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  • MPI Ethno. Forsch.  (477)
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  • Medicine  (477)
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  • MPI Ethno. Forsch.  (477)
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  • 1
    Online Resource
    Online Resource
    Autobiographisches Wiedererzählen : Eine interdisziplinäre Studie im qualitativen Längsschnitt (2024)
    Bielefeld : transcript Verlag
    Details
    ISBN: 9783839471906 , 9783837671902
    Language: Undetermined
    Pages: 1 Online-Ressource (364 p.)
    Series Statement: Medical Humanities
    Keywords: Social, group or collective psychology ; Psychoanalytical theory (Freudian psychology) ; Medicine: general issues ; Biographie ; Erzählung ; Lebensgeschichte ; Wiedererzählung ; Interview ; Narratives Interview ; Identität ; Lebensgestaltung ; Medizin ; Therapie ; Krankheit ; Selbsterzählung ; Kultur ; Sprache ; Sozialpsychologie ; Psychoanalyse ; Kulturwissenschaft ; Biography ; Narrative ; Retelling ; Narrative Interview ; Identity ; Life Design ; Medicine ; Therapy ; Illness ; Culture ; Language ; Social Psychology ; Psychoanalysis ; Cultural Studies
    Abstract: Wie erzählen Menschen ihre Lebensgeschichten? Und wie verändern sich diese Erzählungen im Laufe der Zeit? Shevek K. Selbert widmet sich an der Schnittstelle von Biographieforschung, Psychologie und Erzählforschung vollumfänglich wiederholten biographisch-narrativen Interviews, die im Abstand von zehn Jahren geführt wurden. Als Pionierarbeit qualitativer Längsschnittforschung entwickelt er Methoden, um die Erzählversionen miteinander zu vergleichen - und bietet einen einzigartigen Einblick in die Dynamik sowie die (auch therapeutische) Bedeutung von Selbsterzählungen für die Identitätsbildung und die Lebensgestaltung
    Note: German
    URL: kostenfrei
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  • 2
    Online Resource
    Online Resource
    Artificial Intelligence and Machine Learning in Health Care and Medical Sciences : Best Practices and Pitfalls (2024)
    Cham : Springer Nature
    Details
    ISBN: 9783031393556 , 9783031393549
    Language: Undetermined
    Pages: 1 Online-Ressource (810 p.)
    Series Statement: Health Informatics
    Keywords: Medical equipment and techniques ; Information technology: general topics ; Nursing and ancillary services ; Computer science ; Biology, life sciences ; Public health and preventive medicine ; Predictive analytics ; Artificial intelligence ; Medicine ; Machine learning ; Causal discovery ; Causal inference ; Genomics ; Medical knowledge discovery ; Clinical risk models ; Clinical risk stratification
    Abstract: This open access book provides a detailed review of the latest methods and applications of artificial intelligence (AI) and machine learning (ML) in medicine. With chapters focusing on enabling the reader to develop a thorough understanding of the key concepts in these subject areas along with a range of methods and resulting models that can be utilized to solve healthcare problems, the use of causal and predictive models are comprehensively discussed. Care is taken to systematically describe the concepts to facilitate the reader in developing a thorough conceptual understanding of how different methods and resulting models function and how these relate to their applicability to various issues in health care and medical sciences. Guidance is also given on how to avoid pitfalls that can be encountered on a day-to-day basis and stratify potential clinical risks. Artificial Intelligence and Machine Learning in Health Care and Medical Sciences: Best Practices and Pitfallsis a comprehensive guide to how AI and ML techniques can best be applied in health care. The emphasis placed on how to avoid a variety of pitfalls that can be encountered makes it an indispensable guide for all medical informatics professionals and physicians who utilize these methodologies on a day-to-day basis. Furthermore, this work will be of significant interest to health data scientists, administrators and to students in the health sciences seeking an up-to-date resource on the topic
    Note: English
    URL: kostenfrei
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  • 3
    Online Resource
    Online Resource
    Soziale Arbeit in der Rehabilitation : Praxis und Wirkmechanismen Sozialer Arbeit in der medizinischen Rehabilitation (2024)
    Bielefeld : transcript Verlag
    Details
    ISBN: 9783839466049 , 9783837666045
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Series Statement: Gesundheit, Kommunikation und Gesellschaft
    Keywords: Social work ; Medicine: general issues ; Soziale Arbeit ; Medizinische Rehabilitation ; Wirkung ; Gesundheit ; Pflege ; Reha ; Zusammenarbeit ; Teilhabe ; Körper ; Medizin ; Sozialarbeit ; Public Health ; Social Work ; Health-related Rehabilitation ; Effect ; Health ; Care ; Cooperation ; Participation ; Body ; Medicine
    Abstract: Soziale Arbeit ist ein wichtiger Teil der medizinischen Rehabilitation. Die Ausgestaltung ihrer Leistungen und ihre potentielle Wirkung blieben bislang allerdings unklar. An dieser Stelle setzen die Autor*innen an und präsentieren die Ergebnisse des Forschungsprojekts SWIMMER: Im Rahmen eines qualitativen Forschungsprojekts wurde die sozialarbeiterische Praxis von Sozialdiensten medizinischer Reha-Einrichtungen untersucht und ein Wirkmodell der Sozialen Arbeit in diesem Bereich entwickelt. Die vergleichende Darstellung der Resultate richtet sich sowohl an Sozialarbeiter*innen als auch an Verantwortliche in den Reha-Einrichtungen, die ihre eigene Praxis reflektieren und einen tieferen Einblick in gängige Arbeitsstrukturen der Sozialdienste erhalten wollen
    Note: German
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  • 4
    Online Resource
    Online Resource
    Honorary Doctorate Dr. Souha Kanj (2023)
    Nijmegen : Radboud University Press
    Details
    Language: Undetermined
    Pages: 1 Online-Ressource (38 p.)
    Keywords: History ; Medicine
    Abstract: On 15 October 2020, in the middle of the COVID-19 pandemic, Dr. Souha Kanj received a Radboud honorary doctorate in recognition of her achievements in the field of infection control and prevention, efforts in antimicrobial stewardship, and research on various infectious diseases, particularly antimicrobial resistant (AMR) bacteria. This edition includes the laudatio and the speech of our honorary doctor. Kanj published the first overview of antibiotic resistance in Arab countries and discovered differences between neighboring countries in the epidemiology of antimicrobial resistance. She also developed infection prevention monitoring and education programs for healthcare workers, and private organizations in the Arab world. Thanks to her efforts, Lebanon has signed the WHO pledge for hand hygiene. Kanj is not only commended for her expertise, didactic skills, and contribution to medicine, but also for her resilience and strong belief in making a positive impact, despite the difficult journey she has been through, having studied during the Lebanese civil war and being faced with numerous challenges that hit Lebanon and the region after that
    Note: English
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  • 5
    Online Resource
    Online Resource
    The Pathophysiology of Preeclampsia and Eclampsia (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564111 , 9783036564104
    Language: Undetermined
    Pages: 1 Online-Ressource (334 p.)
    Keywords: Medicine
    Abstract: Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells
    Note: English
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  • 6
    Online Resource
    Online Resource
    Potentially Toxic Elements Pollution in Urban and Suburban Environments (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562377 , 9783036562384
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The importance of studying pollution via potentially toxic elements (PTEs) is becoming a key challenge considering the increasing concern about the presence of PTEs in the environment and their potential impacts on ecosystem functioning and public health due to their persistence and biotoxicity. Regional geochemical research, together with geostatistical computations which are used to identify source patterns of different pollutants related to the underlying geological features and/or anthropogenic activities, is the best approach for characterizing this pollution issue. The collection of research in this Special Issue, “Potentially Toxic Element Pollution in Urban and Suburban Environments”, represents the need of the scientific community to characterize the behavior, transport, fate, and ecotoxicological state of PTEs in environmental matrices in both urban and suburban settings. All the case studies collected are of relevant significance due to their quality, both in the methodologies and the achieved results, and interest to different environmental studies, from China to South Africa to Europe. My role as Guest Editor of this Special Issue was exciting and stimulating. I would like to express my appreciation to all the authors for submitting their original contributions and to the reviewers for their essential role in the process. I would like to thank the editors of Toxics and, in particular, Selena Li for her precious and tireless support
    Note: English
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  • 7
    Online Resource
    Online Resource
    Current Challenges and Advances in Cataract Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562773 , 9783036562780
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed
    Note: English
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  • 8
    Online Resource
    Online Resource
    Pediatric Fractures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561424 , 9783036561417
    Language: Undetermined
    Pages: 1 Online-Ressource (244 p.)
