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  • MPI Ethno. Forsch.  (416)
  • Ethn. Museum Berlin
  • MEK Berlin
  • Basel : MDPI - Multidisciplinary Digital Publishing Institute  (416)
  • Medicine  (416)
Datasource
  • MPI Ethno. Forsch.  (416)
  • Ethn. Museum Berlin
  • MEK Berlin
Material
Language
Years
Author, Corporation
Publisher
Keywords
  • 1
    Online Resource
    Online Resource
    Mental Health and Nursing Care of Individuals with Cancer and Their Families (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036596679 , 9783036596662
    Language: Undetermined
    Pages: 1 Online-Ressource (138 p.)
    Keywords: Medicine ; Latinx ; family ; meaning ; communication ; coping with advanced cancer ; delirium ; liaison nurse ; misrecognition of delirium ; coordination ; breast cancer ; psychological distress ; quality of life ; women’s health ; qualitative study ; cancer care ; older adults ; mental health ; feeling safe ; home-dwelling ; patients with terminal cancer ; caregivers ; competency in anticipatory grief counseling ; emotional care ; person-centered care ; qualitative research ; anxiety ; depression ; family involvement ; hepatocellular carcinoma ; palliative care ; cancer ; decision-making ; nurse ; caregiving self-efficacy ; family caregiver ; oral cancer ; oncology ; nursing ; clinical nurse specialists ; cancer patients ; expanding nurses’ authority ; professionalization ; policy ; education
    Abstract: This collection of articles provides insight into the mental health and nursing care of individuals who are confronting a life-threatening illness. As individuals face a cancer diagnosis, there will be many challenges and changes in their lives. Emotional distress can emerge to greater and lesser degrees. Frequently, these individuals will require additional assistance to cope with the emotional distress they experience. Nurses have an important role in assessing this emotional distress and providing relevant interventions
    Note: English
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  • 2
    Online Resource
    Online Resource
    Diagnosis, Evaluation, and Management of Diseases during Pregnancy (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036597386 , 9783036597393
    Language: Undetermined
    Pages: 1 Online-Ressource (342 p.)
    Keywords: Medicine ; pregnancy ; fetus prenatal care ; high-risk ; pathology
    Abstract: This reprint includes studies on diagnosing, evaluating and managing the pathologies diagnosed during pregnancy. The information provided in these pages is helpful for specialists in obstetrics and gynaecology but also for other medical specialities involved in treating pregnant women with associated pathologies. Studying the articles in the reprint could contribute to improving case management
    Note: English
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  • 3
    Online Resource
    Online Resource
    Ecosystem Observation, Simulation and Assessment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567747 , 9783036567754
    Language: Undetermined
    Pages: 1 Online-Ressource (258 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on ecosystem observation, simulation and assessment. Ecosystems provide supply, regulation, culture and support services for human beings in addition to overall support human survival and sustainable development. However, driven by multiple factors such as climate change, population growth, urbanization, and exploitation of mineral resources, global problems such as ecosystem degradation and biodiversity loss have affected the sustainable development of human beings. Because of this, it has become a hot spot in ecology research to develop basic theories, model methods and technical means for ecosystem observation, simulation and evaluation for the quantitative analysis of the structure, process and function of ecosystems as well as the improvement of the scientific understanding of the changing characteristics and evolution laws of natural ecosystems
    Note: English
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  • 4
    Online Resource
    Online Resource
    Molecular Biology of Disease Vectors (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566979 , 9783036566962
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Oncology
    Abstract: Arthropod disease vectors transmit not only serious diseases, such as malaria, but many other diseases as well, many of which are neglected to various extents. In most cases, a tripartite interaction is involved between the arthropod disease vector, the vertebrate host, and the vector-borne pathogens. The reprint aims to present a selection of the latest data (and up to date information in the case of reviews) about the molecular and biochemical events that mediate this tripartite interaction with emphasis on ticks and mosquitoes
    Note: English
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  • 5
    Online Resource
    Online Resource
    Methodologies Used in Remote Sensing Data Analysis and Remote Sensors for Precision Agriculture (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566146 , 9783036566153
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medicine
    Abstract: When adopting remote sensing techniques in precision agriculture, there are two main areas to consider: data acquisition and data analysis methodologies. Imagery and remote sensor data collected using different platforms provide a variety of information volumes and formats. For example, recent research in precision agriculture has used multispectral images from different platforms, such as satellites, airborne, and, most recently, drones. These images have been used for various analyses, from the detection of pests and diseases, growth, and water status of crops to yield estimations. However, accurately detecting specific biotic or abiotic stresses requires a narrow range of spectral information to be analyzed for each application. In data analysis, the volume and complexity of data formats obtained using the latest technologies in remote sensing (e.g., a cube of data for hyperspectral imagery) demands complex data processing systems and data analysis using multiple inputs to estimate specific categorical or numerical targets. New and emerging methodologies within artificial intelligence, such as machine learning and deep learning, have enabled us to deal with these increasing data volumes and the analysis complexity
    Note: English
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  • 6
    Online Resource
    Online Resource
    Emerging Materials for Additive Manufacturing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036566429 , 9783036566436
    Language: Undetermined
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medicine ; Oncology
    Abstract: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM
    Note: English
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  • 7
    Online Resource
    Online Resource
    Robotic Non-destructive Testing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565293 , 9783036565309
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine
    Abstract: Non-destructive testing and evaluation are commonly referred to as the vast group of analysis techniques used in civil, medical, and industrial sectors to evaluate the properties of materials, tissues, components, or structures, without causing any damage. Automation offers many benefits for non-destructive testing to cope with increasing demands, including improved reliability and higher inspection speeds. Additionally, robots enable inspections in locations that are not easily accessible to human operators and allow for humans to be removed from potentially dangerous environments. However, the perceived complexity and high costs have limited the adoption of automation. As a result, the full potential that could be derived from the seamless integration of robotic platforms with sensors, actuators, and software has not been fully explored; it could still revolutionise the way that automated inspections are performed and conceived. The recent advancements in electronics, robotics, sensor technology and software pave the way for new developments in automated testing and data-driven autonomous robotic inspections in several sectors. This Special Issue aimed to attract the latest research outcomes in the field of robotic sensing. Five papers relate to inspection systems based on robotic fixed-base manipulators, three of which are associated with in-process inspection in manufacturing applications (robotic wire-arc welding and additive manufacturing). Four papers report research advancements in mobile robotic-enabled sensing
    Note: English
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  • 8
    Online Resource
    Online Resource
    Advances in Industrial Robotics and Intelligent Systems (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036565545 , 9783036565552
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Robotics and intelligent systems are key technologies to promote efficient and innovative applications in the most diverse domains (industry, healthcare, agriculture, construction, mobility, etc.), performing and supporting activities that are not suitable to be performed by humans. Such activities are frequently time-consuming, repetitive tasks with low added value, which are physically demanding and/or dangerous. Nevertheless, robotics and intelligent systems face several scientific and technological challenges related to their integration and interoperability with other systems, safety, flexibility, re-configurability and autonomy. These challenges are especially relevant when robots operate in real unstructured environments and share a workspace with humans and other equipment. This reprint collects research achievements, ideas, and applications regarding advanced intelligent robotic systems, covering diverse technologies and application domains. Generically, the contributions cover optimal path-planning strategies and innovative designs for mobile manipulators, the integration of robotic and intelligent systems, grasping, manipulation, teleoperation, haptics, user experience approaches for collaborative robots, and multi-agent systems
    Note: English
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  • 9
    Online Resource
    Online Resource
    Radioactive Pollution and Biological Effects of Radioactivity (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036567679 , 9783036567662
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Neurology & clinical neurophysiology
    Abstract: The Special Issue “Radioactive Pollution and Biological Effects of Radioactivity“of the Journal Life involved the participation of academic scientists, researchers, and scholars from all over the World that contributed with articles, reviews, and case reports, based on high-quality research works.The common topic of the published works concerns the radioactive pollution, which occurs when radioactive elements enter the atmosphere and reach the Earth’s surface, within solids, liquids, or gases, including the human body. This happens after natural and/or man-made activities, such as nuclear tests, industrial waste (e.g., radiodiagnostics), and excesses of naturally occurring radioactive sources. This kind of pollution entails risks of radiological contamination of the environment, with harmful effects on human health caused by the ionizing radiation. This theme has become even more current due to the increasing use of ionizing radiation for domestic, industrial, and medical purposes during the last century. Radiological monitoring is a primary objective of radiation protection in order to estimate and understand the impact of radionuclides on the environment and to assess the health risk for the population.The aim of the Special Issue has been to provide an interdisciplinary platform for researchers to exchange and share their experiences and latest achievements on all aspects of radioactive pollution. Survey data analysis, original and unpublished results of conceptual, constructive, empirical, experimental, and theoretical work were welcome, as well as other concepts related to the radiation field
    Note: English
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  • 10
    Online Resource
    Online Resource
    Osteoporosis and Related Bone Metabolic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036563480 , 9783036563497
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Many heterogeneous causes (e.g., metabolic, inflammatory, autoimmune, vascular, and renal diseases, and even drugs), collectively grouped as secondary causes of osteoporosis, may lead to bone loss or damage to architecture through a number of mechanisms. Although these secondary causes of osteoporosis are the most frequently observed causes of unexpected bone loss, they can only be diagnosed via a high degree of suspicion and clinical experience and by performing the appropriate investigations. In inflammatory disorders such as rheumatoid arthritis or chronic inflammatory bowel diseases, as well as vascular diseases, T-cell activation, and consequently pro-inflammatory cascades, trigger the increased expression of T-cell-derived RANKL. In addition, a new biomarker signature of bone-related miRNAs is promising in certain clinical features. Glucocorticoids, often used to control disease activity, decrease the number and function of osteoblasts and inhibit OPG expression. The ubiquitous occurrence of disease-related secondary changes in bone metabolism implies that numerous medical disciplines need to interact. Screening for secondary causes of osteoporosis and the search for new modes of action should present a substantial aspect of osteoporosis management. In the book, the current management of osteoporosis and related metabolic bone diseases is discussed
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  • 11
    Online Resource
    Online Resource
    Orthopedic Treatment of Diseases and Fractures in Elderly (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593586 , 9783036593593
    Language: Undetermined
    Pages: 1 Online-Ressource (256 p.)
