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  • MPI Ethno. Forsch.  (307)
  • FID-SKA-Lizenzen
  • 2015-2019  (307)
  • 1960-1964
  • 2017  (307)
  • [Erscheinungsort nicht ermittelbar] : Frontiers Media SA  (307)
Datasource
  • MPI Ethno. Forsch.  (307)
  • FID-SKA-Lizenzen
Material
Language
Years
  • 2015-2019  (307)
  • 1960-1964
Year
Author, Corporation
Publisher
  • 1
    Online Resource
    Online Resource
    Sleep Spindles: Breaking the Methodological Wall (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451166
    Language: English
    Pages: 1 Online-Ressource (228 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the last decade, sleep spindles have attracted steadily increasing attention. This interest is motivated by the many intriguing relationships between spindles and various diseases (e.g., schizophrenia, Parkinson, Alzheimer, autism, mental retardation), recovery processes (e.g., post brain stroke), and cognitive faculties (e.g., memory consolidation, intelligence, dream recall, sleep preservation). Nonetheless, a methodological wall has impeded the study of sleep spindles. Their investigation rests heavily on our ability to reliably and consistently identify spindle patterns from background EEG activity, a task involving many obstacles, including: a fuzzy definition of spindles, low inter-expert agreement on their scoring, lack of consensus on standard techniques for their automated detection, low reproducibility of observed characteristics and correlates, unavailability of large, standardized, high-quality databases, and inconsistencies in the methods used to evaluate the performance of automated detectors. The primary aims of this research topic were to bring together world-class researchers on a project designed to facilitate exchanges on methodological difficulties encountered in assessing sleep spindles and to promote standardized spindle-related resources. In preparing their contributions, authors were encouraged to use existing – or to propose new – publicly available resources for assessing sleep spindles. To allow fair and accurate comparison of reported results, the authors were also encouraged to validate their tools on a common benchmark. A database containing expert spindle scoring (i.e., the Montreal Archive of Sleep Studies) was made publicly available for that purpose
    Note: English
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  • 2
    Online Resource
    Online Resource
    Signaling in the Phytomicrobiome (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889452163
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: A plant growing under field conditions is not a simple individual; it is a community. We now know that there is a community of microbes associated with all parts of the plant, and that the root associated community is particularly large. This microbial community, the phytomicrobiome, is complex, regulated and the result of almost half a billion years of evolution. Circumstances that benefit the plant generally benefit the phytomicrobiome, and vice versa. Members of the holobiont modulate each other's activities, in part, through molecular signals, acting as the hormones of the holobiont. The plant plus the phytomicrobiome constitute the holobiont, the resulting entity that is that community. The phytomicrobiome is complex, well developed and well-orchestrated, and there is considerable potential in managing this system. The use of “biologicals” will develop during the 21st century and play as large a role as agro-chemistry did in the 20th century. Biologicals can be deployed to enhance plant pathogen resistance, improve plant access to nutrients and improve stress tolerance. They can be used to enhance crop productivity, to meet the expanding demands for plant material as food, fibre and fuel. They can assist crop plants in dealing with the more frequent and more extreme episodes of stress that will occur as climate change conditions continue to develop. The path is clear and we have started down it; there is a considerable distance remaining
    Note: English
    URL: kostenfrei
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  • 3
    Online Resource
    Online Resource
    Sound, Music and Movement in Parkinson's Disease (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889450794
    Language: English
    Pages: 1 Online-Ressource (176 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Recent years have brought new insights to the understanding of Parkinson’s disease, impact of exercise and sound displays in rehabilitation and movement facilitation. There is growing evidence that auditory signals in the environment can provide a temporal template for movement and change the mode of motor control from intrinsic to extrinsic; habitual to goal-directed, enabling enhanced motor performance in patients. In addition, forced exercise rate studies show that exercising at the pace of healthy adults can have potential neuroprotective benefits for patients. Many research groups have explored the use of auditory cues (such as rhythmical auditory training) in improving gait and upper limb movement parameters. Cues are usually either intermittent (metronome) or continuous (dynamic sound displays). Similarly, dance based interventions suggest that patients benefit from additional sensory information (i.e. the temporal structure embedded in music and proprioceptive information from a dancing partner) that facilities movement. On the contrary, studies dedicated to auditory perception and motor timing report an impaired ability of patients to perceive and synchronise with complex rhythmical structures (i.e. causing an inability to play musical instruments). With the growth of modern technology and the increasing portability of hi-specification devices (such as smart phones), new research questions on the design of interventions are beginning to emerge as we strive for more efficient therapeutic approaches. In this Research Topic we wanted to bring together top scientists from the movement disorder, motor control and sound related studies along with therapists. That way, we can engage in cross-disciplinary and challenging scientific debate about future rehabilitation avenues and frontiers for Parkinson’s disease patients
    Note: English
    URL: kostenfrei
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  • 4
    Online Resource
    Online Resource
    Social Interaction in Animals: Linking Experimental Approach and Social Network Analysis (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451227
    Language: English
    Pages: 1 Online-Ressource (123 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Understanding the link between individual behaviour and population organization and functioning has long been central to ecology and evolutionary biology. Behaviour is a response to intrinsic and extrinsic factors including individual state, ecological factors or social interactions. Within a group, each individual can be seen as part of a network of social interactions varying in strength, type and dynamic. The structure of this network can deeply impact the ecology and evolution of individuals, populations and species. Within a group social interactions can take many forms and may significantly affect an individual’s fitness. These interactions may result in complex systems at the group-level, such as in the case of collective decisions (to migrate, to build nest or to forage). Among them, social transmission of information has been studied mostly in vertebrates: fish, birds and mammals including humans. In insects, social learning has been unambiguously demonstrated in social Hymenoptera but this probably reflects limited research effort and recent evidence show that even non-eusocial insects such as Drosophila, cockroaches and crickets can copy the behaviour of others. Compared to individual learning, which requires a trial and error period every generation, social learning can potentially result in the stable transmission of behaviours across generations, leading to cultural traditions in some species. The study of the processes which may facilitate or prevent this transmission and the analyses of the relationship between social network structure and efficiency of social transmission became these recent years an emerging and promising field of research. The goal of this research topic is to present the genetic and socio-environmental factors affecting social interaction and information or pathogen transmission with the integration of experimental approaches, social network analyses and modelling. Importantly, we aim to understand whether a relationship between social network structures and dynamics can reflect the efficiency of social transmission, i.e. can we use social network analysis to predict the social transmission of information or of pathogen, collective decision-making and ultimately the evolutionary trajectory of a group?
    Note: English
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  • 5
    Online Resource
    Online Resource
    The Reasoning Brain: The Interplay between Cognitive Neuroscience and Theories of Reasoning (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451180
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Despite the centrality of ...
    Note: English
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  • 6
    Online Resource
    Online Resource
    Redox Regulation in Skeletal Muscle Aging and Exercise (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451968
    Language: English
    Pages: 1 Online-Ressource (101 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Skeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise
    Note: English
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  • 7
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    Online Resource
    Re-Enacting Sensorimotor Experience for Cognition (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451487
    Language: English
    Pages: 1 Online-Ressource (163 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Mastering the sensorimoto ...
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  • 8
    Online Resource
    Online Resource
    Principles of Hip Arthroscopy (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889452507
    Language: English
    Pages: 1 Online-Ressource (89 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The field of arthroscopy, originating from Denmark in 1912, has rapidly evolved to diagnose and treat a wide range of musculoskeletal pathologies. Although around for sometime, arthroscopy in the field of orthopedics has traditionally focused on the knee, shoulder, or elbow, as arthroscopy of the hip is technically challenging; the deep structures of the hip, including neurovascular bundles, require specialized training and equipment to access. However, with advances in surgical techniques, hip arthroscopy has become increasingly popular given its ability to treat pathologies with previously poor prognoses such as labral tears, hip arthritis and femoroacetabular impingement (FAI). When indicated, hip arthroscopy results in shorter recovery times, low complication rates, and excellent outcomes in quality of life and pain regardless of age, gender or activity level. The purpose of this e-book is to shed light on this expanding field by delving into the common hip pathology femoroacetabular impingement, its clinical relevance, and to explore various surgical techniques and postoperative rehabilitation. It is our hope that this textbook provides valuable knowledge to advance the field of hip arthroscopy, enhance surgical techniques, and ultimately increase the quality of patient care
    Note: English
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  • 9
    Online Resource
    Online Resource
    Proteomics of Microbial Human Pathogens (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889450886
    Language: English
    Pages: 1 Online-Ressource (152 p.)
    Series Statement: Frontiers Research Topics
    Abstract: According to the World He ...
