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  • 1
    Online Resource
    Online Resource
    Cells of the Immune System (2020)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789855845 , 9781789855838 , 9781838804305
    Language: English
    Pages: 1 Online-Ressource (246 p.)
    Keywords: Immunology
    Abstract: The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness
    Note: English
    URL: kostenfrei
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    MPI Ethno. Forsch.
  • 2
    Online Resource
    Online Resource
    Myelodysplastic Syndromes (2016)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9789535125877 , 9789535125860 , 9789535172963
    Language: English
    Pages: 1 Online-Ressource (210 p.)
    Keywords: Pathology
    Abstract: This book is a comprehensive overview of myelodysplastic syndromes (MDS). MDS are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral cytopenias, frequent karyotypic abnormalities, and risk of transformation to acute myeloid leukemia (AML). Median age of patients with MDS is about 70 years. Various immune abnormalities occur in MDS patients, and the relationship between autoimmune disorders and MDS is described. Accurate prognostication and risk stratification for individual patients with MDS are important for clinical treatment decisions. Patients with MDS are classified into two broad prognostic categories: lower risk and higher risk. The approval of lenalidomide, azacitidine, and decitabine in last 10 years helped to diminish the clinical impact of MDS and delayed its progression to AML
    Note: English
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
  • 3
    Online Resource
    Online Resource
    Multiple Myeloma (2021)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781839686214 , 9781839686207 , 9781839686221
    Language: English
    Pages: 1 Online-Ressource (126 p.)
    Keywords: Oncology
    Abstract: This book deals with the diagnosis and treatment of multiple myeloma. Multiple myeloma is a plasma cell disorder, the prognosis of which has dramatically improved in the last years thanks to new immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies, in relapsed/refractory disease and a diagnosis. Chapters cover such topics as prognostic and predictive factors in newly diagnosed multiple myeloma, treatment approaches, antibody therapies, and three-dimensional (3D) models mimicking multiple myeloma bone marrow-microenvironment interactions
    Note: English
    URL: kostenfrei
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
  • 4
    Online Resource
    Online Resource
    Recent Developments in Myelodysplastic Syndromes (2019)
    [Erscheinungsort nicht ermittelbar] : IntechOpen
    Details
    ISBN: 9781789854787 , 9781789854770 , 9781839620409
    Language: Undetermined
    Pages: 1 Online-Ressource (120 p.)
    Keywords: Oncology
    Abstract: This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit
    Note: English
    URL: kostenfrei
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    Online Resource
    MPI Ethno. Forsch.
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