    Keywords: Medicine
    Abstract: Elderly frailty represents the poor resolution of homeostasis following stress and an increased risk of adverse outcomes, including falls, delirium and disability. This reprint is focused on the diagnosis and treatment of fractures and orthopedic diseases among elderly people. In particular, this concerns medical, orthopaedics and rehabilitative factors. This reprint includes original articles, narrative or systematic reviews and meta-analysis, aiming to provide readers with the correct approach to these pathologies
    Note: English
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  • 12
    Online Resource
    Online Resource
    Sports or/and Special Populations: Training Physiology in Health and Sports Performance (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590530 , 9783036590523
    Language: Undetermined
    Pages: 1 Online-Ressource (306 p.)
    Keywords: Medicine ; Physiology
    Abstract: Several factors have been identified as interfering with the success, rehabilitation, and fitness of athletes from childhood to adulthood, as well as in para-sport, and special populations, according to research. The performance and health of this population are affected by the relationships between stress, maturation, training load, and recovery. Environmental approaches aim to increase efficiency and physiological adaptations in this sense. In various situations and conditions, however, this stimulus–performance–adaptation relationship varies.As a result, we received contributions related (but not limited) to the following topics: training load monitoring; stress and physiological responses during exercise or sports; recovery process after exercise; changes after stress and/or training load; physiology of training in health and sports performance
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  • 13
    Online Resource
    Online Resource
    Clinical Features of COVID-19 in Elderly Patients (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593043 , 9783036593050
    Language: Undetermined
    Pages: 1 Online-Ressource (198 p.)
    Keywords: Medicine
    Abstract: This reprint "Clinical Features of COVID-19 in Elderly Patients" is a crucial resource dedicated to the medical challenges posed by the pandemic, with a specific focus on its impact on elderly people. Given their vulnerability, understanding the clinical aspects of COVID-19 in this demographic is paramount. This reprint compiles a wide array of studies and current knowledge tailored to address the unique challenges faced by elderly people during the pandemic. It surpasses literature reviews, offering critical analysis and in-depth discussions. Its primary goal is to encourage critical analyses and discussions about the clinical characteristics of COVID-19 in elderly people. Targeted towards medical professionals, researchers, and healthcare practitioners, it aids in the development of tailored treatment approaches and care protocols. As the COVID-19 pandemic persists, this reprint remains essential for those dedicated to combating the virus, enhancing elderly patients’ care, and promoting public health
    Note: English
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  • 14
    Online Resource
    Online Resource
    Clinical Advances in the Diagnosis and Treatment of Biliary Tract Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593180 , 9783036593197
    Language: Undetermined
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Medicine
    Abstract: In recent years, there have been remarkable advances in the diagnosis and treatment of biliary tract diseases. Among them, the advanced endoscopic treatments and anti-tumor therapies for biliary tract cancer are outstanding. This reprint contains the latest research articles and review articles focusing on the diagnosis and treatment of biliary tract diseases using endoscopic retrograde cholangiopancreatography (ERCP) or endoscopic ultrasounds (EUSs) for biliary stricture, cholecystitis, cholangitis, ampullary tumors, and chemotherapy for biliary tract cancer
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  • 15
    Online Resource
    Online Resource
    Dietary Patterns, Physical Activity, and Lifestyle in the Onset, Prevention, and Management of Noncommunicable Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036595504 , 9783036595511
    Language: Undetermined
    Pages: 1 Online-Ressource (204 p.)
    Keywords: Medicine
    Abstract: This Special Issue includes 12 articles, consisting of original research, narrative reviews, systematic reviews, and an editorial regarding the roles of dietary and lifestyle factors in the prevention and mangement of noncommunicable diseases. Studies in this Special Issue cover a range of topics including dietary patterns and diseases risk and prevention, the association of lifestyle factors and disease risk, the role of vitamin D and solar radiation in health and pregnancy, and urbanization in modifying risk of adverse health outcomes for various noncommunicable diseases
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  • 16
    Online Resource
    Online Resource
    Gastrointestinal Malignancies: Screening, Diagnosis, and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593869 , 9783036593876
    Language: Undetermined
    Pages: 1 Online-Ressource (154 p.)
    Keywords: Medicine
    Abstract: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies
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  • 17
    Online Resource
    Online Resource
    Frontiers in Vascular Stiffness (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593302 , 9783036593319
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and clinically suitable. This Special Issue focuses on new methodological advances in vascular stiffness, as well as preclinical and clinical applications. A privileged space is reserved for new data and targeted reviews of the application of arterial stiffness and early vascular ageing measures regarding problems such as the stratification of risk of special populations and specific diseases
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  • 18
    Online Resource
    Online Resource
    Nursing and COVID-19 Ⅰ (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590707 , 9783036590714
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine
    Abstract: Nurses represent the highest number of healthcare workers globally and have played a critical role in the COVID-19 pandemic. This reprint highlights the issues and challenges faced by nurses practicing in hospital and community settings during the COVID-19 pandemic. The manuscripts herein focus on nurses in various areas of practice, including nurse managers, highlighting the impact, experience, and reality of providing care during the crisis. Interventions and strategies to support practice environments and the mental health and wellbeing of the nursing workforce were identified. Evidence from these manuscripts shed light on how nurse leaders can provide relevant, coordinated, and consistent organizational and leadership support to better establish a safe and healthy work environment that protects and fosters the mental health and wellbeing of all nursing personnel. The pandemic exacerbated the already demanding quality of work environments for nurses, as well as their mental health and wellbeing, thereby inducing a global nursing shortage; therefore, improving these factors, which ultimately influence nurse retention, is critical. We trust that sharing the lived experiences of nurses during the COVID-19 pandemic can enable us to leverage their expertise in meeting the complex care needs of patients, including COVID-19 patients, while improving the care needed by nurses in their working environments, alongside preparing for future pandemic waves
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  • 19
    Online Resource
    Online Resource
    Ophthalmic Drug Delivery, 2nd Edition (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036587998 , 9783036587981
    Language: Undetermined
    Pages: 1 Online-Ressource (316 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Research in ophthalmic drug delivery has developed significant advances in the few last years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies
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  • 20
    Online Resource
    Online Resource
    Translational Research in Audiology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591612 , 9783036591605
    Language: Undetermined
    Pages: 1 Online-Ressource (128 p.)
    Keywords: Medicine
    Abstract: This collection brings together basic and clinical research papers that cover different topics in audiology but have one thing in common: the translational approach. The research in this collection demonstrates how exciting and interesting translational audiology can be. This collection aims to stimulate interest and encourage more studies of this type
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  • 21
    Online Resource
    Online Resource
    Recent Advances and Future Challenges in Gastroenterology and Hepatology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589404 , 9783036589411
    Language: Undetermined
    Pages: 1 Online-Ressource (268 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Gastroenterology and hepatology are fields of research that have improved considerably in recent years in terms of clinical approach, diagnosis, and therapy. However, there is still much to be clarified and explored, and many questions remain unanswered. Therefore, basic research, including translational and clinical discoveries, supported by technological innovations such as artificial intelligence, will enable further steps toward better, more refined treatments for many digestive diseases. The challenge of modern medicine will therefore be to connect these two fields to ensure optimal patient management. Further innovations will help clinicians to improve clinical practice, establish new guidelines, and provide personalized treatment based on patient characteristics. The aim of this Special Issue is to highlight recent advances and future challenges in gastroenterology and hepatology
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  • 22
    Online Resource
    Online Resource
    Efficiency in Kinesiology: Innovative Approaches in Enhancing Motor Skills for Athletic Performance (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036587790 , 9783036587783
    Language: Undetermined
    Pages: 1 Online-Ressource (182 p.)
    Keywords: Medicine
    Abstract: This Special Issue dives into the evolving realm of sports science by exploring innovative methods to enhance athletes' motor skills and performance. It showcases research studies aiming to discover validated strategies, cutting-edge approaches, and the intricate interplay of factors that shape athletic excellence. From training methodologies to technological advancements, this collection of empirical investigations and reviews offers valuable insights for both trainers and scientists. We invite readers to join us in uncovering the science behind peak athletic achievement
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  • 23
    Online Resource
    Online Resource
    Head and Neck Surgery: Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592480 , 9783036592497
    Language: Undetermined
    Pages: 1 Online-Ressource (164 p.)