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  • 10
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    Recent Advances in Acidophile Microbiology: Fundamentals and Applications (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451630
    Language: English
    Pages: 1 Online-Ressource (155 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There is considerable interest in pure and applied studies of extremophilic microorganisms, including those (acidophiles) that are active in low pH environments. As elsewhere in microbiology, this is a fast-developing field, and the proposed special issue of Frontiers highlights many of the more recent advances that have been made in this area. Authors from leading scientific groups located in North and South America, Australasia and Europe have contributed to this e-book, and the topics covered include advances in molecular, biochemical, biogeochemical and industrial aspects of acidophile microbiology
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  • 11
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    Online Resource
    The Role of the Plasminogen Activating System in Neurobiology (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889450633
    Language: English
    Pages: 1 Online-Ressource (132 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This ebook contains a series of original publications, reviews and mini-reviews by leaders in the field that address the growing importance of the plasminogen activating system in neurobiology. The articles included cover the role of the plasminogen activating system as a key modulator of blood brain barrier permeability, and the implications of this in traumatic brain injury and in ischemic stroke. State-of-the-Art manuscripts are also included that address the regulatory mechanisms that control this important process.This ebook contains a series of original publications, reviews and mini-reviews by leaders in the field that address the growing importance of the plasminogen activating system in neurobiology. The articles included cover the role of the plasminogen activating system as a key modulator of blood brain barrier permeability, and the implications of this in traumatic brain injury and in ischemic stroke. State-of-the-Art manuscripts are also included that address the regulatory mechanisms that control this important process
    Note: English
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  • 12
    Online Resource
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    The Role of Microbial Communities in Tropical Ecosystems (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889450671
    Language: English
    Pages: 1 Online-Ressource (173 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Tropical ecosystems are different in important ways from those of temperate regions. They are a major reservoir of plant and animal biodiversity and play important roles in global climate regulation and biogeochemical cycling. They are also under great threat due to the conversion of tropical ecosystems to other uses. Thus, in the context of global change, it is crucial to understand how environmental factors, biogeographic patterns, and land use changes interact to influence the structure and function of microbial communities in these ecosystems. The contributions to this Research Topic showcase the current knowledge regarding microbial ecology in tropical ecosystems, identify many challenges and questions that remain to be addressed and open up new horizons in our understanding of the environmental and anthropological factors controlling microbial communities in these important ecosystems.Tropical ecosystems are different in important ways from those of temperate regions. They are a major reservoir of plant and animal biodiversity and play important roles in global climate regulation and biogeochemical cycling. They are also under great threat due to the conversion of tropical ecosystems to other uses. Thus, in the context of global change, it is crucial to understand how environmental factors, biogeographic patterns, and land use changes interact to influence the structure and function of microbial communities in these ecosystems. The contributions to this Research Topic showcase the current knowledge regarding microbial ecology in tropical ecosystems, identify many challenges and questions that remain to be addressed and open up new horizons in our understanding of the environmental and anthropological factors controlling microbial communities in these important ecosystems
    Note: English
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  • 13
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    Online Resource
    The Role of Primary Motor Cortex as a Marker for and Modulator of Pain Control and Emotional-Affective Processing (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889452613
    Language: English
    Pages: 1 Online-Ressource (169 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The sensory and motor cortical homunculi proposed by Walter Penfield were a major landmark for the anatomical mapping of the brain. More than 60 years after, the development of new tools to investigate brain function non-invasively has increased our knowledge about the structure and functions of the primary motor Cortex (M1) beyond motor control in both humans and animals. This book highlights the role of the motor cortex that goes way beyond motor functioning. We were interested in both theoretical and empirical contributions related to electrophysiological, pharmacological, neuroimaging, and neuromodulatory studies exploring the role of M1 on non-motor functions, such as pain, abnormal neuroplasticity that may lead to chronic pain conditions; or the relationship between M1 and mental imagery or emotion. This book is comprised of 15 articles published in this edited volume as a research topic collection in Frontiers in Human Neuroscience titled “The Role of Primary Motor Cortex as a Marker and Modulator of Pain Control and Emotional-Affective Processing.”
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  • 14
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    MAPPING MAnagement and Processing of images for Population ImagiNG (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889452606
    Language: English
    Pages: 1 Online-Ressource (139 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Several recent papers und ...
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  • 15
    Online Resource
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    Models of Reference (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451609
    Language: English
    Pages: 1 Online-Ressource (243 p.)
    Series Statement: Frontiers Research Topics
    Abstract: To communicate, speakers need to make it clear what they are talking about. Referring expressions play a crucial part in achieving this, by anchoring utterances to things. Examples of referring expressions include noun phrases such as “this phenomenon”, “it” and “the phenomenon to which this Topic is devoted”. Reference is studied throughout the Cognitive Sciences (from philosophy and logic to neuro-psychology, computer science and linguistics), because it is thought to lie at the core of all of communication. Recent years have seen a new wave of work on models of referring, as witnessed by a number of recent research projects, books, and journal Special Issues. The Research Topic “Models of Reference” in Frontiers in Psychology is a new milestone, focusing on contributions from Psycholinguistics and Computational Linguistics. The articles in it are concerned with such issues as audience design, overspecification, visual perception, and variation between speakers
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  • 16
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    Mitochondria in Skeletal Muscle Health, Aging and Diseases (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889450732
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Skeletal muscle is the mo ...
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  • 17
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    Online Resource
    Microbiota of Grapes: Positive and Negative Role on Wine Quality (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451210
    Language: English
    Pages: 1 Online-Ressource (231 p.)
    Series Statement: Frontiers Research Topics
    Abstract: During spontaneous food/b ...
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  • 18
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    Mental State Understanding: Individual Differences in Typical and Atypical Development (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889452682
    Language: English
    Pages: 1 Online-Ressource (203 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The current book addresses the development of mental state understanding in children with typical and atypical population, and reports new suggestions about the way to evaluate it and to support it through training. The presented frame is multifaceted. In respect to typical populations, the role of maternal reflective functioning, language, communication, and educational contexts has been deepened; and the association with internalizing/externalizing behaviors, performances in spatial tasks and pragmatics has been addressed as well. As to atypical populations, deficits in mental states understanding are reported for children with different developmental disorders or impairments, as the agenesis of the corpus callosum, Down Syndrome, preterm birth, Autism Spectrum Disorder, hearing impairment and personality difficulties such as anxiety. Overall, the papers collected in our book allow a better understanding of the mechanisms influencing mental state understanding and the effects of mental state comprehension on development
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  • 19
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    Magnetic Records of Extreme Geological Events (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889451708
    Language: English
    Pages: 1 Online-Ressource (86 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Recent advances in environmental magnetism offer the opportunity to link the magnetic signature of marine and continental rocks to the paleoenvironmental and paleoclimatic settings that controlled their formation or deposition, as well as to post-depositional events, such as diagenesis, that can alter their primary signature. This Research Topic assembles studies that used state of the art rock magnetic techniques to unravel the causes and effects of catastrophic geological events, including tsunami, meteorite impacts, Archean oxygenation event, geomagnetic reversals, and global climate changes linked to large volcanic eruptions
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  • 20
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    Microbial Food Safety Along The Dairy Chain (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889453122
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The dairy chain is an integral part of global food supply, with dairy food products a staple component of recommended healthy diets. The dairy food chain from production through to the consumer is complex, with various opportunities for microbial contamination of ingredients or food product, and as such interventions are key to preventing or controlling such contamination. Dairy foods often include a microbial control step in their production such as pasteurization, but in some cases may not, as with raw milk cheeses. Microbial contamination may lead to a deterioration in food quality due to spoilage organisms, or may become a health risk to consumers should the contaminant be a pathogenic microorganism. As such food safety and food production are intrinsically linked. This Research Topic eBook includes submissions on issues relating to the microbiological integrity of the dairy food chain, such as the ecology of pathogenic and spoilage organisms through the dairy farm to fork paradigm, their significance to dairy foods and health, and genomic analysis of these microorganisms
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  • 21
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    A Matter of Bottom-Up or Top-Down Processes: The Role of Attention in Multisensory Integration (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451937
    Language: English
    Pages: 1 Online-Ressource (139 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The integration of information from various sensory modalities influences behaviour. It can induce behavioural benefits such as faster reaction times and enhanced detection of noisy signals but may also produce illusions, all of which have been characterized by specific neuronal signatures. Yet, while these effects of multisensory integration are largely accepted, the role of attention in this process is still the object of intense debate. On the one hand, it has been suggested that attention may guide multisensory integration in a top-down fashion by selection of specific inputs to be integrated out of the plethora of information in our environment. On the other hand, there is evidence that integration could occur in a bottom-up manner, based on temporal and spatial correlations, and outside the focus of attention. An extreme example is the multisensory enhancement of neural responses in anesthetised animals. Attention itself is not a unitary construct, and may refer to a range of different selection mechanisms. Therefore, the interplay between attention and multisensory integration can take many forms which explain, in part, the diversity of findings and the disputes in the literature. The goal of this Research Topic is to help clarify the picture by trying to answer the following questions from various perspectives: Under which circumstances does multisensory integration take place without attention?, and, When does attention determine the fate of multisensory integration?
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  • 22
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    Mechanisms Underpinning the Link between Emotion, Physical Health and Longevity (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452743
    Language: English
    Pages: 1 Online-Ressource (185 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The 1990’s was designated as ‘the decade of the brain’ and now, common mental disorders are described as ‘brain disorders’. Yet intense research interest on the brain has largely side-lined the body as a passive observer, disconnecting mental from physical health and contributing to further societal stigma on the nature of psychiatric illness and mental distress. The biopsychosocial pathway to premature mortality or longevity is a complex one, involving a host of closely intertwined mechanisms and moderating factors, some of which are investigated in this special issue. All the articles published here provide new insights into the pathways linking emotion, physical health and longevity, highlighting the tight linkage between mind, brain and body
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  • 23
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    Phonology in the Bilingual and Bidialectal Lexicon (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452101
    Language: English
    Pages: 1 Online-Ressource (185 p.)
