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  • 1
    Article
    Article
    Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae) (2015)
    Show associated volumes/articles
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 166 (2015), p. 279-285
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 166 (2015), p. 279-285
    DDC: 610
    Abstract: Field investigations highlighted the use of Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh), a small tree used by the Wayana Amerindians in Twenke-Taluhwen and Antecume-Pata, French Guiana, for the treatment of malaria, and administered either orally in the form of a decoction or applied externally over the whole body. This use appears limited to the Wayana cultural group in French Guiana and has never been reported anywhere else. Our goal was to evaluate the antimalarial and anti-inflammatory activities of a P. acutangulum decoction to explain the good reputation of this remedy. Interviews with the Wayana inhabitants of Twenke-Taluhwen and Antecume-Pata were conducted within the TRAMAZ project according to the TRAMIL methodology, which is based on a quantitative and qualitative analysis of medicinal plant uses. A decoction of dried aerial parts of P. acutangulum was prepared in consistency with the Wayana recipe. In vitro antiplasmodial assays were performed on chloroquine-resistant FcB1 ([(3)H]-hypoxanthine bioassay) and 7G8 (pLDH bioassay) P. falciparum strains and on chloroquine sensitive NF54 ([(3)H]-hypoxanthine bioassay) P. falciparum strain. In vitro anti-inflammatory activity (IL-1β, IL-6, IL-8, TNFα) was evaluated on LPS-stimulated human PBMC and NO secretion inhibition was measured on LPS stimulated RAW murine macrophages. Cytotoxicity of the decoction was measured on L6 mammalian cells, PBMCs, and RAW cells. A preliminary evaluation of the in vivo antimalarial activity of the decoction, administered orally twice daily, was assessed by the classical four-day suppressive test against P. berghei NK65 in mice. The decoction displayed a good antiplasmodial activity in vitro against the three tested strains, regardless to the bioassay used, with IC50 values of 3.3µg/mL and 10.3µg/mL against P. falciparum FcB1 and NF54, respectively and 19.0µg/mL against P. falciparum 7G8. It also exhibited significant anti-inflammatory activity in vitro in a dose dependent manner. At a concentration of 50µg/mL, the decoction inhibited the secretion of the following pro-inflammatory cytokines: TNFα (-18%), IL-1β (-58%), IL-6 (-32%), IL-8 (-21%). It also exhibited a mild NO secretion inhibition (-13%) at the same concentration. The decoction was non-cytotoxic against L6 cells (IC50〉100µg/mL), RAW cells and PBMC. In vivo, 150µL of the decoction given orally twice a day (equivalent to 350mg/kg/day of dried extract) inhibited 39.7% average parasite growth, with more than 50% of inhibition in three mice over five. The absence of response for the two remaining mice, however, induced a strong standard deviation. This study highlighted the in vitro antiplasmodial activity of the decoction of P. acutangulum aerial parts, used by Wayana Amerindians from the Upper-Maroni in French Guiana in case of malaria. Its antioxidant and anti-inflammatory potential, which may help to explain its use against this disease, was demonstrated using models of artificially stimulated cells.
    Note: Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    DOI: 10.1016/j.jep.2015.03.015
    URL: Volltext
    URL: http://www.ncbi.nlm.nih.gov/pubmed/25792015
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  • 2
    Article
    Article
    Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians (2016)
    Show associated volumes/articles
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs (2016)
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: (2016)
    DDC: 610
    DOI: 10.1016/j.jep.2016.04.053
    URL: Volltext
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    OLC Ethnologie
  • 3
    Article
    Article
    Antimalarial plants used by indigenous people of the Upper Rio Negro in Amazonas, Brazil (2016)
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    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 178 (2016), p. 188-198
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 178 (2016), p. 188-198
    DDC: 610
    Abstract: This is the first intercultural report of antimalarial plants in this region. The aim of this study was to document the medicinal plants used against malaria by indigenous people in the Upper Rio Negro region and to review the literature on antimalarial activity and traditional use of the cited species. Participant observation, semi-structured interviews, and ethnobotanical walks were conducted with 89 informants in five indigenous communities between April 2010 and November 2013 to obtain information on the use of medicinal plants against malaria. We reviewed academic databases for papers published in scientific journals up to January 2014 in order to find works on ethnopharmacology, ethnobotany, and antimalarial activity of the species cited. Forty-six plant species belonging to 24 families are mentioned. Fabaceae (17.4%), Arecaceae (13.0%) and Euphorbiaceae (6.5%) account together for 36.9% of these species. Only seven plant species showed a relatively high consensus. Among the plant parts, barks (34.0%) and roots (28.0%) were the most widely used. Of the 46 species cited, 18 (39.1%) have already been studied for their antimalarial properties according to the literature, and 26 species (56.5%) have no laboratory essays on antimalarial activity. Local traditional knowledge of the use of antimalarials is still widespread in indigenous communities of the Upper Rio Negro, where 46 plants species used against malaria were recorded. Our studies highlight promising new plants for future studies: Glycidendron amazonicum, Heteropsis tenuispadix, Monopteryx uaucu, Phenakospermum guianensis, Pouteria ucuqui, Sagotia brachysepala and notably Aspidosperma schultesii, Ampelozizyphus amazonicus, Euterpe catinga, E. precatoria, Physalis angulata, Cocos nucifera and Swartzia argentea with high-use consensus. Experimental validation of these remedies may help in developing new drugs for malaria.