    Keywords: Medicine
    Abstract: As Guest Editors, we are very delighted to see the reprint of our Special Issue, “Head and Neck Surgery: Clinical Updates and Perspectives", which is published in the Otolaryngology section of the Journal of Clinical Medicine. These papers are the joint effort of many excellent colleagues who have devoted their lives and careers to the exciting field of Otorhinolaryngology. As both clinicians and surgeons, we are actively advancing the diagnosis and management of the myriad of conditions affecting the head and neck region. Unprecedented discoveries in the field of genetics and molecular biology are always integrated with sound knowledge of the intricate anatomy of our discipline, while technological advancements now permit us to provide tailored and minimally invasive treatments for our patients. We wish to thank all the authors who contributed to this publication and we hope you enjoy reading it
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  • 24
    Online Resource
    Online Resource
    Aortic Aneurysms: Vascular Remodeling and Repair (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589022 , 9783036589039
    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: Aortic aneurysm is a multifactorial progressive life-threatening disease. Recent surgical treatment and endovascular repair help to prevent aortic ruptures. However, there are no effective pharmacological treatments to limit aneurysm growth. This Special issue, entitled “Aortic Aneurysms: Vascular Remodeling and Repair", represents a collection of articles from innovative scientists that focuses on the recent advances in diagnostics, pathogenesis and therapies of aneurysms. This reprint includes a systematic review and nine original papers on clinical imaging, prognostic methods, genome-wide screening, novel cell signaling pathways and drug targets. We hope that readers will gain a deeper understanding of this topic and enjoy reading this reprint
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  • 25
    Online Resource
    Online Resource
    Diversity of Marine Fungi as a Source of Bioactive Natural Products (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591667 , 9783036591674
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Bioactive metabolites from marine-derived fungi are known to be an important source of drug discoveries. Natural product scientists have explored various environments, such as the deep ocean and polar regions, as well as marine mangrove ecosystems, to discover unique fungi strains which could produce new bioactive structures. The aim of this Special Issue is to highlight the diversity of fungi derived from different marine environments, as well as their potential as producers of bioactive marine natural products. Innovative scientific results, as well as approaches and methodologies applied in marine natural product discovery areas, are encouraged. Studies on the biosynthesis and bioactivities of marine natural products are also welcome. For this Special Issue, we invited academic and industry scientists to submit reviews and original and conceptual research articles highlighting diversified marine fungi as a source of bioactive natural products
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    Recent Advances in Diagnosis and Treatment of Vestibular Disorders (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591100 , 9783036591117
    Language: Undetermined
    Pages: 1 Online-Ressource (184 p.)
    Keywords: Medicine
    Abstract: Vestibular medicine relates to the assessment, diagnosis, and treatment of patients with dizziness and vertigo. In all these fields, there has been an enormous increase in research during recent years. This edition includes a discussion on the epidemiology of dizziness, the role of genetics in the development of vestibulopathy, diagnostic approaches, and interventions for patients with dizziness and vertigo: medical treatment, surgery, and vestibular rehabilitation
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    Diagnosis, Treatment, and Management of COPD and Asthma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589657 , 9783036589640
    Language: Undetermined
    Pages: 1 Online-Ressource (286 p.)
    Keywords: Medicine
    Abstract: Chronic obstructive pulmonary disease (COPD) is a disorder characterized by airflow limitation and is one of the major causes of mortality and morbidity across the globe. Although several guidelines have been published over the past three decades, they were generated in response to the fact that COPD is a major cause of mortality and morbidity and remains an important social problem. In the 20th century, forced expiratory volume in one second (FEV1) was the single most important measure in patients with COPD from discriminative, evaluative, and predictive standpoints. We found that dyspnea is a better mortality predictor than FEV1 in 2002 and exercise capacity in 2003. Subsequently, it has become apparent that physical activity is more predictive of mortality. Furthermore, we have recently developed the tendency to use the reduction of the future risk of exacerbation as the endpoint of relatively large-scale clinical trials rather than the improvement of FEV1. Many researchers have continued to seek better outcome markers and have also discussed what should be used as primary or secondary endpoints in clinical trials in subjects with COPD. We have undoubtedly made great progress but still have a lot of work to do for the best interests of patients
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    Nursing and COVID-19 Ⅱ (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591940 , 9783036591957
    Language: Undetermined
    Pages: 1 Online-Ressource (394 p.)
    Keywords: Medicine
    Abstract: Nurses represent the highest number of healthcare workers globally and have played a critical role in the COVID-19 pandemic. This reprint highlights the issues and challenges faced by nurses practicing in hospital and community settings during the COVID-19 pandemic. The manuscripts herein focus on nurses in various areas of practice, including nurse managers, highlighting the impact, experience, and reality of providing care during the crisis. Interventions and strategies to support practice environments and the mental health and wellbeing of the nursing workforce were identified. Evidence from these manuscripts shed light on how nurse leaders can provide relevant, coordinated, and consistent organizational and leadership support to better establish a safe and healthy work environment that protects and fosters the mental health and wellbeing of all nursing personnel. The pandemic exacerbated the already demanding quality of work environments for nurses, as well as their mental health and wellbeing, thereby inducing a global nursing shortage; therefore, improving these factors, which ultimately influence nurse retention, is critical. We trust that sharing the lived experiences of nurses during the COVID-19 pandemic can enable us to leverage their expertise in meeting the complex care needs of patients, including COVID-19 patients, while improving the care needed by nurses in their working environments, alongside preparing for future pandemic waves
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    Clinical Research Advances in Congenital Heart Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594323 , 9783036594330
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Though the number of infants born with heart disease each year is relatively small (approximately 1% of the population), it is still a substantial issue worthy of investigation, which is why this Special Issue focuses on congenital heart disease in both children and adults. Advances in the treatment of such malformations have led to increased life spans for this population. Consequently, today, most patients treated for congenital heart disease are adults. The purpose of this Special Issue is to deal with the latest developments in the care of the fetus, infants and children, and how these patients should be treated, as well as to describe the results of follow-ups and the potential special needs of adults with congenital heart disease
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    Roles of MET in Cancer Development and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036595306 , 9783036595313
    Language: Undetermined
    Pages: 1 Online-Ressource (240 p.)
    Keywords: Medicine
    Abstract: Understanding the impact of the hepatocyte growth factor receptor (MET) during cancer development, cancer growth, and cancer treatment is crucial to further improve biomarker development and cancer treatment options for patients' benefit. This reprint gives a snapshot of the current understanding of MET in lung and gastric cancer, describes promising new therapeutics, and emphasizes some of the challenges associated with their use
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    Atopic Dermatitis: Research and Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592046 , 9783036592053
    Language: Undetermined
    Pages: 1 Online-Ressource (172 p.)
    Keywords: Medicine
    Abstract: This Special Issue on Atopic Dermatitis focuses on novel insights into the pathogenesis of the immunological components of the disorder and the impaired epidermal barrier properties. It also explores the efficacy and safety of breakthrough therapies with topical agents and systemic therapies, such as monoclonals and JAK inhibitors. The aim of this Special Issue is also to present the expected future forefront of research and the treatment options that are expected to be available in the next few years
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    Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589381 , 9783036589398
    Language: Undetermined
    Pages: 1 Online-Ressource (188 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic
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    Fatty Acids from Marine Organisms (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590882 , 9783036590899
    Language: Undetermined
    Pages: 1 Online-Ressource (206 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Fatty acids (FAs) are considered very important biomolecules because they have been used as trophic biomarkers in the marine food chain analysis of several ecological niches. They are compounds universally present in all organisms and play very important biological roles, such as acting as building blocks in biological membranes and signaling molecules. A great number of different fatty acids (saturated, mono- and di-unsaturated, branched, halogenated, hydroxylated, and methoxylated), as well as the major polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, occur in marine organisms. In addition, marine organisms are a rich source of metabolites with unusual structures that often exhibit interesting pharmacological properties. Moreover, it is worth emphasizing that the nutritional value of fish and marine invertebrates directly depends on their lipid composition and, in particular, their fatty acid profile, and this represents the basis of the trade of most international marine products. For this Special Issue, we invited academic and industry scientists to submit reviews and original research articles focusing on the chemistry, biological roles, and bioactivities of fatty acids from marine organisms
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    Drug Delivery across Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036590417 , 9783036590400
    Language: Undetermined
    Pages: 1 Online-Ressource (202 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The reprint is a collection of original articles and reviews in the field of modern drug delivery systems and strategies for efficient drug transport across various biological barriers, including the blood–brain barrier, mucosal and endothelial barriers, and cell membranes
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    Inflammation and Natural Products (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594774 , 9783036594767
    Language: Undetermined
    Pages: 1 Online-Ressource (338 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Terrestrial and marine environments are inexhaustible sources of compounds and active extracts which have been employed in medicine since ancient times. The aim of this reprint is to collect new approaches around compounds and extracts isolated from natural products and their biological activity, with a focus on anti-inflammatory pathways. Thus, this reprint compiles full original papers and reviews articles published during 2023 in a Special Issue of Life, titled “Inflammation and Natural products”. The publications within this reprint are focused on secondary metabolites of plants demonstrating significant antioxidants and anti-inflammatory properties, among others, and clinical relevance in various pathological conditions. It also includes reviews that focus on natural therapies for topics such as arthritis, lung diseases, neuroprotection, skin photoprotection, and the impact of gender in the use of medicinal plants in relation to vascular diseases. The reprint of this Special Issue will serve as a reference text for researchers and academics, as well as those studying natural products and their pharmacological activities
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    Clinical Research on Type 2 Diabetes and Its Complications (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594187 , 9783036594194
    Language: Undetermined
    Pages: 1 Online-Ressource (322 p.)