    Series Statement: Frontiers Research Topics
    Abstract: A conversation between two people can only take place if the words intended by each speaker are successfully recognized. Spoken word recognition is at the heart of language comprehension. This automatic and smooth process remains a challenge for models of spoken word recognition. Both the process of mapping the speech signal onto stored representations for words, and the format of the representation themselves are subject to debate. So far, existing research on the nature of spoken word representations has focused mainly on native speakers. The picture becomes even more complex when looking at spoken word recognition in a second language. Given that most of the world’s speakers know and use more than one language, it is crucial to reach a more precise understanding of how bilingual and multilingual individuals encode spoken words in the mental lexicon, and why spoken word recognition is more difficult in a second language than in the native language. Current models of native spoken word recognition operate under two assumptions: (i) that listeners’ perception of the incoming speech signal is optimal; and (ii) that listeners’ lexical representations are accurate. As a result, lexical representations are easily activated, and intended words are successfully recognized. However, these assumptions are compromised when applied to a later-learned second language. For a variety of reasons (e.g., phonetic/phonological, orthographic), second language users may not perceive the speech signal optimally, and they may still be refining the motor routines needed for articulation. Accordingly, their lexical representations may differ from those of native speakers, which may in turn inhibit their selection of the intended word forms. Second language users also have to solve a larger selection challenge—having words in more than one language to choose from. Thus, for second language users, the links between perception, lexical representations, orthography, and production are all but clear. Even for simultaneous bilinguals, important questions remain about the specificity and interdependence of their lexical representations and the factors influencing cross-language word activation. This Frontiers Research Topic seeks to further our understanding of the factors that determine how multilinguals recognize and encode spoken words in the mental lexicon, with a focus on the mapping between the input and lexical representations, and on the quality of lexical representations
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  • 24
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    Plant immunity against viruses (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452699
    Language: English
    Pages: 1 Online-Ressource (163 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Plant viruses impose a serious threat on agriculture, which motivates extensive breeding efforts for viral resistant crops and inspires lasting interests on basic research to understand the mechanisms underlying plant immunity against viruses. Viruses are obligate intracellular parasites. Their genomes are usually small and only encode a few products that are essential to hijack host machinery for their nucleotide and protein biosynthesis, and that are necessary to suppress host immunity. Plants evolved multilayers of defense mechanisms to defeat viral infection. In this research topic, we gathered 13 papers covering recent advances in different aspects of plant immunity against viruses, including reviews on RNA silencing and R gene based immunity and their application, translational initiation factor mediated recessive resistance, genome editing based viral immunity, role of chloroplast in plant-virus interaction, and research articles providing new mechanistic insights on plant-virus interactions. We hope that this Research Topic helps readers to have a better understanding of the progresses that have been made recently in plant immunity against viruses. A deeper understanding of plant antiviral immunity will facilitate the development of innovative approaches for crop protections and improvements
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    Personality and Cognition in Economic Decision Making (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452361
    Language: English
    Pages: 1 Online-Ressource (232 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Psychologists studying cognitive processes and personality have increasingly benefited from the wealth of theory, methodology, and decision making paradigms used in economics and game theory. Similarly, for the economists, personality traits and basic cognitive processes offer a set of coherent explanatory constructs in economic behavior. Given the debate on preference invariance and behavioral consistency across contexts and domains, the papers in this topic shed light on the existence and effect of stable sets of idiosyncratic features on economic decision-making. While the effects of personality and cognition on economic decisions remain under-explored, the papers contributed in this topic offer more than a stimulus for further research. The general message could be that personality and cognitive processes offer the stable idiosyncratic ground on which individual decisions are made
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    Plant Organ Abscission: From Models to Crops (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453283
    Language: English
    Pages: 1 Online-Ressource (271 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Plant organ abscission is a developmental process regulated by the environment, stress, pathogens and the physiological status of the plant. In particular, seed and fruit abscission play an important role in seed dispersion and plant reproductive success and are common domestication traits with important agronomic consequences for many crop species. Indeed, in natural populations, shedding of the seed or fruit at the correct time is essential for reproductive success, while for crop species the premature or lack of abscission may be either beneficial or detrimental to crop productivity. The use of model plants, in particular Arabidopsis and tomato, have led to major advances in our understanding of the molecular and cellular mechanisms underlying organ abscission, and now many workers pursue the translation of these advances to crop species. Organ abscission involves specialized cell layers called the abscission zone (AZ), where abscission signals are perceived and cell separation takes place for the organ to be shed. A general model for plant organ abscission includes (1) the differentiation of the AZ, (2) the acquisition of AZ cells to become competent to respond to various abscission signals, (3) response to signals and the activation of the molecular and cellular processes that lead to cell separation in the AZ and (4) the post-abscission events related to protection of exposed cells after the organ has been shed. While this simple four-phase framework is helpful to describe the abscission process, the exact mechanisms of each stage, the differences between organ types and amongst diverse species, and in response to different abscission inducing signals are far from elucidated. For an organ to be shed, AZ cells must transduce a multitude of both endogenous and exogenous signals that lead to transcriptional and cellular and ultimately cell wall modifications necessary for adjacent cells to separate. How these key processes have been adapted during evolution to allow for organ abscission to take place in different locations and under different conditions is unknown. The aim of the current collection of articles is to present and be able to compare recent results on our understanding of organ abscission from model and crop species, and to provide a basis to understand both the evolution of abscission in plants and the translation of advances with model plants for applications in crop species
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    Origin of Tropical Diversity: From Clades to Communities (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450503
    Language: English
    Pages: 1 Online-Ressource (282 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In this volume we aimed to assess progress in determining the processes by which current patterns of tropical biodiversity were established and are maintained. Tropical regions are highly species-rich and we present studies that have improved our understanding of the generation of that diversity at local, regional and global scales. We demonstrate how diverse fields from molecular phylogenetics, phylogeography, palaeontology and palaeoecology continue to improve our understanding of the natural history of the tropics
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    Plant Responses to Biotic and Abiotic Stresses: Lessons from Cell Signaling (2017)
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    ISBN: 9782889453566
    Language: English
    Pages: 1 Online-Ressource (298 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Facing stressful conditions imposed by their environment and affecting their growth and their development throughout their life cycle, plants must be able to perceive, to process and to translate different stimuli into adaptive responses. Understanding the organism-coordinated responses involves a fine description of the mechanisms occurring at the cellular and molecular level. A major challenge is also to understand how the large diversity of molecules identified as signals, sensors or effectors could drive a cell to the appropriate plant response and to finally cope with various environmental cues. In this Research Topic we aim to provide an overview of various signaling mechanisms or to present new molecular signals involved in stress response and to demonstrate how basic/fundamental research on cell signaling will help to understand stress responses at the whole plant level
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    Planctomycetes-Verrucomicrobia-Chlamydiae Bacterial Superphylum: New Model Organisms for Evolutionary Cell Biology (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452798
    Language: English
    Pages: 1 Online-Ressource (168 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The Planctomycetes, Verrucomicrobia, Chlamydiae (PVC) and related phyla have recently emerged as fascinating subjects for research in evolutionary cell biology, ecology, biotechnology, evolution and human health. This interest is prompted by particular characteristics observed in the PVC superphylum that are otherwise rarely observed in bacteria but are however still poorly described or understood, such as the presence of a complex endomembrane system, or compacted DNA throughout most of the cell cycle. Therefore, the members of the PVC superphylum represent an excellent example of the value of studying bacteria other than ‘classical’ models
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    The Physiological Functions of the Amyloid Precursor Protein Gene Family (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453559
    Language: English
    Pages: 1 Online-Ressource (275 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer’s disease (AD), as proteolytical cleavage of APP gives rise to the Aß peptide which is deposited in the brains of Alzheimer patients. Despite this, our knowledge of the normal cell biological and physiological functions of APP and the closely related APLPs is limited. This may have hampered our understanding of AD, since evidence has accumulated that not only the production of the Aß peptide but also the loss of APP-mediated functions may contribute to AD pathogenesis. Thus, it appears timely and highly relevant to elucidate the functions of the APP gene family from the molecular level to their role in the intact organism, i.e. in the context of nervous system development, synapse formation and adult synapse function, as well as neural homeostasis and aging. Why is our understanding of the APP functions so limited? APP and the APLPs are multifunctional proteins that undergo complex proteolytical processing. They give rise to an almost bewildering array of different fragments that may each subserve specific functions. While Aß is aggregation prone and neurotoxic, the large secreted ectodomain APPsa - produced in the non-amyloidogenic a-secretase pathway - has been shown to be neurotrophic, neuroprotective and relevant for synaptic plasticity, learning and memory. Recently, novel APP cleavage pathways and enzymes have been discovered that have gained much attention not only with respect to AD but also regarding their role in normal brain physiology. In addition to the various cleavage products, there is also solid evidence that APP family proteins mediate important functions as transmembrane cell surface molecules, most notably in synaptic adhesion and cell surface signaling. Elucidating in more detail the molecular mechanisms underlying these divers functions thus calls for an interdisciplinary approach ranging from the structural level to the analysis in model organisms. Thus, in this research topic of Frontiers we compile reviews and original studies, covering our current knowledge of the physiological functions of this intriguing and medically important protein family
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    Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453177
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders
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    How Can Secretomics Help Unravel the Secrets of Plant-Microbe Interactions? (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450879
    Language: English
    Pages: 1 Online-Ressource (188 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Secretomics describes the ...
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    Ionotropic Glutamate Receptors Trafficking in Health and Disease (2017)
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    ISBN: 9782889450893
    Language: English
    Pages: 1 Online-Ressource (141 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The knowledge about the properties and importance of ionotropic glutamate receptor trafficking is ever increasing. Importantly, the pace of the progress has been accelerated in recent years. Here, our contributors provide a) reviews on specific topics that present an up-to-date overview of the field, as well as b) original articles with the relevant new findings
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    Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450459
    Language: English
    Pages: 1 Online-Ressource (179 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Research on the multiple ...
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    Induction of Central Nervous System Disease by the Adaptive Immune Response (2017)
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    ISBN: 9782889453474
    Language: English
    Pages: 1 Online-Ressource (141 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2017)
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    ISBN: 9782889451197
    Language: English
    Pages: 1 Online-Ressource (92 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance
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    Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452880
    Language: English
    Pages: 1 Online-Ressource (108 p.)
    Series Statement: Frontiers Research Topics
    Abstract: More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases
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    Smelly Fumes: Volatile-Mediated Communication between Bacteria and Other Organisms (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452224
    Language: English
    Pages: 1 Online-Ressource (227 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This e-book summarizes recent advances in the young and rapidly developing field of microbial volatiles. Articles included here reveal novel information about the chemical diversity of bacterial and fungal volatiles, their functions, their roles in inter-specific and inter-kingdom interactions and the metabolic and physiological changes their exposure causes in the target organisms. The e-book is divided in three chapters: (1) Natural Functions of Microbial Volatiles; (2) Volatile Production and Ecosystem Functioning and (3) Volatile Detection and Identification
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    Spores and Spore Formers (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452385
    Language: English
    Pages: 1 Online-Ressource (121 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Bacterial spore formers have been the focus of intense study for almost half a century centered primarily on Bacillus subtilis. This research has given us a detailed picture of the genetic, physiological and biochemical mechanisms that allow bacteria to survive harsh environmental conditions by forming highly robust spores. Although, many basic aspects of this process are now understood in great detail, bacterial sporulation still continues to be a highly attractive model for studying various cell processes at a molecular level. There are several reasons for such scientific interest. First, some of the complex steps in sporulation are not fully understood and/or only are only described by 'controversial' models. Second, intensive research on unicellular development of a single microorganism, B. subtilis, left us largely unaware of the multitude of diverse sporulation mechanisms in many other Gram-positive endospore and exospore formers. This diversity would likely increase if we were to include sporulation processes in the Gram-negative spore formers. In addition, spore formers have great potential in applied research. Spore forming bacteria are becoming increasingly important in the areas of probiotics, vaccine technology and biotechnology. This Research Topic in Frontiers in Microbiology details the most recent advances in basic science of spore research and cover also emerging areas of scientific importance involving the use of spores
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    Recent Advances in the Study of the Host-Fungus Interaction (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450626
    Language: English
    Pages: 1 Online-Ressource (148 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response
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    Recent Advances and Challenges on Big Data Analysis in Neuroimaging (2017)
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    ISBN: 9782889451289
    Language: English
    Pages: 1 Online-Ressource (195 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Big data is revolutionizing our ability to measure and study the human brain. New technology increases the resolution of images that are being study as well as enables researchers to study the brain as it functions. These technological advances are combined with efforts to collect neuroimaging data on large numbers of subjects, in some cases longitudinally. This combination of advances in measurement and scope of studies requires novel development in the statistical analysis. Fast, scalable, robust and accurate models and approaches need to be developed to make headway on these problems. This volume represents a unique collection of researchers providing deep insights on the statistical analysis of big neuroimaging data
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    Rio, Tokyo Paralympic Games and beyond: How to Prepare Athletes with Motor Disabilities for Peaking (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451715
    Language: English
    Pages: 1 Online-Ressource (87 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In 1960, the 9th Annual I ...
