ISBN:
9788864535654
,
9788864535647
,
9788892731684
Language:
Undetermined
Pages:
1 Online-Ressource (80 p.)
Series Statement:
Premio Tesi di Dottorato
Keywords:
Pre-clinical medicine: basic sciences
;
Pharmacy / dispensing
;
Biology, life sciences
;
Biochemistry
;
Molecular biology
Abstract:
A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhibitors, alone and in combination with mTOR, with a dual mTOR/PI3K inhibitor and with a pan PI3K inhibitor in in-vitro and in-vivo MPN models. Our findings of strong synergy between the JAK2 inhibitors and mTOR/PI3K inhibitor suggested that we might be able to administer these drugs at lower concentrations than when the drugs are used individually. This provides a framework for combination trials using compounds in patients with myeloproliferative neoplasms
Note:
English
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