    Keywords: Medicine
    Abstract: The huge prevalence of type 2 diabetes is a leading human and economic concern worldwide. The diagnosis code of type 2 diabetes includes multiple clinical phenotypes showing different degrees of obesity, fat distribution patterns, types of dyslipidemia, and characteristics of insulin resistance syndrome. In addition, subjects with type 2 diabetes could develop different clinical trajectories, with age being a critical factor in progression. The chronic complications of type 2 diabetes are a major cause of mortality and disability, and are ranked in the top places in western countries’ scores. The pathophysiological heterogeneity of type 2 diabetes is not captured by the current classifications and guidelines. The potential for diabetes progression and complications developing is different depending on the type 2 diabetes cluster, which is mostly regardless of the degree of glycemic control. However, the impact on quality and life expectancy with the current therapeutic approach is not always the same for every individual. Clinical research is the key to reducing the burden of diabetes. New basic, digital, and clinical approaches are obtaining useful knowledge and designing more individualized interventions to prevent, track, and treat diabetic complications. This Special Issue is a clear reflection of this methodological evolution
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    Clinical Pharmacology and Pharmacy of Antimicrobial Agents (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591094 , 9783036591087
    Language: Undetermined
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: In this Special Issue, our aim was to collect studies on clinical pharmacology and pharmacy of antimicrobial agents from both human and veterinary medicine as the complex problem of AMR requires actions taken within the One Health approach that involve both fields. Studies covered here are about new or optimized usage of already authorized antimicrobials, as well as discoveries about new agents, new combinations of drugs, and drug repositioning. Pharmacodynamic, pharmacokinetic, and toxicological aspects of individual and combinational drug use are areas covered in this Special Issue
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    PET/CT Imaging in Oncology: Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594507 , 9783036594514
    Language: Undetermined
    Pages: 1 Online-Ressource (180 p.)
    Keywords: Medicine
    Abstract: This reprint focuses on the most recent advances in PET/CT imaging within the field of oncology. These innovations include studies on novel or experimental tracers, such as [18F]FES for the imaging of advanced breast cancer and [68Ga]Ga-Nitroimidazole for visualizing hypoxic tumour components; research on new radiopharmaceuticals represents, in fact, one the most important study fields of PET research. Advanced image analysis, such as radiomics, is also featured in this reprint; this method has been applied to both traditional nuclear medicine clinical issues, such as thyroid nodules, as well as in the setting of new therapeutic approaches, such as CAR-T cell therapy. Finally, the theranostic implications of PET radiotracers and the diagnostic processes of rare tumours are explored in this reprint
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  • 39
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    Pediatric Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036590240 , 9783036590257
    Language: Undetermined
    Pages: 1 Online-Ressource (456 p.)
    Keywords: Medicine ; Oncology
    Abstract: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies
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    Multidisciplinary Approach to Oral Cancer: The Way to Improve Expectancy and Quality of Life (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592442 , 9783036592459
    Language: Undetermined
    Pages: 1 Online-Ressource (226 p.)
    Keywords: Medicine
    Abstract: The growing improvement of medical sciences in the diagnosis and treatment of head and neck oncological diseases has produced a significant increase in the life expectancy of affected patients. it is therefore necessary to direct new energies towards understanding and protecting the quality of life of cancer patients. This reprint presents the fruit of the research protocols of numerous groups around the world on the topics of life expectancy and quality of life of patients suffering from head and neck cancer
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    Advance in Orthopedic Trauma Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036591766 , 9783036591773
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: The field of orthopedic trauma has always been a discipline cahacterized by rapid innovation and creative evolution. We see evolution in every facet of orthopedic surgery, ranging from the transformation of the understanding of implant design and biomechanics to the understanding and monitoring of fracture healing and the management of complications. This Reprint includes many articles discussing topics, such as distal radius fractures, hip fractures, osteoarthritis, ankle fractures, acetabular fractures, and anterior cruciate ligament reconstruction
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  • 42
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    Ophthalmic Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036587974 , 9783036587967
    Language: Undetermined
    Pages: 1 Online-Ressource (330 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies
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    Advances in Cardiac Electrophysiology and Pacing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036590783 , 9783036590790
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Today, interventional treatment and clinical management of cardiac arrhythmias represent a continuous challenge. This is mainly due to the widening of indications for implantable electronic devices and for catheter ablation procedures as well as the continuous improvement of technologies and medical therapies. Despite international guidelines and worldwide consensus updates, evidence gaps persist at all points in the real-world setting. This Special Issue aims to provide a comprehensive overview of advances in the indications, diagnosis, and treatment of cardiac rhythm disturbances, with particular interest in the use of innovative techniques and technologies in interventional therapies
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    Genomics of Rare Hematologic Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036589565 , 9783036589572
    Language: Undetermined
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medicine
    Abstract: The primary aim of this reprint is to describe the genomics of splenic lymphomas, hairy cell leukemia, Cutaneous lymphomas, plasma cell leukemia, MDS with deletion 5q, mastocytosis, hypodiploid acute lymphoblastic leukemia, CLL with complex karyotype and other rare hematologic cancers
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  • 45
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    Optical Coherence Tomography Imaging: Advances in Ophthalmology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592503 , 9783036592510
    Language: Undetermined
    Pages: 1 Online-Ressource (254 p.)
    Keywords: Medicine
    Abstract: The advent of optical coherence tomography (OCT) has arrived in an era in which the in vivo, cross-sectional imaging of both the retina and choroid is possible. Infra-red rays of light are used to image the chorioretinal layers with an image resolution reaching 10-15 microns. During the last three decades, OCT technology has undergone several improvements, such as spectral domain OCT (SD-OCT), swept source OCT (SS-OCT), enhanced depth imaging (EDI-OCT), wide field OCT, intraoperative OCT, OCT angiography (OCTA), and adaptive optics OCT. These enhancements help in both the qualitative and quantitative analysis of chorioretinal parameters in pathologies such as macular edema, neurosensory detachment, retinoschisis, macular holes, epiretinal membranes, and choroidal tumors. An added advantage is the role of OCT in the evaluation of optic disc disorders, including optic neuritis and glaucoma, via the quantitative analysis of the retinal nerve fiber layer. Moreover, OCT being non-invasive provides an opportunity for serial imaging during follow-up visits. Overall, OCT imaging provides tissue details, closely mimicking the histopathology, and is an invaluable asset in the armamentarium of retina physicians. This special issue includes applications of OCT in various chorioretinal disorders
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    Diagnosis and Treatment for Hepatocellular Tumors (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036593203 , 9783036593210
    Language: Undetermined
    Pages: 1 Online-Ressource (330 p.)
    Keywords: Medicine
    Abstract: Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 〉80% of primary liver cancers worldwide. The diagnosis of HCC, relying solely on noninvasive criteria, is currently under debate due to the need for molecular information that necessitates tissue biopsies, while therapy is provided in accordance with tumor stages and the anticipated advantages of major interventions, following the Barcelona Clinic Liver Cancer (BCLC) staging system. Principally, resection, transplantation and local ablation are most commonly performed in patients with early-stage HCC tumors, while TACE and systemic therapy are, respectively, the preferred treatment options for intermediate- and advanced-stage tumors. However, the HCC tumor immune microenvironment (TME) affects the response to current anti-PD-1/PD-L1 immunotherapies. Therefore, an enhanced understanding of the immunobiology of TME is essential for the development of predictive biomarkers of patient stratification and strategies of drug combinations to improve therapeutic efficacy, especially for patients with tumors that are unresponsive to anti-PD-1/PD-L1 therapy. Taking into account the health burden of HCC worldwide, with this Special Issue, we aim to enhance our knowledge of innovative diagnostic and prognostic methods and to discuss experimentation with different novel treatment modalities, believed to be of the utmost priority to progress in our seemingly never-ending fight against hepatocellular cancer
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    Bariatric Surgery: Latest Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594583 , 9783036594590
    Language: Undetermined
    Pages: 1 Online-Ressource (464 p.)
    Keywords: Medicine
    Abstract: This reprint is a compilation of cutting-edge knowledge in the field of bariatric surgery. It addresses the growing obesity epidemic and provides in-depth insights into the latest innovations in bariatric surgery and its future prospects. The content of the work includes a comprehensive review of modern surgical techniques. Additionally, it explores key aspects of preoperative assessment, postoperative follow-up, and the management of potential complications. The reprint highlights the benefits of bariatric surgery in improving the health and quality of life of morbidly obese patients. The reprint also addresses emerging trends in research and technology, such as robotic surgery and gene therapy, which hold the promise of further revolutionizing the field
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  • 48
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    Computer Aided Diagnosis Sensors (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036595320 , 9783036595337
    Language: Undetermined
    Pages: 1 Online-Ressource (670 p.)