    Keywords: Medicine
    Abstract: This reprint contains original research and review chapters concerning the latest advancements in various topics related to pediatric fractures. Topics include fractures of the face, clavicle, shoulder, elbow, forearm, wrist, pelvis, femur, and tibia; special considerations focus on osteogenesis imperfecta patients; and consideration is also given to general pediatric fracture topics, such as the influence of the COVID-19 pandemic, mortality after pediatric trauma, the effects of NSAID and electronic cigarette use, and chapters on epidemiology and physical activity
    Note: English
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  • 9
    Online Resource
    Online Resource
    Dietary Curcumin and Health Effects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036560878 , 9783036560885
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine
    Abstract: The Special Issue provides twelve contributions, of which three original articles, seven narrative reviews, one systematic review, and one meta-analysis that, altogether, offer a multifaceted and multidisciplinary overview that allows to draw a picture as intriguing and fascinating as possible on the benefits of curcumin and also to suggest potential fields of activities still to be explored. Among the biological activities exerted by curcumin, the anti-oxidative and anti-inflammatory properties reported in many studies make it a potential effective tool in preventing and counteracting chronic-degenerative diseases, very often associated with obesity and aging, such as cardiovascular diseases, T2D, metabolic dysfunctions, neurodegenerative diseases, and cancer, all of them characterized by the presence of oxidative and inflammatory processes. The main concerns that arise from the evaluation of the preventive/therapeutic effects of curcumin are, first of all, the still small number of randomized placebo-control studies available; in addition, small sample sizes have generally been considered, and different protocols and different formulations as well as different routes of administration of curcumin have been used. Thus, it is quite difficult to compare the results and to provide a standard protocol for the use of this promising natural compound. For these reasons, and taking in account the growing use of curcumin by the general population, further investigations to confirm and expand current findings are mandatory and research on curcumin and its effects on human health have to be fostered and promoted
    Note: English
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  • 10
    Online Resource
    Online Resource
    Stabilization and Resuscitation of Newborns (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564470 , 9783036564463
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine
    Abstract: The majority of newborns do not need medical interventions to manage the neonatal transition after birth. However, every year millions of newborns worldwide require respiratory support immediately after birth, and another considerable number of newborns additionally require extensive resuscitation including chest compressions and drug administration. Despite a significant increase in knowledge and development of enhanced therapy strategies over the past few years, morbidity and mortality caused by failures in neonatal transition remain an important health issue. The purpose of this reprint is to support or introduce novel concepts and add information in the area of the “Stabilization and Resuscitation of Newborns”, aiming to improve neonatal care and, as the major objective, to enhance neuro-developmental outcomes
    Note: English
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  • 11
    Online Resource
    Online Resource
    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis : Diagnosis and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559698 , 9783036559704
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches
    Note: English
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  • 12
    Online Resource
    Online Resource
    State of the Art in Idiopathic Pulmonary Fibrosis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563855 , 9783036563848
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: This reprint is a compilation of ten publications, including original-research and review articles, and the accompanying editorial within the scope of a Special Issue entitled: "State of the Art in Idiopathic Pulmonary Fibrosis" published in Cells
    Note: English
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  • 13
    Online Resource
    Online Resource
    Marine Toxins from Harmful Algae and Seafood Safety (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561943 , 9783036561936
    Language: Undetermined
    Pages: 1 Online-Ressource (264 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The rapid expansion of aquaculture around the world is increasingly being impacted by toxins produced by harmful marine microalgae, which threaten the safety of seafood. In addition, ocean climate change is leading to changing patterns in the distribution of toxic dinoflagellates and diatoms which produce these toxins. New approaches are being developed to monitor for harmful species and the toxins they produce. This Special Issue covers pioneering research on harmful marine microalgae and their toxins, including the identification of species and toxins; the development of new chemical and biological techniques to identify and monitor species and toxins; the uptake of marine biotoxins in seafood and marine ecosystems; and the distribution and abundance of toxins, particularly in relation to climate change
    Note: English
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  • 14
    Online Resource
    Online Resource
    Biomedical Imaging Technologies for Cardiovascular Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570068 , 9783036570075
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint aims to provide an update on the biomedical imaging technologies that can be used for cardiovascular diseases, including Doppler echocardiography, magnetic resonance imaging and positron emission tomography. Cardiovascular disease imaging assessment includes anatomy, hemodynamics, and tissue biomarkers, which aid the stratification of patient risk and therapy. In addition, this Special Issue includes articles that discuss the recent integration of artificial intelligence and machine learning, in order to support novel approaches to personalized image-based diagnosis
    Note: English
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  • 15
    Online Resource
    Online Resource
    Focus on Antibiotics – New Challenges and Steps Forward in Discovery and Development (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572017 , 9783036572000
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The Special Issue "Focus on Antibiotics - New Challenges and Steps Forward in Discovery and Development" addresses the latest efforts towards discovering new antibiotics. The articles in this Special Issue cover various topics concerning antibacterial drugs. They provide valuable insights into the challenges and opportunities facing the field of antibiotic research and offer innovative solutions to tackle the growing problem of antibiotic resistance. The content of this Special Issue addresses antibacterial quinolones of the latest generation, new tetracyclines (such as glycylcyclines, aminomethylcyclines, and fluorocyclines), metal complexes (Ru (II/III) frameworks and Co(III) complexes with diamine chelate ligands), various nanoparticles (gold, silver and titanium dioxide nanoparticles), bioactive compounds produced by Mixobacterials species, anti-mycobacterial compounds acting as phosphopantetheinyl transferase inhibitors. The research in this Special Issue will contribute to pharmaceutics and ultimately contribute to developing new and effective antibiotics. We are grateful to the authors for their contributions and hope this Special Issue will stimulate further research and discussion on antibiotics. We also thank the reviewers for their time and expertise, and the editorial team for supporting this Special Issue. Finally, we hope this Special Issue will serve as a valuable resource for researchers, clinicians, and policymakers working towards a future where antibiotics remain vital in our fight against infectious diseases
    Note: English
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  • 16
    Online Resource
    Online Resource
    Nutritional Support for Chronic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570624 , 9783036570631
    Language: Undetermined
    Pages: 1 Online-Ressource (222 p.)
    Keywords: Medicine
    Abstract: Diet contributes to the development of many chronic conditions including obesity, cardiovascular disease, hypertension, stroke, type 2 diabetes, metabolic syndrome, some cancers, non-alcoholic fatty liver disease, and potentially some neurological diseases. This reprint addresses associations between diet (and specific nutrients including vitamin D) and various chronic diseases including obesity, cardiovascular disease, hypertension, stroke, diabetes, metabolic syndrome, non-alcoholic fatty liver disease, neurological conditions, and age-related macular degeneration. More specifically, the impacts of plant-based diets, dairy products, and ketogenic diets are explored in relation to chronic disease risk as well as some benefits of the consumption of oral nutritional supplements in the prevention of malnutrition and sarcopenia and in the treatment of wounds in individuals with diabetes. Additional topics that are covered include some roles of the fatty acid arachidonic acid in the body and the impact of cellular mitochondrial dysfunction on the progression of age-related macular degeneration. The effectiveness of a variety of nutraceuticals is covered as a means for the prevention or treatment of age-related macular degeneration. Lastly, the use of olive oil in reducing gut permeability in those with pre-diabetes is addressed, as well as the complex relationships of diet/food and of disease (metabolic syndrome) with the gut microbiota
    Note: English
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  • 17
    Online Resource
    Online Resource
    Novel Applications and Technologies for the Industrial Exploitation of Algal Derived Marine Bioactives as Nutraceuticals or Pharmaceuticals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570082 , 9783036570099
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The active molecules or bioactives (i.e., polysaccharides, fatty acids, proteins, polyphenols, diterpenes, steroids and alkaloids) from algae (seaweed and microalgae) have been widely studied in recent years for multiple pharmaceutical and nutraceutical applications. Innovative and emerging technologies, including but not limited to ultrasounds, microwaves, electric fields, high-pressure supercritical fluids, ionic fluids and plasma, are currently being explored throughout multiple stages of the pre-treatment, extraction, isolation/purification and preservation of biomolecules from algae. This Special Issue will target research papers, reviews, short communications and perspectives on the use of novel technologies for the pre-treatment, extraction, isolation‒purification, characterization and preservation of marine compounds from algae. It will particularly focus on novel research related to algal bioactives with clear and demonstrated industrial applications and focuses
    Note: English
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  • 18
    Online Resource
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    Novel Anticancer Strategies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570310 , 9783036570303
    Language: Undetermined
    Pages: 1 Online-Ressource (396 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies reviews important findings and updates within the cancer therapy field, of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key features: Nanoparticle-based drug delivery in cancer therapy; Extracellular vesicles for anticancer drug delivery; Peptide-based drug conjugates; Cancer stem cells as a valuable target to eradicate tumor relapse; Spheroids in preclinical model for cancer research; and cancer immunotherapy
    Note: English
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  • 19
    Online Resource
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    Novel Therapeutic Considerations in Bone and Soft Tissue Sarcoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570150 , 9783036570143
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medicine ; Oncology
    Abstract: Sarcomas are a group of rare cancers that arise in connective tissues of the body. Surgical resection is pivotal for the management of locoregional disease. In locally advanced or metastatic disease settings, systemic therapy has an important role in the multidisciplinary management of sarcoma. Cytotoxic therapy has been the primary treatment for many years. However, recent advances in molecular pathogenesis, the investigation of the tumour microenvironment, changes in clinical trial design, and increased international collaboration have led to the development of histology-driven therapy. Furthermore, genomic profiling has highlighted that, while some sarcomas have complex karyotypes, others are driven by translocation, amplification, and mutation, representing targets for the development of novel therapies. Checkpoint inhibitors have been used as single agents or in combination in clinical sarcoma trials. This progress will move the therapeutic modality in sarcoma patients from the “one-size-fits-all” approach towards a more personalized therapeutic algorithm and better outcomes soon. In this Special Issue, we present original research and review articles highlighting novel therapeutic approaches in the treatment of sarcoma patients
    Note: English
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  • 20
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    State-of-the-Art in Orthodontics and Gnathology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569369 , 9783036569376
    Language: Undetermined
    Pages: 1 Online-Ressource (78 p.)