    Note: Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    DOI: 10.1016/j.jep.2015.11.048
    URL: Volltext
    URL: http://www.ncbi.nlm.nih.gov/pubmed/26656535
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  • 4
    Article
    Article
    Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians (2016)
    Show associated volumes/articles
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 187 (2016), p. 241-248
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 187 (2016), p. 241-248
    DDC: 610
    Abstract: Psidium acutangulum Mart. ex DC is a small tree used by the Wayana Amerindians from the Upper-Maroni in French Guiana for the treatment of malaria. In a previous study, we highlighted the in vitro antiplasmodial, antioxidant and anti-inflammatory potential of the traditional decoction of P. acutangulum aerial parts. Our goal was then to investigate on the origin of the biological activity of the traditional remedy, and eventually characterize active constituents. Liquid-liquid extractions were performed on the decoction, and the antiplasmodial activity evaluated against chloroquine-resistant FcB1 ([(3)H]-hypoxanthine bioassay) and 7G8 (pLDH bioassay) P. falciparum strains, and on a chloroquine sensitive NF54 ([(3)H]-hypoxanthine bioassay) P. falciparum strain. The ethyl acetate fraction (D) was active and underwent bioguided fractionation. All the isolated compounds were tested on P. falciparum FcB1 strain. In vitro anti-inflammatory activity (IL-1β, IL-6, IL-8, TNFα) of the ethyl acetate fraction and of an anti-Plasmodium active compound, was concurrently assessed on LPS-stimulated human PBMC and NO secretion inhibition was measured on LPS stimulated RAW murine macrophages. Cytotoxicity of the fractions and pure compounds was measured on VERO cells, L6 mammalian cells, PBMCs, and RAW cells. Fractionation of the ethyl acetate soluble fraction (IC50 ranging from 3.4 to 〈1µg/mL depending on the parasite strain) led to the isolation of six pure compounds: catechin and five glycosylated quercetin derivatives. These compounds have never been isolated from this plant species. Two of these compounds (wayanin and guaijaverin) were found to be moderately active against P. falciparum FcB1 in vitro (IC50 5.5 and 6.9µM respectively). We proposed the name wayanin during public meetings organized in June 2015 in the Upper-Maroni villages, in homage to the medicinal knowledge of the Wayana population. At 50µg/mL, the ethyl acetate fraction (D) significantly inhibited IL-1β secretion (-46%) and NO production (-21%), as previously observed for the decoction. The effects of D and guiajaverin (4) on the secretion of other cytokines or NO production were not significant. The confirmed antiplasmodial activity of the ethyl acetate soluble fraction of the decoction and of the isolated compounds support the previous results obtained on the P. acutangulum decoction. The antiplasmodial activity might be due to a mixture of moderately active non-toxic flavonoids. The anti-inflammatory activities were less marked for ethyl acetate fraction (D) than for the decoction.