    Keywords: Medicine
    Abstract: Sensors used to diagnose, monitor or treat diseases in the medical domain are known as medical sensors. There are several types of medical sensors that can be utilized for various applications, such as temperature probes, force sensors, pressure sensors, oximeters, electrocardiogram sensors that measure the electrical activity of the heart, heart rate sensors, electroencephalogram sensors that measure the electrical activity of the brain, electromyogram sensors that record electrical activity produced by skeletal muscles, and respiration rate sensors that count how many times the chest rises in a minute. The output of these sensors used to be interpreted by humans, which was time consuming and tedious; however, such interpretations became easy with advances in artificial intelligence (AI) techniques and the integration of the sensor outputs into computer-aided diagnostic (CAD) systems. This reprint presents some of the state-of-the-art AI approaches that are used to diagnose different diseases and disorders based on the data collected from different medical sensors. The ultimate goal is to develop comprehensive and automated computer-aided diagnosis by focusing on the different machine learning algorithms that can be used for this purpose as well as novel applications in the medical field
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    Breast Cancer—Therapeutic Challenges, Research Strategies and Novel Diagnostics (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594439 , 9783036594422
    Language: Undetermined
    Pages: 1 Online-Ressource (282 p.)
    Keywords: Medicine
    Abstract: Thanks to the breast cancer research of recent decades, effective methods and strategies have been established, allowing the mortality rates of breast cancer patients to decrease more and more. However, we still face many challenges. The role of certain biomarkers or mutations is still not clear for treatment and surveillance. Novel drugs are often associated with a different spectrum of adverse events than that seen for conventional therapies, accordingly having an impact on patients’ compliance behaviors. In breast cancer surgery, in some cases, the question remains whether to escalate or deescalate. Additionally, with regard to diagnostics, in a digitalized world, home-based tools and therapy monitoring options are of high importance, especially under the tough conditions and supply problems seen during the COVID-19 pandemic.This Special Issue gathers original research articles and reviews demonstrating therapeutic challenges, current research strategies, and novel diagnostics in breast cancer
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    Advances in Postoperative Pain Management and Chronic Postoperative Pain (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592725 , 9783036592732
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies
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    Novel Diagnostic and Therapeutic Approaches in Temporomandibular Disorders (TMDs) and Myofascial Pain (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592954 , 9783036592947
    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Medicine
    Abstract: This Special Issue aimed to cover a diverse scope of topics, from diagnostics to the management of temporomandibular disorders and myofascial pain, with a special focus on innovations in those areas. Intense research progress in the subject as well as technological development, access to knowledge, and novel digital tools allow developing more precise, reproducible, and dedicated diagnostic and therapeutic protocols
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    Therapeutic Landscapes in Colorectal Carcinoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036594415 , 9783036594408
    Language: Undetermined
    Pages: 1 Online-Ressource (142 p.)
    Keywords: Medicine ; Oncology
    Abstract: The Special Issue, titled “Therapeutic Landscapes in Colorectal Carcinoma”, illustrates a stimulating collection of articles written by international specialists that can promote discussions and ideas among colleagues working on CRC. It provides us with a deeper insight into the latest advances involving knowledge on CRC from scientific, translational, and clinical points of view. Through this Special Issue, our main purpose was to shed light on some state-of-the-art research on CRC. Here, the reader will find papers on prognostic factors as well as responses to neoadjuvant and adjuvant CRC treatments. Finally, we discuss the research trends and hotspots for CRC therapies that emerged during the COVID-19 pandemic, such as the potential achievement of a transition from CRC clinical research to precision medicine, together with a special emphasis given to new single-cell-based techniques. We hope that it can encourage translational and interdisciplinary collaborations, leading to a definitive understanding of strategies to overcome and inhibit CRC progression and metastasis
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    Iron Metabolism, Redox Balance and Neurological Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036588445 , 9783036588452
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: With the aging of the population, the incidence rate and number of elderly nervous system diseases have increased sharply. This event has brought huge problems to society. Despite significant efforts being made to explore new treatment options and drugs, the results have been limited. The reason may be due to people's incomplete understanding of the pathogenesis of these age-related diseases. Iron is the most abundant trace element in the human body and is essential for normal life activities. Previous studies have shown that brain iron levels increase with age. The abnormal increase in brain iron levels is closely related to age-related neurological diseases. The disruption of the redox balance may be an important mechanism for the occurrence of neurological diseases caused by brain iron abnormalities. This Special Issue mainly highlights and discusses the latest research progress related to the regulation of brain iron metabolism, redox balance, and the pathogenesis of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebral ischemia, cancer and maintenance of cellular stemness. The molecular mechanisms of iron-misregulation-induced redox imbalance in disease pathogenesis were analyzed. On this basis, further discussions were conducted on potential therapeutic targets for regulating iron metabolism to achieve effective intervention in elderly neurological diseases
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    Going for Gaps in Glaucoma (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594880 , 9783036594897
    Language: Undetermined
    Pages: 1 Online-Ressource (166 p.)
    Keywords: Medicine
    Abstract: Glaucoma is a major cause of blindness that can be prevented if detected and treated in the early stages of the disease. This reprint includes original research studies and reviews that focus on strategies to help identify and treat patients with glaucoma more effectively, improve their treatment adherence, review the potential impact of psychopharmacological therapy on intraocular pressure, and increase knowledge of potential treatment targets for neuroprotection
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    Application of Retinal and Optic Nerve Imaging in Clinical Medicine 2.0 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036591803 , 9783036591810
    Language: Undetermined
    Pages: 1 Online-Ressource (114 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: This reprint discussed the role of retinal and optic nerve imaging in addition to its application in ophthalmic diseases and clinical medicine. It includes some high-quality articles containing original research results as well as review articles of exceptional merit
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    Omics Approaches to Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036592763 , 9783036592770
    Language: Undetermined
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Medicine
    Abstract: Chronic immune-mediated inflammatory diseases (IMIDs), usually accompanied by cardiovascular disease and neoplasias, are now prevailed worldwide. The limited efficacy of current therapeutics and a proportion of non-responders are linked to missing aspects in their pathophysiology at the molecular and cellular levels. High-throughput single- and multi-omics approaches and their combinations are expected to pinpoint the key players underlying IMIDs’ establishment and/or progression, thus suggesting potential therapeutic targets and biomarkers. This Reprint gathered 13 papers presenting recent relevant data related to the assessment of CVD risk in RA, tailored therapeutics in RA-interstitial lung disease, IgG4-related RA, and Sjögren’s syndrome, enabling early identification of PsA and improving outcomes in patients’ with psoriasis. Also, novel non-invasive biomarkers for endoscopic activity and mucosal healing in ulcerative colitis, IBD, and cell-death-associated inflammatory syndromes are proposed. Moreover, a certain subset of telocytes is suggested as the pilot governor of epithelial behavior in preneoplastic gastric lesions, a newer member of IL-1 family, as it is a critical partner in lung adenocarcinoma, while distinct transcriptomic signatures and pathway profiles in human melanocytes corresponding to different Staphylococcal superantigenic enterotoxins are possible targets for therapeutic intervention in cases of toxic shocks. Lastly, Tregs- and dendritic cell-based IMID biomarkers are recommended to enable at more efficient, personalized, and precise treatment strategies
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    Anesthetic Management in Perioperative Period (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036593661 , 9783036593678
    Language: Undetermined
    Pages: 1 Online-Ressource (462 p.)
    Keywords: Medicine
    Abstract: There are a variety of anesthetic management options during surgery, and these are constantly evolving. Both innovative and confirmatory research are important if the scientific community aims to develop and improve people’s quality of care. This reprint introduces new avenues and covers questions regarding innovative anesthetic techniques and unmet needs after surgery, paving the way for future improvements. It can be useful for both clinicians and clinical researchers, especially in light of the expansion of concepts like personalized care
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    Bioactive Secondary Metabolites of Marine Fungi (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036590868 , 9783036590875
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: The Special Issue “Bioactive Secondary Metabolites of Marine Fungi” gathered ten publications, including two reviews and eight research articles, about marine fungi, ranging from the isolation and structure elucidation of new natural products to the biosynthetic pathways of marine fungal metabolites
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    Current Trends in Otorhinolaryngology and Head and Neck Pathology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036592640 , 9783036592657
    Language: Undetermined
    Pages: 1 Online-Ressource (270 p.)
    Keywords: Medicine
    Abstract: Otorhinolaryngology and head and neck specialists worldwide face an increasing incidence and prevalence of various pathologies, some of the cases neglecting the evolution of their condition during the period of COVID-19 pandemics, thus aggravating their evolution. This Special Issue contains reviews and selected rare case series to update the protocols of ENT and allied specialists worldwide. The aim was to present an interdisciplinary point of view of the numerous branches of pathology that form the otorhinolaryngology specialty
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    Cell Therapy, Bispecific Antibodies and other Immunotherapies Against Cancer (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036595665 , 9783036595672
    Language: Undetermined
    Pages: 1 Online-Ressource (194 p.)
    Keywords: Medicine ; Oncology
    Abstract: This Special Issue in Cancers is focused on cell therapy, bispecific antibodies, and other immunotherapies against cancer. It includes reports on cell therapies such as CAR-NK cell therapies, and bispecific antibodies against multiple myeloma and B cell lymphoma. Immunotherapies against solid tumors include TGF-beta-PDL-1 fusion protein and EpCAM-CD3 bispecific antibody generated with mRNA-lipid nanoparticles (LNP) against colorectal tumors. The clinical studies ongoing with bi- and tri-specific T cell engager antibodies against solid tumors and advantages versus cell therapies are discussed. This Special Issue highlights novel approaches to cell therapies, bispecific antibodies, vaccines, and immunotherapies that will be interesting for cancer cell researchers, biologists, and oncologists
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    Physical Activity, Exercise Testing and Clinical Assessment in Sports Medicine (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594545 , 9783036594552
    Language: Undetermined
    Pages: 1 Online-Ressource (370 p.)