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    Evaluation of Building Resilience Under Earthquake Input Using Single, Double and Multiple Impulses (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452705
    Language: English
    Pages: 1 Online-Ressource (61 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This eBook is the third in a series of books on the critical earthquake response of elastic or elastic-plastic structures under near-fault or long-duration ground motions, and includes four original research papers which were published in the specialty section Earthquake Engineering in ‘Frontiers in Built Environment’. Several extensions of the first eBook and the second eBook are included here. The first article is on the earthquake resilience of residential houses after repeated ground motions with high intensity. The 2016 Kumamoto earthquake brought a significant impact on the earthquake resilience of residential houses under repeated ground motions with high intensity in a few days. The necessary strength upgrade withstanding two repeated high-intensity ground motions was found to be 1.5. The second article is concerned with the smart enhancement of earthquake resilience of building structures under both near-fault and long-duration ground motions. A hybrid system of base-isolation and building connection control was proposed and its earthquake resilience to near-fault and long-duration ground motions was evaluated by a double impulse and a multiple impulse. It was demonstrated that the base-isolation is effective for near-fault ground motions and the building connection system using passive dampers is effective for long-duration ground motions. The third article is related to the robustness evaluation of elastic-plastic base-isolated high-rise buildings under resonant near-fault ground motions. The robustness function was introduced to evaluate quantitatively the robustness of elastic-plastic base-isolated high-rise buildings. The fourth article is an extension of the previously proposed energy balance approach to a bilinear elastic-plastic single-degree-of-freedom system under a long-duration sinusoidal ground motion. A historical difficulty in nonlinear vibration posed by Caughey (1960) and Iwan (1961) has been overcome in a smart manner after half a century. The approach presented in this eBook, together with the previous eBooks, is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability and resilience of built environments in the elastic-plastic and nonlinear range
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    Ethylene: A Key Regulatory Molecule in Plants (2017)
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    ISBN: 9782889453412
    Language: English
    Pages: 1 Online-Ressource (310 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Ethylene is a simple gaseous phytohormone with multiple roles in regulation of metabolism at cellular, molecular, and whole plant level. It influences performance of plants under optimal and stressful environments by interacting with other signaling molecules. Understanding the ethylene biosynthesis and action through the plant’s life can contribute to improve the knowledge of plant functionality and use of this plant hormone may drive adaptation and defense of plants from the adverse environmental conditions. The action of ethylene depends on its concentration in cell and the sensitivity of plants to the hormone. In recent years, research on ethylene has been focused, due to its dual action, on the regulation of plant processes at physiological and molecular level. The involvement of ethylene in the regulation of transcription needs to be widely explored involving the interaction with other key molecular regulators. The aim of the current research topic was to explore and update our understanding on its regulatory role in plant developmental mechanisms at cellular or whole plant level under optimal and changing environmental conditions. The present edited volume includes original research papers and review articles describing ethylene’s regulatory role in plant development during plant ontogeny and also explains how it interacts with biotic and abiotic stress factors. This comprehensive collection of researches provide evidence that ethylene is essential in different physiological processes and does not always work alone, but in coordinated manner with other plant hormones. This research topic is also a source of tips for further works that should be addressed for the biology and molecular effects on plants
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    The Role of Play in Child Assessment and Intervention (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452590
    Language: English
    Pages: 1 Online-Ressource (150 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Play is a ubiquitous and universal aspect of early childhood. Although it may take different forms throughout development and across cultures, decades of research have found play to be related to important, positive outcomes. Play provides children with valuable cognitive, emotional, and interpersonal learning opportunities. It can act as a mode of communication for young children and allows them to practice ways of managing complex interpersonal interactions. Specific aspects of play, such as children’s creativity in pretend play, have been associated with resilience and coping. The significance of play in childhood has led to its frequent use in the assessment of child development and in the implementation of child and parent-child psychological and educational interventions. Historically, however, the validity and efficacy of these interventions have not been rigorously evaluated. Further, few assessment and intervention models have included parents, teachers, and other key caregivers, but have focused only on the child. This Research Topic will bring together the most current literature on the use of play in child assessment and intervention
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    Modeling of Visual Cognition, Body Sense, Motor Control and Their Integrations (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451098
    Language: English
    Pages: 1 Online-Ressource (134 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The interdisciplinary studies between neuroscience and information science have greatly promoted the development of these two fields. The achievements of these studies can help humans understand the essence of biological systems, provide computational platforms for biological experiments, and improve the intelligence and performance of the algorithms in information science. This research topic is focused on the computational modeling of visual cognition, body sense, motor control and their integrations. Firstly, the modeling and simulation of vision and body sense are achieved by 1) understanding neural mechanism underlying sensory perception and cognition, and 2) mimicking accordingly the structures and mechanisms of their signal propagation pathways. The achievement of this procedure could provide neural findings for better encoding and decoding visual and somatosensory perception of humans, and help robots or systems build humanoid robust vision, body sensing, and various emotions. Secondly, the modeling and simulation of the motor system of the primate are achieved by mimicking the coordination of bones, muscles and joints and the control mechanisms of the neural system in the brain and spinal cord. This procedure could help robots achieve fast, robust and accurate manipulations and be used for safe human-computer interaction. Finally, by integrating them, more complete and intelligent systems/robots could be built to accomplish various tasks self-adaptively and automatically
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    Methodological Quality of Interventions in Psychology (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452491
    Language: English
    Pages: 1 Online-Ressource (120 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Evaluations of intervention programs seek to present high-quality design, measures and data to assess their merit and worth. While evaluations differ in their purpose, theoretical framework and methodology, their collective aim is to obtain relevant and meaningful information to inform practice, research, and policy. As such, evaluation findings serve to build a body of knowledge on effective approaches to promote designated psychological outcomes, critical to an individual's overall health and well-being. However, as examined in this e-book, methodological weaknesses directly limit the potential of evaluations of intervention programs. As discussed by Chacón-Moscoso and Sanduvete-Chaves, methodological weaknesses can be attributed to how to define and measure methodological quality and the contextual dependency of instruments designed to measure this quality. In response, this e-book provides a collection of studies on methodological approaches to promote the quality of psychological interventions. Specifically, 10 original works published in the Research Topic Methodological Quality of Interventions in Psychology are included. The papers are organized into two chapters. Concretely, Chapter 1 includes studies pertaining to methodological approaches to enhance the quality of psychological intervention, being context independent solutions. Furthermore, Chapter 2 presents original work in different areas (health, education, sport and social welfare) where methodological quality has been better assessed. Collectively, the papers in this e-book serve to expand the awareness of practitioners and researchers interested in psychological interventions of the critical role of methodological quality in this work. This research was funded by the projects 1150096 (Chilean National Fund of Scientific and Technological Development, FONDECYT); and PSI2015-71947-REDT (Spain’s Ministry of Economy and Competitiveness)
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    Modeling Individual Differences in Perceptual Decision Making (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450565
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Series Statement: Frontiers Research Topics
    Abstract: To deal with the abundant ...
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    Flow and Transformations in Porous Media (2017)
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    ISBN: 9782889450770
    Language: English
    Pages: 1 Online-Ressource (200 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Fluid flow in transforming porous rocks, fracture networks, and granular media is a very active interdisciplinary research subject in Physics, Earth Sciences, and Engineering. Examples of natural and engineered processes include hydrocarbon recovery, carbon dioxide geo-sequestration, soil drying and wetting, pollution remediation, soil liquefaction, landslides, dynamics of wet or dry granular media, dynamics of faulting or friction, volcanic eruptions, gas venting in sediments, karst development and speleogenesis, ore deposit development, and radioactive waste disposal. Hydrodynamic flow instabilities and pore scale disorder typically result in complex flow patterning. In transforming media, additional mechanisms come into play: compaction, de-compaction, erosion, segregation, and fracturing lead to changes in permeability over time. Dissolution, precipitation, and chemical reactions between solutes and solids may gradually alter the composition and structure of the solid matrix, either creating or destroying permeable paths for fluid flow. A complex, dynamic feedback thus arises where, on the one hand, the fluid flow affects the characteristics of the porous medium, and on the other hand the changing medium influences the fluid flow. This Research Topic Ebook presents current research illustrating the depth and breadth of ongoing work in the field of flow and transformation in porous media through 15 papers by 72 authors from around the world. The body of work highlights the challenges posed by the vast range of length- and time-scales over which subsurface flow processes occur. Importantly, phenomena from each scale contribute to the larger-scale behavior. The flow of oil and gas in reservoirs, and the flow of groundwater on catchment scale is sensitively linked to pore scale processes and material heterogeneity down to the micrometer scale. The geological features of the same reservoirs and catchments evolved over millions of years, sometimes as a consequence of cracking and fracture growth occurring on the time scale of microseconds. The research presented by the authors of this Research Topic represents a step toward bridging the separation of scales as well as the separation of scientific disciplines so that a more unified picture of flow and transformation in porous media can start to emerge
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    Mind-Brain Plasticity and Rehabilitation of Cognitive Functions: What Techniques Have Been Proven Effective? (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451876
    Language: English
    Pages: 1 Online-Ressource (220 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Rehabilitation of cognitive functions is a primary goal in neurological and psychiatric settings. Cognitive treatments include individual and group exercises, as well as the use of computer programs and virtual reality. Besides, ongoing studies have been examining the clinical usefulness of non-invasive cerebral cortex stimulation in increasing the efficacy of cognitive protocols. Cognitive rehabilitation is based on neuroplasticity and affects brain morphological and physiological responses by integration of behavioral and cognitive changes. The brain correlates of rehabilitation-induced modifications can be investigated through magnetic resonance imaging, both at structural and functional macro-levels. Animal research can integrate such information providing data on axonal regrowth and reshaping of synaptic connectivity in response to treatment. Animal models of neurological and psychiatric conditions have been developed, and preclinical test batteries for the assessment of cognitive functions in animal models of such conditions have been created. The question is then: how does rehabilitation drive reorganization at the neuronal level? The focus of this Research Topic is on rehabilitation-induced cognitive and neural plasticity in adult humans and animal models. The goal is to provide an integrated picture highlighting what techniques have been proven to be effective
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    Molecular Pathogenesis of Pneumococcus (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452781
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Streptococcus pneumoniae has been for decades the number one bacterial killer of children in the world. Although vaccination with pneumococcal vaccines [PCV7, PCV10, and PCV13 (children) or PPSV23 (adults)] has helped decrease the burden of pneumococcal disease (PD), mortality remains high. Therefore, pathogenesis studies are still key toward our understanding of PD and its control. The introduction of pneumococcal vaccines has also created a niche for vaccine-escape clones. Moreover, the rise of multi-drug resistant clones around the world has also posed a serious threat in recent years. The proposed special issue of Frontiers in Cellular and Infection Microbiology highlights many of the recent advances that have been made in pneumococcal pathogenesis, colonization and antibiotic resistance by groups in Latino America, Europe, and the USA
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    The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452538
    Language: English
    Pages: 1 Online-Ressource (161 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function
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    Karolinska Institutet 200-Year Anniversary Symposium on Injuries to the Spinal Cord and Peripheral Nervous System - An Update on Recent Advances in Regenerative Neuroscience (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453245
    Language: English
    Pages: 1 Online-Ressource (74 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The present E-book consists of original articles and reviews published in our Research Topic on injuries to the spinal cord and peripheral nerves and presents a wide array of novel findings and in depth discussions on topics within the field of nerve injury and repair. Our aim with this Research Topic is to bring together knowledge spanning from basic laboratory studies to clinical findings and strategies within the field of spinal cord and nerve injury and repair. We hope this publication will provide a basis for accelerated knowledge exchange within the field and hopefully a subsequent increase in research efforts and collaborations
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    Phage Therapy: Past; Present and Future (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452514
    Language: English
    Pages: 1 Online-Ressource (392 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Historically, the first o ...