    Keywords: Medicine
    Abstract: The objective of this reprint is to present the main evidence-based data on new developments and knowledge in diagnostic and treatment technologies in the orofacial field used in both children and adults. The published content has been met with great success in interdisciplinary fields, stimulating international authors to submit their original articles, reviews, or case reports based on various aspects of orthodontics as well as on the diagnosis and management of temporomandibular disorders and orofacial pain. Among the current highly debated topics, this reprint focuses on multiple disciplines as follows: gingival recessions and periodontal status after orthodontic treatment; a rare case of impacted central incisors; predictors of analgesic consumption in orthodontic patients; a systematic review about different dentoskeletal class III treatment approaches; evaluation of upper airway volumes; and cephalometric values in JIA patients
    Note: English
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  • 21
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    Urological Cancer 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569680 , 9783036569697
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine ; Oncology
    Abstract: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit
    Note: English
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  • 22
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    Marine Anti-inflammatory and Antioxidant Agents 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567846 , 9783036567853
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medicine
    Abstract: The Special Issue “Marine Anti-Inflammatory and Antioxidants Agents 2.0” collects in vitro and/or in vivo experimental investigations highlighting the role of marine-derived bioactive compounds as modulators of inflammation and/or oxidative stress, papers describing the mechanisms of action and molecular interactions of compounds isolated from marine organisms, and comprehensive review articles summarizing knowledge on marine anti-inflammatory and/or antioxidant agents in support of human health
    Note: English
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  • 23
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    Biomarkers of Stress in Companion Animals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571249 , 9783036571256
    Language: Undetermined
    Pages: 1 Online-Ressource (102 p.)
    Keywords: Medicine
    Abstract: The welfare of an individual could be severely affected by stressful events. Mainly for this reason, the scientific community is interested in finding specific and quantifiable characteristics which could indicate or predict specific signs of acute or chronic stress exposure. The aim of this reprint is to reflect this interest in the field of companion animal physiology. The authors engaged in publishing this reprint are experts in the multiple mechanisms involved in stress response, including the detection of behavioral and physical signs which can be measured through biological indicators of homeostasis displacement. The editors strongly believe this topic will be of interest not only to researchers in this field, but also to dog trainers, dog shelter workers and veterinary behaviorists
    Note: English
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  • 24
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    Chemical and Biological Threats, Hazard Potential and Countermeasures (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036550374 , 9783036550381
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: In this Special Issue of Toxics entitled, “Chemical and biological threats, hazard potential and countermeasures”. In this special issue we would like to pay attention to various aspects of toxicology specifically focused on the chemical and biological threats, which may accidentally or on purpose endanger human health. Besides the characterization of such threats and their biological consequences we will focus on the available and novel experimental countermeasures capable to protect from and/or threat such exposures
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    Bio-Active Products from Mangrove Ecosystems (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036575261 , 9783036575278
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas, between 5°N and 5°S latitudes, spanning over 118 countries. The special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for the metabolic pathway via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have taken the limelight as an attractive biodiversity hotspot, attracting significant attention from organic chemists and pharmacologists. Additionally, many unique and novel chemical structures with a wide range of structural classes have suggested various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles describing recent studies and pertinent reviews focusing on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of putting together a group of top researchers whose work we would like to feature in this collection, and we would like you to participate
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    Minimally Invasive Urological Procedures and Related Technological Developments—Series 2 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577661 , 9783036577678
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Medicine ; Surgery
    Abstract: We are in the modern era of innovations, technological developments and minimisation in the field of urology. While laparoscopy and robotic surgery have revolutionised pelvic and upper tract oncology, there is continuous evolution and increasing use of these in the field of benign conditions and paediatric urology. As lasers have changed endourology, new minimally invasive surgical techniques (MISTs) have given a new meaning to benign prostate hyperplasia (BPH) surgery. Oncological developments for prostate cancer now include treatments such as robotic prostatectomy, brachytherapy, radiotherapy, cryotherapy and HIFU. Robotic partial nephrectomy and cryotherapy have changed the face of renal cancer. While robotic cystectomy is also gaining popularity for muscle-invasive bladder cancer, new concepts of En-bloc resection of bladder cancer are emerging and being increasingly adopted. MISTs for BPH include laser (Holmium, thulium and green light), water-based treatments (Rezum, Aquablation) and other minimally invasive procedures such as prostate artery embolisation (PAE), TIND and Urolift. There is increasing emphasis on the role of suction in endourological procedures, while the quest for better intrarenal pressure and temperature monitoring continues. The use of Thulium fibre laser (TFL), Moses technology and small disposable ureteroscopes all help in pushing the boundaries of ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL) procedures. These new technological developments have led to improvements in patients’ quality of life (QoL), shorter hospital stays and reductions in complication rates
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    Auditory and Phonetic Processes in Speech Perception (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574134 , 9783036574127
    Language: Undetermined
    Pages: 1 Online-Ressource (298 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: In the past two decades, great advancements have been made in phonetic, auditory, and psycholinguistic research on speech perception. As the fields have advanced, there has been increasing interdisciplinary collaboration between them, which has, in turn, revealed their interdependence. The aim of this Special Issue is to bring together top scholars in these three related areas to present research in a single volume with papers ranging from the neurophysiology of hearing, to phonetic and linguistic factors, to factors related to hearing loss and assistive devices, second language learning and accentedness, and the processing of speech and the mental lexicon. We invite you all to read the high-quality papers in this Special Issue
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    Recent Advances in Dual Disorders (Addiction and Other Mental Disorders) (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577005 , 9783036577012
    Language: Undetermined
    Pages: 1 Online-Ressource (162 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Dual disorders, meaning the coexistence in the same individual of a substance use disorder and another mental disorder, have become an area of great interest in the fields of psychiatry and addiction and in health overall due to their high prevalence, clinical relevance and multicultural presence. This book includes a compilation of papers published between the end of 2021 and the beginning of 2023 focused on recent advances in dual disorders. The contributions present a broad look at various relevant aspects. Among them are the characterization of patients treated in different services, with special interest in the risk of overdoses, suicidal attempts and HIV, as well as the so-forgotten gender perspective and the impact of the COVID-19 pandemic on the attention of addiction centers. One of the first studies to consider the comorbidity of gambling disorders with substance use is also presented. The possible usefulness of explanatory models of machine learning for diagnosis and for performing chronobiological measurements that allow a more individualized treatment stand out among the novel contributions to the field of dual disorders. The aim of each of the contributions of this reprint is to be transferred for the benefit of clinical practice
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    The Digital Health in the Pandemic Era (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577333 , 9783036577326
    Language: Undetermined
    Pages: 1 Online-Ressource (298 p.)
    Keywords: Medicine ; Mental health services
    Abstract: Digital health, virtual assistance, and telemedicine are terms often used interchangeably to refer to remote medical assistance, monitoring and care. Several studies and insights have developed these issues, analyzing the advantages and disadvantages and successes and failures and offering reflections on the implications and issues of these technologies in the health domain. The results of these investigations are affecting the redesign of hospital and outpatient management based on digital innovation using eHealth and mHealth. During the COVID-19 pandemic, this approach made it possible to offer assistance and continue care at home, protecting patients, preserving health workers, limiting the spread of the virus, and reducing the need for hospitalization. This reprint contains contributions dealing with the development of DH during the COVID-19 pandemic. The contributions are from various experts in different fields regarding the application of digital health, which, in some cases is also integrated with artificial intelligence, including digital contact tracing, mHealth, virtual reality, mental health, physiology, and rehabilitation
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    Food Addiction, Eating Addiction and Other Forms of Addictive-Like Eating Behavior (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574660 , 9783036574677
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine
    Abstract: There is growing evidence that among persons with disordered eating behavior, the identification of an “addictive-like eating” phenotype for some persons could be relevant and improve our ability to design better tailored interventions. This “addictive-like eating behavior” phenotype encompasses different terms or concepts, including “food addiction”, “eating addiction”, “compulsive eating behavior”, and “food craving”, but also applies to some persons with binge eating disorder, bulimia nervosa, anorexia nervosa, or binge eating symptoms. Although these terms may theoretically refer to different underlying causes or conceptualizations of addictive-like eating, all agree on the complex and multifaceted public health problem it represents and on the similarities it shares with other addictive disorders in terms of etiology, epidemiology, and treatment. Addictive-like eating behavior can deleteriously impact the patient’s outcome and may lead to poorer weight loss evolution, increased prevalence of co-occurring medical and/or psychiatric disorders, and/or lower quality of life. One of the key challenges for the present and future research is to better identify this subpopulation of patients exhibiting this addictive-like eating phenotype, and to identify the psychological/psychiatric factors and biological mechanisms underlying this increased vulnerability to addictive-like eating. Such preliminary knowledge is crucial for enabling the development of interventions targeting these vulnerability risk factors and, ultimately, improving patient outcomes
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    Update on Robotic Gastrointestinal Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576794 , 9783036576787
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Since the introduction of robotic surgery in the early 2000s, several studies have demonstrated its safety and feasibility in various complicated procedures, including esophageal, gastric, and colorectal surgery (for both benign and malignant pathologies), hepatobiliopancreatic surgery, and gynecological and urological procedures.Robot-assisted surgery provides the advantages of a magnified tridimensional view and movement stability without a tremor, which facilitate a precise dissection. The EndoWrist instrument also facilitates dissection at difficult angles, thus enabling surgery in complex conditions.Even if some of the advantages of robotic surgery have been defined, we are still far from clearly recognizing precise indications for a robotic approach in gastrointestinal surgery.With this Special Issue, we aim to investigate the conditions that support the robotic approach in gastrointestinal surgery toward the definition of gold-standard robotic procedures, as established in urological surgery for prostatectomy
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    Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574615 , 9783036574608
    Language: Undetermined
    Pages: 1 Online-Ressource (250 p.)