    Keywords: Medicine
    Abstract: Physical activity and exercise testing are two key points in sports medicine. Sports medicine is a field of medicine concerned with the prevention and treatment of injuries and disorders that are related to participation in sports. Clinical assessment in sports medicine can solve many questions about diagnosis, treatment, and prognosis related to health in sports. Physical activity could be defined as any bodily movement produced by skeletal muscles that requires energy expenditure. Physical activity refers to all movement including during leisure time, for transport to get to and from places, or as part of a person’s work. Both moderate- and vigorous-intensity physical activity improve health. Regular physical activity is proven to help prevent and manage noncommunicable diseases such as heart disease, stroke, diabetes, and several cancers. It also helps prevent hypertension, maintain a healthy body weight, and can improve mental health, quality of life, and well-being. Exercise could be defined as a subset of physical activity that is planned, structured, and repetitive and has as a final or an intermediate objective, such as the improvement or maintenance of physical fitness. Gait and posture analysis, clinical assessment, biomechanical analysis, reliability and repeatability research, force platform and electromyography analysis are key in order to improve our knowledge in this area
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    Diagnosis of Lower Genital Tract Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036592978 , 9783036592961
    Language: Undetermined
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Medicine
    Abstract: Lower genital tract diseases include vulvovaginal and HPV-related diseases, ranging from benign to pre-neoplastic and neoplastic lesions. Nowadays, there has been increasing interest in innovative methods to diagnose and prevent cervical cancer through HPV primary screening programs. However, other lower genital tract diseases are unrelated to HPV infection; hence, cytology, colposcopy, and sonography might play a crucial role in assessment and management. This Special Issue aims to address current and emerging issues in the field of the diagnosis, assessment, staging, and management of HPV-related and not-related pathology of the lower female anogenital tract. These may include new advancements in HPV testing and laboratory biomarkers, investigations on the actual role of cytology and implementation of diagnostic tools to implement differential diagnosis, and the current clinical management of lower genital tract diseases
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    Advances in Parvovirus Research 2022 (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594484 , 9783036594491
    Language: Undetermined
    Pages: 1 Online-Ressource (288 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Viruses in the Parvoviridae family constitutes a most diverse and intriguing field of research. Parvoviruses have a long evolutionary history and, beneath an apparent simplicity and uniformity, can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. In addition to interest in the study of basic virology, the translational implications of research on parvoviruses are relevant since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and the inherent complexity in the biology of these apparently simple viruses is an ongoing commitment for the scientific community to address. This Special Issue entitled ‘Advances in Parvovirus Research 2022’ continued the series dedicated to research on viruses belonging to the Parvoviridae family and collected the latest contributions in the field of parvovirus research
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    Recent Advances in Long-Acting Drug Delivery and Formulations (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036594392 , 9783036594385
    Language: Undetermined
    Pages: 1 Online-Ressource (234 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The Special Issue titled “Recent Advances in Long-Acting Drug Delivery and Formulations” encompasses versatile and innovative research domains of oral, ocular, brain, and topical delivery systems and chemical approaches (e.g., prodrugs), highlighting the progress made in identifying excipients (e.g., basic amino acids to ameliorate gastric side effects of non-steroidal anti-inflammatory drugs (NSAIDs)), polymers, and molecular targets to achieve more effective sustained release systems and safer medicine. In this Special Issue, 78 authors have contributed, with eleven original research articles spanning five continents (Asia, Europe, Africa, North America, and Australasia) providing important insights into the pharmaceutical sciences
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    Evidence-Based Diagnosis and Management of Facial Nerve Disorders (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036593906 , 9783036593913
    Language: Undetermined
    Pages: 1 Online-Ressource (148 p.)
    Keywords: Medicine
    Abstract: With increasing speed, new diagnostic and therapeutic approaches for facial nerve disorders are being published. Many of them have improved decision-making, treatment, and the rehabilitation of patients. Unfortunately, there is often a lack of high-quality studies that prove long-term effects or identify subgroups that are of particular benefit. Even a reliable characterization of patients with facial nerve disabilities is often complicated. Therefore, evidence-based management remains challenging. With this Special Issue on the topic of “Evidence-Based Diagnosis and Management of Facial Nerve Disorders”, we have brought together experts from various fields, including speech pathology, plastic surgery, otolaryngology, neurology, and physical therapy, to present the latest developments in relation to facial nerve disorders and to present a great variety of topics to our readership. We can see that the topic of facial nerve palsy offers a vast and dynamic spectrum of developments, and hope that the research presented in this Special Issue shows the importance of a multidisciplinary approach. We hope it will not only enhance our knowledge of this condition, but also ultimately improve patient outcomes and their quality of life to some extent
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    New Insights into Pediatric Pulmonology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036593623 , 9783036593630
    Language: Undetermined
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Medicine
    Abstract: Children with pulmonology issues have always introduced challenges for pediatricians. This Special Issue provides a platform for researchers and clinicians to discuss the novel methods of functional assessment, new insights into exercise physiology, the effect of maturation and puberty on pulmonary parameters, the translational aspects of overweight and obesity, the evaluation of active rehabilitation in pediatric pulmonology, long-term and post-COVID-19 illnesses, the pediatric origin of adult diseases, etc
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    Sudden Cardiac Death: Clinical Updates and Perspectives (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036591988 , 9783036591995
    Language: Undetermined
    Pages: 1 Online-Ressource (218 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: Sudden cardiac death (SCD) affects more than four million patients per year worldwide, and accounts for up to 50% of all cardiovascular deaths. Related to the improved treatment options for cardiovascular diseases during the past several decades (e.g., improved guideline adherence to pharmacotherapies, increasing supply with cardiac devices, and better revascularization strategies), the characteristics of patients presenting with SCD have significantly changed, making risk prediction for SCD even more complex. The present Special Issue reprint addresses the prognostic impact of patients’ characteristics (such as body mass index), airway and ventilation management in patients needing cardiopulmonary resuscitation, and the prognostic value of a targeted ambulance treatment quality improvement programme. Furthermore, the prognostic value of blood-derived biomarkers and cardiac pharmacotherapies for the prevention of SCD was investigated
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    Gene Polymorphism and Nutrition: Relationships with Chronic Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036577708 , 9783036577715
    Language: Undetermined
    Pages: 1 Online-Ressource (152 p.)
    Keywords: Medicine
    Abstract: Studies on global human genomic variation have shown important population-based differences in allele frequencies of common single-nucleotide polymorphisms (SNPs) that influence the expression of genes related to nutrition and, secondarily, chronic disease. Some SNP sites have known functions or associations with diseases or other phenotype characteristics, including nutritional deficiencies and metabolism dietary components. There are many components of human diets that, when combined with the impact of diverse genetics on the metabolism of certain nutrients, have the capacity to give rise to harmful diet–gene interactions. This situation has the potential capacity to modify molecular phenotypes and clinical phenotypes, including human disease. Obesity, diabetes mellitus, chronobiology, osteoporosis, cancer, and many other diseases are fields of potential investigation in this topic area. This Special Issue will include manuscripts that focus on the complex relationship between gene polymorphisms and nutrition across all physiological and chronic diseases
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    Applications of Crystal Engineering in Drug Delivery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036580944 , 9783036580951
    Language: Undetermined
    Pages: 1 Online-Ressource (310 p.)
    Keywords: Medicine ; Pharmacology ; Research & information: general ; Chemistry ; Inorganic chemistry
    Abstract: Crystal engineering is a broad area of research that includes crystal habit modification, polymorphism, solid dispersions, and salt formation. This reprint covers state-of-the-art applications of crystal engineering and includes a combination of research and review articles, with special emphasis on novel drug delivery and targeting applications
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    Personalized Medicine in Ophthalmic Diseases: Challenges and Opportunities (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036580203 , 9783036580210
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine
    Abstract: This reprint focuses on personalized medicine in ophthalmic diseases, their challenges and opportunities, which often involves methods to achieve personalized diagnosis and treatment of ophthalmic diseases. Personalized medicine is a broadly used term to encompass approaches used to tailor healthcare to the needs of individual patients. It has been early adopted in ophthalmology and is mainly achieved through disease stratification and individualization. Therefore, diagnostic techniques that can realize comprehensive individual assessment are very important. Previous studies have put forward techniques such as next-generation sequencing and translational research. Gene therapy-based treatment trials have been presented for ophthalmic diseases such as retinitis pigmentosa and age-related macular degeneration. Recently, with the rapid development of artificial intelligence and interdisciplinary collaboration, concepts such as machine learning and wearable devices have been frequently discussed in ophthalmic research. There might be new promising methods to realize personalized ophthalmology
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    Comparative Pathology and Immunohistochemistry of Veterinary Species (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036579948 , 9783036579955
    Language: Undetermined
    Pages: 1 Online-Ressource (154 p.)