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    Plant Competition in a Changing World (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452057
    Language: English
    Pages: 1 Online-Ressource (154 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Competitiveness describes a key ability important for plants to grow and survive abiotic and biotic stresses. Under optimal, but particularly under non-optimal conditions, plants compete for resources including nutrients, light, water, space, pollinators and other. Competition occurs above- and belowground. In resource-poor habitats, competition is generally considered to be more pronounced than in resource-rich habitats. Although competition occurs between different players within an ecosystem such as between plants and soil microorganisms, our topic focusses on plant-plant interactions and includes inter-specific competition between different species of similar and different life forms and intra-specific competition. Strategies for securing resources via spatial or temporal separation and different resource needs generally reduce competition. Increasingly important is the effect of invasive plants and subsequent decline in biodiversity and ecosystem function. Current knowledge and future climate predictions suggest that in some situations competition will be intensified with occurrence of increased abiotic (e.g. water and nutrient limitations) and biotic stresses (e.g. mass outbreak of insects), but competition might also decrease in situations where plant productivity and survival declines (e.g. habitats with degraded soils). Changing interactions, climate change and biological invasions place new challenges on ecosystems. Understanding processes and mechanisms that underlie the interactions between plants and environmental factors will aid predictions and intervention. There is much need to develop strategies to secure ecosystem services via primary productivity and to prevent the continued loss of biodiversity. This Research Topic provides an up-to-date account of knowledge on plant-plant interactions with a focus on identifying the mechanisms underpinning competitive ability. The Research Topic aims to showcase knowledge that links ecological relevance with physiological processes to better understanding plant and ecosystem function
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    Plants; Stress & Proteins (2017)
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    ISBN: 9782889452675
    Language: English
    Pages: 1 Online-Ressource (323 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Biotic and abiotic stress factors deliver a huge impact on plant life. Biotic stress factors such as damage through pathogens or herbivore attack, as well as abiotic stress factors like variation in temperature, rainfall and salinity, have placed the plant kingdom under constant challenges for survival. As a consequence, global agricultural and horticultural productivity has been disturbed to a large extent. Being sessile in nature, plants cannot escape from the stress, and instead adapt changes within their system to overcome the adverse conditions. These changes include physiological, developmental and biochemical alterations within the plant body which influences the genome, proteome and metabolome profiles of the plant. Since proteins are the ultimate players of cellular behavior, proteome level alterations during and recovery period of stress provide direct implications of plant responses towards stress factors. With current advancement of modern high-throughput technologies, much research has been carried out in this field. This e-book highlights the research and review articles that cover proteome level changes during the course or recovery period of various stress factors in plant life. Overall, the chapters in this e-book has provided a wealth of information on how plants deal with stress from a proteomics perspective
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    Organogenesis From Development to Disease (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453184
    Language: English
    Pages: 1 Online-Ressource (110 p.)
    Series Statement: Frontiers Research Topics
    Abstract: During embryonic development there are many processes that must take place to produce a viable and healthy fetus. Alterations in the cellular and/or molecular interactions within any particular organ can cause catastrophic defects leading to defective organogenesis and death of the embryo. Even slight malformations of the organs can cause developmental reprogramming and increase the likelihood of adult onset diseases. The use of experimental animals with genetic mutations that mimic many human conditions has lead to significant scientific advancement of these complex and multifaceted diseases. Furthermore, the utilization of organ culture systems has made for profound insights into the formation of organs. Over recent years, the technology related to molecular profiling and imaging of developing organs has dramatically improved, leading to the identification of subtle genetic and phenotypic alterations. This research topic will focus on the area of organ formation and modeling of human developmental diseases
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    Optimizing the Delivery of Multiple Ecosystem Goods and Services in Agricultural Systems (2017)
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    ISBN: 9782889452965
    Language: English
    Pages: 1 Online-Ressource (199 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Agricultural land is subjected to a variety of societal pressures, as demands for food, animal feed, and biomass production increase, with an added requirement to simultaneously maintain natural areas and mitigate climatic and environmental impacts. The biotic elements of agricultural systems interact with the abiotic environment to generate a number of ecosystem functions that offer services benefiting humans across many scales of time and space. The intensification of agriculture generally reduces biodiversity including that within soil, and impacts negatively upon a number of regulating and supporting ecosystem services. There is a global need toward achieving sustainable agricultural systems, as also highlighted in the United Nations Sustainable Development Goals. There is hence a need for management regimes that enhance both agricultural production and the associated provision of multiple ecosystem services. The articles of this Research Topic enhance our knowledge of how management practices applied to agricultural systems affect the delivery of multiple ecosystem services and how trade-offs between provisioning, regulating, and supporting services can be handled both above- and below-ground. They also show the diversity of topics that need to be considered within the framework of ecosystem services delivered by agricultural systems, from knowledge on basic concepts and newly-proposed frameworks, to a focus on specific ecosystem types such as grasslands and high nature-value farmlands, pollinator habitats, and soil habitats. This diversity of topics indicates the need for broader-scope research, integrated with targeted scientific research to promote sustainable agricultural practices and to ensure food security
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    Online and Offline Modulators of Motor Learning (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451661
    Language: English
    Pages: 1 Online-Ressource (155 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Both the acquisition of new and the modification of previously acquired motor skills are necessary to achieve optimal levels of motor performance in everyday functioning as well as to attain expert performance levels that are evident in sports and arts. A multitude of factors have been shown to influence the various stages of the learning process, from the acquisition (i.e., motor memory encoding) to the consolidation and subsequent retention of a skill. These factors, or modulators, can affect learning through online processes taking place during practice of a new motor skill or through offline processes occurring in the absence of task performance (i.e., after training sessions). Although much of the recent research from various disciplines has placed an increased emphasis on identifying factors that can influence the motor learning process, we lack an integrated understanding of online and offline determinants of motor skill behaviours. Potential motor learning modulators include, but are certainly not limited to, stress, anxiety, attention, executive functioning, social interaction, stimulus-response mapping, training schedule/regimen, learning environment, vigilance/consciousness states including sleep, wakefulness or meditation, brain stimulation, interference as well as resting state brain connectivity. Pathological and non-pathological (i.e., development or aging) changes in the brain can also be conceptualized as potential modulators. The aim of this Research Topic is to bridge research from the cognitive, sensory, motor and psychological domains using various behavioural paradigms and neuroimaging techniques in order to provide a comprehensive view of the online and offline modulators of motor learning, and how they interact to influence motor performance. Critically, the overarching goal is to gain a better understanding of how motor behaviour can be optimized. We believe that merging research from diverse neuroscientific communities would contribute to fulfilling this goal and potentially highlight possible shared neurophysiological mechanisms influencing motor learning
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    How Do Emotions and Feelings Regulate Physical Activity? (2017)
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    ISBN: 9782889452712
    Language: English
    Pages: 1 Online-Ressource (149 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Up to date the scientific ...
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    Hybrid Solutions for the Modelling of Complex Environmental Systems (2017)
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    ISBN: 9782889450558
    Language: English
    Pages: 1 Online-Ressource (184 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Systems studied in environmental science, due to their structure and the heterogeneity of the entities composing them, often exhibit complex dynamics that can only be captured by hybrid modeling approaches. While several concurrent definitions of “hybrid modeling” can be found in the literature, it is defined here broadly as the approach consisting in coupling existing modelling paradigms to achieve a more accurate or efficient representation of systems. The need for hybrid models generally arises from the necessity to overcome the limitation of a single modeling technique in terms of structural flexibility, capabilities, or computational efficiency. This book brings together experts in the field of hybrid modelling to demonstrate how this approach can address the challenge of representing the complexity of natural systems. Chapters cover applied examples as well as modeling methodology.Systems studied in environmental science, due to their structure and the heterogeneity of the entities composing them, often exhibit complex dynamics that can only be captured by hybrid modeling approaches. While several concurrent definitions of “hybrid modeling” can be found in the literature, it is defined here broadly as the approach consisting in coupling existing modelling paradigms to achieve a more accurate or efficient representation of systems. The need for hybrid models generally arises from the necessity to overcome the limitation of a single modeling technique in terms of structural flexibility, capabilities, or computational efficiency. This book brings together experts in the field of hybrid modelling to demonstrate how this approach can address the challenge of representing the complexity of natural systems. Chapters cover applied examples as well as modeling methodology
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    International Plant Proteomics Organization (INPPO) World Congress 2014 (2017)
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    ISBN: 9782889450602
    Language: English
    Pages: 1 Online-Ressource (407 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The field of proteomics h ...