    Keywords: Medicine
    Abstract: The reprint, “Rare Monogenic Diseases: Molecular Pathophysiology and Novel Therapies”, provides a collection of original research articles and systematic reviews focused on diverse conditions stemming from a pathogenic single gene mutation. The articles are focused on the molecular mechanisms that are affected within a rare monogenic disorder, such as those involving gene expression, molecular pathways and cell death. Moreover, specific experimental therapies including drug discovery, drug repositioning, gene therapy and protein-based therapeutics are discussed
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    Carbazole Derivatives: Latest Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572888 , 9783036572895
    Language: Undetermined
    Pages: 1 Online-Ressource (98 p.)
    Keywords: Medicine
    Abstract: Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, “Carbazole derivatives: latest progress and prospects”, recent studies on carbazole derivatives that are utilized, such as β1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported
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    Pathogenesis of Pregnancy-Related Complication (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573274 , 9783036573267
    Language: Undetermined
    Pages: 1 Online-Ressource (352 p.)
    Keywords: Medicine
    Abstract: In this Special Issue, "Pathogenesis of Pregnancy-Related Complications", 4 reviews, 13 original papers, 1 communication, and 1 case report are compiled. These papers were published by scientific teams from 24 countries, including China, Tunisia, Canada, France, Serbia, Portugal, Spain, Chile, Singapore, Australia, the USA, Mexico, the Czech Republic, Germany, Sweden, Finland, the United Kingdom, Norway, Poland, Greece, Japan, Italy, Switzerland, and Israel, which is a really great achievement
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    Composite and Polymeric Materials for Dentistry : Enhancing Antimicrobial and Mechanical Properties (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571836 , 9783036571829
    Language: Undetermined
    Pages: 1 Online-Ressource (378 p.)
    Keywords: Medicine
    Abstract: Billions of people suffer from dental problems. Paradoxically, the deteriorating state of teeth is accompanied by the ever-increasing desire to preserve the best facial appearance, which is significantly influenced by teeth aesthetics. This favors the development of dental materials and manufacturing technologies for dental prosthetics, needed to achieve expected effects of clinical treatment.This reprint focus on enhancing antimicrobial and mechanical properties of polymeric materials and composites for dentistry. In recent years, special attention has been focused on the possibility of giving materials new or improved properties by the introduction of nano or submicron size additives, fibers or whiskers. Using agents such as natural oils to enhance antimicrobial properties remains an exciting idea. Another area of research is the application of antibacterial monomers, which can be copolymerized in resins to kill oral pathogenic microflora. The use of new monomers or new compilations of various monomers to improve mechanical properties has also aroused interest. In addition, we are currently looking for new data regarding colonization of dental materials by pathogenic microbes and their influence on the other properties. Further, there are many new commercially available materials which should be investigated to verify their properties, which is important from the point of view of clinical practice. Original new research and reviews related to any of the topics mentioned above indicate the current directions of development of dental materials. We hope that the presented work will be of interest to readers
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    Environmental Exposure to Toxic Chemicals and Human Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572697 , 9783036572680
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors
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    The Challenges of COVID-19 with Obesity-Related Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573519 , 9783036573502
    Language: Undetermined
    Pages: 1 Online-Ressource (224 p.)
    Keywords: Medicine
    Abstract: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research
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    Mental Health Challenges during the COVID-19 Pandemic (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571959 , 9783036571942
    Language: Undetermined
    Pages: 1 Online-Ressource (250 p.)
    Keywords: Medicine ; Mental health services
    Abstract: The aim of the reprint was to provide readers with updated research findings on the psychological and psychiatric consequences of the pandemic. The wide scope of the reprint reflects the complexity of the impact of the COVID-19 pandemic on mental health. The focus of the studies ranges from the psychological consequences of social distancing and the closure of schools to the neurological consequences of the viral infection, and from the stressful impact of an increased workload on frontline health workers to the unmet needs of special populations such as pregnant women, veterans and patients with neurodevelopmental disorders. Thanks to its richness in content and worldwide perspectives (contributors were from Canada, Croatia, Greece, India, Israel, Italy, Pakistan, the Philippines, Poland, Spain, and the USA), the reprint is a valuable source of information to researchers and clinicians interested in the mental health implications of the COVID-19 pandemic
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    Genetic and Epigenetic Regulations of Tumor Progression and Metastasis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036571850 , 9783036571843
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine ; Oncology
    Abstract: Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease
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    Immunotherapy in Hepatocellular Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566917 , 9783036566900
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Oncology
    Abstract: Based on this evidence, a deep understanding of the immunological status and biological targets modulating immunological microenvironments should be quite informative for the development of future immunotherapy in HCC. From this point of view, this Special Issue will highlight the current state of the art in the immunotherapy of HCC from both the basic and clinical perspectives, and outline future perspectives for improving therapies
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    Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036583839 , 9783036583822
    Language: Undetermined
    Pages: 1 Online-Ressource (400 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint contains five original research papers and eight review articles for the Special Issue "Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components" which is guest edited by Prof. Dr. Anupam Bishayee. There is one item that indicated the correction of one review
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    Artificial Intelligence (AI) and Machine Learning (ML) in Medical Imaging Informatics towards Diagnostic Decision Making (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036581286 , 9783036581293
    Language: Undetermined
    Pages: 1 Online-Ressource (238 p.)
    Keywords: Medicine
    Abstract: In recent years, AI/ML tools have become more prevalent in the fields of medical imaging and imaging informatics, where systems are already outperforming physicians in a range of domains, such as in the classification of retinal fundus images in ophthalmology, chest X-rays in radiology, and skin cancer detection in dermatology, among many others. It has recently emerged as one of the fastest growing research areas given the evolution of techniques in radiology, molecular imaging, anatomical imaging, and functional imaging for detection, segmentation, diagnosis, annotation, summarization, and prediction. The ongoing innovations in this exciting and promising field play a powerful role in influencing the lives of millions through health, safety, education, and other opportunities intended to be shared across all segments of society. To achieve further progress, this Special Issue (SI) invited both research and review-type manuscripts to showcase ongoing research progress and development based on applications of AI/ML (especially DL techniques) in medical imaging to influence human health and healthcare systems in the diagnostic decision-making process. The SI published fourteen articles after a rigorous peer-review process across the spectrum of medical imaging modalities and the diversity of specialties depending on imaging techniques from radiology, dermatology, pathology, colonoscopy, endoscopy, etc
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    Application of Nanomedicine in Immunotherapy: Recent Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036582405 , 9783036582412
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: Nanomedicine is a special medical field focused on the application of nanotechnology to provide innovations for healthcare in different areas, including the treatment of a wide variety of diseases, including cancer, infections, and auto-immune disorders. The field emerged during the 1980s, aligning with the approval of the first regulatory-agency-approved nanomedical oncological drugs. Additionally, nanotechnology has played a pivotal role in the development of mRNA vaccines utilized during the COVID-19 pandemic, further establishing its enduring significance in the domains of science and biomedical innovation. The reasons for the use of nanotechnology in biomedicine can vary but are mostly the protection and/or delivery of bioactive molecules to target tissues. The general idea is to create nanoscopic platforms that can interact differently with biological systems, either through pharmacokinetic modifications or through the preferential activation of some biological pathway. The intricate biomolecular interactions that underlie the functioning of the biological system take place within the nanoscale. So, nanoparticles can be designed to be similar in size to key biological structures like large biomolecules or small organelles, enabling them to interact with biological systems in unique ways, which can improve the effects of drugs used in the treatment of certain diseases. In other words, highly distinct and improved biological effects can emerge from such interactions
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    Feature Papers in 〈em〉 NeuroSci 〈/em〉: From Consciousness to Clinical Neurology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036578460 , 9783036578477
    Language: Undetermined
    Pages: 1 Online-Ressource (256 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: This reprint focuses on relevant findings in the field of neuroscience, ranging from cognitive neuroscience, including studies on human consciousness, to clinical neurology, including studies on autism and epilepsy. Furthermore, the latest methods in the expanding field of neuroscience from cognitive to clinical subdisciplines will also be available to the readers
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    Biomechanics-Based Motion Analysis (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036580272 , 9783036580265
    Language: Undetermined
    Pages: 1 Online-Ressource (386 p.)