    Keywords: Medicine
    Abstract: Comparative pathology, translational research, and clinical trials involving domestic animals have the ultimate goal of advancing our medical knowledge of both human and veterinary species. Companion, laboratory (from mouse to non-human primates), and wildlife animals play a pivotal role in our understanding of infectious diseases—particularly those with a zoonotic component. This reprint focuses on fundamental and applied research on the comparative pathology and immunohistochemistry of veterinary species. A total of 11 high-quality papers addressing different areas of pathology have been contributed by 62 authors from seven countries, comprising 9 research articles and 2 communications
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    Advanced Research in Pediatric Radiology and Nuclear Medicine (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579597 , 9783036579580
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Advancements in medical imaging modalities have resulted in increasing the importance and demand of pediatric radiology. This reprint showcases various examples of advanced research in pediatric radiology and nuclear medicine. These include the use of medical imaging modalities such as computed tomography, general radiography, magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound for diagnosis, as well as the performance of artificial intelligence (AI) in computer-aided detection and diagnosis in the pediatric population. The radiation dose issue of pediatric radiological examinations and emerging AI technology for dose reduction, as well as the use of three-dimensional printing based on medical images for pediatric surgical planning, healthcare professional education, and patient–clinician communication are also covered
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    Nanoparticles in Ocular Drug Delivery Systems (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036580036 , 9783036580029
    Language: Undetermined
    Pages: 1 Online-Ressource (266 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues, different strategies can be used, namely, the use of viscosifying agents, mucoadhesive polymers, stimuli-responsive polymers, microparticles, and colloidal carriers (e.g., micelles, liposomes, nanosuspensions, nanoemulsions, polymeric, and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations
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    Nuts: Where We Are and Where We Are Going in Research. Proceedings from the NUTS 2022 International Conference (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036578866 , 9783036578873
    Language: Undetermined
    Pages: 1 Online-Ressource (196 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Humans have eaten nuts for thousands of years, yet their consumption was discouraged just a few decades ago due to their high-fat content. This perspective began to change in the early 1990s due to seminal publications from the Adventist Health Study, which showed that nut consumption significantly improved heart health-related outcomes. Many randomized clinical trials, epidemiological studies, and in vitro/in vivo mechanistic studies have since explored the role of eating nuts and its relation to health. Similarly, dried fruits have been scrutinized due to their concentrated sugar content despite their non-sodium micronutrient and fiber density. Due to accumulating evidence on nut and dried fruit intake and health outcomes, an international scientific meeting was organized for leading experts to examine and recapitulate in detail what is well known and established and what avenues of knowledge are still lacking in nut and dried fruit research. These findings highlight the beneficial health potentials of nuts for researchers, health professionals, other stakeholders, and the public while simultaneously pinpointing areas for further investigation to continue informing and guiding health practices and policies
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    Cancer Prevention with Molecular Target Therapies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579276 , 9783036579269
    Language: Undetermined
    Pages: 1 Online-Ressource (208 p.)
    Keywords: Medicine ; Oncology
    Abstract: Personalized medicine plays an important role in cancer prevention. To date, it is clear that many cancers are molecularly distinct subtypes, and different therapeutic approaches would be required for each. Indeed, the identification of cancer susceptibility genes permits identifying patients “at risk” of developing neoplasia and supports modifying individual risk behaviors or the choice of preventive therapy. Additionally, the efficacy of various targeted therapies in different cancer subtypes suggests that treatment choices in the near future will be more and more centered on molecular signatures. Data from preclinical, clinical, and observational studies have revealed the ability to prevent cancer development for compounds with different indications than cancer. The concept of drug repurposing permits combinations that can target several critical pathways of a specific disease, decreasing the risk of resistance observed when using single-agent targeted therapy.This open-access Special Issue brings together original research and review articles on molecular oncology with attention to the early detection and prevention of cancer. It highlights new findings, methods, and technical advances in molecular cancer research. The main feature of this Special Issue is to provide an open-source sharing of significant works in the field of molecular oncology that can increase our understanding of cancer development, which may lead to the discovery of new molecular diagnostic technologies and targeted therapeutics
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    Neonatal Resuscitation with Placental Circulation Intact (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579351 , 9783036579344
    Language: Undetermined
    Pages: 1 Online-Ressource (138 p.)
    Keywords: Medicine
    Abstract: This collection of articles aims to promote the spread of a new way of resuscitating newborns in the delivery room: to perform exactly the same neonatal resuscitation procedures in a different landscape, that is, at mother's side with an intact cord
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    Potentially Toxic Elements Pollution in Urban and Suburban Environments (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036562377 , 9783036562384
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: The importance of studying pollution via potentially toxic elements (PTEs) is becoming a key challenge considering the increasing concern about the presence of PTEs in the environment and their potential impacts on ecosystem functioning and public health due to their persistence and biotoxicity. Regional geochemical research, together with geostatistical computations which are used to identify source patterns of different pollutants related to the underlying geological features and/or anthropogenic activities, is the best approach for characterizing this pollution issue. The collection of research in this Special Issue, “Potentially Toxic Element Pollution in Urban and Suburban Environments”, represents the need of the scientific community to characterize the behavior, transport, fate, and ecotoxicological state of PTEs in environmental matrices in both urban and suburban settings. All the case studies collected are of relevant significance due to their quality, both in the methodologies and the achieved results, and interest to different environmental studies, from China to South Africa to Europe. My role as Guest Editor of this Special Issue was exciting and stimulating. I would like to express my appreciation to all the authors for submitting their original contributions and to the reviewers for their essential role in the process. I would like to thank the editors of Toxics and, in particular, Selena Li for her precious and tireless support
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    Current Challenges and Advances in Cataract Surgery (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036562773 , 9783036562780
    Language: Undetermined
    Pages: 1 Online-Ressource (150 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed
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    Induced Impairment of Neurogenesis and Brain Diseases (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036562148 , 9783036562131
    Language: Undetermined
    Pages: 1 Online-Ressource (282 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders
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    Chronic Fatigue Syndrome/Myalgic Encephalomyelitis : Diagnosis and Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036559698 , 9783036559704
    Language: Undetermined
    Pages: 1 Online-Ressource (276 p.)
    Keywords: Medicine ; Clinical & internal medicine
    Abstract: This Special Issue on CFS/ME collects 18 papers with an interdisciplinary view on the current demographic and epidemiological data and immunological characteristics of CFS/ME and examines the different pathogenic hypotheses, as well as giving information about the latest knowledge on diagnostic investigations, pharmacological, integrative, physical, cognitive-behavioral and psychological curative approaches
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    Biomedical Imaging Technologies for Cardiovascular Disease (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570068 , 9783036570075
    Language: Undetermined
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Medicine ; Cardiovascular medicine
    Abstract: This reprint aims to provide an update on the biomedical imaging technologies that can be used for cardiovascular diseases, including Doppler echocardiography, magnetic resonance imaging and positron emission tomography. Cardiovascular disease imaging assessment includes anatomy, hemodynamics, and tissue biomarkers, which aid the stratification of patient risk and therapy. In addition, this Special Issue includes articles that discuss the recent integration of artificial intelligence and machine learning, in order to support novel approaches to personalized image-based diagnosis
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570419 , 9783036570402
    Language: Undetermined
    Pages: 1 Online-Ressource (212 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy
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    Angiogenesis in Cancers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036569161 , 9783036569178
    Language: Undetermined
    Pages: 1 Online-Ressource (274 p.)
    Keywords: Medicine ; Oncology
    Abstract: Tumor progression is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors. Inflammatory infiltration contributes to tumor progression and metastatic process, and there are many reports of associations between tumor inflammatory infiltration, progression and prognosis. New therapeutic approaches have been developed with the aim to control tumor progression through the targeting of different components of the tumor microenvironment. This reprint will be useful for anyone who wants to learn about cancer: professors and students at universities, scientists at research institutes, biotechnology, and pharmaceutical labs, and lawyers trying to understand the patent literature
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    Novel Anticancer Strategies (Volume II) (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570334 , 9783036570327
    Language: Undetermined
    Pages: 1 Online-Ressource (700 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells
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    Novel Applications and Technologies for the Industrial Exploitation of Algal Derived Marine Bioactives as Nutraceuticals or Pharmaceuticals (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570082 , 9783036570099
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: The active molecules or bioactives (i.e., polysaccharides, fatty acids, proteins, polyphenols, diterpenes, steroids and alkaloids) from algae (seaweed and microalgae) have been widely studied in recent years for multiple pharmaceutical and nutraceutical applications. Innovative and emerging technologies, including but not limited to ultrasounds, microwaves, electric fields, high-pressure supercritical fluids, ionic fluids and plasma, are currently being explored throughout multiple stages of the pre-treatment, extraction, isolation/purification and preservation of biomolecules from algae. This Special Issue will target research papers, reviews, short communications and perspectives on the use of novel technologies for the pre-treatment, extraction, isolation‒purification, characterization and preservation of marine compounds from algae. It will particularly focus on novel research related to algal bioactives with clear and demonstrated industrial applications and focuses
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    Model-Informed Precision Dosing (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036568966 , 9783036568973
    Language: Undetermined
    Pages: 1 Online-Ressource (320 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs
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    Novel Anticancer Strategies (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570310 , 9783036570303
    Language: Undetermined
    Pages: 1 Online-Ressource (396 p.)
    Keywords: Medicine ; Oncology
    Abstract: Novel Anticancer Strategies reviews important findings and updates within the cancer therapy field, of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key features: Nanoparticle-based drug delivery in cancer therapy; Extracellular vesicles for anticancer drug delivery; Peptide-based drug conjugates; Cancer stem cells as a valuable target to eradicate tumor relapse; Spheroids in preclinical model for cancer research; and cancer immunotherapy
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    Tryptophan in Nutrition and Health (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036570778 , 9783036570761
    Language: Undetermined
    Pages: 1 Online-Ressource (324 p.)
    Keywords: Medicine ; Pharmacology
    Abstract: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society
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    A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036569185 , 9783036569192
    Language: Undetermined
    Pages: 1 Online-Ressource (414 p.)