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    Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes (2017)
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    ISBN: 9782889450824
    Language: English
    Pages: 1 Online-Ressource (88 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation
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    Integrative Research on Organic Matter Cycling Across Aquatic Gradients (2017)
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    ISBN: 9782889452125
    Language: English
    Pages: 1 Online-Ressource (201 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural world functions, it is increasingly important that we recognize the interconnected nature of earth systems and embrace the complexities of ecosystem transitions. We are pleased to present this body of work, which embodies the spirit of research spanning across the terrestrial-aquatic continuum, from mountains to the sea. Sincerely, The Editors
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    Interoception, Contemplative Practice, and Health (2017)
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    ISBN: 9782889450947
    Language: English
    Pages: 1 Online-Ressource (316 p.)
    Series Statement: Frontiers Research Topics
    Abstract: There is an emergent movement of scientists and scholars working on somatic awareness, interoception and embodiment. This work cuts across studies of neurophysiology, somatic anthropology, contemplative practice, and mind-body medicine. Key questions include: How is body awareness cultivated? What role does interoception play for emotion and cognition in healthy adults and children as well as in different psychopathologies? What are the neurophysiological effects of this cultivation in practices such as Yoga, mindfulness meditation, Tai Chi and other embodied contemplative practices? What categories from other traditions might be useful as we explore embodiment? Does the cultivation of body awareness within contemplative practice offer a tool for coping with suffering from conditions, such as pain, addiction, and dysregulated emotion? This emergent field of research into somatic awareness and associated interoceptive processes, however, faces many obstacles. The principle obstacle lies in our 400-year Cartesian tradition that views sensory perception as epiphenomenal to cognition. The segregation of perception and cognition has enabled a broad program of cognitive science research, but may have also prevented researchers from developing paradigms for understanding how interoceptive awareness of sensations from inside the body influences cognition. The cognitive representation of interoceptive signals may play an active role in facilitating therapeutic transformation, e.g. by altering context in which cognitive appraisals of well-being occur. This topic has ramifications into disparate research fields: What is the role of interoceptive awareness in conscious presence? How do we distinguish between adaptive and maladaptive somatic awareness? How do we best measure somatic awareness? What are the consequences of dysregulated somatic/interoceptive awareness on cognition, emotion, and behavior? The complexity of these questions calls for the creative integration of perspectives and findings from related but often disparate research areas including clinical research, neuroscience, cognitive psychology, anthropology, religious/contemplative studies and philosophy
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    Industrial and Host Associated Stress Responses in Food Microbes. Implications for Food Technology and Food Safety (2017)
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    ISBN: 9782889452934
    Language: English
    Pages: 1 Online-Ressource (295 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Throughout the food processing chain and after ingestion by the host, food associated bacteria have to cope with a range of stress factors such as thermal and/or non-thermal inactivation treatments, refrigeration temperatures, freeze-drying, high osmolarity, acid pH in the stomach or presence of bile salts in the intestine, that threaten bacterial survival. The accompanying plethora of microbial response and adaptation phenomena elicited by these stresses has important implications for food technology and safety. Indeed, while resistance development of pathogenic and spoilage microorganisms may impose health risks for the consumer and impart great economic losses to food industries, reduced survival of probiotic bacteria may strongly compromise their claimed health benefit attributes. As a result, substantial research efforts have been devoted in the last decades to unravel the mechanisms underlying stress response and resistance development in food associated microorganisms in order to better predict and improve (i) the inactivation of foodborne pathogens and spoilage microorganisms on the one hand and (ii) the robustness and performance of beneficial microorganisms on the other. Moreover, the recent implementation of system-wide omics and (single-)cell biology approaches is greatly boosting our insights into the modes of action underlying microbial inactivation and survival. This Research Topic aims to provide an avenue for dissemination of recent advances within the field of microbial stress response and adaptation, with a particular focus not only on food spoilage and pathogenic microorganisms but also on beneficial microbes in foods
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    Neural and Computational Modeling of Movement Control (2017)
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    ISBN: 9782889451302
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the study of sensorimo ...
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    The Impact of Sensory; Linguistic and Social Deprivation on Cognition (2017)
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    ISBN: 9782889453542
    Language: English
    Pages: 1 Online-Ressource (183 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Early experience plays a crucial role in determining the trajectory of cognitive development. For example, early sensory deprivation is known to induce neural reorganization by way of adaptation to the altered sensory experience. Neville and Bavelier’s “compensatory theory’’ hypothesizes that loss of one sense may bring about a sensory enhancement in the remaining modalities. Sensory deprivation will, however, also impact the age of emergence, or the speed of acquisition of cognitive abilities that depend upon sensory inputs. Understanding how a child’s early environment shapes their cognition is not only of theoretical interest. It is essential for the development of early intervention programs that address not just the early deprivation itself, but also the cognitive sequelae of such deprivation. The articles in this e-book all address different aspects of deprivation - sensory, linguistic, and social - and explore the impacts of such deprivation on a wide range of cognitive outcomes. In reading these contributions, it is important to note that sensory, linguistic, and social deprivation are not independent factors in human experience. For example, a child born deaf into a hearing family is likely to experience delays in exposure to natural language, with subsequent limits on their linguistic competence having an effect on social interactions and inclusion: a child raised in environments where social interaction is highly limited is also likely to experience reductions in the quantity and quality of linguistic inputs. Future work will need to carefully examine the complex interactions between the sensory, linguistic and social environments of children raised in atypical or impoverished environments
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    The HSP70 Molecular Chaperone Machines (2017)
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    ISBN: 9782889451258
    Language: English
    Pages: 1 Online-Ressource (69 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each presenting a complementary aspect of HSP70’s structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism
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    Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451036
    Language: English
    Pages: 1 Online-Ressource (104 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions
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    Grassland-Invertebrate Interactions: Plant Productivity; Resilience and Community Dynamics (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452903
    Language: English
    Pages: 1 Online-Ressource (254 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Natural and anthropogenic grasslands such as prairies, meadows, rangelands, and pastures cover more than 40% of the planet’s surface and provide a wealth of ecological services. Grasslands alone store one third of the global carbon stocks and grass roots, through their specific architectures, ensure water cycling and prevent the erosion of fertile topsoil. In addition, grasslands are of vital importance for human food production as vast areas of rangelands and pastures provide feed for livestock. Pastoral legumes mobilize atmospheric nitrogen and improve fertility of arable soils. Not least, grasslands are an essential genetic resource. The three major crop species that feed half of the global population have been bred from wild grasses. Ancestors of our contemporary turf cultivars, common components of urban landscapes and recreation spaces, originated from wild grasslands. Although natural and managed grasslands represent pivotal ecosystems, many aspects of how they function are poorly understood. To date, most attention has focused on grassland primary producers (i.e. forage plants) and mammalian grazers but invertebrates are likely to play an equally, if not more important role in grassland ecosystem functioning. In Australian pastures, for example, the biomass of root-feeding scarab beetles can often exceed that of sheep and plant damage caused by invertebrates is sometimes equivalent to an average dairy cow’s grass consumption. Indeed, grasslands are one of the most densely populated ecosystems with invertebrates being probably the most important engineers that shape both plant communities and the grassland as a whole. In a rapidly changing world with increasing anthropogenic pressure on grasslands, this Research Topic focuses on: 1. How grassland habitats shape invertebrate biodiversity 2. Impacts of climate change on grassland-invertebrate interactions 3. Plant and invertebrate pest monitoring and management 4. Plant-mediated multitrophic interactions and biological control in grasslands 5. Land use and grassland invertebrates 6. Plant resistance to invertebrate pests Given the increasing demand for food and land for human habitation, unprecedented threats to grasslands are anticipated. Resilient to some extent, these key ecosystems need to be better comprehended to guarantee their sustainable management and ecosystem services
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    Non-conventional Yeast in the Wine Industry (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450534
    Language: English
    Pages: 1 Online-Ressource (177 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Saccharomyces cerevisiae strains that exhibit high ethanol tolerance and excellent fermentative ability are extensively used in winemaking as selected starters. However, a side-effect of the widespread use of these commercial starter cultures is the elimination of native microbiota, which might result in wines with similar analytical and sensory properties, depriving them from the variability, complexity and personality that define the typicality of a wine. Nonetheless, a way of balancing control and yeast population diversity during wine fermentation is the selection of non-Saccharomyces yeasts with optimal oenological traits. Therefore, a current trend in enology is the implementation of mixed- or multi-starters cultures, combining S. cerevisiae that remains the yeast species required for the completion of fermentation and non-Saccharomyces yeasts isolated from the native flora of grape juices. This research topic mainly deals with possible applications of different non-Saccharomyces yeast to wine production such as aroma production, ethanol reduction or biocontrol.Saccharomyces cerevisiae strains that exhibit high ethanol tolerance and excellent fermentative ability are extensively used in winemaking as selected starters. However, a side-effect of the widespread use of these commercial starter cultures is the elimination of native microbiota, which might result in wines with similar analytical and sensory properties, depriving them from the variability, complexity and personality that define the typicality of a wine. Nonetheless, a way of balancing control and yeast population diversity during wine fermentation is the selection of non-Saccharomyces yeasts with optimal oenological traits. Therefore, a current trend in enology is the implementation of mixed- or multi-starters cultures, combining S. cerevisiae that remains the yeast species required for the completion of fermentation and non-Saccharomyces yeasts isolated from the native flora of grape juices. This research topic mainly deals with possible applications of different non-Saccharomyces yeast to wine production such as aroma production, ethanol reduction or biocontrol
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    Nature and Environment: The Psychology of Its Benefits and Its Protection (2017)
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    ISBN: 9782889198504
    Language: English
    Pages: 1 Online-Ressource (136 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Our Research Topic section entitled: "Nature and the environment: The psychology of its benefits and its protection" will have two main lines. The first line of articles will center upon cutting-edge research showing how interacting with nature, can affect health, well-being, and overall improve cognition and affect. Articles in this line will stress in what ways nature can improve psychological functioning and health and also discuss the theories and evidence as to why nature can improve psychological functioning. For this line, we welcome submission of articles that discuss the psychological, health and well-being benefits from interacting with nature as well as submissions that focus on theoretical considerations and underlying mechanisms that lead to the restorative effects of interacting with nature. Given that nature can have a positive impact on psychological functioning and overall health, it is also important to understand the variables that facilitate people’s recognition of environmental issues that can help foster a more positive attitude towards the preservation of nature. This brings us to the second line of articles which will center upon the psychological mechanisms that make individuals more or less likely to accept the seriousness of environmental challenges such as climate change. Given the new cutting-edge research in this field we may be able to make individuals more proactive in the protection of the environment and more accepting of policy measures required to mitigate climate change. We see this research topic as a way for psychological scientists to contribute substantially to an important area of public debate and policy. For this line we welcome articles that will focus on ways in which people respond to various framings of policy relevant information and how morality may play into the individuals policy views that center on climate change and environmental protection
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    Fitness Costs and Benefits of Female Song (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452583
    Language: English
