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  • 1
    Online Resource
    Online Resource
    Cell Culture : Advanced Technology and Applications in Medical and Life Sciences (2022)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839694462 , 9781839694455 , 9781839694479
    Language: Undetermined
    Pages: 1 Online-Ressource (154 p.)
    Series Statement: Biochemistry 30
    Keywords: Cellular biology (cytology)
    Abstract: Cell culture is cell cloning technology that simulates in vivo environment conditions such as asepsis, appropriate temperature, and pH as well as certain nutritional conditions to enable cells to survive, grow, reproduce, and maintain their structure and function. Cell culture can be used to grow human, animal, plant, and microbial cells. Each type of cell culture has its own characteristics and essential conditions. This book focuses on the advanced technology and applications of cell culture in the research and practice of medical and life sciences. Chapters address such topics as primary cancer cell cultures, 2D and 3D cell cultures, stem cells, nanotechnology, and more
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 2
    Online Resource
    Online Resource
    Proteoforms : Concept and Applications in Medical Sciences (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838800345 , 9781838800338 , 9781839628320
    Language: English
    Pages: 1 Online-Ressource (90 p.)
    Keywords: Proteins
    Abstract: A proteoform is the basic unit in a proteome, defined as its amino acid sequence + post-translational modifications + spatial conformation + localization + cofactors + binding partners + a function, which is the final functional performer of a gene. Studies on proteoforms offer in-depth insights and can lead to the discovery of reliable biomarkers and therapeutic targets for effective prediction, diagnosis, prognostic assessment, and therapy of disease. This book focuses on the concept, study, and applications of proteoforms. Chapters cover such topics as methodologies for identifying and preparing proteoforms, proteoform pattern alteration in pituitary adenomas, and proteoforms in leukemia
    Note: English
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
  • 3
    Online Resource
    Online Resource
    Ubiquitin : Proteasome Pathway (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781838808419 , 9781838804329 , 9781838808426
    Language: English
    Pages: 1 Online-Ressource (124 p.)
    Series Statement: Biochemistry 18
    Keywords: Proteins
    Abstract: The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 4
    Online Resource
    Online Resource
    Metabolomics : Methodology and Applications in Medical Sciences and Life Sciences (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839690846 , 9781839690839 , 9781839690853
    Language: Undetermined
    Pages: 1 Online-Ressource (168 p.)
    Keywords: Biochemistry
    Abstract: Metabolomics is the methodology and theory to study the metabolome, including targeted approaches based on selected/multiple reaction monitoring (SRM/MRM) and untargeted approaches based on nuclear magnetic resonance (NMR) or mass spectrometry (MS). The metabolome contains all metabolites derived from sugars, lipids, proteins, and nucleic acids in a given biological system, tissue, cell, or body fluid in a metabolic network system. Metabolomic variations directly link to molecular mechanisms of a disease, reliable therapeutic targets, and effective biomarkers for prediction, diagnosis, and prognostic assessment of disease. This book presents new advances in the concept and methodology of metabolomics, as well as applications of metabolomics in the research and practice of medical and life sciences
    Note: English
    URL: kostenfrei
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
  • 5
    Online Resource
    Online Resource
    Molecular network study of pituitary adenomas (2020)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    ISBN: 9782889636020
    Language: English
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Medicine ; Endocrinology
    Abstract: Pituitary adenomas are a category of neoplasms with a high degree of heterogeneity that occur in the central regulatory organ pituitary, which plays important roles in the hypothalamus–pituitary-targeted organ axis systems that impact on important physiological functions of human body. Rapidly developed multi-omics and systems biology are impacting on treatment of pituitary adenomas and changing the paradigms from the traditional single-factor strategy to a multi-parameter systematic strategy. A series of molecular alterations at different levels of genes (genome), RNAs (transcriptome), proteins (proteome), peptides (peptidome), metabolites (metabolome), and imaging characteristics (radiome) that resulted from exogenous and endogenous carcinogens are involved in pituitary tumorigenesis and mutually associate and function in a molecular network system, thus determines the difficulty in the use of a single molecule as biomarker to clarify its molecular mechanisms, and to predict, prevent, diagnose, and treat a pituitary adenoma. Of them, molecular network study plays central roles. A key molecule-panel biomarker that is derived from molecular network is necessary for accurately clinical practice of a pituitary adenoma. The modern multi-omics, computation biology, and systems biology technologies lead to the possibility in recognizing really reliable molecular-panel biomarker for research and clinical practice in pituitary adenomas
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 6
    Online Resource
    Online Resource
    Modifications in Biomacromolecules (2024)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781803559971 , 9781803559964 , 9781803559988
    Language: Undetermined
    Pages: 1 Online-Ressource (170 p.)
    Series Statement: Biochemistry 51
    Keywords: Molecular biology
    Abstract: Modifications in biomacromolecules (DNA, RNA, and proteins) are important molecular events in different pathophysiological conditions. These modifications include DNA modifications, RNA post-transcriptional modifications, and protein post-translational modifications that regulate the structures and functions of biomacromolecules and even the entire biological system. In addition, they are associated with a wide spectrum of diseases. Biomacromolecular modifications are important factors in creating proteoforms that constitute the end-point structural and functional forms of a gene or protein that can be applied for predictive, preventive, and personalized medicine (PPPM) as well as precision medicine (PM)
    Note: English
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
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