    Keywords: Medicine
    Abstract: Collectively, the studies presented in this reprint have used various validated biomechanical models or proposed novel methods of motion analysis to gain new insights into health-related problems and sports performance
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    Marine Bioactive Peptides—Structure, Function, and Application (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036582603 , 9783036582610
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In recent years, peptides generated from various marine organisms have attracted wide attention due to their diverse chemical structures and bioactivities, including antioxidant, immune-modulating, angiotensin-I-converting enzyme (ACE)-inhibitory, hypotensive, hypolipidemic, antiviral, cytotoxic, neurotoxic, anticoagulant, antifreeze, etc. Moreover, bioactive peptides can serve as additional functional components used in health foods, nutraceuticals, bio-preservatives, cosmetics, and pharmaceuticals. The Special Issue on “Marine Bioactive Peptides—Structure, Function, and Application” aimed to collect papers on up-to-date information regarding the preparation, structural identification, activity and functional evaluation, and application of marine bioactive peptides
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    New Insights into Antithrombotic Therapy for Cardio- and Cerebrovascular Disease: From Molecular Mechanisms to Clinical Application (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036581163 , 9783036581170
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Thrombosis is a pathophysiological phenomenon observed in acute and chronic coronary syndrome, stroke, and peripheral artery disease. Exposure of the Tissue Factor (TF) to flowing blood is followed to its binding to other coagulation factors leading to thrombin formation. Together with platelet activation, TF ultimately promotes thrombus formation. Recent advances in platelet pathophysiology have shown that these cells are able to regulate their gene/protein expression, engage in de novo protein synthesis, and release different mediators that may interfere with different cell functions. Several clinical trials have clearly shown the efficacy of anticoagulation and/or anti-platelet aggregation in different thrombotic disorders. Real-world practice clearly indicates that antithrombotic strategies need to be personalized according to patient characteristics. The combination of multiple antithrombotic drugs represents a challenging scenario and was the focus of multiple recent randomized controlled trials, with more still to come. As knowledge about platelets and the coagulation system has substantially evolved within the last few years, so should our approach to antithrombotic treatment; focused on current hurdles of antithrombotic treatments in patients with cardio- and cerebrovascular diseases, starting from the molecular mechanisms involved, proposing practical solutions to compelling clinical scenarios using a pathophysiology-oriented approach on the basis of current clinical evidence
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    Chronic Kidney Disease: Underlying Molecular Mechanisms (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036585413 , 9783036585406
    Language: Undetermined
    Pages: 1 Online-Ressource (216 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Chronic kidney disease (CKD) is a worldwide public health problem that must be addressed. The global increase in CKD prevalence is associated with an increase in conventional disease risk factors (e.g., diabetes and hypertension), which may be exacerbated by additional variables such as environmental and occupational exposure to toxic compounds. Authors contributed to this Special Issue by highlighting the finding of potential novel biomarkers of the disease and more effective therapy alternatives, as well as works that enhance the understanding of CKD pathogenesis and its related complications
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    Integrating Clinical and Translational Research Networks—Building Team Medicine - Series 2 (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036584720 , 9783036584737
    Language: Undetermined
    Pages: 1 Online-Ressource (230 p.)
    Keywords: Medicine ; Oncology
    Abstract: The previous Special Issue of the Journal of Clinical Medicine, ‘Integrating Clinical and Translational Research Networks—Building Team Medicine’, which highlighted our collective experience from the City of Hope and was published in 2020, was a huge success. Buoyed by the enthusiastic response from our peers and colleagues, we have embarked on bringing out Volume 2. The basic theme is the same—namely, integrating academic medical centers with the clinical network in various geographic locations to ensure that all patients, regardless of their physical proximity to major medical institutions, can benefit from recent clinical advances. As in the previous volume on the importance of including basic research scientists, our aim here is to highlight translational research approaches that leverage the combined knowledge, skills, experience, expertise, and vision of clinicians in academic medical centers, their affiliated community centers, and hospitals, together with those of basic research scientists. However, here we also strive to include bioinformaticians and data scientists. We look forward to sharing our team medicine experience with our colleagues around the world and trust that they will find the approach described in the articles included in this Special issue useful for guiding their approaches for treating cancer patients
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  • 50
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    Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579375 , 9783036579368
    Language: Undetermined
    Pages: 1 Online-Ressource (184 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint brings together a group of articles that were published as a Special Issue on prosthetic joint infection in the journal Antibiotics. They cover various aspects of risk factors and prevention, medical and surgical treatment, and outcomes of prosthetic joint infections
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    10th Anniversary of JCM : Recent Diagnostic and Therapeutic Advance in Gastroenterology and Hepatopancreatobiliary Medicine (2023)
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036583921 , 9783036583938
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine
    Abstract: The year 2021 marks the 10th anniversary of Journal of Clinical Medicine, and as one of the major sections of JCM, we are launching a 10th anniversary Special Issue in the section “Gastroenterology & Hepatopancreatobiliary Medicine”. We accepted papers for the Special Issue, titled "Recent diagnostic and therapeutic advance in Gastroenterology & Hepatopancreatobiliary Medicine". This medical field is a complex and wide-ranging field that deals with diseases in multiple organs such as the gastrointestinal tract and hepatobiliary pancreas. With recent advances in diagnostic imaging and interventional treatment, those in endoscopic diagnosis and treatment, those in functional test and those in genetic diagnosis and drug therapy, including the molecular-targeted therapy, many new medical findings have been accumulated. In this Special Issue, we looked for reports that make full use of advances in diagnostics and therapeutics in the field of Gastroenterology and Hepatopancreatobiliary Medicine
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    Breast Cancer Imaging and Therapy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579306 , 9783036579313
    Language: Undetermined
    Pages: 1 Online-Ressource (228 p.)
    Keywords: Medicine ; Oncology
    Abstract: In Canada, survival from breast cancer has steadily increased since 1989, and breast cancer mortality has decreased by 48%. While 82% of women with breast cancer are diagnosed at stage 1 or 2, there are still 18% who present at a late stage and 25% who develop metastatic disease. Improved survival has been achieved through early diagnosis of breast cancer with screening, allowing for more effective and targeted treatments. This reprint summarizes the latest evidence on the early detection of breast cancer and highlights areas where this may be improved
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    Coronary Syndrome: Clinical Treatment, Prevention and Management for Better Outcomes (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579122 , 9783036579139
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes
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  • 54
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    Young-Onset GI Cancer (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579641 , 9783036579658
    Language: Undetermined
    Pages: 1 Online-Ressource (134 p.)