    Note: Copyright: © Elsevier Ireland Ltd , Copyright: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
    DOI: 10.1016/j.jep.2016.04.053
    URL: Volltext
    URL: http://www.sciencedirect.com/science/article/pii/S0378874116302537
    URL: http://www.ncbi.nlm.nih.gov/pubmed/27132714
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  • 5
    Article
    Article
    Treating leishmaniasis in Amazonia: A review of ethnomedicinal concepts and pharmaco-chemical analysis of traditional treatments to inspire modern phytotherapies (2017)
    Show associated volumes/articles
    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 199 (2017), p. 211-230
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 199 (2017), p. 211-230
    DDC: 610
    DOI: 10.1016/j.jep.2017.01.048
    URL: Volltext
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  • 6
    Article
    Article
    Treatment of leishmaniasis in the Oyapock basin (French Guiana): A K.A.P. survey and analysis of the evolution of phytotherapy knowledge amongst Wayãpi Indians (2011)
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    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 137, No. 3 (2011), p. 1228-1240
    Details
    ISSN: 0378-8741
    Language: Undetermined
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 137, No. 3 (2011), p. 1228-1240
    DDC: 610
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    OLC Ethnologie
  • 7
    Article
    Article
    Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon) (2013)
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    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 146, No. 1 (2013), p. 127-153
    Details
    ISSN: 0378-8741
    Language: Undetermined
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 146, No. 1 (2013), p. 127-153
    DDC: 610
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  • 8
    Book
    Book
    Methods in historical ecology : insights from Amazonia (2021)
    Abingdon, Oxon : Routledge
    Details
    ISBN: 9780367182205 , 9780367182212
    Language: English
    Pages: 185 Seiten , Illustrationen, Karten
    Parallel Title: Erscheint auch als Methods in historical ecology
    DDC: 304.20981/1
    Keywords: Human ecology History ; Ecology Methodology ; Aufsatzsammlung ; Amazonas-Gebiet ; Historische Ökologie ; Archäologie
    Abstract: Foreword / by Clark L. Erickson -- Archaeology of invisible landscapes / Stéphen Rostain -- Pedological perspective : concepts and facts / Michel Brossard and Jeanne Brancier -- Soil micromorphology / Jeanne Brancier and Cécilia Cammas -- Physicochemical analysis of neotropical soils / Jeanne Brancier, Amandine Courte, Dominique Todisco and Michel Brossard -- Magnetic properties of soils / François Lévêque -- Geomagnetic survey / François Lévêque -- Pedestrian archaeological surveys in Neotropical rainforests / Mickael Mestre and Martijn Van Den Bel -- Detecting ditched sites on LiDAR-generated digital elevation models : from technical specifications to interpretation keys / Mickaël Mestre, Grégoire Vincent, Caroline Bedeau, Nina Antonoff, Olivier Brunaux, Pierre Gautreau and Matthieu Noucher -- Phytoliths : a tool for Neotropical historical ecology, with focus on bamboodominated forests / Laurent Bremond and Charly Favier -- Anthracology in the tropics : how wood charcoals help us to better understand today ecosystems / Stéphanie Bodin, Julie Morin-Rivat, Laurent Bremond, Rita Scheel-Ybert, Christophe Tardy and Christophe Vaschalde -- Forest trees inventories / Jean-François Molino, William Balée, Julien Engel, Claire Martin and Daniel Sabatier -- Historical genomics / Louise Brousseau, Pauline Garnier-Gere and Charles R. Clement -- Landscape-scale study of soil communities / Nina Gazal, Antoine Brin, Sophie Manzi, Emeline Houël, Emmanuel Lapied, Thibaud Decaëns and Mélanie Roy -- The multiple roles of soil animals in the interpretation of archaeological soils and sediments in lowland tropical South America / Doyle Mckey, Delphine Renard and Rumsaïs Blatrix -- History and ethnohistory of ancient settlements / Pierre Grenand and Damien Davy -- Ethnoecology of landscape uses and interpretations / Damien Davy, Pierre Grenand and Guillaume Odonne -- From single species to multiethnic ethnobotanical databases to understand past land use / Guillaume Odonne, Damien Davy and Pierre Grenand -- Historical ecology as an instrument in defence of forest peoples : reflections from the Tapajós River, Brazil / Bruna Cigaran Da Rocha and Vinicius Eduardo Honorato De Oliveira -- Applied historical ecology / William Balée and Meredith Dudley -- Conclusion. Historical ecology : challenges and perspectives in a changing world / Chelsey Geralda Armstrong and andré Braga Junqueira.
