cross-reactivity between pollen and pollen-plant food derived allergens, as well as strategies for clinical trial and future research. This book also provides insights about the application of molecular tools in allergens detection and quantification such as "multiplex methods", helping in the development of the standardization process of pollen protein extracts, ensuring efficiency and safety in allergy diagnosis and immunotherapy, but also exploring factors that affect allergen product expression (environmental factors), and alternative effective anti-allergic and/or preventative strategies for allergic diseases
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  • 41
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    ISBN: 9789535107910 , 9789535153269
    Language: English
    Pages: 1 Online-Ressource (404 p.)
    Keywords: Immunology
    Abstract: This book reflects a major medical problem which is still under thorough studies. There is a number of clinical cases corresponding directly or indirectly to a certain alteration of the immune system, thus leading to various pathologic conditions. The unique defense, what humans have with their immunity, is rather often affected by infections, tumor processes, organ, tissue and cell transplantation, allergy, autoimmune processes, as well as different influences by the environment. The Book has an international team of authors all contributing to the investigation of the questions of what, why, how, when and where the immune system deviates from its normal function, what clinical consequences are manifested and is there a way to prevent and treat the immunodeficiency cases. This Book can be a very good teaching tool for students and post-docs of medicine and biology, but it also provides updated information for the colleagues immunologists, microbiologists, virologists, chemotherapists, oncologists, hematologists, transplantologists and pathologist
    Note: English
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  • 42
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    ISBN: 9789535105268 , 9789535169703
    Language: English
    Pages: 1 Online-Ressource (244 p.)
    Keywords: Immunology
    Abstract: The antiphospholipid syndrome has been described for the first time by Graham Hughes in 1983 as a condition connected with thromboses or foetal losses and antiphospholipid antibodies presence. Form that time there has been a great progress in knowledge, including antiphospholipid antibodies characterisation, their probable and also possible action, clinical manifestations, laboratory detection and treatment possibilities . This book provides a wide spectrum of clinical manifestations through Chapters written by well known researchers and clinicians with a great practical experience in management of diagnostics or treatment of antiphospholipid antibodies' presence
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  • 43
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    ISBN: 9789535101680 , 9789535168546
    Language: English
    Pages: 1 Online-Ressource (418 p.)
    Keywords: Immunology
    Abstract: Osteoarthritis is one of the most debilitating diseases affecting millions of people worldwide. However, there is no FDA approved disease modifying drug specifically for OA. Surgery remains an effective last resort to restore the function of the joints. As the aging populations increase worldwide, the number of OA patients increases dramatically in recent years and is expected to increase in many years to come. This is a book that summarizes recent advance in OA diagnosis, treatment, and surgery. It includes wide ranging topics from the cutting edge gene therapy to alternative medicine. Such multifaceted approaches are necessary to develop novel and effective therapy to cure OA in the future. In this book, different surgical methods are described to restore the function of the joints. In addition, various treatment options are presented, mainly to reduce the pain and enhance the life quality of the OA patients
    Note: English
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  • 44
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    ISBN: 9789535103998 , 9789535169314
    Language: English
    Pages: 1 Online-Ressource (190 p.)
    Keywords: Immunology
    Abstract: If you want to learn more about osteomyelitis you should not miss this book. The editors are professionals and scientists working in health sciences and the chapters have been prepared by experts in the field, covering subjects related with the fundamentals of osteomyelitis and new diagnosis and treatment tools. You will have the opportunity to review concepts as well as to learn state-of-the-art alternatives for diagnosis and treatments
    Note: English
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  • 45
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    ISBN: 9789535104407 , 9789535152576
    Language: English
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Immunology
    Abstract: From the basic in vitro study of a specific biomolecule to the diagnosis or prognosis of a specific disease, one of the most widely used technology is immunoassays. By using a specific antibody to recognize the biomolecule of interest, relatively high specificity can be achieved by immunoassays, such that complex biofluids (e.g. serum, urine, etc.) can be analyzed directly. In addition to the binding specificity, the other key features of immunoassays include relatively high sensitivity for the detection of antibody-antigen complexes, and a wide dynamic range for quantitation. Over the past decade, the development and applications of immunoassays have continued to grow exponentially. This book focuses on some of the latest technologies for the development of new immunoassays
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  • 46
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    ISBN: 9789533076942 , 9789535164906
    Language: English
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Immunology
    Abstract: The term "myositis" covers a variety of disorders often designated "idiopathic inflammatory myopathies". Although they are rather rare compared to other rheumatic diseases, they often cause severe disability and not infrequently increased mortality. The additional involvement of important internal organs such as the heart and lungs, is not uncommon. Thus, there is a great need for a better understanding of the etiopathogenesis of myositis, which may lead to improved treatment and care for these patients. Major advances regarding research and medical treatment have been made during recent years. Of particular importance is the discovery of the Myositis specific autoantibodies, linking immunological and pathological profiles to distinct clinical disease entities. A wide range of aspects of myopathies is covered in the book presented by highly qualified authors, all internationally known for their expertice on inflammatory muscle diseases. The book covers diagnostic, pathological, immunological and therapeutic aspects of myositis
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  • 47
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    ISBN: 9789533077864 , 9789535165569
    Language: English
    Pages: 1 Online-Ressource (380 p.)