    Keywords: Medicine ; Oncology
    Abstract: In the last decade, the incidence of cancer in young patients has increased in several cancer types according to the US Surveillance, Epidemiology and End Result (SEER) data and other worldwide registries. Recently, Sung and colleagues published an extensive pooled analysis from the US in Lancet Public Health, which revealed a dramatic increase in cancer incidence among younger adults (aged 25–49 years), mainly in “obesity-related” cancers, most of which occur in the gastrointestinal (GI) tract. Several studies over the past decade have indicated a significant increase in colorectal cancer incidence among young adults below the age of 50 years. Current evidence suggests that the majority of early-onset GI cancers are sporadic and harbor no familial etiology, indicating the potentially significant role of environmental and behavioral factors in their pathogenesis. Furthermore, the gut microbiome has been proposed to play a key role in CRC carcinogenesis. The scope of this Special Issue of Cancers is to highlight perspectives regarding biology, etiology, late-term toxicities and quality of life which are unique and relevant to young-onset GI cancer cases
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  • 55
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    Application of Botulinum Neurotoxin in Lower Urinary Tract Dysfunctions: Where Are We Now? (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579382 , 9783036579399
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Medicine
    Abstract: Evidence has shown that botulinum toxin A has advantages in lower urinary tract dysfunctions (LUTDs), especially in interstitial cystitis, urethral sphincter dysfunction, and inflammatory bladder disorders which currently cannot be adequately treated with oral pharmacological medications. This Special Issue has collected original or review articles that focus on the novel applications of botulinum toxin A in LUTDs. The research has been updated and contains novel therapeutic applications of botulinum toxin for bladder or urethral dysfunctions. This Special Issue of Toxins provides current knowledge surrounding the status of botulinum toxin in functional urology and LUTDs
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    (Ab)Bilder : Zur Ideengeschichte und Ikonologie der Darstellungen menschlicher Embryonen in den Arbeiten Erich Blechschmidts (1904 – 1992) (2023)
    [Erscheinungsort nicht ermittelbar] : Universitätsverlag Göttingen
    Details
    Language: Undetermined
    Pages: 1 Online-Ressource
    Keywords: Medicine
    Abstract: Illustrations are a central component of scientific practice. They generate knowledge, shape and order it, communicate, position and discuss it at the same time. Such images, so-called epistemic images, can thus hardly be isolated from their local, social, cultural, and historical contexts. If one wants to understand the production, aesthetics, and characteristic uses of scientific images, it is necessary to take such contexts into account. The object of investigation in this thesis are the images of human embryos in the scientific work of the Göttingen anatomist Erich Blechschmidt (1904 - 1992). Initially conceived and communicated as a specialized collection, Blechschmidt's Human Embryological Documentation Collection and the images derived from it remain an anchor point for a very heterogeneous audience to this day. The work seeks explanatory approaches for the multifaceted history of the impact of Blechschmidt's images, for determining factors of their apparently enormous emotional-intuitive radiance and attraction. This is done in the sense of an iconographic-iconological analysis. The basis for this is a medical-historical investigation in the form of a reconstruction of the history of medical ideas with a focus on concepts of physiological medicine as well as a history of human embryological imaging. References to Rudolf Virchow and his cellular theory, Samuel Thomas von Soemmerring and Wilhelm His the. Ä. are presented. Translated with www.DeepL.com/Translator (free version)
    Note: German
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    The Identification of Drug Abuse (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579665 , 9783036579672
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Over the last decades, interest in forensic toxicology has continually increased. Consequently, the discipline assumed a leading role, becoming one of the reference sciences for elucidating events of judicial importance. The need to reconcile analytical problems (e.g., relating to the qualitative/quantitative analysis of substances of abuse in complex biological matrices) with judicial requirements (i.e., providing data that can be used as documentary evidence in proceedings) makes the discipline unique among all "analytical" sciences. Thus, the availability of validated procedures, the constant monitoring of analytical performance through quality assurance protocols, the availability of certified “in matrix” standards, and the analytical problems underlying the analysis of new psychoactive substances in the blood and other biological fluids represent the challenges of modern forensic toxicology. The correct interpretation of analytical data, especially to elucidate the extent of impairment induced by a certain substance, and “old” issues related to the correct interpretation of post-mortem data (given the impossibility of translating the therapeutic ranges defined in vivo) represent further areas of research and debate among scientists. Finally, the possibility of interacting with other disciplines (such as proteomics and social sciences) allows for extending the concept of analytical data acquisition/interpretation beyond the classical limits of forensic toxicology (for example, considering the influence of gender when interpreting the effect of a substance)
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    Nuts: Where We Are and Where We Are Going in Research. Proceedings from the NUTS 2022 International Conference (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036578866 , 9783036578873
    Language: Undetermined
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Humans have eaten nuts for thousands of years, yet their consumption was discouraged just a few decades ago due to their high-fat content. This perspective began to change in the early 1990s due to seminal publications from the Adventist Health Study, which showed that nut consumption significantly improved heart health-related outcomes. Many randomized clinical trials, epidemiological studies, and in vitro/in vivo mechanistic studies have since explored the role of eating nuts and its relation to health. Similarly, dried fruits have been scrutinized due to their concentrated sugar content despite their non-sodium micronutrient and fiber density. Due to accumulating evidence on nut and dried fruit intake and health outcomes, an international scientific meeting was organized for leading experts to examine and recapitulate in detail what is well known and established and what avenues of knowledge are still lacking in nut and dried fruit research. These findings highlight the beneficial health potentials of nuts for researchers, health professionals, other stakeholders, and the public while simultaneously pinpointing areas for further investigation to continue informing and guiding health practices and policies
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    On the Inequality of Lives : Inaugural Lecture delivered on Thursday 16 January 2020 (2023)
    Paris : Collège de France
    Details
    ISBN: 9782722606197
    Language: Undetermined
    Pages: 1 Online-Ressource
    Series Statement: Leçons inaugurales
    Keywords: Illness & addiction: social aspects ; Social discrimination & inequality ; Medicine
    Abstract: There is, on the one hand, life that flows from a beginning to an end, and, on the other hand, life that constitutes human singularity because it can be recounted. We may term them “biological life” and “biographical life”. Life expectancy measures the length of the former; a life story relates the richness of the latter. Only by acknowledging both can the inequality of lives be comprehended. They should be conceived of as being both distinct and connected: distinct, because the paradox of French women shows that a long life is no guarantee of a good life; connected, because the experience of African-American men stands as a reminder that a devalued life is a damaged life. This also raises the question of refugees and migrants
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    Atopic Dermatitis: Research and Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036592046 , 9783036592053
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Medicine
    Abstract: This Special Issue on Atopic Dermatitis focuses on novel insights into the pathogenesis of the immunological components of the disorder and the impaired epidermal barrier properties. It also explores the efficacy and safety of breakthrough therapies with topical agents and systemic therapies, such as monoclonals and JAK inhibitors. The aim of this Special Issue is also to present the expected future forefront of research and the treatment options that are expected to be available in the next few years
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    Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589381 , 9783036589398
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic
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    Sudden Cardiac Death: Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591988 , 9783036591995
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Sudden cardiac death (SCD) affects more than four million patients per year worldwide, and accounts for up to 50% of all cardiovascular deaths. Related to the improved treatment options for cardiovascular diseases during the past several decades (e.g., improved guideline adherence to pharmacotherapies, increasing supply with cardiac devices, and better revascularization strategies), the characteristics of patients presenting with SCD have significantly changed, making risk prediction for SCD even more complex. The present Special Issue reprint addresses the prognostic impact of patients’ characteristics (such as body mass index), airway and ventilation management in patients needing cardiopulmonary resuscitation, and the prognostic value of a targeted ambulance treatment quality improvement programme. Furthermore, the prognostic value of blood-derived biomarkers and cardiac pharmacotherapies for the prevention of SCD was investigated
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  • 63
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    Head and Neck Surgery: Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036592480 , 9783036592497
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine
    Abstract: As Guest Editors, we are very delighted to see the reprint of our Special Issue, “Head and Neck Surgery: Clinical Updates and Perspectives", which is published in the Otolaryngology section of the Journal of Clinical Medicine. These papers are the joint effort of many excellent colleagues who have devoted their lives and careers to the exciting field of Otorhinolaryngology. As both clinicians and surgeons, we are actively advancing the diagnosis and management of the myriad of conditions affecting the head and neck region. Unprecedented discoveries in the field of genetics and molecular biology are always integrated with sound knowledge of the intricate anatomy of our discipline, while technological advancements now permit us to provide tailored and minimally invasive treatments for our patients. We wish to thank all the authors who contributed to this publication and we hope you enjoy reading it
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    Recent Advances in Diagnosis and Treatment of Vestibular Disorders (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036591100 , 9783036591117
    Language: Undetermined
    Pages: 1 Online-Ressource (184 p.)