    Abstract: "This book presents some of the most recent tools, methods and concepts in historical ecology. It introduces students and researchers to state of the art techniques and showcases a wide array of methods dedicated to understanding the history of tropical landscapes. The chapters cover the detection and characterization of archaeological features, living organisms as witnesses of past human activities, ethno-ecological knowledge of ancient anthropogenic landscapes, and societal impacts of historical ecology. Whilst mainly based on Amazonian experiences, the contributions aim to strengthen synergies between disciplines and to propose solutions that can be applied elsewhere in the field"--
    Note: Includes bibliographical references and index
    URL: Inhaltsverzeichnis
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    GBV
  • 9
    Online Resource
    Online Resource
    Climatic and Ecological Change in the Americas : A Perspective from Historical Ecology (2024)
    [Erscheinungsort nicht ermittelbar] : Taylor & Francis
    Details
    ISBN: 9781003316497 , 9781032327433 , 9781032321073
    Language: Undetermined
    Pages: 1 Online-Ressource (257 p.)
    Series Statement: New Frontiers in Historical Ecology
    Keywords: Anthropology
    Abstract: This book offers a comparative analysis of the experiences, responses, and adaptations of people to climate variability and environmental change across the Americas. It foregrounds historical ecology as a structural framework for understanding the climate change crisis throughout the region and throughout time. In recent years, Indigenous and local populations in particular have experienced climate change effects such as altered weather patterns, seasonal irregularities, flooding and drought, and difficulties relating to subsistence practices. Understanding and dealing with these challenges has drawn on peoples’ longstanding experience with climate variability and in some cases includes models of mitigation and responses that are millennia old. With contributions from specialists across the Americas, this volume will be of interest to scholars from fields including anthropology, archaeology, geography, environmental studies, and Indigenous studies
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 10
    Online Resource
    Online Resource
    Climatic and ecological change in the Americas : a perspective from historical ecology (2024)
    London : New York
    Details
    ISBN: 9781003316497
    Language: English
    Pages: 1 Online-Ressource (volumes cm)
    Series Statement: New frontiers in historical ecology
    Parallel Title: Erscheint auch als Climatic and ecological change in the Americas
    DDC: 909/.04
    Keywords: Ethnohistory Comparative method ; Climatic changes
    Abstract: "This book offers a comparative analysis of the experiences, responses, and adaptations of people to climate variability and environmental change across the Americas. It foregrounds historical ecology as a structural framework for understanding the climate change crisis throughout the region and throughout time. In recent years Indigenous and local populations in particular have experienced climate change effects such as altered weather patterns, seasonal irregularities, flooding and drought, and difficulties relating to subsistence practices. Understanding and dealing with these challenges has drawn on peoples' longstanding experience with climate variability and in some cases includes models of mitigation and responses that are millennia old. With contributions from specialists across the Americas, the volume will be of interest to scholars from fields including anthropology, archaeology, geography, environmental studies, and Indigenous studies"--
    Description / Table of Contents: Introduction -- "Open the Floodgates of Heaven": Amazonian Climate Change in Pre-Columbian Times -- The Milpa Cycle as a Sustainable Ecological Resource -- Confronting Climatic Instability in Coastal California Through the Lens of Archaeology and Historical Ecology -- Indigenous People Prevented Climate-Induced Ecological Change for Millennia: Evidence from the Prairie Peninsula and Fire-Loving Forests of Eastern North America -- Indigenous Land Use and Fire Resilience of Southwest USA Ponderosa Pine Forests -- Different Relational Models have Shaped the Biocultural Conservation over Time of Araucaria araucana Forests and Their People -- Ancient and Ongoing Land-Use as Climate Change Mitigation in Ts'msyen, Heiltsuk, and Wuikinuxv Homelands -- Clam Gardens Across Generations and Places Support Social-Ecological Resilience to Global Change -- Ancient Knowledge, Future Wisdom: Archaeological Perspectives of Caribbean Coastal Food and Habitat Security during Times of Climate Crises -- Whose Climate Change Is It? A Thousand-Year Example of Kali'na Responses to Shifting Coastal Landscapes in the Lower Maroni River -- Long-Term Ecological and Climate Changes through Amazonian Indigenous Oral Histories -- Owning Climate Change among the Makushi and Akawaio -- Postface.
    Note: Includes bibliographical references and index
    URL: kostenfrei
    URL: kostenfrei
    URL: kostenfrei
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    MPI Ethno. Forsch.
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