    Keywords: Immunology
    Abstract: This book represents the culmination of the efforts of a group of outstanding experts in vasculitis from all over the world, who have endeavored to draw themselves into this volume by keeping both the text and the accompanying figures and tables lucid and memorable. The book provides practical information about the screening approach to vasculitis by laboratory analysis, histopathology and advanced image techniques, current standard treatment along with new and more specific interventions including biologic agents, reparative surgery and experimental therapies, as well as miscellaneous issues such as the extra temporal manifestations of "temporal arteritis" or the diffuse alveolar hemorrhage syndrome. The editor and each of the authors invite you to share this journey by one of the most exciting fields of the medicine, the world of Vasculitis
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  • 48
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    ISBN: 9789533074443 , 9789535166108
    Language: English
    Pages: 1 Online-Ressource (254 p.)
    Keywords: Immunology
    Abstract: "Inflammatory Diseases - A Modern Perspective" represents an extended and thoroughly revised collection of papers on inflammation. This book explores a wide range of topics relevant to inflammation and inflammatory diseases while its main objective is to help in understanding the molecular mechanism and a concrete review of inflammation. One of the interesting things about this book is its diversity in topics which include pharmacology, medicine, rational drug design, microbiology and biochemistry. Each topic focuses on inflammation and its related disease thus giving a unique platform which integrates all the useful information regarding inflammation
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  • 49
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    ISBN: 9789533076515 , 9789535165279
    Language: English
    Pages: 1 Online-Ressource (450 p.)
    Keywords: Immunology
    Abstract: This book represents the culmination of the efforts of a group of outstanding experts in vasculitis from all over the world, who have endeavored to devote their work to this book by keeping both the text and the accompanying figures and tables lucid and memorable. Here, you will find an amalgam between evidence-based medicine to one based on eminence, through an exciting combination of original contributions, structured reviews, overviews, state-of the-art articles, and even the proposal of novel pathogenetic models of disease. The book contains contributions on the etiology and pathology of vasculitis, the potential role of endothelial cells and cytokines in vascular damage and repair as well as summaries of the latest information on several primary and secondary vasculitis syndromes. It also covers selected topics such as organ-specific vasculitic involvement and quality of life issues in vasculitis. The editor and each of the authors invite you to share this journey through one of the most exciting fields of the medicine, the world of Vasculitis
    Note: English
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  • 50
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    ISBN: 9789533076539 , 9789535165637
    Language: English
    Pages: 1 Online-Ressource (630 p.)
    Keywords: Immunology
    Abstract: Autoimmune disorders are caused due to break down of the immune system, which consequently fails in its ability to differentiate "self" from "non-self" in the context of immunology. The diseases are intriguing, both clinically and immunologically, for their diversified clinical phenotypes and complex underlying immunological mechanisms. This book offers cutting-edge information on some of the specific autoimmune disease phenotypes, respective diagnostic and prognostic measures, classical and new therapeutic options currently available, pathogenesis and underlying mechanisms potentially involved, and beyond. In the form of Open Access, such information is made freely available to clinicians, basic scientists and many others who will be interested regarding current advances in the areas. Its potential readers will find many of the chapters containing in-depth analysis, interesting discussions and various thought-provoking novel ideas
    Note: English
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  • 51
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    ISBN: 9789533076430 , 9789535165378
    Language: English
    Pages: 1 Online-Ressource (504 p.)
    Keywords: Immunology
    Abstract: The present edition entitled "Autoimmune disorders - Pathogenetic aspects" aims to present the current available evidence of etiopathogenetic insights of both systemic and organ specific autoimmune disorders, the crossover interactions among autoimmunity, cardiovascular morbidity and malignancy as well as novel findings in the exciting fields of osteoimmunology and immunology of pregnancy
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  • 52
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    ISBN: 9789533078489 , 9789535167181
    Language: English
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Immunology
    Abstract: Rheumatology is a subspecialty of medicine that focuses on the biology, cause, diagnosis and the treatment of a variety of musculoskeletal and other systemic diseases. The field of rheumatology is expanding rapidly and several very exciting developments have occurred during the recent years. Firstly, there has been a new dramatic understanding of the nature of inflammation and the possibility of specifically regulating the aberrant immune inflammatory response. Secondly, an understanding of pathogenesis has lead to the development of new, more targeted therapies. Challenges in Rheumatology has assembled an impressive group of international experts who have studied specific aspects of certain rheumatic diseases and have extensive experience either in pathophysiology, or with the in-depth diagnosis and/or management of rheumatic patients. They communicate their knowledge and experience to the reader in chapters that are conveniently organized as pathophysiology, clinical manifestations and diagnosis of selected rheumatic diseases, medical and perioperative orthopedic management, and the economic impact of rheumatic diseases. We hope that this book will help trainees become better physicians and scientists, and that it will help practicing rheumatologists to provide better care, and ultimately, improve the quality of life of our patients
    Note: English
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