    Pages: 1 Online-Ressource (186 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Bird song, traditionally regarded as primarily a male trait, is in fact widespread among female songbirds and was probably present in the ancestor of modern songbirds (Odom et al 2014 Nature Communications). These recent findings challenge the view that sexual dimorphism in the expression and complexity of song is largely the outcome of sexual selection on males. It is now clear that understanding the evolution of bird song requires explaining variation within and among species in the expression and complexity of female song. To do this, we need a better understanding of the nature of variation in female song in different contexts and systems, as well as the fitness costs and benefits of variation in the expression and complexity of female song. This Research Topic draws together current research on female song with the goal of understanding the fitness costs and benefits of the diversity of female singing behaviour apparent among songbirds. It includes articles ranging from single-species studies investigating how female song varies with context and contrasts with male song, to comparative analyses exploring relationships between female song and ecological, social, and other factors, as well as opinion pieces
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    Genomic Approaches for Improvement of Understudied Grasses (2017)
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    ISBN: 9782889452422
    Language: English
    Pages: 1 Online-Ressource (165 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Grasses are diverse, spanning native prairies to high-yielding grain cropping systems. They are valued for their beauty and useful for soil stabilization, pollution mitigation, biofuel production, nutritional value, and forage quality; grasses encompass the most important grain crops in the world. There are thousands of distinct grass species and many have promiscuous hybridization patterns, blurring species boundaries. Resources for advancing the science and knowledgebase of individual grass species or their unique characteristics varies, often proportional to their perceived value to society. For many grasses, limited genetic information hinders research progress. Presented in this research topic is a brief snapshot of creative efforts to apply modern genomics research methodologies to the study of several minor grass species
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    Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches (2017)
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    ISBN: 9782889451722
    Language: English
    Pages: 1 Online-Ressource (153 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Mounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children’s brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children’s brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors
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    Autism Spectrum Disorders (ASD) - Searching for the Biological Basis for Behavioral Symptoms and New Therapeutic Targets (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451128
    Language: English
    Pages: 1 Online-Ressource (178 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Autism Spectrum Disorder (ASD) is currently diagnosed based on a series of behavioral tests. The challenge for researchers is to try to uncover the biological basis for these typical behaviors in order to improve diagnosis and identify potential targets for treatment. A multidisciplinary approach is necessary in order to move forward. This includes analysis of the current animal models for ASD and their suitability, reviewing immunological, immunogenetic and epigenetic research, reassessing clinical diagnostic tools, and surveying radiological, pathological, and serological records for clues. This volume includes research from some of the leading researchers on ASD. We are hopeful that it will stimulate further dialogue and research in this challenging field
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    Biological Engagement Programs: Reducing Threats and Strengthening Global Health Security Through Scientific Collaboration (2017)
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    ISBN: 9782889452736
    Language: English
    Pages: 1 Online-Ressource (199 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Biological engagement programs are a set of projects or activities between partner countries that strengthen global health security to achieve mutually beneficial outcomes. Engagement programs are an effective way to work collaboratively towards a common threat reduction goal, usually with a strong focus on strengthening health systems and making the world a safer place. Cooperative programs are built upon trust and sharing of information and resources to increase the capacity and capabilities of partner countries. Biological engagement programs reduce the threat of infectious disease with a focus on pathogens of security concern, such as those pathogens identified by the U.S. Government as Biological Select Agent and Toxins. These programs seek to develop technical or scientific relationships between countries to combat infectious diseases both in humans and animals. Through laboratory biorisk management, diagnostics, pathogen detection, biosurveillance and countermeasure development for infectious diseases, deep relationships are fostered between countries. Biological engagement programs are designed to address dual-use issues in pathogen research by promoting responsible science methodologies and cultures. Scientific collaboration is a core mechanism for engagement programs are designed to strengthen global health security, including prevention of avoidable epidemics; detection of threats as early as possible; and rapid and effective outbreak response. This Research Topic discusses Biological Engagement Programs, highlighting the successes and challenges of these cooperative programs. Articles in this topic outlined established engagement programs as well as described what has been learned from historical cooperative engagement programs not focused on infectious diseases. Articles in this topic highlighted selected research, trainings, and programs in Biological Engagement Programs from around the world. This Topic eBook first delves into Policies and Lessons Learned; then describes Initiatives in Biosafety & Biosecurity; the core of this work documents Cooperative Research Results from the field; then lastly the Topic lays out potential Future Directions to the continued success of the World’s cooperative science in reducing the threat of infectious diseases
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    Executive Functions in Psychiatric Disorders (2017)
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    ISBN: 9782889453061
    Language: English
    Pages: 1 Online-Ressource (142 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Executive Functions comprise a range of neuropsychological processes related to intentional behavior and cognitive control. There are several theoretical models defining and explaining the concept of Executive Functions. Most of these models consider that the term Executive Functions encompasses cognitive process as working memory, cognitive flexibility, inhibitory control and other complex functions as planning, problem-solving and abstract reasoning. Other models argue that motivational and emotional functions, such as affective decision-making, reside under the concept of Executive Function. Much evidence supports how complex cognitive functions are related to the physiological activity of brain networks, including the frontal cortex and its connections with subcortical structures. Several psychiatric disorders related to impairment in these brain networks (eg., bipolar disorder, schizophrenia, ADHD, obsessive-compulsive disorder, and drug addiction) leading to deficits in Executive Functions. These cognitive deficits affect patients’ everyday functioning, worsening the clinical course of the disease. For example, deficits in Executive Functions are related to suicide behavior in bipolar disorder patients. Furthermore, these deficits also relate to obesity, a lack of adherence to treatment and an underperformance in the workplace and educational settings. The understanding of the role of deficits in Executive Functions, including its neurobiological basis, developmental trajectories, and relationship with clinical outcomes, is fundamental to improve clinical management of psychiatric patients. This research topic includes 13 articles with interdisciplinary contributions related to the understanding of the deficits in Executive Functions and its relationship with clinical manifestations in psychiatric disorders
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    Circadian Rhythms and Metabolism (2017)
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    ISBN: 9782889452828
    Language: English
    Pages: 1 Online-Ressource (188 p.)
    Series Statement: Frontiers Research Topics
    Abstract: One of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health
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    Danger Signals Triggering Immune Response and Inflammation (2017)
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    ISBN: 9782889452842
    Language: English
    Pages: 1 Online-Ressource (205 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The immune system detects ...
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    Continuous Quality Improvement - Advancing Understanding of Design, Application, Impact and Evaluation of CQI Approaches (2017)
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    ISBN: 9782889453771
    Language: English
    Pages: 1 Online-Ressource (100 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Continuous Quality Improvement (CQI) methods are increasingly widely used to bridge the gaps between the evidence base for best clinical practice, what actually happens in practice, and the achievement of better population health outcomes. Among a range of quality improvement strategies, CQI methods are characterised by iterative and ongoing use of specific processes to identify quality problems, develop solutions, and implement and evaluate changes. The application of CQI processes in health is evolving and evidence of their success continues to emerge. There is, however, a need to enhance understanding of how best to implement, scale-up and evaluate CQI programs for the purpose of improving quality of care and population health outcomes in different contexts. This research topic aims to attract articles that add to knowledge of useful approaches to tailoring CQI methods for different contexts or purposes, and for implementation, scale-up and evaluation of CQI interventions/programs
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    Cancer Care Delivery and Women's Health (2017)
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    ISBN: 9782889453092
    Language: English
    Pages: 1 Online-Ressource (153 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because women’s health care has its own unique challenges, the intersection between cancer care delivery and women’s health is to be examined in this Frontiers in Oncology issue. The unique opportunities and challenges of improving the health care system for women with breast and gynecologic cancers are to be explored in depth. We will visit many topics of cancer care delivery with the unique perspective geared towards the care of women’s malignancies
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    The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation (2017)
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    ISBN: 9782889452231
    Language: English
    Pages: 1 Online-Ressource (100 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration
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    Antimicrobial Resistance and Virulence Common Mechanisms (2017)
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    ISBN: 9782889451814
    Language: English
    Pages: 1 Online-Ressource (138 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences
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    Bridging the Theories of Affordances and Limb Apraxia (2017)
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    ISBN: 9782889452255
    Language: English
    Pages: 1 Online-Ressource (160 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Affordances are meaningful relations between the features of observed objects and the observer's action systems with its proper abilities. The notion of affordance integrates perceptual, cognitive and motor functions, so that perceiving an object, conducting cognitive operations on it, and executing motor actions with it cannot be considered as independent functions. Limb apraxia is a higher-order motor disorder that refers to disturbance of one or more of three domains: imitation of meaningless gestures, pantomime of meaningful gestures, and disturbance of interaction with objects. The first aim of the Research Topic was to put together theoretical and research contributions on affordance mechanisms to highlight their role in explaining apraxia deficits. The second aim was to clarify how studies on apraxia have implications for theories of affordances
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    Alternatives to Antimicrobial Growth Promoters and Their Impact in Gut Microbiota, Health and Disease (2017)
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    ISBN: 9782889453757
    Language: English
    Pages: 1 Online-Ressource (92 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In the context of disease pathogenesis, it has been observed that after inadequate administration of antibiotics, animals become more susceptible to intestinal colonization and organ invasion by enteropathogens, these could be related to changes caused in the gastrointestinal microbial community. Therefore, we must reconsider the negative consequences that disruption of the microbiome has in the biology of metazoans (dysbacteriosis). Alternations of the intestinal microbiota composition in animals can be caused by multiple factors, including the misuse of antibiotics, having as a result a negative impact on the development and function of the immune, endocrine, nervous, and digestive systems. For this reason, social concerns regarding the development of antibiotic-resistant microorganisms have resulted in an urgent necessity to find feasible alternatives to maintain animal health and performance without the use of antibiotic growth promoters (AGP), in order to sustain livestock production as an economically viable source of food for human consumption. Hence, research about AGP alternatives such as probiotics, prebiotics, phytochemicals, organic acids, enzymes, and vaccines has become a priority for many scientists around the world
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    Advances in Emotion Regulation: From Neuroscience to Psychotherapy (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452439
    Language: English
    Pages: 1 Online-Ressource (159 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Emotions are the gift nature gave us to help us connect with others. Emotions do not come from out of nowhere. Rather, they are constantly generated, usually by stimuli in our interpersonal world. They bond us to others, guide us in navigating our social interactions, and help us care for each other. Paraphrasing Shakespeare, “Our relationships are such stuff as emotions are made of”. Emotions express our needs and desires. When problems happen in our relationships, emotions arise to help us fixing those problems. However, when emotions can become dysregulated, pathology begins. Almost all forms of psychopathology are associated with dysregulated emotions or dysregulatory mechanisms. These dysregulated emotions can become regulated when the therapist helps clients express, face and regulate their emotions, and channel them into healthy actions. This research topic gathers contributions from affective neuroscientists and psychotherapists to illustrate how our emotions become dysregulated in life and can become regulated through psychotherapy
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  • 89
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    Application of Antigen Cross-Presentation Research into Patient Care (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451913
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view
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  • 90
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    Anatomy and Plasticity in Large-Scale Brain Models (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889450657
    Language: English
    Pages: 1 Online-Ressource (173 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Supercomputing facilities ...
