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  • 1
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789533079974 , 9789535167877
    Language: English
    Pages: 1 Online-Ressource (140 p.)
    Keywords: Vascular surgery
    Abstract: Accompanied by the advent of animal cloning, the technique of nuclear transfer produced alpha1,3-galactosyltransferase-knockout (Gal-KO) pigs in many institutes, including the ones in Japan, at the beginning of 21st Century. In addition, the controversy of the risks of PERV has gradually minimized, because of the fact that there are no cases of PERV infections reported in humans. Furthermore, a large clinical wave for islet allotransplantation resumed the interest of xenotransplantation, especially porcine islet transplantation and some exceptions. Clinical trials were done in many countries so far, such as Sweden, China, Mexico, USA (Inventory of Human Xenotransplantation Practices - IXA and HUG in collaboration with WHO). In addition, a new clinical trial was approved by the government, and resumed the porcine islet transplantation research in New Zealand two years ago
    Note: English
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  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9789535133568 , 9789535133551 , 9789535147411
    Language: Undetermined
    Pages: 1 Online-Ressource (192 p.)
    Keywords: Biomedical engineering
    Abstract: It has been nearly 5 years since I edited the last version. In this version, the focus is on islet transplantation. In addition, interesting topics dealing with corneal and peripheral nerve transplantation and decellularization are covered. Unfortunately, clinical trials have not started in Japan, the USA, or Europe in the past 5 years. On the other hand, clinical trials were completed in many countries and so on (inventory of human xenotransplantation practices: IXA and HUG in collaboration with the WHO). In addition, in Japan, clinical trials related to cell transplantation have been initiated, and guidelines for xenotransplantation have been revised. In the near future, some clinical trials on xenotransplantation using genetically modified pigs or the microencapsulation of pancreatic islets will start
    Note: English
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  • 3
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    ISBN: 9781789856644 , 9781789856637 , 9781789845211
    Language: English
    Pages: 1 Online-Ressource (156 p.)
    Keywords: Biomedical engineering
    Abstract: Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells
    Note: English
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