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  • 1
    Article
    Article
    Medicinal plants and finished marketed herbal products used in the treatment of malaria in the Ashanti region, Ghana (2015)
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    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 172 (2015), p. 333-346
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 172 (2015), p. 333-346
    DDC: 610
    Abstract: Ethnobotanical survey was performed to document medicinal plants employed in the management of malaria in the Bosomtwe and Sekyere East Districts of the Ashanti Region (Ghana), in comparison with the plant ingredients in herbal antimalarial remedies registered by the Ghana Food and Drug Administration. Two hundred and three (203) herbalists from 33 communities within the two districts were interviewed on medicinal plants they use to manage malaria. A literature search was made to determine already documented plants. In addition, 23 finished marketed herbal products indicated for the management of malaria were identified and their labels examined to find out which of the plants mentioned in our survey were listed as ingredients and whether these products are in anyway regulated. Ninety-eight (98) species of plants were cited for the management of malaria. In comparison with literature citations, 12 (12.2%) species were reported for the management of malaria for the first time and 20 (20.4%) others for the first time in Ghana. Twenty-three (23) finished marketed herbal antimalarial products examined contained aerial or underground parts of 29 of the plants cited in our survey as ingredients. Twenty-two (22) of these products have been registered by the Ghana Food and Drugs Authority, four (4) of which were included in the recommended herbal medicine list for treating malaria in Ghana. This study provides new additions to the inventory of medicinal plants used for the management of malaria and reports the commercial availability and regulation of finished marketed labelled herbal products intended for the treatment of malaria in Ghana.
    Note: Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    DOI: 10.1016/j.jep.2015.06.041
    URL: Volltext
    URL: http://www.ncbi.nlm.nih.gov/pubmed/26151245
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    Article
    OLC Ethnologie
  • 2
    Article
    Article
    Clerodane diterpenes from Polyalthia longifolia (Sonn) Thw. var. pendula: Potential antimalarial agents for drug resistant Plasmodium falciparum infection (2015)
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    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 169 (2015), p. 176-182
    Details
    ISSN: 0378-8741
    Language: English
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 169 (2015), p. 176-182
    DDC: 610
    Abstract: Plasmodium falciparum drug resistance is a major public health challenge in sub-Sahara Africa. Many people are now resorting to the use of herbs in managing malaria due to the increasing treatment failures with the conventional drugs. In this study the ethanolic extract of Polyalthia longifolia (Sonn) Thw. var. pendula, a variety fondly used in folklore medicine in Ghana was investigated for potential antimalarial drug development. The ethanolic extract of P. longifolia (Sonn) Thw. var. pendula stem bark was screened against the multidrug resistant, K1 strain of P. falciparum by the parasite lactate dehydrogenase (pLDH) assay and a good antiplasmodial activity (IC50 22.04± 4.23µg/ml) was observed which led to further chromatographic analysis in search for actives. Bioassay guided fractionation of the extract yielded; three clerodane diterpenes [16-hydroxycleroda-3,13-dien-16,15-olide (1), 16-oxocleroda-3,13E-dien-15-oic acid (2) and 3,16-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide (3)], a steroid [beta-stigmasterol (4)] and two alkaloids [darienine (5) and stepholidine (6)]. While compounds 4, 5 and 6 exhibited weak antiplasmodial activity (IC50 22-105µg/ml), the clerodane diterpenes exhibited significantly potent (p〈0.005) blood schizonticidal activity (IC50: 3-6µg/ml). This is the first report of the antiplasmodial activity of compounds 2 and 3. In combination assay with chloroquine, compounds 1, 2, 3 and 5 antagonized the antiplasmodial activity of chloroquine while 4 and 6 demonstrated a synergistic action. The potent antiplasmodial activity of the extract of P. longifolia (Sonn) Thw. var. pendula and compounds therein strongly suggests its usefulness as an antimalarial agent and supports its inclusion or exploitation in formulations of herbal remedies for malaria in Ghana.
    Note: Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    DOI: 10.1016/j.jep.2015.04.014
    URL: Volltext
    URL: http://www.ncbi.nlm.nih.gov/pubmed/25914039
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    Article
    OLC Ethnologie
  • 3
    Article
    Article
    Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana (2008)
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    In:  Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs Vol. 119, No. 1 (2008), p. 141-144
    Details
    ISSN: 0378-8741
    Language: Undetermined
    Titel der Quelle: Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
    Publ. der Quelle: Shannon : Elsevier Science Ireland
    Angaben zur Quelle: Vol. 119, No. 1 (2008), p. 141-144
    DDC: 610
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    Article
    OLC Ethnologie
  • 4
    Article
    Article
    The role of the state in the age of globalisation (2006)
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    In:  The globalization reader (2006), Seite 240-243 | year:2006 | pages:240-243
    Details
    ISBN: 1405102802
    Language: Undetermined
    Titel der Quelle: The globalization reader
    Publ. der Quelle: Malden, Mass. [u.a.] : Blackwell, 2006
    Angaben zur Quelle: (2006), Seite 240-243
    Angaben zur Quelle: year:2006
    Angaben zur Quelle: pages:240-243
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    Article
    MPI Ethno. Forsch.
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