    Keywords: Medicine
    Abstract: Vestibular medicine relates to the assessment, diagnosis, and treatment of patients with dizziness and vertigo. In all these fields, there has been an enormous increase in research during recent years. This edition includes a discussion on the epidemiology of dizziness, the role of genetics in the development of vestibulopathy, diagnostic approaches, and interventions for patients with dizziness and vertigo: medical treatment, surgery, and vestibular rehabilitation
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    Aortic Aneurysms: Vascular Remodeling and Repair (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589022 , 9783036589039
    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Aortic aneurysm is a multifactorial progressive life-threatening disease. Recent surgical treatment and endovascular repair help to prevent aortic ruptures. However, there are no effective pharmacological treatments to limit aneurysm growth. This Special issue, entitled “Aortic Aneurysms: Vascular Remodeling and Repair", represents a collection of articles from innovative scientists that focuses on the recent advances in diagnostics, pathogenesis and therapies of aneurysms. This reprint includes a systematic review and nine original papers on clinical imaging, prognostic methods, genome-wide screening, novel cell signaling pathways and drug targets. We hope that readers will gain a deeper understanding of this topic and enjoy reading this reprint
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    Diagnosis, Treatment, and Management of COPD and Asthma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036589657 , 9783036589640
    Language: Undetermined
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Medicine
    Abstract: Chronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COPD is a major cause of mortality and morbidity and remains an important social problem. In the 20th century, forced expiratory volume in one second (FEV1) was the single most important measure in patients with COPD from discriminative, evaluative, and predictive standpoints. We found that dyspnea is a better mortality predictor than FEV1 in 2002 and exercise capacity in 2003. Subsequently, it has become apparent that physical activity is more predictive of mortality. Furthermore, we have recently developed the tendency to use the reduction of the future risk of exacerbation as the endpoint of relatively large-scale clinical trials rather than the improvement of FEV1. Many researchers have continued to seek better outcome markers and have also discussed what should be used as primary or secondary endpoints in clinical trials in subjects with COPD. We have undoubtedly made great progress but still have a lot of work to do for the best interests of patients
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    Gene Polymorphism and Nutrition: Relationships with Chronic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036577708 , 9783036577715
    Language: Undetermined
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Medicine
    Abstract: Studies on global human genomic variation have shown important population-based differences in allele frequencies of common single-nucleotide polymorphisms (SNPs) that influence the expression of genes related to nutrition and, secondarily, chronic disease. Some SNP sites have known functions or associations with diseases or other phenotype characteristics, including nutritional deficiencies and metabolism dietary components. There are many components of human diets that, when combined with the impact of diverse genetics on the metabolism of certain nutrients, have the capacity to give rise to harmful diet–gene interactions. This situation has the potential capacity to modify molecular phenotypes and clinical phenotypes, including human disease. Obesity, diabetes mellitus, chronobiology, osteoporosis, cancer, and many other diseases are fields of potential investigation in this topic area. This Special Issue will include manuscripts that focus on the complex relationship between gene polymorphisms and nutrition across all physiological and chronic diseases
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    Ophthalmic Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036587974 , 9783036587967
    Language: Undetermined
    Pages: 1 Online-Ressource (330 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies
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    Advances in Cardiac Electrophysiology and Pacing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590783 , 9783036590790
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Today, interventional treatment and clinical management of cardiac arrhythmias represent a continuous challenge. This is mainly due to the widening of indications for implantable electronic devices and for catheter ablation procedures as well as the continuous improvement of technologies and medical therapies. Despite international guidelines and worldwide consensus updates, evidence gaps persist at all points in the real-world setting. This Special Issue aims to provide a comprehensive overview of advances in the indications, diagnosis, and treatment of cardiac rhythm disturbances, with particular interest in the use of innovative techniques and technologies in interventional therapies
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    Diversity of Marine Fungi as a Source of Bioactive Natural Products (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591667 , 9783036591674
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Bioactive metabolites from marine-derived fungi are known to be an important source of drug discoveries. Natural product scientists have explored various environments, such as the deep ocean and polar regions, as well as marine mangrove ecosystems, to discover unique fungi strains which could produce new bioactive structures. The aim of this Special Issue is to highlight the diversity of fungi derived from different marine environments, as well as their potential as producers of bioactive marine natural products. Innovative scientific results, as well as approaches and methodologies applied in marine natural product discovery areas, are encouraged. Studies on the biosynthesis and bioactivities of marine natural products are also welcome. For this Special Issue, we invited academic and industry scientists to submit reviews and original and conceptual research articles highlighting diversified marine fungi as a source of bioactive natural products
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    Human and Planetary Health : The urgency to integrate into One Health (2023)
    Nijmegen : Radboud University Press
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    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Anthropology ; Health economics ; Health systems & services ; Health & personal development ; Medicine ; Public health & preventive medicine
    Abstract: In his professional journey, travelling through an upcoming field of surgery with apparently unlimited possibilities, Kees van Laarhoven witnessed major milestones and breakthroughs. Already as a medical student, he was amazed by surgical courage. During residency, he experienced hard work, diligence and perseverance of surgical professionals. Today as a surgeon with over 25 years of clinical experience he now looks at pieces of art in surgery with professionals compassionately bringing hope to patients.But he also sees inconvenient truths in our healthcare system, with patients evolving from one predictable and preventable disease to the next and with professionals following disease trends rather than applying their knowledge to redirect disease into health. The modern disease-oriented care system becomes undesirable and unsustainable. And there are more inconvenient truths that have progressed rather than diminished in time. Healthcare is not easily accessible to the major half of the global population and for those who have access, with a growing global population, healthcare may become unaffordable in the future. Moreover, from an environmental perspective, both human and planetary health are compromised and ask for a ‘One Health’ approach. Being fascinated by the questions of how and why did this all happen, Kees van Laarhoven took up a scientific survey to comprehend and learn how things still can be changed. He found that clear solutions are there! Please join him on his journey
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    Ciguatoxins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036564289 , 9783036564296
    Language: Undetermined
    Pages: 1 Online-Ressource (358 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
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    Biosimilars in Europe (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565750 , 9783036565743
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries
    Note: English
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    Biomaterials for Tissue Engineering and Regeneration (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563619 , 9783036563602
    Language: Undetermined
    Pages: 1 Online-Ressource (366 p.)
    Keywords: Medicine
    Abstract: Biomaterials are an integral component of tissue engineering, and their development is crucial to the progress of new and efficient approaches in the regenerative medicine of bone, cartilage, tendons and ligaments, skin, soft-tissue wounds, cardiac muscle, vascular tissues, and neural tissues.Polymer-based biomaterials are extensively studied in the field of tissue engineering due to their biocompatible and biodegradable properties. This Special Issue is devoted to recent developments of synthetic and/or natural biomaterial scaffolds, hydrogels, polypeptides, polymer-based composites, and composites based on polymers and inorganic materials, such as bioactive ceramics and glasses. New technologies (e.g., bioprinting, additive manufacturing, etc.) used to form biomaterials for tissue engineering of three-dimensional (3D) constructs are of particular interest
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  • 75
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    Spectroscopic, Thermodynamic and Molecular Docking Studies on Molecular Mechanisms of Drug Binding to Proteins (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562261 , 9783036562254
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated
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    Molecular Mechanisms and Therapies of Colorectal Cancer (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565477 , 9783036565460
    Language: Undetermined
    Pages: 1 Online-Ressource (294 p.)
    Keywords: Medicine ; Oncology
    Abstract: Colorectal cancer (CRC) is currently the third leading cause of cancer-related mortality, with 1.9 million incidence cases and 0.9 million deaths worldwide. The global number of new CRC cases is predicted to reach 3.2 million in 2040, based on the projection of aging, population growth, and human development.In clinics, despite advances of diagnosis and surgical procedures, 20% of the patients with CRC present with metastasis at the time of diagnosis, caused by residual tumor cells that have spread to distant organs prior to surgery, affecting the patient survival rate. Standard systemic chemotherapy, alternative therapies that target mechanisms involved in cancer progression and metastasis, immunotherapy, and combination therapies are the major CRC-treatment strategies. In the advanced stage of CRC the transforming growth factor-beta (TGF-β) plays an oncogenic role by promoting cancer cell proliferation, cancer cell self-renewal, epithelial-to-mesenchymal transition, invasion, tumor progression, metastatic spread, and immune escape. Furthermore, high levels of TGF-β1 confers poor prognosis and is associated with early recurrence after surgery, resistance to chemo- or immunotherapy, and shorter survival. Based on the body of experimental evidence indicating that TGF-β signaling has the potential to be a good therapeutic target in CRC, several anti-TGF-β drugs have been investigated in cancer clinical trials. Here, we presented a comprehensive collection of manuscripts regarding studies on targeting the TGF-β signaling in CRC to improve patient’s prognosis and personalized treatments
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  • 77
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    Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563183 , 9783036563190
    Language: Undetermined
    Pages: 1 Online-Ressource (296 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories
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    Research on Pathogenic Fungi and Mycotoxins in China (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036562698 , 9783036562704
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins
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  • 79
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    Biomaterials for Bone Tissue Engineering 2020 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036561042 , 9783036561035
    Language: Undetermined
    Pages: 1 Online-Ressource (242 p.)
    Keywords: Medicine
    Abstract: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration
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  • 80
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    Advanced Blood-Brain Barrier Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036564173 , 9783036564166
    Language: Undetermined
    Pages: 1 Online-Ressource (496 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Advanced Blood-Brain Barrier Drug Delivery is a reprint with a summary editorial, followed by 16 chapters that cover five areas of brain drug delivery, including receptor-mediated transport (RMT), carrier-mediated transport (CMT), active efflux transport (AET), Trojan horse lipid nanoparticles (LNP), and in vivo methods for measurement of drug transport across the blood–brain barrier (BBB)
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    In Silico Strategies for Prospective Drug Repositionings (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036561349 , 9783036561332
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions
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    Endocrine and Neuroendocrine Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036557632 , 9783036557649
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine ; Oncology
    Abstract: Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available. This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives
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    Parasites and Wildlife (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568522 , 9783036568539
    Language: Undetermined
    Pages: 1 Online-Ressource (174 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: This reprint focuses on field studies aimed at unraveling the complex networks created by interactions between parasites and hosts in a given ecosystem. Since most transboundary diseases have been propagated from the wilderness to anthropized areas, societies are increasingly concerned about the relevance of wildlife as it pertains to global health. In this respect, research on parasites that may affect the biology and population equilibrium of wildlife is of major interest, especially when a One Health perspective is considered. The studies compiled in the present Special Issue fall within several areas of interest, such as epidemiology, diagnosis, emerging zoonoses, food safety, conservation issues, parasite–host interactions, and the pathology of infections caused by parasites in wild host species
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    Challenges and Opportunities for Effective Cancer Immunotherapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036569604 , 9783036569611
    Language: Undetermined
    Pages: 1 Online-Ressource (500 p.)