    Keywords: Medicine ; Physiology
    Abstract: This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene regulation. The key physiological functions of vitamin D are the regulation of calcium homeostasis, which is essential for bone mineralization, and the modulation of the immune system by stimulating innate immunity and preventing overreactions of adaptive immunity. This reprint presents recent developments and the latest research in the fascinating broad range of today’s vitamin D biology, from evolution to systems biology
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    Advanced Research on Animal Venoms in China (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
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    ISBN: 9783036574349 , 9783036574356
    Language: Undetermined
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Medical toxicology
    Abstract: Recently, Chinese researchers have made significant progress in animal venom research in comprehending the diversity and complexity of these molecules and their potential applications in medicine, biotechnology, and as research tools. Advancements in 'omics' technologies such as proteomics, genomics, and transcriptomics have empowered Chinese researchers to identify and analyze venom-coded genes and proteins, revealing a kaleidoscope of novel peptide toxins with diverse functions and activities. The reprint focus on the perspective on some of the most recent and dynamic contributions of animal toxins research by Chinese researchers. The purpose of this reprint is to provide the latest work by Chinese researchers on the discovery of animal toxins, the mechanism underlining their actions, the mining of drug leads from peptide toxins, and the diagnosis and treatment of bites or stings by venomous animals
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    Dietary Intake and Chronic Disease Prevention (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036573090 , 9783036573083
    Language: Undetermined
    Pages: 1 Online-Ressource (292 p.)
    Keywords: Medicine
    Abstract: This reprint describes how lifestyle changes can impact the incidence and progression of chronic non-communicable diseases. In this context, regular physical activity and heathy nutritional habits are very important. Moreover, natural bioactive compounds could represent a new adjuvant therapy in the clinical management of these pathological conditions
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    Strategies to Enhance Drug Permeability across Biological Barriers (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574639 , 9783036574622
    Language: Undetermined
    Pages: 1 Online-Ressource (278 p.)
    Keywords: Medicine ; Pharmaceutical industries
    Abstract: Overcoming biological barriers is a significant challenge in drug development, and recent advancements in drug delivery systems and technologies offer promising solutions. This Special Issue highlights the innovative approaches and techniques being used to improve drug permeability and absorption, as well as their potential impact on a wide range of therapeutic goals. These advancements being made in drug delivery and permeability offer exciting possibilities to improve patient outcomes
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    Neuroscience, Neurophysiology and Symmetry (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574783 , 9783036574790
    Language: Undetermined
    Pages: 1 Online-Ressource (90 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: This reprint focuses on fundamental and applied research on asymmetry of movement and postural balance and underlying functions in humans. Experimental protocols based on kinetic, kinematic, radiological, functional magnetic resonance imaging and transcranial Doppler ultrasound data taken from healthy, young, elderly and pathological individuals provide new insights into asymmetry in human movement and posture and are presented in the Special Issue
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    Recent Advances in Psychopathology in Neurodevelopmental Disorders: From Bench to Bedside (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036574141 , 9783036574158
    Language: Undetermined
    Pages: 1 Online-Ressource (178 p.)
    Keywords: Medicine ; Neurosciences
    Abstract: Psychopathology, including functional psychiatric disorders, such as schizophrenia, bipolar disorder, major depressive disorder and anxiety disorders, and also dementia and challenging behaviour, is common in people with neurodevelopmental disorders (NDDs), such as intellectual and developmental disabilities (IDD), autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), and is the cause for a major public health concern. Much research has been conducted in the last three decades to understand this issue and develop effective interventions. Still, a lot remains unknown, for which high-quality translational research is urgently needed. In this Special Issue, we drew together research on recent advances addressing these issues. The areas covered included life expectancy among people with and without intellectual disabilities, the social and emotional development of people with intellectual disabilities and ASD, the influence of external environmental factors in determining aggressive behaviour in people with intellectual disabilities, parent and child training for children with autism and intellectual disabilities, how the presence of deafness influences quality of life, the views of prescribers on the deprescribing of antipsychotics among adults with intellectual disabilities, the views of people with intellectual disabilities who took part in the deprescribing, the views of direct-care workers on the causes of challenging behaviours in people with intellectual disabilities, and the validation of tools to detect cognitive decline in adults with intellectual disabilities
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    Antimicrobial Prescribing and Stewardship, 1st Volume (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572550 , 9783036572543
    Language: Undetermined
    Pages: 1 Online-Ressource (372 p.)
    Keywords: Medicine
    Abstract: This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship;Diagnostic stewardship;Influence of antimicrobial utilisation changes in antimicrobial resistance;Impact of antimicrobial stewardship on quality performance measures and patient outcomes;Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers;Behavioural change approaches to antimicrobial stewardship;Collaborative practice agreements in antimicrobial stewardship;Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology);Tackling AMR through antimicrobial stewardship in low- and middle-income countries;Antimicrobial stewardship for animal health;Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals);Antimicrobial use and stewardship in the context of the COVID-19 pandemic;Global collaborations to tackle AMR through antimicrobial stewardship
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    Carbazole Derivatives: Latest Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036572888 , 9783036572895
    Language: Undetermined
    Pages: 1 Online-Ressource (98 p.)
    Keywords: Medicine
    Abstract: Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, “Carbazole derivatives: latest progress and prospects”, recent studies on carbazole derivatives that are utilized, such as β1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported
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    Biological and Pharmacological Activity of Plant Natural Compounds III (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036570617 , 9783036570600
    Language: Undetermined
    Pages: 1 Online-Ressource (304 p.)
    Keywords: Medicine
    Abstract: By joining the two previous editions, this Special Issue completes the trilogy of Special Issues entitled "Biological and Pharmacological Activity of Plant Natural Compounds", which deal with the properties and effects of phytonatural products in preclinical models. This third edition has also remained focused on their therapeutic potential, with the aim of increasing and contributing to the expansion of our scientific knowledge on plants in human health. We hope readers will enjoy this Special Issue as much as the previous publications
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    Application of Nanomedicine in Immunotherapy: Recent Advances and Prospects (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036582405 , 9783036582412
    Language: Undetermined
    Pages: 1 Online-Ressource (220 p.)
    Keywords: Medicine
    Abstract: Nanomedicine is a special medical field focused on the application of nanotechnology to provide innovations for healthcare in different areas, including the treatment of a wide variety of diseases, including cancer, infections, and auto-immune disorders. The field emerged during the 1980s, aligning with the approval of the first regulatory-agency-approved nanomedical oncological drugs. Additionally, nanotechnology has played a pivotal role in the development of mRNA vaccines utilized during the COVID-19 pandemic, further establishing its enduring significance in the domains of science and biomedical innovation. The reasons for the use of nanotechnology in biomedicine can vary but are mostly the protection and/or delivery of bioactive molecules to target tissues. The general idea is to create nanoscopic platforms that can interact differently with biological systems, either through pharmacokinetic modifications or through the preferential activation of some biological pathway. The intricate biomolecular interactions that underlie the functioning of the biological system take place within the nanoscale. So, nanoparticles can be designed to be similar in size to key biological structures like large biomolecules or small organelles, enabling them to interact with biological systems in unique ways, which can improve the effects of drugs used in the treatment of certain diseases. In other words, highly distinct and improved biological effects can emerge from such interactions
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    Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036583839 , 9783036583822
    Language: Undetermined
    Pages: 1 Online-Ressource (400 p.)
    Keywords: Medicine ; Oncology
    Abstract: This reprint contains five original research papers and eight review articles for the Special Issue "Molecular Mechanisms Underlying Cancer Prevention and Intervention with Bioactive Food Components" which is guest edited by Prof. Dr. Anupam Bishayee. There is one item that indicated the correction of one review
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    Respiratory Disease in the COVID-19 Era (2023)
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    Details
    ISBN: 9783036579160 , 9783036579177
    Language: Undetermined
    Pages: 1 Online-Ressource (112 p.)
    Keywords: Medicine ; Epidemiology & medical statistics
    Abstract: Coronavirus disease 2019 (COVID-19) is a new respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused a global pandemic. COVID-19 patients often develop acute respiratory distress syndrome (ARDS), which involves acute and lethal respiratory failure. In a meta-analysis, the median incidence of ARDS in COVID-19 patients was found to be 35 (2-79)%, while the mortality rate in COVID-19-associated ARDS patients was found to be 39 (12.5-73.1)% (Hasan, et al. Expert Rev Repoir Med. 2020; 14: 1149). As of 12 December 2021, 270,373,764 cases had been confirmed as COVID-19 and 5,321,321 cases had resulted in death, according to the World Health Organization webpage. Various symptoms such as persistent fatigue, myalgia, and insomnia can persist after recovery from COVID-19; these symptoms are called “long COVID-19”. Patients with COVID-19 who survive but develop pulmonary fibrosis may experience persistent dyspnea upon exertion, a decrease in pulmonary function, and/or a radiological abnormal shadow. Antifibrotic drugs including nintedanib and pirfenidone are candidate drugs for the treatment of pulmonary fibrosis due to COVID-19; randomized controlled trials are ongoing. However, there are limited studies about respiratory disease caused by COVID-19. Given the clinical significance of this topic and its impact on clinical practice and public health, Medicina have published a Special Issue entitled “Respiratory Disease in the COVID-19 Era” with the aim of gathering accurate and up-to-date scientific information of this topic
    Note: English
    URL: kostenfrei
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