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  • 91
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    Advances and Trends in Development of Plant Factories (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451395
    Language: English
    Pages: 1 Online-Ressource (203 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The plant factory is a facility that aids the steady production of high-quality vegetables all year round by artificially controlling the cultivation environment (e.g., light, temperature, humidity, carbon dioxide concentration, and culture solution), allowing growers to plan production. By controlling theinternal environment,plant factories can produce vegetables about two to four times faster than by typical outdoor cultivation. In addition, as multiple cultivation shelves (a multi-shelf system) are used, the mass production of vegetables in a small space is facilitated. This research topic presents some new trends on intelligent measuring systems; environment controlled and optimization; favonoids; phenylpropanoids, transcriptomes, and bacteria
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  • 92
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    Neuropeptides and Behaviour: From Motivation to Psychopathology (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453078
    Language: English
    Pages: 1 Online-Ressource (146 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The discovery of the involvement of neuropeptides with behaviours other than regulatory motivated ones took place in the midst of 1960’s with David de Wied’s first report on the influence of pituitary peptides on memory. This major scientific breakthrough opened a new frontier of studies in Endocrinology and its related fields, Neuroendocrinology and Psychoneuroendocrinology. Neuropeptides were initially thought to be involved in homeostatic regulation and secreted only from neurons located in the hypothalamus; they are now recognized neurotransmitters, produced in and secreted from distinct brain areas, associated with a myriad of, not only, motivated, but also psychopathological behaviours. Motivated behaviours are determinant for individual and species survival, but their expression in a large spectrum and deviations from average may give rise to a number of psychiatric conditions
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  • 93
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    Neural Mechanisms of Perceptual Categorization as Precursors to Speech Perception (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451586
    Language: English
    Pages: 1 Online-Ressource (186 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Perceptual categorization is fundamental to the brain’s remarkable ability to process large amounts of sensory information and efficiently recognize objects including speech. Perceptual categorization is the neural bridge between lower-level sensory and higher-level language processing. A long line of research on the physical properties of the speech signal as determined by the anatomy and physiology of the speech production apparatus has led to descriptions of the acoustic information that is used in speech recognition (e.g., stop consonants place and manner of articulation, voice onset time, aspiration). Recent research has also considered what visual cues are relevant to visual speech recognition (i.e., the visual counter-parts used in lipreading or audiovisual speech perception). Much of the theoretical work on speech perception was done in the twentieth century without the benefit of neuroimaging technologies and models of neural representation. Recent progress in understanding the functional organization of sensory and association cortices based on advances in neuroimaging presents the possibility of achieving a comprehensive and far reaching account of perception in the service of language. At the level of cell assemblies, research in animals and humans suggests that neurons in the temporal cortex are important for encoding biological categories. On the cellular level, different classes of neurons (interneurons and pyramidal neurons) have been suggested to play differential roles in the neural computations underlying auditory and visual categorization. The moment is ripe for a research topic focused on neural mechanisms mediating the emergence of speech representations (including auditory, visual and even somatosensory based forms). Important progress can be achieved by juxtaposing within the same research topic the knowledge that currently exists, the identified lacunae, and the theories that can support future investigations. This research topic provides a snapshot and platform for discussion of current understanding of neural mechanisms underlying the formation of perceptual categories and their relationship to language from a multidisciplinary and multisensory perspective. It includes contributions (reviews, original research, methodological developments) pertaining to the neural substrates, dynamics, and mechanisms underlying perceptual categorization and their interaction with neural processes governing speech perception
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  • 94
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    Mycoplasma pneumoniae Clinical Manifestations, Microbiology, and Immunology (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453627
    Language: English
    Pages: 1 Online-Ressource (175 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Mycoplasma pneumoniae (Mp) is a major human pathogen that causes both upper and lower respiratory infections, and is one of the leading causes of community acquired pneumonia (CAP), accounting for 11–15% of CAP throughout the world. Additionally it is known to induce an inflammatory process which depends on several mechanisms such as virulence of Mp (lipoproteins, community acquired respiratory distress syndrome (CARDS) toxin, oxidative products) and host defenses (cellular immunity and humoral immunity). Although it is a common pathogen, the pathogenesis for Mp infections is not yet fully understood. From the clinical point of view, since the pioneer studies in the 1960s and 1970s on the clinical presentation of Mp associated disease, the diagnostics approaches have changed dramatically leading to a better understanding of the clinical presentation and new issues have emerged - such as antibiotics resistance. The purpose of this Frontiers ebook is to thoroughly review and discuss the clinical presentation in view of the improved diagnostics, microbiological and immunological analysis of Mp infections, with focus on the history of Mp, clinical features of disease, bacterial structure of Mp and mechanism of gliding, clinical and laboratory diagnostics, the role of lipoproteins and Toll-like receptor, CARDS toxin, subtyping of Mp isolates and genome analysis, macrolide resistance and treatment
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  • 95
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    Signal Transduction in Stomatal Guard Cells (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451678
    Language: English
    Pages: 1 Online-Ressource (105 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Stomata, the tiny pores on leaf surface, are the gateways for CO2 uptake during photosynthesis as well as water loss in transpiration. Further, plants use stomatal closure as a defensive response, often triggered by elicitors, to prevent the entry of pathogens. The guard cells are popular model systems to study the signalling mechanism in plant cells. The messengers that mediate closure upon perception of elicitors or microbe associated molecular patterns (MAMPs) are quite similar to those during ABA effects. These components include reactive oxygen species (ROS), nitric oxide (NO), cytosolic pH and intracellular Ca2+. The main components are ROS, NO and cytosolic free Ca2+. The list extends to others, such as G-proteins, protein phosphatases, protein kinases, phospholipids and ion channels. The sequence of these signalling components and their interaction during stomatal signalling are complex and quite interesting. The present e-Book provides a set of authoritative articles from ‘Special Research Topic’ on selected areas of stomatal guard cells. In the first set of two articles, an overview of ABA and MAMPs as signals is presented. The next set of 4 articles, emphasize the role of ROS, NO, Ca2+ as well as pH, as secondary messengers. The next group of 3 articles highlight the recent advances on post-translational modification of guard cell proteins, with emphasis on 14-3-3 proteins and MAPK cascades. The last article described the method to isolate epidermis of grass species and monitor stomatal responses to different signals. Our e-Book is a valuable and excellent source of information for all those interested in guard cell function as well as signal transduction in plant cells
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  • 96
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    Signalling Pathways in Embryonic Development (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453467
    Language: English
    Pages: 1 Online-Ressource (177 p.)
    Series Statement: Frontiers Research Topics
    Abstract: The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches
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  • 97
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    Recent Advances in Geomicrobiology of the Ocean Crust (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889452835
    Language: English
    Pages: 1 Online-Ressource (328 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Igneous oceanic crust is one of the largest potential habitats for life on earth, and microbial activity supported by rock-water-microbe reactions in this environment can impact global biogeochemical cycles. However, our understanding of the microbiology of this system, especially the subsurface “deep biosphere” component of it, has traditionally been limited by sample availability and quality. Over the past decade, several major international programs (such as the Center for Dark Energy Biosphere Investigations, the current International Ocean Discovery Program and its predecessor Integrated Ocean Drilling Program, and the Deep Carbon Observatory) have focused on advancing our understanding of life in this cryptic, yet globally relevant, biosphere. Additionally, many field and laboratory research programs are examining hydrothermal vent systems –a seafloor expression of seawater that has been thermally and chemically altered in subseafloor crust – and the microbial communities supported by these mineral-rich fluids. The Frontiers in Microbiology 3 September 2017 | Recent Advances in Geomicrobiology of the Ocean Crust papers in this special issue bring together recent discoveries of microbial presence, diversity and activity in these dynamic ocean environments. Cumulatively, the articles in this special issue serve as a tribute to the late Dr. Katrina J. Edwards, who was a pioneer and profound champion of studying microbes that “rust the crust”. This special issue volume serves as a foundation for the continued exploration of the subsurface ocean crust deep biosphere
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  • 98
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    Self-Organization in the Nervous System (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889453405
    Language: English
    Pages: 1 Online-Ressource (135 p.)
    Series Statement: Frontiers Research Topics
    Abstract: This special issue review ...
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  • 99
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    Sea Level Variability and Change (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451500
    Language: English
    Pages: 1 Online-Ressource (174 p.)
    Series Statement: Frontiers Research Topics
    Abstract: In June 2015 we held a workshop on the beautiful island of Mallorca, Spain with a focus on sea level variability and change. Over 120 sea level experts from around the world attended this workshop, from a range of different disciplines. The main aims of the workshop were to: 1.) Evaluate the current state-of-knowledge of sea level science; 2.) Identify gaps and unresolved questions in any aspect of sea level science; and 3.) Design future research to address these issue. All aspects of sea level changes were covered, from global to regional, observations and modelling, processes driving mean sea level changes and extremes, from the geological scale to the instrumental era and future projections and including impacts on the coastal zones. This E-Book presents papers that came out of that workshop. Overall, these papers illustrate the multi-disciplinary nature of sea level research, cross-cutting many fields of research including: oceanography, meteorology, geology, coastal morphodynamics, engineering and the social-economic aspects. Collectively, theses articles represent an interesting range of perspectives and original studies that contribute to understanding the dynamic nature of sea level and its impacts across a wide range of time and space scales. Enjoy reading them!
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  • 100
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    The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments (2017)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
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    ISBN: 9782889451463
    Language: English
    Pages: 1 Online-Ressource (336 p.)
    Series Statement: Frontiers Research Topics
    Abstract: Amyotrophic lateral scler ...
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