    Keywords: Medicine
    Abstract: Anti-cancer immunotherapies have generated spectacular outcomes in the clinical environment and changed treatment schemes for cancer patients. Adoptive cell therapies (ACTs), including using autologous tumor-infiltrating lymphocytes and chimeric antigen receptor (CAR) T cells, and checkpoint blockades have emerged as the most effective treatments for certain cancers. The current challenge for cancer immunotherapies is that although some patients have benefited from the treatments, a number of cancers are resistant. The purpose of this Special Issue is to understand anti-cancer immunotherapy treatment resistance mechanisms and explore new options to provide opportunities for effective treatments
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    3D Printed Materials Dentistry (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568881 , 9783036568898
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine ; Pharmacology ; Research & information: general ; Chemistry
    Abstract: The Special Issue reprint covers a wide range of applications of 3D-printing in dentistry. Five out of eleven research papers deal with applications of 3D printing in orthodontics, one study presents a 3D-printed fitting system for the FFP2 that were applied during the COVID-19 pandemic, and the others address applications in prosthodontics and restorative dentistry
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    Molecular Mechanisms of Steroid Hormone Biosynthesis and Action (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570037 , 9783036570020
    Language: Undetermined
    Pages: 1 Online-Ressource (360 p.)
    Keywords: Medicine
    Abstract: Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the “Molecular mechanisms of steroid hormone biosynthesis and action” of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones
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    Personalized and Precision Medicine 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570457 , 9783036570440
    Language: Undetermined
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Medicine
    Abstract: This reprint, guest edited by Anne-Marie Caminade, gives an impressionist overview of the current state of the art about “Personalized and Precision Medicine”. Twenty contributions illustrate the diversity of the topic, including new approaches about cancers, neurodegenerative diseases, infectious diseases, lungs obstruction, skeletal diseases, intestinal microbiomes, new tools such as ultra-high-frequency ultrasound or non-oncological radiotherapy, and a new class of drugs (dendrimers). This reprint is an illustration of the present and future impact of Personalized and Precision Medicine on all the therapeutic domains
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    Angiogenesis in Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036569161 , 9783036569178
    Language: Undetermined
    Pages: 1 Online-Ressource (274 p.)
    Keywords: Medicine ; Oncology
    Abstract: Tumor progression is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors. Inflammatory infiltration contributes to tumor progression and metastatic process, and there are many reports of associations between tumor inflammatory infiltration, progression and prognosis. New therapeutic approaches have been developed with the aim to control tumor progression through the targeting of different components of the tumor microenvironment. This reprint will be useful for anyone who wants to learn about cancer: professors and students at universities, scientists at research institutes, biotechnology, and pharmaceutical labs, and lawyers trying to understand the patent literature
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    Advances in Neuroimaging Data Processing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036569987 , 9783036569994
    Language: Undetermined
    Pages: 1 Online-Ressource (186 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications
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    Artificial Intelligence in Cancer Diagnosis and Therapy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566726 , 9783036566733
    Language: Undetermined
    Pages: 1 Online-Ressource (672 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint covers some significant impacts in the recent research in both the private and public sectors of cancer diagnosis and therapy, in which Artificial Intelligence (AI) and Machine Learning are significant. This reprint is also a collection of forty different complex and challenging problems arranged in five groups: AI in prognosis, grading, and prediction, AI in clinical image analysis, AI models for pathological diagnosis, ML and statistical models for molecular cancer diagnostics and genetics, and AI in triage, risk stratification, and screening cancer, which are all focused on using AI in cancer diagnosis and therapy. All the necessary concepts, solutions, methodologies, and references are supplied except for some fundamental knowledge that is well-known in the general fields of AI and cancer diagnosis and therapy. The readers may, therefore, gain the main concepts of each chapter, with as little of a need as possible to refer to the concepts of the other chapters and references. The readers may hence start to read one or more chapters of the book for their own interests
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    Novel Anticancer Strategies (Volume II) (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570334 , 9783036570327
    Language: Undetermined
    Pages: 1 Online-Ressource (700 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells
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  • 92
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    Model-Informed Precision Dosing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568966 , 9783036568973
    Language: Undetermined
    Pages: 1 Online-Ressource (320 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs
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    Tryptophan in Nutrition and Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570778 , 9783036570761
    Language: Undetermined
    Pages: 1 Online-Ressource (324 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society
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    Immunohistochemical and Physiological Research on Farm Animals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568829 , 9783036568836
    Language: Undetermined
    Pages: 1 Online-Ressource (318 p.)
    Keywords: Medicine
    Abstract: This reprint represents a collection of papers that aimed to highlight the importance of immunohistochemical findings and their role in improving the understanding of organ tissue functions. We focused our attention on farm animals because they represent not only a source of food in the supply chain, but also a source of income for breeders, a source of employment, and a primary tool in the quest for sustainable food production. To achieve this last aim, we asked authors for research that could potentially be applied to the purpose of this study, and whose results could be useful in improving farm management practices and the responsible use of natural resources. A total of 20 papers were contributed to this issue, written by 118 authors from 4 countries, and comprising 18 research articles and 2 communications articles
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    Nutrition at the Interface of Sleep and Circadian Rhythms: Implications for Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036567082 , 9783036567099
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: An integral part of homeostasis includes daily rhythms in physiology, behavior, and metabolism. The circadian timing system enables organisms to adapt their biological functions to the cyclic nature of the Earth. Sleep is a fundamental physiological function, playing a crucial role in physical, mental and emotional health. Alterations of sleep quality and quantity caused by modern lifestyle and behavior as well sleep disorders are associated with an increased risk for chronic diseases. Chronic misalignment of endogenous rhythms can also lead to metabolic dysfunction. Research is starting to demonstrate the complex interrelationship between nutrition, sleep and the circadian system. For example, some foods and nutrients may impact the availability of substances that influence sleep. On the other hand, inadequate sleep is associated with an unhealthy nutrient intake and altered metabolism. Nutrients can act as drivers of circadian rhythms; they have the ability to influence circadian regulation and alter biological functions in specific tissues. A lacuna still exists in the knowledge surrounding the interplay of nutrition with sleep and the circadian system. In light of this, novel opportunities are disclosed for developing tailored nutritional recommendations with beneficial effects on sleep and circadian rhythmicity so as to improve life quality and prevent disease. The purpose of this Special Issue is therefore to collect contributions regarding this interplay and the related clinical implications
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    Agricultural Products Processing and Postharvest Storage (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574165 , 9783036574172
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Agricultural products such as fruit, vegetables, and cereal are believed to be some of the most crucial sources of certain phytonutrients necessary for humans, such as vitamins, dietary fibers, and minerals. However, agricultural products are prone to quality deterioration during storage under ambient temperatures. Currently, the annual post-harvest loss rate of agricultural products can reach up to 20–30%. Owing to their perishable nature, the development of processing and preservation technologies for agricultural products is an important research topic closely associated with the national economy and people’s livelihoods that has attracted ever-increasing attention. In view of the prominent issues of high energy consumption, high costs, serious pollution, and low-quality properties in agricultural product manufacturing, our journal mainly focuses on research articles on novel techniques and the underlying mechanisms of the processing, preservation, and quality control of agricultural products, so as to promote the upgrading and updating of the agricultural product industry
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  • 97
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    Thrombolysis and Thrombectomy in Acute Ischemic Stroke (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036575988 , 9783036575995
    Language: Undetermined
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke
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    Functional Foods as a New Therapeutic Strategy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036577081 , 9783036577098
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 99
    Online Resource
    Online Resource
    Novel Approaches for Overcoming Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576992 , 9783036576985
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery
    Note: English
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
  • 100
    Online Resource
    Online Resource
    The Role of Toll-Like Receptors (TLR) in Infection and Inflammation (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036576152 , 9783036576145
    Language: Undetermined
    Pages: 1 Online-Ressource (236 p.)
    Keywords: Medicine
    Abstract: Toll-like receptors (TLRs) represent a powerful system for the recognition and elimination of pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and other pathogens and damage-associated molecular patterns (DAMPs) released from dying cells. Typical PAMPs include bacterial cell wall components, viral pathogens, or pathogenic nucleic acids, including viral RNA and DNA. Activation of TLRs leads to the production of proinflammatory cytokines and type I interferons which are important for the induction of the host immune response against bacterial and viral infections. However, dysregulation and overstimulation can be detrimental, leading to hyper-inflammation, sepsis, and loss of tissue integrity. The involvement of TLRs in inflammation and bacterial infection has been recognized for a long time. There is an increasing number of reports demonstrating the involvement of TLR activation in a variety of viral infections, associated with protective immunity, but also immune hyper activation and even viral replication. Recent data show the involvement of TLR activation in various acute respiratory viral infections, including SARS-CoV-2 and indicate an essential role in COVID-19 pathology. It aimed to gather newest data and hypotheses regarding molecular and cellular mechanisms of TLR triggering and activation and their downstream signaling pathways by viral infections, and their correlation to immunology and pathophysiology of the associated diseases, to facilitate translational research resulting in new targets for the treatment of viral infectious diseases including COVID-19
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
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